JPH054368B2 - - Google Patents

Info

Publication number

JPH054368B2

JPH054368B2 JP24470590A JP24470590A JPH054368B2 JP H054368 B2 JPH054368 B2 JP H054368B2 JP 24470590 A JP24470590 A JP 24470590A JP 24470590 A JP24470590 A JP 24470590A JP H054368 B2 JPH054368 B2 JP H054368B2

Authority

JP

Japan

Prior art keywords

blood pressure

hydroxyvitamin

present

parts

vitamin

Prior art date

1983-08-02

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Lifetime

Links

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• OFHCOWSQAMBJIW-AVJTYSNKSA-N alfacalcidol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C OFHCOWSQAMBJIW-AVJTYSNKSA-N 0.000 claims description 7
• 239000008280 blood Substances 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 230000036772 blood pressure Effects 0.000 description 9
• GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical group C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 description 5
• 230000001105 regulatory effect Effects 0.000 description 4
• 239000007901 soft capsule Substances 0.000 description 4
• 239000000126 substance Substances 0.000 description 4
• -1 For example Chemical compound 0.000 description 3
• 239000002775 capsule Substances 0.000 description 3
• 239000000203 mixture Substances 0.000 description 3
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
• 229930003316 Vitamin D Natural products 0.000 description 2
• QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 2
• 230000004071 biological effect Effects 0.000 description 2
• 239000003795 chemical substances by application Substances 0.000 description 2
• 239000003240 coconut oil Substances 0.000 description 2
• 235000019864 coconut oil Nutrition 0.000 description 2
• 235000014113 dietary fatty acids Nutrition 0.000 description 2
• 239000002552 dosage form Substances 0.000 description 2
• 229930195729 fatty acid Natural products 0.000 description 2
• 239000000194 fatty acid Substances 0.000 description 2
• 150000004665 fatty acids Chemical class 0.000 description 2
• 238000009472 formulation Methods 0.000 description 2
• 239000000243 solution Substances 0.000 description 2
• 238000011699 spontaneously hypertensive rat Methods 0.000 description 2
• 239000011710 vitamin D Substances 0.000 description 2
• 235000019166 vitamin D Nutrition 0.000 description 2
• 150000003710 vitamin D derivatives Chemical class 0.000 description 2
• 229940046008 vitamin d Drugs 0.000 description 2
• BJYLYJCXYAMOFT-RRXOBRNQSA-N (1r,3s,5z)-5-[(2e)-2-[(1r,3as,7ar)-1-[(2r)-5-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCC(O)C(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C BJYLYJCXYAMOFT-RRXOBRNQSA-N 0.000 description 1
• 241000251468 Actinopterygii Species 0.000 description 1
• 206010061728 Bone lesion Diseases 0.000 description 1
• 206010006002 Bone pain Diseases 0.000 description 1
• 208000007530 Essential hypertension Diseases 0.000 description 1
• 108010010803 Gelatin Proteins 0.000 description 1
• 206010020772 Hypertension Diseases 0.000 description 1
• 208000013038 Hypocalcemia Diseases 0.000 description 1
• 208000000038 Hypoparathyroidism Diseases 0.000 description 1
• 241001465754 Metazoa Species 0.000 description 1
• 235000019483 Peanut oil Nutrition 0.000 description 1
• 241000700159 Rattus Species 0.000 description 1
• 208000003217 Tetany Diseases 0.000 description 1
• GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
• 201000006035 X-linked dominant hypophosphatemic rickets Diseases 0.000 description 1
• 230000002159 abnormal effect Effects 0.000 description 1
• 239000004480 active ingredient Substances 0.000 description 1
• 239000013543 active substance Substances 0.000 description 1
• 230000007059 acute toxicity Effects 0.000 description 1
• 231100000403 acute toxicity Toxicity 0.000 description 1
• 239000007864 aqueous solution Substances 0.000 description 1
• 239000007900 aqueous suspension Substances 0.000 description 1
• 230000004872 arterial blood pressure Effects 0.000 description 1
