JPH0261923B2 - - Google Patents
Info
- Publication number
- JPH0261923B2 JPH0261923B2 JP58126498A JP12649883A JPH0261923B2 JP H0261923 B2 JPH0261923 B2 JP H0261923B2 JP 58126498 A JP58126498 A JP 58126498A JP 12649883 A JP12649883 A JP 12649883A JP H0261923 B2 JPH0261923 B2 JP H0261923B2
- Authority
- JP
- Japan
- Prior art keywords
- compound
- reaction
- group
- acid
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 claims description 122
- 125000000217 alkyl group Chemical group 0.000 claims description 43
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical group C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 claims description 34
- 125000001424 substituent group Chemical group 0.000 claims description 34
- 125000005843 halogen group Chemical group 0.000 claims description 23
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 23
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 20
- 125000003545 alkoxy group Chemical group 0.000 claims description 17
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 14
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 12
- 239000003699 antiulcer agent Substances 0.000 claims description 9
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 8
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 claims description 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 7
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 6
- 125000003342 alkenyl group Chemical group 0.000 claims description 5
- 125000000304 alkynyl group Chemical group 0.000 claims description 5
- 125000003277 amino group Chemical group 0.000 claims description 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 5
- 239000004480 active ingredient Substances 0.000 claims description 4
- 125000003282 alkyl amino group Chemical group 0.000 claims description 4
- 125000002947 alkylene group Chemical group 0.000 claims description 4
- 125000005606 carbostyryl group Chemical group 0.000 claims description 4
- 125000002541 furyl group Chemical group 0.000 claims description 2
- 125000000623 heterocyclic group Chemical group 0.000 claims description 2
- 125000004076 pyridyl group Chemical group 0.000 claims description 2
- 238000006467 substitution reaction Methods 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 description 202
- -1 1-methylallyl Chemical group 0.000 description 133
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 129
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 91
- 239000002904 solvent Substances 0.000 description 89
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 84
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 82
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 77
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 70
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 68
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 67
- 239000013078 crystal Substances 0.000 description 62
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 61
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 58
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 54
- 235000019441 ethanol Nutrition 0.000 description 54
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 53
- 238000000034 method Methods 0.000 description 52
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 51
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 48
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 46
- 238000002844 melting Methods 0.000 description 45
- 230000008018 melting Effects 0.000 description 45
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 44
- 239000000243 solution Substances 0.000 description 44
- 238000003756 stirring Methods 0.000 description 44
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 38
- 239000003795 chemical substances by application Substances 0.000 description 37
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 36
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 35
- GVOISEJVFFIGQE-YCZSINBZSA-N n-[(1r,2s,5r)-5-[methyl(propan-2-yl)amino]-2-[(3s)-2-oxo-3-[[6-(trifluoromethyl)quinazolin-4-yl]amino]pyrrolidin-1-yl]cyclohexyl]acetamide Chemical compound CC(=O)N[C@@H]1C[C@H](N(C)C(C)C)CC[C@@H]1N1C(=O)[C@@H](NC=2C3=CC(=CC=C3N=CN=2)C(F)(F)F)CC1 GVOISEJVFFIGQE-YCZSINBZSA-N 0.000 description 35
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 35
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 33
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 32
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 30
- 150000007514 bases Chemical class 0.000 description 30
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 28
- 150000002170 ethers Chemical class 0.000 description 28
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 26
- 235000011121 sodium hydroxide Nutrition 0.000 description 26
- 239000003054 catalyst Substances 0.000 description 25
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 24
- 239000002253 acid Substances 0.000 description 24
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 23
- PHDIJLFSKNMCMI-ITGJKDDRSA-N (3R,4S,5R,6R)-6-(hydroxymethyl)-4-(8-quinolin-6-yloxyoctoxy)oxane-2,3,5-triol Chemical compound OC[C@@H]1[C@H]([C@@H]([C@H](C(O1)O)O)OCCCCCCCCOC=1C=C2C=CC=NC2=CC=1)O PHDIJLFSKNMCMI-ITGJKDDRSA-N 0.000 description 22
- SJRJJKPEHAURKC-UHFFFAOYSA-N N-Methylmorpholine Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 21
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 21
- 150000001298 alcohols Chemical class 0.000 description 20
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 19
- BEXZJJQVPWJPOA-VOTSOKGWSA-N [(e)-hept-2-enyl] 6-methyl-4-(4-nitrophenyl)-2-oxo-3,4-dihydro-1h-pyrimidine-5-carboxylate Chemical compound CCCC\C=C\COC(=O)C1=C(C)NC(=O)NC1C1=CC=C([N+]([O-])=O)C=C1 BEXZJJQVPWJPOA-VOTSOKGWSA-N 0.000 description 19
- 229910000027 potassium carbonate Inorganic materials 0.000 description 19
- 235000011181 potassium carbonates Nutrition 0.000 description 19
- 239000008096 xylene Substances 0.000 description 19
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 18
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 18
- 239000000843 powder Substances 0.000 description 18
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 17
- 239000000203 mixture Substances 0.000 description 17
- 238000006722 reduction reaction Methods 0.000 description 17
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 description 16
- 238000006460 hydrolysis reaction Methods 0.000 description 16
- 235000011118 potassium hydroxide Nutrition 0.000 description 16
- 229910000029 sodium carbonate Inorganic materials 0.000 description 16
- 235000017550 sodium carbonate Nutrition 0.000 description 16
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 16
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 15
- 125000004432 carbon atom Chemical group C* 0.000 description 15
- 230000002140 halogenating effect Effects 0.000 description 15
- GNOIPBMMFNIUFM-UHFFFAOYSA-N hexamethylphosphoric triamide Chemical compound CN(C)P(=O)(N(C)C)N(C)C GNOIPBMMFNIUFM-UHFFFAOYSA-N 0.000 description 15
- 239000007858 starting material Substances 0.000 description 15
- 150000007513 acids Chemical class 0.000 description 13
- 210000000988 bone and bone Anatomy 0.000 description 13
- 238000001816 cooling Methods 0.000 description 13
- 239000012442 inert solvent Substances 0.000 description 13
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 12
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 12
- 238000010531 catalytic reduction reaction Methods 0.000 description 12
- 150000002148 esters Chemical class 0.000 description 12
- 239000002798 polar solvent Substances 0.000 description 12
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 12
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 12
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 11
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 11
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 11
- 239000003638 chemical reducing agent Substances 0.000 description 11
- 238000000354 decomposition reaction Methods 0.000 description 11
- 235000015497 potassium bicarbonate Nutrition 0.000 description 11
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 11
- 239000011736 potassium bicarbonate Substances 0.000 description 11
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 description 10
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 10
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 10
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 10
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 10
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 description 10
- 150000008065 acid anhydrides Chemical class 0.000 description 10
- 229910052783 alkali metal Inorganic materials 0.000 description 10
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 10
- 150000007529 inorganic bases Chemical class 0.000 description 10
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 description 10
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 10
- 238000001953 recrystallisation Methods 0.000 description 10
- 235000002639 sodium chloride Nutrition 0.000 description 10
- 229910000104 sodium hydride Inorganic materials 0.000 description 10
- 239000012312 sodium hydride Substances 0.000 description 10
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 10
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 10
- HBENZIXOGRCSQN-VQWWACLZSA-N (1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(2S)-2-hydroxy-3,3-dimethylpentan-2-yl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol Chemical compound N1([C@@H]2CC=3C4=C(C(=CC=3)O)O[C@H]3[C@@]5(OC)CC[C@@]2([C@@]43CC1)C[C@@H]5[C@](C)(O)C(C)(C)CC)CC1CC1 HBENZIXOGRCSQN-VQWWACLZSA-N 0.000 description 9
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 9
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 9
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 9
- 150000008282 halocarbons Chemical class 0.000 description 9
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 9
- 235000019260 propionic acid Nutrition 0.000 description 9
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 9
- 238000010992 reflux Methods 0.000 description 9
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 9
- 235000017557 sodium bicarbonate Nutrition 0.000 description 9
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 9
- ONBQEOIKXPHGMB-VBSBHUPXSA-N 1-[2-[(2s,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)propan-1-one Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=CC(O)=C1C(=O)CCC1=CC=C(O)C=C1 ONBQEOIKXPHGMB-VBSBHUPXSA-N 0.000 description 8
- 150000001340 alkali metals Chemical class 0.000 description 8
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 description 8
- 229940126142 compound 16 Drugs 0.000 description 8
- 229940125782 compound 2 Drugs 0.000 description 8
- SBZXBUIDTXKZTM-UHFFFAOYSA-N diglyme Chemical compound COCCOCCOC SBZXBUIDTXKZTM-UHFFFAOYSA-N 0.000 description 8
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 8
- 238000010438 heat treatment Methods 0.000 description 8
- 239000012046 mixed solvent Substances 0.000 description 8
- UNILWMWFPHPYOR-KXEYIPSPSA-M 1-[6-[2-[3-[3-[3-[2-[2-[3-[[2-[2-[[(2r)-1-[[2-[[(2r)-1-[3-[2-[2-[3-[[2-(2-amino-2-oxoethoxy)acetyl]amino]propoxy]ethoxy]ethoxy]propylamino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-[(2r)-2,3-di(hexadecanoyloxy)propyl]sulfanyl-1-oxopropan-2-yl Chemical compound O=C1C(SCCC(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](CSC[C@@H](COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NCC(=O)N[C@H](CO)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(N)=O)CC(=O)N1CCNC(=O)CCCCCN\1C2=CC=C(S([O-])(=O)=O)C=C2CC/1=C/C=C/C=C/C1=[N+](CC)C2=CC=C(S([O-])(=O)=O)C=C2C1 UNILWMWFPHPYOR-KXEYIPSPSA-M 0.000 description 7
- WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Natural products OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 7
- 229920002472 Starch Polymers 0.000 description 7
- 238000005917 acylation reaction Methods 0.000 description 7
- 238000005886 esterification reaction Methods 0.000 description 7
- 230000007062 hydrolysis Effects 0.000 description 7
- 239000012280 lithium aluminium hydride Substances 0.000 description 7
- 150000007522 mineralic acids Chemical class 0.000 description 7
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 7
- 230000035484 reaction time Effects 0.000 description 7
- 239000008107 starch Substances 0.000 description 7
- 235000019698 starch Nutrition 0.000 description 7
- 239000003826 tablet Substances 0.000 description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 6
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 6
- JLTDJTHDQAWBAV-UHFFFAOYSA-N N,N-dimethylaniline Chemical compound CN(C)C1=CC=CC=C1 JLTDJTHDQAWBAV-UHFFFAOYSA-N 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 description 6
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 6
- WTEOIRVLGSZEPR-UHFFFAOYSA-N boron trifluoride Chemical compound FB(F)F WTEOIRVLGSZEPR-UHFFFAOYSA-N 0.000 description 6
- 229940125898 compound 5 Drugs 0.000 description 6
- 235000008504 concentrate Nutrition 0.000 description 6
- 239000012141 concentrate Substances 0.000 description 6
- 239000005457 ice water Substances 0.000 description 6
- 229910052751 metal Inorganic materials 0.000 description 6
- 239000002184 metal Substances 0.000 description 6
- 150000007530 organic bases Chemical class 0.000 description 6
- 239000002994 raw material Substances 0.000 description 6
- ODZPKZBBUMBTMG-UHFFFAOYSA-N sodium amide Chemical compound [NH2-].[Na+] ODZPKZBBUMBTMG-UHFFFAOYSA-N 0.000 description 6
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 5
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 5
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 5
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 5
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 5
- 239000002841 Lewis acid Substances 0.000 description 5
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 5
- 208000025865 Ulcer Diseases 0.000 description 5
- 230000002378 acidificating effect Effects 0.000 description 5
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 5
- 235000011114 ammonium hydroxide Nutrition 0.000 description 5
- 239000012024 dehydrating agentsâ Substances 0.000 description 5
- 239000008103 glucose Substances 0.000 description 5
- 238000005984 hydrogenation reaction Methods 0.000 description 5
- 229910052500 inorganic mineral Inorganic materials 0.000 description 5
- 150000007517 lewis acids Chemical class 0.000 description 5
- 235000010755 mineral Nutrition 0.000 description 5
- 239000011707 mineral Substances 0.000 description 5
- 229940086066 potassium hydrogencarbonate Drugs 0.000 description 5
- 239000011541 reaction mixture Substances 0.000 description 5
- 238000010898 silica gel chromatography Methods 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 5
- 231100000397 ulcer Toxicity 0.000 description 5
- GHYOCDFICYLMRF-UTIIJYGPSA-N (2S,3R)-N-[(2S)-3-(cyclopenten-1-yl)-1-[(2R)-2-methyloxiran-2-yl]-1-oxopropan-2-yl]-3-hydroxy-3-(4-methoxyphenyl)-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]propanoyl]amino]propanamide Chemical compound C1(=CCCC1)C[C@@H](C(=O)[C@@]1(OC1)C)NC([C@H]([C@@H](C1=CC=C(C=C1)OC)O)NC([C@H](C)NC(CN1CCOCC1)=O)=O)=O GHYOCDFICYLMRF-UTIIJYGPSA-N 0.000 description 4
- ZXSQEZNORDWBGZ-UHFFFAOYSA-N 1,3-dihydropyrrolo[2,3-b]pyridin-2-one Chemical compound C1=CN=C2NC(=O)CC2=C1 ZXSQEZNORDWBGZ-UHFFFAOYSA-N 0.000 description 4
- RKIDDEGICSMIJA-UHFFFAOYSA-N 4-chlorobenzoyl chloride Chemical compound ClC(=O)C1=CC=C(Cl)C=C1 RKIDDEGICSMIJA-UHFFFAOYSA-N 0.000 description 4
- HIHOEGPXVVKJPP-JTQLQIEISA-N 5-fluoro-2-[[(1s)-1-(5-fluoropyridin-2-yl)ethyl]amino]-6-[(5-methyl-1h-pyrazol-3-yl)amino]pyridine-3-carbonitrile Chemical compound N([C@@H](C)C=1N=CC(F)=CC=1)C(C(=CC=1F)C#N)=NC=1NC=1C=C(C)NN=1 HIHOEGPXVVKJPP-JTQLQIEISA-N 0.000 description 4
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 4
- 239000005711 Benzoic acid Substances 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 4
- JRNVZBWKYDBUCA-UHFFFAOYSA-N N-chlorosuccinimide Chemical compound ClN1C(=O)CCC1=O JRNVZBWKYDBUCA-UHFFFAOYSA-N 0.000 description 4
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 4
- 239000007868 Raney catalyst Substances 0.000 description 4
- 229910000564 Raney nickel Inorganic materials 0.000 description 4
- NPXOKRUENSOPAO-UHFFFAOYSA-N Raney nickel Chemical compound [Al].[Ni] NPXOKRUENSOPAO-UHFFFAOYSA-N 0.000 description 4
- 238000003436 Schotten-Baumann reaction Methods 0.000 description 4
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 4
- 229910001516 alkali metal iodide Inorganic materials 0.000 description 4
- 239000002168 alkylating agent Substances 0.000 description 4
- 229940100198 alkylating agent Drugs 0.000 description 4
- 150000004982 aromatic amines Chemical group 0.000 description 4
- 239000002585 base Substances 0.000 description 4
- 235000010233 benzoic acid Nutrition 0.000 description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 4
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 4
- 229910052794 bromium Inorganic materials 0.000 description 4
- WORJEOGGNQDSOE-UHFFFAOYSA-N chloroform;methanol Chemical compound OC.ClC(Cl)Cl WORJEOGGNQDSOE-UHFFFAOYSA-N 0.000 description 4
- 229940125904 compound 1 Drugs 0.000 description 4
- 229940125773 compound 10 Drugs 0.000 description 4
- 229940125797 compound 12 Drugs 0.000 description 4
