JPH0543714B2 - - Google Patents
Info
- Publication number
- JPH0543714B2 JPH0543714B2 JP60244969A JP24496985A JPH0543714B2 JP H0543714 B2 JPH0543714 B2 JP H0543714B2 JP 60244969 A JP60244969 A JP 60244969A JP 24496985 A JP24496985 A JP 24496985A JP H0543714 B2 JPH0543714 B2 JP H0543714B2
- Authority
- JP
- Japan
- Prior art keywords
- coenzyme
- membrane
- separation membrane
- aqueous solution
- coenzymes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000012528 membrane Substances 0.000 claims description 75
- 239000005515 coenzyme Substances 0.000 claims description 69
- 238000000926 separation method Methods 0.000 claims description 36
- 239000007864 aqueous solution Substances 0.000 claims description 27
- 239000007795 chemical reaction product Substances 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 19
- 108090000790 Enzymes Proteins 0.000 claims description 18
- 102000004190 Enzymes Human genes 0.000 claims description 18
- 238000006911 enzymatic reaction Methods 0.000 claims description 15
- 239000000872 buffer Substances 0.000 claims description 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 10
- 125000000542 sulfonic acid group Chemical group 0.000 claims description 10
- 239000000243 solution Substances 0.000 claims description 9
- 239000011541 reaction mixture Substances 0.000 claims description 8
- 239000011780 sodium chloride Substances 0.000 claims description 5
- 239000007999 glycylglycine buffer Substances 0.000 claims description 4
- 239000007982 barbital buffer Substances 0.000 claims description 2
- 238000011084 recovery Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229920002492 poly(sulfone) Polymers 0.000 description 14
- 230000014759 maintenance of location Effects 0.000 description 11
- 229920000090 poly(aryl ether) Polymers 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 6
- 239000002131 composite material Substances 0.000 description 6
- 239000000758 substrate Substances 0.000 description 6
- 230000002378 acidificating effect Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000007853 buffer solution Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 150000002894 organic compounds Chemical class 0.000 description 4
- 230000000717 retained effect Effects 0.000 description 4
- 238000000108 ultra-filtration Methods 0.000 description 4
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000001506 calcium phosphate Substances 0.000 description 3
- 229910000389 calcium phosphate Inorganic materials 0.000 description 3
- 235000011010 calcium phosphates Nutrition 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 3
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 2
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000005194 fractionation Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical compound [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 description 2
- IIPYXGDZVMZOAP-UHFFFAOYSA-N lithium nitrate Chemical compound [Li+].[O-][N+]([O-])=O IIPYXGDZVMZOAP-UHFFFAOYSA-N 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000012466 permeate Substances 0.000 description 2
- 229920000098 polyolefin Polymers 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 108010006591 Apoenzymes Proteins 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- 108010008488 Glycylglycine Proteins 0.000 description 1
- 108010025076 Holoenzymes Proteins 0.000 description 1
- 208000029422 Hypernatremia Diseases 0.000 description 1
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 1
- 239000004962 Polyamide-imide Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004642 Polyimide Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- -1 alkylene glycol alkyl ether Chemical class 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 description 1
- 125000002843 carboxylic acid group Chemical group 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 239000012295 chemical reaction liquid Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229940043257 glycylglycine Drugs 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000003495 polar organic solvent Substances 0.000 description 1
- 229920001643 poly(ether ketone) Polymers 0.000 description 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
- 229920002312 polyamide-imide Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 238000001223 reverse osmosis Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 229920006159 sulfonated polyamide Polymers 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Saccharide Compounds (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24496985A JPS62106099A (ja) | 1985-10-30 | 1985-10-30 | 酵素反応における補酵素の分離回収方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24496985A JPS62106099A (ja) | 1985-10-30 | 1985-10-30 | 酵素反応における補酵素の分離回収方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62106099A JPS62106099A (ja) | 1987-05-16 |
| JPH0543714B2 true JPH0543714B2 (enrdf_load_stackoverflow) | 1993-07-02 |
Family
ID=17126643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP24496985A Granted JPS62106099A (ja) | 1985-10-30 | 1985-10-30 | 酵素反応における補酵素の分離回収方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS62106099A (enrdf_load_stackoverflow) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8075780B2 (en) * | 2003-11-24 | 2011-12-13 | Millipore Corporation | Purification and concentration of synthetic biological molecules |
| CN105481923B (zh) * | 2015-12-30 | 2018-07-31 | 平光制药股份有限公司 | 一种烟酰胺腺嘌呤二核苷酸的制备方法 |
-
1985
- 1985-10-30 JP JP24496985A patent/JPS62106099A/ja active Granted
Non-Patent Citations (1)
| Title |
|---|
| BIOTECHNOLOGY LETTERS=1985 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS62106099A (ja) | 1987-05-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4207182A (en) | Polymeric compositions for membranes | |
| US4376707A (en) | Process for the removal of urea from blood wash fluids and blood | |
| JP5203201B2 (ja) | 苛性アルカリ用途に有効な膜及び方法 | |
| IE41453B1 (en) | Process for separating citrate or citric acid in aqueous solutions | |
| CN1034991C (zh) | 磺化聚芳醚砜毫微滤膜的制备 | |
| US4613440A (en) | Composite membranes based on interpenetrating polymer networks | |
| Staude et al. | Polysulfones and their derivatives: materials for membranes for different separation operations | |
| JPS6365060B2 (enrdf_load_stackoverflow) | ||
| JPH0543714B2 (enrdf_load_stackoverflow) | ||
| CN114471197B (zh) | 一种混合荷电纳滤膜及其制备方法和应用 | |
| JPH0528109B2 (enrdf_load_stackoverflow) | ||
| NL9001273A (nl) | Semi-permeabel composietmembraan. | |
| CN1125635A (zh) | 一种改性聚砜超滤膜及其制备和应用 | |
| JPH0122009B2 (enrdf_load_stackoverflow) | ||
| CA1155112A (en) | Process for the purification of glucosaminoglucans | |
| CN113398784A (zh) | 新型纳滤膜的制备方法 | |
| JPH03133387A (ja) | マルトオリゴ糖の製造方法 | |
| JPS61209007A (ja) | 補酵素の選択的分離方法 | |
| JPH04200622A (ja) | 複合半透膜の処理方法 | |
| JPS5930123B2 (ja) | 半透膜用処理剤およびその製法 | |
| JPS62104588A (ja) | キシリト−ルの製造方法 | |
| JP2865381B2 (ja) | 水溶性染料の製造方法 | |
| SU1033510A1 (ru) | Способ получени пористых полимерных мембран | |
| JP3002577B2 (ja) | 複合逆浸透膜およびその製造方法 | |
| JPS62153298A (ja) | アルパルテ−ムの精製方法 |