JPH0371894B2 - - Google Patents

Info

Publication number
JPH0371894B2
JPH0371894B2 JP60066422A JP6642285A JPH0371894B2 JP H0371894 B2 JPH0371894 B2 JP H0371894B2 JP 60066422 A JP60066422 A JP 60066422A JP 6642285 A JP6642285 A JP 6642285A JP H0371894 B2 JPH0371894 B2 JP H0371894B2
Authority
JP
Japan
Prior art keywords
components
transporting
transport pipe
head
lumen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP60066422A
Other languages
English (en)
Other versions
JPS60225567A (ja
Inventor
Reedoru Haintsu
Habison Georugu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IMUNOO AG FUIA HIEEMITSUSHUUMEDEITSUIINITSUSHE PURODAKUTE
Original Assignee
IMUNOO AG FUIA HIEEMITSUSHUUMEDEITSUIINITSUSHE PURODAKUTE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3505786&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPH0371894(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by IMUNOO AG FUIA HIEEMITSUSHUUMEDEITSUIINITSUSHE PURODAKUTE filed Critical IMUNOO AG FUIA HIEEMITSUSHUUMEDEITSUIINITSUSHE PURODAKUTE
Publication of JPS60225567A publication Critical patent/JPS60225567A/ja
Publication of JPH0371894B2 publication Critical patent/JPH0371894B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491—Surgical glue applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00—Medical syringes, e.g. enemata; Irrigators
    • A61M3/005—Medical syringes, e.g. enemata; Irrigators comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491—Surgical glue applicators
    • A61B2017/00495—Surgical glue applicators for two-component glue

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Materials For Medical Uses (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Surgical Instruments (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Treatment Of Fiber Materials (AREA)
  • Nozzles (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Description

【発明の詳細な説明】 この発明は、創傷を密封し、出血を止めるなど
の目的で、ヒトまたは動物の組織または臓器各部
を結合させる手段として、縫合を行なわずに結合
するために、もしくは縫合を介助する手段として
適用されるヒトまたは動物のたんぱく質からなる
組織接着剤、特にたんぱく質溶液と血液凝固促進
因子溶液を混合することによつてその場（インサ
イチユ）で形成される組織接着剤、を適用するの
に用いる装置に関するものであつて、該装置は、
各適用成分を収容し、その先端が連結部となつて
いる複数個の容器（好ましくは標準的な、先端が
円錐状をなしている複数個のプラスチツク製使い
捨て注射器筒）と、各適用成分毎の別々の輸送管
を含んでいる、該容器にとり付け可能な連結ヘツ
ドからなることを特徴としている。
このような型の装置が、米国特許第4359049号
に既に記載されている。この場合、組織接着剤と
して、一方は第因子およびフイブリノーゲン
含有溶液、また他方にはトロンビン含有溶液が使
用される。これらの成分は、連結ヘツドにとり付
けられている配合針内で混合され、処置または保
護すべき創傷部位に適用される。
この既知装置は基本的に成功を収めてはいる
が、適用中に成分の流れを中断したり、長くて細
い配合針を使用した場合、組織接着剤が配合針の
中で凝固していまう生涯を生じることがある。し
たがつて、配合針はただちに交換しなければなら
ない。
このような処置は、特に適用部位が例えば体腔
内のように容易に到達し難い例では、外科適手術
の進行がかなり妨げられる結果を招来することと
なる。
米国特許第4359049号には、構成成分を混合い
て噴霧する噴霧構造と、混合すべき成分の細導管
に対してある角度をもつて配置さている滅菌ガス
の供給管からなる該装置の修飾態様が記載されて
いる。この噴霧装置を使用することにより、供給
管の開口部から10〜20cm離れた前方において各成
分の噴霧化が起こる。したがつて、この装置は広
い区域での使用にのみ適しており、手の届きにい
く手術分野では矢帳り使用できない。
最後に、凝固性物質を体腔内に適用するプラス
チツク製カテーテルからなる装置が、リンシーア
およびフアツイオ（Linscheer and Fazio）の論
文（ガストロエンテロロジー
（Gastroenterology）、77巻、642〜649頁、1979
年）により発表されるに至つた。この装置は混合
すべき成分毎の複数個の容器からなつており、各
容器は、１本の多筒式カテーテル内の各細導管と
分離できない形でかつながつているチユーブ導管
へ連結されている。然しながら、このような装置
の場合、前もつて作成できず、また内視鏡と組み
合わせて適用部位へ誘導されることによつてのみ
使用し得る種々の適用装置と連結したり、交換し
たりすることが全くできない不便さがある。
本発明はこれらの不便さと障害を排除すること
を目的とするものであつて、処置中に必要となる
ことがある混合すべき成分の流れの中断にも装置
の部品の交換を要さず、しかも故障なく、到達困
難な適用部位にも使用し得る、先に示したような
装置を設計することを目的としている。また、本
発明に示した装置は内視鏡を用い、または用いな
いいずれの場合にも使用できる。
これらの目的は、連結ヘツドに、各成分運搬用
輸送管と密着平行配置された医療用ガス運搬用の
油送管であつて、連結ヘツドの前端部へ通じてい
る輸送管を追加して設けていること、およびこの
連結ヘツドが医療用ガス輸送管を含む多筒式カテ
ーテルと連結し得ることを特徴とする装置により
達成される。
連結ヘツドは、多筒式カテーテルと継ぎ目なく
作られていてもよく、またはこの両者が、該カテ
ーテル内の各輸送管（管腔）と連結ヘツド内の輸
送管とが連絡する様に連結し得るものであつても
よい。
尚、カテーテルには、各成分運搬用輸送管（管
腔）と医療用ガス運搬用輸送管（管腔）以外に、
形状保持用ワイヤー用の管腔が追加して設けられ
ている。
以上に述べた本発明における装置によれば、医
療用ガスの圧を調節することによつて、カテーテ
ルの開口部の近傍または前方で各成分を微粒子化
（噴霧化）させることができ、従つて、該装置は
小範囲の適用部位にも使用することができる。
本発明による装置について、添付した図を引用
してその実施態様を例示し、更に詳細な説明を加
える。
標準的な２本の使い捨て注射器の筒は１および
２で示され、その一方はトロンビン含有溶液、他
の一方は第因子とフイブリノーゲンを含有す
る溶液を収容することにあてる。注射筒１，２は
標準化されたプラスチツク製使い捨て注射器をも
つて好適に充当できる。この２本の筒を共に１個
の支持体３に挿入する。この支持体はＵ字型をし
ている２本の円筒４，５からなつており、それぞ
れの先端にはつまみ６が作られているので、この
円筒の上方から挿入される注射筒１，２はきつち
りとはめこまれ、つまみ６で支持体に固定され
る。
支持体３の根元のところで、Ｕ字型の凹み９，
１０を有する握り（finger grip）８を、注射筒
の根元に突き出している該注射筒末端のフランジ
１１，１２へとり付けることによつて、注射筒は
その縦軸の方向１３に沿つてしつかりと固定され
る。支持体の握り部分８に開けられている穴１６
を突き抜け、Ｕ字型円筒４，５の間の空間部１６
へ向けて、ガイド棒１５が設けられている。該ガ
イド棒は２本の注射器の内筒（ピストン）２０，
２１の頭の部分（thum yokes）１８，１９を同
時に動かせる共通の可動体１７の結合されてい
る。然し、この２本の内筒がそれぞれ独立して動
かすこともできるのは言うまでもない。
２本の注射筒の円錐形の連結部２５，２６を連
結ヘツド２７のぴつたりあつた凹みに差し込むこ
とにより、これと連結する。成分運搬用輸送管２
８および２９が、各円錐形の連結部２５，２６か
ら連結ヘツドの前方部へそれぞれ連結ヘツドの中
を通つている。連結ヘツド内には、更にもう１本
医療用ガス運搬用輸送管３０が輸送管２８および
２９と密着してこれと平行に隣接し連結ヘツドの
前方部へ同様に通じている。
連結ヘツドは４本の管腔により仕切られた多管
腔カテーテル３１（第３図）と完全に１本につな
がつており、その１本の管腔は輸送管２８と、他
の１本は輸送管２９とつながり、３番目の管腔は
ガス運搬用輸送管３０とつながり、また、４番目
の管腔３２には形状保持用ワイヤー３３が挿入さ
れている。このワイヤーによつて、該カーテルを
適用部位まで移動させるべく、どのような所望の
形にも変形することが可能である あらかじめバルブを開いた後（ガス運搬用輸送
管３０を始動する−図面には示されていない）、
注射器内筒１８，１９または可動体１７を加圧す
ることにより混合すべき成分が適用部位へ供給さ
れるが、この間、カテーテルの開口部はガスを一
定に流すことによつて確実に正常に保たれる。
適用時における医療用ガスの流通速度および流
通量を適宜選択することによつて、開口部におい
て成分を液体の形で排出したりあるいは成分を噴
霧化することができ、こようにして装置を広範囲
に適用することができる。
【図面の簡単な説明】
第１図は本発明の装置の一部切断側面図、第２
図は本発明の装置の部分的断面図、第３図は、第
１図の−の線に沿つて切断したカテーテルの
断面図である。 １および２……容器、３……支持体、２７……
連結ヘツド、２８および２９……成分運搬用輸送
管、３０……医療用ガスの運搬用輸送管、３１…
…多管腔カテーテル。