- 238000006356 dehydrogenation reaction Methods 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 description 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 4
- ZLVXBBHTMQJRSX-VMGNSXQWSA-N jdtic Chemical compound C1([C@]2(C)CCN(C[C@@H]2C)C[C@H](C(C)C)NC(=O)[C@@H]2NCC3=CC(O)=CC=C3C2)=CC=CC(O)=C1 ZLVXBBHTMQJRSX-VMGNSXQWSA-N 0.000 description 4
- 150000002576 ketones Chemical class 0.000 description 4
- 239000008101 lactose Substances 0.000 description 4
- 239000012452 mother liquor Substances 0.000 description 4
- 229910017604 nitric acid Inorganic materials 0.000 description 4
- LQNUZADURLCDLV-UHFFFAOYSA-N nitrobenzene Chemical compound [O-][N+](=O)C1=CC=CC=C1 LQNUZADURLCDLV-UHFFFAOYSA-N 0.000 description 4
- 150000007524 organic acids Chemical class 0.000 description 4
- 235000005985 organic acids Nutrition 0.000 description 4
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 4
- NTTOTNSKUYCDAV-UHFFFAOYSA-N potassium hydride Chemical compound [KH] NTTOTNSKUYCDAV-UHFFFAOYSA-N 0.000 description 4
- 229910000105 potassium hydride Inorganic materials 0.000 description 4
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 4
- LKZMBDSASOBTPN-UHFFFAOYSA-L silver carbonate Substances [Ag].[O-]C([O-])=O LKZMBDSASOBTPN-UHFFFAOYSA-L 0.000 description 4
- 229910001958 silver carbonate Inorganic materials 0.000 description 4
- 235000009518 sodium iodide Nutrition 0.000 description 4
- 229910052938 sodium sulfate Inorganic materials 0.000 description 4
- 235000011152 sodium sulphate Nutrition 0.000 description 4
- IMNIMPAHZVJRPE-UHFFFAOYSA-N triethylenediamine Chemical compound C1CN2CCN1CC2 IMNIMPAHZVJRPE-UHFFFAOYSA-N 0.000 description 4
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 4
- YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 4
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 4
- AOSZTAHDEDLTLQ-AZKQZHLXSA-N (1S,2S,4R,8S,9S,11S,12R,13S,19S)-6-[(3-chlorophenyl)methyl]-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-azapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one Chemical compound C([C@@H]1C[C@H]2[C@H]3[C@]([C@]4(C=CC(=O)C=C4[C@@H](F)C3)C)(F)[C@@H](O)C[C@@]2([C@@]1(C1)C(=O)CO)C)N1CC1=CC=CC(Cl)=C1 AOSZTAHDEDLTLQ-AZKQZHLXSA-N 0.000 description 3
- IUSARDYWEPUTPN-OZBXUNDUSA-N (2r)-n-[(2s,3r)-4-[[(4s)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-[3-(1,3-thiazol-2-yl)phenyl]butan-2-yl]-2-methoxypropanamide Chemical compound C([C@H](NC(=O)[C@@H](C)OC)[C@H](O)CN[C@@H]1C2=CC(CC(C)(C)C)=CN=C2OC2(CCC2)C1)C(C=1)=CC=CC=1C1=NC=CS1 IUSARDYWEPUTPN-OZBXUNDUSA-N 0.000 description 3
- RFFLAFLAYFXFSW-UHFFFAOYSA-N 1,2-dichlorobenzene Chemical compound ClC1=CC=CC=C1Cl RFFLAFLAYFXFSW-UHFFFAOYSA-N 0.000 description 3
- WZZBNLYBHUDSHF-DHLKQENFSA-N 1-[(3s,4s)-4-[8-(2-chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-hydroxyethanone Chemical compound CC1=NC2=CN=C3C=C(F)C(C=4C(=CC(OC=5N=CC=CN=5)=CC=4)Cl)=CC3=C2N1[C@H]1CCN(C(=O)CO)C[C@@H]1F WZZBNLYBHUDSHF-DHLKQENFSA-N 0.000 description 3
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical class CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 3
- XRHGYUZYPHTUJZ-UHFFFAOYSA-N 4-chlorobenzoic acid Chemical compound OC(=O)C1=CC=C(Cl)C=C1 XRHGYUZYPHTUJZ-UHFFFAOYSA-N 0.000 description 3
- MWVKLRSIDOXBSE-UHFFFAOYSA-N 5-(1-piperidin-4-ylpyrazol-4-yl)-3-(6-pyrrolidin-1-yl-1,3-benzoxazol-2-yl)pyridin-2-amine Chemical compound NC1=NC=C(C2=CN(N=C2)C2CCNCC2)C=C1C(OC1=C2)=NC1=CC=C2N1CCCC1 MWVKLRSIDOXBSE-UHFFFAOYSA-N 0.000 description 3
- 239000005995 Aluminium silicate Substances 0.000 description 3
- 229910015900 BF3 Inorganic materials 0.000 description 3
- DGJMHKMYSDYOFP-MRXNPFEDSA-N C=CC(N(CCC1)C[C@@H]1N1N=C(C2=CN(CC(C3=CC=CC=C3)(F)F)N=N2)C2=C(N)N=CN=C12)=O Chemical compound C=CC(N(CCC1)C[C@@H]1N1N=C(C2=CN(CC(C3=CC=CC=C3)(F)F)N=N2)C2=C(N)N=CN=C12)=O DGJMHKMYSDYOFP-MRXNPFEDSA-N 0.000 description 3
- 229940126657 Compound 17 Drugs 0.000 description 3
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- PCLIMKBDDGJMGD-UHFFFAOYSA-N N-bromosuccinimide Chemical compound BrN1C(=O)CCC1=O PCLIMKBDDGJMGD-UHFFFAOYSA-N 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 3
- 239000003377 acid catalyst Chemical class 0.000 description 3
- 230000010933 acylation Effects 0.000 description 3
- 229910000288 alkali metal carbonate Inorganic materials 0.000 description 3
- 150000008041 alkali metal carbonates Chemical class 0.000 description 3
- 235000012211 aluminium silicate Nutrition 0.000 description 3
- 150000001408 amides Chemical class 0.000 description 3
- XRWSZZJLZRKHHD-WVWIJVSJSA-N asunaprevir Chemical compound O=C([C@@H]1C[C@H](CN1C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)(C)C)OC1=NC=C(C2=CC=C(Cl)C=C21)OC)N[C@]1(C(=O)NS(=O)(=O)C2CC2)C[C@H]1C=C XRWSZZJLZRKHHD-WVWIJVSJSA-N 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 238000006664 bond formation reaction Methods 0.000 description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 description 3
- 235000010216 calcium carbonate Nutrition 0.000 description 3
- 239000000969 carrier Substances 0.000 description 3
- 229940126086 compound 21 Drugs 0.000 description 3
- 229940125961 compound 24 Drugs 0.000 description 3
- 229940125807 compound 37 Drugs 0.000 description 3
- 229940126540 compound 41 Drugs 0.000 description 3
- LGTLXDJOAJDFLR-UHFFFAOYSA-N diethyl chlorophosphate Chemical compound CCOP(Cl)(=O)OCC LGTLXDJOAJDFLR-UHFFFAOYSA-N 0.000 description 3
- 239000007884 disintegrant Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- ZHNUHDYFZUAESO-UHFFFAOYSA-N formamide Substances NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 3
- 150000003948 formamides Chemical class 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000000543 intermediate Substances 0.000 description 3
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 3
- SURQXAFEQWPFPV-UHFFFAOYSA-L iron(2+) sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Fe+2].[O-]S([O-])(=O)=O SURQXAFEQWPFPV-UHFFFAOYSA-L 0.000 description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
- 239000010410 layer Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- RENRQMCACQEWFC-UGKGYDQZSA-N lnp023 Chemical compound C1([C@H]2N(CC=3C=4C=CNC=4C(C)=CC=3OC)CC[C@@H](C2)OCC)=CC=C(C(O)=O)C=C1 RENRQMCACQEWFC-UGKGYDQZSA-N 0.000 description 3
- UKVIEHSSVKSQBA-UHFFFAOYSA-N methane;palladium Chemical compound C.[Pd] UKVIEHSSVKSQBA-UHFFFAOYSA-N 0.000 description 3
- 230000000802 nitrating effect Effects 0.000 description 3
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 229910052698 phosphorus Inorganic materials 0.000 description 3
- 239000011574 phosphorus Substances 0.000 description 3
- 239000006187 pill Substances 0.000 description 3
- 229910052697 platinum Inorganic materials 0.000 description 3
- 238000007363 ring formation reaction Methods 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical class O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 3
- 239000000829 suppository Substances 0.000 description 3
- 150000003512 tertiary amines Chemical class 0.000 description 3
- 229940124597 therapeutic agent Drugs 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- TXUICONDJPYNPY-UHFFFAOYSA-N (1,10,13-trimethyl-3-oxo-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl) heptanoate Chemical compound C1CC2CC(=O)C=C(C)C2(C)C2C1C1CCC(OC(=O)CCCCCC)C1(C)CC2 TXUICONDJPYNPY-UHFFFAOYSA-N 0.000 description 2
- ASGMFNBUXDJWJJ-JLCFBVMHSA-N (1R,3R)-3-[[3-bromo-1-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N,1-dimethylcyclopentane-1-carboxamide Chemical compound BrC1=NN(C2=NC(=NC=C21)N[C@H]1C[C@@](CC1)(C(=O)NC)C)C1=CC=C(C=C1)C=1SC(=NN=1)C ASGMFNBUXDJWJJ-JLCFBVMHSA-N 0.000 description 2
- GLGNXYJARSMNGJ-VKTIVEEGSA-N (1s,2s,3r,4r)-3-[[5-chloro-2-[(1-ethyl-6-methoxy-2-oxo-4,5-dihydro-3h-1-benzazepin-7-yl)amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide Chemical compound CCN1C(=O)CCCC2=C(OC)C(NC=3N=C(C(=CN=3)Cl)N[C@H]3[C@H]([C@@]4([H])C[C@@]3(C=C4)[H])C(N)=O)=CC=C21 GLGNXYJARSMNGJ-VKTIVEEGSA-N 0.000 description 2
- SZUVGFMDDVSKSI-WIFOCOSTSA-N (1s,2s,3s,5r)-1-(carboxymethyl)-3,5-bis[(4-phenoxyphenyl)methyl-propylcarbamoyl]cyclopentane-1,2-dicarboxylic acid Chemical compound O=C([C@@H]1[C@@H]([C@](CC(O)=O)([C@H](C(=O)N(CCC)CC=2C=CC(OC=3C=CC=CC=3)=CC=2)C1)C(O)=O)C(O)=O)N(CCC)CC(C=C1)=CC=C1OC1=CC=CC=C1 SZUVGFMDDVSKSI-WIFOCOSTSA-N 0.000 description 2
- YJLIKUSWRSEPSM-WGQQHEPDSA-N (2r,3r,4s,5r)-2-[6-amino-8-[(4-phenylphenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound C=1C=C(C=2C=CC=CC=2)C=CC=1CNC1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O YJLIKUSWRSEPSM-WGQQHEPDSA-N 0.000 description 2
- QFLWZFQWSBQYPS-AWRAUJHKSA-N (3S)-3-[[(2S)-2-[[(2S)-2-[5-[(3aS,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-[1-bis(4-chlorophenoxy)phosphorylbutylamino]-4-oxobutanoic acid Chemical compound CCCC(NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CCCCC1SC[C@@H]2NC(=O)N[C@H]12)C(C)C)P(=O)(Oc1ccc(Cl)cc1)Oc1ccc(Cl)cc1 QFLWZFQWSBQYPS-AWRAUJHKSA-N 0.000 description 2
- IWZSHWBGHQBIML-ZGGLMWTQSA-N (3S,8S,10R,13S,14S,17S)-17-isoquinolin-7-yl-N,N,10,13-tetramethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-amine Chemical compound CN(C)[C@H]1CC[C@]2(C)C3CC[C@@]4(C)[C@@H](CC[C@@H]4c4ccc5ccncc5c4)[C@@H]3CC=C2C1 IWZSHWBGHQBIML-ZGGLMWTQSA-N 0.000 description 2
- IGVKWAAPMVVTFX-BUHFOSPRSA-N (e)-octadec-5-en-7,9-diynoic acid Chemical compound CCCCCCCCC#CC#C\C=C\CCCC(O)=O IGVKWAAPMVVTFX-BUHFOSPRSA-N 0.000 description 2
- VAVHMEQFYYBAPR-ITWZMISCSA-N (e,3r,5s)-7-[4-(4-fluorophenyl)-1-phenyl-2-propan-2-ylpyrrol-3-yl]-3,5-dihydroxyhept-6-enoic acid Chemical compound CC(C)C1=C(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)C(C=2C=CC(F)=CC=2)=CN1C1=CC=CC=C1 VAVHMEQFYYBAPR-ITWZMISCSA-N 0.000 description 2
- OGFAWKRXZLGJSK-UHFFFAOYSA-N 1-(2,4-dihydroxyphenyl)-2-(4-nitrophenyl)ethanone Chemical compound OC1=CC(O)=CC=C1C(=O)CC1=CC=C([N+]([O-])=O)C=C1 OGFAWKRXZLGJSK-UHFFFAOYSA-N 0.000 description 2
- KQZLRWGGWXJPOS-NLFPWZOASA-N 1-[(1R)-1-(2,4-dichlorophenyl)ethyl]-6-[(4S,5R)-4-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-5-methylcyclohexen-1-yl]pyrazolo[3,4-b]pyrazine-3-carbonitrile Chemical compound ClC1=C(C=CC(=C1)Cl)[C@@H](C)N1N=C(C=2C1=NC(=CN=2)C1=CC[C@@H]([C@@H](C1)C)N1[C@@H](CCC1)CO)C#N KQZLRWGGWXJPOS-NLFPWZOASA-N 0.000 description 2
- PYRKKGOKRMZEIT-UHFFFAOYSA-N 2-[6-(2-cyclopropylethoxy)-9-(2-hydroxy-2-methylpropyl)-1h-phenanthro[9,10-d]imidazol-2-yl]-5-fluorobenzene-1,3-dicarbonitrile Chemical compound C1=C2C3=CC(CC(C)(O)C)=CC=C3C=3NC(C=4C(=CC(F)=CC=4C#N)C#N)=NC=3C2=CC=C1OCCC1CC1 PYRKKGOKRMZEIT-UHFFFAOYSA-N 0.000 description 2
- TVTJUIAKQFIXCE-HUKYDQBMSA-N 2-amino-9-[(2R,3S,4S,5R)-4-fluoro-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-prop-2-ynyl-1H-purine-6,8-dione Chemical compound NC=1NC(C=2N(C(N(C=2N=1)[C@@H]1O[C@@H]([C@H]([C@H]1O)F)CO)=O)CC#C)=O TVTJUIAKQFIXCE-HUKYDQBMSA-N 0.000 description 2
- FXWFZIRWWNPPOV-UHFFFAOYSA-N 2-aminobenzaldehyde Chemical compound NC1=CC=CC=C1C=O FXWFZIRWWNPPOV-UHFFFAOYSA-N 0.000 description 2
- UOIJHUIOTFDGNA-UHFFFAOYSA-N 2-chloro-3-(chloromethyl)quinoline Chemical compound C1=CC=C2N=C(Cl)C(CCl)=CC2=C1 UOIJHUIOTFDGNA-UHFFFAOYSA-N 0.000 description 2
- ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 description 2
- YOETUEMZNOLGDB-UHFFFAOYSA-N 2-methylpropyl carbonochloridate Chemical compound CC(C)COC(Cl)=O YOETUEMZNOLGDB-UHFFFAOYSA-N 0.000 description 2
- BSKHPKMHTQYZBB-UHFFFAOYSA-N 2-methylpyridine Chemical compound CC1=CC=CC=N1 BSKHPKMHTQYZBB-UHFFFAOYSA-N 0.000 description 2
- ISSLIOUBBBGYRY-UHFFFAOYSA-N 2-sulfanylidene-3H-1,3-benzoxazole-4-carboxamide Chemical compound O1C(NC=2C1=CC=CC=2C(=O)N)=S ISSLIOUBBBGYRY-UHFFFAOYSA-N 0.000 description 2
- YZMGOVZHTUYCIT-UHFFFAOYSA-N 3-(3-ethoxyprop-2-enoylamino)benzoic acid Chemical compound CCOC=CC(=O)NC1=CC=CC(C(O)=O)=C1 YZMGOVZHTUYCIT-UHFFFAOYSA-N 0.000 description 2
- SFMFACMIOWQIPR-UHFFFAOYSA-N 3-ethoxyprop-2-enoyl chloride Chemical compound CCOC=CC(Cl)=O SFMFACMIOWQIPR-UHFFFAOYSA-N 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- KCBAMQOKOLXLOX-BSZYMOERSA-N CC1=C(SC=N1)C2=CC=C(C=C2)[C@H](C)NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCCCCCCCNCCCONC(=O)C4=C(C(=C(C=C4)F)F)NC5=C(C=C(C=C5)I)F)O Chemical compound CC1=C(SC=N1)C2=CC=C(C=C2)[C@H](C)NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCCCCCCCNCCCONC(=O)C4=C(C(=C(C=C4)F)F)NC5=C(C=C(C=C5)I)F)O KCBAMQOKOLXLOX-BSZYMOERSA-N 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- VGCXGMAHQTYDJK-UHFFFAOYSA-N Chloroacetyl chloride Chemical compound ClCC(Cl)=O VGCXGMAHQTYDJK-UHFFFAOYSA-N 0.000 description 2
- 229940127007 Compound 39 Drugs 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 229920001543 Laminarin Polymers 0.000 description 2
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 2
- OKJIRPAQVSHGFK-UHFFFAOYSA-N N-acetylglycine Chemical compound CC(=O)NCC(O)=O OKJIRPAQVSHGFK-UHFFFAOYSA-N 0.000 description 2
- LPGDEHBASRKTDG-UHFFFAOYSA-N N-acetylisatin Chemical compound C1=CC=C2N(C(=O)C)C(=O)C(=O)C2=C1 LPGDEHBASRKTDG-UHFFFAOYSA-N 0.000 description 2
- FZERHIULMFGESH-UHFFFAOYSA-N N-phenylacetamide Chemical compound CC(=O)NC1=CC=CC=C1 FZERHIULMFGESH-UHFFFAOYSA-N 0.000 description 2
- OPFJDXRVMFKJJO-ZHHKINOHSA-N N-{[3-(2-benzamido-4-methyl-1,3-thiazol-5-yl)-pyrazol-5-yl]carbonyl}-G-dR-G-dD-dD-dD-NH2 Chemical compound S1C(C=2NN=C(C=2)C(=O)NCC(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(O)=O)C(N)=O)=C(C)N=C1NC(=O)C1=CC=CC=C1 OPFJDXRVMFKJJO-ZHHKINOHSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 229920001214 Polysorbate 60 Polymers 0.000 description 2
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 229910021626 Tin(II) chloride Inorganic materials 0.000 description 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- SPXSEZMVRJLHQG-XMMPIXPASA-N [(2R)-1-[[4-[(3-phenylmethoxyphenoxy)methyl]phenyl]methyl]pyrrolidin-2-yl]methanol Chemical compound C(C1=CC=CC=C1)OC=1C=C(OCC2=CC=C(CN3[C@H](CCC3)CO)C=C2)C=CC=1 SPXSEZMVRJLHQG-XMMPIXPASA-N 0.000 description 2
- LNUFLCYMSVYYNW-ZPJMAFJPSA-N [(2r,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6r)-6-[(2r,3r,4s,5r,6r)-6-[(2r,3r,4s,5r,6r)-6-[[(3s,5s,8r,9s,10s,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-3-yl]oxy]-4,5-disulfo Chemical compound O([C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1OS(O)(=O)=O)OS(O)(=O)=O)O[C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1OS(O)(=O)=O)OS(O)(=O)=O)O[C@@H]1[C@@H](COS(O)(=O)=O)O[C@H]([C@@H]([C@H]1OS(O)(=O)=O)OS(O)(=O)=O)O[C@@H]1C[C@@H]2CC[C@H]3[C@@H]4CC[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@H](C)CCCC(C)C)[C@H]1O[C@H](COS(O)(=O)=O)[C@@H](OS(O)(=O)=O)[C@H](OS(O)(=O)=O)[C@H]1OS(O)(=O)=O LNUFLCYMSVYYNW-ZPJMAFJPSA-N 0.000 description 2
- GHVZOJONCUEWAV-UHFFFAOYSA-N [K].CCO Chemical compound [K].CCO GHVZOJONCUEWAV-UHFFFAOYSA-N 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 235000010419 agar Nutrition 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 150000001350 alkyl halides Chemical class 0.000 description 2
- 238000005804 alkylation reaction Methods 0.000 description 2
- 238000007112 amidation reaction Methods 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 150000003863 ammonium salts Chemical class 0.000 description 2
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 description 2
- 229940092714 benzenesulfonic acid Drugs 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N beta-monoglyceryl stearate Natural products CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- ILAHWRKJUDSMFH-UHFFFAOYSA-N boron tribromide Chemical compound BrB(Br)Br ILAHWRKJUDSMFH-UHFFFAOYSA-N 0.000 description 2
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 2
- 239000000920 calcium hydroxide Substances 0.000 description 2
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 125000001589 carboacyl group Chemical group 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 2
- PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- UXTMROKLAAOEQO-UHFFFAOYSA-N chloroform;ethanol Chemical compound CCO.ClC(Cl)Cl UXTMROKLAAOEQO-UHFFFAOYSA-N 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 229940110456 cocoa butter Drugs 0.000 description 2
- 235000019868 cocoa butter Nutrition 0.000 description 2
- 229940126543 compound 14 Drugs 0.000 description 2
- 229940125758 compound 15 Drugs 0.000 description 2
- 229940125833 compound 23 Drugs 0.000 description 2
- 229940125851 compound 27 Drugs 0.000 description 2
- 229940126214 compound 3 Drugs 0.000 description 2
- 229940125877 compound 31 Drugs 0.000 description 2
- 229940127573 compound 38 Drugs 0.000 description 2
- 229940127271 compound 49 Drugs 0.000 description 2
- RWGFKTVRMDUZSP-UHFFFAOYSA-N cumene Chemical compound CC(C)C1=CC=CC=C1 RWGFKTVRMDUZSP-UHFFFAOYSA-N 0.000 description 2
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 2
- 230000018044 dehydration Effects 0.000 description 2
- 238000006297 dehydration reaction Methods 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 description 2
- YWEUIGNSBFLMFL-UHFFFAOYSA-N diphosphonate Chemical compound O=P(=O)OP(=O)=O YWEUIGNSBFLMFL-UHFFFAOYSA-N 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- AVAACINZEOAHHE-VFZPANTDSA-N doripenem Chemical compound C=1([C@H](C)[C@@H]2[C@H](C(N2C=1C(O)=O)=O)[C@H](O)C)S[C@@H]1CN[C@H](CNS(N)(=O)=O)C1 AVAACINZEOAHHE-VFZPANTDSA-N 0.000 description 2
- 230000032050 esterification Effects 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000011790 ferrous sulphate Substances 0.000 description 2
