JPH03501084A - Vp7をコードするヒトロタウイルス血清型4遺伝子9の分子クローニング、糖タンパク質特異的主要外部カプシド中和及びワクチンに使用するためのvp7及びそのフラグメントの発現 - Google Patents
Vp7をコードするヒトロタウイルス血清型4遺伝子9の分子クローニング、糖タンパク質特異的主要外部カプシド中和及びワクチンに使用するためのvp7及びそのフラグメントの発現Info
- Publication number
- JPH03501084A JPH03501084A JP63506760A JP50676088A JPH03501084A JP H03501084 A JPH03501084 A JP H03501084A JP 63506760 A JP63506760 A JP 63506760A JP 50676088 A JP50676088 A JP 50676088A JP H03501084 A JPH03501084 A JP H03501084A
- Authority
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- Prior art keywords
- gene
- serotype
- rotavirus
- protein
- human rotavirus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12311—Rotavirus, e.g. rotavirus A
- C12N2720/12322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
Claims (14)
- 1.ヒトロタウイルス血清型4のVP7タンパク質のすべて又は一部をコードす る単離された遺伝子。
- 2.一本鎖又は二本鎖DNA又はRNAの形で存在する請求の範囲第1項記載の 遺伝子。
- 3.第1図のヌクレオチド配列に対応するヌクレオチド配列又はその一部又はサ ブユニットを有する請求の範囲第2項記載の遺伝子。
- 4.第1図の1又は複数のA,B、及びC領域を含む、請求の範囲第3項記載の 遺伝子の一部又はサブユニット。
- 5.請求の範囲第1〜4のいづれか1項記載の遺伝子を含むDNAトランスファ ーベクター。
- 6.プラスミド又はファージDNAである請求の範囲第4項記載のDNAトラン スファーベクター。
- 7.請求の範囲第5又は6項記載のDNAトランスファーベクターを含む宿主細 胞。
- 8.ヒトロタウイルス血清型4のVP7タンパク質のすべて又は一部が、細胞表 面上で又はその表面に関連して発現される請求の範囲第7項記載の宿主細胞。
- 9.請求の範囲第8項記載の宿主細胞を含んで成る経口ワクチン。
- 10.ヒトロタウイルス血清型4のVP7タンパク質のペプチド配列のすべて又 は一部を含むポリペプチド。
- 11.第1図のペプチド配列のすべて又は一部に対応するペプチド配列を有する 請求の範囲第11項記載のポリペプチド。
- 12.第1図の領域A,B及びCの少なくとも1つの領域を含む請求の範囲第1 1項記載のポリペプチド。
- 13.キャリヤー又は賦形剤と共に請求の範囲10〜12のいづれか1項記載の ポリペプチドを含んで成るワクチン。
- 14.ロタウイルスサンプル中の血清型4ヒトロタウイルスの存在を検出するた めの方法であって、第1図のA,B又はC領域の少なくとも1つの領域に対応し 又はそれに相補的なラベルされた核酸プローブにより前記ロタウイルスサンプル の核酸をハイブリダイズし、そして前記ロタウイルスサンプルにおけるロタウイ ルス核酸への前記核酸プローブの結合が生じているかいなかを検出することを含 んで成る方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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AU3643 | 1987-08-10 | ||
AUPI364387 | 1987-08-10 |
Publications (2)
Publication Number | Publication Date |
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JPH03501084A true JPH03501084A (ja) | 1991-03-14 |
JP3055687B2 JP3055687B2 (ja) | 2000-06-26 |
Family
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Application Number | Title | Priority Date | Filing Date |
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JP63506760A Expired - Lifetime JP3055687B2 (ja) | 1987-08-10 | 1988-08-10 | Vp7をコードするヒトロタウイルス血清型4遺伝子9の分子クローニング、糖タンパク質特異的主要外部カプシド中和及びワクチンに使用するためのvp7及びそのフラグメントの発現 |
Country Status (5)
Country | Link |
---|---|
US (2) | US5332658A (ja) |
EP (1) | EP0402354A4 (ja) |
JP (1) | JP3055687B2 (ja) |
CA (1) | CA1340876C (ja) |
WO (1) | WO1989001514A1 (ja) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5626851A (en) * | 1987-11-30 | 1997-05-06 | The Wistar Institute Of Anatomy And Biology | Rotavirus reassortant vaccine |
US5612487A (en) * | 1991-08-26 | 1997-03-18 | Edible Vaccines, Inc. | Anti-viral vaccines expressed in plants |
US6034298A (en) * | 1991-08-26 | 2000-03-07 | Prodigene, Inc. | Vaccines expressed in plants |
US5484719A (en) | 1991-08-26 | 1996-01-16 | Edible Vaccines, Inc. | Vaccines produced and administered through edible plants |
