JPH052940B2 - - Google Patents
Info
- Publication number
- JPH052940B2 JPH052940B2 JP58079938A JP7993883A JPH052940B2 JP H052940 B2 JPH052940 B2 JP H052940B2 JP 58079938 A JP58079938 A JP 58079938A JP 7993883 A JP7993883 A JP 7993883A JP H052940 B2 JPH052940 B2 JP H052940B2
- Authority
- JP
- Japan
- Prior art keywords
- plasma
- isfet
- sensor
- film
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 18
- 239000000126 substance Substances 0.000 claims description 17
- 229920006254 polymer film Polymers 0.000 claims description 12
- 238000009832 plasma treatment Methods 0.000 claims description 11
- 125000000524 functional group Chemical group 0.000 claims description 9
- 229910021529 ammonia Inorganic materials 0.000 claims description 8
- 230000005669 field effect Effects 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 19
- 239000007789 gas Substances 0.000 description 13
- 229920000642 polymer Polymers 0.000 description 13
- 239000000427 antigen Substances 0.000 description 12
- 102000036639 antigens Human genes 0.000 description 12
- 108091007433 antigens Proteins 0.000 description 12
- 239000010408 film Substances 0.000 description 12
- 230000035945 sensitivity Effects 0.000 description 11
- 239000010409 thin film Substances 0.000 description 11
- 230000000052 comparative effect Effects 0.000 description 10
- 238000006116 polymerization reaction Methods 0.000 description 9
- 102000012406 Carcinoembryonic Antigen Human genes 0.000 description 7
- 108010022366 Carcinoembryonic Antigen Proteins 0.000 description 7
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- -1 antibodies Proteins 0.000 description 4
- 230000003100 immobilizing effect Effects 0.000 description 4
- 229920005597 polymer membrane Polymers 0.000 description 4
- 238000004544 sputter deposition Methods 0.000 description 4
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 3
- 108010088751 Albumins Proteins 0.000 description 3
- 102000009027 Albumins Human genes 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 102000008100 Human Serum Albumin Human genes 0.000 description 3
- 108091006905 Human Serum Albumin Proteins 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 230000002494 anti-cea effect Effects 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 102100026735 Coagulation factor VIII Human genes 0.000 description 2
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 2
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 2
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- 229910052581 Si3N4 Inorganic materials 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 229910052786 argon Inorganic materials 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000011261 inert gas Substances 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 229920000052 poly(p-xylylene) Polymers 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000010453 quartz Substances 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 description 2
- 229910052814 silicon oxide Inorganic materials 0.000 description 2
- XFOOPZIJVVDYHI-BQBZGAKWSA-N (2s)-2-amino-6-[[(2r)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-6-oxohexanoic acid Chemical compound OC(=O)[C@@H](N)CCCC(=O)N[C@@H](CS)C(=O)NCC(O)=O XFOOPZIJVVDYHI-BQBZGAKWSA-N 0.000 description 1
- WYTZZXDRDKSJID-UHFFFAOYSA-N (3-aminopropyl)triethoxysilane Chemical compound CCO[Si](OCC)(OCC)CCCN WYTZZXDRDKSJID-UHFFFAOYSA-N 0.000 description 1
- 102100023635 Alpha-fetoprotein Human genes 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 102000005701 Calcium-Binding Proteins Human genes 0.000 description 1
- 108010045403 Calcium-Binding Proteins Proteins 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 108010058846 Ovalbumin Proteins 0.000 description 1
- 108090000253 Thyrotropin Receptors Proteins 0.000 description 1
- 102100029337 Thyrotropin receptor Human genes 0.000 description 1
