JPH0552195B2 - - Google Patents
Info
- Publication number
- JPH0552195B2 JPH0552195B2 JP60193867A JP19386785A JPH0552195B2 JP H0552195 B2 JPH0552195 B2 JP H0552195B2 JP 60193867 A JP60193867 A JP 60193867A JP 19386785 A JP19386785 A JP 19386785A JP H0552195 B2 JPH0552195 B2 JP H0552195B2
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- produced
- group
- microorganisms
- amino acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000008575 L-amino acids Chemical class 0.000 claims description 26
- 244000005700 microbiome Species 0.000 claims description 23
- 238000004519 manufacturing process Methods 0.000 claims description 16
- 108090000790 Enzymes Proteins 0.000 claims description 11
- 102000004190 Enzymes Human genes 0.000 claims description 11
- 230000000694 effects Effects 0.000 claims description 5
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- 125000001424 substituent group Chemical group 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 3
- OBSIQMZKFXFYLV-QMMMGPOBSA-N L-phenylalanine amide Chemical compound NC(=O)[C@@H](N)CC1=CC=CC=C1 OBSIQMZKFXFYLV-QMMMGPOBSA-N 0.000 claims description 2
- 238000006460 hydrolysis reaction Methods 0.000 claims description 2
- 241000588697 Enterobacter cloacae Species 0.000 claims 1
- JLSKPBDKNIXMBS-VIFPVBQESA-N L-tryptophanamide Chemical compound C1=CC=C2C(C[C@H](N)C(N)=O)=CNC2=C1 JLSKPBDKNIXMBS-VIFPVBQESA-N 0.000 claims 1
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- 238000006243 chemical reaction Methods 0.000 description 10
- 229940024606 amino acid Drugs 0.000 description 9
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
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- 150000001413 amino acids Chemical class 0.000 description 5
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- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
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- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 2
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- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
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- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 2
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
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- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 2
- 229960005190 phenylalanine Drugs 0.000 description 2
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- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- CLUOUYPICNCYNF-IPIKRLCPSA-N (2s)-2-amino-5-(diaminomethylideneamino)pentanoic acid;(2s)-2-amino-3-phenylpropanoic acid Chemical compound OC(=O)[C@@H](N)CCCNC(N)=N.OC(=O)[C@@H](N)CC1=CC=CC=C1 CLUOUYPICNCYNF-IPIKRLCPSA-N 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
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- 108010082340 Arginine deiminase Proteins 0.000 description 1
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- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
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- 239000012138 yeast extract Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60193867A JPS6255097A (ja) | 1985-09-04 | 1985-09-04 | Ｌ−アミノ酸の製造法 |
| GB8619969A GB2182036B (en) | 1985-09-04 | 1986-08-15 | Process for producing l-amino acids |
| DE3629242A DE3629242C2 (de) | 1985-09-04 | 1986-08-28 | Verfahren zur Herstellung von L-Aminosäuren |
| FR868612429A FR2586702B1 (fr) | 1985-09-04 | 1986-09-04 | Procede pour la production de l-amino-acides |
| US07/525,302 US5215897A (en) | 1985-09-04 | 1990-05-17 | Process for producing L-amino acids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60193867A JPS6255097A (ja) | 1985-09-04 | 1985-09-04 | Ｌ−アミノ酸の製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6255097A JPS6255097A (ja) | 1987-03-10 |