Claims (1)

  1. 【特許請求の範囲】 １ 創傷を密封したり出血を止める目的で、ヒト
    または動物の組織または臓器部分を縫い目なく結
    合したり、もしくは縫合を介助する手段として適
    用されるヒトまたは動物のたんぱく質からなる組
    織接着剤であつて、たんぱく質溶液と血液凝固促
    進因子溶液からなる少なくとも２つの成分を混合
    することによつてその場で形成される組織接着
    剤、の適用に用いる装置であつて、 (1) 先端が連結部２５，２６となつている、上記
    の成分を別々に収容するのに適した複数個の容
    器１，２、および (2) 該容器の連結部にとり付け可能な連結ヘツド
    であつて、各成分用に別々に設けられた、容器
    の連結部２５，２６の開口部と連絡しており連
    結ヘツドの先端にまで達している成分運搬用輸
    送管２８，２９を含んでいる連結ヘツド２７、
    からなる手段であつて、該連結ヘツドは、成分
    運搬用輸送管に密着平行配置された、連結ヘツ
    ドの先端にまで達している医療用ガス運搬用輸
    送管３０を更に含んでいること、および該連結
    ヘツドは、成分運搬用輸送管および医療用ガス
    運搬用輸送管のそれぞれと連絡し得る管腔およ
    び形状保持用ワイヤーを収容するための管腔を
    含んでいる多管腔カテーテルであつて、その先
    端から各成分および医療用ガスが排出されるカ
    テーテル、に取り付け可能であることを特徴と
    する装置。 ２ 複数個の容器がプラスチツク製の標準化され
    た複数個の使い捨て注射器筒からなる特許請求の
    範囲第１項に記載の装置。
JP60066422A 1984-03-29 1985-03-28 組織接着剤の適用に用いる装置 Granted JPS60225567A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT1063/84 1984-03-29
AT0106384A AT379311B (de) 1984-03-29 1984-03-29 Vorrichtung zur applikation eines gewebeklebstoffes

Publications (2)

Publication Number Publication Date
JPS60225567A JPS60225567A (ja) 1985-11-09
JPH0371894B2 true JPH0371894B2 (ja) 1991-11-14

Family

ID=3505786

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60066422A Granted JPS60225567A (ja) 1984-03-29 1985-03-28 組織接着剤の適用に用いる装置

Country Status (8)

Country Link
US (1) US4631055A (ja)
EP (2) EP0156098B1 (ja)
JP (1) JPS60225567A (ja)
AT (3) AT379311B (ja)
CA (1) CA1225560A (ja)
DE (2) DE3485993D1 (ja)
DK (1) DK165485C (ja)
ES (1) ES541272A0 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08281150A (ja) * 1995-04-18 1996-10-29 Nissho Corp 生体組織接着剤スプレー用ノズル
JPH1176245A (ja) * 1997-09-09 1999-03-23 Nissho Corp 生体組織接着剤投与具

