JPH05194276A - エコー原粒子、それらの製造方法およびそれらの使用 - Google Patents

エコー原粒子、それらの製造方法およびそれらの使用

Info

Publication number
JPH05194276A
JPH05194276A JP4234020A JP23402092A JPH05194276A JP H05194276 A JPH05194276 A JP H05194276A JP 4234020 A JP4234020 A JP 4234020A JP 23402092 A JP23402092 A JP 23402092A JP H05194276 A JPH05194276 A JP H05194276A
Authority
JP
Japan
Prior art keywords
particles
acid
echogenic
particle
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
JP4234020A
Other languages
English (en)
Japanese (ja)
Inventor
Rainer Zotz
ライナー・ツオツツ
Volker Krone
フオルカー・クローネ
Axel Walch
アクセル・ヴアルヒ
Jurgen Grande
ユルゲン・グランデ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27202878&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPH05194276(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE4209488A external-priority patent/DE4209488A1/de
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of JPH05194276A publication Critical patent/JPH05194276A/ja
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Medicinal Preparation (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Glanulating (AREA)
JP4234020A 1991-09-03 1992-09-02 エコー原粒子、それらの製造方法およびそれらの使用 Abandoned JPH05194276A (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE4129187 1991-09-03
DE4209488A DE4209488A1 (de) 1992-03-24 1992-03-24 Echogene Partikel, Verfahren zu deren Herstellung und deren Verwendung
DE4209488:7 1992-03-24
DE4209487 1992-03-24
DE4209487:9 1992-03-24
DE4129187:5 1992-03-24

Publications (1)

Publication Number Publication Date
JPH05194276A true JPH05194276A (ja) 1993-08-03

Family

ID=27202878

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4234020A Abandoned JPH05194276A (ja) 1991-09-03 1992-09-02 エコー原粒子、それらの製造方法およびそれらの使用

Country Status (13)

Country Link
EP (1) EP0535387B2 (enExample)
JP (1) JPH05194276A (enExample)
KR (1) KR100267164B1 (enExample)
AT (1) ATE141518T1 (enExample)
AU (1) AU660039B2 (enExample)
CA (1) CA2077383A1 (enExample)
DE (1) DE59206943D1 (enExample)
DK (1) DK0535387T3 (enExample)
ES (1) ES2093160T5 (enExample)
GR (1) GR3021038T3 (enExample)
NO (1) NO305685B1 (enExample)
NZ (1) NZ244147A (enExample)
TW (1) TW222236B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008520648A (ja) * 2004-11-19 2008-06-19 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 分子的な撮像用の超音波造影剤

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
IN172208B (enExample) 1990-04-02 1993-05-01 Sint Sa
US7083778B2 (en) 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US6989141B2 (en) 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
DE4219723A1 (de) * 1992-06-13 1993-12-16 Schering Ag Mikropartikel, Verfahren zu deren Herstellung, sowie die Verwendung dieser in der Diagnostik
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
EP1550464A1 (en) 1993-07-30 2005-07-06 IMCOR Pharmaceutical Co. Stabilized microbubble composition for ultrasound
US6333021B1 (en) * 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
WO1996040277A2 (en) * 1995-06-07 1996-12-19 Brown University Research Foundation Spray dried polymeric microparticles containing imaging agents
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
IL126073A (en) * 1996-03-05 2002-02-10 Acusphere Inc Microencapsulated fluorinated gases for use as imaging agents
US5837221A (en) 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
EP1741968A1 (en) * 2005-07-08 2007-01-10 Uponor Innovation Ab Clamping ring