| JPH0552195B2 true JPH0552195B2 (xx) | 1993-08-04 |
Family
ID=16315072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60193867A Granted JPS6255097A (ja) | 1985-09-04 | 1985-09-04 | Ｌ−アミノ酸の製造法 |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS6255097A (xx) |
| DE (1) | DE3629242C2 (xx) |
| FR (1) | FR2586702B1 (xx) |
| GB (1) | GB2182036B (xx) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989001525A1 (en) * | 1987-08-17 | 1989-02-23 | Novo Industri A/S | Process for preparation of organic chemicals |
| US4981799A (en) * | 1987-08-21 | 1991-01-01 | Takeda Chemical Industries, Ltd. | Acylamino acid racemase, production and use thereof |
| US5252470A (en) * | 1988-03-24 | 1993-10-12 | Kyowa Hakko Kogyo Co., Ltd. | D-amidase and process for producing D-α-alanine and/or L-α-alanineamide |
| CA1336414C (en) * | 1988-03-24 | 1995-07-25 | Hideki Kawasaki | D-amidase and process for producing d--alanine and/or l--alanineamide |
| DE4014564C1 (xx) * | 1990-05-07 | 1991-07-18 | Forschungszentrum Juelich Gmbh, 5170 Juelich, De | |
| NL9100038A (nl) * | 1991-01-11 | 1992-08-03 | Stamicarbon | Enzym-gekatalyseerde bereiding van optisch aktieve carbonzuren. |
| JPH09506610A (ja) * | 1993-12-17 | 1997-06-30 | ディーエスエム エヌ．ブイ． | フェニルセリンアミド、及びフェニルセリン／フェニルセリンアミド の調製 |
| WO1995030740A1 (de) * | 1994-05-09 | 1995-11-16 | Degussa Aktiengesellschaft | Verfahren zur gewinnung von peptidamidase enthaltenden mikroorganismen, damit gewonnene mikroorganismen, darin enthaltene peptidamidasen und deren verwendung |
| GB9615852D0 (en) * | 1996-07-29 | 1996-09-11 | Allied Colloids Ltd | Production of amino acids and enzymes used therefor |
| WO2001087819A1 (en) * | 2000-05-18 | 2001-11-22 | Mitsubishi Rayon Co., Ltd. | PROCESS FOR PRODUCING OPTICALLY ACTIVE α-AMINO ACID AND OPTICALLY ACTIVE α-AMINO ACID AMIDE |
| JP4730913B2 (ja) * | 2007-07-31 | 2011-07-20 | 三菱レイヨン株式会社 | 光学活性ｔｅｒｔ−ロイシン及び光学活性ｔｅｒｔ−ロイシンアミドの製造方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5713000A (en) * | 1980-06-24 | 1982-01-22 | Ube Ind Ltd | Preparation of optical active tryptophane |
| JPS6036446A (ja) * | 1983-08-09 | 1985-02-25 | Mitsubishi Gas Chem Co Inc | Ｌ−α−アミノ酸の製造方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU74142A1 (xx) * | 1976-01-08 | 1977-07-22 | ||
| GB1577087A (en) * | 1977-01-07 | 1980-10-15 | Novo Industri As | Enzyme preparation having l-amino acyl amidase activity |
| DE3683512D1 (de) * | 1985-02-25 | 1992-03-05 | Mitsubishi Gas Chemical Co | Verfahren zur optischen isomerisierung von optisch aktiver aminosaeure und verfahren zur herstellung von optisch aktiver aminosaeure. |
-
1985
- 1985-09-04 JP JP60193867A patent/JPS6255097A/ja active Granted
-
1986
- 1986-08-15 GB GB8619969A patent/GB2182036B/en not_active Expired
- 1986-08-28 DE DE3629242A patent/DE3629242C2/de not_active Expired - Fee Related
- 1986-09-04 FR FR868612429A patent/FR2586702B1/fr not_active Expired
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5713000A (en) * | 1980-06-24 | 1982-01-22 | Ube Ind Ltd | Preparation of optical active tryptophane |
| JPS6036446A (ja) * | 1983-08-09 | 1985-02-25 | Mitsubishi Gas Chem Co Inc | Ｌ−α−アミノ酸の製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2586702B1 (fr) | 1989-12-15 |
| GB2182036B (en) | 1989-08-23 |
| FR2586702A1 (fr) | 1987-03-06 |
| DE3629242C2 (de) | 1993-12-02 |
| JPS6255097A (ja) | 1987-03-10 |
| GB2182036A (en) | 1987-05-07 |
| DE3629242A1 (de) | 1987-03-12 |
| GB8619969D0 (en) | 1986-09-24 |
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