Families Citing this family (270)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT382783B (de) * 1985-06-20 1987-04-10 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes
JPS62271999A (ja) * 1986-03-03 1987-11-26 ビー　ビー　エイ　グループ　ピー．エル．シー． 粘性材料用空圧デイスペンサ−
JPH0630168Y2 (ja) * 1986-04-23 1994-08-17 ヘキストジャパン株式会社 生体組織接着剤用ノズル
AT388503B (de) * 1987-05-21 1989-07-25 Immuno Ag Set zur bereitstellung und applikation eines gewebeklebstoffes
EP0294672B1 (de) * 1987-06-10 1992-08-12 Wilhelm A. Keller Doppel-Austragkartusche für Zweikomponentenmassen
DE3725552A1 (de) * 1987-08-01 1989-02-09 Hoechst Ag Spruehkopf zum applizieren eines mehrkomponentenmaterials mittels gas
DE3725553A1 (de) * 1987-08-01 1989-02-09 Hoechst Ag Spruehkopf zum applizieren eines mehrkomponentenmaterials
US4978336A (en) * 1987-09-29 1990-12-18 Hemaedics, Inc. Biological syringe system
US4902281A (en) * 1988-08-16 1990-02-20 Corus Medical Corporation Fibrinogen dispensing kit
US5226877A (en) * 1989-06-23 1993-07-13 Epstein Gordon H Method and apparatus for preparing fibrinogen adhesive from whole blood
US5116315A (en) * 1989-10-03 1992-05-26 Hemaedics, Inc. Biological syringe system
US5104375A (en) * 1989-10-16 1992-04-14 Johnson & Johnson Medical, Inc. Locking holder for a pair of syringes and method of use
US4979942A (en) * 1989-10-16 1990-12-25 Johnson & Johnson Medical, Inc. Two component syringe delivery system
WO1991007197A1 (de) * 1989-11-21 1991-05-30 Andreas Lindner Injektionsvorrichtung
US5318524A (en) * 1990-01-03 1994-06-07 Cryolife, Inc. Fibrin sealant delivery kit
US5219328A (en) * 1990-01-03 1993-06-15 Cryolife, Inc. Fibrin sealant delivery method
US5644032A (en) * 1990-08-06 1997-07-01 Fibrin Corporation Process for producing fibrinogen concentrates
US5420250A (en) * 1990-08-06 1995-05-30 Fibrin Corporation Phase transfer process for producing native plasma protein concentrates
FR2668060B1 (fr) * 1990-10-17 1993-01-29 Fondation Nale Transfusion San Dispositif d'application d'un melange extemporane de plusieurs composants.
US6117425A (en) * 1990-11-27 2000-09-12 The American National Red Cross Supplemented and unsupplemented tissue sealants, method of their production and use
US7229959B1 (en) 1990-11-27 2007-06-12 The American National Red Cross Supplemented fibrin matrix delivery systems
US6197325B1 (en) * 1990-11-27 2001-03-06 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US6054122A (en) * 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US6559119B1 (en) 1990-11-27 2003-05-06 Loyola University Of Chicago Method of preparing a tissue sealant-treated biomedical material
US5286258A (en) * 1991-03-08 1994-02-15 Habley Medical Technology Corporation Multipharmaceutical delivery system
US5240146A (en) * 1990-12-14 1993-08-31 Smedley William H Variable proportion dispenser
US5211627A (en) * 1991-02-12 1993-05-18 C. R. Bard, Inc. Catheter and method for infusion of aerated liquid
US5298023A (en) * 1991-03-08 1994-03-29 Habley Medical Technology Corporation Multiple pharmaceutical dispenser with accumulator
US5368563A (en) * 1991-12-18 1994-11-29 Micromedics, Inc. Sprayer assembly for physiologic glue
US5423752A (en) * 1992-07-31 1995-06-13 Habley Medical Technology Corporation Variable proportion dispenser with cartridge replacement assembly
US5271527A (en) * 1992-04-02 1993-12-21 Habley Medical Technology Corporation Reusable pharmaceutical dispenser with full stroke indicator
US5253785A (en) * 1992-04-02 1993-10-19 Habley Medical Technology Corp. Variable proportion dispenser
DK0634140T4 (da) * 1992-09-26 2004-09-06 Chemo Sero Therapeut Res Inst Applikator til vævsadhæsiv
US5378233A (en) * 1992-11-18 1995-01-03 Habley Medical Technology Corporation Selected dose pharmaceutical dispenser
US5290259A (en) * 1993-02-18 1994-03-01 Ultradent Products, Inc. Double syringe delivery system
US5330974A (en) * 1993-03-01 1994-07-19 Fibratek, Inc. Therapeutic fibrinogen compositions
US5584815A (en) * 1993-04-02 1996-12-17 Eli Lilly And Company Multi-cartridge medication injection device
ZA941881B (en) * 1993-04-02 1995-09-18 Lilly Co Eli Manifold medication injection apparatus and method
US5951531A (en) * 1993-04-20 1999-09-14 Medchem Products, Inc. Apparatus and method for applying a particulate hemostatic agent to living tissue
AT400675B (de) * 1993-10-18 1996-02-26 Immuno Ag Spritzengarnitur zur aufbewahrung und applikation eines mehrkomponentenmaterials, spritzenvorrichtung und betätigungseinrichtung hiefür sowie verfahren zum herstellen einer befüllten, sterilen spritzenvorrichtung
AT400304B (de) * 1994-02-28 1995-12-27 Immuno Ag Vorrichtung zur applikation eines mehrkomponenten-gewebeklebstoffes
US5474540A (en) * 1994-03-25 1995-12-12 Micromedics, Inc. Fluid separation control attachment for physiologic glue applicator
US5725499A (en) * 1994-05-11 1998-03-10 Plas-Pak Industries, Inc. Dual barreled syringe and methods of assembly and use
AT421U1 (de) * 1994-07-05 1995-10-25 Immuno Ag Adapterhuelse und katheter-set mit einer solchen adapterhuelse
US5605541A (en) 1994-12-07 1997-02-25 E. R. Squibb And Sons, Inc. Fibrin sealant applicatoor
US5585007A (en) 1994-12-07 1996-12-17 Plasmaseal Corporation Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant
US20020131933A1 (en) * 1996-01-16 2002-09-19 Yves Delmotte Biopolymer membrane and methods for its preparation
JPH11502431A (ja) * 1995-01-16 1999-03-02 バクスター インターナショナル インコーポレイテッド 手術後の癒着を防止するための架橋化フィブリンの自己支持シート様材料
US5733545A (en) * 1995-03-03 1998-03-31 Quantic Biomedical Partners Platelet glue wound sealant
EP0738498A1 (en) * 1995-04-18 1996-10-23 Machida Endoscope Co., Ltd Surgical adhesive sprayer
EP0957772A2 (en) * 1995-06-06 1999-11-24 Quantic Biomedical Partners Wound sealant preparation and application device and method
US5843793A (en) * 1995-10-16 1998-12-01 Johnson & Johnson Clinical Diagnostics, Inc. Container for staining of cells and tissues in combination with a roller and a support
ES2227624T3 (es) 1995-12-07 2005-04-01 Bristol-Myers Squibb Company Dispositivo para aplicar una mezcla de dos componentes liquidos.
US5814022A (en) 1996-02-06 1998-09-29 Plasmaseal Llc Method and apparatus for applying tissue sealant
