ZA856149B - 1-(aminophenyl)-2-aminopropanone derivatives - Google Patents
1-(aminophenyl)-2-aminopropanone derivativesInfo
- Publication number
- ZA856149B ZA856149B ZA856149A ZA856149A ZA856149B ZA 856149 B ZA856149 B ZA 856149B ZA 856149 A ZA856149 A ZA 856149A ZA 856149 A ZA856149 A ZA 856149A ZA 856149 B ZA856149 B ZA 856149B
- Authority
- ZA
- South Africa
- Prior art keywords
- piperazino
- alkyl
- groups
- halogen atom
- group
- Prior art date
Links
- -1 pyrrolidino, morpholino, thiomorpholino, piperidino, hexamethyleneimino, piperazino, 4-methylpiperazino Chemical group 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000003381 deacetylation reaction Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000012429 reaction media Substances 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8412962A FR2569184A1 (fr) | 1984-08-20 | 1984-08-20 | Derives de 1-(aminophenyl) therapeutique et leur procede de preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA856149B true ZA856149B (en) | 1986-04-30 |
Family
ID=9307106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA856149A ZA856149B (en) | 1984-08-20 | 1985-08-14 | 1-(aminophenyl)-2-aminopropanone derivatives |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4980377A (xx) |
| EP (1) | EP0174242B1 (xx) |
| JP (1) | JPS6183149A (xx) |
| AT (1) | ATE31915T1 (xx) |
| AU (1) | AU576886B2 (xx) |
| CA (1) | CA1240993A (xx) |
| DE (1) | DE3561391D1 (xx) |
| DK (1) | DK378685A (xx) |
| ES (1) | ES8604856A1 (xx) |
| FR (1) | FR2569184A1 (xx) |
| GR (1) | GR851997B (xx) |
| IE (1) | IE58214B1 (xx) |
| NZ (1) | NZ213097A (xx) |
| PT (1) | PT80991B (xx) |
| ZA (1) | ZA856149B (xx) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1250838A (fr) * | 1983-10-14 | 1989-03-07 | Louis Lafon | Procede de preparation de derives de 1-(acetylaminophenyl)-2-amino-propanone et les derives ainsi obtenus |
| US5236922A (en) * | 1984-08-20 | 1993-08-17 | Laboratoire L. Lafon | Method for treating depression using 1-(aminophenyl)-2-aminopropanone derivatives |
| FR2626878B1 (fr) * | 1988-02-10 | 1990-06-08 | Lafon Labor | Derives de 1-(aminophenyl)-2-dimethylaminopropanone, procede de preparation et utilisation en therapeutique |
| FR2626879B1 (fr) * | 1988-02-10 | 1990-06-08 | Lafon Labor | Derives de 1-(aminophenyl)-2-(n-2-hydroxyethylamino)-propanone, procede de preparation et utilisation en therapeutique |
| FR2626881B1 (fr) * | 1988-02-10 | 1990-07-27 | Lafon Labor | 1-(4-aminophenyl)-2-hexamethyleneiminopropanone, procede de preparation et utilisation en therapeutique |
| FR2653767B1 (fr) * | 1989-10-30 | 1992-02-14 | Lafon Labor | Derives de 1-(aminophenyl)-2-piperidinopropanone, procede et utilisation en therapeutique. |
| US5132457A (en) * | 1991-08-26 | 1992-07-21 | Mallinckrodt Specialty Chemicals Company | Stereospecific synthesis of 2(R)-2-methyl-3-dimethylamino-propiophenone (d-DAMP) |
| US5162566A (en) * | 1991-08-26 | 1992-11-10 | Mallinckrodt Specialty Chemicals Company | Stereospecific synthesis of tetrasubstituted acrylic esters |
| US6150420A (en) * | 1998-06-01 | 2000-11-21 | Theramax, Inc. | Method for enhanced brain delivery of bupropion |
| EP1896002A4 (en) | 2005-06-27 | 2009-11-25 | Biovail Lab Int Srl | BUPROPIONAL SALT FORMULATIONS WITH MODIFIED RELEASE |
| JP5711724B2 (ja) * | 2009-04-15 | 2015-05-07 | リサーチ・トライアングル・インスティチュート | モノアミン再取り込み阻害剤 |
| EP2571859B1 (en) | 2010-05-21 | 2015-07-22 | Research Triangle Institute | 1-phenylmorpholine derivatives as hydroxybupropion analogues for treating drug dependence |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA658735A (en) * | 1963-03-05 | Parke, Davis And Company | Isobutyrophenone compounds and their production by reaction of epoxy ethers with alkylamines | |