- 235000003891 ferrous sulphate Nutrition 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 235000001727 glucose Nutrition 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 150000004820 halides Chemical group 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 238000005658 halogenation reaction Methods 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- ZSIAUFGUXNUGDI-UHFFFAOYSA-N hexan-1-ol Chemical compound CCCCCCO ZSIAUFGUXNUGDI-UHFFFAOYSA-N 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 230000003301 hydrolyzing effect Effects 0.000 description 2
- 150000004679 hydroxides Chemical class 0.000 description 2
- 229910052740 iodine Inorganic materials 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 2
- JXDYKVIHCLTXOP-UHFFFAOYSA-N isatin Chemical compound C1=CC=C2C(=O)C(=O)NC2=C1 JXDYKVIHCLTXOP-UHFFFAOYSA-N 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- DBTMGCOVALSLOR-VPNXCSTESA-N laminarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1O[C@@H]1[C@@H](O)C(O[C@H]2[C@@H]([C@@H](CO)OC(O)[C@@H]2O)O)O[C@H](CO)[C@H]1O DBTMGCOVALSLOR-VPNXCSTESA-N 0.000 description 2
- 150000002611 lead compounds Chemical class 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 229910000000 metal hydroxide Inorganic materials 0.000 description 2
- 150000004692 metal hydroxides Chemical class 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 2
- IXLZDUYBUURIQH-UHFFFAOYSA-N methyl 3-(3-ethoxyprop-2-enoylamino)benzoate Chemical compound CCOC=CC(=O)NC1=CC=CC(C(=O)OC)=C1 IXLZDUYBUURIQH-UHFFFAOYSA-N 0.000 description 2
- RPUSRLKKXPQSGP-UHFFFAOYSA-N methyl 3-phenylpropanoate Chemical compound COC(=O)CCC1=CC=CC=C1 RPUSRLKKXPQSGP-UHFFFAOYSA-N 0.000 description 2
- 238000006396 nitration reaction Methods 0.000 description 2
- PIDFDZJZLOTZTM-KHVQSSSXSA-N ombitasvir Chemical compound COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)NC1=CC=C([C@H]2N([C@@H](CC2)C=2C=CC(NC(=O)[C@H]3N(CCC3)C(=O)[C@@H](NC(=O)OC)C(C)C)=CC=2)C=2C=CC(=CC=2)C(C)(C)C)C=C1 PIDFDZJZLOTZTM-KHVQSSSXSA-N 0.000 description 2
- MUMZUERVLWJKNR-UHFFFAOYSA-N oxoplatinum Chemical compound [Pt]=O MUMZUERVLWJKNR-UHFFFAOYSA-N 0.000 description 2
- 229910052763 palladium Inorganic materials 0.000 description 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 125000003884 phenylalkyl group Chemical group 0.000 description 2
- NMHMNPHRMNGLLB-UHFFFAOYSA-N phloretic acid Chemical compound OC(=O)CCC1=CC=C(O)C=C1 NMHMNPHRMNGLLB-UHFFFAOYSA-N 0.000 description 2
- UHZYTMXLRWXGPK-UHFFFAOYSA-N phosphorus pentachloride Chemical compound ClP(Cl)(Cl)(Cl)Cl UHZYTMXLRWXGPK-UHFFFAOYSA-N 0.000 description 2
- DLYUQMMRRRQYAE-UHFFFAOYSA-N phosphorus pentoxide Inorganic materials O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 2
- 229910003446 platinum oxide Inorganic materials 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229920000137 polyphosphoric acid Polymers 0.000 description 2
- 229960003975 potassium Drugs 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 235000007686 potassium Nutrition 0.000 description 2
- 235000011056 potassium acetate Nutrition 0.000 description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- JPJALAQPGMAKDF-UHFFFAOYSA-N selenium dioxide Chemical compound O=[Se]=O JPJALAQPGMAKDF-UHFFFAOYSA-N 0.000 description 2
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 2
- 235000012239 silicon dioxide Nutrition 0.000 description 2
- NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 description 2
- 239000012279 sodium borohydride Substances 0.000 description 2
- 229910000033 sodium borohydride Inorganic materials 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 2
- 239000001119 stannous chloride Substances 0.000 description 2
- 235000011150 stannous chloride Nutrition 0.000 description 2
- KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical compound O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 239000011135 tin Substances 0.000 description 2
- HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 description 2
- LBLYYCQCTBFVLH-UHFFFAOYSA-M toluenesulfonate group Chemical group C=1(C(=CC=CC1)S(=O)(=O)[O-])C LBLYYCQCTBFVLH-UHFFFAOYSA-M 0.000 description 2
- WJKHJLXJJJATHN-UHFFFAOYSA-N triflic anhydride Chemical compound FC(F)(F)S(=O)(=O)OS(=O)(=O)C(F)(F)F WJKHJLXJJJATHN-UHFFFAOYSA-N 0.000 description 2
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- 239000011592 zinc chloride Substances 0.000 description 2
- 235000005074 zinc chloride Nutrition 0.000 description 2
- UAOUIVVJBYDFKD-XKCDOFEDSA-N (1R,9R,10S,11R,12R,15S,18S,21R)-10,11,21-trihydroxy-8,8-dimethyl-14-methylidene-4-(prop-2-enylamino)-20-oxa-5-thia-3-azahexacyclo[9.7.2.112,15.01,9.02,6.012,18]henicosa-2(6),3-dien-13-one Chemical compound C([C@@H]1[C@@H](O)[C@@]23C(C1=C)=O)C[C@H]2[C@]12C(N=C(NCC=C)S4)=C4CC(C)(C)[C@H]1[C@H](O)[C@]3(O)OC2 UAOUIVVJBYDFKD-XKCDOFEDSA-N 0.000 description 1
- ABJSOROVZZKJGI-OCYUSGCXSA-N (1r,2r,4r)-2-(4-bromophenyl)-n-[(4-chlorophenyl)-(2-fluoropyridin-4-yl)methyl]-4-morpholin-4-ylcyclohexane-1-carboxamide Chemical compound C1=NC(F)=CC(C(NC(=O)[C@H]2[C@@H](C[C@@H](CC2)N2CCOCC2)C=2C=CC(Br)=CC=2)C=2C=CC(Cl)=CC=2)=C1 ABJSOROVZZKJGI-OCYUSGCXSA-N 0.000 description 1
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- STBLNCCBQMHSRC-BATDWUPUSA-N (2s)-n-[(3s,4s)-5-acetyl-7-cyano-4-methyl-1-[(2-methylnaphthalen-1-yl)methyl]-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide Chemical compound O=C1[C@@H](NC(=O)[C@H](C)NC)[C@H](C)N(C(C)=O)C2=CC(C#N)=CC=C2N1CC1=C(C)C=CC2=CC=CC=C12 STBLNCCBQMHSRC-BATDWUPUSA-N 0.000 description 1
- UDQTXCHQKHIQMH-KYGLGHNPSA-N (3ar,5s,6s,7r,7ar)-5-(difluoromethyl)-2-(ethylamino)-5,6,7,7a-tetrahydro-3ah-pyrano[3,2-d][1,3]thiazole-6,7-diol Chemical compound S1C(NCC)=N[C@H]2[C@@H]1O[C@H](C(F)F)[C@@H](O)[C@@H]2O UDQTXCHQKHIQMH-KYGLGHNPSA-N 0.000 description 1
- HUWSZNZAROKDRZ-RRLWZMAJSA-N (3r,4r)-3-azaniumyl-5-[[(2s,3r)-1-[(2s)-2,3-dicarboxypyrrolidin-1-yl]-3-methyl-1-oxopentan-2-yl]amino]-5-oxo-4-sulfanylpentane-1-sulfonate Chemical compound OS(=O)(=O)CC[C@@H](N)[C@@H](S)C(=O)N[C@@H]([C@H](C)CC)C(=O)N1CCC(C(O)=O)[C@H]1C(O)=O HUWSZNZAROKDRZ-RRLWZMAJSA-N 0.000 description 1
- JNPGUXGVLNJQSQ-BGGMYYEUSA-M (e,3r,5s)-7-[4-(4-fluorophenyl)-1,2-di(propan-2-yl)pyrrol-3-yl]-3,5-dihydroxyhept-6-enoate Chemical compound CC(C)N1C(C(C)C)=C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)C(C=2C=CC(F)=CC=2)=C1 JNPGUXGVLNJQSQ-BGGMYYEUSA-M 0.000 description 1
- UKDOTCFNLHHKOF-FGRDZWBJSA-N (z)-1-chloroprop-1-ene;(z)-1,2-dichloroethene Chemical group C\C=C/Cl.Cl\C=C/Cl UKDOTCFNLHHKOF-FGRDZWBJSA-N 0.000 description 1
- UOCLXMDMGBRAIB-UHFFFAOYSA-N 1,1,1-trichloroethane Chemical compound CC(Cl)(Cl)Cl UOCLXMDMGBRAIB-UHFFFAOYSA-N 0.000 description 1
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 1
- LLAPDLPYIYKTGQ-UHFFFAOYSA-N 1-aminoethyl Chemical group C[CH]N LLAPDLPYIYKTGQ-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- AWJCCKYFFMSHCJ-UHFFFAOYSA-N 1-methyl-2-oxoquinoline-3-carbaldehyde Chemical compound C1=CC=C2C=C(C=O)C(=O)N(C)C2=C1 AWJCCKYFFMSHCJ-UHFFFAOYSA-N 0.000 description 1
- 125000004343 1-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C([H])([H])[H] 0.000 description 1
- NOGFHTGYPKWWRX-UHFFFAOYSA-N 2,2,6,6-tetramethyloxan-4-one Chemical compound CC1(C)CC(=O)CC(C)(C)O1 NOGFHTGYPKWWRX-UHFFFAOYSA-N 0.000 description 1
- HEWZVZIVELJPQZ-UHFFFAOYSA-N 2,2-dimethoxypropane Chemical compound COC(C)(C)OC HEWZVZIVELJPQZ-UHFFFAOYSA-N 0.000 description 1
- HZNVUJQVZSTENZ-UHFFFAOYSA-N 2,3-dichloro-5,6-dicyano-1,4-benzoquinone Chemical compound ClC1=C(Cl)C(=O)C(C#N)=C(C#N)C1=O HZNVUJQVZSTENZ-UHFFFAOYSA-N 0.000 description 1
- 125000001917 2,4-dinitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C(=C1*)[N+]([O-])=O)[N+]([O-])=O 0.000 description 1
- 125000000301 2-(3-chlorophenyl)ethyl group Chemical group [H]C1=C([H])C(=C([H])C(Cl)=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
- ZAUISSWYLJRJRO-UHFFFAOYSA-N 2-[(4-chlorobenzoyl)amino]-3-(1-ethyl-2-oxoquinolin-4-yl)propanoic acid;hydrate Chemical compound O.C=1C(=O)N(CC)C2=CC=CC=C2C=1CC(C(O)=O)NC(=O)C1=CC=C(Cl)C=C1 ZAUISSWYLJRJRO-UHFFFAOYSA-N 0.000 description 1
- SXOSIZFUMPOHHQ-UHFFFAOYSA-N 2-[(4-chlorobenzoyl)amino]-3-(6-hydroxy-2-oxo-1h-quinolin-3-yl)propanoic acid Chemical compound C=1C2=CC(O)=CC=C2NC(=O)C=1CC(C(=O)O)NC(=O)C1=CC=C(Cl)C=C1 SXOSIZFUMPOHHQ-UHFFFAOYSA-N 0.000 description 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 description 1
- ZYHQGITXIJDDKC-UHFFFAOYSA-N 2-[2-(2-aminophenyl)ethyl]aniline Chemical compound NC1=CC=CC=C1CCC1=CC=CC=C1N ZYHQGITXIJDDKC-UHFFFAOYSA-N 0.000 description 1
- KNDAEDDIIQYRHY-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-3-(piperazin-1-ylmethyl)pyrazol-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C=1C(=NN(C=1)CC(=O)N1CC2=C(CC1)NN=N2)CN1CCNCC1 KNDAEDDIIQYRHY-UHFFFAOYSA-N 0.000 description 1
- DFDFRQYXHWXHTO-UHFFFAOYSA-N 2-amino-3-(1-ethyl-2-oxoquinolin-4-yl)propanoic acid;hydrochloride Chemical compound Cl.C1=CC=C2C(CC(N)C(O)=O)=CC(=O)N(CC)C2=C1 DFDFRQYXHWXHTO-UHFFFAOYSA-N 0.000 description 1
- YVKPCYJMELZZJX-UHFFFAOYSA-N 2-amino-3-(2-oxo-1h-quinolin-3-yl)propanoic acid Chemical compound C1=CC=C2NC(=O)C(CC(N)C(O)=O)=CC2=C1 YVKPCYJMELZZJX-UHFFFAOYSA-N 0.000 description 1
- ZSQZQONBUIXIAB-UHFFFAOYSA-N 2-amino-3-(2-oxo-1h-quinolin-4-yl)propanoic acid;hydrate;hydrochloride Chemical compound O.Cl.C1=CC=C2C(CC(N)C(O)=O)=CC(=O)NC2=C1 ZSQZQONBUIXIAB-UHFFFAOYSA-N 0.000 description 1
- BYEIWWHJEJCNKE-UHFFFAOYSA-N 2-amino-3-(6-methoxy-2-oxo-1h-quinolin-3-yl)propanoic acid;hydrochloride Chemical compound Cl.N1C(=O)C(CC(N)C(O)=O)=CC2=CC(OC)=CC=C21 BYEIWWHJEJCNKE-UHFFFAOYSA-N 0.000 description 1
- YSUIQYOGTINQIN-UZFYAQMZSA-N 2-amino-9-[(1S,6R,8R,9S,10R,15R,17R,18R)-8-(6-aminopurin-9-yl)-9,18-difluoro-3,12-dihydroxy-3,12-bis(sulfanylidene)-2,4,7,11,13,16-hexaoxa-3lambda5,12lambda5-diphosphatricyclo[13.2.1.06,10]octadecan-17-yl]-1H-purin-6-one Chemical compound NC1=NC2=C(N=CN2[C@@H]2O[C@@H]3COP(S)(=O)O[C@@H]4[C@@H](COP(S)(=O)O[C@@H]2[C@@H]3F)O[C@H]([C@H]4F)N2C=NC3=C2N=CN=C3N)C(=O)N1 YSUIQYOGTINQIN-UZFYAQMZSA-N 0.000 description 1
- 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 description 1
- ZFFBIQMNKOJDJE-UHFFFAOYSA-N 2-bromo-1,2-diphenylethanone Chemical compound C=1C=CC=CC=1C(Br)C(=O)C1=CC=CC=C1 ZFFBIQMNKOJDJE-UHFFFAOYSA-N 0.000 description 1
- 125000006280 2-bromobenzyl group Chemical group [H]C1=C([H])C(Br)=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 125000006276 2-bromophenyl group Chemical group [H]C1=C([H])C(Br)=C(*)C([H])=C1[H] 0.000 description 1
- 125000004974 2-butenyl group Chemical group C(C=CC)* 0.000 description 1
- 125000000069 2-butynyl group Chemical group [H]C([H])([H])C#CC([H])([H])* 0.000 description 1
- 125000006282 2-chlorobenzyl group Chemical group [H]C1=C([H])C(Cl)=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 description 1
- SDKQWXCBSNMYBN-UHFFFAOYSA-N 2-chloroquinoline-3-carbaldehyde Chemical compound C1=CC=C2C=C(C=O)C(Cl)=NC2=C1 SDKQWXCBSNMYBN-UHFFFAOYSA-N 0.000 description 1
- 125000004847 2-fluorobenzyl group Chemical group [H]C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 description 1
- 125000006040 2-hexenyl group Chemical group 0.000 description 1
- 125000006481 2-iodobenzyl group Chemical group [H]C1=C([H])C(I)=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 125000006304 2-iodophenyl group Chemical group [H]C1=C([H])C(I)=C(*)C([H])=C1[H] 0.000 description 1
- FLFWJIBUZQARMD-UHFFFAOYSA-N 2-mercapto-1,3-benzoxazole Chemical compound C1=CC=C2OC(S)=NC2=C1 FLFWJIBUZQARMD-UHFFFAOYSA-N 0.000 description 1
- 125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 description 1
- CMWKITSNTDAEDT-UHFFFAOYSA-N 2-nitrobenzaldehyde Chemical compound [O-][N+](=O)C1=CC=CC=C1C=O CMWKITSNTDAEDT-UHFFFAOYSA-N 0.000 description 1
- XOQQVKDBGLYPGH-UHFFFAOYSA-N 2-oxo-1h-quinoline-3-carboxylic acid Chemical compound C1=CC=C2NC(=O)C(C(=O)O)=CC2=C1 XOQQVKDBGLYPGH-UHFFFAOYSA-N 0.000 description 1
- 125000006024 2-pentenyl group Chemical group 0.000 description 1
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 description 1
- 125000004362 3,4,5-trichlorophenyl group Chemical group [H]C1=C(Cl)C(Cl)=C(Cl)C([H])=C1* 0.000 description 1
- 125000005809 3,4,5-trimethoxyphenyl group Chemical group [H]C1=C(OC([H])([H])[H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 description 1
- 125000006512 3,4-dichlorobenzyl group Chemical group [H]C1=C(Cl)C(Cl)=C([H])C(=C1[H])C([H])([H])* 0.000 description 1
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 description 1
- 125000006509 3,4-difluorobenzyl group Chemical group [H]C1=C(F)C(F)=C([H])C(=C1[H])C([H])([H])* 0.000 description 1
- 125000003762 3,4-dimethoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 description 1
- LJGHYPLBDBRCRZ-UHFFFAOYSA-N 3-(3-aminophenyl)sulfonylaniline Chemical compound NC1=CC=CC(S(=O)(=O)C=2C=C(N)C=CC=2)=C1 LJGHYPLBDBRCRZ-UHFFFAOYSA-N 0.000 description 1
- QBWKPGNFQQJGFY-QLFBSQMISA-N 3-[(1r)-1-[(2r,6s)-2,6-dimethylmorpholin-4-yl]ethyl]-n-[6-methyl-3-(1h-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-1,2-thiazol-5-amine Chemical compound N1([C@H](C)C2=NSC(NC=3C4=NC=C(N4C=C(C)N=3)C3=CNN=C3)=C2)C[C@H](C)O[C@H](C)C1 QBWKPGNFQQJGFY-QLFBSQMISA-N 0.000 description 1
- BGAJNPLDJJBRHK-UHFFFAOYSA-N 3-[2-[5-(3-chloro-4-propan-2-yloxyphenyl)-1,3,4-thiadiazol-2-yl]-3-methyl-6,7-dihydro-4h-pyrazolo[4,3-c]pyridin-5-yl]propanoic acid Chemical compound C1=C(Cl)C(OC(C)C)=CC=C1C1=NN=C(N2C(=C3CN(CCC(O)=O)CCC3=N2)C)S1 BGAJNPLDJJBRHK-UHFFFAOYSA-N 0.000 description 1
- XFDUHJPVQKIXHO-UHFFFAOYSA-N 3-aminobenzoic acid Chemical compound NC1=CC=CC(C(O)=O)=C1 XFDUHJPVQKIXHO-UHFFFAOYSA-N 0.000 description 1
- 125000006279 3-bromobenzyl group Chemical group [H]C1=C([H])C(=C([H])C(Br)=C1[H])C([H])([H])* 0.000 description 1
- 125000006275 3-bromophenyl group Chemical group [H]C1=C([H])C(Br)=C([H])C(*)=C1[H] 0.000 description 1
- 125000004975 3-butenyl group Chemical group C(CC=C)* 0.000 description 1
- 125000000474 3-butynyl group Chemical group [H]C#CC([H])([H])C([H])([H])* 0.000 description 1
- FRXJYUFHAXXSAL-UHFFFAOYSA-N 3-chloro-n-phenylpropanamide Chemical compound ClCCC(=O)NC1=CC=CC=C1 FRXJYUFHAXXSAL-UHFFFAOYSA-N 0.000 description 1
- 125000003852 3-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C(Cl)=C1[H])C([H])([H])* 0.000 description 1
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 description 1
- 125000006284 3-fluorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C(F)=C1[H])C([H])([H])* 0.000 description 1
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 description 1
- 125000004208 3-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C([H])C(*)=C1[H] 0.000 description 1
- 125000006482 3-iodobenzyl group Chemical group [H]C1=C([H])C(=C([H])C(I)=C1[H])C([H])([H])* 0.000 description 1
- 125000006305 3-iodophenyl group Chemical group [H]C1=C([H])C(I)=C([H])C(*)=C1[H] 0.000 description 1
- JSGVZVOGOQILFM-UHFFFAOYSA-N 3-methoxy-1-butanol Chemical compound COC(C)CCO JSGVZVOGOQILFM-UHFFFAOYSA-N 0.000 description 1
- 125000006201 3-phenylpropyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- IPQDJUJVYXUXJQ-UHFFFAOYSA-N 4-(3-methoxy-3-oxopropyl)-3-nitrobenzoic acid Chemical compound COC(=O)CCC1=CC=C(C(O)=O)C=C1[N+]([O-])=O IPQDJUJVYXUXJQ-UHFFFAOYSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- 125000004042 4-aminobutyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] 0.000 description 1
- 125000006281 4-bromobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1Br)C([H])([H])* 0.000 description 1
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 description 1
- 125000006283 4-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])* 0.000 description 1
- 125000004860 4-ethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004176 4-fluorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])* 0.000 description 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 description 1
- 125000004203 4-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 125000006483 4-iodobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1I)C([H])([H])* 0.000 description 1
- 125000006306 4-iodophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1I 0.000 description 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 241000586542 Aonidiella citrina Species 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 239000004342 Benzoyl peroxide Substances 0.000 description 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
- QUMCIHKVKQYNPA-RUZDIDTESA-N C1(CCCCC1)CN1[C@@H](C=2N(C=3C=NC(=NC1=3)NC1=C(C=C(C(=O)NC3CCN(CC3)C)C=C1)OC)C(=NN=2)C)CC Chemical compound C1(CCCCC1)CN1[C@@H](C=2N(C=3C=NC(=NC1=3)NC1=C(C=C(C(=O)NC3CCN(CC3)C)C=C1)OC)C(=NN=2)C)CC QUMCIHKVKQYNPA-RUZDIDTESA-N 0.000 description 1
- JGLMVXWAHNTPRF-CMDGGOBGSA-N CCN1N=C(C)C=C1C(=O)NC1=NC2=CC(=CC(OC)=C2N1C\C=C\CN1C(NC(=O)C2=CC(C)=NN2CC)=NC2=CC(=CC(OCCCN3CCOCC3)=C12)C(N)=O)C(N)=O Chemical compound CCN1N=C(C)C=C1C(=O)NC1=NC2=CC(=CC(OC)=C2N1C\C=C\CN1C(NC(=O)C2=CC(C)=NN2CC)=NC2=CC(=CC(OCCCN3CCOCC3)=C12)C(N)=O)C(N)=O JGLMVXWAHNTPRF-CMDGGOBGSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- YXHKONLOYHBTNS-UHFFFAOYSA-N Diazomethane Chemical compound C=[N+]=[N-] YXHKONLOYHBTNS-UHFFFAOYSA-N 0.000 description 1
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 206010061459 Gastrointestinal ulcer Diseases 0.000 description 1
- DCXXMTOCNZCJGO-UHFFFAOYSA-N Glycerol trioctadecanoate Natural products CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- RJUFJBKOKNCXHH-UHFFFAOYSA-N Methyl propionate Chemical compound CCC(=O)OC RJUFJBKOKNCXHH-UHFFFAOYSA-N 0.000 description 1
- SUAKHGWARZSWIH-UHFFFAOYSA-N N,Nâdiethylformamide Chemical compound CCN(CC)C=O SUAKHGWARZSWIH-UHFFFAOYSA-N 0.000 description 1
- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 description 1
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 description 1
- 238000007126 N-alkylation reaction Methods 0.000 description 1
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 description 1
- 229920001800 Shellac Polymers 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 1
- 244000299461 Theobroma cacao Species 0.000 description 1
- 235000005764 Theobroma cacao ssp. cacao Nutrition 0.000 description 1
- 235000005767 Theobroma cacao ssp. sphaerocarpum Nutrition 0.000 description 1
- 241001061127 Thione Species 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- LJOOWESTVASNOG-UFJKPHDISA-N [(1s,3r,4ar,7s,8s,8as)-3-hydroxy-8-[2-[(4r)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl] (2s)-2-methylbutanoate Chemical compound C([C@H]1[C@@H](C)C=C[C@H]2C[C@@H](O)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)CC1C[C@@H](O)CC(=O)O1 LJOOWESTVASNOG-UFJKPHDISA-N 0.000 description 1
- PSLUFJFHTBIXMW-WYEYVKMPSA-N [(3r,4ar,5s,6s,6as,10s,10ar,10bs)-3-ethenyl-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-6-(2-pyridin-2-ylethylcarbamoyloxy)-5,6,6a,8,9,10-hexahydro-2h-benzo[f]chromen-5-yl] acetate Chemical compound O([C@@H]1[C@@H]([C@]2(O[C@](C)(CC(=O)[C@]2(O)[C@@]2(C)[C@@H](O)CCC(C)(C)[C@@H]21)C=C)C)OC(=O)C)C(=O)NCCC1=CC=CC=N1 PSLUFJFHTBIXMW-WYEYVKMPSA-N 0.000 description 1
- SMNRFWMNPDABKZ-WVALLCKVSA-N [[(2R,3S,4R,5S)-5-(2,6-dioxo-3H-pyridin-3-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [[[(2R,3S,4S,5R,6R)-4-fluoro-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] hydrogen phosphate Chemical compound OC[C@H]1O[C@H](OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)C2C=CC(=O)NC2=O)[C@H](O)[C@@H](F)[C@@H]1O SMNRFWMNPDABKZ-WVALLCKVSA-N 0.000 description 1
- CWVZGJORVTZXFW-UHFFFAOYSA-N [benzyl(dimethyl)silyl]methyl carbamate Chemical compound NC(=O)OC[Si](C)(C)CC1=CC=CC=C1 CWVZGJORVTZXFW-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- YLEIFZAVNWDOBM-ZTNXSLBXSA-N ac1l9hc7 Chemical compound C([C@H]12)C[C@@H](C([C@@H](O)CC3)(C)C)[C@@]43C[C@@]14CC[C@@]1(C)[C@@]2(C)C[C@@H]2O[C@]3(O)[C@H](O)C(C)(C)O[C@@H]3[C@@H](C)[C@H]12 YLEIFZAVNWDOBM-ZTNXSLBXSA-N 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 229960001413 acetanilide Drugs 0.000 description 1
- DYRDKSSFIWVSNM-UHFFFAOYSA-N acetoacetanilide Chemical compound CC(=O)CC(=O)NC1=CC=CC=C1 DYRDKSSFIWVSNM-UHFFFAOYSA-N 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 125000004423 acyloxy group Chemical group 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 description 1
- 150000001339 alkali metal compounds Chemical class 0.000 description 1
- 229910001963 alkali metal nitrate Inorganic materials 0.000 description 1
- 230000002152 alkylating effect Effects 0.000 description 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 description 1
- 230000002862 amidating effect Effects 0.000 description 1
- 238000010976 amide bond formation reaction Methods 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 125000004103 aminoalkyl group Chemical group 0.000 description 1
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- UYJXRRSPUVSSMN-UHFFFAOYSA-P ammonium sulfide Chemical compound [NH4+].[NH4+].[S-2] UYJXRRSPUVSSMN-UHFFFAOYSA-P 0.000 description 1
- 229940095564 anhydrous calcium sulfate Drugs 0.000 description 1
- 229940040526 anhydrous sodium acetate Drugs 0.000 description 1
- 230000000767 anti-ulcer Effects 0.000 description 1
- 239000000010 aprotic solvent Substances 0.000 description 1
- 150000001491 aromatic compounds Chemical class 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 150000004054 benzoquinones Chemical class 0.000 description 1
- AQIHMSVIAGNIDM-UHFFFAOYSA-N benzoyl bromide Chemical compound BrC(=O)C1=CC=CC=C1 AQIHMSVIAGNIDM-UHFFFAOYSA-N 0.000 description 1
- PASDCCFISLVPSO-UHFFFAOYSA-N benzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1 PASDCCFISLVPSO-UHFFFAOYSA-N 0.000 description 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
- 235000019400 benzoyl peroxide Nutrition 0.000 description 1
- 238000006480 benzoylation reaction Methods 0.000 description 1
- 125000001231 benzoyloxy group Chemical group C(C1=CC=CC=C1)(=O)O* 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- SIPUZPBQZHNSDW-UHFFFAOYSA-N bis(2-methylpropyl)aluminum Chemical compound CC(C)C[Al]CC(C)C SIPUZPBQZHNSDW-UHFFFAOYSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- ODWXUNBKCRECNW-UHFFFAOYSA-M bromocopper(1+) Chemical compound Br[Cu+] ODWXUNBKCRECNW-UHFFFAOYSA-M 0.000 description 1
- 230000005587 bubbling Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 235000014121 butter Nutrition 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004744 butyloxycarbonyl group Chemical group 0.000 description 1
- 235000001046 cacaotero Nutrition 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000013877 carbamide Nutrition 0.000 description 1
- 150000001718 carbodiimides Chemical class 0.000 description 1
- 150000001721 carbon Chemical group 0.000 description 1
- QGJOPFRUJISHPQ-NJFSPNSNSA-N carbon disulfide-14c Chemical compound S=[14C]=S QGJOPFRUJISHPQ-NJFSPNSNSA-N 0.000 description 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 150000001244 carboxylic acid anhydrides Chemical class 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- KXZJHVJKXJLBKO-UHFFFAOYSA-N chembl1408157 Chemical compound N=1C2=CC=CC=C2C(C(=O)O)=CC=1C1=CC=C(O)C=C1 KXZJHVJKXJLBKO-UHFFFAOYSA-N 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- HRYZWHHZPQKTII-UHFFFAOYSA-N chloroethane Chemical compound CCCl HRYZWHHZPQKTII-UHFFFAOYSA-N 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 229940125810 compound 20 Drugs 0.000 description 1
- 229940125846 compound 25 Drugs 0.000 description 1
- 229940127204 compound 29 Drugs 0.000 description 1
- 229940125878 compound 36 Drugs 0.000 description 1
- 229940125936 compound 42 Drugs 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- JGDFBJMWFLXCLJ-UHFFFAOYSA-N copper chromite Chemical compound [Cu]=O.[Cu]=O.O=[Cr]O[Cr]=O JGDFBJMWFLXCLJ-UHFFFAOYSA-N 0.000 description 1
- 229910000365 copper sulfate Inorganic materials 0.000 description 1
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 description 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
- DOBRDRYODQBAMW-UHFFFAOYSA-N copper(i) cyanide Chemical compound [Cu+].N#[C-] DOBRDRYODQBAMW-UHFFFAOYSA-N 0.000 description 1
- DMSZORWOGDLWGN-UHFFFAOYSA-N ctk1a3526 Chemical compound NP(N)(N)=O DMSZORWOGDLWGN-UHFFFAOYSA-N 0.000 description 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- UKJLNMAFNRKWGR-UHFFFAOYSA-N cyclohexatrienamine Chemical group NC1=CC=C=C[CH]1 UKJLNMAFNRKWGR-UHFFFAOYSA-N 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000000640 cyclooctyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
- 238000006704 dehydrohalogenation reaction Methods 0.000 description 1
- 239000002274 desiccant Substances 0.000 description 1
- ISOLMABRZPQKOV-UHFFFAOYSA-N diethyl 2-acetamidopropanedioate Chemical compound CCOC(=O)C(NC(C)=O)C(=O)OCC ISOLMABRZPQKOV-UHFFFAOYSA-N 0.000 description 1
- DENRZWYUOJLTMF-UHFFFAOYSA-N diethyl sulfate Chemical compound CCOS(=O)(=O)OCC DENRZWYUOJLTMF-UHFFFAOYSA-N 0.000 description 1
- 229940008406 diethyl sulfate Drugs 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- VAYGXNSJCAHWJZ-UHFFFAOYSA-N dimethyl sulfate Chemical compound COS(=O)(=O)OC VAYGXNSJCAHWJZ-UHFFFAOYSA-N 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 208000000718 duodenal ulcer Diseases 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 239000002662 enteric coated tablet Substances 0.000 description 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 description 1
- RWBYCMPOFNRISR-UHFFFAOYSA-N ethyl 4-chlorobenzoate Chemical compound CCOC(=O)C1=CC=C(Cl)C=C1 RWBYCMPOFNRISR-UHFFFAOYSA-N 0.000 description 1
- YHCVRAUCGVYFQA-UHFFFAOYSA-N ethyl bromate Chemical compound CCOBr(=O)=O YHCVRAUCGVYFQA-UHFFFAOYSA-N 0.000 description 1
- 229960003750 ethyl chloride Drugs 0.000 description 1
- RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 description 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 1
- 239000007941 film coated tablet Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- ZTQSADJAYQOCDD-UHFFFAOYSA-N ginsenoside-Rd2 Natural products C1CC(C2(CCC3C(C)(C)C(OC4C(C(O)C(O)C(CO)O4)O)CCC3(C)C2CC2O)C)(C)C2C1C(C)(CCC=C(C)C)OC(C(C(O)C1O)O)OC1COC1OCC(O)C(O)C1O ZTQSADJAYQOCDD-UHFFFAOYSA-N 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- JAXFJECJQZDFJS-XHEPKHHKSA-N gtpl8555 Chemical compound OC(=O)C[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@H](B1O[C@@]2(C)[C@H]3C[C@H](C3(C)C)C[C@H]2O1)CCC1=CC=C(F)C=C1 JAXFJECJQZDFJS-XHEPKHHKSA-N 0.000 description 1
- XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 1
- 125000004836 hexamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000003707 hexyloxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O* 0.000 description 1
- 125000005935 hexyloxycarbonyl group Chemical group 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 229910000040 hydrogen fluoride Inorganic materials 0.000 description 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 239000002198 insoluble material Substances 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- FBAFATDZDUQKNH-UHFFFAOYSA-M iron chloride Chemical compound [Cl-].[Fe] FBAFATDZDUQKNH-UHFFFAOYSA-M 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000005928 isopropyloxycarbonyl group Chemical group [H]C([H])([H])C([H])(OC(*)=O)C([H])([H])[H] 0.000 description 1
- 239000000644 isotonic solution Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 229910052976 metal sulfide Inorganic materials 0.000 description 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
- JIQNWFBLYKVZFY-UHFFFAOYSA-N methoxycyclohexatriene Chemical compound COC1=C[C]=CC=C1 JIQNWFBLYKVZFY-UHFFFAOYSA-N 0.000 description 1
- WZTUDEBHYBHGHD-UHFFFAOYSA-N methyl 3-[4-(2-chloroacetyl)phenyl]propanoate Chemical compound COC(=O)CCC1=CC=C(C(=O)CCl)C=C1 WZTUDEBHYBHGHD-UHFFFAOYSA-N 0.000 description 1
- VZDNXXPBYLGWOS-UHFFFAOYSA-N methyl 3-aminobenzoate Chemical compound COC(=O)C1=CC=CC(N)=C1 VZDNXXPBYLGWOS-UHFFFAOYSA-N 0.000 description 1
- QQHNGZNHRRLNKI-UHFFFAOYSA-N methyl carbonobromidate Chemical compound COC(Br)=O QQHNGZNHRRLNKI-UHFFFAOYSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- XMJHPCRAQCTCFT-UHFFFAOYSA-N methyl chloroformate Chemical compound COC(Cl)=O XMJHPCRAQCTCFT-UHFFFAOYSA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 229940017219 methyl propionate Drugs 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
- BDRTVPCFKSUHCJ-UHFFFAOYSA-N molecular hydrogen;potassium Chemical compound [K].[H][H] BDRTVPCFKSUHCJ-UHFFFAOYSA-N 0.000 description 1
- XONPDZSGENTBNJ-UHFFFAOYSA-N molecular hydrogen;sodium Chemical compound [Na].[H][H] XONPDZSGENTBNJ-UHFFFAOYSA-N 0.000 description 1
- QAXZWHGWYSJAEI-UHFFFAOYSA-N n,n-dimethylformamide;ethanol Chemical compound CCO.CN(C)C=O QAXZWHGWYSJAEI-UHFFFAOYSA-N 0.000 description 1
- FJLHLDBEZKTSOK-UHFFFAOYSA-N n-ethyl-n-methylformamide Chemical compound CCN(C)C=O FJLHLDBEZKTSOK-UHFFFAOYSA-N 0.000 description 1
- JIKUXBYRTXDNIY-UHFFFAOYSA-N n-methyl-n-phenylformamide Chemical compound O=CN(C)C1=CC=CC=C1 JIKUXBYRTXDNIY-UHFFFAOYSA-N 0.000 description 1
- IOMMMLWIABWRKL-WUTDNEBXSA-N nazartinib Chemical compound C1N(C(=O)/C=C/CN(C)C)CCCC[C@H]1N1C2=C(Cl)C=CC=C2N=C1NC(=O)C1=CC=NC(C)=C1 IOMMMLWIABWRKL-WUTDNEBXSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- PFGVNLZDWRZPJW-OPAMFIHVSA-N otamixaban Chemical compound C([C@@H](C(=O)OC)[C@@H](C)NC(=O)C=1C=CC(=CC=1)C=1C=C[N+]([O-])=CC=1)C1=CC=CC(C(N)=N)=C1 PFGVNLZDWRZPJW-OPAMFIHVSA-N 0.000 description 1
- 229940045681 other alkylating agent in atc Drugs 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 125000005740 oxycarbonyl group Chemical group [*:1]OC([*:2])=O 0.000 description 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 1
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 description 1
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 description 1
- 229910003445 palladium oxide Inorganic materials 0.000 description 1
- JQPTYAILLJKUCY-UHFFFAOYSA-N palladium(ii) oxide Chemical compound [O-2].[Pd+2] JQPTYAILLJKUCY-UHFFFAOYSA-N 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- UXCDUFKZSUBXGM-UHFFFAOYSA-N phosphoric tribromide Chemical compound BrP(Br)(Br)=O UXCDUFKZSUBXGM-UHFFFAOYSA-N 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000012746 preparative thin layer chromatography Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- OVARTBFNCCXQKS-UHFFFAOYSA-N propan-2-one;hydrate Chemical compound O.CC(C)=O OVARTBFNCCXQKS-UHFFFAOYSA-N 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical group CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 description 1
- 125000004742 propyloxycarbonyl group Chemical group 0.000 description 1
- 239000003586 protic polar solvent Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000007348 radical reaction Methods 0.000 description 1
- 238000006798 ring closing metathesis reaction Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- LFAGQMCIGQNPJG-UHFFFAOYSA-N silver cyanide Chemical compound [Ag+].N#[C-] LFAGQMCIGQNPJG-UHFFFAOYSA-N 0.000 description 1
- 229940098221 silver cyanide Drugs 0.000 description 1
- 229910001923 silver oxide Inorganic materials 0.000 description 1
- 235000020374 simple syrup Nutrition 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 239000004317 sodium nitrate Substances 0.000 description 1
- 235000010344 sodium nitrate Nutrition 0.000 description 1
- KKCBUQHMOMHUOY-UHFFFAOYSA-N sodium oxide Chemical compound [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 description 1
- 229910001948 sodium oxide Inorganic materials 0.000 description 1
- JXKPEJDQGNYQSM-UHFFFAOYSA-M sodium propionate Chemical compound [Na+].CCC([O-])=O JXKPEJDQGNYQSM-UHFFFAOYSA-M 0.000 description 1
- 239000004324 sodium propionate Substances 0.000 description 1
- 235000010334 sodium propionate Nutrition 0.000 description 1
- 229960003212 sodium propionate Drugs 0.000 description 1
- GRONZTPUWOOUFQ-UHFFFAOYSA-M sodium;methanol;hydroxide Chemical compound [OH-].[Na+].OC GRONZTPUWOOUFQ-UHFFFAOYSA-M 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000001256 steam distillation Methods 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 description 1
- 229960002317 succinimide Drugs 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 150000004763 sulfides Chemical class 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 238000003419 tautomerization reaction Methods 0.000 description 1
- FRACPXUHUTXLCX-BELIEFIBSA-N tert-butyl N-{1-[(1S)-1-{[(1R,2S)-1-(benzylcarbamoyl)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]carbamoyl}-2-cyclopropylethyl]-2-oxopyridin-3-yl}carbamate Chemical compound CC(C)(C)OC(=O)NC1=CC=CN(C1=O)[C@@H](CC2CC2)C(=O)N[C@@H](C[C@@H]3CCNC3=O)[C@H](C(=O)NCC4=CC=CC=C4)O FRACPXUHUTXLCX-BELIEFIBSA-N 0.000 description 1
- RKSOPLXZQNSWAS-UHFFFAOYSA-N tert-butyl bromide Chemical compound CC(C)(C)Br RKSOPLXZQNSWAS-UHFFFAOYSA-N 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- UGNWTBMOAKPKBL-UHFFFAOYSA-N tetrachloro-1,4-benzoquinone Chemical compound ClC1=C(Cl)C(=O)C(Cl)=C(Cl)C1=O UGNWTBMOAKPKBL-UHFFFAOYSA-N 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 229910052718 tin Inorganic materials 0.000 description 1
- 229910001887 tin oxide Inorganic materials 0.000 description 1
- XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- DGCFCIXSJPYNLX-UHFFFAOYSA-N trichloromethylsulfonyl trichloromethanesulfonate Chemical compound ClC(Cl)(Cl)S(=O)(=O)OS(=O)(=O)C(Cl)(Cl)Cl DGCFCIXSJPYNLX-UHFFFAOYSA-N 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- BFDBKMOZYNOTPK-UHFFFAOYSA-N vonoprazan Chemical compound C=1C=CN=CC=1S(=O)(=O)N1C=C(CNC)C=C1C1=CC=CC=C1F BFDBKMOZYNOTPK-UHFFFAOYSA-N 0.000 description 1
- 239000003021 water soluble solvent Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Landscapes
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
æ¬çºæã¯ãæ°èŠãªã«ã«ãã¹ããªã«èªå°äœããã
ã«è©³ããã¯ãäžè¬åŒ K0009 åŒäžãR1ã¯æ°ŽçŽ ååãäœçŽã¢ã«ãã«åºãäœ
çŽã¢ã«ã±ãã«åºãäœçŽã¢ã«ããã«åºãŸãã¯ããšã
ã«äœçŽã¢ã«ãã«åºïŒR2ã¯æ°ŽçŽ ååãæ°Žé žåºãäœ
çŽã¢ã«ãã«åºãŸãã¯äœçŽã¢ã«ã³ãã·åºïŒR3ã¯æ°Ž
é žåºãã·ã¯ãã¢ã«ãã«ç°äžã«çœ®æåºãæããã·ã¯
ãã¢ã«ãã«äœçŽã¢ã«ãã«ã¢ããåºïŒè©²ã·ã¯ãã¢ã«
ãã«ç°äžã®çœ®æåºã¯ã«ã«ããã·åºãŸãã¯äœçŽã¢ã«
ã³ãã·ã«ã«ããã«åºã§ããïŒïŒR4ã¯æ°ŽçŽ ååãŸã
ã¯åºâCOR6ïŒR6ã¯çœ®æåºãšããŠã¢ããäœçŽã¢ã«
ãã«åºãæããããšã®ããã·ã¯ãã¢ã«ãã«åºãã
ãšãã«ç°äžã«çœ®æåºãšããŠããã²ã³ååãäœçŽã¢
ã«ãã«åºãäœçŽã¢ã«ã³ãã·åºããããåºãæ°Žé žåº
ããã³ã¢ããåºããéžã°ããåºã®ïŒãïŒåãæã
ãããšã®ããããšãã«åºãããšãã«ç°äžã«çœ®æåº
ãšããŠããã²ã³ååãæããããšã®ããããšãã«
äœçŽã¢ã«ãã«åºããŸãã¯äœçŽã¢ã«ãã«ãã¢ãŸãªã«
åºãããªãžã«åºãŸãã¯ããªã«åºããéžã°ããäžé£œ
åè€çŽ ç°åºïŒïŒR5ã¯æ°ŽçŽ ååãŸãã¯çœ®æåºãšããŠ
ããã²ã³ååãæããããšãã«ã¹ã«ããã«åºïŒïŒ¡
ã¯äœçŽã¢ã«ãã¬ã³åºïŒïœã¯ïŒã瀺ãã眮æåºã®åŒ
ã«è©³ããã¯ãäžè¬åŒ K0009 åŒäžãR1ã¯æ°ŽçŽ ååãäœçŽã¢ã«ãã«åºãäœ
çŽã¢ã«ã±ãã«åºãäœçŽã¢ã«ããã«åºãŸãã¯ããšã
ã«äœçŽã¢ã«ãã«åºïŒR2ã¯æ°ŽçŽ ååãæ°Žé žåºãäœ
çŽã¢ã«ãã«åºãŸãã¯äœçŽã¢ã«ã³ãã·åºïŒR3ã¯æ°Ž
é žåºãã·ã¯ãã¢ã«ãã«ç°äžã«çœ®æåºãæããã·ã¯
ãã¢ã«ãã«äœçŽã¢ã«ãã«ã¢ããåºïŒè©²ã·ã¯ãã¢ã«
ãã«ç°äžã®çœ®æåºã¯ã«ã«ããã·åºãŸãã¯äœçŽã¢ã«
ã³ãã·ã«ã«ããã«åºã§ããïŒïŒR4ã¯æ°ŽçŽ ååãŸã
ã¯åºâCOR6ïŒR6ã¯çœ®æåºãšããŠã¢ããäœçŽã¢ã«
ãã«åºãæããããšã®ããã·ã¯ãã¢ã«ãã«åºãã
ãšãã«ç°äžã«çœ®æåºãšããŠããã²ã³ååãäœçŽã¢
ã«ãã«åºãäœçŽã¢ã«ã³ãã·åºããããåºãæ°Žé žåº
ããã³ã¢ããåºããéžã°ããåºã®ïŒãïŒåãæã
ãããšã®ããããšãã«åºãããšãã«ç°äžã«çœ®æåº
ãšããŠããã²ã³ååãæããããšã®ããããšãã«
äœçŽã¢ã«ãã«åºããŸãã¯äœçŽã¢ã«ãã«ãã¢ãŸãªã«
åºãããªãžã«åºãŸãã¯ããªã«åºããéžã°ããäžé£œ
åè€çŽ ç°åºïŒïŒR5ã¯æ°ŽçŽ ååãŸãã¯çœ®æåºãšããŠ