US5759169A (en) 1996-03-13 1998-06-02 New York Blood Center Inc. Fibrin sealant glue-gun
DE19617369A1 (de) * 1996-04-30 1997-11-06 Immuno Ag Lagerstabile Fibrinogen-Präparate
WO2000062828A1 (en) 1996-04-30 2000-10-26 Medtronic, Inc. Autologous fibrin sealant and method for making the same
DE29723807U1 (de) * 1996-04-30 1999-11-04 Medtronic, Inc., Minneapolis, Minn. Autologe Fibrin-Blutstillungsmittel
AR013829A1 (es) 1996-07-12 2001-01-31 Baxter Int Un dispositivo medico para suministrar cantidades volumetricas de un primer y un segundo fluido, bioquimicamente reactivos, y metodo para suministrarfibrina a una superficie con dicho dispositivo
DE19636622C1 (de) * 1996-09-10 1998-06-10 Omrix Biopharm Sa Auftragvorrichtung zum Auftragen eines Mehrkomponenten-Gewebeklebstoffs und Halterung für eine solche Auftragvorrichtung
US8003705B2 (en) 1996-09-23 2011-08-23 Incept Llc Biocompatible hydrogels made with small molecule precursors
US20090324721A1 (en) 1996-09-23 2009-12-31 Jack Kennedy Hydrogels Suitable For Use In Polyp Removal
WO1998012274A1 (en) * 1996-09-23 1998-03-26 Chandrashekar Pathak Methods and devices for preparing protein concentrates
US5968018A (en) * 1996-10-30 1999-10-19 Cohesion Corporation Cell separation device and in-line orifice mixer system
ATE357946T1 (de) * 1996-11-15 2007-04-15 Bristol Myers Squibb Co Vorrichtung zur anwendung einer mischung von zwei oder mehreren flüssigen komponenten zur bildung eines biomaterials
US6613020B1 (en) 1996-12-06 2003-09-02 Bristol-Myers Squibb Company Method of applying a mixture of two liquid components as well as a device for carrying out the method
US6783514B2 (en) 1997-01-31 2004-08-31 United States Surgical Corporation Fibrin sealant applicator
DE19709896C1 (de) * 1997-03-11 1998-12-24 Omrix Biopharm Sa Applikator zum Auftragen eines Ein- oder Mehrkomponenten-Fluids und Verfahren zum Aufsprühen eines derartigen Fluids
US6475182B1 (en) * 1997-03-12 2002-11-05 Olexander Hnojewyj Fluidic media introduction apparatus
WO1998042260A1 (en) * 1997-03-27 1998-10-01 Bristol-Myers Squibb Company Laparoscopic sealant applicator
WO1998046300A1 (en) 1997-04-14 1998-10-22 Biosurgical Corporation Fluid applicator for dispensing measured quantities with use of controlled suction
US6331172B1 (en) 1997-04-14 2001-12-18 Baxter International Inc. Applicator for dispensing measured quantities with use of controlled suction
US5971956A (en) * 1997-04-15 1999-10-26 Biosurgical Corporation Medical suctioning apparatus and methods of use
US6733472B1 (en) 1997-04-14 2004-05-11 Baxter International Inc. Sealant applicator tip and application method
WO1999002207A1 (en) 1997-07-11 1999-01-21 United States Surical Corp. Fibrin glue applicator system
US6458095B1 (en) 1997-10-22 2002-10-01 3M Innovative Properties Company Dispenser for an adhesive tissue sealant having a housing with multiple cavities
AU1114599A (en) 1997-10-22 1999-05-10 Minnesota Mining And Manufacturing Company Dispenser for an adhesive tissue sealant
US6079868A (en) * 1997-12-18 2000-06-27 Advanced Bio Surfaces, Inc. Static mixer
DE69842146D1 (de) 1997-12-19 2011-04-07 Tyco Healthcare Spenderanordnung für Fibringemisch
AU745893B2 (en) 1997-12-19 2002-04-11 United States Surgical Corporation Two component dispenser system
US6762336B1 (en) 1998-01-19 2004-07-13 The American National Red Cross Hemostatic sandwich bandage
US6568434B2 (en) 1998-02-04 2003-05-27 Omrix Biopharmaceuticals S.A. Receiver cup for a vessel housing a medicinal substance
AU2723399A (en) 1998-02-04 1999-08-23 Omrix Biopharmaceuticals S.A. Device for storing a liquid medicinal substance
US6884230B1 (en) 1998-03-09 2005-04-26 Baxter International Inc. Dispensing head for a tissue sealant applicator and process of use
US6047861A (en) * 1998-04-15 2000-04-11 Vir Engineering, Inc. Two component fluid dispenser
US6461361B1 (en) 1998-05-01 2002-10-08 Baxter International Inc. Gas-driven spraying of mixed sealant agents
JP2002515309A (ja) 1998-05-21 2002-05-28 バクスター・インターナショナル・インコーポレイテッド シーラントアプリケータおよび衝撃洗浄を使用する方法
US6475183B1 (en) 1998-06-03 2002-11-05 Baxter International Inc. Direct dual filling device for sealing agents
US6274090B1 (en) 1998-08-05 2001-08-14 Thermogenesis Corp. Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
US6179862B1 (en) * 1998-08-14 2001-01-30 Incept Llc Methods and apparatus for in situ formation of hydrogels
AU6151799A (en) 1998-09-17 2000-04-03 Focal, Inc. Self-cleaning fluid delivery device for medical applications
JP4115669B2 (ja) * 1998-10-01 2008-07-09 バクスター・インターナショナル・インコーポレイテッド 改良された成分混合用カテーテル
US6921380B1 (en) 1998-10-01 2005-07-26 Baxter International Inc. Component mixing catheter
US6471670B1 (en) 1998-10-05 2002-10-29 Karl Enrenfels Fibrin sealant applicator system
BE1012536A3 (fr) 1998-11-04 2000-12-05 Baxter Int Element muni d'une couche de fibrine sa preparation et son utilisation.
US20080114092A1 (en) * 1998-12-04 2008-05-15 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
CA2353642C (en) 1998-12-04 2009-11-10 Amarpreet S. Sawhney Biocompatible crosslinked polymers
DE19910972C1 (de) * 1999-03-09 2000-10-26 Omrix Biopharm Sa Vorrichtung zum Auftragen eines fließfähigen Mediums, insbesondere eines Gewebeklebstoffs
ATA49899A (de) 1999-03-19 2002-06-15 Immuno Ag Verfahren und vorrichtung zum mischen von komponenten
US6472162B1 (en) 1999-06-04 2002-10-29 Thermogenesis Corp. Method for preparing thrombin for use in a biological glue
US7654998B1 (en) 1999-08-23 2010-02-02 Aeris Therapeutics, Inc. Tissue volume reduction
US6610043B1 (en) 1999-08-23 2003-08-26 Bistech, Inc. Tissue volume reduction
CA2316554C (en) * 1999-08-25 2007-10-23 Bristol-Myers Squibb Company Applicator and electro-mechanical applicator drive system
US20020055708A1 (en) * 1999-09-24 2002-05-09 Peterson Kenneth R. Coupling syringe system and methods for obtaining a mixed composition
US8226598B2 (en) 1999-09-24 2012-07-24 Tolmar Therapeutics, Inc. Coupling syringe system and methods for obtaining a mixed composition
US6566144B1 (en) 2000-03-27 2003-05-20 Atrix Laboratories Cover plate for use in lyophilization
US6626870B1 (en) 2000-03-27 2003-09-30 Artix Laboratories, Inc. Stoppering method to maintain sterility
JP2001333980A (ja) * 2000-05-26 2001-12-04 Ookisu:Kk 薬液持続注入器