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4107288A (en) † 1974-09-18 1978-08-15 Pharmaceutical Society Of Victoria Injectable compositions, nanoparticles useful therein, and process of manufacturing same
US4265251A (en) * 1979-06-28 1981-05-05 Rasor Associates, Inc. Method of determining pressure within liquid containing vessel
US4718433A (en) † 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
US4900540A (en) † 1983-06-20 1990-02-13 Trustees Of The University Of Massachusetts Lipisomes containing gas for ultrasound detection
SE8701479L (sv) † 1987-04-09 1988-10-10 Carbomatrix Ab Metod foer inneslutning av biologiskt verksamma preparat samt anvaendning daerav
IE61591B1 (en) † 1987-12-29 1994-11-16 Molecular Biosystems Inc Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production
SE465910B (sv) * 1988-01-28 1991-11-18 Jan Axel Svensson Anordning foer sammankoppling av katetrar i en hudgenomgaang
JP2907911B2 (ja) * 1988-02-05 1999-06-21 シエーリング アクチエンゲゼルシヤフト 超音波造影剤、その製造方法及び該超音波造影剤からなる診断又は治療用製剤
US4957656A (en) † 1988-09-14 1990-09-18 Molecular Biosystems, Inc. Continuous sonication method for preparing protein encapsulated microbubbles
FR2660864A1 (fr) † 1990-04-13 1991-10-18 Guerbet Sa Composition de contraste, procede de preparation de cette composition et application a l'imagerie.
US5137928A (en) * 1990-04-26 1992-08-11 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
AU636481B2 (en) † 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US5236693A (en) * 1990-11-14 1993-08-17 Brigham And Women's Hospital Medical ultrasound contrast agent and method of using same
DE4219723A1 (de) † 1992-06-13 1993-12-16 Schering Ag Mikropartikel, Verfahren zu deren Herstellung, sowie die Verwendung dieser in der Diagnostik

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008520648A (ja) * 2004-11-19 2008-06-19 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 分子的な撮像用の超音波造影剤

Also Published As

Publication number Publication date
EP0535387A1 (de) 1993-04-07
NO923424D0 (no) 1992-09-02
GR3021038T3 (en) 1996-12-31
DK0535387T3 (da) 1996-12-09
DE59206943D1 (de) 1996-09-26
CA2077383A1 (en) 1993-03-04
AU2203992A (en) 1993-03-11
NO923424L (no) 1993-03-04
ES2093160T5 (es) 2002-03-16
NO305685B2 (no) 1999-07-12
NO305685B1 (no) 1999-07-12
NZ244147A (en) 1994-09-27
EP0535387B2 (de) 2001-10-04
ATE141518T1 (de) 1996-09-15
EP0535387B1 (de) 1996-08-21
ES2093160T3 (es) 1996-12-16
TW222236B (enExample) 1994-04-11
KR930005618A (ko) 1993-04-20
KR100267164B1 (ko) 2000-10-16
AU660039B2 (en) 1995-06-08

Similar Documents

Publication Publication Date Title
JP3381930B2 (ja) 超音波造影剤
JPH05194276A (ja) エコー原粒子、それらの製造方法およびそれらの使用
US5205287A (en) Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5190982A (en) Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5487390A (en) Gas-filled polymeric microbubbles for ultrasound imaging
CA2214778C (en) Process for the production of polymeric microparticles, microparticles that are produced according to this process as well as their use in medical diagnosis
US5562099A (en) Polymeric microparticles containing agents for imaging
TWI306869B (en) Amphiphilic block copolymers and nano particles comprising the same
KR100477857B1 (ko) 이미지형성제로사용되는마이크로캡슐화된불소첨가가스
KR100637022B1 (ko) 반사발생도를 증가시키고 미세캡슐화된 기체의 희석을감소시키는 방법
US5676925A (en) Contrast agents comprising gas-containing or gas-generating polymer microparticles or microballoons
US5613494A (en) Polycondensates which contain tartaric acid derivatives, processes for their preparation and use thereof
JP2001527547A (ja) 超音波コントラスト剤として、および、血流への薬剤デリバリーのために有用な微小パーティクル
EP0707474A1 (en) Medical use of organic aerogels and biodegradable organic aerogels
CA2196599A1 (en) Gas-filled microspheres with fluorine-containing shells
JP2005531648A (ja) 生体適合性物質およびプローブ類
JPH11509837A (ja) ガス充填アミノ酸ブロックコポリマーマイクロスフェア
CN101637613A (zh) 一种脂质靶向超声造影剂及其制备方法
DE4209488A1 (de) Echogene Partikel, Verfahren zu deren Herstellung und deren Verwendung
US20040022732A1 (en) Microparticles based on aspartic acid and use thereof as mri contrast agents
KR100752702B1 (ko) 생분해성 고분자 나노입자 및 그 제조방법
KR101927614B1 (ko) 초음파 영상을 위한 안정한 생체적합 산소-나노버블 조영제 제조방법
Kobauri et al. Amino Acid Based Biodegradable Amphiphilic Polymers and Micelles as Drug Delivery Systems: Synthesis and Study

Legal Events

Date Code Title Description
A762 Written abandonment of application

Free format text: JAPANESE INTERMEDIATE CODE: A762

Effective date: 20031216