JPH03169817A - １α―ヒドロキシビタミンＤ↓３類を含有する血圧低下剤 - Google Patents
１α―ヒドロキシビタミンＤ↓３類を含有する血圧低下剤Info
- Publication number
- JPH03169817A JPH03169817A JP24470590A JP24470590A JPH03169817A JP H03169817 A JPH03169817 A JP H03169817A JP 24470590 A JP24470590 A JP 24470590A JP 24470590 A JP24470590 A JP 24470590A JP H03169817 A JPH03169817 A JP H03169817A
- Authority
- JP
- Japan
- Prior art keywords
- hydroxyvitamin
- 1alpha
- blood pressure
- pressure regulating
- regulating agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000036772 blood pressure Effects 0.000 title claims abstract description 12
- OFHCOWSQAMBJIW-AVJTYSNKSA-N alfacalcidol Chemical class C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C OFHCOWSQAMBJIW-AVJTYSNKSA-N 0.000 title claims abstract description 10
- 230000001105 regulatory effect Effects 0.000 title abstract description 6
- 239000000126 substance Substances 0.000 abstract description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 4
- 239000004480 active ingredient Substances 0.000 abstract description 3
- 239000003795 chemical substances by application Substances 0.000 abstract description 3
- 239000000203 mixture Substances 0.000 abstract description 3
- 239000000243 solution Substances 0.000 abstract description 3
- 239000007864 aqueous solution Substances 0.000 abstract description 2
- 239000007900 aqueous suspension Substances 0.000 abstract description 2
- 239000007891 compressed tablet Substances 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract description 2
- 235000019441 ethanol Nutrition 0.000 abstract description 2
- 239000007902 hard capsule Substances 0.000 abstract description 2
- 239000007905 soft elastic gelatin capsule Substances 0.000 abstract description 2
- 239000002511 suppository base Substances 0.000 abstract description 2
- 239000003826 tablet Substances 0.000 abstract description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 abstract description 2
- 244000299461 Theobroma cacao Species 0.000 abstract 1
- 235000005764 Theobroma cacao ssp. cacao Nutrition 0.000 abstract 1
- 235000005767 Theobroma cacao ssp. sphaerocarpum Nutrition 0.000 abstract 1
- 235000014121 butter Nutrition 0.000 abstract 1
- 235000001046 cacaotero Nutrition 0.000 abstract 1
- 210000000664 rectum Anatomy 0.000 abstract 1
- 239000007901 soft capsule Substances 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 229930003316 Vitamin D Natural products 0.000 description 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 239000003240 coconut oil Substances 0.000 description 2
- 235000019864 coconut oil Nutrition 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 150000003626 triacylglycerols Chemical class 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 235000019166 vitamin D Nutrition 0.000 description 2
- 239000011710 vitamin D Substances 0.000 description 2
- 150000003710 vitamin D derivatives Chemical class 0.000 description 2
- 229940046008 vitamin d Drugs 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 1
- 206010061728 Bone lesion Diseases 0.000 description 1
- 206010006002 Bone pain Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 208000013038 Hypocalcemia Diseases 0.000 description 1
- 208000000038 Hypoparathyroidism Diseases 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 208000015225 Primary intrahepatic lithiasis Diseases 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 208000003217 Tetany Diseases 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
- 201000006035 X-linked dominant hypophosphatemic rickets Diseases 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 230000004872 arterial blood pressure Effects 0.000 description 1
- 229960005084 calcitriol Drugs 0.000 description 1
- 208000020832 chronic kidney disease Diseases 0.000 description 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
- 235000019868 cocoa butter Nutrition 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000000705 hypocalcaemia Effects 0.000 description 1
- 208000011111 hypophosphatemic rickets Diseases 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000006371 metabolic abnormality Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 208000005368 osteomalacia Diseases 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 235000010215 titanium dioxide Nutrition 0.000 description 1
- 208000032349 type 2B vitamin D-dependent rickets Diseases 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24470590A JPH03169817A (ja) | 1983-08-02 | 1990-09-14 | １α―ヒドロキシビタミンＤ↓３類を含有する血圧低下剤 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14132383A JPS6045516A (ja) | 1983-08-02 | 1983-08-02 | １α―ヒドロキシビタミンＤ３類を含有することを特徴とする抗炎症解熱鎮痛剤 |
| JP24470590A JPH03169817A (ja) | 1983-08-02 | 1990-09-14 | １α―ヒドロキシビタミンＤ↓３類を含有する血圧低下剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14132383A Division JPS6045516A (ja) | 1983-08-02 | 1983-08-02 | １α―ヒドロキシビタミンＤ３類を含有することを特徴とする抗炎症解熱鎮痛剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH03169817A true JPH03169817A (ja) | 1991-07-23 |
| JPH054368B2 JPH054368B2 (enrdf_load_stackoverflow) | 1993-01-19 |
Family
ID=26473576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP24470590A Granted JPH03169817A (ja) | 1983-08-02 | 1990-09-14 | １α―ヒドロキシビタミンＤ↓３類を含有する血圧低下剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH03169817A (enrdf_load_stackoverflow) |
-
1990
- 1990-09-14 JP JP24470590A patent/JPH03169817A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPH054368B2 (enrdf_load_stackoverflow) | 1993-01-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1968567B1 (en) | Omega 3 fatty acid formulations | |
| US20130213851A1 (en) | Omega 3 fatty acid formulations | |
| HUE029572T2 (en) | Treatment of Vitamin D Insufficiency and Deficiency with 25-Hydroxy-D2 and 25-Hydroxy-D3 | |
| EP3047847A1 (en) | Methods and articles for treating 25-hydroxyvitamin d insufficiency and deficiency | |
| JPS5832823A (ja) | 脱癌剤 | |
| JPH0424325B2 (enrdf_load_stackoverflow) | ||
| CN103096877B (zh) | 维生素d的14‑差向异构‑类似物的新型制剂 | |
| JPH0319207B2 (enrdf_load_stackoverflow) | ||
| JPH03169817A (ja) | １α―ヒドロキシビタミンＤ↓３類を含有する血圧低下剤 | |
| JPH0780773B2 (ja) | 新規ビタミンｄ▲下３▼誘導体を有効成分とする医薬 | |
| JPS60120812A (ja) | 糖尿病性骨減少症治療剤 | |
| JPH03169820A (ja) | １α―ヒドロキシビタミンＤ↓３類を含有する血中脂質調節剤 | |
| JPH03169819A (ja) | １α―ヒドロキシビタミンＤ↓３類を含有する抗血栓症剤 | |
| JPH0319209B2 (enrdf_load_stackoverflow) | ||
| JPH03169818A (ja) | １α―ヒドロキシビタミンＤ↓３類を含有する抗血小板凝集剤 | |
| JP2876547B2 (ja) | 抗クル病剤 | |
| JPS58118516A (ja) | １α，２５−ジヒドロキシビタミンＤ↓３−２６，２３−ラクトンを含有するカルシユウム調節剤 | |
| RU2150269C1 (ru) | Мягкая капсула с лактобактериями для лечения дисбактериозов влагалища | |
| JPS6011422A (ja) | 抗筋ジストロフイ−症剤 | |
| JPS6221330B2 (enrdf_load_stackoverflow) | ||
| JPS6221333B2 (enrdf_load_stackoverflow) | ||
| JPS6011418A (ja) | 抗炎症剤 | |
| JPS6342606B2 (enrdf_load_stackoverflow) | ||
| JPS6011419A (ja) | 血圧降下剤 | |
| JPH0377173B2 (enrdf_load_stackoverflow) |