JPH0368555A - １，４―ジヒドロピリジン誘導体、その製造方法及びこれを含有する心臓血管疾患又は高血圧治療剤 - Google Patents

１，４―ジヒドロピリジン誘導体、その製造方法及びこれを含有する心臓血管疾患又は高血圧治療剤

Info

Publication number
JPH0368555A
JPH0368555A JP1277316A JP27731689A JPH0368555A JP H0368555 A JPH0368555 A JP H0368555A JP 1277316 A JP1277316 A JP 1277316A JP 27731689 A JP27731689 A JP 27731689A JP H0368555 A JPH0368555 A JP H0368555A
Authority
JP
Japan
Prior art keywords
group
general formula
dihydropyridine
atom
dihydropyridine derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1277316A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0565509B2 (enExample
Inventor
Choong Sup Kim
金　忠燮
Jong-Jin Suh
徐　延珍
Bong Yong Lee
李　峰▲ゆ▼
Chang-Seob Kim
昌燮 金
Jong Wook Lee
李　鍾郁
Byung Chae Kim
金　炳采
Byung Hee Han
韓　秉煕
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yuhan Corp
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yuhan Corp filed Critical Yuhan Corp
Publication of JPH0368555A publication Critical patent/JPH0368555A/ja
Publication of JPH0565509B2 publication Critical patent/JPH0565509B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP1277316A 1988-10-27 1989-10-26 １，４―ジヒドロピリジン誘導体、その製造方法及びこれを含有する心臓血管疾患又は高血圧治療剤 Granted JPH0368555A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1019880014022A KR940003492B1 (ko) 1988-10-27 1988-10-27 1,4-디하이드로피리딘유도체 및 그의 제조방법
KR14022/1988 1988-10-27

Publications (2)

Publication Number Publication Date
JPH0368555A true JPH0368555A (ja) 1991-03-25
JPH0565509B2 JPH0565509B2 (enExample) 1993-09-17

Family

ID=19278797

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1277316A Granted JPH0368555A (ja) 1988-10-27 1989-10-26 １，４―ジヒドロピリジン誘導体、その製造方法及びこれを含有する心臓血管疾患又は高血圧治療剤

Country Status (5)

Country Link
US (1) US5089624A (enExample)
EP (1) EP0366548B1 (enExample)
JP (1) JPH0368555A (enExample)
KR (1) KR940003492B1 (enExample)
DE (1) DE68906854T2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007084567A (ja) * 1993-12-10 2007-04-05 Bayer Ag フエニル−置換１，４−ジヒドロピリジン類

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3286645B2 (ja) * 1993-03-26 2002-05-27 メルシャン株式会社 光学活性１，４−ジヒドロピリジン誘導体およびその製造方法
SE9303657D0 (sv) * 1993-11-05 1993-11-05 Astra Ab Short-acting dihydropyridines

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51108075A (enExample) * 1975-02-26 1976-09-25 Bayer Ag
JPS5470284A (en) * 1977-10-22 1979-06-05 Bayer Ag Novel dihydropyridine compounds*its manufacture and use
JPS5583783A (en) * 1978-12-18 1980-06-24 Sandoz Ag 1*44dihydropyridine derivative
JPS6094963A (ja) * 1983-10-31 1985-05-28 Teijin Ltd １，４−ジヒドロピリジン−３，５−ジカルボン酸ジエステル誘導体及びその製造法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670824C3 (de) * 1967-03-20 1978-08-03 Bayer Ag, 5090 Leverkusen 1,4-Dihydropyridin-33-dicarbonsäurealkylester
US4600778A (en) * 1983-04-05 1986-07-15 Bayer Aktiengesellschaft Process for the preparation of 1,4-dihydropyridinedicarboxylic esters

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51108075A (enExample) * 1975-02-26 1976-09-25 Bayer Ag
JPS5470284A (en) * 1977-10-22 1979-06-05 Bayer Ag Novel dihydropyridine compounds*its manufacture and use
JPS5583783A (en) * 1978-12-18 1980-06-24 Sandoz Ag 1*44dihydropyridine derivative
JPS6094963A (ja) * 1983-10-31 1985-05-28 Teijin Ltd １，４−ジヒドロピリジン−３，５−ジカルボン酸ジエステル誘導体及びその製造法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007084567A (ja) * 1993-12-10 2007-04-05 Bayer Ag フエニル−置換１，４−ジヒドロピリジン類

Also Published As

Publication number Publication date
EP0366548A1 (en) 1990-05-02
KR900006292A (ko) 1990-05-07
DE68906854D1 (en) 1993-07-08
KR940003492B1 (ko) 1994-04-23
EP0366548B1 (en) 1993-06-02
JPH0565509B2 (enExample) 1993-09-17
DE68906854T2 (de) 1994-01-13
US5089624A (en) 1992-02-18

Similar Documents

Publication Publication Date Title
KR910002583B1 (ko) 피페라진 유도체 또는 이의 염, 이의 제조방법 및 활성 성분으로서 이를 함유하는 약제학적 조성물
DK160549B (da) Analogifremgangsmaade til fremstilling af antipoder i s-form af chirale 1,4-dihydropyridincarboxylsyreestere
KR860001946B1 (ko) 1, 4-디히드로피리딘 유도체의 제조방법
KR910005706B1 (ko) 벤조티아진 유도체의 제조방법
JPH0378390B2 (enExample)
JPS6360755B2 (enExample)
EP0289746B1 (en) 1,4-Dihydropyridine derivatives and pharmaceutical composition thereof
US4642310A (en) Circulation-active tetrahydrothienopyridines
JPH0368555A (ja) １，４―ジヒドロピリジン誘導体、その製造方法及びこれを含有する心臓血管疾患又は高血圧治療剤
US4874773A (en) 3-Aminocarbonyl-1,4-dihydropyridine-5-carboxylic acid compounds, and pharmaceutical composition containing the same
CN113429396A (zh) 一种五元杂芳环衍生物及其制备方法和用途
HU194543B (en) Process for preparing 1,4-dihydro-pyridine-hydroxy-amine derivatives and pharmaceutical compositions comprising the same as active substance
US4992451A (en) 1,4-dihydropyridine derivatives
JPH0379359B2 (enExample)
US5100892A (en) Dihydropyridine vasodilator agents
FI85491B (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara fosfonsyraderivat.
JP3049284B2 (ja) ヒダントイン誘導体並びにそれを有効成分とする糖尿病合併症及び循環器系疾患の予防及び治療剤
JPH0357903B2 (enExample)
US5258519A (en) Dihydropyridine vasodilators agents
JPS63233992A (ja) ジヒドロピリジン−５−ホスホン酸環状エステル類
JPH0559107B2 (enExample)
JPH07215965A (ja) インドールスルホンアミド−置換ジヒドロピリジン類
JP3096757B2 (ja) ３−オキソ−１，４−ベンゾオキサジン誘導体
JPH0755955B2 (ja) 光学活性なジヒドロピリジン−５−ホスホン酸エステル
KR860001947B1 (ko) 1,4-디히드로피리딘 유도체의 제조방법