JPH0433767B2 - - Google Patents
Info
- Publication number
- JPH0433767B2 JPH0433767B2 JP57155628A JP15562882A JPH0433767B2 JP H0433767 B2 JPH0433767 B2 JP H0433767B2 JP 57155628 A JP57155628 A JP 57155628A JP 15562882 A JP15562882 A JP 15562882A JP H0433767 B2 JPH0433767 B2 JP H0433767B2
- Authority
- JP
- Japan
- Prior art keywords
- radioactive
- radioactive metal
- labeled
- physiologically active
- carrier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000002285 radioactive effect Effects 0.000 claims description 110
- 239000000203 mixture Substances 0.000 claims description 45
- 150000001875 compounds Chemical class 0.000 claims description 38
- 229910052751 metal Inorganic materials 0.000 claims description 31
- 239000002184 metal Substances 0.000 claims description 31
- 125000003277 amino group Chemical group 0.000 claims description 17
- 229940039227 diagnostic agent Drugs 0.000 claims description 17
- 239000000032 diagnostic agent Substances 0.000 claims description 17
- 238000002372 labelling Methods 0.000 claims description 13
- 239000003638 chemical reducing agent Substances 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 8
- 229910052713 technetium Inorganic materials 0.000 claims description 6
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 5
- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
- 239000013522 chelant Substances 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 150000003584 thiosemicarbazones Chemical class 0.000 claims description 4
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 229940088710 antibiotic agent Drugs 0.000 claims description 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 2
- 239000000194 fatty acid Substances 0.000 claims description 2
- 229930195729 fatty acid Natural products 0.000 claims description 2
- 150000004665 fatty acids Chemical class 0.000 claims description 2
- 229940088597 hormone Drugs 0.000 claims description 2
- 239000005556 hormone Substances 0.000 claims description 2
- 235000000346 sugar Nutrition 0.000 claims 1
- 150000008163 sugars Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 description 45
- 239000003795 chemical substances by application Substances 0.000 description 29
- 239000000243 solution Substances 0.000 description 25
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 description 24
- 229940056501 technetium 99m Drugs 0.000 description 24
- 102000008100 Human Serum Albumin Human genes 0.000 description 20
- 108091006905 Human Serum Albumin Proteins 0.000 description 20
- 239000007788 liquid Substances 0.000 description 16
- 238000004519 manufacturing process Methods 0.000 description 14
- 238000009206 nuclear medicine Methods 0.000 description 14
- GYHNNYVSQQEPJS-OIOBTWANSA-N Gallium-67 Chemical compound [67Ga] GYHNNYVSQQEPJS-OIOBTWANSA-N 0.000 description 12
- 229940006110 gallium-67 Drugs 0.000 description 12
- 238000003745 diagnosis Methods 0.000 description 11
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 10
- 238000001962 electrophoresis Methods 0.000 description 10
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 9
- -1 Schiff base compound Chemical class 0.000 description 9
- 238000006243 chemical reaction Methods 0.000 description 9
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 description 8
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 8
- 239000007864 aqueous solution Substances 0.000 description 8
- 229910021645 metal ion Inorganic materials 0.000 description 8
- 210000000056 organ Anatomy 0.000 description 8
- 229960005356 urokinase Drugs 0.000 description 8
- PNDPGZBMCMUPRI-HVTJNCQCSA-N 10043-66-0 Chemical compound [131I][131I] PNDPGZBMCMUPRI-HVTJNCQCSA-N 0.000 description 7
- 241001465754 Metazoa Species 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 230000005856 abnormality Effects 0.000 description 6
- 239000013543 active substance Substances 0.000 description 6
- 238000001727 in vivo Methods 0.000 description 6
- 230000000704 physical effect Effects 0.000 description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 5
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- APFVFJFRJDLVQX-AHCXROLUSA-N indium-111 Chemical compound [111In] APFVFJFRJDLVQX-AHCXROLUSA-N 0.000 description 5
- 229940055742 indium-111 Drugs 0.000 description 5
- 150000002739 metals Chemical class 0.000 description 5
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 4
- FTOAOBMCPZCFFF-UHFFFAOYSA-N 5,5-diethylbarbituric acid Chemical compound CCC1(CC)C(=O)NC(=O)NC1=O FTOAOBMCPZCFFF-UHFFFAOYSA-N 0.000 description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 241000700159 Rattus Species 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 150000001718 carbodiimides Chemical class 0.000 description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 4
- 238000000502 dialysis Methods 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
- 239000008351 acetate buffer Substances 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 239000012279 sodium borohydride Substances 0.000 description 3
- 229910000033 sodium borohydride Inorganic materials 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 238000004809 thin layer chromatography Methods 0.000 description 3
- IIYWMJZKABJHJV-UHFFFAOYSA-N 1-methyl-3-[[1-(methylcarbamothioylhydrazinylidene)-1-phenylpropan-2-ylidene]amino]thiourea Chemical compound CNC(=S)NN=C(C)C(=NNC(=S)NC)C1=CC=CC=C1 IIYWMJZKABJHJV-UHFFFAOYSA-N 0.000 description 2
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 2
- 208000031648 Body Weight Changes Diseases 0.000 description 2
- 102000008946 Fibrinogen Human genes 0.000 description 2
- 108010049003 Fibrinogen Proteins 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 229960005070 ascorbic acid Drugs 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- 229960002319 barbital Drugs 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000000975 bioactive effect Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 230000004579 body weight change Effects 0.000 description 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 2
- 229920002301 cellulose acetate Polymers 0.000 description 2
- 238000007385 chemical modification Methods 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000009849 deactivation Effects 0.000 description 2
- 238000004925 denaturation Methods 0.000 description 2
