JPH0377173B2 - - Google Patents
Info
- Publication number
- JPH0377173B2 JPH0377173B2 JP17507183A JP17507183A JPH0377173B2 JP H0377173 B2 JPH0377173 B2 JP H0377173B2 JP 17507183 A JP17507183 A JP 17507183A JP 17507183 A JP17507183 A JP 17507183A JP H0377173 B2 JPH0377173 B2 JP H0377173B2
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- calcium
- hydroxyvitamin
- intestinal
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000011710 vitamin D Substances 0.000 claims description 12
- 229940046008 vitamin d Drugs 0.000 claims description 12
- 230000003167 anti-vitamin Effects 0.000 claims description 6
- 239000004480 active ingredient Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 150000003710 vitamin D derivatives Chemical class 0.000 description 10
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 9
- 229930003316 Vitamin D Natural products 0.000 description 9
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 9
- 239000011575 calcium Substances 0.000 description 9
- 229910052791 calcium Inorganic materials 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 235000019166 vitamin D Nutrition 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 230000000968 intestinal effect Effects 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- 102000005962 receptors Human genes 0.000 description 5
- 108020003175 receptors Proteins 0.000 description 5
- 241000700159 Rattus Species 0.000 description 4
- 239000002775 capsule Substances 0.000 description 3
- 210000000172 cytosol Anatomy 0.000 description 3
- GMRQFYUYWCNGIN-ZVUFCXRFSA-N 1,25-dihydroxy vitamin D3 Chemical compound C1([C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=CC=C1C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-ZVUFCXRFSA-N 0.000 description 2
- JWUBBDSIWDLEOM-NQZHSCJISA-N 25-hydroxy-3 epi cholecalciferol Chemical compound C1([C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=CC=C1C[C@H](O)CCC1=C JWUBBDSIWDLEOM-NQZHSCJISA-N 0.000 description 2
- 241000271566 Aves Species 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 208000022458 calcium metabolism disease Diseases 0.000 description 2
- 230000033444 hydroxylation Effects 0.000 description 2
- 238000005805 hydroxylation reaction Methods 0.000 description 2
- 230000009610 hypersensitivity Effects 0.000 description 2
- 208000030159 metabolic disease Diseases 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000007901 soft capsule Substances 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 1
- 208000037147 Hypercalcaemia Diseases 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- JWUBBDSIWDLEOM-DTOXIADCSA-N calcidiol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)CCC1=C JWUBBDSIWDLEOM-DTOXIADCSA-N 0.000 description 1
- 230000002308 calcification Effects 0.000 description 1
- 239000011612 calcitriol Substances 0.000 description 1
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 description 1
- 230000003913 calcium metabolism Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000000148 hypercalcaemia Effects 0.000 description 1
- 208000030915 hypercalcemia disease Diseases 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000001394 metastastic effect Effects 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 208000007442 rickets Diseases 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 239000011647 vitamin D3 Substances 0.000 description 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17507183A JPS6064924A (ja) | 1983-09-21 | 1983-09-21 | 抗ビタミンｄ剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17507183A JPS6064924A (ja) | 1983-09-21 | 1983-09-21 | 抗ビタミンｄ剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6064924A JPS6064924A (ja) | 1985-04-13 |
| JPH0377173B2 true JPH0377173B2 (enrdf_load_stackoverflow) | 1991-12-09 |
Family
ID=15989718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP17507183A Granted JPS6064924A (ja) | 1983-09-21 | 1983-09-21 | 抗ビタミンｄ剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6064924A (enrdf_load_stackoverflow) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180265463A1 (en) * | 2014-12-24 | 2018-09-20 | Kyoto University | Vitamin D3 Derivatives and Pharmaceutical Use Thereof |
| JP2023545918A (ja) | 2020-09-17 | 2023-11-01 | 学校法人帝京大学 | Ｓｒｅｂｐの阻害剤としてのｖｄｒサイレントビタミンｄ誘導体およびこの薬学的使用 |
-
1983
- 1983-09-21 JP JP17507183A patent/JPS6064924A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6064924A (ja) | 1985-04-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6375353B2 (ja) | ２５−ヒドロキシビタミンｄ３を含む経口剤形、及び、その経口剤形を週１回ヒトに投与することを含む方法 | |
| Dowdle et al. | Requirement for vitamin D for the active transport of calcium by the intestine | |
| US10046000B2 (en) | Use of 2-methylene-19-nor-(20S)-1α,25-Dihydroxyvitamin D3 to treat and prevent secondary hyperparathyroidism in a subject having renal failure | |
| Gallagher et al. | Effects of increasing doses of 1α‐hydroxyvitamin D2 on calcium homeostasis in postmenopausal osteopenic women | |
| JPH07501343A (ja) | 経口用１α−ヒドロキシプレビタミンＤ | |
| EA019837B1 (ru) | Применение 25-oh d3 для воздействия на физиологию мышц человека | |
| DE3013632A1 (de) | Mittel und seine verwendung zur regulierung des knochenmetabolismus | |
| JP3255926B2 (ja) | 腎機能障害患者における燐酸塩過剰血症予防のための１９−ノル−ビタミンｄ化合物の使用 | |
| US5053401A (en) | Osteogenesis promotion with use of vitamin d derivatives | |
| Brown et al. | Vitamin D analogs: new therapeutic agents for secondary hyperparathyroidism | |
| US20240130994A1 (en) | Ionic liquid formulations for treating diabetes | |
| JPH0780773B2 (ja) | 新規ビタミンｄ▲下３▼誘導体を有効成分とする医薬 | |
| JPH0377173B2 (enrdf_load_stackoverflow) | ||
| Boris et al. | In vivo studies in chicks and rats of bone calcium mobilization by 1α, 25-dihydroxycholecalciferol (calcitriol) and its congeners | |
| Halstead et al. | Comparison of 22-oxacalcitriol and 1, 25 (OH) 2D3 on bone metabolism in young X-linked hypophosphatemic male mice | |
| US10105375B2 (en) | Combination of low dose 2-methylene-19-nor-(20S)1α, 25-dihydroxyvitamin D3 and calcimimetics to treat secondary hyperparathyroidism | |
| JP3034897B2 (ja) | 副甲状腺機能亢進症治療剤 | |
| US4093746A (en) | Method of and fodder for rearing white-meat calves for slaughter | |
| Klahr et al. | Urinary phosphate and cyclic AMP in pseudohypoparathyroidism | |
| JPWO2005077378A1 (ja) | 家畜哺乳動物の低カルシウム血症の予防、治療および／または処置方法 | |
| Brown | Vitamin D analogs for the treatment of secondary hyperparathyroidism in chronic renal failure | |
| JPS61282317A (ja) | 骨代謝促進剤 | |
| HK1005015B (en) | Osteogenesis promotion with use of vitamin d derivatives | |
| JPS6064925A (ja) | 細胞分化誘導剤 | |
| JPH09201145A (ja) | 腎性骨異栄養症モデル動物 |