ããã²ã³ååãæããããšãã«ã¹ã«ããã«åºïŒïŒ¡
ã¯äœçŽã¢ã«ãã¬ã³åºïŒïœã¯ïŒã瀺ãã眮æåºã®åŒ
ãåŒãã«ãããâCHã
ã¯âCHïŒïŒ£ãŸãã¯âCH2âCHãæå³ãã
ãã€ãã®çœ®æåºã®çœ®æäœçœ®ã¯ã«ã«ãã¹ããªã«éªšæ Œ
ã®ïŒïŒïŒïŒïŒãŸãã¯ïŒäœã®ããããã§ããããŸã
ã«ã«ãã¹ããªã«éªšæ Œã®ïŒäœãšïŒäœéã®çµåã¯äžé
çµåãŸãã¯äºéçµåã瀺ãã ã§ç€ºãããã«ã«ãã¹ããªã«èªå°äœãŸãã¯ãã®å¡©ã
掻æ§æåãšããŠå«æããããšãç¹åŸŽãšããæ朰ç
å€ã«é¢ããã æ¬çºæã®ååç©ã¯æ朰çäœçšãæããäŸãã°è
朰çãåäºæè žæœ°çãªã©ã®æ¶ååšç³»ã®æœ°çã®æ²»ç
å€ãšããŠæçšã§ãããæ¬çºæã®ååç©ã¯ããšã
ã«ãå®éšé ¢é žæœ°çãçŒçŒæœ°çãªã©ã®æ ¢æ§æœ°çç æ
ã«å¯ŸããŠé¡èãªäºé²ããã³æ²»çå¹æãæããç¹ã«
ç¹åŸŽãããããããæ¯æ§ããã³å¯äœçšã匱ããæ ¢
æ§æœ°çã«å¯ŸããŠæå¹ãªè¬å€ã§ãããæ¬çºæã®åå
ç©ã¯ãŸããå å æ§ããã¹ã¿ã°ã©ã³ãžã³E2éãå¢
å ãããäœçšãæããããã¹ã¿ã°ã©ã³ãžã³E2ã«
ç±æ¥ããè¬å¹ãäŸãã°ã朰çã®äºé²ããã³æ²»çè¬
ãªã©ãšããŠæçšã§ããã æ¬æ现æžã«ãããŠãäœçŽã¢ã«ãã«ãšããŠã¯ççŽ
æ°ïŒãïŒåã®çŽéãŸãã¯åæéã¢ã«ãã«ãäŸãã°
ã¡ãã«ããšãã«ããããã«ãã€ãœãããã«ããã
ã«ãã€ãœããã«ããã³ãã«ãããã·ã«ãªã©ãæã
ãããäœçŽã¢ã«ã±ãã«ãšããŠã¯ççŽ æ°ïŒãïŒåã®
çŽéãŸãã¯åæéã¢ã«ã±ãã«ãäŸãã°ããã«ãã¢
ãªã«ãïŒâãããã«ãïŒâãããã«ãïŒâã¡ãã«
ã¢ãªã«ãïŒâãã³ããã«ãïŒâããã»ãã«ãªã©ã
ããã«äœçŽã¢ã«ããã«ãšããŠã¯ççŽ æ°ïŒãïŒåã®
çŽéãŸãã¯åæéã¢ã«ããã«ãäŸãã°ãšããã«ã
ïŒâããããã«ãïŒâãããã«ãïŒâãããã«ã
ïŒâã¡ãã«âïŒâããããã«ãïŒâãã³ããã«ã
ïŒâããã·ãã«ãªã©ãæããããã äœçŽã¢ã«ãã¬ã³åºãšããŠã¯ãã¡ãã¬ã³ããšãã¬
ã³ãããªã¡ãã¬ã³ãã¡ãã«ã¡ãã¬ã³ããšããã¡ã
ã¬ã³ãïŒâã¡ãã«ããªã¡ãã¬ã³ãïŒïŒïŒâãžã¡ã
ã«ããªã¡ãã¬ã³ãïŒâã¡ã¿ã«ããªã¡ãã¬ã³ããã
ã©ã¡ãã¬ã³ããã³ã¿ã¡ãã¬ã³ããããµã¡ãã¬ã³ãª
ã©ã®ççŽ æ°ïŒãïŒåã®çŽéãŸãã¯åæéã¢ã«ãã¬
ã³åºãæããããã ããšãã«äœçŽã¢ã«ãã«ãšããŠã¯ããã®ã¢ã«ãã«
éšåãççŽ æ°ïŒãïŒåã®çŽéãŸãã¯åæéã¢ã«ã
ã«ã§ããããšãã«ã¢ã«ãã«ãäŸãã°ãã³ãžã«ãïŒ
âããšãã«ãšãã«ãïŒâããšãã«ãšãã«ãïŒâã
ãšãã«ãããã«ãïŒâããšãã«ããã«ãïŒïŒïŒâ
ãžã¡ãã«âïŒâããšãã«ãšãã«ãïŒâããšãã«ã
ã³ãã«ãïŒâããšãã«ããã·ã«ãïŒâã¡ãã«âïŒ
âããšãã«ãããã«ãªã©ãæããããã·ã¯ãã¢ã«
ãã«ãšããŠã¯ççŽ æ°ïŒãïŒåã®ã·ã¯ãã¢ã«ãã«ã
äŸãã°ã·ã¯ããããã«ãã·ã¯ãããã«ãã·ã¯ãã
ã³ãã«ãã·ã¯ãããã·ã«ãã·ã¯ããããã«ãã·ã¯
ããªã¯ãã«ãªã©ãæããããã äœçŽã¢ã«ã³ãã·ãšããŠã¯ççŽ æ°ïŒãïŒåã®çŽé
ãŸãã¯åæéã¢ã«ã³ãã·ãäŸãã°ã¡ããã·ããšã
ãã·ãããããã·ãã€ãœããããã·ããããã·ã
tertâãããã·ããã³ãã«ãªãã·ãããã·ã«ãªã
ã·ãªã©ãæããããããã²ã³ååãšããŠã¯ãã
çŽ ãå¡©çŽ ãèçŽ ããã³ãšãŠçŽ ãæããããã ããšãã«ç°äžã«çœ®æåºãšããŠããã²ã³ååãäœ
åã¢ã«ãã«ãäœçŽã¢ã«ã³ãã·ãæ°Žé žåºããããã
ãã³ã¢ããããéžã°ããåºãïŒãïŒåæããããš
ã®ããããšãã«ãšããŠã¯ãäŸãã°ããšãã«ãïŒ
âãïŒâãŸãã¯ïŒâã¯ããããšãã«ãïŒâãïŒâ
ãŸãã¯ïŒâãã«ãªãããšãã«ãïŒâãïŒâãŸãã¯
ïŒâããã¢ããšãã«ãïŒâãïŒâãŸãã¯ïŒâãšãŒ
ãããšãã«ãïŒïŒïŒâãžã¯ããããšãã«ãïŒïŒïŒ
âãžã¯ããããšãã«ãïŒïŒïŒâãžã¯ããããšã
ã«ãïŒïŒïŒâãžãã«ãªãããšãã«ãïŒïŒïŒâãžã
ãã¢ããšãã«ãïŒâãïŒâãŸãã¯ïŒâã¡ãã«ããš
ãã«ãïŒâãïŒâãŸãã¯ïŒâãšãã«ããšãã«ãïŒ
âãããã«ããšãã«ãïŒâã€ãœãããã«ããšã
ã«ãïŒâããã«ããšãã«ãïŒâããã·ã«ããšã
ã«ãïŒâãã³ãã«ããšãã«ãïŒâtertâããã«ã
ãšãã«ãïŒïŒïŒâãžã¡ãã«ããšãã«ãïŒïŒïŒâãž
ã¡ãã«ããšãã«ãïŒâãïŒâãŸãã¯ïŒâã¡ããã·
ããšãã«ãïŒâãïŒâãŸãã¯ïŒâãšããã·ããšã
ã«ãïŒâããããã·ããšãã«ãïŒâã€ãœãããã
ã·ããšãã«ãïŒâãããã·ããšãã«ãïŒâãã³ã
ã«ãªãã·ããšãã«ãïŒâtertâãããã·ããšã
ã«ãïŒâããã·ã«ãªãã·ããšãã«ãïŒïŒïŒâãžã¡
ããã·ããšãã«ãïŒïŒïŒâãžãšããã·ããšãã«ã
ïŒïŒïŒâãžã¡ããã·ããšãã«ãïŒâãïŒâãŸãã¯
ïŒâãããããšãã«ãïŒïŒïŒâãžãããããšã
ã«ãïŒâãïŒâãŸãã¯ïŒâã¢ããããšãã«ãïŒïŒ
ïŒâãžã¢ããããšãã«ãïŒâã¡ãã«âïŒâã¯ãã
ããšãã«ãïŒâã¯ããâïŒâã¡ãã«ããšãã«ãïŒ
âã¡ããã·âïŒâã¯ããããšãã«ãïŒïŒïŒïŒïŒâ
ããªã¡ããã·ããšãã«ãïŒïŒïŒïŒïŒâããªã¡ãã«
ããšãã«ãïŒïŒïŒïŒïŒâããªã¯ããããšãã«ãïŒ
âãïŒâãŸãã¯ïŒâããããã·ããšãã«ãïŒïŒïŒ
âãžããããã·ããšãã«ãïŒïŒïŒâãžããããã·
ããšãã«ãªã©ã®ããšãã«ç°äžã«çœ®æåºãšããŠãã
ã²ã³ååãççŽ æ°ïŒãïŒåã®ã¢ã«ãã«åºãççŽ æ°
ïŒãïŒåã®ã¢ã«ã³ãã·åºãæ°Žé žåºããããåºãã
ã³ã¢ããåºããéžã°ããåºãïŒãïŒåæããããš
ã®ããããšãã«åºãæããããã ããšãã«ç°äžã«ããã²ã³ååãæããããšã®ã
ãããšãã«äœçŽã¢ã«ãã«åºãšããŠã¯ã眮æåºã®ãª
ãå Žåã¯åèšã®ããšãã«äœçŽã¢ã«ãã«åºãæãã
ãã眮æåºã®ããå Žåã¯ãäŸãã°ïŒâãïŒâãŸã
ã¯ïŒâã¯ãããã³ãžã«ãïŒâãïŒâãŸãã¯ïŒâã
ã«ãªããã³ãžã«ãïŒâãïŒâãŸãã¯ïŒâããã¢ã
ã³ãžã«ãïŒâãïŒâãŸãã¯ïŒâãšãŒããã³ãžã«ã
ïŒïŒïŒâãžã¯ãããã³ãžã«ãïŒïŒïŒâãžã¯ããã
ã³ãžã«ãïŒïŒïŒâãžã¯ãããã³ãžã«ãïŒïŒïŒâãž
ãã«ãªããã³ãžã«ãïŒïŒïŒâãžããã¢ãã³ãžã«ã
ïŒïŒïŒïŒïŒâããªã¯ãããã³ãžã«ãïŒâïŒïŒâã¯
ããããšãã«ïŒãšãã«ãïŒâïŒïŒïŒïŒâãžããã¢
ããšãã«ïŒãšãã«ãïŒâïŒïŒâãšãŒãããšãã«ïŒ
ãšãã«ãïŒâïŒïŒâããã¢ããšãã«ïŒãšãã«ãïŒ
âïŒïŒïŒïŒâãžã¯ããããšãã«ïŒãšãã«ãïŒâïŒïŒ
âã¯ããããšãã«ïŒãšãã«ãïŒâïŒïŒâãã«ãªã
ããšãã«ïŒãããã«ãïŒâïŒïŒïŒïŒïŒïŒâããªã¯
ããããšãã«ïŒãããã«ãïŒâïŒïŒâã¯ããããš
ãã«ïŒããã«ãïŒïŒïŒâãžã¡ãã«âïŒâïŒïŒâã
ãã¢ããšãã«ïŒãšãã«ãïŒâïŒïŒïŒïŒâãžã¯ãã
ããšãã«ïŒãã³ãã«ãïŒâïŒïŒâãšãŒãããšãã«ïŒ
ãã³ãã«ãïŒâïŒïŒâãã«ãªãããšãã«ïŒããã·
ã«ãïŒâïŒïŒïŒïŒâãžã¯ããããšãã«ïŒããã·ã«ã
ïŒâã¡ãã«âïŒâïŒïŒâã¯ããããšãã«ïŒããã
ã«ãªã©ã®ããšãã«ç°äžã®çœ®æåºãšããŠããã²ã³å
åïŒãïŒåãæãããã€ã¢ã«ãã«éšåã®ççŽ æ°ïŒ
ãïŒåã®ããšãã«ã¢ã«ãã«åºãæããããã ã·ã¯ãã¢ã«ãã«ç°äžã«çœ®æåºãšããŠãŸãã¯ã¢ã
ãäœçŽã¢ã«ãã«åºãæããããšã®ããã·ã¯ãã¢ã«
ãã«åºãšããŠã¯ã眮æåºã®ãªãå Žåã¯åèšã®ããš
ãã·ã¯ãã¢ã«ãã«åºãæãããã眮æåºãæãã
å Žåã¯ãïŒâã¢ããã¡ãã«ã·ã¯ããããã«ãïŒâ
ïŒïŒâã¢ãããšãã«ïŒã·ã¯ãããã«ãïŒâïŒïŒâã¢
ãããšãã«ïŒã·ã¯ããã³ãã«ãïŒâïŒïŒâã¢ãã
ãããã«ïŒã·ã¯ãããã·ã«ãïŒâïŒïŒâã¢ããã
ãã«ïŒã·ã¯ãããã·ã«ãïŒâã¢ããã¡ãã«ã·ã¯ã
ããã·ã«ãïŒâïŒïŒâã¢ãããã³ãã«ïŒã·ã¯ãã
ããã«ãïŒâïŒïŒâã¢ããããã·ã«ïŒã·ã¯ããªã¯
ãã«åºçã®åèšããã¢ããåºãççŽ æ°ïŒãïŒã®ã·
ã¯ãã¢ã«ãã«ç°äžã«çœ®æãã眮æã¢ã«ãã«åºãæ
ããããã äœçŽã¢ã«ã³ãã·ã«ã«ããã«åºãšããŠã¯ã¢ã«ã³ã
ã·éšåãççŽ æ°ïŒãïŒåã®çŽéãŸãã¯åæéã®ã¢
ã«ã³ãã·ã«ã«ããã«ãäŸãã°ãã¡ããã·ã«ã«ãã
ã«ããšããã·ã«ã«ããã«ãããããã·ã«ã«ãã
ã«ãã€ãœããããã·ã«ã«ããã«ããããã·ã«ã«ã
ãã«ãtertâãããã·ã«ã«ããã«ããã³ãã«ãªã
ã·ã«ã«ããã«ãããã·ã«ãªãã·ã«ã«ããã«ãªã©ã
æããããã ã¢ããäœçŽã¢ã«ãã«åºãšããŠã¯ããã®ã¢ã«ãã«
éšåãççŽ æ°ïŒãïŒåã®çŽéãŸãã¯åæéã¢ã«ã
ã«ã§ããã¢ããã¢ã«ãã«ãäŸãã°ã¢ããã¡ãã«ã
ïŒâã¢ãããšãã«ãïŒâã¢ãããšãã«ãïŒâã¢ã
ããããã«ãïŒâã¢ããããã«ãïŒïŒïŒâãžã¡ã
ã«âïŒâã¢ãããšãã«ãïŒâã¢ãããã³ãã«ãïŒ
âã¢ããããã·ã«ãïŒâã¡ãã«âïŒâã¢ãããã
ãã«ãªã©ãæããããã 眮æã·ã¯ãã¢ã«ãã«äœçŽã¢ã«ãã«ã¢ããåºïŒè©²
ã·ã¯ãã¢ã«ãã«ç°äžã®çœ®æåºã¯ãã«ã«ããã·åºãŸ
ãã¯æµçŽã¢ã«ã³ãã·ã«ã«ããã«åºã§ããïŒãšããŠ
ã¯ãã¢ã«ãã«éšåãççŽ æ°ïŒãïŒåã®çŽéãŸãã¯
åæéã¢ã«ãã«ã§ãã€ãŠãã·ã¯ãã¢ã«ãã«éšåã
眮æåºãæããççŽ æ°ïŒãïŒåã®ã·ã¯ãã¢ã«ãã«
ïŒè©²ã·ã¯ãã¢ã«ãã«ç°äžã®çœ®æåºã¯ã«ã«ããã·ã«
ãŸãã¯ã¢ã«ã³ãã·ã«éšåãççŽ æ°ïŒãïŒåã®ã¢ã«
ã³ãã·ã«ã«ããã«åºã§ããïŒã§ãã€ãŠãäŸãã°ã
ã¢ãããã·ã¯ããããã«ã¡ãã«ã¢ãããïŒâã·ã¯
ãããã«ãšãã«ã¢ãããïŒâã·ã¯ããã³ãã«ãšã
ã«ã¢ãããïŒâã·ã¯ãããã·ã«ãããã«ã¢ããã
ïŒâã·ã¯ããããã«ããã«ã¢ãããïŒâã·ã¯ããª
ã¯ãã«ãã³ãã«ã¢ãããïŒâã·ã¯ãããã·ã«ãã
ã·ã«ã¢ãããã·ã¯ãããã·ã«ã¡ãã«ã¢ãããïŒâ
ã¡ãã«âïŒâã·ã¯ãããã·ã«ãããã«ã¢ããã
ïŒïŒâã«ã«ããã·ã·ã¯ããããã«ïŒã¡ãã«ã¢ããã
ïŒâïŒïŒâã«ã«ããã·ã·ã¯ãããã«ïŒãšãã«ã¢ã
ããïŒâïŒïŒâã«ã«ããã·ã·ã¯ããã³ãã«ïŒãšã
ã«ã¢ãããïŒâïŒïŒâã«ã«ããã·ã·ã¯ããã³ãã«ïŒ
ãããã«ã¢ãããïŒâïŒïŒâã«ã«ããã·ã·ã¯ãã
ãã·ã«ïŒããã«ã¢ãããïŒâïŒïŒâã«ã«ããã·ã·
ã¯ãããã·ã«ïŒãã³ãã«ã¢ãããïŒâïŒïŒâã«ã«
ããã·ã·ã¯ãããã·ã«ïŒããã·ã«ã¢ãããïŒïŒâ
ã«ã«ããã·ã·ã¯ããããã«ïŒã¡ãã«ã¢ãããïŒâ
ïŒïŒâã«ã«ããã·ã·ã¯ããããã«ïŒãšãã«ã¢ããã
ïŒâïŒïŒâã«ã«ããã·ã·ã¯ããããã«ïŒãšãã«ã¢
ãããïŒâïŒïŒâã«ã«ããã·ã·ã¯ããªã¯ãã«ïŒã
ããã«ã¢ãããïŒâïŒïŒâã«ã«ããã·ã·ã¯ããªã¯
ãã«ïŒããã«ã¢ãããïŒïŒâã«ã«ããã·ã·ã¯ãã
ãã·ã«ïŒã¡ãã«ã¢ãããïŒâïŒïŒâã¡ããã·ã«ã«
ããã«ã·ã¯ããããã«ïŒããã·ã«ã¢ãããïŒâ
ïŒïŒâãšããã·ã«ã«ããã«ã·ã¯ãããã«ïŒãã³ã
ã«ã¢ãããïŒâïŒïŒâããããã·ã«ã«ããã«ã·ã¯
ããã³ãã«ïŒããã«ã¢ãããïŒâïŒïŒâã¡ããã·
ã«ã«ããã«ã·ã¯ãããã·ã«ïŒãããã«ã¢ãããïŒ
âïŒïŒâïœâãããã·ã«ã«ããã«ã·ã¯ãããã·ã«ïŒ
ãšãã«ã¢ãããïŒâïŒïŒâããã·ã«ãªãã·ã«ã«ã
ãã«ã·ã¯ãããã·ã«ïŒãšãã«ã¢ãããïŒïŒâãšã
ãã·ã«ã«ããã«ã·ã¯ãããã·ã«ïŒã¡ãã«ã¢ããã
ïŒâã¡ãã«âïŒâïŒïŒâããããã·ã«ã«ããã«ã·
ã¯ããããã«ïŒãããã«ã¢ãããïŒïŒâã¡ããã·
ã«ã«ããã«ã·ã¯ããªã¯ãã«ïŒã¡ãã«ã¢ãããïŒïŒ
âã¡ããã·ã«ã«ããã«ã·ã¯ãããã·ã«ïŒã¡ãã«ã¢
ãããªã©ãæããããã 眮æåºãšããŠããã²ã³ååãæããããšãã«ã¹
ã«ããã«åºãšããŠã¯ãäŸãã°ãïŒâãïŒâãŸãã¯
ïŒâã¯ããããšãã«ã¹ã«ããã«ãïŒâãïŒâãŸã
ã¯ïŒâããã¢ããšãã«ã¹ã«ããã«ãïŒâãïŒâãŸ
ãã¯ïŒâãšãŒãããšãã«ã¹ã«ããã«ãªã©ãæãã
ããšãã§ããã ããã²ã³ååãšããŠã¯ãåŒçŽ ååãå¡©çŽ ååã
èçŽ ååãæ²çŽ ååãªã©ãäŸç€ºã§ããã æ¬çºæã®ååç©ã¯å åŠç°æ§äœãååšããããã
ãæ¬çºæã«å«ãŸããã æ¬çºæã®ååç©ã¯åçš®ã®æ¹æ³ã§è£œé ã§ããäŸã
ã°äžèšåå¿åŒâã«ç€ºãæ¹æ³ã«ãã補é ã§ããã
ãã€ãã®çœ®æåºã®çœ®æäœçœ®ã¯ã«ã«ãã¹ããªã«éªšæ Œ
ã®ïŒïŒïŒïŒïŒãŸãã¯ïŒäœã®ããããã§ããããŸã
ã«ã«ãã¹ããªã«éªšæ Œã®ïŒäœãšïŒäœéã®çµåã¯äžé
çµåãŸãã¯äºéçµåã瀺ãã ã§ç€ºãããã«ã«ãã¹ããªã«èªå°äœãŸãã¯ãã®å¡©ã
掻æ§æåãšããŠå«æããããšãç¹åŸŽãšããæ朰ç
å€ã«é¢ããã æ¬çºæã®ååç©ã¯æ朰çäœçšãæããäŸãã°è
朰çãåäºæè žæœ°çãªã©ã®æ¶ååšç³»ã®æœ°çã®æ²»ç
å€ãšããŠæçšã§ãããæ¬çºæã®ååç©ã¯ããšã
ã«ãå®éšé ¢é žæœ°çãçŒçŒæœ°çãªã©ã®æ ¢æ§æœ°çç æ
ã«å¯ŸããŠé¡èãªäºé²ããã³æ²»çå¹æãæããç¹ã«
ç¹åŸŽãããããããæ¯æ§ããã³å¯äœçšã匱ããæ ¢
æ§æœ°çã«å¯ŸããŠæå¹ãªè¬å€ã§ãããæ¬çºæã®åå
ç©ã¯ãŸããå å æ§ããã¹ã¿ã°ã©ã³ãžã³E2éãå¢
å ãããäœçšãæããããã¹ã¿ã°ã©ã³ãžã³E2ã«
ç±æ¥ããè¬å¹ãäŸãã°ã朰çã®äºé²ããã³æ²»çè¬
ãªã©ãšããŠæçšã§ããã æ¬æ现æžã«ãããŠãäœçŽã¢ã«ãã«ãšããŠã¯ççŽ
æ°ïŒãïŒåã®çŽéãŸãã¯åæéã¢ã«ãã«ãäŸãã°
ã¡ãã«ããšãã«ããããã«ãã€ãœãããã«ããã
ã«ãã€ãœããã«ããã³ãã«ãããã·ã«ãªã©ãæã
ãããäœçŽã¢ã«ã±ãã«ãšããŠã¯ççŽ æ°ïŒãïŒåã®
çŽéãŸãã¯åæéã¢ã«ã±ãã«ãäŸãã°ããã«ãã¢
ãªã«ãïŒâãããã«ãïŒâãããã«ãïŒâã¡ãã«
ã¢ãªã«ãïŒâãã³ããã«ãïŒâããã»ãã«ãªã©ã
ããã«äœçŽã¢ã«ããã«ãšããŠã¯ççŽ æ°ïŒãïŒåã®
çŽéãŸãã¯åæéã¢ã«ããã«ãäŸãã°ãšããã«ã
ïŒâããããã«ãïŒâãããã«ãïŒâãããã«ã
ïŒâã¡ãã«âïŒâããããã«ãïŒâãã³ããã«ã
ïŒâããã·ãã«ãªã©ãæããããã äœçŽã¢ã«ãã¬ã³åºãšããŠã¯ãã¡ãã¬ã³ããšãã¬
ã³ãããªã¡ãã¬ã³ãã¡ãã«ã¡ãã¬ã³ããšããã¡ã
ã¬ã³ãïŒâã¡ãã«ããªã¡ãã¬ã³ãïŒïŒïŒâãžã¡ã
ã«ããªã¡ãã¬ã³ãïŒâã¡ã¿ã«ããªã¡ãã¬ã³ããã
ã©ã¡ãã¬ã³ããã³ã¿ã¡ãã¬ã³ããããµã¡ãã¬ã³ãª
ã©ã®ççŽ æ°ïŒãïŒåã®çŽéãŸãã¯åæéã¢ã«ãã¬
ã³åºãæããããã ããšãã«äœçŽã¢ã«ãã«ãšããŠã¯ããã®ã¢ã«ãã«
éšåãççŽ æ°ïŒãïŒåã®çŽéãŸãã¯åæéã¢ã«ã
ã«ã§ããããšãã«ã¢ã«ãã«ãäŸãã°ãã³ãžã«ãïŒ
âããšãã«ãšãã«ãïŒâããšãã«ãšãã«ãïŒâã
ãšãã«ãããã«ãïŒâããšãã«ããã«ãïŒïŒïŒâ
ãžã¡ãã«âïŒâããšãã«ãšãã«ãïŒâããšãã«ã
ã³ãã«ãïŒâããšãã«ããã·ã«ãïŒâã¡ãã«âïŒ
âããšãã«ãããã«ãªã©ãæããããã·ã¯ãã¢ã«
ãã«ãšããŠã¯ççŽ æ°ïŒãïŒåã®ã·ã¯ãã¢ã«ãã«ã
äŸãã°ã·ã¯ããããã«ãã·ã¯ãããã«ãã·ã¯ãã
ã³ãã«ãã·ã¯ãããã·ã«ãã·ã¯ããããã«ãã·ã¯
ããªã¯ãã«ãªã©ãæããããã äœçŽã¢ã«ã³ãã·ãšããŠã¯ççŽ æ°ïŒãïŒåã®çŽé
ãŸãã¯åæéã¢ã«ã³ãã·ãäŸãã°ã¡ããã·ããšã
ãã·ãããããã·ãã€ãœããããã·ããããã·ã
tertâãããã·ããã³ãã«ãªãã·ãããã·ã«ãªã
ã·ãªã©ãæããããããã²ã³ååãšããŠã¯ãã
çŽ ãå¡©çŽ ãèçŽ ããã³ãšãŠçŽ ãæããããã ããšãã«ç°äžã«çœ®æåºãšããŠããã²ã³ååãäœ
åã¢ã«ãã«ãäœçŽã¢ã«ã³ãã·ãæ°Žé žåºããããã
ãã³ã¢ããããéžã°ããåºãïŒãïŒåæããããš
ã®ããããšãã«ãšããŠã¯ãäŸãã°ããšãã«ãïŒ
âãïŒâãŸãã¯ïŒâã¯ããããšãã«ãïŒâãïŒâ
ãŸãã¯ïŒâãã«ãªãããšãã«ãïŒâãïŒâãŸãã¯
ïŒâããã¢ããšãã«ãïŒâãïŒâãŸãã¯ïŒâãšãŒ
ãããšãã«ãïŒïŒïŒâãžã¯ããããšãã«ãïŒïŒïŒ
âãžã¯ããããšãã«ãïŒïŒïŒâãžã¯ããããšã
ã«ãïŒïŒïŒâãžãã«ãªãããšãã«ãïŒïŒïŒâãžã
ãã¢ããšãã«ãïŒâãïŒâãŸãã¯ïŒâã¡ãã«ããš
ãã«ãïŒâãïŒâãŸãã¯ïŒâãšãã«ããšãã«ãïŒ
âãããã«ããšãã«ãïŒâã€ãœãããã«ããšã
ã«ãïŒâããã«ããšãã«ãïŒâããã·ã«ããšã
ã«ãïŒâãã³ãã«ããšãã«ãïŒâtertâããã«ã
ãšãã«ãïŒïŒïŒâãžã¡ãã«ããšãã«ãïŒïŒïŒâãž
ã¡ãã«ããšãã«ãïŒâãïŒâãŸãã¯ïŒâã¡ããã·
ããšãã«ãïŒâãïŒâãŸãã¯ïŒâãšããã·ããšã
ã«ãïŒâããããã·ããšãã«ãïŒâã€ãœãããã
ã·ããšãã«ãïŒâãããã·ããšãã«ãïŒâãã³ã
ã«ãªãã·ããšãã«ãïŒâtertâãããã·ããšã
ã«ãïŒâããã·ã«ãªãã·ããšãã«ãïŒïŒïŒâãžã¡
ããã·ããšãã«ãïŒïŒïŒâãžãšããã·ããšãã«ã
ïŒïŒïŒâãžã¡ããã·ããšãã«ãïŒâãïŒâãŸãã¯
ïŒâãããããšãã«ãïŒïŒïŒâãžãããããšã
ã«ãïŒâãïŒâãŸãã¯ïŒâã¢ããããšãã«ãïŒïŒ
ïŒâãžã¢ããããšãã«ãïŒâã¡ãã«âïŒâã¯ãã
ããšãã«ãïŒâã¯ããâïŒâã¡ãã«ããšãã«ãïŒ
âã¡ããã·âïŒâã¯ããããšãã«ãïŒïŒïŒïŒïŒâ
ããªã¡ããã·ããšãã«ãïŒïŒïŒïŒïŒâããªã¡ãã«
ããšãã«ãïŒïŒïŒïŒïŒâããªã¯ããããšãã«ãïŒ
âãïŒâãŸãã¯ïŒâããããã·ããšãã«ãïŒïŒïŒ
âãžããããã·ããšãã«ãïŒïŒïŒâãžããããã·
ããšãã«ãªã©ã®ããšãã«ç°äžã«çœ®æåºãšããŠãã
ã²ã³ååãççŽ æ°ïŒãïŒåã®ã¢ã«ãã«åºãççŽ æ°
ïŒãïŒåã®ã¢ã«ã³ãã·åºãæ°Žé žåºããããåºãã
ã³ã¢ããåºããéžã°ããåºãïŒãïŒåæããããš
ã®ããããšãã«åºãæããããã ããšãã«ç°äžã«ããã²ã³ååãæããããšã®ã
ãããšãã«äœçŽã¢ã«ãã«åºãšããŠã¯ã眮æåºã®ãª
ãå Žåã¯åèšã®ããšãã«äœçŽã¢ã«ãã«åºãæãã
ãã眮æåºã®ããå Žåã¯ãäŸãã°ïŒâãïŒâãŸã
ã¯ïŒâã¯ãããã³ãžã«ãïŒâãïŒâãŸãã¯ïŒâã
ã«ãªããã³ãžã«ãïŒâãïŒâãŸãã¯ïŒâããã¢ã
ã³ãžã«ãïŒâãïŒâãŸãã¯ïŒâãšãŒããã³ãžã«ã
ïŒïŒïŒâãžã¯ãããã³ãžã«ãïŒïŒïŒâãžã¯ããã
ã³ãžã«ãïŒïŒïŒâãžã¯ãããã³ãžã«ãïŒïŒïŒâãž
ãã«ãªããã³ãžã«ãïŒïŒïŒâãžããã¢ãã³ãžã«ã
ïŒïŒïŒïŒïŒâããªã¯ãããã³ãžã«ãïŒâïŒïŒâã¯
ããããšãã«ïŒãšãã«ãïŒâïŒïŒïŒïŒâãžããã¢
ããšãã«ïŒãšãã«ãïŒâïŒïŒâãšãŒãããšãã«ïŒ
ãšãã«ãïŒâïŒïŒâããã¢ããšãã«ïŒãšãã«ãïŒ
âïŒïŒïŒïŒâãžã¯ããããšãã«ïŒãšãã«ãïŒâïŒïŒ
âã¯ããããšãã«ïŒãšãã«ãïŒâïŒïŒâãã«ãªã
ããšãã«ïŒãããã«ãïŒâïŒïŒïŒïŒïŒïŒâããªã¯
ããããšãã«ïŒãããã«ãïŒâïŒïŒâã¯ããããš
ãã«ïŒããã«ãïŒïŒïŒâãžã¡ãã«âïŒâïŒïŒâã
ãã¢ããšãã«ïŒãšãã«ãïŒâïŒïŒïŒïŒâãžã¯ãã
ããšãã«ïŒãã³ãã«ãïŒâïŒïŒâãšãŒãããšãã«ïŒ
ãã³ãã«ãïŒâïŒïŒâãã«ãªãããšãã«ïŒããã·
ã«ãïŒâïŒïŒïŒïŒâãžã¯ããããšãã«ïŒããã·ã«ã
ïŒâã¡ãã«âïŒâïŒïŒâã¯ããããšãã«ïŒããã
ã«ãªã©ã®ããšãã«ç°äžã®çœ®æåºãšããŠããã²ã³å
åïŒãïŒåãæãããã€ã¢ã«ãã«éšåã®ççŽ æ°ïŒ
ãïŒåã®ããšãã«ã¢ã«ãã«åºãæããããã ã·ã¯ãã¢ã«ãã«ç°äžã«çœ®æåºãšããŠãŸãã¯ã¢ã
ãäœçŽã¢ã«ãã«åºãæããããšã®ããã·ã¯ãã¢ã«
ãã«åºãšããŠã¯ã眮æåºã®ãªãå Žåã¯åèšã®ããš
ãã·ã¯ãã¢ã«ãã«åºãæãããã眮æåºãæãã
å Žåã¯ãïŒâã¢ããã¡ãã«ã·ã¯ããããã«ãïŒâ
ïŒïŒâã¢ãããšãã«ïŒã·ã¯ãããã«ãïŒâïŒïŒâã¢
ãããšãã«ïŒã·ã¯ããã³ãã«ãïŒâïŒïŒâã¢ãã
ãããã«ïŒã·ã¯ãããã·ã«ãïŒâïŒïŒâã¢ããã
ãã«ïŒã·ã¯ãããã·ã«ãïŒâã¢ããã¡ãã«ã·ã¯ã
ããã·ã«ãïŒâïŒïŒâã¢ãããã³ãã«ïŒã·ã¯ãã
ããã«ãïŒâïŒïŒâã¢ããããã·ã«ïŒã·ã¯ããªã¯
ãã«åºçã®åèšããã¢ããåºãççŽ æ°ïŒãïŒã®ã·
ã¯ãã¢ã«ãã«ç°äžã«çœ®æãã眮æã¢ã«ãã«åºãæ
ããããã äœçŽã¢ã«ã³ãã·ã«ã«ããã«åºãšããŠã¯ã¢ã«ã³ã
ã·éšåãççŽ æ°ïŒãïŒåã®çŽéãŸãã¯åæéã®ã¢
ã«ã³ãã·ã«ã«ããã«ãäŸãã°ãã¡ããã·ã«ã«ãã
ã«ããšããã·ã«ã«ããã«ãããããã·ã«ã«ãã
ã«ãã€ãœããããã·ã«ã«ããã«ããããã·ã«ã«ã
ãã«ãtertâãããã·ã«ã«ããã«ããã³ãã«ãªã
ã·ã«ã«ããã«ãããã·ã«ãªãã·ã«ã«ããã«ãªã©ã
æããããã ã¢ããäœçŽã¢ã«ãã«åºãšããŠã¯ããã®ã¢ã«ãã«
éšåãççŽ æ°ïŒãïŒåã®çŽéãŸãã¯åæéã¢ã«ã
ã«ã§ããã¢ããã¢ã«ãã«ãäŸãã°ã¢ããã¡ãã«ã
ïŒâã¢ãããšãã«ãïŒâã¢ãããšãã«ãïŒâã¢ã
ããããã«ãïŒâã¢ããããã«ãïŒïŒïŒâãžã¡ã
ã«âïŒâã¢ãããšãã«ãïŒâã¢ãããã³ãã«ãïŒ
âã¢ããããã·ã«ãïŒâã¡ãã«âïŒâã¢ãããã
ãã«ãªã©ãæããããã 眮æã·ã¯ãã¢ã«ãã«äœçŽã¢ã«ãã«ã¢ããåºïŒè©²
ã·ã¯ãã¢ã«ãã«ç°äžã®çœ®æåºã¯ãã«ã«ããã·åºãŸ
ãã¯æµçŽã¢ã«ã³ãã·ã«ã«ããã«åºã§ããïŒãšããŠ
ã¯ãã¢ã«ãã«éšåãççŽ æ°ïŒãïŒåã®çŽéãŸãã¯
åæéã¢ã«ãã«ã§ãã€ãŠãã·ã¯ãã¢ã«ãã«éšåã
眮æåºãæããççŽ æ°ïŒãïŒåã®ã·ã¯ãã¢ã«ãã«
ïŒè©²ã·ã¯ãã¢ã«ãã«ç°äžã®çœ®æåºã¯ã«ã«ããã·ã«
ãŸãã¯ã¢ã«ã³ãã·ã«éšåãççŽ æ°ïŒãïŒåã®ã¢ã«
ã³ãã·ã«ã«ããã«åºã§ããïŒã§ãã€ãŠãäŸãã°ã
ã¢ãããã·ã¯ããããã«ã¡ãã«ã¢ãããïŒâã·ã¯
ãããã«ãšãã«ã¢ãããïŒâã·ã¯ããã³ãã«ãšã
ã«ã¢ãããïŒâã·ã¯ãããã·ã«ãããã«ã¢ããã
ïŒâã·ã¯ããããã«ããã«ã¢ãããïŒâã·ã¯ããª
ã¯ãã«ãã³ãã«ã¢ãããïŒâã·ã¯ãããã·ã«ãã
ã·ã«ã¢ãããã·ã¯ãããã·ã«ã¡ãã«ã¢ãããïŒâ
ã¡ãã«âïŒâã·ã¯ãããã·ã«ãããã«ã¢ããã
ïŒïŒâã«ã«ããã·ã·ã¯ããããã«ïŒã¡ãã«ã¢ããã
ïŒâïŒïŒâã«ã«ããã·ã·ã¯ãããã«ïŒãšãã«ã¢ã
ããïŒâïŒïŒâã«ã«ããã·ã·ã¯ããã³ãã«ïŒãšã
ã«ã¢ãããïŒâïŒïŒâã«ã«ããã·ã·ã¯ããã³ãã«ïŒ
ãããã«ã¢ãããïŒâïŒïŒâã«ã«ããã·ã·ã¯ãã
ãã·ã«ïŒããã«ã¢ãããïŒâïŒïŒâã«ã«ããã·ã·
ã¯ãããã·ã«ïŒãã³ãã«ã¢ãããïŒâïŒïŒâã«ã«
ããã·ã·ã¯ãããã·ã«ïŒããã·ã«ã¢ãããïŒïŒâ
ã«ã«ããã·ã·ã¯ããããã«ïŒã¡ãã«ã¢ãããïŒâ
ïŒïŒâã«ã«ããã·ã·ã¯ããããã«ïŒãšãã«ã¢ããã
ïŒâïŒïŒâã«ã«ããã·ã·ã¯ããããã«ïŒãšãã«ã¢
ãããïŒâïŒïŒâã«ã«ããã·ã·ã¯ããªã¯ãã«ïŒã
ããã«ã¢ãããïŒâïŒïŒâã«ã«ããã·ã·ã¯ããªã¯
ãã«ïŒããã«ã¢ãããïŒïŒâã«ã«ããã·ã·ã¯ãã
ãã·ã«ïŒã¡ãã«ã¢ãããïŒâïŒïŒâã¡ããã·ã«ã«
ããã«ã·ã¯ããããã«ïŒããã·ã«ã¢ãããïŒâ
ïŒïŒâãšããã·ã«ã«ããã«ã·ã¯ãããã«ïŒãã³ã
ã«ã¢ãããïŒâïŒïŒâããããã·ã«ã«ããã«ã·ã¯
ããã³ãã«ïŒããã«ã¢ãããïŒâïŒïŒâã¡ããã·
ã«ã«ããã«ã·ã¯ãããã·ã«ïŒãããã«ã¢ãããïŒ
âïŒïŒâïœâãããã·ã«ã«ããã«ã·ã¯ãããã·ã«ïŒ
ãšãã«ã¢ãããïŒâïŒïŒâããã·ã«ãªãã·ã«ã«ã
ãã«ã·ã¯ãããã·ã«ïŒãšãã«ã¢ãããïŒïŒâãšã
ãã·ã«ã«ããã«ã·ã¯ãããã·ã«ïŒã¡ãã«ã¢ããã
ïŒâã¡ãã«âïŒâïŒïŒâããããã·ã«ã«ããã«ã·
ã¯ããããã«ïŒãããã«ã¢ãããïŒïŒâã¡ããã·
ã«ã«ããã«ã·ã¯ããªã¯ãã«ïŒã¡ãã«ã¢ãããïŒïŒ
âã¡ããã·ã«ã«ããã«ã·ã¯ãããã·ã«ïŒã¡ãã«ã¢
ãããªã©ãæããããã 眮æåºãšããŠããã²ã³ååãæããããšãã«ã¹
ã«ããã«åºãšããŠã¯ãäŸãã°ãïŒâãïŒâãŸãã¯
ïŒâã¯ããããšãã«ã¹ã«ããã«ãïŒâãïŒâãŸã
ã¯ïŒâããã¢ããšãã«ã¹ã«ããã«ãïŒâãïŒâãŸ
ãã¯ïŒâãšãŒãããšãã«ã¹ã«ããã«ãªã©ãæãã
ããšãã§ããã ããã²ã³ååãšããŠã¯ãåŒçŽ ååãå¡©çŽ ååã
èçŽ ååãæ²çŽ ååãªã©ãäŸç€ºã§ããã æ¬çºæã®ååç©ã¯å åŠç°æ§äœãååšããããã
ãæ¬çºæã«å«ãŸããã æ¬çºæã®ååç©ã¯åçš®ã®æ¹æ³ã§è£œé ã§ããäŸã
ã°äžèšåå¿åŒâã«ç€ºãæ¹æ³ã«ãã補é ã§ããã
ãè¡šã
ãåŒäžãR1ïŒR2ïŒR6ïŒïŒ¡ïŒïœããã³ã«ã«ãã¹
ããªã«éªšæ žã®ïŒäœãšïŒäœéã®çµåã¯åèšãšåãã
R3â²ã¯äœçŽã¢ã«ã³ãã·ãäœçŽã¢ã«ã³ãã·ã«ã«ãã
ã«äœçŽã¢ã«ã³ãã·ããã³ãŸã€ã«äœçŽã¢ã«ã³ãã·ãŸ
ãã¯äœçŽã¢ã«ã«ãã€ã«ãªãã·äœçŽã¢ã«ã³ãã·ã
R3â³ã¯ã¢ããåºãŸãã¯ã·ã¯ãã¢ã«ãã«äœçŽã¢ã«ã
ã«ã¢ããåºïŒè©²ã·ã¯ãã¢ã«ãã«ç°ã«ã«ã«ããã·ãŸ
ãã¯äœçŽã¢ã«ã³ãã·ã«ã«ããã«ã眮æããŠããŠã
ããïŒãR4â²ã¯çœ®æåºãšããŠäœçŽã¢ã«ãã«ãŸãã¯ã
ãã²ã³ååãæããããšã®ããããšãã«ã¹ã«ãã
ã«ãäœçŽã¢ã«ãã«ãŸãã¯ããšãã«ç°äžã«çœ®æåºãš
ããŠããã²ã³ååãæããããšã®ããããšãã«äœ
çŽã¢ã«ãã«ãR7ããã³R9ã¯ããããäœçŽã¢ã«ã
ã«ãR8ã¯äœçŽã¢ã«ã«ãã€ã«ã瀺ãã ããªãã¡ãåŒ(2)ã®ååç©ãå æ°Žå解ããææã«
ãããã®çæç©ãã¢ã·ã«åããšã¹ãã«åããŸãã¯
ãããã®çµåãã«ããç®çã®ã«ã«ãã¹ããªã«èªå°
äœã«å°ãã ãã®ååç©ïŒãå æ°Žå解ããŠæ¬çºæã®ååç©ã®
ïŒã€ã§ããåŒïŒ1aïŒã®ååç©ã«å°ãåå¿ã¯ãé©
åœãªå æ°Žå解觊åªãäŸãã°å¡©é žãèåæ°ŽçŽ é žãªã©
ã®ããã²ã³åæ°ŽçŽ é žãç¡«é žãçé žãªã©ã®ç¡æ©é žã
æ°Žé žåãããªãŠã ãæ°Žé žåã«ãªãŠã ãªã©ã®ã¢ã«ã«
ãªéå±æ°Žé žåç©ãçé žãããªãŠã ãçé žã«ãªãŠ
ã ãçé žæ°ŽçŽ ãããªãŠã ãªã©ã®ã¢ã«ã«ãªéå±çé ž
å¡©ãŸãã¯éçé žå¡©ãªã©ã®ç¡æ©ã¢ã«ã«ãªååç©ã®å
åšäžã«ãç¡æº¶åªãŸãã¯é©åœãªæº¶åªäžïŒäŸãã°ãæ°Ž
ãŸãã¯æ°Žãšã¡ã¿ããŒã«ããšã¿ããŒã«ãªã©ã®äœçŽã¢
ã«ã³ãŒã«ãšã®æ··å溶åªïŒã50ã150âã奜ãŸããã¯
70ã100âã«ãŠãïŒã24æéçšåºŠåŠçããã°ããã ååç©1aïŒ1cãŸãã¯1lãåŒ(3)ã®ã«ã«ãã³é žãçš
ããŠã¢ã·ã«åããããšã«ãããããã察å¿ããä»
ã®ç®çååç©1bïŒ1dãŸãã¯1mã«å°ãããšãã§ã
ããããã®ã¢ã·ã«åã¯éåžžã®ã¢ããçµåçæåå¿
ã«ä»ãããšã«ããéæãããããã®å Žåã該ã«ã«
ãã³é žïŒã¯æŽ»æ§åãããååç©ãçšããŠãããã ã¢ããçµåçæåå¿ãšããŠã¢ããçµåçæåå¿
ã®æ¡ä»¶ãé©çšããããšãåºæ¥ããäŸãã°(ã€)æ··åé ž
ç¡æ°Žç©æ³ãããªãã¡ã«ã«ãã³é žïŒã«ã¢ã«ãã«ãã
ã«ã«ãã³é žãåå¿ãããŠæ··åé žç¡æ°Žç©ãšãããã
ã«ååç©1aïŒ1cãŸãã¯1lãåå¿ãããæ¹æ³ã(ã)掻
æ§ãšã¹ãã«æ³ãŸãã¯æŽ»æ§ã¢ããæ³ãããªãã¡ã«ã«
ãã³é žïŒãäŸãã°ïœâãããããšãã«ãšã¹ãã«ã
âããããã·ã³ãã¯é žã€ãããšã¹ãã«ãïŒâã
ãããã·ãã³ãŸããªã¢ãŸãŒã«ãšã¹ãã«ãªã©ã®æŽ»æ§
ãšã¹ãã«ããŸãã¯ãã³ãºãªããµãŸãªã³âïŒâããª
ã³ãšã®æŽ»æ§ã¢ãããšããããã«ååç©1aïŒ1cãŸ
ãã¯1lãåå¿ãããæ¹æ³ã(ã)ã«ã«ããžã€ããæ³ã
ããªãã¡ã«ã«ãã³é žïŒã«ååç©1aïŒ1cãŸãã¯1lã
äŸãã°ãžã·ã¯ãããã·ã«ã«ã«ããžã€ãããã«ã«ã
ãã«ãžã€ãããŸãŒã«ãªã©ã®è±æ°Žå€ã®ååšäžã«è±æ°Ž
çµåãããæ¹æ³ã(ã)ã«ã«ãã³é žãã©ã€ãæ³ãããª
ãã¡ã«ã«ãã³é žïŒããã©ã€ãäœã«èªå°ããããã«
ååç©1aïŒ1cãŸãã¯1lãåå¿ãããæ¹æ³ã(ã)ãã®
ä»ã®æ¹æ³ãšããŠã«ã«ãã³é žïŒãäŸãã°ç¡æ°Žé ¢é žãª
ã©ã®è±æ°Žå€ã«ãããã«ã«ãã³é žç¡æ°Žç©ãšãããã
ã«ååç©1aïŒ1cãŸãã¯1lãåå¿ãããæ¹æ³ãã«ã«
ãã³é žïŒãšäŸãã°äœçŽã¢ã«ã³ãŒã«ãšã®ãšã¹ãã«ã«
ååç©1aïŒ1cãŸãã¯1lãé«å§é«æž©äžã«åå¿ããã
æ¹æ³ãªã©ãæããããšãã§ããããŸãã«ã«ãã³é ž
ïŒãããªããšãã«ãã¹ãã€ã³ããžãšãã«ã¯ããã
ã¹ããšãŒããªã©ã®ãªã³ååç©ã§æŽ»æ§åããããã«
ååç©1aïŒ1cãŸãã¯1lãåå¿ãããæ¹æ³ãæ¡çšã
ããããæ··åé žç¡æ°Žç©æ³ã«ãããŠäœ¿çšãããã¢ã«
ãã«ããã«ã«ãã³é žãšããŠã¯ãäŸãã°ã¯ãã«ã®é ž
ã¡ãã«ãããã ã®é žã¡ãã«ãã¯ãã«ã®é žãšãã«ã
ããã ã®é žãšãã«ãã¯ãã«ã®é žã€ãœããã«ãªã©ã
æãããããæ··åé žç¡æ°Žç©ã¯éåžžã®ã·ãšããã³â
ããŠãã³åå¿ã«ããåŸããããããéåžžåé¢ãã
ããšãªãååç©1aïŒ1cãŸãã¯1lãšåå¿ãããããš
ã«ããæ¬çºæååç©1bïŒ1dãŸãã¯1mã補é ãã
ããã·ãšããã³âããŠãã³åå¿ã¯éåžžå¡©åºæ§åå
ç©ã®ååšäžã«è¡ãªããããçšããããå¡©åºæ§åå
ç©ãšããŠã¯ã·ãšããã³âããŠãã³åå¿ã«æ £çšã®å
åç©ãçšããããäŸãã°ãããªãšãã«ã¢ãã³ãã
ãªã¡ãã«ã¢ãã³ãããªãžã³ããžã¡ãã«ã¢ããªã³ã
âã¡ãã«ã¢ã«ããªã³ãïŒâãžã¡ãã«ã¢ããããª
ãžã³ãïŒïŒïŒâãžã¢ã¶ãã·ã¯ãã4.3.0ãããã³
âïŒïŒDBNïŒãïŒïŒïŒâãžã¢ã¶ãã·ã¯ãã5.4.0ã
ãŠã³ãã»ã³âïŒïŒDBUïŒãïŒïŒïŒâãžã¢ã¶ãã·ã¯
ãã2.2.2ããªã¯ã¿ã³ïŒDABCOïŒãªã©ã®ææ©å¡©
åºãçé žã«ãªãŠã ãçé žãããªãŠã ãçé žæ°ŽçŽ ã«
ãªãŠã ãçé žæ°ŽçŽ ãããªãŠã ãªã©ã®ç¡æ©å¡©åºãã
ããããã該åå¿ã¯â20ã100âçšåºŠã奜ãŸãã
ã¯ïŒã50âã«ãããŠè¡ãªãããåå¿æéã¯ïŒåã
10æéçšåºŠã奜ãŸããã¯ïŒåãïŒæéã§ãããåŸ
ãããæ··åé žç¡æ°Žç©ãšååç©1aïŒ1cãŸãã¯1lãšã®
åå¿ã¯â20âã150âçšåºŠã奜ãŸããã¯10ã50â
ã«ãŠïŒåã10æéçšåºŠã奜ãŸããã¯ïŒåãïŒæé
çšåºŠè¡ãªããããæ··åé žç¡æ°Žç©æ³ã¯ç¹ã«æº¶åªãçš
ããªããŠãããããäžè¬ã«æº¶åªäžã§è¡ããããçš
ãããã溶åªã¯æ··åé žç¡æ°Žç©æ³ã«æ £çšã®æº¶åªãã
ããã䜿çšå¯èœã§ãããå ·äœçã«ã¯å¡©åã¡ãã¬
ã³ãã¯ãããã«ã ããžã¯ãã«ãšã¿ã³ãªã©ã®ããã²
ã³åççŽ é¡ããã³ãŒã³ããã«ãšã³ããã·ã¬ã³ãªã©
