AU636678B2 - Nucleoside derivatives - Google Patents

Nucleoside derivatives

Info

Publication number
AU636678B2
AU636678B2 AU66192/90A AU6619290A AU636678B2 AU 636678 B2 AU636678 B2 AU 636678B2 AU 66192/90 A AU66192/90 A AU 66192/90A AU 6619290 A AU6619290 A AU 6619290A AU 636678 B2 AU636678 B2 AU 636678B2
Authority
AU
Australia
Prior art keywords
mmol
added
dideoxy
pent
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU66192/90A
Other languages
English (en)
Other versions
AU6619290A (en
Inventor
Jostein Hatlelid
Jo Klaveness
Frode Rise
Kjell Undheim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Nycomed AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898925037A external-priority patent/GB8925037D0/en
Priority claimed from GB898925039A external-priority patent/GB8925039D0/en
Application filed by Nycomed AS filed Critical Nycomed AS
Publication of AU6619290A publication Critical patent/AU6619290A/en
Application granted granted Critical
Publication of AU636678B2 publication Critical patent/AU636678B2/en
Assigned to NYCOMED IMAGING AS reassignment NYCOMED IMAGING AS Amend patent request/document other than specification (104) Assignors: NYCOMED AS
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AU66192/90A 1989-11-06 1990-11-06 Nucleoside derivatives Ceased AU636678B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB898925037A GB8925037D0 (en) 1989-11-06 1989-11-06 Nucleoside derivatives
GB898925039A GB8925039D0 (en) 1989-11-06 1989-11-06 Nucleoside derivatives
GB8925037 1989-11-06
GB8925039 1989-11-06

Publications (2)

Publication Number Publication Date
AU6619290A AU6619290A (en) 1991-05-31
AU636678B2 true AU636678B2 (en) 1993-05-06

Family

ID=26296164

Family Applications (1)

Application Number Title Priority Date Filing Date
AU66192/90A Ceased AU636678B2 (en) 1989-11-06 1990-11-06 Nucleoside derivatives

Country Status (7)

Country Link
EP (1) EP0500610A1 (de)
JP (1) JPH05501404A (de)
AU (1) AU636678B2 (de)
CA (1) CA2073063A1 (de)
FI (1) FI922014A0 (de)
OA (1) OA09697A (de)
WO (1) WO1991006554A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) * 1909-10-07 2002-10-01 Medivir Ab Prodrugs
US5289904A (en) * 1992-08-28 1994-03-01 Harrison Everett W Sound dampener for disk brakes
JPH0692987A (ja) * 1992-09-17 1994-04-05 Tanabe Seiyaku Co Ltd ウリジン誘導体およびその製法
GB9309795D0 (en) * 1993-05-12 1993-06-23 Rhone Poulenc Chemicals Preparation of flouro-compounds
US5717086A (en) * 1993-05-12 1998-02-10 Rhone-Poulenc Chemicals Limited Preparation of fluoro-nucleosides and intermediates for use therein
US5703058A (en) 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US7635690B2 (en) 1999-01-22 2009-12-22 Emory University HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine
US7115584B2 (en) 1999-01-22 2006-10-03 Emory University HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine
US6132997A (en) * 1999-05-28 2000-10-17 Agilent Technologies Method for linear mRNA amplification
CN102741237B (zh) * 2010-02-15 2015-04-29 日产化学工业株式会社 β-二氢呋喃衍生化合物的制造方法
EP2537851B1 (de) 2010-02-15 2015-06-10 Nissan Chemical Industries, Ltd. Verfahren zur herstellung von b-glycosid-verbindungen

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0254269A2 (de) * 1986-07-21 1988-01-27 Daikin Industries, Limited Polytetrafluoräthylenhaltige Beschichtungsmasse und ihre Verwendung
EP0311100A2 (de) * 1987-10-09 1989-04-12 F. Hoffmann-La Roche Ag Neue Dideoxycytidin-Derivate, ihre Herstellung und Verwendung für Pharmazeutika
AU7558491A (en) * 1990-04-04 1991-10-30 Nycomed Imaging As Nucleoside derivatives

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322747A (en) * 1965-04-01 1967-05-30 Merck & Co Inc Thionocarbonate nucleosides
US3817982A (en) * 1971-12-29 1974-06-18 Syntex Inc 2{40 ,3{40 -unsaturated nucleosides and method of making
DD279407A1 (de) * 1986-07-24 1990-06-06 Akad Wissenschaften Ddr Verfahren zur herstellung eines mittels gegen aids
EP0286825A3 (de) * 1987-03-18 1989-04-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Verwendung von 3'-fluro-3'-deoxythymidine zur Herstellung von medicamenten zur Behandlung von Viruskrankheiten
ATE108183T1 (de) * 1987-03-24 1994-07-15 Nycomed Imaging As 2',3'-dideoxyribofuranoxid-derivate.
GB8712115D0 (en) * 1987-05-22 1987-06-24 Hoffmann La Roche Pyrimidine derivatives
EP0294113A1 (de) * 1987-05-29 1988-12-07 The Wellcome Foundation Limited Therapeutische Nucleoside
SE8704298D0 (sv) * 1987-11-03 1987-11-03 Astra Ab Compounds for use in therapy
GB8726136D0 (en) * 1987-11-07 1987-12-09 Wellcome Found Therapeutic nucleosides
ZA891076B (en) * 1988-02-16 1990-10-31 Lilly Co Eli 2',3'-dideoxy-2',2'-difluoronucleosides
EP0355031A3 (de) * 1988-08-17 1990-12-27 MATTHES, Eckart, Dr. Substituierte Pyrimidinnucleoside, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Mittel
GB8823320D0 (en) * 1988-10-05 1988-11-09 Nycomed As Chemical compounds
GB8823319D0 (en) * 1988-10-05 1988-11-09 Nycomed As Chemical compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0254269A2 (de) * 1986-07-21 1988-01-27 Daikin Industries, Limited Polytetrafluoräthylenhaltige Beschichtungsmasse und ihre Verwendung
EP0311100A2 (de) * 1987-10-09 1989-04-12 F. Hoffmann-La Roche Ag Neue Dideoxycytidin-Derivate, ihre Herstellung und Verwendung für Pharmazeutika
AU7558491A (en) * 1990-04-04 1991-10-30 Nycomed Imaging As Nucleoside derivatives

Also Published As

Publication number Publication date
OA09697A (en) 1993-08-30
CA2073063A1 (en) 1991-05-07
AU6619290A (en) 1991-05-31
FI922014A (fi) 1992-05-05
WO1991006554A1 (en) 1991-05-16
EP0500610A1 (de) 1992-09-02
FI922014A0 (fi) 1992-05-05
JPH05501404A (ja) 1993-03-18

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