EP1301245A4 (en) * 2000-07-17 2007-02-28 Haemacure Corp SPRAY HEAD FOR APPLYING A MIXTURE WITH MULTIPLE COMPONENTS
US6506365B1 (en) 2000-09-25 2003-01-14 Baxter Aktiengesellschaft Fibrin/fibrinogen binding conjugate
WO2002030445A2 (en) * 2000-10-13 2002-04-18 Baxter International Inc. Fibrinogen plus a non-plasmin-acting fibrinolysis inhibitor for the reduction or prevention of adhesion formation
CA2325842C (en) * 2000-11-02 2007-08-07 Lisa Mckerracher Methods for making and delivering rho-antagonist tissue adhesive formulations to the injured mammalian central and peripheral nervous systems and uses thereof
US20020165483A1 (en) * 2000-11-10 2002-11-07 Curtis Miller Gas assisted spray applicator
US6648911B1 (en) 2000-11-20 2003-11-18 Avantec Vascular Corporation Method and device for the treatment of vulnerable tissue site
US7175336B2 (en) 2001-01-26 2007-02-13 Depuy Acromed, Inc. Graft delivery system
EP1917914B1 (en) 2001-02-27 2009-07-08 Tyco Healthcare Group Lp External mixer assembly
CA2766682A1 (en) 2001-02-27 2002-09-06 Tyco Healthcare Group Lp External mixer assembly
JP4736204B2 (ja) * 2001-02-28 2011-07-27 ブラザー工業株式会社 ギアチェンジ装置およびそれを使用した通信装置
US6723067B2 (en) 2001-07-26 2004-04-20 David H. Nielson Apparatus for delivering aerosolized fibrin endoscopically to a wound
US7544177B2 (en) * 2002-01-24 2009-06-09 The Regents Of The University Of California Aerosol device to deliver bioactive agent
US20030229333A1 (en) * 2002-02-22 2003-12-11 Control Delivery Systems, Inc. Methods for treating otic disorders
US6732887B2 (en) * 2002-03-26 2004-05-11 Ultradent Products, Inc. Two-part composition syringe delivery system
US6863660B2 (en) 2002-03-27 2005-03-08 Hapio Biotech, Inc. Fibrin applicator pistol
US6644365B1 (en) 2002-04-19 2003-11-11 Baxter International, Inc. Tilting direct dual filling device
US7374678B2 (en) 2002-05-24 2008-05-20 Biomet Biologics, Inc. Apparatus and method for separating and concentrating fluids containing multiple components
US7832566B2 (en) 2002-05-24 2010-11-16 Biomet Biologics, Llc Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles
US7992725B2 (en) 2002-05-03 2011-08-09 Biomet Biologics, Llc Buoy suspension fractionation system
US20030205538A1 (en) 2002-05-03 2003-11-06 Randel Dorian Methods and apparatus for isolating platelets from blood
US20060278588A1 (en) 2002-05-24 2006-12-14 Woodell-May Jennifer E Apparatus and method for separating and concentrating fluids containing multiple components
US7845499B2 (en) 2002-05-24 2010-12-07 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
DE10392686T5 (de) 2002-05-24 2005-07-07 Biomet Mfg. Corp., Warsaw Vorrichtung und Verfahren zum Trennen und Konzentrieren von Flüssigkeiten, welche mehrere Komponenten enthalten
US6936033B2 (en) * 2002-06-14 2005-08-30 Medtronic, Inc. Multiple ratio fluid dispenser
SE0201673L (sv) * 2002-06-03 2003-05-06 Cemvac System Ab Anordning för utmatning av en monomer till en med en polymer förfylld blandningsanordning för tillredning av bencement
US6852099B2 (en) * 2002-06-04 2005-02-08 Baxter International Inc. Device for controllably applying liquids to body surfaces
CA2498212C (en) 2002-09-10 2012-07-17 American National Red Cross Multi-layered hemostatic dressing comprising thrombin and fibrinogen
US7217254B2 (en) 2002-09-20 2007-05-15 Genzyme Corporation Multi-pressure biocompatible agent delivery device and method
US7135027B2 (en) 2002-10-04 2006-11-14 Baxter International, Inc. Devices and methods for mixing and extruding medically useful compositions
US7077339B2 (en) * 2003-02-03 2006-07-18 Biomet, Inc. Spray applicator
US20050032205A1 (en) * 2003-08-05 2005-02-10 Smith Sidney T. In vitro cell culture employing a fibrin network in a flexible gas permeable container
US7610943B2 (en) * 2004-06-10 2009-11-03 Emerald Biosystems, Inc. Systems and methods for dispensing portions of viscous material
US8206448B2 (en) * 2004-10-29 2012-06-26 Spinal Restoration, Inc. Injection of fibrin sealant using reconstituted components in spinal applications
US7597687B2 (en) 2004-10-29 2009-10-06 Spinal Restoration, Inc. Injection of fibrin sealant including an anesthetic in spinal applications
DE102004041631A1 (de) 2004-08-27 2006-03-02 Herbert Maslanka Sprühsonde
US7490738B2 (en) * 2004-10-01 2009-02-17 Angiotech Pharmaceuticals (Us), Inc. Mixing and dispensing fluid components of a multicomponent composition
AU2005309599A1 (en) * 2004-11-23 2006-06-01 Smith & Nephew, Inc. Composite mixer
JP4961354B2 (ja) 2005-02-07 2012-06-27 ハヌマン リミテッド ライアビリティ カンパニー 多血小板血漿濃縮装置および方法
WO2006086201A2 (en) 2005-02-07 2006-08-17 Hanuman Llc Platelet rich plasma concentrate apparatus and method
US7866485B2 (en) 2005-02-07 2011-01-11 Hanuman, Llc Apparatus and method for preparing platelet rich plasma and concentrates thereof
US7611494B2 (en) 2005-02-08 2009-11-03 Confluent Surgical, Inc. Spray for fluent materials
CA2595633C (en) 2005-02-09 2013-11-19 Ahmad R. Hadba Synthetic sealants
US7766900B2 (en) 2005-02-21 2010-08-03 Biomet Manufacturing Corp. Method and apparatus for application of a fluid
US7635343B2 (en) * 2005-04-21 2009-12-22 Arteriocyte Medical Systems, Inc. Fluid dispenser
GB2441460A (en) * 2005-06-06 2008-03-05 Colour Revolution Inc Method to apply a hair care preparation and kit for same
US20060272108A1 (en) * 2005-06-06 2006-12-07 Ruth Stern Method to apply a hair care preparation and kit for same
US7468049B2 (en) * 2005-06-14 2008-12-23 Rieke Corporation Dual syringe adapter
US7575131B2 (en) * 2005-07-13 2009-08-18 Ethicon, Inc. Multi-component delivery system
EP2213245B1 (en) 2006-01-17 2012-07-04 Baxter International Inc. Device and method for mixing
US20090038701A1 (en) 2006-01-17 2009-02-12 Baxter International Inc. Device, system and method for mixing
ATE540764T1 (de) * 2006-02-24 2012-01-15 Sulzer Mixpac Ag Ausgabevorrichtung für eine doppelspritze
US7837656B2 (en) * 2006-03-27 2010-11-23 Tyco Healthcare Group Lp Dual air regulated spray applicator
WO2007127198A2 (en) 2006-04-24 2007-11-08 Incept, Llc Protein crosslinkers, crosslinking methods and applications thereof
US8567609B2 (en) 2006-05-25 2013-10-29 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