ã®è³éŠæçåæ°ŽçŽ é¡ããžãšãã«ãšãŒãã«ãããã©
ããããã©ã³ããžã¡ããã·ãšã¿ã³ãªã©ã®ãšãŒãã«
é¡ãé ¢é žã¡ãã«ãé ¢é žãšãã«ãªã©ã®ãšã¹ãã«é¡ã
ãžã¡ãã«ãã«ã ã¢ããããžã¡ãã«ã¹ã«ããã·ãã
ãããµã¡ãã«ãªã³é žããªã¢ãããªã©ã®éãããã³
æ§æ¥µæ§æº¶åªãªã©ãæããããã該æ³ã«ãããã«ã«
ãã³é žïŒãã¢ã«ãã«ããã«ã«ãã³é žããã³ååç©
1aïŒ1cãŸãã¯1lã®äœ¿çšå²åã¯éåžžå°ããšãåœã¢ã«
ã¥ã€äœ¿çšãããããã«ã«ãã³é žïŒã«å¯ŸããŠã¢ã«ã
ã«ããã«ã«ãã³é žããã³ååç©1aïŒ1cãŸãã¯1lã
ïŒãïŒåã¢ã«çšããã®ã奜ãŸããã äžèš(ã)ã®æŽ»æ§ãšã¹ãã«æ³ãŸãã¯æŽ»æ§ã¢ããæ³
ã¯ãäŸãã°ãã³ãºãªããµãŸãªã³âïŒâããªã³ã¢ã
ããçšããå ŽåãäŸã«ãšãã°ãåå¿ã«åœ±é¿ãäžã
ãªãé©åœãªæº¶åªãäŸãã°äžèšæ··åé žç¡æ°Žç©æ³ã«çš
ãããã®ãšåæ§ã®æº¶åªã®ã»ãïŒâã¡ãã«âïŒâã
ããªãã³ãªã©ãçšããïŒã150âã奜ãŸããã¯10
ã100âã«ãŠã0.5ã75æéåå¿ãããããšã«ãã
è¡ãªãããããã®å Žåãååç©1aïŒ1cãŸãã¯1lãš
ãã³ãºãªããµãŸãªã³âïŒâããªã³ã¢ãããšã®äœ¿çš
å²åã¯ãåè ã«å¯ŸããŠåŸè ãéåžžå°ãªããšãçã¢
ã«ã奜ãŸããã¯çã¢ã«ãïŒåã¢ã«ãšããã ãŸãâããããã·ã³ãã¯é žã€ãããšã¹ãã«ã
çšããå Žåã¯ãé©åœãªå¡©åºãäŸãã°åŸèšã«ã«ãã³
é žãã©ã€ãæ³ã«çšãããããã®ãšåæ§ã®å¡©åºãçš
ãããšåå¿ã¯æå©ã«é²è¡ããã äžèš(ã)ã®ã«ã«ãã³é žãã©ã€ãæ³ã¯ãã«ã«ãã³é ž
ïŒã«ããã²ã³åå€ãåå¿ãããŠãã«ã«ãã³é žãã©
ã€ããšãããã®ã«ã«ãã³é žãã©ã€ããåé¢ç²Ÿè£œ
ãããŸãã¯åé¢ç²Ÿè£œããããšãªããããã«ååç©
1aïŒ1cãŸãã¯1lãåå¿ãããŠè¡ãªãããã ãã®ã«ã«ãã³é žãã©ã€ããšååç©1aïŒ1cãŸã
ã¯1lãšã®åå¿ã¯è±ããã²ã³åæ°ŽçŽ å€ã®ååšäžã«é©
åœãªæº¶åªäžã§è¡ãªããããè±ããã²ã³åæ°ŽçŽ å€ãš
ããŠã¯éåžžå¡©åºæ§ååç©ãçšããããäžèšã·ãšã
ãã³âããŠãã³åå¿ã«çšããããå¡©åºååç©ã®
ã»ãæ°Žé žåãããªãŠã ãæ°Žé žåã«ãªãŠã ãæ°ŽçŽ å
ãããªãŠã ãæ°ŽçŽ åã«ãªãŠã ãçé žéããããªãŠ
ã ã¡ãã©ãŒãããããªãŠã ãšãã©ãŒããªã©ã®ã¢ã«
ã«ãªéå±ã¢ã«ã³ã©ãŒããªã©ãæããããããªãå
å¿ååç©ã®ååç©1aïŒ1cãŸãã¯1lãéå°éçšããŠ
è±ããã²ã³åæ°ŽçŽ å€ãšããŠå Œçšãããããšãã§ã
ãã溶åªãšããŠã¯åèšã·ãšããã³âããŠãã³åå¿
ã«çšãããã溶åªã®ã»ããäŸãã°æ°Žãã¡ã¿ããŒ
ã«ããšã¿ããŒã«ããããããŒã«ããã¿ããŒã«ãïŒ
âã¡ããã·âïŒâãã¿ããŒã«ããšãã«ã»ããœã«
ããã¡ãã«ã»ããœã«ããªã©ã®ã¢ã«ã³ãŒã«é¡ãããª
ãžã³ãã¢ã»ãã³ãã¢ã»ããããªã«ãªã©ããŸãã¯ã
ããã®ïŒçš®ä»¥äžã®æ··å溶åªãæãããããååç©
1aïŒ1cãŸãã¯1lãšã«ã«ãã³é žãã©ã€ããšã®äœ¿çšå²
åã¯ç¹ã«éå®ãããåºç¯å²ã«éžæãããããéåžž
åè ã«å¯ŸããŠåŸè ãå°ãªããšãçã¢ã«ã奜ãŸãã
ã¯çã¢ã«ãïŒåã¢ã«çšãããããåå¿æž©åºŠã¯éåžž
â30ã180âçšåºŠã奜ãŸããã¯çŽïŒã150âã§ãäž
è¬ã«ïŒåã30æéã§åå¿ã¯å®çµããã çšããããã«ã«ãã³é žãã©ã€ãã¯ãã«ã«ãã³é ž
ïŒãšããã²ã³åå€ãšãç¡æº¶åªãŸãã¯æº¶åªäžã«ãŠå
å¿ãããŠè£œé ãããã溶åªãšããŠã¯ãåå¿ã«æªåœ±
é¿ãäžããªããã®ã§ããã°äœ¿çšã§ããäŸãã°ãã³
ãŒã³ããã«ãšã³ããã·ã¬ã³ãªã©ã®è³éŠæçåæ°ŽçŽ
é¡ãã¯ãããã«ã ãå¡©åã¡ãã¬ã³ãåå¡©åççŽ ãª
ã©ã®ããã²ã³åçåæ°ŽçŽ é¡ããžãªããµã³ãããã©
ããããã©ã³ããžãšãã«ãšãŒãã«ãªã©ã®ãšãŒãã«
é¡ããžã¡ãã«ãã«ã ã¢ããããžã¡ãã«ã¹ã«ããã·
ããªã©ãæãããããããã²ã³åå€ãšããŠã¯ãã«
ã«ããã·åºã®æ°Žé žåºãããã²ã³ã«å€ãããéåžžã®
ããã²ã³åå€ã䜿çšã§ããäŸãã°å¡©åããªãã«ã
ãªãã·å¡©åãªã³ããªãã·èåãªã³ãäºå¡©åãªã³ã
äºèåãªã³ãªã©ãäŸç€ºãããã ã«ã«ãã³é žïŒãšããã²ã³åå€ãšã®äœ¿çšå²åã¯ãš
ãã«éå®ãããé©å®éžæãããããç¡æº¶åªäžã§å
å¿ãè¡ãå Žåã«ã¯ãéåžžåè ã«å¯ŸããŠãåŸè ã倧
éå°éããŸã溶åªäžã§åå¿ãè¡ãå Žåã«ã¯ãéåžž
åè ã«å¯ŸããŠåŸè ãå°ãªããšãçã¢ã«éçšåºŠã奜
ãŸããã¯ãïŒãïŒåã¢ã«éãçšããããã®åå¿æž©
床ããã³åå¿æéããšãã«éå®ãããªãããéåžž
宀枩ã100âçšåºŠã奜ãŸããã¯50ã80âã«ãŠã30
åéãïŒæéçšåºŠã§è¡ãªãããã ãŸãã«ã«ãã³é žïŒãããªããšãã«ãã¹ãã€ã³ã
ãžãšãã«ã¯ãããã¹ããšãŒããªã©ã®ãªã³ååç©ã§
掻æ§åããããã«ååç©1aïŒ1cãŸãã¯1lãåå¿ã
ããæ¹æ³ã¯ãé©åœãªæº¶åªäžã§è¡ãªãããã溶åªãš
ããŠã¯åå¿ã«åœ±é¿ãäžããªããã®ãªãã°äœãã䜿
çšããããšãã§ããå ·äœçã«ã¯å¡©åã¡ãã¬ã³ãã¯
ãããã«ã ããžã¯ãã«ãšã¿ã³ãªã©ã®ããã²ã³åç
çŽ é¡ããã³ãŒã³ããã«ãšã³ããã·ã¬ã³ãªã©ã®è³éŠ
æçåæ°ŽçŽ é¡ããžãšãã«ãšãŒãã«ãããã©ããã
ãã©ã³ããžã¡ããã·ãšã¿ã³ãªã©ã®ãšãŒãã«é¡ãé ¢
é žã¡ãã«ãé ¢é žãšãã«ãªã©ã®ãšã¹ãã«é¡ããžã¡ã
ã«ãã«ã ã¢ããããžã¡ãã«ã¹ã«ããã·ãããããµ
ã¡ãã«ãªã³é žããªã¢ãããªã©ã®éãããã³æ§æ¥µæ§
溶åªãªã©ãæããããã該åå¿ã§ã¯ååç©1aïŒ
1cãŸãã¯1lèªäœãå¡©åºæ§ååç©ãšããŠåãããã
ãããçè«éããéå°ã«çšããããšã«ãã€ãŠåå¿
ã¯è¯å¥œã«é²è¡ããããå¿ èŠã«å¿ããŠãä»ã®å¡©åºæ§
ååç©ãäŸãã°ãããªãšãã«ã¢ãã³ãããªã¡ãã«
ã¢ãã³ãããªãžã³ããžã¡ãã«ã¢ããªã³ãâã¡ã
ã«ã¢ã«ããªã³ãïŒâãžã¡ãã«ã¢ããããªãžã³ã
ïŒïŒïŒâãžã¢ã¶ãã·ã¯ãã4.3.0ãããã³âïŒ
ïŒDBNïŒãïŒïŒïŒâãžã¢ã¶ãã·ã¯ãã5.4.0ããŠã³
ãã»ã³âïŒïŒDBUïŒãïŒïŒïŒâãžã¢ã¶ãã·ã¯ã
ã2.2.2ããªã¯ã¿ã³ïŒDABCOïŒãªã©ã®ææ©å¡©åºã
çé žã«ãªãŠã ãçé žãããªãŠã ãçé žæ°ŽçŽ ã«ãªãŠ
ã ãçé žæ°ŽçŽ ãããªãŠã ãªã©ã®ç¡æ©å¡©åºãçšãã
ããšãã§ããã該åå¿ã¯çŽïŒã150âã奜ãŸãã
ã¯çŽïŒã100âã§ãçŽïŒã30æéè¡ãªãããšã«ã
ãéæããããååç©1aïŒ1cãŸãã¯1lã«å¯Ÿãããª
ã³ååç©ããã³ã«ã«ãã³é žïŒã®äœ¿çšå²åã¯ããã
ãããéåžžå°ãªããšãçã¢ã«éçšåºŠã奜ãŸããã¯
ïŒãïŒåã¢ã«éã§ããã åèšåå¿åŒâã«ãããŠãååç©1aãŸãã¯1b
ãåŒ(4)ã®ã¢ã«ã³ãŒã«ãçšããŠãšã¹ãã«åããããš
ã«ãããããã察å¿ããç®çååç©1cãŸãã¯1d
ã«å°ãããšãã§ããã ãã®ãšã¹ãã«ååå¿ã¯éåžžã®ãšã¹ãã«ååå¿ã®
åå¿æ¡ä»¶ãããããæ¡çšãããäŸãã°(1)溶åªäžè±
æ°Žå€ã®ååšäžã«è±æ°Žçž®åããããã(2)é žæ§ãŸãã¯
å¡©åºæ§è§Šåªã®ååšäžã«é©åœãªæº¶åªäžã§åå¿ãã
ãã(1)ã®æ¹æ³ã§äœ¿çšããã溶åªãšããŠã¯ãäŸãã°
å¡©åã¡ãã¬ã³ãã¯ãããã«ã ããžã¯ãã«ãšã¿ã³ãª
ã©ã®ããã²ã³åççŽ é¡ããã³ãŒã³ããã«ãšã³ãã
ã·ã¬ã³ãªã©ã®è³éŠæçåæ°ŽçŽ é¡ããžãšãã«ãšãŒã
ã«ãããã©ããããã©ã³ããžã¡ããã·ãšã¿ã³ãªã©
ã®ãšãŒãã«é¡ããžã¡ãã«ãã«ã ã¢ããããžã¡ãã«
ã¹ã«ããã·ãããããµã¡ãã«ãªã³é žããªã¢ãããª
ã©ã®éãããã³æ§æ¥µæ§æº¶åªãªã©ãæããããããŸ
ãè±æ°Žå€ãšããŠã¯ãäŸãã°ãžã·ã¯ãããã·ã«ã«ã«
ããžã€ãããã«ã«ããã«ãžã€ãããŸãŒã«ãªã©ãäŸ
瀺ã§ãããååç©1aãŸãã¯1bã«å¯Ÿããã¢ã«ã³ãŒ
ã«ïŒã®äœ¿çšå²åã¯å°ãªããšãçã¢ã«ã奜ãŸããã¯
çã¢ã«ã1.5åã¢ã«ã§ãããè±æ°Žå€ã®äœ¿çšå²åã¯
ååç©1aãŸãã¯1bã«å¯ŸããŠå°ãªããšãçã¢ã«ã
奜ãŸããã¯çã¢ã«ã1.5åã¢ã«ã§ãããåå¿æž©åºŠ
ã¯é垞宀枩ã150âã奜ãŸããã¯50ã100âã§ã該
åå¿ã¯äžè¬ã«ïŒã10æéã§çµäºããã (2)ã®æ¹æ³ã§çšããããé žæ§è§ŠåªãšããŠã¯ãäŸã
ã°å¡©é žã¬ã¹ãæ¿ç¡«é žããªã³é žãããªãªã³é žãäžã
ãåããŠçŽ ãéå¡©çŽ é žãªã©ã®ç¡æ©é žãããªããã
é ¢é žãããªãããã¡ã¿ã³ã¹ã«ãã³é žãããã¿ã¬ã³
ã¹ã«ãã³é žãïœâãã·ã«é žããã³ãŒã³ã¹ã«ãã³
é žããšã¿ã³ã¹ã«ãã³é žãªã©ã®ææ©é žãããªã¯ãã
ã¡ã¿ã³ã¹ã«ãã³é žç¡æ°Žç©ãããªãããã¡ã¿ã³ã¹ã«
ãã³é žç¡æ°Žç©ãªã©ã®é žç¡æ°Žç©ãå¡©åããªãã«ãã¢
ã»ãã³ãžã¡ãã«ã¢ã»ã¿ãŒã«ãªã©ãäŸç€ºã§ãããã
ãã«é žæ§ã€ãªã³äº€ææš¹èãæ¬çºæã®è§ŠåªãšããŠçš
ããããšãã§ãããå¡©åºæ§è§ŠåªãšããŠã¯å ¬ç¥ã®ã
ã®ãåºã䜿çšã§ããäŸãã°ãæ°Žé žåãããªãŠã ã
æ°Žé žåã«ãªãŠã ãçé žãããªãŠã ãçé žã«ãªãŠ
ã ãçé žæ°ŽçŽ ãããªãŠã ãçé žæ°ŽçŽ ã«ãªãŠã ãç
é žéãªã©ã®ç¡æ©å¡©åºããããªãŠã ã¡ãã©ãŒããã
ããªãŠã ãšãã©ãŒããªã©ã®ã¢ã«ã³ã©ãŒããæãã
ãããæ¬åå¿ã¯ç¡æº¶åªãããã¯æº¶åªäžã®ãããã§
ãé²è¡ãããçšãããã溶åªãšããŠã¯ãéåžžã®ãš
ã¹ãã«ååå¿ã«äœ¿çšããã溶åªãæå¹ã«äœ¿çšã§
ããå ·äœçã«ã¯ãã³ãŒã³ããã«ãšã³ããã·ã¬ã³ãª
ã©ã®è³éŠæçåæ°ŽçŽ é¡ããžã¯ããã¡ã¿ã³ããžã¯ã
ããšã¿ã³ãã¯ãããã«ã ãåå¡©åççŽ ãªã©ã®ãã
ã²ã³åçåæ°ŽçŽ é¡ããžãšãã«ãšãŒãã«ãããã©ã
ãããã©ã³ããžãªããµã³ããšãã¬ã³ã°ãªã³ãŒã«ã¢
ãã¡ãã«ãšãŒãã«ãªã©ã®ãšãŒãã«é¡ãæããã
ããããã«äžèšåå¿ã¯ç¡æ°Žå¡©åã«ã«ã·ãŠã ãç¡æ°Ž
ç¡«é žé ãç¡æ°Žç¡«é žã«ã«ã·ãŠã ãäºé žåãªã³ãªã©ã®
也ç¥å€ã®äœ¿çšã«ããæå©ã«è¡ãªãããã該åå¿ã«
ãããååç©1aãŸãã¯1bãšã¢ã«ã³ãŒã«ïŒãšã®äœ¿
çšå²åã¯ç¹ã«éå®ãããåºãç¯å²ããé©å®éžæã§
ããããç¡æº¶åªã®å Žåã¯åè ã«å¯ŸããŠåŸè ã倧é
å°ã«çšãã溶åªãçšããå Žåã«ã¯åè ã«å¯ŸããŠåŸ
è ãçã¢ã«ãïŒåã¢ã«ã奜ãŸããã¯çã¢ã«ãïŒå
ã¢ã«çšãããåå¿æž©åºŠã¯ç¹ã«éå®ãããªãããé
åžžâ20ã200âçšåºŠã奜ãŸããã¯ïŒã150âçšåºŠã§
ãããåå¿æéã¯éåžžïŒã20æéçšåºŠã§ããã ãªããåèšåå¿åŒâã«ãããŠãåŒïŒ1bïŒïŒ
ïŒ1cïŒïŒïŒ1dïŒïŒïŒ1nïŒïŒïŒ1lïŒãŸãã¯ïŒ1mïŒã®ååç©
ãå æ°Žå解ããŠåŒïŒ1aïŒã®ååç©ã«å°ãããšã
ã§ãããã®å æ°Žå解ã¯ååç©ïŒã®å æ°Žå解ã®å Žå
ãšåæ§ã®æ¡ä»¶ãæ¡çšããããã ååç©1aãŸãã¯1bã®ã¢ããååå¿ã¯ãåèšå
åç©1aïŒ1cãŸãã¯1lã®ã¢ããçµåçæåå¿ãšåæ§
ã®æ¡ä»¶ã§è¡ãªãããšãã§ããã ååç©1aïŒ1cãŸãã¯1lãšååç©ïŒãšã®åå¿ã¯ç¡
溶åªãŸãã¯éåžžã®äžæŽ»æ§æº¶åªäžã§ã宀枩ã200â
çšåºŠã奜ãŸããã¯å®€æž©ã120âã®æž©åºŠæ¡ä»¶äžãæ°
æéã24æéçšåºŠè¡ãªããããäžæŽ»æ§æº¶åªãšããŠ
ã¯ãäŸãã°ãžãªããµã³ãããã©ããããã©ã³ããš
ãã¬ã³ã°ãªã³ãŒã«ãžã¡ãã«ãšãŒãã«ããžãšãã«ãš
ãŒãã«ãªã©ã®ãšãŒãã«é¡ããã³ãŒã³ããã«ãšã³ã
ãã·ã¬ã³ãªã©ã®è³éŠæçåæ°ŽçŽ é¡ãã¡ã¿ããŒã«ã
ãšã¿ããŒã«ãã€ãœãããããŒã«ãªã©ã®äœçŽã¢ã«ã³
ãŒã«é¡ããžã¡ãã«ãã«ã ã¢ããããžã¡ãã«ã¹ã«ã
ãã·ãããããµã¡ãã«ãªã³é žããªã¢ãããã¢ã»ã
ã³ãã¢ã»ããããªã«ãªã©ã®æ¥µæ§æº¶åªãçšããã
ããäžèšåå¿ã¯ãããæå©ã«ã¯ãå¡©åºæ§ååç©ã
è±é žå€ãšããŠçšããŠè¡ãªãããã該塩åºæ§ååç©
ãšããŠã¯ãäŸãã°çé žã«ãªãŠã ãçé žãããªãŠ
ã ãæ°Žé žåãããªãŠã ãçé žæ°ŽçŽ ãããªãŠã ãã
ããªãŠã ã¢ãããæ°ŽçŽ åãããªãŠã ãªã©ã®ã¢ã«ã«
ãªéå±ååç©ãããªãšãã«ã¢ãã³ãããªãããã«
ã¢ãã³ãããªãžã³ããããªã³ãªã©ã®ç¬¬äžçŽã¢ãã³
é¡ãäŸç€ºãããããŸãäžèšåå¿ã¯ãå¿ èŠã«å¿ããŠ
åå¿ä¿é²å€ãšããŠããšãŠåã«ãªãŠã ããšãŠåãã
ãªãŠã ãªã©ã®ãšãŠåã¢ã«ã«ãªéå±ååç©ãŸãã¯ã
ããµã¡ãã«ãªã³é žããªã¢ãããæ·»å ããŠè¡ãªãåŸ
ããäžèšåå¿ã«ãããååç©1aïŒ1cãŸãã¯1lãšå
åç©ïŒãšã®äœ¿çšå²åã¯ãšãã«éå®ãããªãããé
åžžãåè ã«å¯ŸããŠåŸè ãçã¢ã«ãéå°éã奜ãŸã
ãã¯çã¢ã«ãïŒåã¢ã«ã§ããã äžèšååç©1aïŒ1cãŸãã¯1lãšååç©ïŒãšã®åå¿
ã§åŸãããååç©ïŒïœïŒïŒïœãŸãã¯ïŒïœãåæ§ã®
æ¡ä»¶äžã«ããã«ã¹ã«ããã«åããŠäžè¬åŒ K0012 ãåŒäžãR1ïŒR2ïŒR3ïŒR4â²ïŒïŒ¡ããã³ïœã¯åèš
ãšåããR5â²ã¯çœ®æåºãšããŠäœçŽã¢ã«ãã«åºãŸã
ã¯ããã²ã³ååãæããããšã®ããããšãã«ã¹ã«
ããã«åºã瀺ãã ã§ç€ºãããååç©ã«å°ãããšãã§ããã ãŸãåŒ(1)ã®ååç©äžãR4ã眮æåºãšããŠäœçŽ
ã¢ã«ãã«ãŸãã¯ããã²ã³ååãæããããšã®ãã
ããšãã«ã¹ã«ããã«åºã§ããå Žåã¯ãååç©1a
ãšååç©ïŒãšã®åå¿ãšåæ§ã®æ¡ä»¶äžã«ã¢ã·ã«åã
ãŠäžè¬åŒ K0013 ãåŒäžãR1ïŒR2ïŒR3ïŒR5â²ïŒR6ïŒïŒ¡ããã³ïœã¯
åèšãšåãã ã§ç€ºãããååç©ã«å°ãããšãã§ããã ããã«ãåèšååç©ïŒïœã¯ãç¡«é žãå¡©é žãèå
æ°ŽçŽ é žãªã©ã®é±é žã®ååšäžã«ãæ°Žãã¡ã¿ããŒã«ã
ãšã¿ããŒã«ãã€ãœãããããŒã«ãªã©ã®äœçŽã¢ã«ã³
ãŒã«é¡ããŸãã¯æ°ŽãšäœçŽã¢ã«ã³ãŒã«é¡ãšã®æ··å溶
åªäžãéåžžã宀枩ã150âã奜ãŸããã¯60ã120â
ã«ãŠ30åã150æéçšåºŠåå¿ãããããšã«ããäž
è¬åŒïŒ1oïŒã®ååç©ã«å°ãããšãã§ããã æ¬çºæã®ååç©ã¯ãäžèšåå¿åŒâã«ç€ºãæ¹æ³
ã«ãã€ãŠã補é ã§ããã
ããªã«éªšæ žã®ïŒäœãšïŒäœéã®çµåã¯åèšãšåãã
R3â²ã¯äœçŽã¢ã«ã³ãã·ãäœçŽã¢ã«ã³ãã·ã«ã«ãã
ã«äœçŽã¢ã«ã³ãã·ããã³ãŸã€ã«äœçŽã¢ã«ã³ãã·ãŸ
ãã¯äœçŽã¢ã«ã«ãã€ã«ãªãã·äœçŽã¢ã«ã³ãã·ã
R3â³ã¯ã¢ããåºãŸãã¯ã·ã¯ãã¢ã«ãã«äœçŽã¢ã«ã
ã«ã¢ããåºïŒè©²ã·ã¯ãã¢ã«ãã«ç°ã«ã«ã«ããã·ãŸ
ãã¯äœçŽã¢ã«ã³ãã·ã«ã«ããã«ã眮æããŠããŠã
ããïŒãR4â²ã¯çœ®æåºãšããŠäœçŽã¢ã«ãã«ãŸãã¯ã
ãã²ã³ååãæããããšã®ããããšãã«ã¹ã«ãã
ã«ãäœçŽã¢ã«ãã«ãŸãã¯ããšãã«ç°äžã«çœ®æåºãš
ããŠããã²ã³ååãæããããšã®ããããšãã«äœ
çŽã¢ã«ãã«ãR7ããã³R9ã¯ããããäœçŽã¢ã«ã
ã«ãR8ã¯äœçŽã¢ã«ã«ãã€ã«ã瀺ãã ããªãã¡ãåŒ(2)ã®ååç©ãå æ°Žå解ããææã«
ãããã®çæç©ãã¢ã·ã«åããšã¹ãã«åããŸãã¯
ãããã®çµåãã«ããç®çã®ã«ã«ãã¹ããªã«èªå°
äœã«å°ãã ãã®ååç©ïŒãå æ°Žå解ããŠæ¬çºæã®ååç©ã®
ïŒã€ã§ããåŒïŒ1aïŒã®ååç©ã«å°ãåå¿ã¯ãé©
åœãªå æ°Žå解觊åªãäŸãã°å¡©é žãèåæ°ŽçŽ é žãªã©
ã®ããã²ã³åæ°ŽçŽ é žãç¡«é žãçé žãªã©ã®ç¡æ©é žã
æ°Žé žåãããªãŠã ãæ°Žé žåã«ãªãŠã ãªã©ã®ã¢ã«ã«
ãªéå±æ°Žé žåç©ãçé žãããªãŠã ãçé žã«ãªãŠ
ã ãçé žæ°ŽçŽ ãããªãŠã ãªã©ã®ã¢ã«ã«ãªéå±çé ž
å¡©ãŸãã¯éçé žå¡©ãªã©ã®ç¡æ©ã¢ã«ã«ãªååç©ã®å
åšäžã«ãç¡æº¶åªãŸãã¯é©åœãªæº¶åªäžïŒäŸãã°ãæ°Ž
ãŸãã¯æ°Žãšã¡ã¿ããŒã«ããšã¿ããŒã«ãªã©ã®äœçŽã¢
ã«ã³ãŒã«ãšã®æ··å溶åªïŒã50ã150âã奜ãŸããã¯
70ã100âã«ãŠãïŒã24æéçšåºŠåŠçããã°ããã ååç©1aïŒ1cãŸãã¯1lãåŒ(3)ã®ã«ã«ãã³é žãçš
ããŠã¢ã·ã«åããããšã«ãããããã察å¿ããä»
ã®ç®çååç©1bïŒ1dãŸãã¯1mã«å°ãããšãã§ã
ããããã®ã¢ã·ã«åã¯éåžžã®ã¢ããçµåçæåå¿
ã«ä»ãããšã«ããéæãããããã®å Žåã該ã«ã«
ãã³é žïŒã¯æŽ»æ§åãããååç©ãçšããŠãããã ã¢ããçµåçæåå¿ãšããŠã¢ããçµåçæåå¿
ã®æ¡ä»¶ãé©çšããããšãåºæ¥ããäŸãã°(ã€)æ··åé ž
ç¡æ°Žç©æ³ãããªãã¡ã«ã«ãã³é žïŒã«ã¢ã«ãã«ãã
ã«ã«ãã³é žãåå¿ãããŠæ··åé žç¡æ°Žç©ãšãããã
ã«ååç©1aïŒ1cãŸãã¯1lãåå¿ãããæ¹æ³ã(ã)掻
æ§ãšã¹ãã«æ³ãŸãã¯æŽ»æ§ã¢ããæ³ãããªãã¡ã«ã«
ãã³é žïŒãäŸãã°ïœâãããããšãã«ãšã¹ãã«ã
âããããã·ã³ãã¯é žã€ãããšã¹ãã«ãïŒâã
ãããã·ãã³ãŸããªã¢ãŸãŒã«ãšã¹ãã«ãªã©ã®æŽ»æ§
ãšã¹ãã«ããŸãã¯ãã³ãºãªããµãŸãªã³âïŒâããª
ã³ãšã®æŽ»æ§ã¢ãããšããããã«ååç©1aïŒ1cãŸ
ãã¯1lãåå¿ãããæ¹æ³ã(ã)ã«ã«ããžã€ããæ³ã
ããªãã¡ã«ã«ãã³é žïŒã«ååç©1aïŒ1cãŸãã¯1lã
äŸãã°ãžã·ã¯ãããã·ã«ã«ã«ããžã€ãããã«ã«ã
ãã«ãžã€ãããŸãŒã«ãªã©ã®è±æ°Žå€ã®ååšäžã«è±æ°Ž
çµåãããæ¹æ³ã(ã)ã«ã«ãã³é žãã©ã€ãæ³ãããª
ãã¡ã«ã«ãã³é žïŒããã©ã€ãäœã«èªå°ããããã«
ååç©1aïŒ1cãŸãã¯1lãåå¿ãããæ¹æ³ã(ã)ãã®
ä»ã®æ¹æ³ãšããŠã«ã«ãã³é žïŒãäŸãã°ç¡æ°Žé ¢é žãª
ã©ã®è±æ°Žå€ã«ãããã«ã«ãã³é žç¡æ°Žç©ãšãããã
ã«ååç©1aïŒ1cãŸãã¯1lãåå¿ãããæ¹æ³ãã«ã«
ãã³é žïŒãšäŸãã°äœçŽã¢ã«ã³ãŒã«ãšã®ãšã¹ãã«ã«
ååç©1aïŒ1cãŸãã¯1lãé«å§é«æž©äžã«åå¿ããã
æ¹æ³ãªã©ãæããããšãã§ããããŸãã«ã«ãã³é ž
ïŒãããªããšãã«ãã¹ãã€ã³ããžãšãã«ã¯ããã
ã¹ããšãŒããªã©ã®ãªã³ååç©ã§æŽ»æ§åããããã«
ååç©1aïŒ1cãŸãã¯1lãåå¿ãããæ¹æ³ãæ¡çšã
ããããæ··åé žç¡æ°Žç©æ³ã«ãããŠäœ¿çšãããã¢ã«
ãã«ããã«ã«ãã³é žãšããŠã¯ãäŸãã°ã¯ãã«ã®é ž
ã¡ãã«ãããã ã®é žã¡ãã«ãã¯ãã«ã®é žãšãã«ã
ããã ã®é žãšãã«ãã¯ãã«ã®é žã€ãœããã«ãªã©ã
æãããããæ··åé žç¡æ°Žç©ã¯éåžžã®ã·ãšããã³â
ããŠãã³åå¿ã«ããåŸããããããéåžžåé¢ãã
ããšãªãååç©1aïŒ1cãŸãã¯1lãšåå¿ãããããš
ã«ããæ¬çºæååç©1bïŒ1dãŸãã¯1mã補é ãã
ããã·ãšããã³âããŠãã³åå¿ã¯éåžžå¡©åºæ§åå
ç©ã®ååšäžã«è¡ãªããããçšããããå¡©åºæ§åå
ç©ãšããŠã¯ã·ãšããã³âããŠãã³åå¿ã«æ £çšã®å
åç©ãçšããããäŸãã°ãããªãšãã«ã¢ãã³ãã
ãªã¡ãã«ã¢ãã³ãããªãžã³ããžã¡ãã«ã¢ããªã³ã
âã¡ãã«ã¢ã«ããªã³ãïŒâãžã¡ãã«ã¢ããããª
ãžã³ãïŒïŒïŒâãžã¢ã¶ãã·ã¯ãã4.3.0ãããã³
âïŒïŒDBNïŒãïŒïŒïŒâãžã¢ã¶ãã·ã¯ãã5.4.0ã
ãŠã³ãã»ã³âïŒïŒDBUïŒãïŒïŒïŒâãžã¢ã¶ãã·ã¯
ãã2.2.2ããªã¯ã¿ã³ïŒDABCOïŒãªã©ã®ææ©å¡©
åºãçé žã«ãªãŠã ãçé žãããªãŠã ãçé žæ°ŽçŽ ã«
ãªãŠã ãçé žæ°ŽçŽ ãããªãŠã ãªã©ã®ç¡æ©å¡©åºãã
ããããã該åå¿ã¯â20ã100âçšåºŠã奜ãŸãã
ã¯ïŒã50âã«ãããŠè¡ãªãããåå¿æéã¯ïŒåã
10æéçšåºŠã奜ãŸããã¯ïŒåãïŒæéã§ãããåŸ
ãããæ··åé žç¡æ°Žç©ãšååç©1aïŒ1cãŸãã¯1lãšã®
åå¿ã¯â20âã150âçšåºŠã奜ãŸããã¯10ã50â
ã«ãŠïŒåã10æéçšåºŠã奜ãŸããã¯ïŒåãïŒæé
çšåºŠè¡ãªããããæ··åé žç¡æ°Žç©æ³ã¯ç¹ã«æº¶åªãçš
ããªããŠãããããäžè¬ã«æº¶åªäžã§è¡ããããçš
ãããã溶åªã¯æ··åé žç¡æ°Žç©æ³ã«æ £çšã®æº¶åªãã
ããã䜿çšå¯èœã§ãããå ·äœçã«ã¯å¡©åã¡ãã¬
ã³ãã¯ãããã«ã ããžã¯ãã«ãšã¿ã³ãªã©ã®ããã²
ã³åççŽ é¡ããã³ãŒã³ããã«ãšã³ããã·ã¬ã³ãªã©
ã®è³éŠæçåæ°ŽçŽ é¡ããžãšãã«ãšãŒãã«ãããã©
ããããã©ã³ããžã¡ããã·ãšã¿ã³ãªã©ã®ãšãŒãã«
é¡ãé ¢é žã¡ãã«ãé ¢é žãšãã«ãªã©ã®ãšã¹ãã«é¡ã
ãžã¡ãã«ãã«ã ã¢ããããžã¡ãã«ã¹ã«ããã·ãã
ãããµã¡ãã«ãªã³é žããªã¢ãããªã©ã®éãããã³
æ§æ¥µæ§æº¶åªãªã©ãæããããã該æ³ã«ãããã«ã«
ãã³é žïŒãã¢ã«ãã«ããã«ã«ãã³é žããã³ååç©
1aïŒ1cãŸãã¯1lã®äœ¿çšå²åã¯éåžžå°ããšãåœã¢ã«
ã¥ã€äœ¿çšãããããã«ã«ãã³é žïŒã«å¯ŸããŠã¢ã«ã
ã«ããã«ã«ãã³é žããã³ååç©1aïŒ1cãŸãã¯1lã
ïŒãïŒåã¢ã«çšããã®ã奜ãŸããã äžèš(ã)ã®æŽ»æ§ãšã¹ãã«æ³ãŸãã¯æŽ»æ§ã¢ããæ³
ã¯ãäŸãã°ãã³ãºãªããµãŸãªã³âïŒâããªã³ã¢ã
ããçšããå ŽåãäŸã«ãšãã°ãåå¿ã«åœ±é¿ãäžã
ãªãé©åœãªæº¶åªãäŸãã°äžèšæ··åé žç¡æ°Žç©æ³ã«çš
ãããã®ãšåæ§ã®æº¶åªã®ã»ãïŒâã¡ãã«âïŒâã
ããªãã³ãªã©ãçšããïŒã150âã奜ãŸããã¯10
ã100âã«ãŠã0.5ã75æéåå¿ãããããšã«ãã
è¡ãªãããããã®å Žåãååç©1aïŒ1cãŸãã¯1lãš
ãã³ãºãªããµãŸãªã³âïŒâããªã³ã¢ãããšã®äœ¿çš
å²åã¯ãåè ã«å¯ŸããŠåŸè ãéåžžå°ãªããšãçã¢
ã«ã奜ãŸããã¯çã¢ã«ãïŒåã¢ã«ãšããã ãŸãâããããã·ã³ãã¯é žã€ãããšã¹ãã«ã
çšããå Žåã¯ãé©åœãªå¡©åºãäŸãã°åŸèšã«ã«ãã³
é žãã©ã€ãæ³ã«çšãããããã®ãšåæ§ã®å¡©åºãçš
ãããšåå¿ã¯æå©ã«é²è¡ããã äžèš(ã)ã®ã«ã«ãã³é žãã©ã€ãæ³ã¯ãã«ã«ãã³é ž
ïŒã«ããã²ã³åå€ãåå¿ãããŠãã«ã«ãã³é žãã©
ã€ããšãããã®ã«ã«ãã³é žãã©ã€ããåé¢ç²Ÿè£œ
ãããŸãã¯åé¢ç²Ÿè£œããããšãªããããã«ååç©
1aïŒ1cãŸãã¯1lãåå¿ãããŠè¡ãªãããã ãã®ã«ã«ãã³é žãã©ã€ããšååç©1aïŒ1cãŸã
ã¯1lãšã®åå¿ã¯è±ããã²ã³åæ°ŽçŽ å€ã®ååšäžã«é©
åœãªæº¶åªäžã§è¡ãªããããè±ããã²ã³åæ°ŽçŽ å€ãš
ããŠã¯éåžžå¡©åºæ§ååç©ãçšããããäžèšã·ãšã
ãã³âããŠãã³åå¿ã«çšããããå¡©åºååç©ã®
ã»ãæ°Žé žåãããªãŠã ãæ°Žé žåã«ãªãŠã ãæ°ŽçŽ å
ãããªãŠã ãæ°ŽçŽ åã«ãªãŠã ãçé žéããããªãŠ
ã ã¡ãã©ãŒãããããªãŠã ãšãã©ãŒããªã©ã®ã¢ã«
ã«ãªéå±ã¢ã«ã³ã©ãŒããªã©ãæããããããªãå
å¿ååç©ã®ååç©1aïŒ1cãŸãã¯1lãéå°éçšããŠ
è±ããã²ã³åæ°ŽçŽ å€ãšããŠå Œçšãããããšãã§ã
ãã溶åªãšããŠã¯åèšã·ãšããã³âããŠãã³åå¿
ã«çšãããã溶åªã®ã»ããäŸãã°æ°Žãã¡ã¿ããŒ
ã«ããšã¿ããŒã«ããããããŒã«ããã¿ããŒã«ãïŒ
âã¡ããã·âïŒâãã¿ããŒã«ããšãã«ã»ããœã«
ããã¡ãã«ã»ããœã«ããªã©ã®ã¢ã«ã³ãŒã«é¡ãããª
ãžã³ãã¢ã»ãã³ãã¢ã»ããããªã«ãªã©ããŸãã¯ã
ããã®ïŒçš®ä»¥äžã®æ··å溶åªãæãããããååç©
1aïŒ1cãŸãã¯1lãšã«ã«ãã³é žãã©ã€ããšã®äœ¿çšå²
åã¯ç¹ã«éå®ãããåºç¯å²ã«éžæãããããéåžž
åè ã«å¯ŸããŠåŸè ãå°ãªããšãçã¢ã«ã奜ãŸãã
ã¯çã¢ã«ãïŒåã¢ã«çšãããããåå¿æž©åºŠã¯éåžž
â30ã180âçšåºŠã奜ãŸããã¯çŽïŒã150âã§ãäž
è¬ã«ïŒåã30æéã§åå¿ã¯å®çµããã çšããããã«ã«ãã³é žãã©ã€ãã¯ãã«ã«ãã³é ž
ïŒãšããã²ã³åå€ãšãç¡æº¶åªãŸãã¯æº¶åªäžã«ãŠå
å¿ãããŠè£œé ãããã溶åªãšããŠã¯ãåå¿ã«æªåœ±
é¿ãäžããªããã®ã§ããã°äœ¿çšã§ããäŸãã°ãã³
ãŒã³ããã«ãšã³ããã·ã¬ã³ãªã©ã®è³éŠæçåæ°ŽçŽ
é¡ãã¯ãããã«ã ãå¡©åã¡ãã¬ã³ãåå¡©åççŽ ãª
ã©ã®ããã²ã³åçåæ°ŽçŽ é¡ããžãªããµã³ãããã©
ããããã©ã³ããžãšãã«ãšãŒãã«ãªã©ã®ãšãŒãã«
é¡ããžã¡ãã«ãã«ã ã¢ããããžã¡ãã«ã¹ã«ããã·
ããªã©ãæãããããããã²ã³åå€ãšããŠã¯ãã«
ã«ããã·åºã®æ°Žé žåºãããã²ã³ã«å€ãããéåžžã®
ããã²ã³åå€ã䜿çšã§ããäŸãã°å¡©åããªãã«ã
ãªãã·å¡©åãªã³ããªãã·èåãªã³ãäºå¡©åãªã³ã
äºèåãªã³ãªã©ãäŸç€ºãããã ã«ã«ãã³é žïŒãšããã²ã³åå€ãšã®äœ¿çšå²åã¯ãš
ãã«éå®ãããé©å®éžæãããããç¡æº¶åªäžã§å
å¿ãè¡ãå Žåã«ã¯ãéåžžåè ã«å¯ŸããŠãåŸè ã倧
éå°éããŸã溶åªäžã§åå¿ãè¡ãå Žåã«ã¯ãéåžž
åè ã«å¯ŸããŠåŸè ãå°ãªããšãçã¢ã«éçšåºŠã奜
ãŸããã¯ãïŒãïŒåã¢ã«éãçšããããã®åå¿æž©
床ããã³åå¿æéããšãã«éå®ãããªãããéåžž
宀枩ã100âçšåºŠã奜ãŸããã¯50ã80âã«ãŠã30
åéãïŒæéçšåºŠã§è¡ãªãããã ãŸãã«ã«ãã³é žïŒãããªããšãã«ãã¹ãã€ã³ã
ãžãšãã«ã¯ãããã¹ããšãŒããªã©ã®ãªã³ååç©ã§
掻æ§åããããã«ååç©1aïŒ1cãŸãã¯1lãåå¿ã
ããæ¹æ³ã¯ãé©åœãªæº¶åªäžã§è¡ãªãããã溶åªãš
ããŠã¯åå¿ã«åœ±é¿ãäžããªããã®ãªãã°äœãã䜿
çšããããšãã§ããå ·äœçã«ã¯å¡©åã¡ãã¬ã³ãã¯
ãããã«ã ããžã¯ãã«ãšã¿ã³ãªã©ã®ããã²ã³åç
çŽ é¡ããã³ãŒã³ããã«ãšã³ããã·ã¬ã³ãªã©ã®è³éŠ
æçåæ°ŽçŽ é¡ããžãšãã«ãšãŒãã«ãããã©ããã
ãã©ã³ããžã¡ããã·ãšã¿ã³ãªã©ã®ãšãŒãã«é¡ãé ¢
é žã¡ãã«ãé ¢é žãšãã«ãªã©ã®ãšã¹ãã«é¡ããžã¡ã
ã«ãã«ã ã¢ããããžã¡ãã«ã¹ã«ããã·ãããããµ
ã¡ãã«ãªã³é žããªã¢ãããªã©ã®éãããã³æ§æ¥µæ§
溶åªãªã©ãæããããã該åå¿ã§ã¯ååç©1aïŒ
1cãŸãã¯1lèªäœãå¡©åºæ§ååç©ãšããŠåãããã
ãããçè«éããéå°ã«çšããããšã«ãã€ãŠåå¿
ã¯è¯å¥œã«é²è¡ããããå¿ èŠã«å¿ããŠãä»ã®å¡©åºæ§
ååç©ãäŸãã°ãããªãšãã«ã¢ãã³ãããªã¡ãã«
ã¢ãã³ãããªãžã³ããžã¡ãã«ã¢ããªã³ãâã¡ã
ã«ã¢ã«ããªã³ãïŒâãžã¡ãã«ã¢ããããªãžã³ã
ïŒïŒïŒâãžã¢ã¶ãã·ã¯ãã4.3.0ãããã³âïŒ
ïŒDBNïŒãïŒïŒïŒâãžã¢ã¶ãã·ã¯ãã5.4.0ããŠã³
ãã»ã³âïŒïŒDBUïŒãïŒïŒïŒâãžã¢ã¶ãã·ã¯ã
ã2.2.2ããªã¯ã¿ã³ïŒDABCOïŒãªã©ã®ææ©å¡©åºã
çé žã«ãªãŠã ãçé žãããªãŠã ãçé žæ°ŽçŽ ã«ãªãŠ
ã ãçé žæ°ŽçŽ ãããªãŠã ãªã©ã®ç¡æ©å¡©åºãçšãã
ããšãã§ããã該åå¿ã¯çŽïŒã150âã奜ãŸãã
ã¯çŽïŒã100âã§ãçŽïŒã30æéè¡ãªãããšã«ã
ãéæããããååç©1aïŒ1cãŸãã¯1lã«å¯Ÿãããª
ã³ååç©ããã³ã«ã«ãã³é žïŒã®äœ¿çšå²åã¯ããã
ãããéåžžå°ãªããšãçã¢ã«éçšåºŠã奜ãŸããã¯
ïŒãïŒåã¢ã«éã§ããã åèšåå¿åŒâã«ãããŠãååç©1aãŸãã¯1b
ãåŒ(4)ã®ã¢ã«ã³ãŒã«ãçšããŠãšã¹ãã«åããããš
ã«ãããããã察å¿ããç®çååç©1cãŸãã¯1d
ã«å°ãããšãã§ããã ãã®ãšã¹ãã«ååå¿ã¯éåžžã®ãšã¹ãã«ååå¿ã®
åå¿æ¡ä»¶ãããããæ¡çšãããäŸãã°(1)溶åªäžè±
æ°Žå€ã®ååšäžã«è±æ°Žçž®åããããã(2)é žæ§ãŸãã¯
å¡©åºæ§è§Šåªã®ååšäžã«é©åœãªæº¶åªäžã§åå¿ãã
ãã(1)ã®æ¹æ³ã§äœ¿çšããã溶åªãšããŠã¯ãäŸãã°
å¡©åã¡ãã¬ã³ãã¯ãããã«ã ããžã¯ãã«ãšã¿ã³ãª
ã©ã®ããã²ã³åççŽ é¡ããã³ãŒã³ããã«ãšã³ãã
ã·ã¬ã³ãªã©ã®è³éŠæçåæ°ŽçŽ é¡ããžãšãã«ãšãŒã
ã«ãããã©ããããã©ã³ããžã¡ããã·ãšã¿ã³ãªã©
ã®ãšãŒãã«é¡ããžã¡ãã«ãã«ã ã¢ããããžã¡ãã«
ã¹ã«ããã·ãããããµã¡ãã«ãªã³é žããªã¢ãããª
ã©ã®éãããã³æ§æ¥µæ§æº¶åªãªã©ãæããããããŸ
ãè±æ°Žå€ãšããŠã¯ãäŸãã°ãžã·ã¯ãããã·ã«ã«ã«
ããžã€ãããã«ã«ããã«ãžã€ãããŸãŒã«ãªã©ãäŸ
瀺ã§ãããååç©1aãŸãã¯1bã«å¯Ÿããã¢ã«ã³ãŒ
ã«ïŒã®äœ¿çšå²åã¯å°ãªããšãçã¢ã«ã奜ãŸããã¯
çã¢ã«ã1.5åã¢ã«ã§ãããè±æ°Žå€ã®äœ¿çšå²åã¯
ååç©1aãŸãã¯1bã«å¯ŸããŠå°ãªããšãçã¢ã«ã
奜ãŸããã¯çã¢ã«ã1.5åã¢ã«ã§ãããåå¿æž©åºŠ
ã¯é垞宀枩ã150âã奜ãŸããã¯50ã100âã§ã該
åå¿ã¯äžè¬ã«ïŒã10æéã§çµäºããã (2)ã®æ¹æ³ã§çšããããé žæ§è§ŠåªãšããŠã¯ãäŸã
ã°å¡©é žã¬ã¹ãæ¿ç¡«é žããªã³é žãããªãªã³é žãäžã
ãåããŠçŽ ãéå¡©çŽ é žãªã©ã®ç¡æ©é žãããªããã
é ¢é žãããªãããã¡ã¿ã³ã¹ã«ãã³é žãããã¿ã¬ã³
ã¹ã«ãã³é žãïœâãã·ã«é žããã³ãŒã³ã¹ã«ãã³
é žããšã¿ã³ã¹ã«ãã³é žãªã©ã®ææ©é žãããªã¯ãã
ã¡ã¿ã³ã¹ã«ãã³é žç¡æ°Žç©ãããªãããã¡ã¿ã³ã¹ã«
ãã³é žç¡æ°Žç©ãªã©ã®é žç¡æ°Žç©ãå¡©åããªãã«ãã¢
ã»ãã³ãžã¡ãã«ã¢ã»ã¿ãŒã«ãªã©ãäŸç€ºã§ãããã
ãã«é žæ§ã€ãªã³äº€ææš¹èãæ¬çºæã®è§ŠåªãšããŠçš
ããããšãã§ãããå¡©åºæ§è§ŠåªãšããŠã¯å ¬ç¥ã®ã
ã®ãåºã䜿çšã§ããäŸãã°ãæ°Žé žåãããªãŠã ã
æ°Žé žåã«ãªãŠã ãçé žãããªãŠã ãçé žã«ãªãŠ
ã ãçé žæ°ŽçŽ ãããªãŠã ãçé žæ°ŽçŽ ã«ãªãŠã ãç
é žéãªã©ã®ç¡æ©å¡©åºããããªãŠã ã¡ãã©ãŒããã
ããªãŠã ãšãã©ãŒããªã©ã®ã¢ã«ã³ã©ãŒããæãã
ãããæ¬åå¿ã¯ç¡æº¶åªãããã¯æº¶åªäžã®ãããã§
ãé²è¡ãããçšãããã溶åªãšããŠã¯ãéåžžã®ãš
ã¹ãã«ååå¿ã«äœ¿çšããã溶åªãæå¹ã«äœ¿çšã§
ããå ·äœçã«ã¯ãã³ãŒã³ããã«ãšã³ããã·ã¬ã³ãª
ã©ã®è³éŠæçåæ°ŽçŽ é¡ããžã¯ããã¡ã¿ã³ããžã¯ã
ããšã¿ã³ãã¯ãããã«ã ãåå¡©åççŽ ãªã©ã®ãã
ã²ã³åçåæ°ŽçŽ é¡ããžãšãã«ãšãŒãã«ãããã©ã
ãããã©ã³ããžãªããµã³ããšãã¬ã³ã°ãªã³ãŒã«ã¢
