JPH05501404A - ヌクレオシド誘導体 - Google Patents

ヌクレオシド誘導体

Info

Publication number
JPH05501404A
JPH05501404A JP2514754A JP51475490A JPH05501404A JP H05501404 A JPH05501404 A JP H05501404A JP 2514754 A JP2514754 A JP 2514754A JP 51475490 A JP51475490 A JP 51475490A JP H05501404 A JPH05501404 A JP H05501404A
Authority
JP
Japan
Prior art keywords
mmol
mixture
formula
tables
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2514754A
Other languages
English (en)
Japanese (ja)
Inventor
クラーヴエネス，ヨー
ウンネアイム，チエル
リーセ，フローデ
ハトレリド，ヨステアイン
Original Assignee
ニユコメド・アクシエセルカペト
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898925037A external-priority patent/GB8925037D0/en
Priority claimed from GB898925039A external-priority patent/GB8925039D0/en
Application filed by ニユコメド・アクシエセルカペト filed Critical ニユコメド・アクシエセルカペト
Publication of JPH05501404A publication Critical patent/JPH05501404A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP2514754A 1989-11-06 1990-11-06 ヌクレオシド誘導体 Pending JPH05501404A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB898925037A GB8925037D0 (en) 1989-11-06 1989-11-06 Nucleoside derivatives
GB898925039A GB8925039D0 (en) 1989-11-06 1989-11-06 Nucleoside derivatives
GB8925039.5 1989-11-06
GB8925037.7 1989-11-06

Publications (1)

Publication Number Publication Date
JPH05501404A true JPH05501404A (ja) 1993-03-18

Family

ID=26296164

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2514754A Pending JPH05501404A (ja) 1989-11-06 1990-11-06 ヌクレオシド誘導体

Country Status (7)

Country Link
EP (1) EP0500610A1 (de)
JP (1) JPH05501404A (de)
AU (1) AU636678B2 (de)
CA (1) CA2073063A1 (de)
FI (1) FI922014A (de)
OA (1) OA09697A (de)
WO (1) WO1991006554A1 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011099443A1 (ja) * 2010-02-15 2011-08-18 日産化学工業株式会社 β－ジヒドロフラン誘導化合物、β－ジヒドロフラン誘導化合物またはβ－テトラヒドロフラン誘導化合物の製造方法、β－グリコシド化合物、β－グリコシド化合物の製造方法、並びに、４'－エチニルｄ４Ｔ及びその類縁化合物の製造方法
US8975394B2 (en) 2010-02-15 2015-03-10 Nissan Chemical Industries, Ltd. Process for preparation of β-glycoside compounds

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
US5289904A (en) * 1992-08-28 1994-03-01 Harrison Everett W Sound dampener for disk brakes
JPH0692987A (ja) * 1992-09-17 1994-04-05 Tanabe Seiyaku Co Ltd ウリジン誘導体およびその製法
ATE169027T1 (de) * 1993-05-12 1998-08-15 Rhodia Limited Herstellung von fluoro-nukleosiden und dafür geeignete zwischenprodukte
GB9309795D0 (en) * 1993-05-12 1993-06-23 Rhone Poulenc Chemicals Preparation of flouro-compounds
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5703058A (en) 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US7635690B2 (en) 1999-01-22 2009-12-22 Emory University HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine
US7115584B2 (en) 1999-01-22 2006-10-03 Emory University HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine
US6132997A (en) 1999-05-28 2000-10-17 Agilent Technologies Method for linear mRNA amplification

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322747A (en) * 1965-04-01 1967-05-30 Merck & Co Inc Thionocarbonate nucleosides
US3817982A (en) * 1971-12-29 1974-06-18 Syntex Inc 2{40 ,3{40 -unsaturated nucleosides and method of making
CN1008443B (zh) * 1986-07-21 1990-06-20 大金工业株式会社 含聚四氟乙烯的涂层组合物及其用途
DD279407A1 (de) * 1986-07-24 1990-06-06 Akad Wissenschaften Ddr Verfahren zur herstellung eines mittels gegen aids
EP0286825A3 (de) * 1987-03-18 1989-04-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Verwendung von 3'-fluro-3'-deoxythymidine zur Herstellung von medicamenten zur Behandlung von Viruskrankheiten
AU613026B2 (en) * 1987-03-24 1991-07-25 Nycomed As 2',3' dideoxyribofuranoxide derivatives
GB8712115D0 (en) * 1987-05-22 1987-06-24 Hoffmann La Roche Pyrimidine derivatives
EP0294113A1 (de) * 1987-05-29 1988-12-07 The Wellcome Foundation Limited Therapeutische Nucleoside
ZA886890B (en) * 1987-10-09 1989-05-30 Hoffmann La Roche Novel dideoxycytidine derivatives
SE8704298D0 (sv) * 1987-11-03 1987-11-03 Astra Ab Compounds for use in therapy
GB8726136D0 (en) * 1987-11-07 1987-12-09 Wellcome Found Therapeutic nucleosides
ES2075040T3 (es) * 1988-02-16 1995-10-01 Lilly Co Eli 2',3'-dideoxi-2',2'-difluoronucleosidos.
EP0355031A3 (de) * 1988-08-17 1990-12-27 MATTHES, Eckart, Dr. Substituierte Pyrimidinnucleoside, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Mittel
GB8823320D0 (en) * 1988-10-05 1988-11-09 Nycomed As Chemical compounds
GB8823319D0 (en) * 1988-10-05 1988-11-09 Nycomed As Chemical compounds
JPH05505815A (ja) * 1990-04-04 1993-08-26 ニユコメド・イメージング・アクシエセルカペト ヌクレオシド誘導体

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011099443A1 (ja) * 2010-02-15 2011-08-18 日産化学工業株式会社 β－ジヒドロフラン誘導化合物、β－ジヒドロフラン誘導化合物またはβ－テトラヒドロフラン誘導化合物の製造方法、β－グリコシド化合物、β－グリコシド化合物の製造方法、並びに、４'－エチニルｄ４Ｔ及びその類縁化合物の製造方法
US8975394B2 (en) 2010-02-15 2015-03-10 Nissan Chemical Industries, Ltd. Process for preparation of β-glycoside compounds
US9212174B2 (en) 2010-02-15 2015-12-15 Nissan Chemical Industries, Ltd. Certain β-dihydrofuran derivatives
JP5924479B2 (ja) * 2010-02-15 2016-05-25 日産化学工業株式会社 β−ジヒドロフラン誘導化合物、β−ジヒドロフラン誘導化合物またはβ−テトラヒドロフラン誘導化合物の製造方法、並びにβ−グリコシド化合物の製造方法

Also Published As

Publication number Publication date
FI922014A0 (fi) 1992-05-05
FI922014A (fi) 1992-05-05
WO1991006554A1 (en) 1991-05-16
CA2073063A1 (en) 1991-05-07
AU6619290A (en) 1991-05-31
OA09697A (en) 1993-08-30
EP0500610A1 (de) 1992-09-02
AU636678B2 (en) 1993-05-06

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