| US2128255A (en) * | 1934-12-22 | 1938-08-30 | Gen Aniline Works Inc | Azo dyestuffs |
| GB785988A (en) * | 1954-05-03 | 1957-11-06 | Du Pont | Basic monoazo dyes of the benzene-azo-benzene series |
| DE1618005A1 (de) * | 1966-09-22 | 1971-09-09 | Thomae Gmbh Dr K | Verfahren zur Herstellung von neuen Amino-dihalogen-phenyl-aethylaminen |
| DE1618007A1 (de) * | 1967-05-09 | 1970-10-29 | Thomae Gmbh Dr K | Verfahren zur Herstellung von neuen Amino-monohalogenphenylaethanolaminen |
| GB1262965A (en) * | 1969-03-21 | 1972-02-09 | Ferrosan As | Butyrophenones |
| BE759838A (fr) * | 1969-12-04 | 1971-06-03 | Wellcome Found | Cetones a activite biologique |
| US4119710A (en) * | 1972-12-18 | 1978-10-10 | Boehringer Ingelheim Gmbh | Bronchospasmolytic 1-(p-amino-phenyl)-2-amino-ethanols-(1) and salts |
| US4282206A (en) * | 1979-11-15 | 1981-08-04 | Westwood Pharmaceuticals Inc. | Method of protecting human skin from ultraviolet radiation |
| US4393078A (en) * | 1982-03-15 | 1983-07-12 | Burroughs Wellcome Co. | Bupropion and ethanol |
| CA1250838A (fr) * | 1983-10-14 | 1989-03-07 | Louis Lafon | Procede de preparation de derives de 1-(acetylaminophenyl)-2-amino-propanone et les derives ainsi obtenus |
| DE3565934D1 (en) * | 1984-07-25 | 1988-12-08 | Wellcome Found | Use of propiophenone compound |
| DE3508398A1 (de) * | 1985-03-08 | 1986-11-06 | Hoechst Ag, 6230 Frankfurt | Fungizide mittel auf der basis von 3-(hetero)-arylpropylaminen sowie neue (hetero)-aryl-propylamine und verfahren zu ihrer herstellung |
-
1984
- 1984-08-20 FR FR8412962A patent/FR2569184A1/fr not_active Withdrawn
-
1985
- 1985-08-09 EP EP85401624A patent/EP0174242B1/fr not_active Expired
- 1985-08-09 AT AT85401624T patent/ATE31915T1/de not_active IP Right Cessation
- 1985-08-09 DE DE8585401624T patent/DE3561391D1/de not_active Expired
- 1985-08-12 IE IE198485A patent/IE58214B1/en not_active IP Right Cessation
- 1985-08-14 ZA ZA856149A patent/ZA856149B/xx unknown
- 1985-08-14 ES ES546857A patent/ES8604856A1/es not_active Expired
- 1985-08-14 NZ NZ213097A patent/NZ213097A/en unknown
- 1985-08-15 CA CA000488750A patent/CA1240993A/en not_active Expired
- 1985-08-16 GR GR851997A patent/GR851997B/el unknown
- 1985-08-20 PT PT80991A patent/PT80991B/pt not_active IP Right Cessation
- 1985-08-20 JP JP60183768A patent/JPS6183149A/ja active Granted
- 1985-08-20 AU AU46465/85A patent/AU576886B2/en not_active Ceased
- 1985-08-20 DK DK378685A patent/DK378685A/da not_active Application Discontinuation
-
1988
- 1988-11-14 US US07/270,627 patent/US4980377A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IE58214B1 (en) | 1993-08-11 |
| IE851984L (en) | 1986-02-20 |
| DK378685A (da) | 1986-02-21 |
| PT80991B (pt) | 1987-09-30 |
| ES546857A0 (es) | 1986-03-01 |
| DE3561391D1 (en) | 1988-02-18 |
| US4980377A (en) | 1990-12-25 |
| EP0174242A2 (fr) | 1986-03-12 |
| CA1240993A (en) | 1988-08-23 |
| EP0174242B1 (fr) | 1988-01-13 |
| ES8604856A1 (es) | 1986-03-01 |
| GR851997B (xx) | 1985-12-17 |
| FR2569184A1 (fr) | 1986-02-21 |
| AU576886B2 (en) | 1988-09-08 |
| ATE31915T1 (de) | 1988-01-15 |
| JPH0560455B2 (xx) | 1993-09-02 |
| NZ213097A (en) | 1988-03-30 |
| EP0174242A3 (en) | 1986-03-26 |
| PT80991A (fr) | 1985-09-01 |
| AU4646585A (en) | 1986-02-27 |
| JPS6183149A (ja) | 1986-04-26 |
| DK378685D0 (da) | 1985-08-20 |
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