ãã¡ãã«ãšãŒãã«ãªã©ã®ãšãŒãã«é¡ãæããã
ããããã«äžèšåå¿ã¯ç¡æ°Žå¡©åã«ã«ã·ãŠã ãç¡æ°Ž
ç¡«é žé ãç¡æ°Žç¡«é žã«ã«ã·ãŠã ãäºé žåãªã³ãªã©ã®
也ç¥å€ã®äœ¿çšã«ããæå©ã«è¡ãªãããã該åå¿ã«
ãããååç©1aãŸãã¯1bãšã¢ã«ã³ãŒã«ïŒãšã®äœ¿
çšå²åã¯ç¹ã«éå®ãããåºãç¯å²ããé©å®éžæã§
ããããç¡æº¶åªã®å Žåã¯åè ã«å¯ŸããŠåŸè ã倧é
å°ã«çšãã溶åªãçšããå Žåã«ã¯åè ã«å¯ŸããŠåŸ
è ãçã¢ã«ãïŒåã¢ã«ã奜ãŸããã¯çã¢ã«ãïŒå
ã¢ã«çšãããåå¿æž©åºŠã¯ç¹ã«éå®ãããªãããé
åžžâ20ã200âçšåºŠã奜ãŸããã¯ïŒã150âçšåºŠã§
ãããåå¿æéã¯éåžžïŒã20æéçšåºŠã§ããã ãªããåèšåå¿åŒâã«ãããŠãåŒïŒ1bïŒïŒ
ïŒ1cïŒïŒïŒ1dïŒïŒïŒ1nïŒïŒïŒ1lïŒãŸãã¯ïŒ1mïŒã®ååç©
ãå æ°Žå解ããŠåŒïŒ1aïŒã®ååç©ã«å°ãããšã
ã§ãããã®å æ°Žå解ã¯ååç©ïŒã®å æ°Žå解ã®å Žå
ãšåæ§ã®æ¡ä»¶ãæ¡çšããããã ååç©1aãŸãã¯1bã®ã¢ããååå¿ã¯ãåèšå
åç©1aïŒ1cãŸãã¯1lã®ã¢ããçµåçæåå¿ãšåæ§
ã®æ¡ä»¶ã§è¡ãªãããšãã§ããã ååç©1aïŒ1cãŸãã¯1lãšååç©ïŒãšã®åå¿ã¯ç¡
溶åªãŸãã¯éåžžã®äžæŽ»æ§æº¶åªäžã§ã宀枩ã200â
çšåºŠã奜ãŸããã¯å®€æž©ã120âã®æž©åºŠæ¡ä»¶äžãæ°
æéã24æéçšåºŠè¡ãªããããäžæŽ»æ§æº¶åªãšããŠ
ã¯ãäŸãã°ãžãªããµã³ãããã©ããããã©ã³ããš
ãã¬ã³ã°ãªã³ãŒã«ãžã¡ãã«ãšãŒãã«ããžãšãã«ãš
ãŒãã«ãªã©ã®ãšãŒãã«é¡ããã³ãŒã³ããã«ãšã³ã
ãã·ã¬ã³ãªã©ã®è³éŠæçåæ°ŽçŽ é¡ãã¡ã¿ããŒã«ã
ãšã¿ããŒã«ãã€ãœãããããŒã«ãªã©ã®äœçŽã¢ã«ã³
ãŒã«é¡ããžã¡ãã«ãã«ã ã¢ããããžã¡ãã«ã¹ã«ã
ãã·ãããããµã¡ãã«ãªã³é žããªã¢ãããã¢ã»ã
ã³ãã¢ã»ããããªã«ãªã©ã®æ¥µæ§æº¶åªãçšããã
ããäžèšåå¿ã¯ãããæå©ã«ã¯ãå¡©åºæ§ååç©ã
è±é žå€ãšããŠçšããŠè¡ãªãããã該塩åºæ§ååç©
ãšããŠã¯ãäŸãã°çé žã«ãªãŠã ãçé žãããªãŠ
ã ãæ°Žé žåãããªãŠã ãçé žæ°ŽçŽ ãããªãŠã ãã
ããªãŠã ã¢ãããæ°ŽçŽ åãããªãŠã ãªã©ã®ã¢ã«ã«
ãªéå±ååç©ãããªãšãã«ã¢ãã³ãããªãããã«
ã¢ãã³ãããªãžã³ããããªã³ãªã©ã®ç¬¬äžçŽã¢ãã³
é¡ãäŸç€ºãããããŸãäžèšåå¿ã¯ãå¿ èŠã«å¿ããŠ
åå¿ä¿é²å€ãšããŠããšãŠåã«ãªãŠã ããšãŠåãã
ãªãŠã ãªã©ã®ãšãŠåã¢ã«ã«ãªéå±ååç©ãŸãã¯ã
ããµã¡ãã«ãªã³é žããªã¢ãããæ·»å ããŠè¡ãªãåŸ
ããäžèšåå¿ã«ãããååç©1aïŒ1cãŸãã¯1lãšå
åç©ïŒãšã®äœ¿çšå²åã¯ãšãã«éå®ãããªãããé
åžžãåè ã«å¯ŸããŠåŸè ãçã¢ã«ãéå°éã奜ãŸã
ãã¯çã¢ã«ãïŒåã¢ã«ã§ããã äžèšååç©1aïŒ1cãŸãã¯1lãšååç©ïŒãšã®åå¿
ã§åŸãããååç©ïŒïœïŒïŒïœãŸãã¯ïŒïœãåæ§ã®
æ¡ä»¶äžã«ããã«ã¹ã«ããã«åããŠäžè¬åŒ K0012 ãåŒäžãR1ïŒR2ïŒR3ïŒR4â²ïŒïŒ¡ããã³ïœã¯åèš
ãšåããR5â²ã¯çœ®æåºãšããŠäœçŽã¢ã«ãã«åºãŸã
ã¯ããã²ã³ååãæããããšã®ããããšãã«ã¹ã«
ããã«åºã瀺ãã ã§ç€ºãããååç©ã«å°ãããšãã§ããã ãŸãåŒ(1)ã®ååç©äžãR4ã眮æåºãšããŠäœçŽ
ã¢ã«ãã«ãŸãã¯ããã²ã³ååãæããããšã®ãã
ããšãã«ã¹ã«ããã«åºã§ããå Žåã¯ãååç©1a
ãšååç©ïŒãšã®åå¿ãšåæ§ã®æ¡ä»¶äžã«ã¢ã·ã«åã
ãŠäžè¬åŒ K0013 ãåŒäžãR1ïŒR2ïŒR3ïŒR5â²ïŒR6ïŒïŒ¡ããã³ïœã¯
åèšãšåãã ã§ç€ºãããååç©ã«å°ãããšãã§ããã ããã«ãåèšååç©ïŒïœã¯ãç¡«é žãå¡©é žãèå
æ°ŽçŽ é žãªã©ã®é±é žã®ååšäžã«ãæ°Žãã¡ã¿ããŒã«ã
ãšã¿ããŒã«ãã€ãœãããããŒã«ãªã©ã®äœçŽã¢ã«ã³
ãŒã«é¡ããŸãã¯æ°ŽãšäœçŽã¢ã«ã³ãŒã«é¡ãšã®æ··å溶
åªäžãéåžžã宀枩ã150âã奜ãŸããã¯60ã120â
ã«ãŠ30åã150æéçšåºŠåå¿ãããããšã«ããäž
è¬åŒïŒ1oïŒã®ååç©ã«å°ãããšãã§ããã æ¬çºæã®ååç©ã¯ãäžèšåå¿åŒâã«ç€ºãæ¹æ³
ã«ãã€ãŠã補é ã§ããã
ãè¡šã
ãåŒäžãR1ïŒR2ïŒR3â²ïŒR3â³ïŒR4â²ïŒR6ïŒïŒžïŒ
ïŒïœããã³ã«ã«ãã¹ããªã«éªšæ žã®ïŒäœãšïŒäœé
ã®çµåã¯åèšã«åãã ããªãã¡ãåŒ(6)ã®ååç©ãšåŒ(7)ã®ååç©ãåå¿
ãããçããäžéäœãå æ°Žå解ããææã«ããã
ã®çæç©ãå æ°Žå解ãã¢ã·ã«åããšã¹ãã«åããŸ
ãã¯ãããã®çµåãã«ããç®çã®ã«ã«ãã¹ããªã«
èªå°äœã«å°ãã 該ååç©ïŒãšååç©ïŒãšã®åå¿ã¯å¡©åºæ§ååç©
ã®ååšäžãé©åœãªæº¶åªäžã§è¡ãªãããšãã§ããã
çšããããå¡©åºæ§ååç©ãšããŠã¯ãäŸãã°ããªãš
ãã«ã¢ãã³ãããªã¡ãã«ã¢ãã³ãããªãžã³ããã
ãªãžã³ãâã¡ãã«ã¢ã«ããªã³ãïŒâãžã¡ãã«ã¢
ããããªãžã³ãªã©ã®ææ©å¡©åºãæ°Žé žåã«ãªãŠã ã
æ°Žé žåãããªãŠã ãæ°ŽçŽ åãããªãŠã ããããªãŠ
ã ã¢ãããçé žãããªãŠã ãçé žã«ãªãŠã ãçé ž
æ°Žé žãããªãŠã ãçé žæ°ŽçŽ ã«ãªãŠã ãªã©ã®ç¡æ©å¡©
åºãé ¢é žãããªãŠã ãé ¢é žã«ãªãŠã ãããããªã³
é žãããªãŠã ãªã©ã®èèªæã«ã«ãã³é žã®ã¢ã«ã«ãª
éå±å¡©ããããªãŠã ã¡ãã©ãŒãããããªãŠã ãšã
ã©ãŒããªã©ã®äœçŽã¢ã«ã³ãŒã«ã®ã¢ã«ã«ãªéå±å¡©ãª
ã©ãæããããã ãŸã溶åªãšããŠã¯ãäŸãã°ã¡ã¿ããŒã«ããšã¿ã
ãŒã«ãã€ãœãããããŒã«ãªã©ã®ã¢ã«ã³ãŒã«é¡ãã
ããµã³ãã·ã¯ããããµã³ãªã©ã®çåæ°ŽçŽ é¡ããžãš
ãã¬ã³ã°ãªã³ãŒã«ãžã¡ãã«ãšãŒãã«ããžãªããµ
ã³ãããã©ããããã©ã³ããžãšãã«ãšãŒãã«ãªã©
ã®ãšãŒãã«é¡ãé ¢é žãšãã«ãé ¢é žã¡ãã«ãªã©ã®ãš
ã¹ãã«é¡ããã³ãŒã³ããã«ãšã³ããã·ã¬ã³ãªã©ã®
è³éŠæçåæ°ŽçŽ é¡ãããã«ãæ°Žãé ¢é žãç¡æ°Žé ¢
é žãããªãžã³ãªã©ãæããããã ååç©ïŒã«å¯Ÿããååç©ïŒã®äœ¿çšå²åã¯åè ã«
察ããŠåŸè ãå°ãªããšãçã¢ã«ã奜ãŸããã¯çã¢
ã«ãïŒåã¢ã«ã§ããã該åå¿ã¯ãéåžž50ã200âã
奜ãŸããã¯80ã150âã«ãŠãçŽ30åãïŒæéçšåºŠ
ã§çµäºããã äžèšååç©ïŒãšååç©ïŒãšã®åå¿ã«ãããåŒ K0015 ãåŒäžãR1ïŒR2.R6ïŒïŒ¡ïŒïœããã³ã«ã«ãã¹ã
ãªã«éªšæ žã®ïŒäœãšïŒäœéã®çµåã¯åèšã«åãã ã§ç€ºãããäžéäœãçãããããã®ãã®ã¯ãäŸã
ã°æ°Žâã¢ã»ãã³äžã§å ç±éæµããããšã«ãã容æ
ã«å æ°Žå解ãããŠåŒïŒ1bâ²ïŒã®ååç©ãåŸãããã ãã®ååç©1bâ²ã¯ãåèšåå¿åŒâã«ãããå
åç©ïŒã®å æ°Žå解ãšåæ§ã®æ¡ä»¶äžã«å æ°Žå解ãã
ããšã«ãã容æã«ä»ã®ç®çååç©1aâ²ã«å°ãããã ããã«ãååç©1bâ²ãŸãã¯1aâ²ããåèšåå¿åŒâ
ã«ããããšã¹ãã«ååå¿ãšåæ§ã«ããŠåŒ(4)ã®å
åç©ãçšããŠãšã¹ãã«åããããšã«ãããããã
ãååç©1dâ²ãŸãã¯1câ²ã«å°ãããšãã§ããããŸ
ããååç©1aâ²ïŒ1câ²ãŸãã¯1lâ²ããåèšåå¿åŒâ
ã«ãããã¢ã·ã«ååå¿ãšåæ§ã«ããŠåŒ(3)ã®ååç©
ãçšããŠã¢ã·ã«åããããšã«ãããããããåå
ç©1bâ²ïŒ1dâ²ãŸãã¯1mâ²ã«å°ãããšãã§ããã ãŸãååç©1aâ²ãŸãã¯1bâ²ãåèšåå¿åŒâã«ã
ããã¢ããååå¿ãšåæ§ã«ããŠã¢ããåããããš
ã«ããããããååç©1lâ²ãŸãã¯ïŒnâ²ã«å°ãããšã
ã§ããã ååç©1aâ²ïŒ1câ²ãŸãã¯1lâ²ãšååç©ïŒãšã®åå¿
ã¯ãåèšåå¿åŒâã«ãããååç©1aïŒ1cãŸã
ã¯1lãšååç©ïŒãšã®åå¿ãšåæ§ã®æ¡ä»¶äžã«è¡ãªã
ããšãã§ããã ããã«ååç©1câ²ïŒ1dâ²ïŒ1lâ²ïŒ1mâ²ãŸãã¯1nâ²ãå
å¿åŒâã«ãããååç©ïŒã®å æ°Žå解åå¿ãšåæ§
ã®æ¡ä»¶äžã«å æ°Žå解ããŠååç©1aâ²ã«å°ãããšã
ã§ããã åèšååç©1aâ²ïŒ1câ²ãŸãã¯1lâ²ãšååç©ïŒãšã®å
å¿ã§åŸãããååç©1oâ²ïŒ1pâ²ãŸãã¯ïŒqâ²ãåæ§ã®
æ¡ä»¶äžã«ããã«ã¹ã«ããã«åããŠäžè¬åŒ K0016 ãåŒäžãR1ïŒR2ïŒR3ïŒR4â²ïŒR5â²ããã³ïœã¯å
èšã«åãã ã§ç€ºãããååç©ã«å°ãããšãã§ããã ãŸãäžè¬åŒ(1)ã®ååç©ã§R4ã眮æåºãšããŠäœ
çŽã¢ã«ãã«åºãŸãã¯ããã²ã³ååãæããããšã®
ããããšãã«ã¹ã«ããã«åºã§ãâCHãCHâã®çµ
åãïŒéçµåã§ããå Žåã¯ãååç©1aãšååç©
ïŒãšã®åå¿ãšåæ§ã®æ¡ä»¶ã§ã¢ã·ã«åããŠãäžè¬åŒ K0017 ãåŒäžãR1ïŒR2ïŒR3ïŒR5â²ïŒR6ïŒïŒ¡ããã³ïœã¯
åèšã«åãã ã§ç€ºãããååç©ã«å°ãããã åèšååç©1râ²ã¯ãåèš1rã®å Žåãšåæ§ã®æ¡ä»¶
äžã«åŠçããŠååç©1oâ²ã«å°ãããšãã§ããã æ¬çºæååç©ã®ãã¡ã眮æåº
ïŒïœããã³ã«ã«ãã¹ããªã«éªšæ žã®ïŒäœãšïŒäœé
ã®çµåã¯åèšã«åãã ããªãã¡ãåŒ(6)ã®ååç©ãšåŒ(7)ã®ååç©ãåå¿
ãããçããäžéäœãå æ°Žå解ããææã«ããã
ã®çæç©ãå æ°Žå解ãã¢ã·ã«åããšã¹ãã«åããŸ
ãã¯ãããã®çµåãã«ããç®çã®ã«ã«ãã¹ããªã«
èªå°äœã«å°ãã 該ååç©ïŒãšååç©ïŒãšã®åå¿ã¯å¡©åºæ§ååç©
ã®ååšäžãé©åœãªæº¶åªäžã§è¡ãªãããšãã§ããã
çšããããå¡©åºæ§ååç©ãšããŠã¯ãäŸãã°ããªãš
ãã«ã¢ãã³ãããªã¡ãã«ã¢ãã³ãããªãžã³ããã
ãªãžã³ãâã¡ãã«ã¢ã«ããªã³ãïŒâãžã¡ãã«ã¢
ããããªãžã³ãªã©ã®ææ©å¡©åºãæ°Žé žåã«ãªãŠã ã
æ°Žé žåãããªãŠã ãæ°ŽçŽ åãããªãŠã ããããªãŠ
ã ã¢ãããçé žãããªãŠã ãçé žã«ãªãŠã ãçé ž
æ°Žé žãããªãŠã ãçé žæ°ŽçŽ ã«ãªãŠã ãªã©ã®ç¡æ©å¡©
åºãé ¢é žãããªãŠã ãé ¢é žã«ãªãŠã ãããããªã³
é žãããªãŠã ãªã©ã®èèªæã«ã«ãã³é žã®ã¢ã«ã«ãª
éå±å¡©ããããªãŠã ã¡ãã©ãŒãããããªãŠã ãšã
ã©ãŒããªã©ã®äœçŽã¢ã«ã³ãŒã«ã®ã¢ã«ã«ãªéå±å¡©ãª
ã©ãæããããã ãŸã溶åªãšããŠã¯ãäŸãã°ã¡ã¿ããŒã«ããšã¿ã
ãŒã«ãã€ãœãããããŒã«ãªã©ã®ã¢ã«ã³ãŒã«é¡ãã
ããµã³ãã·ã¯ããããµã³ãªã©ã®çåæ°ŽçŽ é¡ããžãš
ãã¬ã³ã°ãªã³ãŒã«ãžã¡ãã«ãšãŒãã«ããžãªããµ
ã³ãããã©ããããã©ã³ããžãšãã«ãšãŒãã«ãªã©
ã®ãšãŒãã«é¡ãé ¢é žãšãã«ãé ¢é žã¡ãã«ãªã©ã®ãš
ã¹ãã«é¡ããã³ãŒã³ããã«ãšã³ããã·ã¬ã³ãªã©ã®
è³éŠæçåæ°ŽçŽ é¡ãããã«ãæ°Žãé ¢é žãç¡æ°Žé ¢
é žãããªãžã³ãªã©ãæããããã ååç©ïŒã«å¯Ÿããååç©ïŒã®äœ¿çšå²åã¯åè ã«
察ããŠåŸè ãå°ãªããšãçã¢ã«ã奜ãŸããã¯çã¢
ã«ãïŒåã¢ã«ã§ããã該åå¿ã¯ãéåžž50ã200âã
奜ãŸããã¯80ã150âã«ãŠãçŽ30åãïŒæéçšåºŠ
ã§çµäºããã äžèšååç©ïŒãšååç©ïŒãšã®åå¿ã«ãããåŒ K0015 ãåŒäžãR1ïŒR2.R6ïŒïŒ¡ïŒïœããã³ã«ã«ãã¹ã
ãªã«éªšæ žã®ïŒäœãšïŒäœéã®çµåã¯åèšã«åãã ã§ç€ºãããäžéäœãçãããããã®ãã®ã¯ãäŸã
ã°æ°Žâã¢ã»ãã³äžã§å ç±éæµããããšã«ãã容æ
ã«å æ°Žå解ãããŠåŒïŒ1bâ²ïŒã®ååç©ãåŸãããã ãã®ååç©1bâ²ã¯ãåèšåå¿åŒâã«ãããå
åç©ïŒã®å æ°Žå解ãšåæ§ã®æ¡ä»¶äžã«å æ°Žå解ãã
ããšã«ãã容æã«ä»ã®ç®çååç©1aâ²ã«å°ãããã ããã«ãååç©1bâ²ãŸãã¯1aâ²ããåèšåå¿åŒâ
ã«ããããšã¹ãã«ååå¿ãšåæ§ã«ããŠåŒ(4)ã®å
åç©ãçšããŠãšã¹ãã«åããããšã«ãããããã
ãååç©1dâ²ãŸãã¯1câ²ã«å°ãããšãã§ããããŸ
ããååç©1aâ²ïŒ1câ²ãŸãã¯1lâ²ããåèšåå¿åŒâ
ã«ãããã¢ã·ã«ååå¿ãšåæ§ã«ããŠåŒ(3)ã®ååç©
ãçšããŠã¢ã·ã«åããããšã«ãããããããåå
ç©1bâ²ïŒ1dâ²ãŸãã¯1mâ²ã«å°ãããšãã§ããã ãŸãååç©1aâ²ãŸãã¯1bâ²ãåèšåå¿åŒâã«ã
ããã¢ããååå¿ãšåæ§ã«ããŠã¢ããåããããš
ã«ããããããååç©1lâ²ãŸãã¯ïŒnâ²ã«å°ãããšã
ã§ããã ååç©1aâ²ïŒ1câ²ãŸãã¯1lâ²ãšååç©ïŒãšã®åå¿
ã¯ãåèšåå¿åŒâã«ãããååç©1aïŒ1cãŸã
ã¯1lãšååç©ïŒãšã®åå¿ãšåæ§ã®æ¡ä»¶äžã«è¡ãªã
ããšãã§ããã ããã«ååç©1câ²ïŒ1dâ²ïŒ1lâ²ïŒ1mâ²ãŸãã¯1nâ²ãå
å¿åŒâã«ãããååç©ïŒã®å æ°Žå解åå¿ãšåæ§
ã®æ¡ä»¶äžã«å æ°Žå解ããŠååç©1aâ²ã«å°ãããšã
ã§ããã åèšååç©1aâ²ïŒ1câ²ãŸãã¯1lâ²ãšååç©ïŒãšã®å
å¿ã§åŸãããååç©1oâ²ïŒ1pâ²ãŸãã¯ïŒqâ²ãåæ§ã®
æ¡ä»¶äžã«ããã«ã¹ã«ããã«åããŠäžè¬åŒ K0016 ãåŒäžãR1ïŒR2ïŒR3ïŒR4â²ïŒR5â²ããã³ïœã¯å
èšã«åãã ã§ç€ºãããååç©ã«å°ãããšãã§ããã ãŸãäžè¬åŒ(1)ã®ååç©ã§R4ã眮æåºãšããŠäœ
çŽã¢ã«ãã«åºãŸãã¯ããã²ã³ååãæããããšã®
ããããšãã«ã¹ã«ããã«åºã§ãâCHãCHâã®çµ
åãïŒéçµåã§ããå Žåã¯ãååç©1aãšååç©
ïŒãšã®åå¿ãšåæ§ã®æ¡ä»¶ã§ã¢ã·ã«åããŠãäžè¬åŒ K0017 ãåŒäžãR1ïŒR2ïŒR3ïŒR5â²ïŒR6ïŒïŒ¡ããã³ïœã¯
åèšã«åãã ã§ç€ºãããååç©ã«å°ãããã åèšååç©1râ²ã¯ãåèš1rã®å Žåãšåæ§ã®æ¡ä»¶
äžã«åŠçããŠååç©1oâ²ã«å°ãããšãã§ããã æ¬çºæååç©ã®ãã¡ã眮æåº
ãåŒãäžã®ççŽ éçµåãäžé
çµåã®ååç©ã¯ãäžèšåå¿åŒâã«ç€ºããããã
ã«ã察å¿ããäºéçµåãæããååç©ãéå ãã
ããšã«ãã補é ã§ããã K0019 ãåŒäžãR1ïŒR2ïŒR3ïŒR4ïŒR5ïŒïŒ¡ïŒïœããã³
ã«ã«ãã¹ããªã«éªšæ žã®ïŒäœãšïŒäœéã®çµåã¯åèš
ã«åãã äžèšã®éå åå¿ã¯ãéåžžãé©åœãªéå 觊åªã®å
åšäžã«æ¥è§Šéå ããããšã«ããè¡ãªããããçšã
ãããéå 觊åªãšããŠã¯ãäŸãã°çœéãé žåçœ
éããã©ãžãŠã é»ããã©ãžãŠã ççŽ ãã©ããŒãã
ã±ã«ãªã©ã®éåžžã®æ¥è§Šéå çšè§Šåªãå«ãŸãããã®
䜿çšéã¯ååç©ïŒâ²ã«å¯ŸããéåžžçŽ0.2ã0.5åé
éã®ç¯å²ã§ããããã®æ¥è§Šéå ã¯ãäŸãã°æ°Žãã¡
ã¿ããŒã«ããšã¿ããŒã«ãã€ãœãããããŒã«ããã
ã©ããããã©ã³ããšãã«ãšãŒãã«ãªã©ã®æº¶åªäžã
ïŒã10æ°å§ã奜ãŸããã¯ïŒãïŒæ°å§ã®æ°ŽçŽ é°å²æ°
äžãâ30âã溶åªã®æ²žç¹æž©åºŠã奜ãŸããã¯ïŒâã
宀枩ä»è¿ã«ãŠãããæ¯ãæ··ããããšã«ããè¡ãªã
ããã ããã«ãæ¬çºæã®ååç©ãäžèšåå¿åŒâã
ã«ç€ºãæ¹æ³ã«ããä»ã®æ¬çºæååç©ã«å°ãããšã
ã§ããã K0020 ãåŒäžãR1ïŒR3ïŒR4ïŒR5ïŒïŒ¡ïŒïœããã³ã«ã«
ãã¹ããªã«éªšæ žã®ïŒäœãšïŒäœéã®çµåã¯åèšã«å
ããR2â²ã¯äœçŽã¢ã«ã³ãã·ã瀺ãã äžèšåå¿åŒâã«ç€ºãååç©1eãååç©1fã«å°
ãåå¿ã¯ãååç©1eãèåæ°ŽçŽ é žæ°Žæº¶æ¶²äžã§50ã
150âã«ãŠïŒã10æéçšåºŠå ç±åŠçããããšã«ã
ãè¡ãªãããã K0021 ãåŒäžãR2ïŒR3ïŒR4ïŒR5ïŒïŒ¡ïŒïœããã³ã«ã«
ãã¹ããªã«éªšæ žã®ïŒäœãšïŒäœéã®çµåã¯åèšã«å
ããR1â²ã¯äœçŽã¢ã«ãã«ãäœçŽã¢ã«ã±ãã«ãäœçŽ
ã¢ã«ããã«ãŸãã¯ããšãã«äœçŽã¢ã«ãã«ã瀺ãã äžèšååç©1gã®ã¢ã«ãã«ååå¿ã¯ãäŸãã°æ°Ž
çŽ åãããªãŠã ãæ°ŽçŽ åã«ãªãŠã ãéå±ã«ãªãŠ
ã ãéå±ãããªãŠã ããããªãŠã ã¢ãããã«ãªãŠ
ã ã¢ãããæ°Žé žåãããªãŠã ãæ°Žé žåã«ãªãŠã ã
çé žãããªãŠã ãçé žã«ãªãŠã ãçé žæ°ŽçŽ ãããª
ãŠã ãçé žæ°ŽçŽ ã«ãªãŠã ãªã©ã®å¡©åºæ§ååç©ã®å
åšäžãé©åœãªæº¶åªäžã«ãŠè¡ãªããããçšãããã
溶åªãšããŠã¯ãäŸãã°ãžãªããµã³ãããã©ããã
ãã©ã³ããžãšãã«ãšãŒãã«ããžãšãã¬ã³ã°ãªã³ãŒ
ã«ãžã¡ãã«ãšãŒãã«ãããã©ããããã©ã³ãªã©ã®
ãšãŒãã«é¡ããã³ãŒã³ããã«ãšã³ããã·ã¬ã³ãã¯
ãããã³ãŒã³ãªã©ã®è³éŠæçåæ°ŽçŽ é¡ããžã¡ãã«
ãã«ã ã¢ããããžã¡ãã«ã¹ã«ããã·ãããããµã¡
ãã«ãªã³é žããªã¢ãããã¢ã³ã¢ãã¢æ°Žãªã©ãŸãã¯
ãããã®æ··å溶åªãæãããããã¢ã«ãã«åå€ãš
ããŠã¯ãäžè¬åŒR1â²XïŒR1â²ã¯åèšã«åããã¯ã
ãã²ã³ååïŒã®ããã²ã³åã¢ã«ãã«ããžã¡ãã«ç¡«
é žããžãšãã«ç¡«é žãªã©ã®ãžã¢ã«ãã«ç¡«é žããã³ãž
ã«ïœâãã«ãšã³ã¹ã«ãããŒããã¡ãã«ïœâãã«ãš
ã³ã¹ã«ãããŒããªã©ã®ãã«ãšã³ã¹ã«ãããŒãé¡ãª
ã©ãæãããããã®äœ¿çšå²åã¯ç¹ã«éå®ãããªã
ããéåžžååç©1gã«å¯Ÿãå°ãªããšãçã¢ã«ã奜
ãŸããã¯çã¢ã«ãïŒåã¢ã«ã§ããã該åå¿ã¯éåžž
ïŒã70âçšåºŠã奜ãŸããã¯ïŒâã宀枩ä»è¿ã§è¡ãª
ãããäžè¬ã«30åã12æéçšåºŠã§çµäºããã K0022 ãåŒäžãR1ïŒR2ïŒR3ïŒR4ïŒR5ïŒïŒ¡ããã³ïœã¯
åèšã«åãã äžèšã®ååç©1iãè±æ°ŽçŽ ããŠååç©1kã«å°ãå
å¿ã¯ãé©åœãªæº¶åªäžã§è±æ°ŽçŽ å€ã§åŠçããŠè¡ãªã
ãããè±æ°ŽçŽ å€ãšããŠã¯ãäŸãã°ïŒïŒïŒâãžã¯ã
ãâïŒïŒïŒâãžã·ã¢ããã³ãŸããã³ãïŒïŒïŒïŒ
ïŒïŒïŒâããã©ã¯ãããã³ãŸããã³ïŒäžè¬åã¯ã
ã©ãã«ïŒãªã©ã®ãã³ãŸããã³é¡ãâããã¢ã³ã
ã¯é žã€ãããâã¯ããã³ãã¯é žã€ãããèçŽ ãª
ã©ã®ããã²ã³åå€ãäºé žåã»ã¬ã³ããã©ãžãŠã ç
çŽ ããã©ãžãŠã é»ãé žåãã©ãžãŠã ãã©ããŒãã
ã±ã«ãªã©ã®è±æ°ŽçŽ å觊åªãæããããããã®è±æ°Ž
çŽ å€ã®äœ¿çšéã¯ç¹ã«å¶éãããªãããããã²ã³å
å€ã®å Žåã«ã¯ãéåžžãååç©1iã«å¯ŸãïŒãïŒåã¢
ã«ã奜ãŸããã¯ïŒãïŒåã¢ã«çšããã®ããããè±
æ°ŽçŽ å觊åªã®å Žåã«ã¯äžè¬ã«éå°éçšããã®ãã
ããä»ã®è±æ°ŽçŽ å€ã®å Žåã«ãéåžžçã¢ã«ãéå°é
çšããã溶åªãšããŠã¯ããžãªããµã³ãããã©ãã
ããã©ã³ãã¡ããã·ãšã¿ããŒã«ããžã¡ããã·ãšã¿
ã³ãªã©ã®ãšãŒãã«é¡ããã³ãŒã³ããã«ãšã³ããã·
ã¬ã³ãã¯ã¡ã³ãªã©ã®è³éŠæçåæ°ŽçŽ é¡ããžã¯ãã
ã¡ã¿ã³ããžã¯ãããšã¿ã³ãã¯ãããã«ã ãåå¡©å
ççŽ ãªã©ã®ããã²ã³åçåæ°ŽçŽ é¡ããã¿ããŒã«ã
ã¢ãã«ã¢ã«ã³ãŒã«ããããµããŒã«ãªã©ã®ã¢ã«ã³ãŒ
ã«é¡ãé ¢é žãªã©ã®æ¥µæ§ãããã³æº¶åªããžã¡ãã«ã
ã«ã ã¢ããããžã¡ãã«ã¹ã«ããã·ãããããµã¡ã
ã«ãªã³é žããªã¢ãããªã©ã®éãããã³æ§æ¥µæ§æº¶åª
ãªã©ãæããããã該åå¿ã¯é垞宀枩ã300âã
奜ãŸããã¯å®€æž©ã200âã§è¡ãªãããäžè¬ã«ïŒã
40æéçšåºŠã§çµäºããã ãŸãååç©1kãéå ããã°ååç©1iã«å°ãããš
ãã§ãããã®éå åå¿ã¯éåžžã®æ¥è§Šéå ã«ããã
æ¡ä»¶ãé©çšãããäŸãã°é©åœãªæº¶åªäžã§éå±è§Šåª
ã®ååšäžã«è¡ãªãããã觊åªãšããŠã¯ãã©ãžãŠ
ã ããã©ãžãŠã ççŽ ããã©ãããã©ããŒããã±ã«
ãªã©ã®éå±è§Šåªãæããããéåžžã®è§Šåªéã«ãŠçš
ãããããçšãããã溶åªãšããŠã¯ãäŸãã°æ°Žã
ã¡ã¿ããŒã«ããšã¿ããŒã«ãã€ãœãããããŒã«ããž
ãªããµã³ãããã©ããããã©ã³ããããµã³ãã·ã¯
ããããµã³ãé ¢é žãšãã«ããŸãã¯ãããã®æ··å溶
åªãæããããã該åå¿ã¯åžžå§ããã³å å§äžã®ã
ããã§ãè¡ãªãåŸãããéåžžãåžžå§ã20KgïŒcm2ã
奜ãŸããã¯åžžå§ã10KgïŒcm2ã«ãŠãïŒã150âã奜
ãŸããã¯å®€æž©ã100âã§è¡ãªãããã äžè¬åŒ(1)ã®ååç©ã§R2ãæ°Žé žåºã§ããååç©
ã¯ãR2ãäœçŽã¢ã«ã³ãã·åºã§ããååç©ãèå
æ°ŽçŽ é žæ°Žæº¶æ¶²äžã§å ç±åŠçããŠè±ã¢ã«ãã«åãã
ããšã«ãã€ãŠã補é ã§ããããŸããR2ã眮æåº
ãšããŠããã²ã³ååãæããããšã®ãããã³ãŸã€
ã«ãªãã·ååç©ãå æ°Žå解ããããšã«ãã€ãŠã補
é ãããããã®å æ°Žå解ã¯é©åœãªæº¶åªäžé žãŸãã¯
å¡©åºæ§ååç©ã®ååšäžã«ãŠè¡ãªãããã溶åªãšã
ãŠã¯äŸãã°æ°Žãã¡ã¿ããŒã«ããšã¿ããŒã«ãã€ãœã
ããããŒã«ãªã©ã®äœçŽã¢ã«ã³ãŒã«é¡ããžãªããµ
ã³ãããã©ããããã©ã³ãªã©ã®ãšãŒãã«é¡ããã
ãã®æ··å溶åªãªã©ãæããããšãã§ãããé žãšã
ãŠã¯äŸãã°å¡©é žãç¡«é žãèåæ°ŽçŽ é žãªã©ã®é±é žé¡
ãããŸãå¡©åºæ§ååç©ãšããŠã¯äŸãã°æ°Žé žåãã
ãªãŠã ãæ°Žé žåã«ãªãŠã ãæ°Žé žåã«ã«ã·ãŠã ãªã©
ã®éå±æ°Žé žåç©ãªã©ãããããæããããšãã§ã
ãã該åå¿ã¯é垞宀枩ã150âã奜ãŸããã¯80ã
120âã«ãŠå¥œé©ã«é²è¡ããäžè¬ã«ïŒã15æéçšåºŠ
ã§çµäºããã ãŸããR2ãäœçŽã¢ã«ã³ãã·åºã®ååç©ã¯ã察
å¿ããR2ãæ°Žé žåºã®ååç©ãã¢ã«ãã«åããã
ãšã«ãã€ãŠãåŸãããšãåºæ¥ãããã®æ¹æ³ã§çšã
ãããã¢ã«ãã«åå€ãšããŠã¯ãã¡ãã«ã¢ã€ãªãã€
ãããšãã«ã¯ãã©ã€ããtertâããã«ãããã€ã
ãªã©ã®äœçŽã¢ã«ãã«ãã©ã€ããããã¯ç¡«é žãžã¡ã
ã«ãç¡«é žãžãšãã«ãªã©ãæãããããã®ä»ãžã¢ãŸ
ã¡ã¿ã³ãªã©ã®ã¢ã«ãã«åå€ã䜿çšããããšãåºæ¥
ãã該åå¿ã¯ãã¢ã»ãã³ãã¡ãã«ãšãã«ã±ãã³ãª
ã©ã®ã±ãã³é¡ããšãŒãã«ããžãªããµã³ãªã©ã®ãšãŒ
ãã«é¡ããã³ãŒã³ããã«ãšã³ããã·ã¬ã³ãªã©ã®è³
éŠæçåæ°ŽçŽ é¡ãæ°Žãããªãžã³ããžã¡ãã«ãã«ã
ã¢ããããžã¡ãã«ã¹ã«ãããµã€ãããããµã¡ãã«
ãªã³é žããªã¢ãããªã©ã®äžæŽ»æ§æº¶åªã䜿çšã§ãã
äžèšã¢ã·ã«ååå¿ã§äœ¿çšãããå¡©åºæ§ååç©ã®ä»
ã«ãé žåéãªã©ã觊åªãšããŠäœ¿çšã§ãããåå¿æž©
床ã¯ïŒâã溶åªã®æ²žç¹ã®ç¯å²ã§ãã¢ã«ãã«åå€ã®
䜿çšå²åã¯ãäžè¬åŒããã§R2ãæ°Žé žåºã®åå
ç©ã«å¯ŸããŠãïŒãïŒåã¢ã«éã®ç¯å²ã§ãããåå¿
ã¯ïŒã15æéçšåºŠã§çµäºããã ããã«ãR2ã眮æåºãšããŠããã²ã³ååãæ
ããããšã®ãããã³ãŸã€ã«ãªãã·åºã®ãã®ã¯ã察
å¿ããR2ãæ°Žé žåºã§ããååç©ãã¢ã·ã«åïŒã
ã³ãŸã€ã«åïŒããããšã«ãã€ãŠã補é ã§ãããã
ã®ã¢ã·ã«åå€ãšããŠã¯ãïœâã¯ãã«ãã³ãŸã€ã«ã¯
ãã©ã€ãããã³ãŸã€ã«ã¯ãã©ã€ãããã³ãŸã€ã«ã
ããã€ããªã©ã®å®æ¯éŠé žãã©ã€ããå®æ¯éŠé žç¡æ°Ž
ç©ãå®æ¯éŠé žãªã©ãæããããã該ã¢ã·ã«åå€ãš
ããŠé žç¡æ°Žç©ãŸãã¯é žãã©ã€ããçšããå Žåã«
ã¯ãã¢ã·ã«ååå¿ã¯å¡©åºæ§ååç©ã®ååšäžã«è¡ãª
ãããã䜿çšãããå¡©åºæ§ååç©ãšããŠã¯äŸãã°
éå±ãããªãŠã ãéå±ã«ãªãŠã ãªã©ã®ã¢ã«ã«ãªé
å±ããã³ãããã¢ã«ã«ãªéå±ã®æ°Žé žåç©ãçé ž
å¡©ãéçé žå¡©ãããã¯ããªãžã³ããããªãžã³ãªã©
ã®è³éŠæã¢ãã³ååç©ãªã©ãæããããã該åå¿
ã¯ç¡æº¶åªãããã¯æº¶åªäžã®ãããã§ãé²è¡ãã
ããéåžžã¯é©åœãªæº¶åªãçšããŠè¡ãªãããã溶åª
ãšããŠã¯äŸãã°ã¢ã»ãã³ãã¡ãã«ãšãã«ã±ãã³ãª
ã©ã®ã±ãã³é¡ããšãŒãã«ããžãªããµã³ãªã©ã®ãšãŒ
ãã«é¡ããã³ãŒã³ããã«ãšã³ããã·ã¬ã³ãªã©ã®è³
éŠæçåæ°ŽçŽ é¡ãæ°Žãããªãžã³ãªã©ãæããã
ããã¢ã·ã«åå€ã¯åæååç©ã«å¯ŸããŠå°ãªããšã
çã¢ã«çšããããããäžè¬ã«ã¯çã¢ã«ã倧éå°é
çšããã®ãããããŸã該åå¿ã¯ïŒã150âã§é²è¡
ããããäžè¬ã«ã¯ïŒã80âã§è¡ãªãã®ãããã åå¿æéã¯ã0.5ã10æéçšåºŠã§çµäºããããŸ
ãã¢ã·ã«åå€ãšããŠå®æ¯éŠé žã®ãããªé žã䜿çšã
ãå Žåãåå¿ç³»å ã«è±æ°Žå€ãšããŠç¡«é žãå¡©é žãªã©
ã®é±é žé¡ããã©ãã«ãšã³ã¹ã«ãã³é žããã³ãŒã³ã¹
ã«ãã³é žããšã¿ã³ã¹ã«ãã³é žãªã©ã®ã¹ã«ãã³é žé¡
ãæ·»å ãã奜ãŸããã¯50ã120âã«åå¿æž©åºŠãç¶
æããããšã«ããã¢ã·ã«ååå¿ã¯æå©ã«é²è¡ã
ãã ãªããæ¬çºæã®ååç©ïŒã®ãã¡ãR1ãæ°ŽçŽ å
åã§ãã€ã«ã«ãã¹ããªã«éªšæ žã®ïŒäœãšïŒäœéã®çµ
åãäºéçµåã§ããååç©ã¯äžèšã®åŒã§ç€ºããã
ããã«ã©ã¯ã¿ã âã©ã¯ãã åã®äºå€ç°æ§ããšãåŸ
ãã K0023 ãåŒäžãR2ïŒR3ïŒR4ïŒR5ïŒïŒ¡ããã³ïœã¯åèš
ã«åãã äžè¬åŒ(1)ã§è¡šããããååç©ã®ãã¡ãé žæ§åºã
æããååç©ã¯è¬ççã«èš±å®¹ãåŸãå¡©åºæ§ååç©
ãšå¡©ã圢æãåŸãããããå¡©åºæ§ååç©ãšããŠ
ã¯ãäŸãã°æ°Žé žåãããªãŠã ãæ°Žé žåã«ãªãŠã ã
æ°Žé žåã«ã«ã·ãŠã ãªã©ã®éå±æ°Žé žåç©ãçé žãã
ãªãŠã ãçé žæ°ŽçŽ ãããªãŠã ãªã©ã®ã¢ã«ã«ãªéå±
çé žå¡©ãŸãã¯éçé žå¡©ããããªãŠã ã¡ãã©ãŒãã
ã«ãªãŠã ãšãã©ãŒããªã©ã®ã¢ã«ã«ãªéå±ã¢ã«ã³ã©
ãŒããªã©ãæããããããŸãäžè¬åŒ(1)ã§è¡šããã
ãååç©ã®ãã¡ãå¡©åºæ§åºãæããååç©ã¯éåžž
ã®è¬ççã«èš±å®¹ãåŸãé žãšå®¹æã«å¡©ã圢æãåŸ
ãããããé žãšããŠã¯ãäŸãã°ãç¡«é žãç¡é žãå¡©
é žãèåæ°ŽçŽ é žãªã©ã®ç¡æ©é žãé ¢é žãïœâãã«ãš
ã³ã¹ã«ãã³é žããšã¿ã³ã¹ã«ãã³é žãã·ãŠãŠé žãã
ã¬ã€ã³é žãã³ãã¯é žãå®æ¯éŠé žãªã©ã®ææ©é žãæ
ããããã äžèšã®æ¹æ³ã§è£œé ãããæ¬çºæã®ååç©ã¯ãé
åžžã®åé¢æ段ãäŸãã°èžçæ³ãåçµæ¶æ³ãã«ã©ã
ã¯ãããã°ã©ãã€ããã¬ãã©ãã€ãèå±€ã¯ããã
ã°ã©ãã€ã溶åªæœåºæ³ãªã©ã«ãã容æã«åå¿ç³»ã
ããåé¢ã粟補ã§ããã åèšåå¿åŒâã®æ¹æ³ã«ãããŠåºçºåæãšããŠ
çšããããåŒ(2)ã®ååç©ã¯æ°èŠååç©ã§ãããäŸ
ãã°äžèšåå¿åŒâã«ç€ºãæ¹æ³ã§è£œé ã§ããã K0024 ååç©ïŒã«ååç©10ãåå¿ãããã°ææã®åå
ç©ïŒãããããããã®åå¿ã¯é©åœãªäžæŽ»æ§æº¶åª
äžãå¡©åºæ§ååç©ã®ååšäžã«ã宀枩ã200âã奜
ãŸããã¯60ã120âã«ãŠïŒã24æéçšåºŠã®æ¡ä»¶ã§
è¡ãªããããçšããããäžæŽ»æ§æº¶åªãšããŠã¯ãäŸ
ãã°ãžãªããµã³ãããã©ããããã©ã³ããšãã¬ã³
ã°ãªã³ãŒã«ããžã¡ãã«ãšãŒãã«ãªã©ã®ãšãŒãã«
é¡ããã³ãŒã³ããã«ãšã³ããã·ã¬ã³ãªã©ã®è³éŠæ
çåæ°ŽçŽ é¡ãã¡ã¿ããŒã«ããšã¿ããŒã«ãã€ãœãã
ãããŒã«ãªã©ã®äœçŽã¢ã«ã³ãŒã«é¡ããžã¡ãã«ãã«
ã ã¢ããããžã¡ãã«ã¹ã«ããã·ããªã©ã®æ¥µæ§æº¶åª
ãæãããããå¡©åºæ§ååç©ãšããŠã¯ãäŸãã°ç
é žã«ã«ã·ãŠã ãçé žãããªãŠã ãçé žã«ãªãŠã ã
çé žæ°ŽçŽ ãããªãŠã ãæ°Žé žåãããªãŠã ãæ°Žé žå
ã«ãªãŠã ããããªãŠã ã¢ãããæ°ŽçŽ åãããªãŠ
ã ãæ°ŽçŽ åã«ãªãŠã ããããªãŠã ã¡ãã©ãŒããã
ããªãŠã ãšãã©ãŒããªã©ã®ç¡æ©å¡©åºãããªãšãã«
ã¢ãã³ãããªãããã«ã¢ãã³ãããªãžã³ããããª
ã³ãªã©ã®ç¬¬ïŒçŽã¢ãã³é¡ãªã©ã®åºç¯å²ã®ãã®ãçš
ãããããäžèšã®åå¿ã¯ãå¿ èŠã«å¿ããŠåå¿ä¿é²
å€ãšããŠããšãŠåã«ãªãŠã ããšãŠåãããªãŠã ãª
ã©ã®ãšãŠåã¢ã«ã«ãªéå±ååç©ãæ·»å ããŠè¡ãªã€
ãŠããããååç©ïŒãšååç©10ã®äœ¿çšå²åã¯ç¹ã«
å¶éãããªãããéåžžåè ã«å¯ŸããŠåŸè ãçã¢ã«
ãéå°éã奜ãŸããã¯çã¢ã«ãïŒåã¢ã«ããã奜
ãŸããã¯çã¢ã«ã1.2åã¢ã«ã§ããã åŒ(2)ã®ååç©ãäžèšåå¿åŒâããã³ã«ç€ºã
æ¹æ³ã«ããä»ã®åŒ(2)ã®ååç©ã«å°ãããšãã§ã
ãã K0025 ãåŒäžãR2ïŒR7ïŒR8ïŒR9ïŒR1â²ïŒïŒžïŒïŒ¡ïŒïœã
ãã³ã«ã«ãã¹ããªã«éªšæ žã®ïŒäœãšïŒäœéã®çµåã¯
åèšã«åãã äžèšåå¿åŒâã«ãããååç©2aãšã¢ã«ãã«
åå€ãšã®åå¿ã¯åèšåå¿åŒâã«ãããååç©
1gã®ã¢ã«ãã«ååå¿ãšåãåå¿æ¡ä»¶ã«ãŠè¡ãªã
ããã K0026 ãåŒäžãR1ïŒR2ïŒR7ïŒR8ïŒR9ïŒïŒ¡ããã³ïœã¯
åèšã«åãã äžèšåå¿åŒâã«ãããè±æ°ŽçŽ åå¿ããã³éå
åå¿ã¯ããããåèšåå¿åŒâã«ãããååç©1i
ã®è±æ°ŽçŽ åå¿ããã³ååç©1kã®éå åå¿ãšåã
åå¿æ¡ä»¶äžã«è¡ãªãããã åèšåå¿åŒâã«ãããåºçºç©è³ªã®åŒ(6)ã®åå
ç©ã¯äžéšå ¬ç¥ã§ãããäžéšæ°èŠååç©ãå«ã¿ãäŸ
ãã°äžèšåå¿åŒâã«ç€ºãæ¹æ³ã§è£œé ã§ããã K0027 ãåŒäžãR2ã¯åèšã«åãã äžèšåå¿åŒäžãååç©11ãéç°ãããŠååç©12
ã«å°ãåå¿ã¯ãïŒïŒ®â眮æãã«ã ã¢ãããšé žè§Š
åªïŒäžè¬ã«ãŽã€ã«ã¹ãã€ã€ãŒè©Šè¬ãšåŒã°ããïŒã®
ååšäžã«é©åœãªæº¶åªäžãŸãã¯æº¶åªã®éååšäžã«è¡
ãªããããããã§äœ¿çšãããïŒïŒ®â眮æãã«ã
ã¢ãããšããŠã¯ãïŒïŒ®âãžã¡ãã«ãã«ã ã¢ã
ããïŒïŒ®âãžãšãã«ãã«ã ã¢ãããâãšãã«
ââã¡ãã«ãã«ã ã¢ãããâã¡ãã«ââã
ãšãã«ãã«ã ã¢ãããªã©ãäŸç€ºã§ãããé žè§Šåªãš
ããŠã¯ããªãã·å¡©åãªã³ãããªãã«ã¯ãã©ã€ãã
ããªã¹ã²ã³ãªã©ãäŸç€ºã§ããã䜿çšããã溶åªãš
ããŠã¯ãã¯ãããã«ã ãïŒïŒïŒâãžã¯ãããšã¿
ã³ãïŒïŒïŒâãžã¯ãããšãã¬ã³ãªã©ã®ããã²ã³å
çåæ°ŽçŽ é¡ãã¯ãããã³ãŒã³ãïŒïŒïŒâãžã¯ãã
ãã³ãŒã³ãªã©ã®è³éŠæçåæ°ŽçŽ é¡ãªã©ãäŸç€ºã§ã
ããïŒïŒ®â眮æãã«ã ã¢ãããšé žè§Šåªã®äœ¿çšé
ã¯ãäžè¬åŒ(11)ã®ååç©ã«å¯ŸããŠãé垞倧éå°éã
奜ãŸããã¯ãåè ã¯ïŒãïŒåã¢ã«ãåŸè ã¯ïŒã10
åã¢ã«é䜿çšããã®ããããåå¿æž©åºŠã¯éåžžïŒã
150âã奜ãŸããã¯50ã100âä»è¿ã§è¡ãªãã®ãã
ããåå¿ã¯ïŒã24æéçšåºŠã§çµäºããã ãŸãååç©12ããååç©6aãããåå¿ã¯ãå
åç©12ãäŸãã°å¡©é žãèåæ°ŽçŽ é žãªã©ã®ããã²ã³