- 230000036425 denaturation Effects 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 229940012952 fibrinogen Drugs 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 230000004962 physiological condition Effects 0.000 description 2
- 230000001766 physiological effect Effects 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- ODLMAHJVESYWTB-UHFFFAOYSA-N propylbenzene Chemical compound CCCC1=CC=CC=C1 ODLMAHJVESYWTB-UHFFFAOYSA-N 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000007086 side reaction Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- QAEDZJGFFMLHHQ-UHFFFAOYSA-N trifluoroacetic anhydride Chemical compound FC(F)(F)C(=O)OC(=O)C(F)(F)F QAEDZJGFFMLHHQ-UHFFFAOYSA-N 0.000 description 2
- TXUICONDJPYNPY-UHFFFAOYSA-N (1,10,13-trimethyl-3-oxo-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl) heptanoate Chemical compound C1CC2CC(=O)C=C(C)C2(C)C2C1C1CCC(OC(=O)CCCCCC)C1(C)CC2 TXUICONDJPYNPY-UHFFFAOYSA-N 0.000 description 1
- WRMIJRQJYVDWRZ-UHFFFAOYSA-N (methylideneamino)thiourea Chemical compound NC(=S)NN=C WRMIJRQJYVDWRZ-UHFFFAOYSA-N 0.000 description 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical class C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 108010006654 Bleomycin Proteins 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- GYHNNYVSQQEPJS-YPZZEJLDSA-N Gallium-68 Chemical compound [68Ga] GYHNNYVSQQEPJS-YPZZEJLDSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- VEYYWZRYIYDQJM-ZETCQYMHSA-N N(2)-acetyl-L-lysine Chemical compound CC(=O)N[C@H](C([O-])=O)CCCC[NH3+] VEYYWZRYIYDQJM-ZETCQYMHSA-N 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- 239000002262 Schiff base Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 229910021626 Tin(II) chloride Inorganic materials 0.000 description 1
- ASVIKLJUPUSDHT-UHFFFAOYSA-N [[3-(aminomethylidene)-4-(carbamothioylhydrazinylidene)pentan-2-ylidene]amino]thiourea Chemical compound NC(=S)NN=C(C)C(=CN)C(C)=NNC(N)=S ASVIKLJUPUSDHT-UHFFFAOYSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 235000019445 benzyl alcohol Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229960001561 bleomycin Drugs 0.000 description 1
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- UPWPDUACHOATKO-UHFFFAOYSA-K gallium trichloride Chemical compound Cl[Ga](Cl)Cl UPWPDUACHOATKO-UHFFFAOYSA-K 0.000 description 1
- 230000005251 gamma ray Effects 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- DCPMPXBYPZGNDC-UHFFFAOYSA-N hydron;methanediimine;chloride Chemical compound Cl.N=C=N DCPMPXBYPZGNDC-UHFFFAOYSA-N 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- PSCMQHVBLHHWTO-UHFFFAOYSA-K indium(iii) chloride Chemical compound Cl[In](Cl)Cl PSCMQHVBLHHWTO-UHFFFAOYSA-K 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 239000007951 isotonicity adjuster Substances 0.000 description 1
- 229960000318 kanamycin Drugs 0.000 description 1
- 229930027917 kanamycin Natural products 0.000 description 1
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
- 229930182823 kanamycin A Natural products 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000009145 protein modification Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000001119 stannous chloride Substances 0.000 description 1
- 235000011150 stannous chloride Nutrition 0.000 description 1
- BKVIYDNLLOSFOA-OIOBTWANSA-N thallium-201 Chemical compound [201Tl] BKVIYDNLLOSFOA-OIOBTWANSA-N 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- 238000007738 vacuum evaporation Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
æ¬çºæã¯ãç¹å®èåšã®æåºãç¹å®çŸæ£ã®æ€åºã
ãã³çç掻æ§ååç©ã®åæ æ€æ»ãªã©ãç®çãšãã
æ žå»åŠççšéã«æçšãªãæ°ããå®å®ãªæŸå°æ§éå±
æšèã€ãæŸå°æ§èšºæå€ã«é¢ãããã®ã§ãããããª
ãã¡ãæ¬çºæã¯ã ååŠåŒ ïŒåŒäžïŒ²ã¯ççŽ æ°ïŒãïŒã®ã¢ã«ãã«åºãããªã
矀ããéžã°ããåºãè¡šãããïœã¯ïŒãïŒ ã®æŽæ°
ãè¡šãããïŒ ã§ç€ºãããããªã»ãã«ã«ããŸã³èªå°äœïŒä»¥äžãã
ããç·ç§°ããŠãã¢ããPTSãšç¥ç§°ããïŒããç¹
å®èåšããã³ç¹å®çŸæ£éšäœãžã®å±åšæ§ãæããç
ç掻æ§ååç©ãšçµåãããŠåœ¢æããããšãããªã
ååç©ïŒä»¥äžéæŸå°æ§ãã€ãªã€ãšç¥ãïŒãå«ãã
ãšãç¹åŸŽãšããéæŸå°æ§çµæç©ã«é¢ãããã®ã§ã
ãããŸãä»ã®ç¹ããã¯ãã¢ããPTSã該çç掻
æ§ååç©ãçµåãããŠåœ¢æããããšãããªãéæŸ
å°æ§ãã€ãªã€ãå«ãããšãç¹åŸŽãšããéæŸå°æ§çµ
æç©ããæŸå°æ§éå±ã€ãªã³ãå«æãã溶液ãšæ¥è§Š
ãããŠåœ¢æããããšãããªãæŸå°æ§éå±æšèã€ã
å®å®ãªæŸå°æ§èšºæå€ã«é¢ãããã®ã§ããã ç¹å®èåšã®æåºãç¹å®çŸæ£ã®æ€åºããã³åæ æ€
æ»ãªã©ãç®çãšããé䟵襲çæ žå»åŠèšºæã®ãã
ã«ãåŸæ¥ããšãŒããŒ131ã§æšèãããçç掻æ§å
åç©ãæ±çšãããŠæ¥ããäŸãã°ãè¡æ¶²åŸªç°ç³»ã®æ
åºããã³åæ æ€æ»ã«çšãããããšãŒããŒ131æšè
人è¡æž ã¢ã«ããã³ãè¡æ ã®æ€åºãç®çãšãããšãŒ
ããŒ131æšèãã€ããªããŒã²ã³ãªã©ãæããããã
ããããªããããšãŒããŒ131ã¯ãåæžæãçŽïŒæ¥
ãšé·ãããã€ãæ žå»åŠèšºæã«æçšãªã¬ã³ãç·ã®ä»
ã«ãããŒã¿ç·ãæŸåºããããã被éšè ã«å€éã®æŸ
å°ç·è¢«æãäžããæ¬ ç¹ãããããšãææãããŠã
ãã æ žå»åŠèšºæã«ããæµããç©ççç¹æ§ãæããæŸ
å°æ§éå±ãä»ã®æ¹æ³ã«ããçç掻æ§ååç©ã«å°å ¥
ããæçšãªæŸå°æ§èšºæå€ãåŸãããšããè©Šã¿ãç¶
ããããŠãããããªãã¡ããã¬ãŒãçµåã®åœ¢æã
æåŸ ããŠãçç掻æ§ååç©ã«çŽæ¥ãæŸå°æ§éå±å¡©
ãäœçšãããŠãããªãæšèæ³ã§ãããäŸãã°ã人
è¡æž ã¢ã«ããã³ã«é©åœãªéå å€ã®ååšäžã«ãéã
ã¯ãããŠã é žå¡©ã®åœ¢ã§ãã¯ãããŠã â99mãå«ã
氎溶液ãäœçšãããŠããã¯ãããŠã â99mæšè人
è¡æž ã¢ã«ããã³ãåŸãæ¹æ³ããã¬ãªãã€ã·ã³ã«ã
å¡©åã€ã³ãžãŠã ã®åœ¢ã§ã€ã³ãžãŠã â111ãå«ãæ°Ž
溶液ãäœçšãããŠãã€ã³ãžãŠã â111æšèãã¬ãª
ãã³ã·ã³ãåŸãæ¹æ³ãªã©ãããã«ããããããã
ãªãããããããæšèãããã¹ãçç掻æ§ååç©
ã®ãã¬ãŒã圢ææ§ã¯ãå¿ ããã倧ãããªããåèš
ã®ãã¯ãããŠã â99mæšè人è¡æž ã¢ã«ããã³ãã€
ã³ãžãŠã â111æšèãã¬ãªãã³ã·ã³ã®å Žåã«ãã
ãŠããäœå æäžåŸã®å®å®æ§ãäœããæŸå°èœã®äœå
æåããçç掻æ§ååç©ã®æåãšäžèŽãããæ žå»
åŠèšºæãç®çãšããçšéã«ãããŠãæºè¶³ãã¹ãã
ã®ã§ã¯ãªãããšãææãããŠããã ããã§èšãçç掻æ§ååç©ãšã¯ãç¹å®èåšãŸã
ã¯ç¹å®æ£éšäœã«ç¹ç°ãªéç©æ§ã瀺ãããŸãã¯ãç
äœå ã«ãããçççãªè«žç¶æ ã«å¯Ÿå¿ããç¹ç°ãªå
æ ããšããããªååç©ãæããã®ã§ããããã®äœ
å æåã远跡ããããšã«ãããåçš®ã®èšºæã«æçš
ãªæ å ±ãæäŸããããšãæåŸ ããããããªååç©
ã§ããããã®ãããªçç掻æ§ååç©ã«ãåªããç©
ççç¹æ§ãæããæŸå°æ§éå±ãå®å®ã«ããããã
該ååç©ã®çç掻æ§ããããªãããšãªãå°å ¥ãã
ããšãã§ããã°ãæ žå»åŠèšºæã«ãããŠã極ããŠæ
çšãªãããšãæåŸ ãããæ žå»åŠçã«ãããŠãã®ã
ããªæŸå°æ§èšºæå€ã®åºçŸã匷ãèŠæãããŠãããš
ããã§ããã æ¬çºæè ãã¯ãå ã«ãåæ§ã®åºæ¬çæ§æ³ã§ç 究
ãé²ããçµæãïŒâãªããœããã©âã«ãã¹ïŒïŒ®â
ã¡ãã«ããªã»ãã«ã«ããŸã³ïŒã«ã«ãã³é žãèŠãåº
ããïŒç¹æé56â34664ïŒãããããªããããã®å
åç©ã®çç掻æ§ç©è³ªã«å¯Ÿããåå¿æªç«¯ã¯ãã«ã«ã
ã³é žã§ãããæ¬çºæã®ã¢ããPTSïŒåå¿æªç«¯ã¢ã
ãåºïŒãšã¯ãçç掻æ§ç©è³ªãšã®çµåã®ããã®åå¿
æ¹æ³ãªã©ããã®ããšç°ãªããã®ã§ããããŸããäž
ç°ãã¯ãæ¬çºæè ããšåãåºæ¬çèãæ¹ã«ããç
究ãé²ããïŒâã¢ããã¡ãã¬ã³â2.4âãã³ã¿ã³
ãžãªã³âãã¹ïŒããªã»ãã«ã«ããŸã³ïŒããã³ãã®
èªå°äœãæçšã§ãããšããŠããïŒç¹éæ57â
102860ïŒãããã®æ§é åŒããå€æããŠã(1)ãã¬ãŒ
ã圢æåºãšãçç掻æ§ç©è³ªã«å¯Ÿããåå¿æ«ç«¯ïŒã¢
ããåºïŒãããŸãã«ã¯æ¥è¿ããŠããããšã(2)åå¿
æ«ç«¯ã§ããã¢ããåºããäºéçµåãæããççŽ ã«
çµåããŠãããããã¢ããåºçªçŽ äžã®é»åå¯åºŠã
äœãããšãçã«ãããçç掻æ§ç©è³ªãšã®åå¿æ§ã«
åé¡ç¹ããªãããšäºæ³ãããã æ¬çºæã®ç®çã¯ãåèšã®èŠæã«å¿ããŠãåçš®ã®
çç掻æ§ååç©ã®ãåªããç©ççæ§è³ªãæã€æŸå°
æ§éå±æšèååç©ã§ãããããªããã€ãå®å®ã§ã
ããæŽã«ã¯ããã容æãªææ³ã«ãã€ãŠåŸãããã
ããªãæŽã«ã¯ã該çç掻æ§ååç©ã®æŽ»æ§ãä¿æã
ãæšèååç©ã§ãããããªæŸå°æ§èšºæå€ãæäŸã
ãããšã«ããã æ¬çºæè ãã¯ãã¢ããPTSã®åŒ·ããã¬ãŒã圢
æèœåãšãçç掻æ§ååç©ã®ã¢ããåºãããã¯ã«
ã«ããã·åºãšç©åãªæ¡ä»¶äžã§çµåããèœåãæã
ãã¢ããåºããã€ãšããç¹ã«çç®ããå®éšæ€èšã
å ããçµæãéåžžã«åªããéæŸå°æ§çµæç©ããã³
æŸå°æ§èšºæå€ã補é ããåŸããšãçºèŠããã ããªãã¡ãã¢ããPTSãã氎溶æ§ã«ã«ããžã€
ããã®ååšäžã«ã«ã«ããã·ã«åºãæããçç掻æ§
ååç©ãšæ¥è§Šããããšãã極ããŠç©åãªæ¹æ³ã«ã
ã€ãŠçç掻æ§ååç©ã®å€æ§ããã³å€±æŽ»ããšããªã
ããšãªããã¢ããPTSã®æ«ç«¯ã¢ããåºãä»ããŠ
çç掻æ§ååç©ãšã®éã«ååŠçµåã圢æãããã
éåžžã«åŒ·ããã¬ãŒã圢æèœãæã€ãéæŸå°æ§ãã€
ãªã€ã補é ãããããšãèŠãåºããããŸããã¢ã
ãPTSãã¢ããåºãæããŠãããšããå©ç¹ãç
ãããŠãã¢ããåºãæããçç掻æ§ååç©ã«å¯Ÿã
ãŠããã¿ã³ãã¯ã®ååŠä¿®é£Ÿæ³ãšããŠéåžžçšããã
ãã°ã«ã¿ã«ã¢ã«ãããæ³ã«ãããã°ã«ã¿ã«ã¢ã«ã
ãããã¢ããPTSãšã¢ããåºãæããçç掻æ§
ååç©ãšã®æ¶æ©ç©è³ªãšããŠãã·ããå¡©åºã圢æã
ããããã«æ°ŽçŽ åããŠçŽ ãããªãŠã çã®éå å€ã
äœçšãããããšã«ãã€ãŠæ¥µããŠå®å®ãªéæŸå°æ§ã
ã€ãªã¢ã補é ãåŸãããšãèŠãåºãããã€ãã§ã
ãããã®éæŸå°æ§ãã€ãªã¢ãå«ãéæŸå°çµæç©ã«
æŸå°æ§éå±ã€ãªã³ãå«ã氎溶液ãæ¥è§Šããããšã
ã極ããŠç°¡äŸ¿ãªæ¹æ³ã«ãã€ãŠãæŸå°æ§éå±æšèã€
ãçç掻æ§ååç©ã§ãããããªæŸå°æ§èšºæå€ã補
é ãåŸãããšãèŠãåºããã ãªããæ žå»åŠèšºæã«ãããŠæ±çšãããéãã¯ã
ããŠã é žå¡©ã®åœ¢ã§åžè²©ãããŠãããã¯ãããŠã â
99mãªã©ã®æŸå°æ§éå±ã€ãªã³ã®ããã«ããã®ãŸãŸ
ã®åå䟡ç¶æ ã§ã¯åèšã®éæŸå°æ§ãã€ãªã€ãšåŒ·åº
ã«çµåããªãå Žåããã®ãããªæŸå°æ§éå±ã€ãªã³
ãã匷åºãªçµåã®åœ¢æã«æå©ãªäœåå䟡ç¶æ ã«é
å ããããã«ã第äžã¹ãºå¡©çã®éå å€ããã®ãŸãŸ
ã®åœ¢ã§ããŸãã¯ã€ãªã³äº€ææš¹èã«åžçããã圢ã§
ãããããéæŸå°æ§çµæç©äžã«å«æãããŠãã
ã°ãåè¿°ãšåæ§ã®ç°¡äŸ¿ãªæ¹æ³ã«ããæŸå°æ§éå±æš
èã€ãæŸå°æ§èšºæå€ã補é ãåŸãã æ¬çºæã®æ¹æ³ã«ãã補é ãããéæŸå°æ§çµæç©
ããã³æŸå°æ§èšºæå€ã¯ãç¹å®èåšã®æåºãç¹å®çŸ
æ£ã®æ€åºããã³åæ æ€æ»ãç®çãšããæ žå»åŠççš
éã«æ¥µããŠæçšãªå©ç¹ãæããã ãŸãéæŸå°æ§ãã€ãªã€ããã³éæŸå°æ§ãã€ãªã€
ãå«ãéæŸå°æ§çµæç©ã®ç¹é·ã«ã€ããŠè¿°ã¹ããšä»¥
äžã®ããšãã§ããã (a) 補é åŸãå åãªæéãå®å®ã§ããã (b) ã¢ããPTSãæ«ç«¯ã¢ããåºãæããããã
äžè¬ã«ã¿ã³ãã¯ã®ååŠä¿®é£Ÿæ³ã«çšãããã極ã
ãŠç·©åãªæ¹æ³ã«ãã補é ãåŸãã®ã§ãçç掻æ§
ååç©ã®å€±æŽ»ãå€æ§ãå解ãªã©å¥œãŸãããªãå¯
åå¿ããšããªããªãã (c) çç掻æ§ååç©ã®ååäžã«ãã¢ããåºãŸãã¯
ã¢ã«ããã·ã«åºã®ãããããæããŠããã°ã容
æã«ç®çãšããéæŸå°æ§ãã€ãªã€ã補é ãåŸ
ãã (d) ã¢ããåºãã«ã«ããã·ã«åºãæããªãçç掻
æ§ååç©ã®å Žåã«ã¯ãé©åœãªæ¹æ³ã«ããã¢ãã
åºãŸãã¯ã«ã«ããã·ã«åºãå°å ¥ããçç掻æ§å
åç©èªå°äœãåé§äœãšããŠçšæããããšã«ã
ããåæ§ã«éæŸå°æ§ãã€ãªã€ã補é ãåŸãã (e) æŸå°æ§éå±ã€ãªã³ãå«ã氎溶液ãæ¥è§Šããã
ãšããæäœã ãã§æ¥µããŠç°¡äŸ¿ã«æŸå°æ§éå±æšè
ã€ãæŸå°æ§èšºæå€ã調補ããããšãã§ããã 次ã«ãæŸå°æ§éå±æšèã€ãæŸå°æ§èšºæå€ã«ã€ã
ãŠã®ç¹é·ããããã°ã以äžã®ããšãã§ããã (a) 補é åŸãå åãªæéãå®å®ã§ããã (b) æŸå°æ§éå±ã«ããæšèçã¯ã»ãŒ100ïŒ ã§ãã
極ããŠé«ãã (c) æšèæäœã«ãããçç掻æ§ååç©ã®å€±æŽ»ãå€
æ§ãå解ãªã©ã®å¥œãŸãããªãå¯åå¿ã¯ãšããªã
ãªãã (d) åæžæãæŸåºã¬ã³ãç·ãšãã«ã®ãŒãªã©ã®ç©ç
çç¹æ§ã®é¢ã§æ žå»åŠèšºæã«æµããçš®ã ã®æŸå°æ§
éå±ã®ãã¡ãããç®çãšããæ žå»åŠç蚺æã«æ
ãæµããæŸå°æ§éå±ãéžã¶ããšãã§ããããã
ã€ãŠãæ žå»åŠèšºæã«ãããæ å ±éã粟床ãåäž
ããããã€æ£è ã®è¢«æç·éã軜æžããããšãã§
ããã æ¬çºæã«ããããçç掻æ§ååç©ã«ã€ããŠäŸç€º
ãããšã人è¡æž ã¢ã«ããã³ããŠããããŒãŒããã€
ããªããŒã²ã³ãå ç«æäœã§ããIgGã®åŠãã¿ã³ã
ã¯ããã¬ãªãã€ã·ã³ãã«ããã€ã·ã³ã®åŠãæçç©
質ããã«ã¢ã³é¡ãç³é¡ãèèªé žããã³ãããã®èª
å°äœãæããããããããããããã«éãããç¹
å®èåšãŸãã¯ç¹å®çŸæ£éšäœã«ç¹ç°ãªéç©æ§ã瀺
ãããŸãã¯ãçäœå ã«ãããçççãªè«žç¶æ ã«å¯Ÿ
å¿ããåæ ããšãããã®äœå æåã远跡ããããš
ã«ãããåçš®ã®èšºæã«æçšãªæ å ±ãæäŸããããš
ãæåŸ ããããããªååç©ã§ããã°ãæ¬çºæã«ã
ãããçç掻æ§ååç©ãšããŠäœ¿çšã§ããã ãŸããæ¬çºæã«ããããæŸå°æ§éå±ã«ã€ããŠ
ã¯ãæ žå»åŠèšºæã«æµããç©ççç¹æ§ãæãããã®
ãŸãŸã®åœ¢ã§ããããã¯é©åœãªéå å€ã®ååšäžã«ã
ã¢ããPTSãšå®å®ãªãã¬ãŒãã圢æãããããª
æŸå°æ§éå±ã§ããã°ãããäŸãã°ãã¬ãªãŠã â
67ãã¬ãªãŠã â68ãã€ã³ãžãŠã â111ãã¿ãªãŠã
â201ããã¯ãããŠã â99mãªã©ãçŸåšãæ žå»åŠ
åéã§æ±çšãããŠããæŸå°æ§éå±ãæããããšã
ã§ããã æ¬çºæã®å®æœã«ã€ããŠå ·äœçã«èª¬æãããšäžèš
ã®ããã«ãªãããŸããæ¬çºæã«äœ¿çšããã¢ãã
PTSã®è£œé æ¹æ³ã«ã€ããŠã§ããããäžèšã®åå¿
åŒã§ç€ºãããã«ãçžåœããã¢ãã³èªå°äœ()ã«ç¡
æ°Žããªãããé ¢é žãäœçšãããŠãã¢ããåºãä¿è·
ããã¢ã·ã«æ¬äœ()ãçµç±ããŠãïœâããããªã
ã«èªå°äœ()ãåŸããHoward Newmanã®æ¹æ³
ïŒJ.Org.Chem.30 1287ïŒ1965ïŒã«ãããçé žã«ãª
ãŠã ã§ããªãããã¢ã»ãã«åºãã¯ãããã®ã¡ãçž
åœããã€ãœããããœååç©()ãçµç±ããŠãç®ç
ãšãããžããªã»ãã«ã«ããŸã³èªå°äœ()ãåŸãã
ãšãã§ããã ïŒåŒäžïŒ²ã¯ççŽ æ°ïŒãïŒã®ã¢ã«ãã«åºãããªã
矀ããéžã°ããåºãè¡šãããïœã¯ïŒãïŒ ã®æŽæ°
ãè¡šãããïŒ æ¬¡ã«ãéæŸå°æ§ãã€ãªã€ã«ã€ããŠã§ããããã°
ã«ã¿ã«ã¢ã«ãããæ³ã«ãã補é ã«éããŠã¯ãæ°ŽçŽ
åããŠçŽ ãããªãŠã ã«ããéå å·¥çšã®åã«ãã·ã
ãå¡©åºååç©ãåé¢ããå¿ èŠã¯ãªããé£ç¶çã«é
å å·¥çšã«ç§»ãããšã¯ãªããå·®æ¯ããªããã«ã«ããž
ã€ããæ³ã«ãã補é ã«ãããŠäœ¿çšããã氎溶æ§ã«
ã«ããžã€ããã¯ãïŒâã·ã¯ãããã·ã«âïŒâïŒïŒ
âã¢ã«ããªãã«âïŒâãšãã«ïŒã«ã«ããžã€ãã
ïŒCMCïŒãïŒâãšãã«âïŒâïŒïŒâãžã¡ãã«ã¢ãã
ãããã«ïŒã«ã«ããžã€ããïŒEDCïŒã®ãããªã
äžè¬ã«ãã¿ã³ãã¯ã®ä¿®é£Ÿå€ãšããŠçšãããããã
ãªã«ã«ããžã€ããååç©ãæµããŠãããã°ã«ã¿ã«
ã¢ã«ãããæ³ãã«ã«ããžã€ããæ³ã®ãããã®å Žå
ã«ãããŠããåå¿ã®çµäºåŸã®ç²Ÿè£œã«ã¯ã該çç掻
æ§ç©ã®ååŠçãç©ççæ§è³ªãåæ¡ããŠéžæããã
ã«ã©ã ã¯ãããã°ã©ãæ³ãã²ã«éæ³ãéææ³ãª
ã©ã®éåžžã®ç²Ÿè£œæ³ãæ¡ãããããã®ããã«ããŠåŸ
ãããéæŸå°æ§ãã€ãªã€ã溶液äžã«æº¶ãããããš
ã«ããéæŸå°æ§çµæç©ãåŸãã ãŸããææã«ãããæšèãã¹ãæŸå°æ§éå±ã€ãª
ã³ã®åå䟡ç¶æ ã調ç¯ããããã®éå å€ãããã
ããéæŸå°æ§çµæç©ã«å«æãããŠããããšãã§ã
ããããã§èšãéå å€ãšããŠã¯ãè¬å€åŠäžã容èª
ãããéå å€ã䜿çšããããã奜ãŸããã¯ç¬¬äžã¹
ãºå¡©ãæãããããæ¬çºæã®å®æœã«ãããŠæçšãª
第äžã¹ãºå¡©ã¯äºäŸ¡ã®ã¹ãºã圢æããå¡©ã§ãã€ãŠã
å ·äœçã«ã¯äŸãã°ãå¡©çŽ ã€ãªã³ãããçŽ ã€ãªã³ãª
ã©ã®ããã²ã³é°ã€ãªã³ãç¡«é žã€ãªã³ãç¡é žã€ãªã³
ãªã©ã®è€çŽ ç¡æ©é žæ®åºã€ãªã³ãé ¢é žã€ãªã³ãã¯ãš
ã³é žã€ãªã³ãªã©ã®ææ©é žæ®åºã€ãªã³ã圢æããå¡©
ãèšãã ãã®ããã«ããŠåŸãããéæŸå°æ§çµæç©ã¯ãã
ã®ãŸãŸæº¶æ¶²ã®åœ¢ã§æŸå°æ§éå±ã«ããæšèåã«äŸã
ãŠãããããŸããåçµä¹Ÿç¥æ³ãŸãã¯æ°Žæž©æžå§èžçº
æ³ãªã©ã®æ¹æ³ã«ãã溶åªãé€å»ãã也ç¥åã®åœ¢ã«
ããåŸãæŸå°æ§éå±ã«ããæšèåã«äŸããŠãã
ãã 補é ã«ãã€ããŠãäŸãã°ãpHã調ç¯ãããã
ã®é žãå¡©åºãŸãã¯é©åœãªç·©è¡æ¶²ã®æ·»å ãã¢ã¹ã³ã«
ãã³é žã®åŠãé žåé²æ¢äœçšãæããååç©ã®å®å®
åå€ãšããŠã®æ·»å ããŸãå¡©åãããªãŠã ã®åŠãç
匵åå€ããã³ãžã«ã¢ã«ã³ãŒã«ã®ãããªä¿åå€ãæ·»
å ããããšã¯ãæ¬éæŸå°æ§çµæç©ã®ç®çãšããçš
éããªãã劚ãããã®ã§ã¯ãªãã 次ã«æŸå°æ§éå±æšèã€ãæŸå°æ§èšºæå€ã«ã€ããŠ
ã§ããããéæŸå°æ§çµæç©ãšæ¥è§ŠãããæŸå°æ§é
å±ã€ãªã³ãå«ã氎溶液ãžã®ãpHã調ç¯ãããã
ã®é žãå¡©åºãŸãã¯é©åœãªç·©è¡æ¶²ã®æ·»å ãæŸå°æ§é
å±ã€ãªã³ã®åå䟡ç¶æ ã調ç¯ããããã®éå å€å
ã¯é žåå€ã®æ·»å ãããã³å®å®åå€ãç匵åå€ãä¿
åå€ã®æ·»å ã¯ãæ¬æŸå°æ§éå±æšèã€ãæŸå°æ§èšºæ
å€ã®ç®çãšããçšéããªãã劚ãããã®ã§ã¯ãª
ãã éæŸå°æ§ãã€ãªã€ã®éã«ã€ããŠã¯ãæŸå°æ§éå±
ãšå®å®ãªãã¬ãŒãã圢æããã«å åãªéã§ããã°
ããããã€è¬å€åŠäžèš±å®¹ãããç¯å²ã§ããããšã
æãŸããããšã¯ãããŸã§ããªãããŸããææã«ã
ãå ãããã第äžã¹ãºå¡©ã«ã€ããŠã¯ãæŸå°æ§éå±
ã€ãªã³ãé©åœãªåå䟡ç¶æ ã«éå ããã®ã«å åãª
éã§ããããè¬å€åŠäžèš±å®¹ãããç¯å²ã§ããã°ã
ãã æ¥è§ŠãããæŸå°æ§éå±ã®æŸå°èœã¯ä»»æã§ãã
ããç®çãšããæ žå»åŠèšºæãå®æœããã«éããŠã
å åãªæ å ±ãåŸããããããªæŸå°èœã§ãããã
ã€ã被éšè ã®æŸå°ç·è¢«æãå¯èœãªéãäœãããã
ããªæŸå°èœã®ç¯å²ã§ããããšãæãŸããã®ã¯ãã
ãŸã§ããªãã æäžæ¹æ³ã«ã€ããŠã¯ãäžè¬ã«éèå æäžãè¡ã
ããããæšèãããã¹ãçç掻æ§ååç©ã®æäžåŸ
ãã®æŽ»æ§ãçºçŸãããã«æå©ãªæäžæ¹æ³ã§ããã°
ãããä»ã®æäžæ¹æ³ãå®æœãåŸãã 以äžã«å®æœäŸããããªãããæ¬çºæãããã«å ·
äœçã«èª¬æããã å®æœäŸ ïŒ ïŒâïŒïœâã¢ãããšãã«ïŒããšãã«ãããã³1.2
âãžãªã³âãã¹ïŒïŒâã¡ãã«ããªã»ãã«ã«ããŸ
ã³ïŒã人è¡æž ã¢ã«ããã³ã«çµåãããéæŸå°æ§ã
ã€ãªã€ãå«ãéæŸå°æ§çµæç© äººè¡æž ã¢ã«ããã³ïŒåçµä¹Ÿç¥åïŒ75mgãïŒmlã®
æ°Žã«æº¶è§£ããããã®æº¶æ¶²ã液ãšãããå¥ã«ãïŒ