• WFZKUWGUJVKMHC-UKBUZQLGSA-N calcitetrol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CC[C@@H](O)C(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C WFZKUWGUJVKMHC-UKBUZQLGSA-N 0.000 description 1
• 239000011612 calcitriol Substances 0.000 description 1
• 208000020832 chronic kidney disease Diseases 0.000 description 1
• 208000022831 chronic renal failure syndrome Diseases 0.000 description 1
• 229940110456 cocoa butter Drugs 0.000 description 1
• 235000019868 cocoa butter Nutrition 0.000 description 1
• 239000007891 compressed tablet Substances 0.000 description 1
• 235000005687 corn oil Nutrition 0.000 description 1
• 239000002285 corn oil Substances 0.000 description 1
• 235000012343 cottonseed oil Nutrition 0.000 description 1
• 239000002385 cottonseed oil Substances 0.000 description 1
• 239000003814 drug Substances 0.000 description 1
• 229940079593 drug Drugs 0.000 description 1
• 150000002148 esters Chemical class 0.000 description 1
• 235000019441 ethanol Nutrition 0.000 description 1
• 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 1
• 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 1
• 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 1
• NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
• 235000019688 fish Nutrition 0.000 description 1
• 229920000159 gelatin Polymers 0.000 description 1
• 239000008273 gelatin Substances 0.000 description 1
• 235000019322 gelatine Nutrition 0.000 description 1
• 235000011852 gelatine desserts Nutrition 0.000 description 1
• 235000011187 glycerol Nutrition 0.000 description 1
• 239000007902 hard capsule Substances 0.000 description 1
• 238000010438 heat treatment Methods 0.000 description 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
• 230000000705 hypocalcaemia Effects 0.000 description 1
• 208000011111 hypophosphatemic rickets Diseases 0.000 description 1
• 210000004185 liver Anatomy 0.000 description 1
• 230000004060 metabolic process Effects 0.000 description 1
• 239000003921 oil Substances 0.000 description 1
• 235000019198 oils Nutrition 0.000 description 1
• 230000003287 optical effect Effects 0.000 description 1
• 208000005368 osteomalacia Diseases 0.000 description 1
• 239000000312 peanut oil Substances 0.000 description 1
• 239000008194 pharmaceutical composition Substances 0.000 description 1
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
• 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
• 229920000053 polysorbate 80 Polymers 0.000 description 1
• 229940068968 polysorbate 80 Drugs 0.000 description 1
• 239000003755 preservative agent Substances 0.000 description 1
• 230000002335 preservative effect Effects 0.000 description 1
• 239000007905 soft elastic gelatin capsule Substances 0.000 description 1
• 239000002904 solvent Substances 0.000 description 1
• 239000002511 suppository base Substances 0.000 description 1
• 208000024891 symptom Diseases 0.000 description 1
• 239000003826 tablet Substances 0.000 description 1
• BJYLYJCXYAMOFT-RSFVBTMBSA-N tacalcitol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CC[C@@H](O)C(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C BJYLYJCXYAMOFT-RSFVBTMBSA-N 0.000 description 1
• 235000010215 titanium dioxide Nutrition 0.000 description 1
• 150000003626 triacylglycerols Chemical class 0.000 description 1
• UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
• 208000032349 type 2B vitamin D-dependent rickets Diseases 0.000 description 1
• 235000015112 vegetable and seed oil Nutrition 0.000 description 1
• 239000008158 vegetable oil Substances 0.000 description 1
• 229930003231 vitamin Natural products 0.000 description 1
• 239000011782 vitamin Substances 0.000 description 1
• 229940088594 vitamin Drugs 0.000 description 1
• 235000013343 vitamin Nutrition 0.000 description 1
• 239000011647 vitamin D3 Substances 0.000 description 1
• QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
• 150000003722 vitamin derivatives Chemical class 0.000 description 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1