åæ°ŽçŽ é žé¡ãç¡«é žããªã³é žãªã©ã®ç¡æ©é žé¡ãæ°Žé ž
åã«ãªãŠã ãæ°Žé žåãããªãŠã ãªã©ã®ã¢ã«ã«ãªé
å±æ°Žé žåç©ãçé žãããªãŠã ãçé žã«ãªãŠã ãç
é žæ°ŽçŽ ã«ãªãŠã ãªã©ã®ç¡æ©ã¢ã«ã«ãªååç©ããã
ãã¯é ¢é žãªã©ã®ææ©é žã®ååšäžã«ã50ã150âã
奜ãŸããã¯70ã120âã«ãŠã0.5ã24æéçšåºŠå ç±
ããããšã«ããéæãããã åèšåå¿åŒâã§åºçºç©è³ªãšããŠçšããããå
åç©ïŒã¯äžèšåå¿åŒâXIã®æ¹æ³ã§è£œé ãããã K0028 K0029 ãåŒäžãR1ïŒR2ïŒïŒ¡ïŒïœããã³ã«ã«ãã¹ããª
ã«éªšæ žã®ïŒäœãšïŒäœéã®çµåã¯åèšã«åããR10
ã¯äœçŽã¢ã«ãã«ãŸãã¯
ã«ã察å¿ããäºéçµåãæããååç©ãéå ãã
ããšã«ãã補é ã§ããã K0019 ãåŒäžãR1ïŒR2ïŒR3ïŒR4ïŒR5ïŒïŒ¡ïŒïœããã³
ã«ã«ãã¹ããªã«éªšæ žã®ïŒäœãšïŒäœéã®çµåã¯åèš
ã«åãã äžèšã®éå åå¿ã¯ãéåžžãé©åœãªéå 觊åªã®å
åšäžã«æ¥è§Šéå ããããšã«ããè¡ãªããããçšã
ãããéå 觊åªãšããŠã¯ãäŸãã°çœéãé žåçœ
éããã©ãžãŠã é»ããã©ãžãŠã ççŽ ãã©ããŒãã
ã±ã«ãªã©ã®éåžžã®æ¥è§Šéå çšè§Šåªãå«ãŸãããã®
䜿çšéã¯ååç©ïŒâ²ã«å¯ŸããéåžžçŽ0.2ã0.5åé
éã®ç¯å²ã§ããããã®æ¥è§Šéå ã¯ãäŸãã°æ°Žãã¡
ã¿ããŒã«ããšã¿ããŒã«ãã€ãœãããããŒã«ããã
ã©ããããã©ã³ããšãã«ãšãŒãã«ãªã©ã®æº¶åªäžã
ïŒã10æ°å§ã奜ãŸããã¯ïŒãïŒæ°å§ã®æ°ŽçŽ é°å²æ°
äžãâ30âã溶åªã®æ²žç¹æž©åºŠã奜ãŸããã¯ïŒâã
宀枩ä»è¿ã«ãŠãããæ¯ãæ··ããããšã«ããè¡ãªã
ããã ããã«ãæ¬çºæã®ååç©ãäžèšåå¿åŒâã
ã«ç€ºãæ¹æ³ã«ããä»ã®æ¬çºæååç©ã«å°ãããšã
ã§ããã K0020 ãåŒäžãR1ïŒR3ïŒR4ïŒR5ïŒïŒ¡ïŒïœããã³ã«ã«
ãã¹ããªã«éªšæ žã®ïŒäœãšïŒäœéã®çµåã¯åèšã«å
ããR2â²ã¯äœçŽã¢ã«ã³ãã·ã瀺ãã äžèšåå¿åŒâã«ç€ºãååç©1eãååç©1fã«å°
ãåå¿ã¯ãååç©1eãèåæ°ŽçŽ é žæ°Žæº¶æ¶²äžã§50ã
150âã«ãŠïŒã10æéçšåºŠå ç±åŠçããããšã«ã
ãè¡ãªãããã K0021 ãåŒäžãR2ïŒR3ïŒR4ïŒR5ïŒïŒ¡ïŒïœããã³ã«ã«
ãã¹ããªã«éªšæ žã®ïŒäœãšïŒäœéã®çµåã¯åèšã«å
ããR1â²ã¯äœçŽã¢ã«ãã«ãäœçŽã¢ã«ã±ãã«ãäœçŽ
ã¢ã«ããã«ãŸãã¯ããšãã«äœçŽã¢ã«ãã«ã瀺ãã äžèšååç©1gã®ã¢ã«ãã«ååå¿ã¯ãäŸãã°æ°Ž
çŽ åãããªãŠã ãæ°ŽçŽ åã«ãªãŠã ãéå±ã«ãªãŠ
ã ãéå±ãããªãŠã ããããªãŠã ã¢ãããã«ãªãŠ
ã ã¢ãããæ°Žé žåãããªãŠã ãæ°Žé žåã«ãªãŠã ã
çé žãããªãŠã ãçé žã«ãªãŠã ãçé žæ°ŽçŽ ãããª
ãŠã ãçé žæ°ŽçŽ ã«ãªãŠã ãªã©ã®å¡©åºæ§ååç©ã®å
åšäžãé©åœãªæº¶åªäžã«ãŠè¡ãªããããçšãããã
溶åªãšããŠã¯ãäŸãã°ãžãªããµã³ãããã©ããã
ãã©ã³ããžãšãã«ãšãŒãã«ããžãšãã¬ã³ã°ãªã³ãŒ
ã«ãžã¡ãã«ãšãŒãã«ãããã©ããããã©ã³ãªã©ã®
ãšãŒãã«é¡ããã³ãŒã³ããã«ãšã³ããã·ã¬ã³ãã¯
ãããã³ãŒã³ãªã©ã®è³éŠæçåæ°ŽçŽ é¡ããžã¡ãã«
ãã«ã ã¢ããããžã¡ãã«ã¹ã«ããã·ãããããµã¡
ãã«ãªã³é žããªã¢ãããã¢ã³ã¢ãã¢æ°Žãªã©ãŸãã¯
ãããã®æ··å溶åªãæãããããã¢ã«ãã«åå€ãš
ããŠã¯ãäžè¬åŒR1â²XïŒR1â²ã¯åèšã«åããã¯ã
ãã²ã³ååïŒã®ããã²ã³åã¢ã«ãã«ããžã¡ãã«ç¡«
é žããžãšãã«ç¡«é žãªã©ã®ãžã¢ã«ãã«ç¡«é žããã³ãž
ã«ïœâãã«ãšã³ã¹ã«ãããŒããã¡ãã«ïœâãã«ãš
ã³ã¹ã«ãããŒããªã©ã®ãã«ãšã³ã¹ã«ãããŒãé¡ãª
ã©ãæãããããã®äœ¿çšå²åã¯ç¹ã«éå®ãããªã
ããéåžžååç©1gã«å¯Ÿãå°ãªããšãçã¢ã«ã奜
ãŸããã¯çã¢ã«ãïŒåã¢ã«ã§ããã該åå¿ã¯éåžž
ïŒã70âçšåºŠã奜ãŸããã¯ïŒâã宀枩ä»è¿ã§è¡ãª
ãããäžè¬ã«30åã12æéçšåºŠã§çµäºããã K0022 ãåŒäžãR1ïŒR2ïŒR3ïŒR4ïŒR5ïŒïŒ¡ããã³ïœã¯
åèšã«åãã äžèšã®ååç©1iãè±æ°ŽçŽ ããŠååç©1kã«å°ãå
å¿ã¯ãé©åœãªæº¶åªäžã§è±æ°ŽçŽ å€ã§åŠçããŠè¡ãªã
ãããè±æ°ŽçŽ å€ãšããŠã¯ãäŸãã°ïŒïŒïŒâãžã¯ã
ãâïŒïŒïŒâãžã·ã¢ããã³ãŸããã³ãïŒïŒïŒïŒ
ïŒïŒïŒâããã©ã¯ãããã³ãŸããã³ïŒäžè¬åã¯ã
ã©ãã«ïŒãªã©ã®ãã³ãŸããã³é¡ãâããã¢ã³ã
ã¯é žã€ãããâã¯ããã³ãã¯é žã€ãããèçŽ ãª
ã©ã®ããã²ã³åå€ãäºé žåã»ã¬ã³ããã©ãžãŠã ç
çŽ ããã©ãžãŠã é»ãé žåãã©ãžãŠã ãã©ããŒãã
ã±ã«ãªã©ã®è±æ°ŽçŽ å觊åªãæããããããã®è±æ°Ž
çŽ å€ã®äœ¿çšéã¯ç¹ã«å¶éãããªãããããã²ã³å
å€ã®å Žåã«ã¯ãéåžžãååç©1iã«å¯ŸãïŒãïŒåã¢
ã«ã奜ãŸããã¯ïŒãïŒåã¢ã«çšããã®ããããè±
æ°ŽçŽ å觊åªã®å Žåã«ã¯äžè¬ã«éå°éçšããã®ãã
ããä»ã®è±æ°ŽçŽ å€ã®å Žåã«ãéåžžçã¢ã«ãéå°é
çšããã溶åªãšããŠã¯ããžãªããµã³ãããã©ãã
ããã©ã³ãã¡ããã·ãšã¿ããŒã«ããžã¡ããã·ãšã¿
ã³ãªã©ã®ãšãŒãã«é¡ããã³ãŒã³ããã«ãšã³ããã·
ã¬ã³ãã¯ã¡ã³ãªã©ã®è³éŠæçåæ°ŽçŽ é¡ããžã¯ãã
ã¡ã¿ã³ããžã¯ãããšã¿ã³ãã¯ãããã«ã ãåå¡©å
ççŽ ãªã©ã®ããã²ã³åçåæ°ŽçŽ é¡ããã¿ããŒã«ã
ã¢ãã«ã¢ã«ã³ãŒã«ããããµããŒã«ãªã©ã®ã¢ã«ã³ãŒ
ã«é¡ãé ¢é žãªã©ã®æ¥µæ§ãããã³æº¶åªããžã¡ãã«ã
ã«ã ã¢ããããžã¡ãã«ã¹ã«ããã·ãããããµã¡ã
ã«ãªã³é žããªã¢ãããªã©ã®éãããã³æ§æ¥µæ§æº¶åª
ãªã©ãæããããã該åå¿ã¯é垞宀枩ã300âã
奜ãŸããã¯å®€æž©ã200âã§è¡ãªãããäžè¬ã«ïŒã
40æéçšåºŠã§çµäºããã ãŸãååç©1kãéå ããã°ååç©1iã«å°ãããš
ãã§ãããã®éå åå¿ã¯éåžžã®æ¥è§Šéå ã«ããã
æ¡ä»¶ãé©çšãããäŸãã°é©åœãªæº¶åªäžã§éå±è§Šåª
ã®ååšäžã«è¡ãªãããã觊åªãšããŠã¯ãã©ãžãŠ
ã ããã©ãžãŠã ççŽ ããã©ãããã©ããŒããã±ã«
ãªã©ã®éå±è§Šåªãæããããéåžžã®è§Šåªéã«ãŠçš
ãããããçšãããã溶åªãšããŠã¯ãäŸãã°æ°Žã
ã¡ã¿ããŒã«ããšã¿ããŒã«ãã€ãœãããããŒã«ããž
ãªããµã³ãããã©ããããã©ã³ããããµã³ãã·ã¯
ããããµã³ãé ¢é žãšãã«ããŸãã¯ãããã®æ··å溶
åªãæããããã該åå¿ã¯åžžå§ããã³å å§äžã®ã
ããã§ãè¡ãªãåŸãããéåžžãåžžå§ã20KgïŒcm2ã
奜ãŸããã¯åžžå§ã10KgïŒcm2ã«ãŠãïŒã150âã奜
ãŸããã¯å®€æž©ã100âã§è¡ãªãããã äžè¬åŒ(1)ã®ååç©ã§R2ãæ°Žé žåºã§ããååç©
ã¯ãR2ãäœçŽã¢ã«ã³ãã·åºã§ããååç©ãèå
æ°ŽçŽ é žæ°Žæº¶æ¶²äžã§å ç±åŠçããŠè±ã¢ã«ãã«åãã
ããšã«ãã€ãŠã補é ã§ããããŸããR2ã眮æåº
ãšããŠããã²ã³ååãæããããšã®ãããã³ãŸã€
ã«ãªãã·ååç©ãå æ°Žå解ããããšã«ãã€ãŠã補
é ãããããã®å æ°Žå解ã¯é©åœãªæº¶åªäžé žãŸãã¯
å¡©åºæ§ååç©ã®ååšäžã«ãŠè¡ãªãããã溶åªãšã
ãŠã¯äŸãã°æ°Žãã¡ã¿ããŒã«ããšã¿ããŒã«ãã€ãœã
ããããŒã«ãªã©ã®äœçŽã¢ã«ã³ãŒã«é¡ããžãªããµ
ã³ãããã©ããããã©ã³ãªã©ã®ãšãŒãã«é¡ããã
ãã®æ··å溶åªãªã©ãæããããšãã§ãããé žãšã
ãŠã¯äŸãã°å¡©é žãç¡«é žãèåæ°ŽçŽ é žãªã©ã®é±é žé¡
ãããŸãå¡©åºæ§ååç©ãšããŠã¯äŸãã°æ°Žé žåãã
ãªãŠã ãæ°Žé žåã«ãªãŠã ãæ°Žé žåã«ã«ã·ãŠã ãªã©
ã®éå±æ°Žé žåç©ãªã©ãããããæããããšãã§ã
ãã該åå¿ã¯é垞宀枩ã150âã奜ãŸããã¯80ã
120âã«ãŠå¥œé©ã«é²è¡ããäžè¬ã«ïŒã15æéçšåºŠ
ã§çµäºããã ãŸããR2ãäœçŽã¢ã«ã³ãã·åºã®ååç©ã¯ã察
å¿ããR2ãæ°Žé žåºã®ååç©ãã¢ã«ãã«åããã
ãšã«ãã€ãŠãåŸãããšãåºæ¥ãããã®æ¹æ³ã§çšã
ãããã¢ã«ãã«åå€ãšããŠã¯ãã¡ãã«ã¢ã€ãªãã€
ãããšãã«ã¯ãã©ã€ããtertâããã«ãããã€ã
ãªã©ã®äœçŽã¢ã«ãã«ãã©ã€ããããã¯ç¡«é žãžã¡ã
ã«ãç¡«é žãžãšãã«ãªã©ãæãããããã®ä»ãžã¢ãŸ
ã¡ã¿ã³ãªã©ã®ã¢ã«ãã«åå€ã䜿çšããããšãåºæ¥
ãã該åå¿ã¯ãã¢ã»ãã³ãã¡ãã«ãšãã«ã±ãã³ãª
ã©ã®ã±ãã³é¡ããšãŒãã«ããžãªããµã³ãªã©ã®ãšãŒ
ãã«é¡ããã³ãŒã³ããã«ãšã³ããã·ã¬ã³ãªã©ã®è³
éŠæçåæ°ŽçŽ é¡ãæ°Žãããªãžã³ããžã¡ãã«ãã«ã
ã¢ããããžã¡ãã«ã¹ã«ãããµã€ãããããµã¡ãã«
ãªã³é žããªã¢ãããªã©ã®äžæŽ»æ§æº¶åªã䜿çšã§ãã
äžèšã¢ã·ã«ååå¿ã§äœ¿çšãããå¡©åºæ§ååç©ã®ä»
ã«ãé žåéãªã©ã觊åªãšããŠäœ¿çšã§ãããåå¿æž©
床ã¯ïŒâã溶åªã®æ²žç¹ã®ç¯å²ã§ãã¢ã«ãã«åå€ã®
䜿çšå²åã¯ãäžè¬åŒããã§R2ãæ°Žé žåºã®åå
ç©ã«å¯ŸããŠãïŒãïŒåã¢ã«éã®ç¯å²ã§ãããåå¿
ã¯ïŒã15æéçšåºŠã§çµäºããã ããã«ãR2ã眮æåºãšããŠããã²ã³ååãæ
ããããšã®ãããã³ãŸã€ã«ãªãã·åºã®ãã®ã¯ã察
å¿ããR2ãæ°Žé žåºã§ããååç©ãã¢ã·ã«åïŒã
ã³ãŸã€ã«åïŒããããšã«ãã€ãŠã補é ã§ãããã
ã®ã¢ã·ã«åå€ãšããŠã¯ãïœâã¯ãã«ãã³ãŸã€ã«ã¯
ãã©ã€ãããã³ãŸã€ã«ã¯ãã©ã€ãããã³ãŸã€ã«ã
ããã€ããªã©ã®å®æ¯éŠé žãã©ã€ããå®æ¯éŠé žç¡æ°Ž
ç©ãå®æ¯éŠé žãªã©ãæããããã該ã¢ã·ã«åå€ãš
ããŠé žç¡æ°Žç©ãŸãã¯é žãã©ã€ããçšããå Žåã«
ã¯ãã¢ã·ã«ååå¿ã¯å¡©åºæ§ååç©ã®ååšäžã«è¡ãª
ãããã䜿çšãããå¡©åºæ§ååç©ãšããŠã¯äŸãã°
éå±ãããªãŠã ãéå±ã«ãªãŠã ãªã©ã®ã¢ã«ã«ãªé
å±ããã³ãããã¢ã«ã«ãªéå±ã®æ°Žé žåç©ãçé ž
å¡©ãéçé žå¡©ãããã¯ããªãžã³ããããªãžã³ãªã©
ã®è³éŠæã¢ãã³ååç©ãªã©ãæããããã該åå¿
ã¯ç¡æº¶åªãããã¯æº¶åªäžã®ãããã§ãé²è¡ãã
ããéåžžã¯é©åœãªæº¶åªãçšããŠè¡ãªãããã溶åª
ãšããŠã¯äŸãã°ã¢ã»ãã³ãã¡ãã«ãšãã«ã±ãã³ãª
ã©ã®ã±ãã³é¡ããšãŒãã«ããžãªããµã³ãªã©ã®ãšãŒ
ãã«é¡ããã³ãŒã³ããã«ãšã³ããã·ã¬ã³ãªã©ã®è³
éŠæçåæ°ŽçŽ é¡ãæ°Žãããªãžã³ãªã©ãæããã
ããã¢ã·ã«åå€ã¯åæååç©ã«å¯ŸããŠå°ãªããšã
çã¢ã«çšããããããäžè¬ã«ã¯çã¢ã«ã倧éå°é
çšããã®ãããããŸã該åå¿ã¯ïŒã150âã§é²è¡
ããããäžè¬ã«ã¯ïŒã80âã§è¡ãªãã®ãããã åå¿æéã¯ã0.5ã10æéçšåºŠã§çµäºããããŸ
ãã¢ã·ã«åå€ãšããŠå®æ¯éŠé žã®ãããªé žã䜿çšã
ãå Žåãåå¿ç³»å ã«è±æ°Žå€ãšããŠç¡«é žãå¡©é žãªã©
ã®é±é žé¡ããã©ãã«ãšã³ã¹ã«ãã³é žããã³ãŒã³ã¹
ã«ãã³é žããšã¿ã³ã¹ã«ãã³é žãªã©ã®ã¹ã«ãã³é žé¡
ãæ·»å ãã奜ãŸããã¯50ã120âã«åå¿æž©åºŠãç¶
æããããšã«ããã¢ã·ã«ååå¿ã¯æå©ã«é²è¡ã
ãã ãªããæ¬çºæã®ååç©ïŒã®ãã¡ãR1ãæ°ŽçŽ å
åã§ãã€ã«ã«ãã¹ããªã«éªšæ žã®ïŒäœãšïŒäœéã®çµ
åãäºéçµåã§ããååç©ã¯äžèšã®åŒã§ç€ºããã
ããã«ã©ã¯ã¿ã âã©ã¯ãã åã®äºå€ç°æ§ããšãåŸ
ãã K0023 ãåŒäžãR2ïŒR3ïŒR4ïŒR5ïŒïŒ¡ããã³ïœã¯åèš
ã«åãã äžè¬åŒ(1)ã§è¡šããããååç©ã®ãã¡ãé žæ§åºã
æããååç©ã¯è¬ççã«èš±å®¹ãåŸãå¡©åºæ§ååç©
ãšå¡©ã圢æãåŸãããããå¡©åºæ§ååç©ãšããŠ
ã¯ãäŸãã°æ°Žé žåãããªãŠã ãæ°Žé žåã«ãªãŠã ã
æ°Žé žåã«ã«ã·ãŠã ãªã©ã®éå±æ°Žé žåç©ãçé žãã
ãªãŠã ãçé žæ°ŽçŽ ãããªãŠã ãªã©ã®ã¢ã«ã«ãªéå±
çé žå¡©ãŸãã¯éçé žå¡©ããããªãŠã ã¡ãã©ãŒãã
ã«ãªãŠã ãšãã©ãŒããªã©ã®ã¢ã«ã«ãªéå±ã¢ã«ã³ã©
ãŒããªã©ãæããããããŸãäžè¬åŒ(1)ã§è¡šããã
ãååç©ã®ãã¡ãå¡©åºæ§åºãæããååç©ã¯éåžž
ã®è¬ççã«èš±å®¹ãåŸãé žãšå®¹æã«å¡©ã圢æãåŸ
ãããããé žãšããŠã¯ãäŸãã°ãç¡«é žãç¡é žãå¡©
é žãèåæ°ŽçŽ é žãªã©ã®ç¡æ©é žãé ¢é žãïœâãã«ãš
ã³ã¹ã«ãã³é žããšã¿ã³ã¹ã«ãã³é žãã·ãŠãŠé žãã
ã¬ã€ã³é žãã³ãã¯é žãå®æ¯éŠé žãªã©ã®ææ©é žãæ
ããããã äžèšã®æ¹æ³ã§è£œé ãããæ¬çºæã®ååç©ã¯ãé
åžžã®åé¢æ段ãäŸãã°èžçæ³ãåçµæ¶æ³ãã«ã©ã
ã¯ãããã°ã©ãã€ããã¬ãã©ãã€ãèå±€ã¯ããã
ã°ã©ãã€ã溶åªæœåºæ³ãªã©ã«ãã容æã«åå¿ç³»ã
ããåé¢ã粟補ã§ããã åèšåå¿åŒâã®æ¹æ³ã«ãããŠåºçºåæãšããŠ
çšããããåŒ(2)ã®ååç©ã¯æ°èŠååç©ã§ãããäŸ
ãã°äžèšåå¿åŒâã«ç€ºãæ¹æ³ã§è£œé ã§ããã K0024 ååç©ïŒã«ååç©10ãåå¿ãããã°ææã®åå
ç©ïŒãããããããã®åå¿ã¯é©åœãªäžæŽ»æ§æº¶åª
äžãå¡©åºæ§ååç©ã®ååšäžã«ã宀枩ã200âã奜
ãŸããã¯60ã120âã«ãŠïŒã24æéçšåºŠã®æ¡ä»¶ã§
è¡ãªããããçšããããäžæŽ»æ§æº¶åªãšããŠã¯ãäŸ
ãã°ãžãªããµã³ãããã©ããããã©ã³ããšãã¬ã³
ã°ãªã³ãŒã«ããžã¡ãã«ãšãŒãã«ãªã©ã®ãšãŒãã«
é¡ããã³ãŒã³ããã«ãšã³ããã·ã¬ã³ãªã©ã®è³éŠæ
çåæ°ŽçŽ é¡ãã¡ã¿ããŒã«ããšã¿ããŒã«ãã€ãœãã
ãããŒã«ãªã©ã®äœçŽã¢ã«ã³ãŒã«é¡ããžã¡ãã«ãã«
ã ã¢ããããžã¡ãã«ã¹ã«ããã·ããªã©ã®æ¥µæ§æº¶åª
ãæãããããå¡©åºæ§ååç©ãšããŠã¯ãäŸãã°ç
é žã«ã«ã·ãŠã ãçé žãããªãŠã ãçé žã«ãªãŠã ã
çé žæ°ŽçŽ ãããªãŠã ãæ°Žé žåãããªãŠã ãæ°Žé žå
ã«ãªãŠã ããããªãŠã ã¢ãããæ°ŽçŽ åãããªãŠ
ã ãæ°ŽçŽ åã«ãªãŠã ããããªãŠã ã¡ãã©ãŒããã
ããªãŠã ãšãã©ãŒããªã©ã®ç¡æ©å¡©åºãããªãšãã«
ã¢ãã³ãããªãããã«ã¢ãã³ãããªãžã³ããããª
ã³ãªã©ã®ç¬¬ïŒçŽã¢ãã³é¡ãªã©ã®åºç¯å²ã®ãã®ãçš
ãããããäžèšã®åå¿ã¯ãå¿ èŠã«å¿ããŠåå¿ä¿é²
å€ãšããŠããšãŠåã«ãªãŠã ããšãŠåãããªãŠã ãª
ã©ã®ãšãŠåã¢ã«ã«ãªéå±ååç©ãæ·»å ããŠè¡ãªã€
ãŠããããååç©ïŒãšååç©10ã®äœ¿çšå²åã¯ç¹ã«
å¶éãããªãããéåžžåè ã«å¯ŸããŠåŸè ãçã¢ã«
ãéå°éã奜ãŸããã¯çã¢ã«ãïŒåã¢ã«ããã奜
ãŸããã¯çã¢ã«ã1.2åã¢ã«ã§ããã åŒ(2)ã®ååç©ãäžèšåå¿åŒâããã³ã«ç€ºã
æ¹æ³ã«ããä»ã®åŒ(2)ã®ååç©ã«å°ãããšãã§ã
ãã K0025 ãåŒäžãR2ïŒR7ïŒR8ïŒR9ïŒR1â²ïŒïŒžïŒïŒ¡ïŒïœã
ãã³ã«ã«ãã¹ããªã«éªšæ žã®ïŒäœãšïŒäœéã®çµåã¯
åèšã«åãã äžèšåå¿åŒâã«ãããååç©2aãšã¢ã«ãã«
åå€ãšã®åå¿ã¯åèšåå¿åŒâã«ãããååç©
1gã®ã¢ã«ãã«ååå¿ãšåãåå¿æ¡ä»¶ã«ãŠè¡ãªã
ããã K0026 ãåŒäžãR1ïŒR2ïŒR7ïŒR8ïŒR9ïŒïŒ¡ããã³ïœã¯
åèšã«åãã äžèšåå¿åŒâã«ãããè±æ°ŽçŽ åå¿ããã³éå
åå¿ã¯ããããåèšåå¿åŒâã«ãããååç©1i
ã®è±æ°ŽçŽ åå¿ããã³ååç©1kã®éå åå¿ãšåã
åå¿æ¡ä»¶äžã«è¡ãªãããã åèšåå¿åŒâã«ãããåºçºç©è³ªã®åŒ(6)ã®åå
ç©ã¯äžéšå ¬ç¥ã§ãããäžéšæ°èŠååç©ãå«ã¿ãäŸ
ãã°äžèšåå¿åŒâã«ç€ºãæ¹æ³ã§è£œé ã§ããã K0027 ãåŒäžãR2ã¯åèšã«åãã äžèšåå¿åŒäžãååç©11ãéç°ãããŠååç©12
ã«å°ãåå¿ã¯ãïŒïŒ®â眮æãã«ã ã¢ãããšé žè§Š
åªïŒäžè¬ã«ãŽã€ã«ã¹ãã€ã€ãŒè©Šè¬ãšåŒã°ããïŒã®
ååšäžã«é©åœãªæº¶åªäžãŸãã¯æº¶åªã®éååšäžã«è¡
ãªããããããã§äœ¿çšãããïŒïŒ®â眮æãã«ã
ã¢ãããšããŠã¯ãïŒïŒ®âãžã¡ãã«ãã«ã ã¢ã
ããïŒïŒ®âãžãšãã«ãã«ã ã¢ãããâãšãã«
ââã¡ãã«ãã«ã ã¢ãããâã¡ãã«ââã
ãšãã«ãã«ã ã¢ãããªã©ãäŸç€ºã§ãããé žè§Šåªãš
ããŠã¯ããªãã·å¡©åãªã³ãããªãã«ã¯ãã©ã€ãã
ããªã¹ã²ã³ãªã©ãäŸç€ºã§ããã䜿çšããã溶åªãš
ããŠã¯ãã¯ãããã«ã ãïŒïŒïŒâãžã¯ãããšã¿
ã³ãïŒïŒïŒâãžã¯ãããšãã¬ã³ãªã©ã®ããã²ã³å
çåæ°ŽçŽ é¡ãã¯ãããã³ãŒã³ãïŒïŒïŒâãžã¯ãã
ãã³ãŒã³ãªã©ã®è³éŠæçåæ°ŽçŽ é¡ãªã©ãäŸç€ºã§ã
ããïŒïŒ®â眮æãã«ã ã¢ãããšé žè§Šåªã®äœ¿çšé
ã¯ãäžè¬åŒ(11)ã®ååç©ã«å¯ŸããŠãé垞倧éå°éã
奜ãŸããã¯ãåè ã¯ïŒãïŒåã¢ã«ãåŸè ã¯ïŒã10
åã¢ã«é䜿çšããã®ããããåå¿æž©åºŠã¯éåžžïŒã
150âã奜ãŸããã¯50ã100âä»è¿ã§è¡ãªãã®ãã
ããåå¿ã¯ïŒã24æéçšåºŠã§çµäºããã ãŸãååç©12ããååç©6aãããåå¿ã¯ãå
åç©12ãäŸãã°å¡©é žãèåæ°ŽçŽ é žãªã©ã®ããã²ã³
åæ°ŽçŽ é žé¡ãç¡«é žããªã³é žãªã©ã®ç¡æ©é žé¡ãæ°Žé ž
åã«ãªãŠã ãæ°Žé žåãããªãŠã ãªã©ã®ã¢ã«ã«ãªé
å±æ°Žé žåç©ãçé žãããªãŠã ãçé žã«ãªãŠã ãç
é žæ°ŽçŽ ã«ãªãŠã ãªã©ã®ç¡æ©ã¢ã«ã«ãªååç©ããã
ãã¯é ¢é žãªã©ã®ææ©é žã®ååšäžã«ã50ã150âã
奜ãŸããã¯70ã120âã«ãŠã0.5ã24æéçšåºŠå ç±
ããããšã«ããéæãããã åèšåå¿åŒâã§åºçºç©è³ªãšããŠçšããããå
åç©ïŒã¯äžèšåå¿åŒâXIã®æ¹æ³ã§è£œé ãããã K0028 K0029 ãåŒäžãR1ïŒR2ïŒïŒ¡ïŒïœããã³ã«ã«ãã¹ããª
ã«éªšæ žã®ïŒäœãšïŒäœéã®çµåã¯åèšã«åããR10
ã¯äœçŽã¢ã«ãã«ãŸãã¯
ãåŒãã¯ããã²
ã³ååã瀺ãã
äžèšåå¿åŒâXIã«ãããŠãååç©13ãšååç©14
ãšã®åå¿ã¯ãåèšåå¿åŒâã«ãããååç©1a
ãŸãã¯1bã®ååç©ïŒã«ãããšã¹ãã«ååå¿ãšå š
ãåæ§ã®åå¿æ¡ä»¶äžã«è¡ãªãããšãã§ããã 該ãšã¹ãã«åã«ããããããååç©15ãéå ã
ãŠå¯Ÿå¿ããååç©ïŒïŒã«å°ãããšãã§ããããªã
ãã®ååç©ïŒïŒã¯ååç©13ãçŽæ¥éå ããŠããã
ããããããã®éå åå¿ã¯ãéåžžãæ°ŽçŽ åéå å€
ãçšããŠè¡ãªãããããã®æ°ŽçŽ åéå å€ãšããŠ
ã¯ãäŸãã°æ°ŽçŽ åç¡ŒçŽ ãããªãŠã ãæ°ŽçŽ åã¢ã«ã
ããŠã ãªããŠã ããžãã©ã³ãªã©ãæãããããã®
䜿çšéã¯ãéåžžãååç©13ãŸãã¯15ã«å¯ŸããŠå°ãª
ããšãçã¢ã«çšåºŠã奜ãŸããã¯çã¢ã«ãïŒåã¢ã«
ã®ç¯å²ã§ãããæ°ŽçŽ åéå å€ãšããŠæ°ŽçŽ åã¢ã«ã
ããŠã ãªããŠã ãçšããå Žåã«ã¯ååç©13ãŸãã¯
15ãšçééçšããã®ã奜éœåã§ããããã®éå å
å¿ã¯ãéåžžãé©åœãªæº¶åªãäŸãã°æ°Žãã¡ã¿ããŒ
ã«ããšã¿ããŒã«ãã€ãœãããããŒã«ãªã©ã®äœçŽã¢
ã«ã³ãŒã«é¡ãããã©ããããã©ã³ããšãã«ãšãŒã
ã«ããžã°ã©ã€ã ãªã©ã®ãšãŒãã«é¡ãªã©ãçšããçŽ
â60ã50âã奜ãŸããã¯â30ã宀枩ã«ãŠãçŽ10å
éãïŒæéçšåºŠã§è¡ãªãããããªããéå å€ãšã
ãŠæ°ŽçŽ åã¢ã«ãããŠã ãªããŠã ããžãã©ã³ãçšã
ãå Žåã«ã¯ãšãã«ãšãŒãã«ãããã©ããããã©
ã³ããžã°ã©ã€ã ãªã©ã®ç¡æ°Žã®æº¶åªãçšããã®ãã
ãã ååç©ïŒïŒãããã²ã³åããŠååç©ïŒã«å°ãå
å¿ã¯ãéåžžã®æ°Žé žåºã®ããã²ã³ååå¿ã«ãããå
å¿æ¡ä»¶ãããããæ¡çšãããäŸãã°ãé©åœãªäžæŽ»
æ§æº¶åªäžãŸãã¯ç¡æº¶åªã«ãŠååç©ïŒïŒã«ããã²ã³
åå€ãåå¿ãããŠè¡ãªããçšããããããã²ã³å
å€ãšããŠã¯ãäŸãã°å¡©é žãèåæ°ŽçŽ é žãªã©ã®ãã
ã²ã³åæ°ŽçŽ é žãïŒïŒ®âãžãšãã«âïŒïŒïŒïŒïŒâ
ããªã¯ãã«ããã«ã¢ãããäºå¡©åãªã³ãäºèåãª
ã³ããªãã·å¡©åãªã³ãããªãã«ã¯ããªããªã©ãæ
ãããããäžæŽ»æ§æº¶åªãšããŠã¯ãäŸãã°ãžãªããµ
ã³ãããã©ããããã©ã³ãªã©ã®ãšãŒãã«é¡ãã¯ã
ããã«ã ãå¡©åã¡ãã¬ã³ãåå¡©åççŽ ãªã©ã®ãã
ã²ã³åçåæ°ŽçŽ é¡ãªã©ãæãããããååç©ïŒïŒ
ãšããã²ã³åå€ãšã®äœ¿çšå²åã¯ãåè ã«å¯ŸããŠåŸ
è ãå°ãªããšãçã¢ã«ãéåžžã¯éå°éã§ããã該
åå¿ã¯ãéåžžã宀枩ã150âçšåºŠã奜ãŸããã¯å®€
æž©80âã«ãŠãïŒãïŒæéçšåºŠè¡ãªãããã åèšåå¿åŒâXIã«ãããåºçºç©è³ªã®ã«ã«ãã³é ž
ååç©13ããã³ãã®ãšã¹ãã«ååç©15ãäžéšå ¬ç¥
ã§æ°èŠååç©ãå«ã¿ãäŸãã°äžèšåå¿åŒâXIIã
ã§ç€ºãããæ¹æ³ã«ãã補é ã§ããã K0031 ãåŒäžãR2ã¯åèšã«åããR11ã¯æ°ŽçŽ ååãŸã
ã¯äœçŽã¢ã«ãã«ã瀺ãã äžèšåå¿åŒã«ãããŠãååç©17ã®ãããåºã®é
å åå¿ã¯éåžžã®ãããåºã®éå åå¿æ¡ä»¶ãããã
ãæ¡çšãããäŸãã°(i)é©åœãªæº¶åªäžæ¥è§Šéå 觊åª
ãçšããŠéå ãããã(ii)é©åœãªäžæŽ»æ§æº¶åªäžãé
å±ãŸãã¯éå±å¡©ãšé žããããã¯éå±ãŸãã¯éå±å¡©
ãšã¢ã«ã«ãªéå±æ°Žé žåç©ãç¡«åç©ãŸãã¯ã¢ã³ã¢ã
ãŠã å¡©ãªã©ãšã®æ··åç©ãéå å€ãšããŠçšããŠéå
ããããšã«ããè¡ãªãããã (i)ã®æ¥è§Šéå ã«ããå Žåãçšãããã溶åªãšã
ãŠã¯ãäŸãã°æ°Žãé ¢é žãã¡ã¿ããŒã«ããšã¿ããŒ
ã«ãã€ãœãããããŒã«ããã¿ããŒã«ããšãã¬ã³ã°
ãªã³ãŒã«ãªã©ã®ã¢ã«ã³ãŒã«é¡ããžãšãã«ãšãŒã
ã«ããžã¡ãã«ãšãŒãã«ãããã©ããããã©ã³ããž
ãªããµã³ãã¢ãã°ã©ã€ã ããžã°ã©ã€ã ãªã©ã®ãšãŒ
ãã«é¡ããããµã³ãã·ã¯ããããµã³ãªã©ã®çåæ°Ž
çŽ é¡ãé ¢é žã¡ãã«ãé ¢é žãšãã«ãªã©ã®ãšã¹ãã«
é¡ãïŒïŒ®âãžã¡ãã«ãã«ã ã¢ãããªã©ã®éãã
ãã³æ§æ¥µæ§æº¶åªãªã©ãæãããããæ¥è§Šéå 觊åª
ãšããŠã¯ãäŸãã°ãã©ãžãŠã ããã©ãžãŠã é»ãã
ã©ãžãŠã ççŽ ãçœéãé žåçœéãäºã¯ãã é žé ã
ã©ããŒããã±ã«ãªã©ãæãããããããã觊åªã®
䜿çšéã¯ãååç©17ã«å¯ŸããŠ0.02ã1.00åïŒé
éïŒçšããã®ããããåå¿ã¯éåžžâ20ã150âã
奜ãŸããã¯ïŒâã宀枩ä»è¿ãæ°ŽçŽ å§ïŒã10æ°å§ã§
30åã10æéçšåºŠè¡ãªãããã (ii)ã®æ¹æ³ãçšããå Žåã«ã¯ãéå å€ãšããŠéã
äºéãé«ãŸãã¯å¡©å第äžé«ãšå¡©é žãç¡«é žãªã©ã®é±
é žãšã®çµåããéãç¡«é žç¬¬äžéãäºéãŸãã¯é«ãš
æ°Žé žåãããªãŠã ãªã©ã®ã¢ã«ã«ãªéå±æ°Žé žåç©ã
ç¡«åã¢ã³ã¢ããŠã ãªã©ã®ç¡«åç©ãã¢ã³ã¢ãã¢æ°Žã
å¡©åã¢ã³ã¢ããŠã ãªã©ã®ã¢ã³ã¢ããŠã å¡©ãªã©ãšã®
çµåããçšããããã䜿çšãããäžæŽ»æ§æº¶åªãšã
ãŠã¯ãäŸãã°æ°Žãé ¢é žãã¡ã¿ããŒã«ããšã¿ããŒ
ã«ããžãªããµã³ãªã©ãæãããããåå¿æž©åºŠãæ
éã¯çšãããã觊åªã®çš®é¡ã«ããé©å®éžæããã
äŸãã°ç¡«é žç¬¬äžéãšã¢ã³ã¢ãã¢æ°Žãšã®çµåãã®å Ž
åã«ã¯50ã150âä»è¿ã§30åã10æéçšåºŠã§æå©
ã«è¡ãªããããéå å€ã®äœ¿çšéã¯ãéåžžãååç©
17ã«å¯ŸããŠå°ãªããšãçã¢ã«ã奜ãŸããã¯çã¢ã«
ãïŒåã¢ã«ã§ããã ååç©18ãšååç©19ãšã®åå¿ã¯ãå¡©åºæ§ååç©
ã®ååšäžãé©åœãªæº¶åªäžã§è¡ãªãããšãã§ããã
å¡©åºæ§ååç©ãšããŠã¯äŸãã°æ°Žé žåãããªãŠã ã
çé žã«ãªãŠã ãçé žæ°ŽçŽ ãããªãŠã ãçé žæ°ŽçŽ ã«
ãªãŠã ãæ°ŽçŽ åãããªãŠã ããããªãŠã ã¡ãã©ãŒ
ãããããªãŠã ãšãã©ãŒããªã©ã®ç¡æ©å¡©åºãããª
ãšãã«ã¢ãã³ãããªãžã³ãαâãã³ãªã³ãïŒïŒ®
âãžã¡ãã«ã¢ããªã³ãâã¡ãã«ã¢ã«ããªã³ãã
ããªãžã³ããããªãžã³ãªã©ã®ã¢ãã³é¡ãªã©åºç¯å²
ã®ãã®ãçšããããã溶åªãšããŠã¯ãžãªããµã³ã
ããã©ããããã©ã³ãã°ã©ã€ã ããžã°ã©ã€ã ãªã©
ã®ãšãŒãã«é¡ããã«ãšã³ããã·ã¬ã³ãªã©ã®è³éŠæ
çåæ°ŽçŽ é¡ãã¡ã¿ããŒã«ããšã¿ããŒã«ãã€ãœãã
ãããŒã«ãªã©ã®äœçŽã¢ã«ã³ãŒã«é¡ããžã¡ãã«ãã«
ã ã¢ããããžã¡ãã«ã¹ã«ããã·ããªã©ã®æ¥µæ§æº¶åª
ãæãããããåå¿ã¯å®€æž©ã150âã奜ãŸããã¯
60ã120âã«ãŠïŒã24æéçšåºŠè¡ãªããããåå
ç©18ãšååç©19ã®äœ¿çšå²åã¯ç¹ã«å¶éãããªã
ããéåžžåè ã«å¯ŸããŠåŸè ãçã¢ã«ãéå°éã奜
ãŸããã¯çã¢ã«ãïŒåã¢ã«çšããã K0032 ãåŒäžãR2ã¯åèšã«åããã¯äœçŽã¢ã«ãã«
ã瀺ãã äžèšã®åå¿ã¯ãååç©20ãRCOXãŸãã¯
ïŒRCOïŒ2OãåŒäžïŒ²ã¯åèšã«åããã¯ããã²ã³å
åã瀺ãããšåå¿ãããŠãååç©20aã«ããã€ã¥
ããŠå æ°Žå解ããããšã«ããååç©13bãåŸãã
ãšãã§ãããäžè¬åŒïŒ20ïŒãšRCOXãŸãã¯
ïŒRCOïŒ2Oãšã®åå¿ã¯å¡©åºæ§ååç©ã®ååšäžãŸã
ã¯éååšäžã«è¡ãªãããã䜿çšãããå¡©åºæ§åå
ç©ãšããŠã¯äŸãã°éå±ãããªãŠã ãéå±ã«ãªãŠã
ãªã©ã®ã¢ã«ã«ãªéå±ããã³ãããã¢ã«ã«ãªéå±ã®
æ°Žé žåç©ãçé žå¡©ãéçé žå¡©ãããã¯ããªãžã³ã
ãããªãžã³ãªã©ã®è³éŠæã¢ãã³ååç©ãªã©ãæã
ãããã該åå¿ã¯ç¡æº¶åªãããã¯æº¶åªäžã®ããã
ã§ãé²è¡ããã溶åªãšããŠã¯ãäŸãã°ã¢ã»ãã³ã
ã¡ãã«ãšãã«ã±ãã³ãªã©ã®ã±ãã³é¡ããšãŒãã«ã
ãžãªããµã³ãªã©ã®ãšãŒãã«é¡ããã³ãŒã³ããã«ãš
ã³ããã·ã¬ã³ãªã©ã®è³éŠæçåæ°ŽçŽ é¡ãæ°Žãããª
ãžã³ãªã©ãæãããããRCOXãŸãã¯ïŒRCO2ïŒ
ã®ååç©ã®äœ¿çšéã¯ãäžè¬åŒïŒ20ïŒã®ååç©ã«
察ããŠãå°ããšãçã¢ã«çšããããããäžè¬ã«
ã¯ãçã¢ã«ã倧éå°éçšããã®ãããããŸã該å
å¿ã¯ãïŒã200âã§é²è¡ããããäžè¬ã«ã¯ïŒã150
âã§è¡ãªãã®ããããåå¿æéã¯ã0.5ã10æé
çšåºŠã§çµäºããã äžè¬åŒïŒ20aïŒã®å æ°Žå解åå¿ã¯ã氎溶液äžå
æ°Žå解觊åªãäŸãã°æ°Žé žåã«ãªãŠã ãæ°Žé žåãã
ãªãŠã ãªã©ã®ã¢ã«ã«ãªéå±æ°Žé žåç©ãçé žãããª
ãŠã ãçé žã«ãªãŠã ãçé žæ°ŽçŽ ãããªãŠã ãªã©ã®
ç¡æ©ã¢ã«ã«ãªååç©ã®ååšäžã«ãéåžž50ã150âã
奜ãŸããã¯70ã100âã«ãŠ0.5ã10æéçšåºŠå ç±ã
ãŠè¡ãªãããã K0033 ãåŒäžãR1ïŒR2ïŒR10ïŒïŒžïŒïŒ¡ïŒïœããã³ã«ã«
ãã¹ããªã«éªšæ žã®ïŒäœãšïŒäœéã®çµåã¯åèšã«å
ããR12ã¯è³éŠæã¢ãã³æ®åºã瀺ãã äžèšåå¿åŒã«ãããŠãååç©21ãšè³éŠæã¢ãã³
22ãšã®åå¿ã¯ãé©åœãªæº¶åªäžãŸãã¯ç¡æº¶åªäžã«è¡
ãªãããã溶åªãšããŠã¯åå¿ã«æªåœ±é¿ãäžããªã
äžæŽ»æ§ã®ãã®ããã¹ãŠçšããããäŸãã°ã¯ããã
ã«ã ãå¡©åã¡ãã¬ã³ããžã¯ããã¡ã¿ã³ãåå¡©åç
çŽ ãªã©ã®ããã²ã³åçåæ°ŽçŽ é¡ããžãšãã«ãšãŒã
ã«ãããã©ããããã©ã³ããžãªããµã³ããžã¡ãã
ã·ãšã¿ã³ãªã©ã®ãšãŒãã«é¡ãã¡ã¿ããŒã«ããšã¿ã
ãŒã«ãã€ãœãããããŒã«ããã¿ããŒã«ãªã©ã®ã¢ã«
ã³ãŒã«é¡ãé ¢é žã¡ãã«ãé ¢é žãšãã«ãªã©ã®ãšã¹ã
ã«é¡ãNNâãžã¡ãã«ãã«ã ã¢ããããžã¡ãã«ã¹
ã«ãããµã€ãããããµã¡ãã«ãªã³é žããªã¢ãããª
ã©ã®éãããã³æ§æ¥µæ§æº¶åªãã¢ã»ããããªã«ãªã©
ãæãããããè³éŠæã¢ãã³ãšããŠã¯ãããªãž
ã³ããããªã³ãªã©ãäŸç€ºã§ããã該è³éŠæã¢ãã³
ã®äœ¿çšéã¯ãååç©21ã«å¯ŸããŠå°ãªããšãçã¢
ã«ã奜ãŸããã¯å€§éå°éã§çšãããåå¿æž©åºŠã¯50
ã200âã奜ãŸããã¯70ã150âã§ãããïŒã10æ
éçšåºŠã§åå¿ã¯çµäºããã ããããååç©23ã®å æ°Žå解ã¯ãæ°Žäžãæ°Žé žå
ãããªãŠã ãæ°Žé žåã«ãªãŠã ã®ãããªç¡æ©å¡©åºã®
ååšäžã«å®€æž©ã150âã«ãŠïŒã10æéçšåºŠåŠçã
ãŠè¡ãªãããã ãŸãååç©23ã®ååç©14ã«ãããšã¹ãã«åã¯å¡©
åºæ§ååç©ã®ååšäžã溶åªäžãŸãã¯ç¡æº¶åªã«ãŠå
å¿ãããããšã«ããè¡ãªãããã䜿çšããã溶åª
ãšããŠã¯ãäŸãã°å¡©åã¡ãã¬ã³ãã¯ãããã«ã ã
ãžã¯ãããšã¿ã³ãªã©ã®ããã²ã³åçåæ°ŽçŽ é¡ãã
ã³ãŒã³ããã«ãšã³ããã·ã¬ã³ãªã©ã®è³éŠæçåæ°Ž
çŽ é¡ããžãšãã«ãšãŒãã«ãããã©ããããã©ã³ã
ãžãªããµã³ããžã¡ããã·ãšã¿ã³ãªã©ã®ãšãŒãã«
é¡ãïŒïŒ®âãžã¡ãã«ãã«ã ã¢ããããžã¡ãã«ã¹
ã«ããã·ãããããµã¡ãã«ãªã³é žããªã¢ãããªã©
ã®éãããã³æ§æº¶åªãªã©ãäŸç€ºã§ããã䜿çšãã
ãå¡©åºæ§è§ŠåªãšããŠã¯ãäŸãã°ããªãšãã«ã¢ã
ã³ãããªã¡ãã«ã¢ãã³ãããªãžã³ããžã¡ãã«ã¢ã
ãªã³ãâã¡ãã«ã¢ã«ããªã³ãïŒâãžã¡ãã«ã¢ã
ãããªãžã³ãïŒïŒïŒâãžã¢ã¶ãã·ã¯ãã4.3.0ã
ããã³âïŒïŒDBNïŒãïŒïŒïŒâãžã¢ã¶ãã·ã¯ã
ã5.4.0ããŠã³ãã»ã³âïŒïŒDBUïŒãïŒïŒïŒâãžã¢ã¶
ãã·ã¯ãã2.2.2ããªã¯ã¿ã³ïŒDABCOïŒãªã©ã®æ
æ©å¡©åºããã³çé žã«ãªãŠã ãçé žãããªãŠã ãç
é žæ°ŽçŽ ã«ãªãŠã ãçé žæ°ŽçŽ ãããªãŠã ãªã©ã®ç¡æ©
å¡©åºãªã©ãäŸç€ºã§ãããããã§äœ¿çšãããå¡©åºæ§
ååç©ã®äœ¿çšå²åãšããŠã¯ãäžè¬åŒïŒ23ïŒã®åå
ç©ã«å¯ŸããŠãå°ããšãçã¢ã«ã奜ãŸããã¯ïŒã
1.5åã¢ã«é䜿çšããã®ããããäžè¬åŒïŒ14ïŒã®
ååç©ã®äœ¿çšå²åã¯ãäžè¬åŒïŒ23ïŒã®ååç©ã«å¯Ÿ
ããŠãå°ãªããšãçã¢ã«ãé垞倧éå°éã§äœ¿çšã
ãã®ããããåå¿æž©åºŠã¯ãé垞宀枩ã150âã奜
ãŸããã¯50ã100âä»è¿ã§ããã該åå¿ã¯äžè¬ã«
30åã10æéã§çµäºããã K0034 K0035 K0036 ãåŒäžãR11ããã³ïŒžã¯åèšã«åããXâ²ã¯æ°ŽçŽ
ååãŸãã¯ããã²ã³ååã瀺ãã äžèšåå¿åŒã«ãããŠãååç©24ãšååç©25ãