JPH0358326B2 - - Google Patents

Description

[Detailed description of the invention]

[Industrial Field of Application] The present invention relates to a composition with excellent storage stability containing hydroquinone-β-D-glucose and one or more kinds of vitamin E, and relates to a composition for use in cosmetics,
The aim is to provide external skin preparations that are useful in the fields of pharmaceuticals and quasi-drugs. [Conventional technology] Although there are some points that are unclear about the mechanism by which skin spots occur, in general, melanin pigments are formed due to hormonal abnormalities or stimulation of ultraviolet rays from sunlight, and this is caused by the formation of melanin within the skin. It is thought that it is abnormally deposited. To treat such age spots, oral or external preparations containing substances that inhibit melanin production, such as vitamin C, glutathione, cysteine, or hydroquinone, are used. However, vitamin C, glutathione, and cysteine have problems with stability and have strong off-odors, making it difficult to formulate them into formulations. They also have the disadvantage that the onset of their effects is extremely slow. Furthermore, although hydroquinone has been shown to be effective, its use is generally restricted due to its sensitizing properties. The present inventors have been studying substances with whitening effects for many years, and found that a specific hydroquinone glycoside has an excellent whitening effect, has a high stability,
They found that the product was safe and immediately filed a patent application (Japanese Patent Application No. 164815-1981). [Problems to be Solved by the Invention] As a result of subsequent studies by the present inventors, it was found that the above-mentioned hydroquinone glycoside gradually changes color when stored for a long period of time under harsh conditions. . This tendency is strong when it is blended into the base of cosmetics, pharmaceuticals, etc. In view of the above circumstances, the present inventors conducted repeated studies with the aim of stably incorporating these hydroquinone glycosides into the system, and as a result, they discovered that vitamin E exhibits excellent effects, and the present invention I was able to complete it. [Means for solving the problems] That is, the present invention provides hydroquinone-β-D-
The present invention provides an external skin preparation characterized by containing 0.001 to 1 part by weight of vitamin E based on 1 part by weight of glucose and hydroquinone-β-D-glucose. The present invention will be explained in detail below. Hydroquinone-β-D- used in the present invention
Glucose, whose common name is arbutin, is a product in which D-glucose is β-bonded to hydroquinone. The blending amount of hydroquinone-β-D-glucose is 0.1 to 30% by weight, preferably 6 to 20% by weight of the total amount of the skin external preparation, and the effect of adding vitamin E is remarkable when it is blended at 6% by weight or more. It is. Another essential component of the present invention is vitamin E. Specific examples include α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, tocopherol acetate, and tocopherol nicotinate. In the present invention, one or more of these may be selected and used. These vitamin E types may be of natural origin or synthetic products. When naturally-derived vitamin E (d-α-tocopherol) is used, either crude vitamin E or a purified product may be used, but the tocopherol content must be within the following range, so it is desirable to have a high tocopherol content. In addition to tocopherols, for example, triglycerides, lecithin, vitamins K, vitamins A, ubiquinone, and the like may be contained. The blending amount is 0.01 to 2% by weight of the total amount of the skin external preparation.
The amount is preferably 0.05 to 0.2% by weight, and a remarkable effect is exhibited at 0.001 to 1 part by weight per 1 part by weight of hydroquinone-β-D-glucose. External skin preparations that can contain hydroquinone-β-D-glucose and vitamin E include the usual external skin preparations, such as aqueous solutions, solubilized systems, emulsified systems, powder dispersion systems, water-oil two-layer systems, and water-oil systems. -Oil-Powder 3
It is a wide range of bases such as layered products, and can be used in basic cosmetics such as lotions, milky lotions, creams, and packs.
In addition to cosmetics such as makeup cosmetics such as lipsticks and foundations, and hair cosmetics such as shampoos, conditioners, and hair tonics, our products range from pharmaceuticals to quasi-drugs. The skin external preparation of the present invention may contain, as necessary, a humectant, a thickener, an oil, a preservative, an emulsifier, an antioxidant, a sequestering agent, an ultraviolet absorber, and the like, within a range that does not impair the effects of the present invention. Powders, drugs, colorants, fragrances, etc. can be added. [Effects of the Invention] The external skin preparation of the present invention contains hydroquinone-β-D-glucose, which is useful as a whitening agent, and has good stability without discoloration over time. [Example] Next, the present invention will be explained in more detail with reference to Examples. The blending amount is in weight%. Examples 1 to 3, Comparative Example 1

