JPH0359703B2 - - Google Patents
Info
- Publication number
- JPH0359703B2 JPH0359703B2 JP58247226A JP24722683A JPH0359703B2 JP H0359703 B2 JPH0359703 B2 JP H0359703B2 JP 58247226 A JP58247226 A JP 58247226A JP 24722683 A JP24722683 A JP 24722683A JP H0359703 B2 JPH0359703 B2 JP H0359703B2
- Authority
- JP
- Japan
- Prior art keywords
- granules
- bone
- pores
- calcium phosphate
- microns
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000008187 granular material Substances 0.000 claims description 70
- 239000011148 porous material Substances 0.000 claims description 57
- 239000000203 mixture Substances 0.000 claims description 37
- 239000002639 bone cement Substances 0.000 claims description 35
- 239000001506 calcium phosphate Substances 0.000 claims description 35
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 34
- 235000011010 calcium phosphates Nutrition 0.000 claims description 34
- -1 calcium phosphate compound Chemical class 0.000 claims description 30
- 210000001519 tissue Anatomy 0.000 claims description 15
- 239000011575 calcium Substances 0.000 claims description 12
- 239000002473 artificial blood Substances 0.000 claims description 8
- 210000004369 blood Anatomy 0.000 claims description 8
- 239000008280 blood Substances 0.000 claims description 8
- 239000002504 physiological saline solution Substances 0.000 claims description 8
- 239000011800 void material Substances 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 6
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 2
- 229910052791 calcium Inorganic materials 0.000 claims description 2
- 229910052698 phosphorus Inorganic materials 0.000 claims description 2
- 239000011574 phosphorus Substances 0.000 claims description 2
- 210000000988 bone and bone Anatomy 0.000 description 47
- 239000002245 particle Substances 0.000 description 40
- 239000000843 powder Substances 0.000 description 25
- 239000000835 fiber Substances 0.000 description 15
- 239000000057 synthetic resin Substances 0.000 description 14
- 229920003002 synthetic resin Polymers 0.000 description 14
- 239000000463 material Substances 0.000 description 12
- 210000004027 cell Anatomy 0.000 description 11
- 238000000034 method Methods 0.000 description 11
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- 210000004394 hip joint Anatomy 0.000 description 9
- 239000000126 substance Substances 0.000 description 9
- 230000011164 ossification Effects 0.000 description 8
- 210000001185 bone marrow Anatomy 0.000 description 7
- 230000018109 developmental process Effects 0.000 description 7
- 238000010438 heat treatment Methods 0.000 description 6
- 238000005245 sintering Methods 0.000 description 6
- 102000008186 Collagen Human genes 0.000 description 5
- 108010035532 Collagen Proteins 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 229910010293 ceramic material Inorganic materials 0.000 description 5
- 229920001436 collagen Polymers 0.000 description 5
- 230000007547 defect Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 230000001172 regenerating effect Effects 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 229910019142 PO4 Inorganic materials 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- 210000001503 joint Anatomy 0.000 description 4
- 210000001539 phagocyte Anatomy 0.000 description 4
- 239000006104 solid solution Substances 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- 230000007306 turnover Effects 0.000 description 4
- 210000000689 upper leg Anatomy 0.000 description 4
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 3
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 3
- 239000004568 cement Substances 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 210000003743 erythrocyte Anatomy 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 3
- 239000004926 polymethyl methacrylate Substances 0.000 description 3
- 229920005989 resin Polymers 0.000 description 3
- 239000011347 resin Substances 0.000 description 3
- 210000004872 soft tissue Anatomy 0.000 description 3
- 238000005979 thermal decomposition reaction Methods 0.000 description 3
- 229910014497 Ca10(PO4)6(OH)2 Inorganic materials 0.000 description 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 230000010478 bone regeneration Effects 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 230000009545 invasion Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 239000011343 solid material Substances 0.000 description 2
- 239000012798 spherical particle Substances 0.000 description 2