WO2008019129A2 (en) * 2006-08-04 2008-02-14 Stb Lifesaving Technologies, Inc. Solid dressing for treating wounded tissue
US7708208B1 (en) 2006-10-02 2010-05-04 Ingo Werner Scheer Method and apparatus to disintegrate liquids having a tendency to solidify
US7749235B2 (en) 2006-10-20 2010-07-06 Ethicon Endo-Surgery, Inc. Stomach invagination method and apparatus
US7658305B2 (en) 2006-10-25 2010-02-09 Ethicon Endo-Surgery, Inc. Adhesive applier with articulating tip
US8876844B2 (en) 2006-11-01 2014-11-04 Ethicon Endo-Surgery, Inc. Anastomosis reinforcement using biosurgical adhesive and device
US7892250B2 (en) 2006-11-01 2011-02-22 Ethicon Endo-Surgery, Inc. Use of biosurgical adhesive on inflatable device for gastric restriction
US7833216B2 (en) 2006-11-08 2010-11-16 Ethicon Endo-Surgery, Inc. Fluid plunger adhesive dispenser
US7699803B2 (en) * 2007-01-03 2010-04-20 Medtronic Vascular, Inc. Devices and methods for injection of multiple-component therapies
US20090227689A1 (en) 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
US20090227981A1 (en) 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
US20080220047A1 (en) 2007-03-05 2008-09-11 Sawhney Amarpreet S Low-swelling biocompatible hydrogels
US8328024B2 (en) 2007-04-12 2012-12-11 Hanuman, Llc Buoy suspension fractionation system
US7806276B2 (en) 2007-04-12 2010-10-05 Hanuman, Llc Buoy suspension fractionation system
US20080267005A1 (en) * 2007-04-24 2008-10-30 Tyco Healthcare Group Lp Applicator system and method of use
US20090075891A1 (en) * 2007-08-06 2009-03-19 Macphee Martin Methods and dressings for sealing internal injuries
US8067028B2 (en) 2007-08-13 2011-11-29 Confluent Surgical Inc. Drug delivery device
WO2009055703A1 (en) * 2007-10-25 2009-04-30 Plantation Key Design Inc. Adjustable spray pattern atomizer
WO2009097271A1 (en) * 2008-01-28 2009-08-06 Baxter International Inc Sealant application with malleable section
EP2259774B1 (en) 2008-02-27 2012-12-12 Biomet Biologics, LLC Methods and compositions for delivering interleukin-1 receptor antagonist
US8337711B2 (en) 2008-02-29 2012-12-25 Biomet Biologics, Llc System and process for separating a material
JP5222591B2 (ja) * 2008-03-12 2013-06-26 テルモ株式会社 塗布具
US8512740B2 (en) * 2008-03-26 2013-08-20 Baxter International Inc. Fibrin foam and process for making
US8753670B2 (en) 2008-03-26 2014-06-17 Baxter International Inc. Fibrin foam and process
US8518272B2 (en) 2008-04-04 2013-08-27 Biomet Biologics, Llc Sterile blood separating system
US8182769B2 (en) 2008-04-04 2012-05-22 Biomet Biologics, Llc Clean transportation system
US8408480B2 (en) * 2008-04-25 2013-04-02 Confluent Surgical, Inc. Self-cleaning spray tip
US8033483B2 (en) 2008-04-25 2011-10-11 Confluent Surgical Inc. Silicone spray tip
JP2011519679A (ja) 2008-05-06 2011-07-14 ウィルソン−クック・メディカル・インコーポレーテッド 治療薬を送達するための器具及び方法
US8012077B2 (en) 2008-05-23 2011-09-06 Biomet Biologics, Llc Blood separating device
US8210453B2 (en) 2008-09-12 2012-07-03 Confluent Surgical, Inc. Spray applicator
JP5255386B2 (ja) * 2008-09-24 2013-08-07 テルモ株式会社 塗布具
US9681860B2 (en) 2008-10-24 2017-06-20 Dennis L Steffen Halo tip spray head atomizer delivery manifold device
US20110264122A1 (en) * 2008-11-11 2011-10-27 Mauro Bonino Device for applying glue on tissues to be connected
WO2010074949A1 (en) 2008-12-23 2010-07-01 Wilson-Cook Medical Inc. Apparatus and methods for containing and delivering therapeutic agents
US8187475B2 (en) 2009-03-06 2012-05-29 Biomet Biologics, Llc Method and apparatus for producing autologous thrombin
CN102365101A (zh) 2009-03-27 2012-02-29 阿克塔马克斯手术器材有限责任公司 包含聚甘油醛的组织粘合剂和密封剂
CN102361911A (zh) 2009-03-27 2012-02-22 阿克塔马克斯手术器材有限责任公司 聚甘油醛
US20100246316A1 (en) * 2009-03-31 2010-09-30 Baxter International Inc. Dispenser, kit and mixing adapter
US8313954B2 (en) 2009-04-03 2012-11-20 Biomet Biologics, Llc All-in-one means of separating blood components
CA2666080A1 (en) * 2009-05-14 2010-11-14 Colour Revolution Inc. Applicator
US20100297235A1 (en) * 2009-05-20 2010-11-25 Cpc Of America, Inc. Vascular puncture closure systems, devices, and methods using biocompatible synthetic hydrogel compositions
US8118777B2 (en) 2009-05-29 2012-02-21 Cook Medical Technologies Llc Systems and methods for delivering therapeutic agents
US9101744B2 (en) 2009-05-29 2015-08-11 Cook Medical Technologies Llc Systems and methods for delivering therapeutic agents
ES2332032B1 (es) * 2009-06-09 2010-06-07 Grifols, S.A. Dispositivo de aplicacion de adhesivo de fibrina.
WO2011002888A2 (en) 2009-07-02 2011-01-06 E. I. Du Pont De Nemours And Company Hydrogel tissue adhesive for medical use
US9011800B2 (en) 2009-07-16 2015-04-21 Biomet Biologics, Llc Method and apparatus for separating biological materials
EP2475308A1 (en) 2009-09-08 2012-07-18 Baxter International Inc Reconstitution and applicator system for wound sealant product
US20110081398A1 (en) * 2009-10-01 2011-04-07 Tyco Healthcare Group Lp Multi-mechanism surgical compositions
US8968785B2 (en) * 2009-10-02 2015-03-03 Covidien Lp Surgical compositions
US20110081701A1 (en) * 2009-10-02 2011-04-07 Timothy Sargeant Surgical compositions
US9445795B2 (en) * 2009-10-16 2016-09-20 Confluent Surgical, Inc. Prevention of premature gelling of delivery devices for pH dependent forming materials
US20110091549A1 (en) * 2009-10-16 2011-04-21 Confluent Surgical, Inc. Modulating Drug Release Rate By Controlling The Kinetics Of The pH Transition In Hydrogels
US20110092922A1 (en) 2009-10-19 2011-04-21 Trompen Mick A Transdermal dispensing apparatus and methods
US9498271B2 (en) * 2009-10-29 2016-11-22 Cook Medical Technologies Llc Coaxial needle cannula with distal spiral mixer and side ports for fluid injection
US8641661B2 (en) * 2010-01-05 2014-02-04 Baxter International Inc. Mixing system, kit and mixer adapter
CA2726566A1 (en) * 2010-01-11 2011-07-11 Baxter International Inc. Pipette system, pipette tip assembly and kit
RU2556960C2 (ru) * 2010-01-28 2015-07-20 Омрикс Биофармасьютикалс Лтд. Способ обеспечения улучшенного уплотнения с помощью фибрина
US8608642B2 (en) 2010-02-25 2013-12-17 Ethicon Endo-Surgery, Inc. Methods and devices for treating morbid obesity using hydrogel
EP2542172B1 (en) 2010-03-01 2018-07-11 Cook Medical Technologies LLC Thermo-chemical medical device for manipulation of tissue