âïŒïŒ°âã¢ãããšãã«ïŒããšãã«ãããã³âïŒïŒ
ïŒâãžãªã³âãã¹ïŒïŒâã¡ãã«ããªã»ãã«ã«ããŸ
ã³ïŒãïŒmgïŒmlã«ãªãããã«ãžã¡ãã«ãã«ã ã¢ã
ãã«æº¶è§£ãããã®æº¶æ¶²ãã0.5mlãåãã液ã«
å ããã0.1Nå¡©é žæº¶æ¶²ã§pHãçŽ4.6ã«èª¿æŽããã
ãã®æ¶²ã液ãšãããæŽã«ã10mgïŒmlã®æ¿åºŠã®ïŒ
âãšãã«âïŒâïŒïŒâãžã¡ãã«ã¢ãããããã«ïŒ
ã«ã«ããžã€ããå¡©é žå¡©æ°Žæº¶æ¶²1.3mlã液ã«å ã
ãåŸ0.1Nå¡©é žæº¶æ¶²ã§åã³pHãçŽ4.6ã«èª¿æŽããïŒ
â以äžã®æž©åºŠã§çŽ10æéæªæãç¶ããã äžèšæ··å溶液ãéåžžã®éæããŠãŒãäžã«å ¥ãã
åžžæ³ã«ããäžæŒå€éæããã®ã¡ãé å¿åé¢ããå
çµä¹Ÿç¥ããŠãçœè²ã®çµæ¶ã®éæŸå°æ§ãã€ãªã€ãåŸ
ãããã®çµæ¶67mgããçªçŽ ã¬ã¹ãå¹ãããã§æº¶å
é žçŽ ãé€å»ãã0.2Mé ¢é žç·©è¡æ¶²ïŒpHïŒ2.64ïŒïŒ
mlã«æº¶è§£ãã次ãã§ã0.1mMå¡©å第äžã¹ãºæ°Žæº¶
液2.0mlãå ããããã«ã¢ã¹ã³ã«ãã³é ž1.2mgãå
ããå®å šã«æº¶è§£ãããããã®æº¶æ¶²ãååŸ0.22ÎŒm
ã®ãã€ã«ã¿ãŒãéããŠ1.5mlãã€ãå éšãçªçŽ 眮
æãããã€ã¢ã«ã«å å¡«ããç®çãšããéæŸå°æ§çµ
æç©ãåŸãã以äžã®æäœã¯å šãŠç¡èçã«ãããªã€
ãã æ¬å®æœäŸã«ããåŸãããéæŸå°æ§çµæç©ã¯ãã
ãèäºæ·¡é»è²ã®æŸæãªæ¶²ã§ããã å®æœäŸ ïŒ ïŒâïŒïœâã¢ããã¡ãã¬ã³ïŒããšãã«ãããã³
âïŒïŒïŒâãžãªã³âãã¹ïŒïŒâã¡ãã«ããªã»ãã«
ã«ããŸã³ïŒã人è¡æž ã¢ã«ããã³ã«çµåãããéæŸ
å°æ§ãã€ãªã€ãå«ãéæŸå°æ§çµæç© ïŒâïŒïœâã¢ããã¡ãã¬ã³ïŒããšãã«ãããã³
âïŒïŒïŒâãžãªã³âãã¹ïŒïŒâã¡ãã«ããªã»ãã«
ã«ããŸã³ïŒïŒmgãïŒmlã®ãžã¡ãã«ãã«ã ã¢ããã«
溶解ãããã®æº¶æ¶²ã«ãã°ã«ã¿ã«ã¢ã«ããããïŒâ
ïœâïŒã¢ããã¡ãã¬ã³ïŒããšãã«ãããã³âïŒïŒ
ïŒâãžãªã³âãã¹ïŒïŒâã¡ãã«ããªã»ãã«ã«ããŸ
ã³ïŒãçã¢ã«ã«ãªãããã«å ããçŽ15åéã宀枩
ã§æªæããããã®æº¶æ¶²ã液ãšãããå¥ã«ã人è¡
æž ã¢ã«ããã³ïŒåçµä¹Ÿç¥åïŒ100mlã10mlã®
0.01Mãªã³é žç·©è¡æ¶²â0.15Mé£å¡©æ¶²æ··å液ïŒpHïŒ
7.4ïŒã«æº¶è§£ããããã®æº¶æ¶²ã液ãšãããæ°·å·
äžã«æ¶²ã®1.0mlã液ã«å ããåã枩床ã§çŽ30
åéæªæåå¿ããããæŽã«åå¿æ¶²ã«ãæ°ŽçŽ åããŠ
çŽ ãããªãŠã ïŒmgãå ããçŽïŒæéïŒãïŒâã§æª
æããªããéå ãè¡ãªã€ãã åå¿çµäºåŸãåžžæ³ã«ãããæªåå¿è©Šè¬çãé€ã
ãããéåžžã®éæããŠãŒãäžã«å ¥ãã24æééæ
ããéæŸå°æ§ãã€ãªã€ãå«ã溶液ãåŸãåŸãçŽã¡
ã«ã溶液ãååŸ0.22ÎŒmã®ãã€ã«ã¿ãŒãéããŠ1.0
mlãã€ããã€ã¢ã«ã«å å¡«ããåçµä¹Ÿç¥ããããšã«
ãããç®çãšããéæŸå°æ§çµæç©ãåŸãã以äžã®
æäœã¯å šãŠç¡èçã«ãããªã€ãã æ¬å®æœäŸã«ããåŸãããéæŸå°æ§çµæç©ã¯ãæ°Ž
ãå ããŠæº¶è§£ãããšããããèãæ·¡é»è²ã®æŸæãª
液ãäžããã å®æœäŸ ïŒ ïŒâïŒïœâã¢ããã¡ãã¬ã³ïŒããšãã«ãããã³
âïŒïŒïŒâãžãªã³âãã¹ïŒïŒâã¡ãã«ããªã»ãã«
ã«ããŸã³ïŒããŠããããŒãŒã«çµåãããéæŸå°æ§
ãã€ãªã€ãå«ãéæŸå°æ§çµæç© æ°·æµŽäžã粟補ãŠããããŒãŒïŒåçµä¹Ÿç¥åïŒ50mg
ãïŒmlã®æ°Žã«æº¶è§£ããããã®æº¶æ¶²ã液ãšããã
å¥ã«ïŒâïŒïœâã¢ããã¡ãã¬ã³ïŒããšãã«ããã
ã³âïŒïŒïŒâãžãªã³âãã¹ïŒïŒâã¡ãã«ããªã»ã
ã«ã«ããŸã³ïŒãïŒmgïŒmlã«ãªãããã«ãžã¡ãã«ã
ã«ã ã¢ããã«æº¶è§£ãããã®æº¶æ¶²ãã0.5mlãåãã
液ã«å ãããã€ãã§0.1Nå¡©é žæº¶æ¶²ã§pHãçŽ4.6
ã«èª¿æŽããããã®æ¶²ã液ãšãããæŽã«ã50mgïŒ
mlã®æ¿åºŠã®ïŒâã·ã¯ãããã·ã«âïŒâïŒïŒâã¢ã«
ããªãã«âïŒâãšãã«ïŒã«ã«ããžã€ãã氎溶液
1.5mlã液ã«å ããåŸã0.1Nå¡©é žæº¶æ¶²ã§åã³pH
ã4.6ã«èª¿æŽããïŒâ以äžã®æž©åºŠã§çŽïŒæéæªæ
ããã åå¿çµäºåŸãæªåå¿è©Šè¬çãè±å¡©çã«é€ãã
ãã溶åºå€ãšããŠ0.01Mãªã³é žç·©è¡æ¶²â0.15Mé£
塩液混å液ïŒpHïŒ7.4ïŒãçšããåå¿æº¶æ¶²ãã»ã
ã¢ããã¹ã¯ïŒ§â50ïŒïŒÃ30cmã«ã©ã ïŒã«ãããåŸã
ãŠããããŒãŒã«ã€ããŠã5.0mgïŒmlã«ãªãããã«ã
0.01Mãªã³é žç·©è¡æ¶²â0.15Mé£å¡©æ··å液ãçšãåž
éãã次ã«ååŸ0.22ÎŒmã®ãã€ã«ã¿ãŒãéããŠ1.5
mlãã€ããã€ã¢ã«ã«å å¡«ããç®çãšããéæŸå°æ§
çµæç©ãåŸãã以äžã®æäœã¯å šãŠç¡èçã«ãããª
ã€ãã æ¬å®æœäŸã«ããåŸãããéæŸå°æ§çµæç©ã¯ãã
ãèãæ·¡é»è²ã®æŸæãªæ¶²ã§ããã å®æœäŸ ïŒ ãã¯ãããŠã â99mæšèã€ãæŸå°æ§èšºæå€ã®è£œ
é å®æœäŸïŒã®æ¹æ³ã«ãã€ãŠåŸãéæŸå°æ§çµæç©ã®
1.0mlããéãã¯ãããŠã é žãããªãŠã ã®åœ¢ã§ã
ã¯ãããŠã â99mã3mCiãå«ãççé£å¡©æ°Žæº¶æ¶²
0.5mlãšæ··åããããæªæããããšã«ããããã¯
ãããŠã â99mæšèã€ãæŸå°æ§èšºæå€ãåŸãã æ¬å®æœäŸã§åŸããããã¯ãããŠã â99mæšèã€
ãæŸå°æ§èšºæå€ã¯ãããèãæ·¡é»è²ã®æŸæãªæ¶²ã§
ãããpHã¯çŽ3.0ã§ããã å®æœäŸ ïŒ ã¬ãªãŠã â67æšèã€ãæŸå°æ§èšºæå€ã®è£œé å®æœäŸïŒã®æ¹æ³ã«ãã€ãŠè£œé ãããéæŸå°æ§çµ
æç©ã0.2Mé ¢é žç·©è¡æ¶²ïŒpHïŒ4.0ïŒ1.0mlã§å®å š
ã«æº¶è§£ãã次ãã§å¡©åã¬ãªãŠã ãšããŠãã¬ãªãŠã
â67ã2mciãå«æãã0.01Nå¡©é žæº¶æ¶²0.5mlãå
ããŠãã¬ãªãŠã â67æšèã€ãæŸå°æ§èšºæå€ãåŸ
ãã æ¬å®æœäŸã§åŸãããã¬ãªãŠã â67æšèã€ãæŸå°
æ§èšºæå€ã¯ãããèãæ·¡é»è²ã®æŸæãªæ¶²ã§ããã
pHã¯çŽ3.7ã§ããã å®æœäŸ ïŒ ãã¯ãããŠã â99mæšèã€ãæŸå°æ§èšºæå€ã®æ§
質 å®æœäŸïŒã®æ¹æ³ã§è£œé ããããã¯ãããŠã â
99mæšèã€ãæŸå°æ§èšºæå€ã®æšèçã調ã¹ãã
ããã·ãªã«ã²ã«ãä¿æå±€ãšããã¡ãã«ãšãã«ã±ã
ã³ãå±é溶åªãšããèå±€ã¯ãããã°ã©ãã€ãŒãã
ããªããã©ãžãªã¯ãããã¹ãã€ããŒã§èµ°æ»ããã
æŸå°èœã¯åç¹ã«åäžãªããŒã¯ãšããŠæåºãããé
é¢ã®éã¹ã¯ãããŠã é žã€ãªã³ã«çžåœããæŸå°èœã
ãŒã¯ïŒRfïŒ1.0ïŒãªã©æŸå°æ§å€Ÿéç©ã®ååšãèªã
ãªãã€ãã 次ãã§ãããããŒã«ç·©è¡æ¶²ïŒpHïŒ8.6ïŒãå±é
液ãšããã»ã«ããŒã¹ã¢ã»ããŒããæ³³åèãšããé»
æ°æ³³åïŒ1.7mAïŒcmã15åïŒããããªã€ãåŸãã©
ãžãªã¯ãããã¹ãã€ããŒã§èµ°æ»ãããæŸå°èœã®äœ
眮ã¯ãåç·ããæ£åŽã«1.8cmã®å Žæã«åäžããŒã¯
ãšããŠèªãããã€ããã®æŸå°èœããŒã¯ã®äœçœ®ã¯ã
ãã³ãœãŒ3Rã«ãã人è¡æž ã¢ã«ããã³ã®çºè²ãã³
ããšäžèŽããã äžèšã®çµæãããæ¬çºæã®æ¹æ³ã§è£œé ãããã
ã¯ãããŠã â99mæšèã€ãæŸå°æ§èšºæå€ã®æšèç
ã¯ãã»ãŒ100ïŒ ã§ããããã€ããã®é»è·ç¶æ ã«ã€
ããŠã人è¡æž ã¢ã«ããã³ãšå·®ç°ãèªããªã€ãã å®æœäŸ ïŒ ãã¯ãããŠã â99mæšèã€ãæŸå°æ§èšºæå€ã®å
ç©äœå ååž å®æœäŸïŒã®æ¹æ³ã§è£œé ããããã¯ãããŠã â
99mæšèã€ãæŸå°èšºæå€ã®åã 0.1mlãã€ããšãã
è€æ°ã®S.D.ç³»éã©ããã®å°Ÿéèã«æäžããè¡äžæ¿
床ã®çµæå€åã調ã¹ããå¯Ÿç §ãšããŠåŸæ¥ã®æ¹æ³ã§
ãã¯ãããŠã â99mãçŽæ¥æšèãããã¯ãããŠã
â99mæšè人è¡æž ã¢ã«ããã³ããã³ãšãŒããŒ131
ã§æšèãããšãŒããŒ131æšè人è¡æž ã¢ã«ããã³ã«
ã€ããŠãåæ§ã®è©Šéšããããªãæ¯èŒãããè¡äžæ¿
床ã®çµ¶å¯Ÿå€ïŒïŒ æäžéïŒïœïŒå¹³åå€ïŒã®æšç§»ãã
ããã¯ããŠã â99mã§çŽæ¥æšèãããã¯ããã ãŠ
â99mæšè人å€æž ã¢ã«ããã³ããã³ãšãŒããŒ131
æšè人è¡æž ã¢ã«ããã³ãšå ±ã«æ¬¡è¡šã«ç€ºãã
ãã³çç掻æ§ååç©ã®åæ æ€æ»ãªã©ãç®çãšãã
æ žå»åŠççšéã«æçšãªãæ°ããå®å®ãªæŸå°æ§éå±
æšèã€ãæŸå°æ§èšºæå€ã«é¢ãããã®ã§ãããããª
ãã¡ãæ¬çºæã¯ã ååŠåŒ ïŒåŒäžïŒ²ã¯ççŽ æ°ïŒãïŒã®ã¢ã«ãã«åºãããªã
矀ããéžã°ããåºãè¡šãããïœã¯ïŒãïŒ ã®æŽæ°
ãè¡šãããïŒ ã§ç€ºãããããªã»ãã«ã«ããŸã³èªå°äœïŒä»¥äžãã
ããç·ç§°ããŠãã¢ããPTSãšç¥ç§°ããïŒããç¹
å®èåšããã³ç¹å®çŸæ£éšäœãžã®å±åšæ§ãæããç
ç掻æ§ååç©ãšçµåãããŠåœ¢æããããšãããªã
ååç©ïŒä»¥äžéæŸå°æ§ãã€ãªã€ãšç¥ãïŒãå«ãã
ãšãç¹åŸŽãšããéæŸå°æ§çµæç©ã«é¢ãããã®ã§ã
ãããŸãä»ã®ç¹ããã¯ãã¢ããPTSã該çç掻
æ§ååç©ãçµåãããŠåœ¢æããããšãããªãéæŸ
å°æ§ãã€ãªã€ãå«ãããšãç¹åŸŽãšããéæŸå°æ§çµ
æç©ããæŸå°æ§éå±ã€ãªã³ãå«æãã溶液ãšæ¥è§Š
ãããŠåœ¢æããããšãããªãæŸå°æ§éå±æšèã€ã
å®å®ãªæŸå°æ§èšºæå€ã«é¢ãããã®ã§ããã ç¹å®èåšã®æåºãç¹å®çŸæ£ã®æ€åºããã³åæ æ€
æ»ãªã©ãç®çãšããé䟵襲çæ žå»åŠèšºæã®ãã
ã«ãåŸæ¥ããšãŒããŒ131ã§æšèãããçç掻æ§å
åç©ãæ±çšãããŠæ¥ããäŸãã°ãè¡æ¶²åŸªç°ç³»ã®æ
åºããã³åæ æ€æ»ã«çšãããããšãŒããŒ131æšè
人è¡æž ã¢ã«ããã³ãè¡æ ã®æ€åºãç®çãšãããšãŒ
ããŒ131æšèãã€ããªããŒã²ã³ãªã©ãæããããã
ããããªããããšãŒããŒ131ã¯ãåæžæãçŽïŒæ¥
ãšé·ãããã€ãæ žå»åŠèšºæã«æçšãªã¬ã³ãç·ã®ä»
ã«ãããŒã¿ç·ãæŸåºããããã被éšè ã«å€éã®æŸ
å°ç·è¢«æãäžããæ¬ ç¹ãããããšãææãããŠã
ãã æ žå»åŠèšºæã«ããæµããç©ççç¹æ§ãæããæŸ
å°æ§éå±ãä»ã®æ¹æ³ã«ããçç掻æ§ååç©ã«å°å ¥
ããæçšãªæŸå°æ§èšºæå€ãåŸãããšããè©Šã¿ãç¶
ããããŠãããããªãã¡ããã¬ãŒãçµåã®åœ¢æã
æåŸ ããŠãçç掻æ§ååç©ã«çŽæ¥ãæŸå°æ§éå±å¡©
ãäœçšãããŠãããªãæšèæ³ã§ãããäŸãã°ã人
è¡æž ã¢ã«ããã³ã«é©åœãªéå å€ã®ååšäžã«ãéã
ã¯ãããŠã é žå¡©ã®åœ¢ã§ãã¯ãããŠã â99mãå«ã
氎溶液ãäœçšãããŠããã¯ãããŠã â99mæšè人
è¡æž ã¢ã«ããã³ãåŸãæ¹æ³ããã¬ãªãã€ã·ã³ã«ã
å¡©åã€ã³ãžãŠã ã®åœ¢ã§ã€ã³ãžãŠã â111ãå«ãæ°Ž
溶液ãäœçšãããŠãã€ã³ãžãŠã â111æšèãã¬ãª
ãã³ã·ã³ãåŸãæ¹æ³ãªã©ãããã«ããããããã
ãªãããããããæšèãããã¹ãçç掻æ§ååç©
ã®ãã¬ãŒã圢ææ§ã¯ãå¿ ããã倧ãããªããåèš
ã®ãã¯ãããŠã â99mæšè人è¡æž ã¢ã«ããã³ãã€
ã³ãžãŠã â111æšèãã¬ãªãã³ã·ã³ã®å Žåã«ãã
ãŠããäœå æäžåŸã®å®å®æ§ãäœããæŸå°èœã®äœå
æåããçç掻æ§ååç©ã®æåãšäžèŽãããæ žå»
åŠèšºæãç®çãšããçšéã«ãããŠãæºè¶³ãã¹ãã
ã®ã§ã¯ãªãããšãææãããŠããã ããã§èšãçç掻æ§ååç©ãšã¯ãç¹å®èåšãŸã
ã¯ç¹å®æ£éšäœã«ç¹ç°ãªéç©æ§ã瀺ãããŸãã¯ãç
äœå ã«ãããçççãªè«žç¶æ ã«å¯Ÿå¿ããç¹ç°ãªå
æ ããšããããªååç©ãæããã®ã§ããããã®äœ
å æåã远跡ããããšã«ãããåçš®ã®èšºæã«æçš
ãªæ å ±ãæäŸããããšãæåŸ ããããããªååç©
ã§ããããã®ãããªçç掻æ§ååç©ã«ãåªããç©
ççç¹æ§ãæããæŸå°æ§éå±ãå®å®ã«ããããã
該ååç©ã®çç掻æ§ããããªãããšãªãå°å ¥ãã
ããšãã§ããã°ãæ žå»åŠèšºæã«ãããŠã極ããŠæ
çšãªãããšãæåŸ ãããæ žå»åŠçã«ãããŠãã®ã
ããªæŸå°æ§èšºæå€ã®åºçŸã匷ãèŠæãããŠãããš
ããã§ããã æ¬çºæè ãã¯ãå ã«ãåæ§ã®åºæ¬çæ§æ³ã§ç 究
ãé²ããçµæãïŒâãªããœããã©âã«ãã¹ïŒïŒ®â
ã¡ãã«ããªã»ãã«ã«ããŸã³ïŒã«ã«ãã³é žãèŠãåº
ããïŒç¹æé56â34664ïŒãããããªããããã®å
åç©ã®çç掻æ§ç©è³ªã«å¯Ÿããåå¿æªç«¯ã¯ãã«ã«ã
ã³é žã§ãããæ¬çºæã®ã¢ããPTSïŒåå¿æªç«¯ã¢ã
ãåºïŒãšã¯ãçç掻æ§ç©è³ªãšã®çµåã®ããã®åå¿
æ¹æ³ãªã©ããã®ããšç°ãªããã®ã§ããããŸããäž
ç°ãã¯ãæ¬çºæè ããšåãåºæ¬çèãæ¹ã«ããç
究ãé²ããïŒâã¢ããã¡ãã¬ã³â2.4âãã³ã¿ã³
ãžãªã³âãã¹ïŒããªã»ãã«ã«ããŸã³ïŒããã³ãã®
èªå°äœãæçšã§ãããšããŠããïŒç¹éæ57â
102860ïŒãããã®æ§é åŒããå€æããŠã(1)ãã¬ãŒ
ã圢æåºãšãçç掻æ§ç©è³ªã«å¯Ÿããåå¿æ«ç«¯ïŒã¢
ããåºïŒãããŸãã«ã¯æ¥è¿ããŠããããšã(2)åå¿
æ«ç«¯ã§ããã¢ããåºããäºéçµåãæããççŽ ã«
çµåããŠãããããã¢ããåºçªçŽ äžã®é»åå¯åºŠã
äœãããšãçã«ãããçç掻æ§ç©è³ªãšã®åå¿æ§ã«
åé¡ç¹ããªãããšäºæ³ãããã æ¬çºæã®ç®çã¯ãåèšã®èŠæã«å¿ããŠãåçš®ã®
çç掻æ§ååç©ã®ãåªããç©ççæ§è³ªãæã€æŸå°
æ§éå±æšèååç©ã§ãããããªããã€ãå®å®ã§ã
ããæŽã«ã¯ããã容æãªææ³ã«ãã€ãŠåŸãããã
ããªãæŽã«ã¯ã該çç掻æ§ååç©ã®æŽ»æ§ãä¿æã
ãæšèååç©ã§ãããããªæŸå°æ§èšºæå€ãæäŸã
ãããšã«ããã æ¬çºæè ãã¯ãã¢ããPTSã®åŒ·ããã¬ãŒã圢
æèœåãšãçç掻æ§ååç©ã®ã¢ããåºãããã¯ã«
ã«ããã·åºãšç©åãªæ¡ä»¶äžã§çµåããèœåãæã
ãã¢ããåºããã€ãšããç¹ã«çç®ããå®éšæ€èšã
å ããçµæãéåžžã«åªããéæŸå°æ§çµæç©ããã³
æŸå°æ§èšºæå€ã補é ããåŸããšãçºèŠããã ããªãã¡ãã¢ããPTSãã氎溶æ§ã«ã«ããžã€
ããã®ååšäžã«ã«ã«ããã·ã«åºãæããçç掻æ§
ååç©ãšæ¥è§Šããããšãã極ããŠç©åãªæ¹æ³ã«ã
ã€ãŠçç掻æ§ååç©ã®å€æ§ããã³å€±æŽ»ããšããªã
ããšãªããã¢ããPTSã®æ«ç«¯ã¢ããåºãä»ããŠ
çç掻æ§ååç©ãšã®éã«ååŠçµåã圢æãããã
éåžžã«åŒ·ããã¬ãŒã圢æèœãæã€ãéæŸå°æ§ãã€
ãªã€ã補é ãããããšãèŠãåºããããŸããã¢ã
ãPTSãã¢ããåºãæããŠãããšããå©ç¹ãç
ãããŠãã¢ããåºãæããçç掻æ§ååç©ã«å¯Ÿã
ãŠããã¿ã³ãã¯ã®ååŠä¿®é£Ÿæ³ãšããŠéåžžçšããã
ãã°ã«ã¿ã«ã¢ã«ãããæ³ã«ãããã°ã«ã¿ã«ã¢ã«ã
ãããã¢ããPTSãšã¢ããåºãæããçç掻æ§
ååç©ãšã®æ¶æ©ç©è³ªãšããŠãã·ããå¡©åºã圢æã
ããããã«æ°ŽçŽ åããŠçŽ ãããªãŠã çã®éå å€ã
äœçšãããããšã«ãã€ãŠæ¥µããŠå®å®ãªéæŸå°æ§ã
ã€ãªã¢ã補é ãåŸãããšãèŠãåºãããã€ãã§ã
ãããã®éæŸå°æ§ãã€ãªã¢ãå«ãéæŸå°çµæç©ã«
æŸå°æ§éå±ã€ãªã³ãå«ã氎溶液ãæ¥è§Šããããšã
ã極ããŠç°¡äŸ¿ãªæ¹æ³ã«ãã€ãŠãæŸå°æ§éå±æšèã€
ãçç掻æ§ååç©ã§ãããããªæŸå°æ§èšºæå€ã補
é ãåŸãããšãèŠãåºããã ãªããæ žå»åŠèšºæã«ãããŠæ±çšãããéãã¯ã
ããŠã é žå¡©ã®åœ¢ã§åžè²©ãããŠãããã¯ãããŠã â
99mãªã©ã®æŸå°æ§éå±ã€ãªã³ã®ããã«ããã®ãŸãŸ
ã®åå䟡ç¶æ ã§ã¯åèšã®éæŸå°æ§ãã€ãªã€ãšåŒ·åº
ã«çµåããªãå Žåããã®ãããªæŸå°æ§éå±ã€ãªã³
ãã匷åºãªçµåã®åœ¢æã«æå©ãªäœåå䟡ç¶æ ã«é
å ããããã«ã第äžã¹ãºå¡©çã®éå å€ããã®ãŸãŸ
ã®åœ¢ã§ããŸãã¯ã€ãªã³äº€ææš¹èã«åžçããã圢ã§
ãããããéæŸå°æ§çµæç©äžã«å«æãããŠãã
ã°ãåè¿°ãšåæ§ã®ç°¡äŸ¿ãªæ¹æ³ã«ããæŸå°æ§éå±æš
èã€ãæŸå°æ§èšºæå€ã補é ãåŸãã æ¬çºæã®æ¹æ³ã«ãã補é ãããéæŸå°æ§çµæç©
ããã³æŸå°æ§èšºæå€ã¯ãç¹å®èåšã®æåºãç¹å®çŸ
æ£ã®æ€åºããã³åæ æ€æ»ãç®çãšããæ žå»åŠççš
éã«æ¥µããŠæçšãªå©ç¹ãæããã ãŸãéæŸå°æ§ãã€ãªã€ããã³éæŸå°æ§ãã€ãªã€
ãå«ãéæŸå°æ§çµæç©ã®ç¹é·ã«ã€ããŠè¿°ã¹ããšä»¥
äžã®ããšãã§ããã (a) 補é åŸãå åãªæéãå®å®ã§ããã (b) ã¢ããPTSãæ«ç«¯ã¢ããåºãæããããã
äžè¬ã«ã¿ã³ãã¯ã®ååŠä¿®é£Ÿæ³ã«çšãããã極ã
ãŠç·©åãªæ¹æ³ã«ãã補é ãåŸãã®ã§ãçç掻æ§
ååç©ã®å€±æŽ»ãå€æ§ãå解ãªã©å¥œãŸãããªãå¯
åå¿ããšããªããªãã (c) çç掻æ§ååç©ã®ååäžã«ãã¢ããåºãŸãã¯
ã¢ã«ããã·ã«åºã®ãããããæããŠããã°ã容
æã«ç®çãšããéæŸå°æ§ãã€ãªã€ã補é ãåŸ
ãã (d) ã¢ããåºãã«ã«ããã·ã«åºãæããªãçç掻
æ§ååç©ã®å Žåã«ã¯ãé©åœãªæ¹æ³ã«ããã¢ãã
åºãŸãã¯ã«ã«ããã·ã«åºãå°å ¥ããçç掻æ§å
åç©èªå°äœãåé§äœãšããŠçšæããããšã«ã
ããåæ§ã«éæŸå°æ§ãã€ãªã€ã補é ãåŸãã (e) æŸå°æ§éå±ã€ãªã³ãå«ã氎溶液ãæ¥è§Šããã
ãšããæäœã ãã§æ¥µããŠç°¡äŸ¿ã«æŸå°æ§éå±æšè
ã€ãæŸå°æ§èšºæå€ã調補ããããšãã§ããã 次ã«ãæŸå°æ§éå±æšèã€ãæŸå°æ§èšºæå€ã«ã€ã
ãŠã®ç¹é·ããããã°ã以äžã®ããšãã§ããã (a) 補é åŸãå åãªæéãå®å®ã§ããã (b) æŸå°æ§éå±ã«ããæšèçã¯ã»ãŒ100ïŒ ã§ãã
極ããŠé«ãã (c) æšèæäœã«ãããçç掻æ§ååç©ã®å€±æŽ»ãå€
æ§ãå解ãªã©ã®å¥œãŸãããªãå¯åå¿ã¯ãšããªã
ãªãã (d) åæžæãæŸåºã¬ã³ãç·ãšãã«ã®ãŒãªã©ã®ç©ç
çç¹æ§ã®é¢ã§æ žå»åŠèšºæã«æµããçš®ã ã®æŸå°æ§
éå±ã®ãã¡ãããç®çãšããæ žå»åŠç蚺æã«æ
ãæµããæŸå°æ§éå±ãéžã¶ããšãã§ããããã
ã€ãŠãæ žå»åŠèšºæã«ãããæ å ±éã粟床ãåäž
ããããã€æ£è ã®è¢«æç·éã軜æžããããšãã§
ããã æ¬çºæã«ããããçç掻æ§ååç©ã«ã€ããŠäŸç€º
ãããšã人è¡æž ã¢ã«ããã³ããŠããããŒãŒããã€
ããªããŒã²ã³ãå ç«æäœã§ããIgGã®åŠãã¿ã³ã
ã¯ããã¬ãªãã€ã·ã³ãã«ããã€ã·ã³ã®åŠãæçç©
質ããã«ã¢ã³é¡ãç³é¡ãèèªé žããã³ãããã®èª
å°äœãæããããããããããããã«éãããç¹
å®èåšãŸãã¯ç¹å®çŸæ£éšäœã«ç¹ç°ãªéç©æ§ã瀺
ãããŸãã¯ãçäœå ã«ãããçççãªè«žç¶æ ã«å¯Ÿ
å¿ããåæ ããšãããã®äœå æåã远跡ããããš
ã«ãããåçš®ã®èšºæã«æçšãªæ å ±ãæäŸããããš
ãæåŸ ããããããªååç©ã§ããã°ãæ¬çºæã«ã
ãããçç掻æ§ååç©ãšããŠäœ¿çšã§ããã ãŸããæ¬çºæã«ããããæŸå°æ§éå±ã«ã€ããŠ
ã¯ãæ žå»åŠèšºæã«æµããç©ççç¹æ§ãæãããã®
ãŸãŸã®åœ¢ã§ããããã¯é©åœãªéå å€ã®ååšäžã«ã
ã¢ããPTSãšå®å®ãªãã¬ãŒãã圢æãããããª
æŸå°æ§éå±ã§ããã°ãããäŸãã°ãã¬ãªãŠã â
67ãã¬ãªãŠã â68ãã€ã³ãžãŠã â111ãã¿ãªãŠã
â201ããã¯ãããŠã â99mãªã©ãçŸåšãæ žå»åŠ
åéã§æ±çšãããŠããæŸå°æ§éå±ãæããããšã
ã§ããã æ¬çºæã®å®æœã«ã€ããŠå ·äœçã«èª¬æãããšäžèš
ã®ããã«ãªãããŸããæ¬çºæã«äœ¿çšããã¢ãã
PTSã®è£œé æ¹æ³ã«ã€ããŠã§ããããäžèšã®åå¿
åŒã§ç€ºãããã«ãçžåœããã¢ãã³èªå°äœ()ã«ç¡
æ°Žããªãããé ¢é žãäœçšãããŠãã¢ããåºãä¿è·
ããã¢ã·ã«æ¬äœ()ãçµç±ããŠãïœâããããªã
ã«èªå°äœ()ãåŸããHoward Newmanã®æ¹æ³
ïŒJ.Org.Chem.30 1287ïŒ1965ïŒã«ãããçé žã«ãª
ãŠã ã§ããªãããã¢ã»ãã«åºãã¯ãããã®ã¡ãçž
åœããã€ãœããããœååç©()ãçµç±ããŠãç®ç
ãšãããžããªã»ãã«ã«ããŸã³èªå°äœ()ãåŸãã
ãšãã§ããã ïŒåŒäžïŒ²ã¯ççŽ æ°ïŒãïŒã®ã¢ã«ãã«åºãããªã
矀ããéžã°ããåºãè¡šãããïœã¯ïŒãïŒ ã®æŽæ°
ãè¡šãããïŒ æ¬¡ã«ãéæŸå°æ§ãã€ãªã€ã«ã€ããŠã§ããããã°
ã«ã¿ã«ã¢ã«ãããæ³ã«ãã補é ã«éããŠã¯ãæ°ŽçŽ
åããŠçŽ ãããªãŠã ã«ããéå å·¥çšã®åã«ãã·ã
ãå¡©åºååç©ãåé¢ããå¿ èŠã¯ãªããé£ç¶çã«é
å å·¥çšã«ç§»ãããšã¯ãªããå·®æ¯ããªããã«ã«ããž
ã€ããæ³ã«ãã補é ã«ãããŠäœ¿çšããã氎溶æ§ã«
ã«ããžã€ããã¯ãïŒâã·ã¯ãããã·ã«âïŒâïŒïŒ
âã¢ã«ããªãã«âïŒâãšãã«ïŒã«ã«ããžã€ãã
ïŒCMCïŒãïŒâãšãã«âïŒâïŒïŒâãžã¡ãã«ã¢ãã
ãããã«ïŒã«ã«ããžã€ããïŒEDCïŒã®ãããªã
äžè¬ã«ãã¿ã³ãã¯ã®ä¿®é£Ÿå€ãšããŠçšãããããã
ãªã«ã«ããžã€ããååç©ãæµããŠãããã°ã«ã¿ã«
ã¢ã«ãããæ³ãã«ã«ããžã€ããæ³ã®ãããã®å Žå
ã«ãããŠããåå¿ã®çµäºåŸã®ç²Ÿè£œã«ã¯ã該çç掻
æ§ç©ã®ååŠçãç©ççæ§è³ªãåæ¡ããŠéžæããã
ã«ã©ã ã¯ãããã°ã©ãæ³ãã²ã«éæ³ãéææ³ãª
ã©ã®éåžžã®ç²Ÿè£œæ³ãæ¡ãããããã®ããã«ããŠåŸ
ãããéæŸå°æ§ãã€ãªã€ã溶液äžã«æº¶ãããããš
ã«ããéæŸå°æ§çµæç©ãåŸãã ãŸããææã«ãããæšèãã¹ãæŸå°æ§éå±ã€ãª
ã³ã®åå䟡ç¶æ ã調ç¯ããããã®éå å€ãããã
ããéæŸå°æ§çµæç©ã«å«æãããŠããããšãã§ã
ããããã§èšãéå å€ãšããŠã¯ãè¬å€åŠäžã容èª
ãããéå å€ã䜿çšããããã奜ãŸããã¯ç¬¬äžã¹
ãºå¡©ãæãããããæ¬çºæã®å®æœã«ãããŠæçšãª
第äžã¹ãºå¡©ã¯äºäŸ¡ã®ã¹ãºã圢æããå¡©ã§ãã€ãŠã
å ·äœçã«ã¯äŸãã°ãå¡©çŽ ã€ãªã³ãããçŽ ã€ãªã³ãª
ã©ã®ããã²ã³é°ã€ãªã³ãç¡«é žã€ãªã³ãç¡é žã€ãªã³
ãªã©ã®è€çŽ ç¡æ©é žæ®åºã€ãªã³ãé ¢é žã€ãªã³ãã¯ãš
ã³é žã€ãªã³ãªã©ã®ææ©é žæ®åºã€ãªã³ã圢æããå¡©
ãèšãã ãã®ããã«ããŠåŸãããéæŸå°æ§çµæç©ã¯ãã
ã®ãŸãŸæº¶æ¶²ã®åœ¢ã§æŸå°æ§éå±ã«ããæšèåã«äŸã
ãŠãããããŸããåçµä¹Ÿç¥æ³ãŸãã¯æ°Žæž©æžå§èžçº
æ³ãªã©ã®æ¹æ³ã«ãã溶åªãé€å»ãã也ç¥åã®åœ¢ã«
ããåŸãæŸå°æ§éå±ã«ããæšèåã«äŸããŠãã
ãã 補é ã«ãã€ããŠãäŸãã°ãpHã調ç¯ãããã
ã®é žãå¡©åºãŸãã¯é©åœãªç·©è¡æ¶²ã®æ·»å ãã¢ã¹ã³ã«
ãã³é žã®åŠãé žåé²æ¢äœçšãæããååç©ã®å®å®
åå€ãšããŠã®æ·»å ããŸãå¡©åãããªãŠã ã®åŠãç
匵åå€ããã³ãžã«ã¢ã«ã³ãŒã«ã®ãããªä¿åå€ãæ·»
å ããããšã¯ãæ¬éæŸå°æ§çµæç©ã®ç®çãšããçš
éããªãã劚ãããã®ã§ã¯ãªãã 次ã«æŸå°æ§éå±æšèã€ãæŸå°æ§èšºæå€ã«ã€ããŠ
ã§ããããéæŸå°æ§çµæç©ãšæ¥è§ŠãããæŸå°æ§é
å±ã€ãªã³ãå«ã氎溶液ãžã®ãpHã調ç¯ãããã
ã®é žãå¡©åºãŸãã¯é©åœãªç·©è¡æ¶²ã®æ·»å ãæŸå°æ§é
å±ã€ãªã³ã®åå䟡ç¶æ ã調ç¯ããããã®éå å€å
ã¯é žåå€ã®æ·»å ãããã³å®å®åå€ãç匵åå€ãä¿
åå€ã®æ·»å ã¯ãæ¬æŸå°æ§éå±æšèã€ãæŸå°æ§èšºæ
å€ã®ç®çãšããçšéããªãã劚ãããã®ã§ã¯ãª
ãã éæŸå°æ§ãã€ãªã€ã®éã«ã€ããŠã¯ãæŸå°æ§éå±
ãšå®å®ãªãã¬ãŒãã圢æããã«å åãªéã§ããã°
ããããã€è¬å€åŠäžèš±å®¹ãããç¯å²ã§ããããšã
æãŸããããšã¯ãããŸã§ããªãããŸããææã«ã
ãå ãããã第äžã¹ãºå¡©ã«ã€ããŠã¯ãæŸå°æ§éå±
ã€ãªã³ãé©åœãªåå䟡ç¶æ ã«éå ããã®ã«å åãª
éã§ããããè¬å€åŠäžèš±å®¹ãããç¯å²ã§ããã°ã
ãã æ¥è§ŠãããæŸå°æ§éå±ã®æŸå°èœã¯ä»»æã§ãã
ããç®çãšããæ žå»åŠèšºæãå®æœããã«éããŠã
å åãªæ å ±ãåŸããããããªæŸå°èœã§ãããã
ã€ã被éšè ã®æŸå°ç·è¢«æãå¯èœãªéãäœãããã
ããªæŸå°èœã®ç¯å²ã§ããããšãæãŸããã®ã¯ãã
ãŸã§ããªãã æäžæ¹æ³ã«ã€ããŠã¯ãäžè¬ã«éèå æäžãè¡ã
ããããæšèãããã¹ãçç掻æ§ååç©ã®æäžåŸ
ãã®æŽ»æ§ãçºçŸãããã«æå©ãªæäžæ¹æ³ã§ããã°
ãããä»ã®æäžæ¹æ³ãå®æœãåŸãã 以äžã«å®æœäŸããããªãããæ¬çºæãããã«å ·
äœçã«èª¬æããã å®æœäŸ ïŒ ïŒâïŒïœâã¢ãããšãã«ïŒããšãã«ãããã³1.2
âãžãªã³âãã¹ïŒïŒâã¡ãã«ããªã»ãã«ã«ããŸ
ã³ïŒã人è¡æž ã¢ã«ããã³ã«çµåãããéæŸå°æ§ã
ã€ãªã€ãå«ãéæŸå°æ§çµæç© äººè¡æž ã¢ã«ããã³ïŒåçµä¹Ÿç¥åïŒ75mgãïŒmlã®
æ°Žã«æº¶è§£ããããã®æº¶æ¶²ã液ãšãããå¥ã«ãïŒ
âïŒïŒ°âã¢ãããšãã«ïŒããšãã«ãããã³âïŒïŒ
ïŒâãžãªã³âãã¹ïŒïŒâã¡ãã«ããªã»ãã«ã«ããŸ
ã³ïŒãïŒmgïŒmlã«ãªãããã«ãžã¡ãã«ãã«ã ã¢ã
ãã«æº¶è§£ãããã®æº¶æ¶²ãã0.5mlãåãã液ã«
å ããã0.1Nå¡©é žæº¶æ¶²ã§pHãçŽ4.6ã«èª¿æŽããã
ãã®æ¶²ã液ãšãããæŽã«ã10mgïŒmlã®æ¿åºŠã®ïŒ
âãšãã«âïŒâïŒïŒâãžã¡ãã«ã¢ãããããã«ïŒ
ã«ã«ããžã€ããå¡©é žå¡©æ°Žæº¶æ¶²1.3mlã液ã«å ã
ãåŸ0.1Nå¡©é žæº¶æ¶²ã§åã³pHãçŽ4.6ã«èª¿æŽããïŒ
â以äžã®æž©åºŠã§çŽ10æéæªæãç¶ããã äžèšæ··å溶液ãéåžžã®éæããŠãŒãäžã«å ¥ãã
åžžæ³ã«ããäžæŒå€éæããã®ã¡ãé å¿åé¢ããå
çµä¹Ÿç¥ããŠãçœè²ã®çµæ¶ã®éæŸå°æ§ãã€ãªã€ãåŸ
ãããã®çµæ¶67mgããçªçŽ ã¬ã¹ãå¹ãããã§æº¶å
é žçŽ ãé€å»ãã0.2Mé ¢é žç·©è¡æ¶²ïŒpHïŒ2.64ïŒïŒ
mlã«æº¶è§£ãã次ãã§ã0.1mMå¡©å第äžã¹ãºæ°Žæº¶
液2.0mlãå ããããã«ã¢ã¹ã³ã«ãã³é ž1.2mgãå
ããå®å šã«æº¶è§£ãããããã®æº¶æ¶²ãååŸ0.22ÎŒm
ã®ãã€ã«ã¿ãŒãéããŠ1.5mlãã€ãå éšãçªçŽ 眮
æãããã€ã¢ã«ã«å å¡«ããç®çãšããéæŸå°æ§çµ
æç©ãåŸãã以äžã®æäœã¯å šãŠç¡èçã«ãããªã€
ãã æ¬å®æœäŸã«ããåŸãããéæŸå°æ§çµæç©ã¯ãã
ãèäºæ·¡é»è²ã®æŸæãªæ¶²ã§ããã å®æœäŸ ïŒ ïŒâïŒïœâã¢ããã¡ãã¬ã³ïŒããšãã«ãããã³
âïŒïŒïŒâãžãªã³âãã¹ïŒïŒâã¡ãã«ããªã»ãã«
ã«ããŸã³ïŒã人è¡æž ã¢ã«ããã³ã«çµåãããéæŸ
å°æ§ãã€ãªã€ãå«ãéæŸå°æ§çµæç© ïŒâïŒïœâã¢ããã¡ãã¬ã³ïŒããšãã«ãããã³
âïŒïŒïŒâãžãªã³âãã¹ïŒïŒâã¡ãã«ããªã»ãã«
ã«ããŸã³ïŒïŒmgãïŒmlã®ãžã¡ãã«ãã«ã ã¢ããã«
溶解ãããã®æº¶æ¶²ã«ãã°ã«ã¿ã«ã¢ã«ããããïŒâ
ïœâïŒã¢ããã¡ãã¬ã³ïŒããšãã«ãããã³âïŒïŒ
ïŒâãžãªã³âãã¹ïŒïŒâã¡ãã«ããªã»ãã«ã«ããŸ
ã³ïŒãçã¢ã«ã«ãªãããã«å ããçŽ15åéã宀枩
ã§æªæããããã®æº¶æ¶²ã液ãšãããå¥ã«ã人è¡
æž ã¢ã«ããã³ïŒåçµä¹Ÿç¥åïŒ100mlã10mlã®
0.01Mãªã³é žç·©è¡æ¶²â0.15Mé£å¡©æ¶²æ··å液ïŒpHïŒ
7.4ïŒã«æº¶è§£ããããã®æº¶æ¶²ã液ãšãããæ°·å·
äžã«æ¶²ã®1.0mlã液ã«å ããåã枩床ã§çŽ30
åéæªæåå¿ããããæŽã«åå¿æ¶²ã«ãæ°ŽçŽ åããŠ
çŽ ãããªãŠã ïŒmgãå ããçŽïŒæéïŒãïŒâã§æª
æããªããéå ãè¡ãªã€ãã åå¿çµäºåŸãåžžæ³ã«ãããæªåå¿è©Šè¬çãé€ã
ãããéåžžã®éæããŠãŒãäžã«å ¥ãã24æééæ
ããéæŸå°æ§ãã€ãªã€ãå«ã溶液ãåŸãåŸãçŽã¡
ã«ã溶液ãååŸ0.22ÎŒmã®ãã€ã«ã¿ãŒãéããŠ1.0
mlãã€ããã€ã¢ã«ã«å å¡«ããåçµä¹Ÿç¥ããããšã«
ãããç®çãšããéæŸå°æ§çµæç©ãåŸãã以äžã®
æäœã¯å šãŠç¡èçã«ãããªã€ãã æ¬å®æœäŸã«ããåŸãããéæŸå°æ§çµæç©ã¯ãæ°Ž
ãå ããŠæº¶è§£ãããšããããèãæ·¡é»è²ã®æŸæãª
液ãäžããã å®æœäŸ ïŒ ïŒâïŒïœâã¢ããã¡ãã¬ã³ïŒããšãã«ãããã³
âïŒïŒïŒâãžãªã³âãã¹ïŒïŒâã¡ãã«ããªã»ãã«
ã«ããŸã³ïŒããŠããããŒãŒã«çµåãããéæŸå°æ§
ãã€ãªã€ãå«ãéæŸå°æ§çµæç© æ°·æµŽäžã粟補ãŠããããŒãŒïŒåçµä¹Ÿç¥åïŒ50mg
ãïŒmlã®æ°Žã«æº¶è§£ããããã®æº¶æ¶²ã液ãšããã
å¥ã«ïŒâïŒïœâã¢ããã¡ãã¬ã³ïŒããšãã«ããã
ã³âïŒïŒïŒâãžãªã³âãã¹ïŒïŒâã¡ãã«ããªã»ã
ã«ã«ããŸã³ïŒãïŒmgïŒmlã«ãªãããã«ãžã¡ãã«ã
ã«ã ã¢ããã«æº¶è§£ãããã®æº¶æ¶²ãã0.5mlãåãã
液ã«å ãããã€ãã§0.1Nå¡©é žæº¶æ¶²ã§pHãçŽ4.6
ã«èª¿æŽããããã®æ¶²ã液ãšãããæŽã«ã50mgïŒ
mlã®æ¿åºŠã®ïŒâã·ã¯ãããã·ã«âïŒâïŒïŒâã¢ã«
ããªãã«âïŒâãšãã«ïŒã«ã«ããžã€ãã氎溶液
1.5mlã液ã«å ããåŸã0.1Nå¡©é žæº¶æ¶²ã§åã³pH
ã4.6ã«èª¿æŽããïŒâ以äžã®æž©åºŠã§çŽïŒæéæªæ
ããã åå¿çµäºåŸãæªåå¿è©Šè¬çãè±å¡©çã«é€ãã
ãã溶åºå€ãšããŠ0.01Mãªã³é žç·©è¡æ¶²â0.15Mé£
塩液混å液ïŒpHïŒ7.4ïŒãçšããåå¿æº¶æ¶²ãã»ã
ã¢ããã¹ã¯ïŒ§â50ïŒïŒÃ30cmã«ã©ã ïŒã«ãããåŸã
ãŠããããŒãŒã«ã€ããŠã5.0mgïŒmlã«ãªãããã«ã
0.01Mãªã³é žç·©è¡æ¶²â0.15Mé£å¡©æ··å液ãçšãåž
éãã次ã«ååŸ0.22ÎŒmã®ãã€ã«ã¿ãŒãéããŠ1.5
mlãã€ããã€ã¢ã«ã«å å¡«ããç®çãšããéæŸå°æ§
çµæç©ãåŸãã以äžã®æäœã¯å šãŠç¡èçã«ãããª
ã€ãã æ¬å®æœäŸã«ããåŸãããéæŸå°æ§çµæç©ã¯ãã
ãèãæ·¡é»è²ã®æŸæãªæ¶²ã§ããã å®æœäŸ ïŒ ãã¯ãããŠã â99mæšèã€ãæŸå°æ§èšºæå€ã®è£œ
é å®æœäŸïŒã®æ¹æ³ã«ãã€ãŠåŸãéæŸå°æ§çµæç©ã®
1.0mlããéãã¯ãããŠã é žãããªãŠã ã®åœ¢ã§ã
ã¯ãããŠã â99mã3mCiãå«ãççé£å¡©æ°Žæº¶æ¶²
0.5mlãšæ··åããããæªæããããšã«ããããã¯
ãããŠã â99mæšèã€ãæŸå°æ§èšºæå€ãåŸãã æ¬å®æœäŸã§åŸããããã¯ãããŠã â99mæšèã€
ãæŸå°æ§èšºæå€ã¯ãããèãæ·¡é»è²ã®æŸæãªæ¶²ã§
ãããpHã¯çŽ3.0ã§ããã å®æœäŸ ïŒ ã¬ãªãŠã â67æšèã€ãæŸå°æ§èšºæå€ã®è£œé å®æœäŸïŒã®æ¹æ³ã«ãã€ãŠè£œé ãããéæŸå°æ§çµ
æç©ã0.2Mé ¢é žç·©è¡æ¶²ïŒpHïŒ4.0ïŒ1.0mlã§å®å š
ã«æº¶è§£ãã次ãã§å¡©åã¬ãªãŠã ãšããŠãã¬ãªãŠã
â67ã2mciãå«æãã0.01Nå¡©é žæº¶æ¶²0.5mlãå
ããŠãã¬ãªãŠã â67æšèã€ãæŸå°æ§èšºæå€ãåŸ
ãã æ¬å®æœäŸã§åŸãããã¬ãªãŠã â67æšèã€ãæŸå°
æ§èšºæå€ã¯ãããèãæ·¡é»è²ã®æŸæãªæ¶²ã§ããã
pHã¯çŽ3.7ã§ããã å®æœäŸ ïŒ ãã¯ãããŠã â99mæšèã€ãæŸå°æ§èšºæå€ã®æ§
質 å®æœäŸïŒã®æ¹æ³ã§è£œé ããããã¯ãããŠã â
99mæšèã€ãæŸå°æ§èšºæå€ã®æšèçã調ã¹ãã
ããã·ãªã«ã²ã«ãä¿æå±€ãšããã¡ãã«ãšãã«ã±ã
ã³ãå±é溶åªãšããèå±€ã¯ãããã°ã©ãã€ãŒãã
ããªããã©ãžãªã¯ãããã¹ãã€ããŒã§èµ°æ»ããã
æŸå°èœã¯åç¹ã«åäžãªããŒã¯ãšããŠæåºãããé
é¢ã®éã¹ã¯ãããŠã é žã€ãªã³ã«çžåœããæŸå°èœã
ãŒã¯ïŒRfïŒ1.0ïŒãªã©æŸå°æ§å€Ÿéç©ã®ååšãèªã
ãªãã€ãã 次ãã§ãããããŒã«ç·©è¡æ¶²ïŒpHïŒ8.6ïŒãå±é
液ãšããã»ã«ããŒã¹ã¢ã»ããŒããæ³³åèãšããé»
æ°æ³³åïŒ1.7mAïŒcmã15åïŒããããªã€ãåŸãã©
ãžãªã¯ãããã¹ãã€ããŒã§èµ°æ»ãããæŸå°èœã®äœ
眮ã¯ãåç·ããæ£åŽã«1.8cmã®å Žæã«åäžããŒã¯
ãšããŠèªãããã€ããã®æŸå°èœããŒã¯ã®äœçœ®ã¯ã
ãã³ãœãŒ3Rã«ãã人è¡æž ã¢ã«ããã³ã®çºè²ãã³
ããšäžèŽããã äžèšã®çµæãããæ¬çºæã®æ¹æ³ã§è£œé ãããã
ã¯ãããŠã â99mæšèã€ãæŸå°æ§èšºæå€ã®æšèç
ã¯ãã»ãŒ100ïŒ ã§ããããã€ããã®é»è·ç¶æ ã«ã€
ããŠã人è¡æž ã¢ã«ããã³ãšå·®ç°ãèªããªã€ãã å®æœäŸ ïŒ ãã¯ãããŠã â99mæšèã€ãæŸå°æ§èšºæå€ã®å
ç©äœå ååž å®æœäŸïŒã®æ¹æ³ã§è£œé ããããã¯ãããŠã â
99mæšèã€ãæŸå°èšºæå€ã®åã 0.1mlãã€ããšãã
è€æ°ã®S.D.ç³»éã©ããã®å°Ÿéèã«æäžããè¡äžæ¿
床ã®çµæå€åã調ã¹ããå¯Ÿç §ãšããŠåŸæ¥ã®æ¹æ³ã§
ãã¯ãããŠã â99mãçŽæ¥æšèãããã¯ãããŠã
â99mæšè人è¡æž ã¢ã«ããã³ããã³ãšãŒããŒ131
ã§æšèãããšãŒããŒ131æšè人è¡æž ã¢ã«ããã³ã«
ã€ããŠãåæ§ã®è©Šéšããããªãæ¯èŒãããè¡äžæ¿
床ã®çµ¶å¯Ÿå€ïŒïŒ æäžéïŒïœïŒå¹³åå€ïŒã®æšç§»ãã
ããã¯ããŠã â99mã§çŽæ¥æšèãããã¯ããã ãŠ
â99mæšè人å€æž ã¢ã«ããã³ããã³ãšãŒããŒ131
æšè人è¡æž ã¢ã«ããã³ãšå ±ã«æ¬¡è¡šã«ç€ºãã
ãè¡šã
ãè¡šã
æ¬å®æœäŸã«ããæãããªããã«ãæ¬çºæã®ãã¯
ãããŠã â99mæšèã€ãæŸå°æ§èšºæå€ã¯ãåŸæ¥ã®
æ¹æ³ã«ããçŽæ¥çã«æšèããŠåŸããããã¯ãããŠ
ã â99mæšè人è¡æž ã¢ã«ããã³ããã³ãšãŒããŒ
131æšè人è¡æž ã¢ã«ããã³ã«èŒã¹ãŠãé·æéã«ã
ãã€ãŠæ¥µããŠé«ãè¡äžæ¿åºŠãç¶æãããããšãæ
ãããšãªã€ããæ¬çºæã®ãã¯ãããŠã â99mæšè
ã€ãæŸå°æ§èšºæå€ã®é«ãäœå å®å®æ§ãç §æããã
è¡æ¶²åŸªç°ç³»ã®æåºãåæ æ€æ»ããã³å®éç枬å®æ³
ãç®çãšããæ žå»åŠèšºæã®çšéã«æ¥µããŠé©ããã
ã®ã§ããããšã瀺ãããã å®æœäŸ ïŒ ã¬ãªãŠã â67æšèã€ãæŸå°æ§èšºæå€ã®æ§è³ª å®æœäŸïŒã®æ¹æ³ã§è£œé ãããã¬ãªãŠã â67æšè
ã€ãæŸå°æ§èšºæå€ã®æšèçã調ã¹ããããããã
ãŒã«ç·©è¡æ¶²ïŒpHïŒ8.6ïŒãå±é液ãšããã»ã«ããŒ
ã¹ã¢ã»ããŒããæ³³åèãšããé»æ°æ³³åïŒ1.7mAïŒ
cmã15åïŒããããªã€ãåŸãã©ãžãªã¯ããããã€
ããŒã§èµ°æ»ãããæŸå°èœã®äœçœ®ã¯ãåç·ããæ£åŽ
ã«1.8cmã®å Žæã«åäžããŒã¯ãšããŠçŸããããã€
ãã®æŸå°èœããŒã¯ã®äœçœ®ã¯ããã³ãœãŒ3Rã«ãã
人è¡æž ã¢ã«ããã³ã®çºè²ãã³ããšäžèŽããã äžèšã®çµæãããæ¬çºæã®æ¹æ³ã§è£œé ãããã¬
ãªãŠã â67æšèã€ãæŸå°æ§èšºæå€ã®æšèçã¯ãã»
ãŒ100ïŒ ã§ããããã€ãã®é»è·çç¶æ ã«ã€ããŠãã
人è¡æž ã¢ã«ããã³ãšå·®ç°ãå¿ããªãã€ãã å®æœäŸ ïŒ ãŠããããŒãŒãçç掻æ§ç©è³ªãšããŠäœ¿çšããé
æŸå°æ§çµæç©ã®æ§è³ª å®æœäŸïŒã®æ¹æ³ã§è£œé ãããéæŸå°æ§çµæç©ã®
é µçŽ æŽ»æ§ããâαâã¢ã»ãã«ââãªãžã³ã¡ã
ã«ãšã¹ãã«ãçšãããšã¹ãã«å解æ³ã§æž¬å®ããçµ
æãåºçºç©è³ªã§ãã粟補ãŠããããŒãŒã®é µçŽ 掻æ§
ãšã»ãŒåãã§ãã€ãã äžèšã®çµæãããæ¬çºæã®æ¹æ³ã§è£œé ãããé
æŸå°æ§ãã€ãªã€ã®çç掻æ§ã¯å šãæãªãããŠããª
ãããšã確èªãããããŸãããã®éæŸå°æ§ãã€ãª
ã€ãã€ã³ãžãŠã â111ãã¬ãªãŠã 67ã§æšèããŠã
åæ§ã®é µçŽ 掻æ§ã¯ä¿ãããŠãããæ¬çºæã®æŸå°æ§
蚺æå€ã®çäœå æåã¯åºçºç©è³ªã§ãããŠããããŒ
ãŒãšå·®ç°ã¯ãªããã®ãšèããããã å®æœäŸ 10 éæŸå°æ§çµæç©ã®å®å®æ§ïŒãã®ïŒïŒ å®æœäŸïŒã®æ¹æ³ã§è£œé ãããéæŸå°æ§çµæç©
ããå·èµåº«ïŒïŒãïŒâïŒäžã§30æ¥éä¿åããåŸã
å®æœäŸïŒã®æ¹æ³ã«ãããã¯ãããŠã â99mæšèã€
ãæŸå°æ§èšºæå€ãšããããã«ã€ããŠãå®æœäŸïŒã®
æ¹æ³ã«ããèå±€ã¯ãããã°ã©ãã€ãŒããã³é»æ°æ³³
åãå®æœããæŽã«å®æœäŸïŒã®æ¹æ³ã«ããã©ããã«
ãããäœå æåã調ã¹ãã ãããã®å Žåãã補é çŽåŸã®éæŸå°æ§çµæç©ã
çšããŠãããªã€ãå®éšã®çµæãšåæ§ã®çµæãåŸã
ãã補é çŽåŸããã³30ééä¿ååŸã®éæŸå°æ§çµæ
ç©ã®éã«å·®ãèªããªã€ãã å®æœäŸ 11 éæŸå°æ§çµæç©ã®å®å®æ§ïŒãã®ïŒïŒ å®æœäŸïŒã®æ¹æ³ã§è£œé ãããéæŸå°æ§çµæç©
ããå·èµåº«ïŒïŒãïŒâïŒäžã§30æ¥éä¿åããåŸã
å®æœäŸïŒã®æ¹æ³ã«ããã¬ãªãŠã â67æšèã€ãæŸå°
æ§èšºæå€ãšããããã«ã€ããŠãå®æœäŸïŒã®æ¹æ³ã«
ããé»æ°æ³³åãå®æœãããé»æ°æ³³åã®çµæã¯ãå
äžãªæŸå°èœããŒã¯ãšããŠçŸããããã³ãœãŒ3Rã«
ããçºè²ã¯ã人è¡æž ã¢ã«ããã³ã®çºè²ãšäžèŽãã
補é çŽåŸããã³30æ¥éä¿ååŸã®éæŸå°æ§çµæç©ã®
éã«å·®ãèªããªãã€ãã å®æœäŸ 12 ãã¯ãããŠã â99mæšèã€ãæŸå°æ§èšºæã®å®å®
æ§ å®æœäŸïŒã®æ¹æ³ã§è£œé ãããã¯ãããŠã â99m
æšèã€ãæŸå°æ§èšºæå€ãåžžæž©ïŒ24ã27âïŒã§36æ
éä¿åããåŸãå®æœäŸïŒã®æ¹æ³ã«ããèå±€ã¯ãã
ãã°ã©ãã€ãŒããã³é»æ°æ³³åãå®æœããæŽã«å®æœ
äŸïŒã®æ¹æ³ã«ããã©ããã«ãããäœå æåã調ã¹
ãã ãããã®å Žåã補é çŽåŸã®ãã¯ãããŠã â99m
æšèã€ãæŸå°æ§èšºæå€ã«ã€ããŠåŸãããçµæãšå
æ§ã®çµæãåŸããã補é çŽåŸããã³36æéä¿ååŸ
ã®ãã¯ãããŠã â99mæšèã€ãæŸå°æ§èšºæå€ã®é
ã«å·®ç°ãèªããªã€ãã å®æœäŸ 13 ã¬ãªãŠã â67æšèã€ãæŸå°æ§èšºæå€ã®å®å®æ§ å®æœäŸïŒã®æ¹æ³ã§è£œé ãããã¬ãªãŠã â67æšè
ã€ãæŸå°æ§èšºæå€ãåžžæž©ïŒ24ã27âïŒã§ïŒæ¥éä¿
åããåŸãå®æœäŸïŒã®æ¹æ³ã«ããé»æ°æ³³åãå®æœ
ãããé»æ°æ³³åã®çµæã¯åäžãªæŸå°èœããŒã¯ãšã
ãŠçŸããããã³ãœãŒ3Rã«ããçºè²ã¯ã人è¡æž ã¢
ã«ããã³ãã®ãã®ã®çºè²ãšäžèŽãã補é çŽåŸãã
ã³ïŒæ¥éä¿ååŸã®ã¬ãªãŠã â67æšèã€ãæŸå°æ§èšº
æå€ã®éã«å·®ãèªããªã€ãã å®æœäŸ 14 éæŸå°æ§çµæç©ã®æ¯æ§ å®æœäŸïŒãïŒã«ç€ºããæ¹æ³ã«ããåŸãããéæŸ
å°æ§çµæç©ïŒå®æœäŸïŒã«ããéæŸå°æ§çµæç©ã«ã€
ããŠã¯ã0.2Mé ¢é žç·©è¡æ¶²ã«ããå®å šã«æº¶è§£ãã
ãã®ã䜿çšïŒããS.D.ç³»ééã©ããåïŒå¹ã®å矀
ã«å¯Ÿããäœé100ïœãããïŒmlãïŒäºå®ããŠãã
人äœæäžéã®600åã«çžåœïŒããŸãICRç³»ééããŠ
ã¹åïŒå¹ã®å矀ã«å¯Ÿãäœé10gããã0.5mlïŒäºå®
ããŠãã人äœæäžéã®3000åïŒããããããéè
å æäžãããå¥ã«å¯Ÿç §çŸ€ãšãŠåæ°ã®ååç©çŸ€ã«å¯Ÿ
ããŠãå容éã®ççé£å¡©æ°Žãéèå æäžããã以
äžã®ååç©10æ¥é飌è²ããæ¯æ¥äœéå€åãèšé²ã
ããäœéå€åã«ãããŠãéæŸå°æ§çµæç©ãæäžã
ã矀ãšå¯Ÿç §çŸ€ã®éã«ã¯ææã®å·®ã¯å¿ããããªã€
ãã10æ¥éã®é£Œè²èŠ³å¯ã®åŸããã¹ãŠã®åç©ã解å
ããåèåšã«ã€ããŠç°åžžã®æç¡ã芳å¯ããããç°
åžžãå¿ããåç©ã¯ãªãã€ããããªãã¡ãæ¬çºæã®
補å€ã¯äºå®ããŠãã人äœæäžéã®600ãªãã3000
åãïŒçš®ã®å®éšåç©ã«æäžããå Žåã«ãããŠãå š
ãç°åžžã¯å¿ããããªã€ãã å®æœäŸ 15 ãã¯ãããŠã â99mæšèã€ãæŸå°æ§èšºæå€ã®æ¯
æ§ å®æœäŸïŒã«ç€ºããæ¹æ³ã«ããåŸããããã¯ãã
ãŠã â99mæšèã€ãæŸå°æ§èšºæå€ããæŸå°èœãé©
床ã«æžè¡°ãããåŸãå®æœäŸ14ãšåæ§ã®æ¹æ³ã«ãã
è©Šéšããããªããšãããã¯ãããŠã â99mæšèã€
ãæŸå°æ§èšºæå€ãæäžãã矀ãšå¯Ÿç §çŸ€ã®éã«ã¯æ
æã®å·®ã¯å¿ããããªãã€ãã10æ¥éã®é£Œè²èŠ³å¯ã®
åŸããã¹ãŠã®åç©ã解åããåèåšã«ã€ããŠç°åžž
ã®æç¡ã芳å¯ããããç°åžžãèªããåç©ã¯ãªãã€
ããããªãã¡ãæ¬çºæã®è£œå€ã¯äºå®ããŠãã人äœ
æäžéã®400ãªãã2000åãïŒçš®ã®å®éšåç©ã«æ
äžããå Žåã«ãããŠãå šãç°åžžã¯èªããããªã€
ãã 以äžã®å®æœäŸã瀺ããŠæ¬çºæã説æãããã
ããåœæ¥è ã¯ããããã®å®æœäŸããæ¬çºæãäŸç€º
ããããã«æå³ããããã®ã§ããããã®ç¯å²ããª
ããå¶éããã®ã§ã¯ãªãããšãç解ãã¹ãã§ã
ãã
ãããŠã â99mæšèã€ãæŸå°æ§èšºæå€ã¯ãåŸæ¥ã®
æ¹æ³ã«ããçŽæ¥çã«æšèããŠåŸããããã¯ãããŠ
ã â99mæšè人è¡æž ã¢ã«ããã³ããã³ãšãŒããŒ
131æšè人è¡æž ã¢ã«ããã³ã«èŒã¹ãŠãé·æéã«ã
ãã€ãŠæ¥µããŠé«ãè¡äžæ¿åºŠãç¶æãããããšãæ
ãããšãªã€ããæ¬çºæã®ãã¯ãããŠã â99mæšè
ã€ãæŸå°æ§èšºæå€ã®é«ãäœå å®å®æ§ãç §æããã
è¡æ¶²åŸªç°ç³»ã®æåºãåæ æ€æ»ããã³å®éç枬å®æ³
ãç®çãšããæ žå»åŠèšºæã®çšéã«æ¥µããŠé©ããã
ã®ã§ããããšã瀺ãããã å®æœäŸ ïŒ ã¬ãªãŠã â67æšèã€ãæŸå°æ§èšºæå€ã®æ§è³ª å®æœäŸïŒã®æ¹æ³ã§è£œé ãããã¬ãªãŠã â67æšè
ã€ãæŸå°æ§èšºæå€ã®æšèçã調ã¹ããããããã
ãŒã«ç·©è¡æ¶²ïŒpHïŒ8.6ïŒãå±é液ãšããã»ã«ããŒ
ã¹ã¢ã»ããŒããæ³³åèãšããé»æ°æ³³åïŒ1.7mAïŒ
cmã15åïŒããããªã€ãåŸãã©ãžãªã¯ããããã€
ããŒã§èµ°æ»ãããæŸå°èœã®äœçœ®ã¯ãåç·ããæ£åŽ
ã«1.8cmã®å Žæã«åäžããŒã¯ãšããŠçŸããããã€
ãã®æŸå°èœããŒã¯ã®äœçœ®ã¯ããã³ãœãŒ3Rã«ãã
人è¡æž ã¢ã«ããã³ã®çºè²ãã³ããšäžèŽããã äžèšã®çµæãããæ¬çºæã®æ¹æ³ã§è£œé ãããã¬
ãªãŠã â67æšèã€ãæŸå°æ§èšºæå€ã®æšèçã¯ãã»
ãŒ100ïŒ ã§ããããã€ãã®é»è·çç¶æ ã«ã€ããŠãã
人è¡æž ã¢ã«ããã³ãšå·®ç°ãå¿ããªãã€ãã å®æœäŸ ïŒ ãŠããããŒãŒãçç掻æ§ç©è³ªãšããŠäœ¿çšããé
æŸå°æ§çµæç©ã®æ§è³ª å®æœäŸïŒã®æ¹æ³ã§è£œé ãããéæŸå°æ§çµæç©ã®
é µçŽ æŽ»æ§ããâαâã¢ã»ãã«ââãªãžã³ã¡ã
ã«ãšã¹ãã«ãçšãããšã¹ãã«å解æ³ã§æž¬å®ããçµ
æãåºçºç©è³ªã§ãã粟補ãŠããããŒãŒã®é µçŽ 掻æ§
ãšã»ãŒåãã§ãã€ãã äžèšã®çµæãããæ¬çºæã®æ¹æ³ã§è£œé ãããé
æŸå°æ§ãã€ãªã€ã®çç掻æ§ã¯å šãæãªãããŠããª
ãããšã確èªãããããŸãããã®éæŸå°æ§ãã€ãª
ã€ãã€ã³ãžãŠã â111ãã¬ãªãŠã 67ã§æšèããŠã
åæ§ã®é µçŽ 掻æ§ã¯ä¿ãããŠãããæ¬çºæã®æŸå°æ§
蚺æå€ã®çäœå æåã¯åºçºç©è³ªã§ãããŠããããŒ
ãŒãšå·®ç°ã¯ãªããã®ãšèããããã å®æœäŸ 10 éæŸå°æ§çµæç©ã®å®å®æ§ïŒãã®ïŒïŒ å®æœäŸïŒã®æ¹æ³ã§è£œé ãããéæŸå°æ§çµæç©
ããå·èµåº«ïŒïŒãïŒâïŒäžã§30æ¥éä¿åããåŸã
å®æœäŸïŒã®æ¹æ³ã«ãããã¯ãããŠã â99mæšèã€
ãæŸå°æ§èšºæå€ãšããããã«ã€ããŠãå®æœäŸïŒã®
æ¹æ³ã«ããèå±€ã¯ãããã°ã©ãã€ãŒããã³é»æ°æ³³
åãå®æœããæŽã«å®æœäŸïŒã®æ¹æ³ã«ããã©ããã«
ãããäœå æåã調ã¹ãã ãããã®å Žåãã補é çŽåŸã®éæŸå°æ§çµæç©ã
çšããŠãããªã€ãå®éšã®çµæãšåæ§ã®çµæãåŸã
ãã補é çŽåŸããã³30ééä¿ååŸã®éæŸå°æ§çµæ
ç©ã®éã«å·®ãèªããªã€ãã å®æœäŸ 11 éæŸå°æ§çµæç©ã®å®å®æ§ïŒãã®ïŒïŒ å®æœäŸïŒã®æ¹æ³ã§è£œé ãããéæŸå°æ§çµæç©
ããå·èµåº«ïŒïŒãïŒâïŒäžã§30æ¥éä¿åããåŸã
å®æœäŸïŒã®æ¹æ³ã«ããã¬ãªãŠã â67æšèã€ãæŸå°
æ§èšºæå€ãšããããã«ã€ããŠãå®æœäŸïŒã®æ¹æ³ã«
ããé»æ°æ³³åãå®æœãããé»æ°æ³³åã®çµæã¯ãå
äžãªæŸå°èœããŒã¯ãšããŠçŸããããã³ãœãŒ3Rã«
ããçºè²ã¯ã人è¡æž ã¢ã«ããã³ã®çºè²ãšäžèŽãã
補é çŽåŸããã³30æ¥éä¿ååŸã®éæŸå°æ§çµæç©ã®
éã«å·®ãèªããªãã€ãã å®æœäŸ 12 ãã¯ãããŠã â99mæšèã€ãæŸå°æ§èšºæã®å®å®
æ§ å®æœäŸïŒã®æ¹æ³ã§è£œé ãããã¯ãããŠã â99m
æšèã€ãæŸå°æ§èšºæå€ãåžžæž©ïŒ24ã27âïŒã§36æ
éä¿åããåŸãå®æœäŸïŒã®æ¹æ³ã«ããèå±€ã¯ãã
ãã°ã©ãã€ãŒããã³é»æ°æ³³åãå®æœããæŽã«å®æœ
äŸïŒã®æ¹æ³ã«ããã©ããã«ãããäœå æåã調ã¹
ãã ãããã®å Žåã補é çŽåŸã®ãã¯ãããŠã â99m
æšèã€ãæŸå°æ§èšºæå€ã«ã€ããŠåŸãããçµæãšå
æ§ã®çµæãåŸããã補é çŽåŸããã³36æéä¿ååŸ
ã®ãã¯ãããŠã â99mæšèã€ãæŸå°æ§èšºæå€ã®é
ã«å·®ç°ãèªããªã€ãã å®æœäŸ 13 ã¬ãªãŠã â67æšèã€ãæŸå°æ§èšºæå€ã®å®å®æ§ å®æœäŸïŒã®æ¹æ³ã§è£œé ãããã¬ãªãŠã â67æšè
ã€ãæŸå°æ§èšºæå€ãåžžæž©ïŒ24ã27âïŒã§ïŒæ¥éä¿
åããåŸãå®æœäŸïŒã®æ¹æ³ã«ããé»æ°æ³³åãå®æœ
ãããé»æ°æ³³åã®çµæã¯åäžãªæŸå°èœããŒã¯ãšã
ãŠçŸããããã³ãœãŒ3Rã«ããçºè²ã¯ã人è¡æž ã¢
ã«ããã³ãã®ãã®ã®çºè²ãšäžèŽãã補é çŽåŸãã
ã³ïŒæ¥éä¿ååŸã®ã¬ãªãŠã â67æšèã€ãæŸå°æ§èšº
æå€ã®éã«å·®ãèªããªã€ãã å®æœäŸ 14 éæŸå°æ§çµæç©ã®æ¯æ§ å®æœäŸïŒãïŒã«ç€ºããæ¹æ³ã«ããåŸãããéæŸ
å°æ§çµæç©ïŒå®æœäŸïŒã«ããéæŸå°æ§çµæç©ã«ã€
ããŠã¯ã0.2Mé ¢é žç·©è¡æ¶²ã«ããå®å šã«æº¶è§£ãã
ãã®ã䜿çšïŒããS.D.ç³»ééã©ããåïŒå¹ã®å矀
ã«å¯Ÿããäœé100ïœãããïŒmlãïŒäºå®ããŠãã
人äœæäžéã®600åã«çžåœïŒããŸãICRç³»ééããŠ
ã¹åïŒå¹ã®å矀ã«å¯Ÿãäœé10gããã0.5mlïŒäºå®
ããŠãã人äœæäžéã®3000åïŒããããããéè
å æäžãããå¥ã«å¯Ÿç §çŸ€ãšãŠåæ°ã®ååç©çŸ€ã«å¯Ÿ
ããŠãå容éã®ççé£å¡©æ°Žãéèå æäžããã以
äžã®ååç©10æ¥é飌è²ããæ¯æ¥äœéå€åãèšé²ã
ããäœéå€åã«ãããŠãéæŸå°æ§çµæç©ãæäžã
ã矀ãšå¯Ÿç §çŸ€ã®éã«ã¯ææã®å·®ã¯å¿ããããªã€
ãã10æ¥éã®é£Œè²èŠ³å¯ã®åŸããã¹ãŠã®åç©ã解å
ããåèåšã«ã€ããŠç°åžžã®æç¡ã芳å¯ããããç°
åžžãå¿ããåç©ã¯ãªãã€ããããªãã¡ãæ¬çºæã®
補å€ã¯äºå®ããŠãã人äœæäžéã®600ãªãã3000
åãïŒçš®ã®å®éšåç©ã«æäžããå Žåã«ãããŠãå š
ãç°åžžã¯å¿ããããªã€ãã å®æœäŸ 15 ãã¯ãããŠã â99mæšèã€ãæŸå°æ§èšºæå€ã®æ¯
æ§ å®æœäŸïŒã«ç€ºããæ¹æ³ã«ããåŸããããã¯ãã
ãŠã â99mæšèã€ãæŸå°æ§èšºæå€ããæŸå°èœãé©
床ã«æžè¡°ãããåŸãå®æœäŸ14ãšåæ§ã®æ¹æ³ã«ãã
è©Šéšããããªããšãããã¯ãããŠã â99mæšèã€
ãæŸå°æ§èšºæå€ãæäžãã矀ãšå¯Ÿç §çŸ€ã®éã«ã¯æ
æã®å·®ã¯å¿ããããªãã€ãã10æ¥éã®é£Œè²èŠ³å¯ã®
åŸããã¹ãŠã®åç©ã解åããåèåšã«ã€ããŠç°åžž
ã®æç¡ã芳å¯ããããç°åžžãèªããåç©ã¯ãªãã€
ããããªãã¡ãæ¬çºæã®è£œå€ã¯äºå®ããŠãã人äœ
æäžéã®400ãªãã2000åãïŒçš®ã®å®éšåç©ã«æ
äžããå Žåã«ãããŠãå šãç°åžžã¯èªããããªã€
ãã 以äžã®å®æœäŸã瀺ããŠæ¬çºæã説æãããã
ããåœæ¥è ã¯ããããã®å®æœäŸããæ¬çºæãäŸç€º
ããããã«æå³ããããã®ã§ããããã®ç¯å²ããª
ããå¶éããã®ã§ã¯ãªãããšãç解ãã¹ãã§ã
ãã
Claims (1)
- ãç¹èš±è«æ±ã®ç¯å²ã ïŒ åŒ ïŒåŒäžãã¯ççŽ æ°ïŒãïŒã®ã¢ã«ãã«åºãïœã¯
ïŒãïŒã®æŽæ°ãè¡šããïŒ ã§ç€ºãããããªã»ãã«ã«ããŸã³èªå°äœã«ãã®ã¢ã
ãåºïŒâNH2ïŒãä»ããŠçç掻æ§ååç©ãåå
çµåãããŠåœ¢æãããç©è³ªãããªãæŸå°æ§éå±æš
èçšæ äœã ïŒ çç掻æ§ååç©ãèçœãæçç©è³ªããã«ã¢
ã³ãç³ããã³èèªé žãªãã³ã«ãããã®èªå°äœãã
ãªã矀ããéžæããããã®ã§ãããç¹èš±è«æ±ã®ç¯
å²ç¬¬ïŒé èšèŒã®æŸå°æ§éå±æšèçšæ äœã ïŒ åŒ ïŒåŒäžãã¯ççŽ ïŒãïŒã®ã¢ã«ãã«åºãïœã¯ïŒ
ãïŒã®æŽæ°ãè¡šããïŒ ã§ç€ºãããããªã»ãã«ã«ããŸã³èªå°äœã«ãã®ã¢ã
ãåºïŒâNH2ïŒãä»ããŠçç掻æ§ååç©ãååŠ
çµåãããŠåœ¢æãããç©è³ªãããªãæŸå°æ§éå±æš
èçšæ äœãšãæŸå°æ§éå±ãåœè©²æ äœãšãã¬ãŒãçµ
åå¯èœãªåå䟡ç¶æ ã«éå ããããšãã§ããéã®
éå å€ãå«æããŠãªããæŸå°æ§éå±æšèçšæ äœçµ
æç©ã ïŒ éå å€ã第ïŒã¹ãºå¡©ã§ãããç¹èš±è«æ±ã®ç¯å²
第ïŒé èšèŒã®æŸå°æ§éå±æšèçšæ äœçµæç©ã ïŒ åŒ ïŒåŒäžãã¯ççŽ æ°ïŒãïŒã®ã¢ã«ãã«åºãïœã¯
ïŒãïŒã®æŽæ°ãè¡šããïŒ ã§ç€ºãããããªã»ãã«ã«ããŸã³èªå°äœã«ãã®ã¢ã
ãåºïŒâNH2ïŒãä»ããŠçç掻æ§ååç©ãååŠ
çµåãããŠåœ¢æãããç©è³ªãããªãæŸå°æ§éå±æš
èçšæ äœã«ãæŸå°æ§éå±ãæ æãããŠãªããæŸå°
æ§èšºæå€ã ïŒ æŸå°æ§éå±ããã¯ãããŠã ã§ãããç¹èš±è«æ±
ã®ç¯å²ç¬¬ïŒé èšèŒã®æŸå°æ§èšºæå€ã ïŒ ãã¯ãããŠã ãéãã¯ãããŠã é žã€ãªã³ã§ã
ããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®æŸå°æ§èšºæå€ã
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57155628A JPS5944329A (ja) | 1982-09-07 | 1982-09-07 | æ°èŠãªæŸå°æ§èšºæå€ |
| US06/438,776 US4511550A (en) | 1982-09-07 | 1982-11-03 | 1-(p-Substituted or unsubstituted aminoalkyl)phenylpropane-1,2-dione bis(thiosemicarbazone) derivatives, and their production and use |
| AU90235/82A AU533722B1 (en) | 1982-09-07 | 1982-11-08 | Phenylpropane-1,2-dione bis(thio-semicarbazone) derivatives |
| CA000416231A CA1219592A (en) | 1982-09-07 | 1982-11-24 | 1-(p-substituted or unsubstituted aminoalkyl) phenyl- propane-1,2-dione bis(thiosemicarbazone) derivatives, and their production and use |
| KR8205481A KR860001360B1 (ko) | 1982-09-07 | 1982-12-07 | 1-(p-ì¹í ëë ë¹ì¹í ìë¯žë žìí¬) íëíë¡í-1, 2-ëìš ë¹ì€(í°ì€ìžë¯žì¹Žë¥Žë°ì¡Ž) ì ë첎ì ì ì¡°ë°©ë² |
| DE8282111698T DE3270316D1 (en) | 1982-09-07 | 1982-12-16 | 1-(p-substituted or unsubstituted aminoalkyl)phenylpropane-1,2-dione bis(thiosemicarbazone) derivatives, and their production and use |
| EP82111698A EP0103049B1 (en) | 1982-09-07 | 1982-12-16 | 1-(p-substituted or unsubstituted aminoalkyl)phenylpropane-1,2-dione bis(thiosemicarbazone) derivatives, and their production and use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57155628A JPS5944329A (ja) | 1982-09-07 | 1982-09-07 | æ°èŠãªæŸå°æ§èšºæå€ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5944329A JPS5944329A (ja) | 1984-03-12 |
| JPH0433767B2 true JPH0433767B2 (ja) | 1992-06-04 |
Family
ID=15610147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57155628A Granted JPS5944329A (ja) | 1982-09-07 | 1982-09-07 | æ°èŠãªæŸå°æ§èšºæå€ |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5944329A (ja) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5395327B2 (ja) | 2003-09-17 | 2014-01-22 | ããŒãã»ãªãã»ãªãŒãžãšã³ãïŒã¶ã»ãŠãããŒã·ãã€ã»ãªãã»ãããµã¹ã»ã·ã¹ãã | æ©æ§ããŒã¹ã®æšçåããèµèβ现èç»ååããã³æ²»ç |
-
1982
- 1982-09-07 JP JP57155628A patent/JPS5944329A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5944329A (ja) | 1984-03-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPH036124B2 (ja) | ||
| US5371184A (en) | Radiolabelled peptide compounds | |
| EP0345723B1 (en) | Diethylenetriamine pentaacetic acid derivatives | |
| KR860001565B1 (ko) | ë°©ì¬ì± ì§ëšì ì ì ì¡°ë°©ë² | |
| US4564472A (en) | 3-Aminomethylene-2,4-pentanedione bis(thiosemicarbazone) derivatives, and their production and use | |
| JP3074160B2 (ja) | æªæ§è «ççšç»ååå€ | |
| JPS641449B2 (ja) | ||
| US5250702A (en) | Diethylenetriamine pentaacetic acid derivatives | |
| EP3011976A1 (en) | 18F-tagged inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents | |
| JPS6058927A (ja) | æŸå°èœæšèè¡å°æ¿è£œå€ | |
| JP2000507233A (ja) | æ°èŠã®äžå è€åäœæŸå°æ§è¬å€ | |
| US5380513A (en) | Methods for reducing non-target retention of immunoconjugates and metabolites thereof | |
| JPH0433767B2 (ja) | ||
| US4559221A (en) | P-Glyoxyloylphenylalkanoic acid bis(thiosemicarbazone) derivatives, and their production and use | |
| JP4878119B2 (ja) | ãšãã³ããªããŒçŽç²ãªïŒïŒïŒ³ïŒïŒïŒ³ïŒâåã³ïŒïŒïŒ²ïŒïŒïŒ²ïŒâïŒâïœâããããã³ãžã«âïŒâã¡ãã«âïŒïŒïŒïŒïŒâããªã¢ã¶âïŒïŒ®ïŒïŒïŒ®ïŒïŒïŒ®âããªã«ã«ããã·ã¡ãã«âïŒïŒïŒïŒâãŠã³ãã«ã³äºé žåã³ãããã®èªå°äœããããã®è£œé æ¹æ³äžŠã³ã«å»è¬åã®è£œé ã®ããã®ãããã®äœ¿çš | |
| JPH0460974B2 (ja) | ||
| JP2564459B2 (ja) | æŸå°æ§å»è¬å調補çšãã£ãªã€ãŒ | |
| JP2677543B2 (ja) | çç掻æ§ç©è³ªçµåé«ååååç©ããã³åœè©²ååç©ãå«ãæŸå°æ§å»è¬å調補çšãã£ãªã¢ãŒ | |
| KR860001360B1 (ko) | 1-(p-ì¹í ëë ë¹ì¹í ìë¯žë žìí¬) íëíë¡í-1, 2-ëìš ë¹ì€(í°ì€ìžë¯žì¹Žë¥Žë°ì¡Ž) ì ë첎ì ì ì¡°ë°©ë² | |
| JPH0416465B2 (ja) | ||
| JPH0414084B2 (ja) | ||
| JP2677544B2 (ja) | æŸå°æ§éå±å çŽ çµåé«ååååç©ããã³åœè©²ååç©ãå«ãæŸå°æ§å»è¬å | |
| JPH047329B2 (ja) | ||
| JPH0759524B2 (ja) | æŸå°æ§å»è¬åãšãã®èª¿è£œçšé«ååååç© | |
| JPH08507528A (ja) | æŸå°ç·æ®åœ±ã€ã¡ãŒãžã³ã°å€ã«æçšãªã€ãããŸãŒã«åºéšãæããçªçŽ âç¡«é»é äœåé¡ |