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical group C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- 241000309551 Arthraxon hispidus Species 0.000 description 1
- 208000018084 Bone neoplasm Diseases 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- 206010063560 Excessive granulation tissue Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000003076 Osteolysis Diseases 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 229910004283 SiO 4 Inorganic materials 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 229910052586 apatite Inorganic materials 0.000 description 1
- 239000012237 artificial material Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000002449 bone cell Anatomy 0.000 description 1
- 229940043430 calcium compound Drugs 0.000 description 1
- 150000001674 calcium compounds Chemical class 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- 229930008380 camphor Natural products 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 210000003275 diaphysis Anatomy 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 238000010304 firing Methods 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 210000001126 granulation tissue Anatomy 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000020169 heat generation Effects 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000000462 isostatic pressing Methods 0.000 description 1
- 208000029791 lytic metastatic bone lesion Diseases 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 238000001000 micrograph Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 210000002997 osteoclast Anatomy 0.000 description 1
- 230000002188 osteogenic effect Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000003980 solgel method Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Porous Artificial Stone Or Porous Ceramic Products (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58247226A JPS60142857A (ja) | 1983-12-29 | 1983-12-29 | 骨セメント組成物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58247226A JPS60142857A (ja) | 1983-12-29 | 1983-12-29 | 骨セメント組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60142857A JPS60142857A (ja) | 1985-07-29 |
| JPH0359703B2 true JPH0359703B2 (no) | 1991-09-11 |
Family
ID=17160326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58247226A Granted JPS60142857A (ja) | 1983-12-29 | 1983-12-29 | 骨セメント組成物 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS60142857A (no) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6179464A (ja) * | 1984-09-25 | 1986-04-23 | ティーディーケイ株式会社 | 人工骨材料用組成物 |
| DE3613213A1 (de) * | 1986-04-18 | 1987-10-22 | Merck Patent Gmbh | Tricalciumphosphat fuer implantationsmaterialien |
| JPH0722596B2 (ja) * | 1986-10-02 | 1995-03-15 | ティーディーケイ株式会社 | ブロツク状人工骨 |
| JP2558262B2 (ja) * | 1986-11-04 | 1996-11-27 | 住友大阪セメント 株式会社 | 人工関節固定材料 |
| JPS63125258A (ja) * | 1986-11-14 | 1988-05-28 | 三菱マテリアル株式会社 | 骨欠損部、空隙部及び吸収部充てん材 |
| JP2501213B2 (ja) * | 1987-07-27 | 1996-05-29 | 住友大阪セメント株式会社 | 骨接着剤 |
| JP2539501B2 (ja) * | 1988-10-19 | 1996-10-02 | 株式会社神戸製鋼所 | 燐酸カルシウム系化合物成形体およびその製造方法 |
| JP2694372B2 (ja) * | 1988-12-12 | 1997-12-24 | ウロプラスティ，インコーポレイテッド | 微小移植物質 |
| JP2725387B2 (ja) * | 1989-07-12 | 1998-03-11 | 三菱マテリアル株式会社 | 骨欠損部及び骨空隙部充てん材 |
| JPH03191963A (ja) * | 1989-12-22 | 1991-08-21 | Mitsubishi Materials Corp | リン酸カルシウム質多孔体骨補填材 |
| JPH0838589A (ja) * | 1995-06-21 | 1996-02-13 | Sumitomo Osaka Cement Co Ltd | 人工関節固定材料 |
| MY133943A (en) | 2000-08-22 | 2007-11-30 | Synthes Gmbh | Bone replacement material |
| JP4070951B2 (ja) * | 2000-12-07 | 2008-04-02 | ペンタックス株式会社 | 多孔質リン酸カルシウム系セラミックス焼結体の製造方法 |
| US6949251B2 (en) * | 2001-03-02 | 2005-09-27 | Stryker Corporation | Porous β-tricalcium phosphate granules for regeneration of bone tissue |
| CA2535188C (en) | 2003-08-08 | 2011-11-01 | Synthes Gmbh | Method to impregnate a porous bone replacement material |
| DE102004016065B3 (de) * | 2004-03-30 | 2005-06-09 | Zlb Behring Gmbh | Knochenersatzmittel |
| KR101161898B1 (ko) | 2004-06-03 | 2012-07-09 | 신세스 게엠바하 | 다공성의 뼈 대체물질을 주입하는 장치 |
| US8641667B2 (en) | 2005-10-20 | 2014-02-04 | DePuy Synthes Products, LLC | Perfusion device and method |
| WO2011143226A1 (en) | 2010-05-11 | 2011-11-17 | Howmedica Osteonics Corp. | Organophosphorous, multivalent metal compounds, & polymer adhesive interpenetrating network compositions & methods |
| EP3338815A1 (en) * | 2016-12-23 | 2018-06-27 | Sunstar Suisse SA | Bone graft substitute |
-
1983
- 1983-12-29 JP JP58247226A patent/JPS60142857A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS60142857A (ja) | 1985-07-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EXPY | Cancellation because of completion of term |