US5643578A (en) * | 1992-03-23 | 1997-07-01 | University Of Massachusetts Medical Center | Immunization by inoculation of DNA transcription unit |
CA2232023A1 (en) * | 1995-09-15 | 1997-03-20 | John A. Howard | Expression cassettes and methods for delivery of animal vaccines |
EP0977874B1 (en) * | 1997-04-18 | 2005-11-09 | Gesellschaft für biotechnologische Forschung mbH (GBF) | Attenuated salmonella strain used as a vehicle for oral immunization |
US6589529B1 (en) * | 1998-10-30 | 2003-07-08 | Children's Hospital Medical Center | Rotavirus subunit vaccine |
AU2004203804B2 (en) * | 1998-10-30 | 2007-01-25 | Children's Hospital Medical Center | Rotavirus subunit vaccine |
KR101502619B1 (ko) * | 2007-03-29 | 2015-03-16 | 한국엠에스디 유한회사 | 인간로타바이러스의 vp7 유전자 및 이에 특이적인프라이머 또는 프로브를 포함하는 인간로타바이러스 감염증진단용 조성물 |
UA103751C2 (ru) | 2007-07-27 | 2013-11-25 | Имматикс Биотекнолоджис Гмбх | Иммуногенный пептид для иммунотерапии |
WO2015004158A1 (en) | 2013-07-08 | 2015-01-15 | Novartis Ag | Rotavirus particles with chimeric surface proteins |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55104887A (en) * | 1978-12-22 | 1980-08-11 | Biogen Nv | Rearranged dna molecule and method |
JPS6226300A (ja) * | 1984-10-10 | 1987-02-04 | セントコ−・インコ−ポレ−テツド | Htlv−3dnaのクロ−ニングおよび発現 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
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CA1339735C (en) * | 1984-04-27 | 1998-03-17 | Ian Hamilton Holmes. | Cloning and sequencing of the major outer capsid gylcoprotein gene of a human rotavirus |
US4626524A (en) * | 1984-08-30 | 1986-12-02 | The General Hospital Corporation | Antiviral peptides |
US4853333A (en) * | 1985-07-26 | 1989-08-01 | American Home Products Corporation | Production of rotavirus in yeast |
CA1331355C (en) * | 1986-04-21 | 1994-08-09 | Bioenterprises Pty. Ltd | Immunopotentation |
US5186933A (en) * | 1986-12-30 | 1993-02-16 | Baylor College Of Medicine | Synthesis and immunogenicity of rotavirus genes using a baculovirus expression system |
-
1988
- 1988-08-10 EP EP19880907178 patent/EP0402354A4/en not_active Withdrawn
- 1988-08-10 CA CA000574292A patent/CA1340876C/en not_active Expired - Fee Related
- 1988-08-10 WO PCT/AU1988/000298 patent/WO1989001514A1/en not_active Application Discontinuation
- 1988-08-10 JP JP63506760A patent/JP3055687B2/ja not_active Expired - Lifetime
-
1992
- 1992-06-16 US US07/899,216 patent/US5332658A/en not_active Expired - Lifetime
-
1994
- 1994-07-25 US US08/280,016 patent/US5672684A/en not_active Expired - Lifetime
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55104887A (en) * | 1978-12-22 | 1980-08-11 | Biogen Nv | Rearranged dna molecule and method |
JPS6226300A (ja) * | 1984-10-10 | 1987-02-04 | セントコ−・インコ−ポレ−テツド | Htlv−3dnaのクロ−ニングおよび発現 |
Also Published As
Publication number | Publication date |
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US5672684A (en) | 1997-09-30 |
EP0402354A1 (en) | 1990-12-19 |
JP3055687B2 (ja) | 2000-06-26 |
US5332658A (en) | 1994-07-26 |
CA1340876C (en) | 2000-01-18 |
WO1989001514A1 (en) | 1989-02-23 |
EP0402354A4 (en) | 1991-03-20 |
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