[Table] In Table 1, the base is the following lotion, and the degree of discoloration is the result of the lotion after storage at 50°C for 1 month, as determined by the following criteria. (Base) Ethanol 13.0 1,3-butylene glycol 10.0 POE (polyoxyethylene, same below, 15 mol)
Oleyl ether 1.0 Ethylparaben 0.1 Fragrance 0.05 Purified water Residual (degree of discoloration) ◎ No discoloration ○ Slight discoloration △ Considerable discoloration × Example with significant discoloration 4 Night cream A Setanol 4.0 Vaseline 7.0 Squalane 21.0 Stearic acid monoglyceride 2.2 POE (20) Sorbitan monostearate 2.8 Isopropyl myristate 6.0 β-tocopherol 1.0 Ethylparaben 0.3 Fragrance 0.2 B Propylene glycol 10.0 1,3-butylene glycol 5.0 Arbutin 1.0 Purified water Remainder (manufacturing method) Components of the oil phase belonging to A The components of the aqueous phase belonging to B are separately heated and dissolved,
The oil phase was mixed into the water phase and emulsified, and the mixture was cooled to room temperature to obtain a cream. Example 5 Foundation A Setanol 3.5 Deodorized lanolin 4.0 Jojoba oil 5.0 Vaseline 2.0 Squalane 6.0 Stearic acid monoglyceride 2.5 Tocopheryl acetate 0.05 POE (60) Hydrogenated castor oil 1.5 POE (25) Cetyl ether 1.0 Fragrance 0.2 B Glycerin 3.0 Pro Pyrene glycol 8.0 Mixed powder 12.0 Arbutin 0.5 Purified water Heat and dissolve the remaining oil phase components belonging to (manufacturing method) A. Separately, the components of the aqueous phase belonging to B, excluding the blended powder, are heated and dissolved, and the blended powder is dispersed therein. The oil phase was mixed into the water phase, emulsified, and cooled to room temperature to obtain a foundation cream. Example 6 Emulsion A Stearic acid 2.5 Setanol 1.5 Vaseline 5.0 Liquid paraffin 10.0 Tocopheryl acetate 0.1 POE (10) oleate 2.0 Propyl paraben 0.1 Fragrance 0.2 B Polyethylene glycol 1500 3.0 Triethanolamine 1.0 Arbutin 1.0 Hydroquinone-β-D-arabi North 0.1 Purified water Residual (manufacturing method) Same as Example 4. Example 7 Water-absorbing ointment vaseline 40.0 Stearyl alcohol 15.0 Mokuro 15.0 POE (10) oleate 0.25 Stearic acid monoglyceride 0.25 α-tocopherol 1.0 Arbutin 1.0 Purified water Remaining material (manufacturing method) according to Example 4. Example 8 Toner lotion ethanol 25.0 Propylene glycol 10.0 POE (15) oleyl ether 1.0 Tocopherol acetate 0.2 Arbutin 15.0 Citric acid 0.05 Sodium citrate 0.1 Ethylparaben 0.1 Fragrance 0.05 Purified water Residue (manufacturing method) as in Example 1. Examples 4 to 8 all had good stability over time and were excellent in usability and safety.

Claims (1)

[Claims] 1. A skin external preparation characterized by containing hydroquinone-β-D-glucose and 0.001 to 1 part by weight of vitamin E based on 1 part by weight of hydroquinone-β-D-glucose.