CA2730598C (en) 2010-03-16 2018-03-13 Confluent Surgical, Inc. Modulating drug release rate by controlling the kinetics of the ph transition in hydrogels
EP3590567B1 (en) * 2010-04-05 2023-10-04 Neomend, Inc. Device for delivering hydrogel compositions with self-purging to prevent clogging
US8591391B2 (en) 2010-04-12 2013-11-26 Biomet Biologics, Llc Method and apparatus for separating a material
US8697111B2 (en) 2010-05-12 2014-04-15 Covidien Lp Osteochondral implant comprising osseous phase and chondral phase
US8734930B2 (en) 2010-05-27 2014-05-27 Covidien Lp Hydrogel implants with varying degrees of crosslinking
US8883185B2 (en) 2010-05-27 2014-11-11 Covidien Lp Hydrogel implants with varying degrees of crosslinking
US8754564B2 (en) 2010-05-27 2014-06-17 Covidien Lp Hydrogel implants with varying degrees of crosslinking
US8591950B2 (en) 2010-05-27 2013-11-26 Covidien Lp Hydrogel implants with varying degrees of crosslinking
US8591929B2 (en) 2010-05-27 2013-11-26 Covidien Lp Hydrogel implants with varying degrees of crosslinking
US8968783B2 (en) 2010-05-27 2015-03-03 Covidien Lp Hydrogel implants with varying degrees of crosslinking
US8734824B2 (en) 2010-05-27 2014-05-27 Covidien LLP Hydrogel implants with varying degrees of crosslinking
US9211554B2 (en) 2010-06-30 2015-12-15 Actamax Surgical Materials, Llc Self-contained hand-held direct drive device for dispensing a two-part adhesive aerosol
US8678238B2 (en) 2010-06-30 2014-03-25 Actamax Surgical Materials, Llc Self-contained hand-held yoke-connected device for dispensing a two-part adhesive aerosol
US20120065600A1 (en) * 2010-09-10 2012-03-15 E. I. Du Pont De Nemours And Company. Device for dispensing microliter quantities of a material into a longitudinally extending wound site
US9392929B2 (en) * 2010-10-14 2016-07-19 Medivators Inc. Connector comprising backflow valve for a tube set
US8518440B2 (en) 2010-12-21 2013-08-27 Confluent Surgical, Inc. Biodegradable osmotic pump implant for drug delivery
US8440309B2 (en) 2011-01-31 2013-05-14 Confluent Surgical, Inc. Crosslinked polymers with the crosslinker as therapeutic for sustained release
AU2012232814A1 (en) 2011-03-24 2013-10-03 Sofradim Production Enzymatically degradable compositions
TW201245221A (en) 2011-05-02 2012-11-16 Baxter Int FGF based fibrin binding peptides
US10849931B2 (en) 2011-09-30 2020-12-01 Depuy Synthes Products, Inc Compositions and methods for platelet enriched fibrin constructs
US9486190B2 (en) * 2011-10-28 2016-11-08 Medtronic Xomed, Inc. Spray delivery system
US10309430B2 (en) 2012-08-10 2019-06-04 Confluent Surgical, Inc. Pneumatic actuation assembly
WO2014031150A1 (en) * 2012-08-24 2014-02-27 St. Jude Medical Puerto Rico Llc Sealant storage, preparation, and delivery systems and related methods
US9642956B2 (en) 2012-08-27 2017-05-09 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US9381005B2 (en) 2012-10-26 2016-07-05 Baxter International Inc. Spray head for two component mixer
US9895418B2 (en) 2013-03-15 2018-02-20 Biomet Biologics, Llc Treatment of peripheral vascular disease using protein solutions
US20140271589A1 (en) 2013-03-15 2014-09-18 Biomet Biologics, Llc Treatment of collagen defects using protein solutions
US10208095B2 (en) 2013-03-15 2019-02-19 Biomet Manufacturing, Llc Methods for making cytokine compositions from tissues using non-centrifugal methods
US20140276379A1 (en) 2013-03-15 2014-09-18 Medrad, Inc. Intelligent and configurable fluid delivery system and methods for its use
US10143725B2 (en) 2013-03-15 2018-12-04 Biomet Biologics, Llc Treatment of pain using protein solutions
US9867931B2 (en) 2013-10-02 2018-01-16 Cook Medical Technologies Llc Therapeutic agents for delivery using a catheter and pressure source
US11931227B2 (en) 2013-03-15 2024-03-19 Cook Medical Technologies Llc Bimodal treatment methods and compositions for gastrointestinal lesions with active bleeding
US9950035B2 (en) 2013-03-15 2018-04-24 Biomet Biologics, Llc Methods and non-immunogenic compositions for treating inflammatory disorders
EP3027659B1 (en) 2013-07-29 2020-12-09 Actamax Surgical Materials LLC Low swell tissue adhesive and sealant formulations
WO2015034870A2 (en) * 2013-09-03 2015-03-12 Arocha Max Double-chamber mixing syringe and method of use
US9586005B2 (en) 2013-09-30 2017-03-07 Dennis L Steffen Dual syringe delivery device and method of use
US10952709B2 (en) 2014-04-04 2021-03-23 Hyperbranch Medical Technology, Inc. Extended tip spray applicator for two-component surgical sealant, and methods of use thereof
CH709684A1 (de) * 2014-05-22 2015-11-30 Medmix Systems Ag Laparoskopischer Sprayapplikator und Adapter.
US11382731B2 (en) 2015-02-27 2022-07-12 Covidien Lp Medical devices with sealing properties
US9713810B2 (en) 2015-03-30 2017-07-25 Biomet Biologics, Llc Cell washing plunger using centrifugal force
US9757721B2 (en) 2015-05-11 2017-09-12 Biomet Biologics, Llc Cell washing plunger using centrifugal force
US9572555B1 (en) * 2015-09-24 2017-02-21 Ethicon, Inc. Spray or drip tips having multiple outlet channels
EP3831440A1 (en) * 2016-10-17 2021-06-09 Bayer Healthcare LLC Fluid control valve and manifold
US11202848B2 (en) 2017-03-08 2021-12-21 Baxter International Inc. Surgical adhesive able to glue in wet conditions
US10912859B2 (en) 2017-03-08 2021-02-09 Baxter International Inc. Additive able to provide underwater adhesion
IL261190A (en) 2018-08-16 2019-01-31 Omrix Biopharmaceuticals Ltd Stable liquid preparations of thrombin
ES2968105T3 (es) * 2020-10-02 2024-05-07 Capsugel Belgium Nv Dispositivo para dispensar gotas individuales en una tapa o cuerpo de una cápsula
CN118119418A (zh) * 2021-10-22 2024-05-31 波士顿科学医疗设备有限公司 用于生产混合物的系统
US12114843B2 (en) * 2022-03-31 2024-10-15 Ethicon, Inc. Sealant applicators having mixing and spraying assemblies with malleable sections and spray tips having reduced dimensions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56152641A (en) * 1980-04-02 1981-11-26 Immuno Ag Apparatus for applying tissue adhesive based on human or animal protein
US4406656A (en) * 1981-06-01 1983-09-27 Brack Gillium Hattler Venous catheter having collapsible multi-lumens