- 108010026331 alpha-Fetoproteins Proteins 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 210000003855 cell nucleus Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 230000005685 electric field effect Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- VLCAYQIMSMPEBW-UHFFFAOYSA-N methyl 3-hydroxy-2-methylidenebutanoate Chemical compound COC(=O)C(=C)C(C)O VLCAYQIMSMPEBW-UHFFFAOYSA-N 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 229910000069 nitrogen hydride Inorganic materials 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000001020 plasma etching Methods 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 239000003270 steroid hormone Substances 0.000 description 1
- 238000006557 surface reaction Methods 0.000 description 1
- 108091023025 thyroid hormone binding Proteins 0.000 description 1
- 102000028501 thyroid hormone-binding Human genes 0.000 description 1
- 238000001771 vacuum deposition Methods 0.000 description 1
- 238000007738 vacuum evaporation Methods 0.000 description 1
- 238000007740 vapor deposition Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/403—Cells and electrode assemblies
- G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
- G01N27/4145—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58079938A JPS59203951A (ja) | 1983-05-06 | 1983-05-06 | 生物電気化学センサ−の製造方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58079938A JPS59203951A (ja) | 1983-05-06 | 1983-05-06 | 生物電気化学センサ−の製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59203951A JPS59203951A (ja) | 1984-11-19 |
| JPH052940B2 true JPH052940B2 (de) | 1993-01-13 |
Family
ID=13704257
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58079938A Granted JPS59203951A (ja) | 1983-05-06 | 1983-05-06 | 生物電気化学センサ−の製造方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59203951A (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61176845A (ja) * | 1985-01-31 | 1986-08-08 | Nok Corp | 電界効果型トランジスター尿素センサー |
| JPS63171355A (ja) * | 1987-01-09 | 1988-07-15 | Seitai Kinou Riyou Kagakuhin Shinseizou Gijutsu Kenkyu Kumiai | 半導体化学センサ |
| JPH0713611B2 (ja) * | 1987-02-25 | 1995-02-15 | 帝人株式会社 | 免疫センサ及び免疫検出方法 |
| JPS6446639A (en) * | 1987-08-17 | 1989-02-21 | Nok Corp | Mutagen sensor |
| EP0315788B1 (de) * | 1987-10-13 | 1992-12-09 | Taiyo Yuden Co., Ltd. | Ionensensor |
| JP2004533238A (ja) * | 2001-04-14 | 2004-11-04 | コグニス・ドイッチュランド・ゲゼルシヤフト・ミト・ベシュレンクテル・ハフツング・ウント・コンパニー・コマンデイトゲゼルシヤフト | 化学的に不活性な表面上に生体分子を固定する方法 |
-
1983
- 1983-05-06 JP JP58079938A patent/JPS59203951A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS59203951A (ja) | 1984-11-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA1241695A (en) | Method of assay using a field effect transistor | |
| Bataillard et al. | Direct detection of immunospecies by capacitance measurements | |
| US4735906A (en) | Sensor having piezoelectric crystal for microgravimetric immunoassays | |
| RU2606852C2 (ru) | Способ детекции белков | |
| EP2291655B1 (de) | Sensor | |
| JPH03503567A (ja) | 酵素的に増幅された圧電特異的結合アツセイ | |
| JPS62231155A (ja) | 免疫センサ−用作用膜 | |
| EP0193154B1 (de) | Potentialverursachendes Element für einen Immunosensor | |
| Attili et al. | A piezoelectric immunosensor for the detection of cortisol | |
| JPH0543600A (ja) | 抗体または抗原固定化絹フイブロイン膜および免疫測定用センサー | |
| US20070039834A1 (en) | Method for detecting or asssaying target material, and electrode substrate, device, and kit used for the same | |
| JPH052940B2 (de) | ||
| CN114354722A (zh) | 多通道场效应晶体管纳米生物传感器及其制备方法、应用 | |
| CN101923092A (zh) | 丝网印刷电极的癌胚抗原工作电极的制备方法 | |
| Gotoh et al. | Micro-FET biosensors using polyvinylbutyral membrane | |
| JP2614905B2 (ja) | 免疫センサ | |
| CN111693589A (zh) | 生物传感器的制造方法、生物传感器及生物传感器的应用 | |
| RU2107296C1 (ru) | Способ электрохимической индикации иммунохимически активных макромолекул в исследуемых растворах | |
| CN111307912B (zh) | 一种场效应管生物传感器及其制备方法 | |
| An et al. | Dual‐Amplification of Antigen–Antibody Interactions via Backfilling Gold Nanoparticles on (3‐Mercaptopropyl) Trimethoxysilane Sol‐Gel Functionalized Interface | |
| WO1994023287A1 (en) | Immunoassay and immunoassay cell used therefor | |
| Bojorge-Ramírez et al. | Amperometric immunosensor for detecting Schistosoma mansoni antibody | |
| JPH0326345B2 (de) | ||
| Taniguchi et al. | A potentiometric immunoglobulin G sensor based on a polypyrrole modified platinum electrode | |
| JPS62288560A (ja) | バイオセンサ− |