JPH0516407B2 - - Google Patents

Info

Publication number

JPH0516407B2

JPH0516407B2 JP14033184A JP14033184A JPH0516407B2 JP H0516407 B2 JPH0516407 B2 JP H0516407B2 JP 14033184 A JP14033184 A JP 14033184A JP 14033184 A JP14033184 A JP 14033184A JP H0516407 B2 JPH0516407 B2 JP H0516407B2

Authority

JP

Japan

Prior art keywords

gallstones

cholelithiasis

present

coenzyme

therapeutic agent

Prior art date

1984-07-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Lifetime

Links

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• 201000001883 cholelithiasis Diseases 0.000 claims description 28
• 239000003814 drug Substances 0.000 claims description 11
• ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims description 10
• 229940124597 therapeutic agent Drugs 0.000 claims description 9
• 239000004480 active ingredient Substances 0.000 claims description 3
• 208000001130 gallstones Diseases 0.000 description 19
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 12
• 210000000232 gallbladder Anatomy 0.000 description 8
• 235000005911 diet Nutrition 0.000 description 7
• 230000037213 diet Effects 0.000 description 7
• XMGQYMWWDOXHJM-JTQLQIEISA-N (+)-α-limonene Chemical compound CC(=C)[C@@H]1CCC(C)=CC1 XMGQYMWWDOXHJM-JTQLQIEISA-N 0.000 description 6
• 235000012000 cholesterol Nutrition 0.000 description 6
• 230000000694 effects Effects 0.000 description 5
• 241000699670 Mus sp. Species 0.000 description 4
• 238000000034 method Methods 0.000 description 3
• 230000003381 solubilizing effect Effects 0.000 description 3
• RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 description 2
• BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
• 239000003613 bile acid Substances 0.000 description 2
• 230000015572 biosynthetic process Effects 0.000 description 2
• 150000001875 compounds Chemical class 0.000 description 2
• 229960002897 heparin Drugs 0.000 description 2
• 229920000669 heparin Polymers 0.000 description 2
• NRHMKIHPTBHXPF-TUJRSCDTSA-M sodium cholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 NRHMKIHPTBHXPF-TUJRSCDTSA-M 0.000 description 2
• 238000001356 surgical procedure Methods 0.000 description 2
• 208000024891 symptom Diseases 0.000 description 2
• 230000001225 therapeutic effect Effects 0.000 description 2
• HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 1
• 108091006149 Electron carriers Proteins 0.000 description 1
• 238000010171 animal model Methods 0.000 description 1
• 238000011888 autopsy Methods 0.000 description 1
• 210000000013 bile duct Anatomy 0.000 description 1
• RUDATBOHQWOJDD-BSWAIDMHSA-N chenodeoxycholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-BSWAIDMHSA-N 0.000 description 1
• 229960001091 chenodeoxycholic acid Drugs 0.000 description 1
• 239000005515 coenzyme Substances 0.000 description 1
• 238000004090 dissolution Methods 0.000 description 1
• 229940079593 drug Drugs 0.000 description 1
• 230000002183 duodenal effect Effects 0.000 description 1
• 235000006694 eating habits Nutrition 0.000 description 1
• 238000011156 evaluation Methods 0.000 description 1
• 238000002474 experimental method Methods 0.000 description 1
• 239000011521 glass Substances 0.000 description 1
• 230000002401 inhibitory effect Effects 0.000 description 1
• 210000004185 liver Anatomy 0.000 description 1
• 230000007774 longterm Effects 0.000 description 1
• 231100000053 low toxicity Toxicity 0.000 description 1
• 230000002980 postoperative effect Effects 0.000 description 1
• 230000000384 rearing effect Effects 0.000 description 1
• 238000006479 redox reaction Methods 0.000 description 1
• 238000012827 research and development Methods 0.000 description 1
• 239000000523 sample Substances 0.000 description 1
• 239000002904 solvent Substances 0.000 description 1
• 239000000126 substance Substances 0.000 description 1
• RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 description 1
• 229960001661 ursodiol Drugs 0.000 description 1