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2112160A (en) * 1933-04-04 1938-03-22 Kenneth Fredericks Method of and apparatus for effecting medicinal treatment
US4040420A (en) * 1976-04-22 1977-08-09 General Dynamics Packaging and dispensing kit
DE8119976U1 (de) * 1981-07-08 1982-02-25 Haaga, Gustav Adolf Schutzschlauch aus duennem folienmaterial fuer katheterschlaeuche oder dergleichen

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56152641A (en) * 1980-04-02 1981-11-26 Immuno Ag Apparatus for applying tissue adhesive based on human or animal protein
US4406656A (en) * 1981-06-01 1983-09-27 Brack Gillium Hattler Venous catheter having collapsible multi-lumens

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08281150A (ja) * 1995-04-18 1996-10-29 Nissho Corp 生体組織接着剤スプレー用ノズル
JPH1176245A (ja) * 1997-09-09 1999-03-23 Nissho Corp 生体組織接着剤投与具

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US4631055A (en) 1986-12-23
ES8603254A1 (es) 1985-12-16
EP0156098B1 (de) 1989-11-02
EP0315222B1 (de) 1992-11-19
DE3485993D1 (de) 1992-12-24
DK165485C (da) 1993-04-19
ATA106384A (de) 1985-05-15
AT379311B (de) 1985-12-27
EP0315222A2 (de) 1989-05-10
ES541272A0 (es) 1985-12-16
CA1225560A (en) 1987-08-18
DE3480328D1 (en) 1989-12-07
EP0315222A3 (en) 1990-01-03
DK96785A (da) 1985-09-30
DK96785D0 (da) 1985-03-01
EP0156098A2 (de) 1985-10-02
ATE47672T1 (de) 1989-11-15
EP0156098A3 (en) 1986-07-30
JPS60225567A (ja) 1985-11-09
DK165485B (da) 1992-12-07
ATE82518T1 (de) 1992-12-15

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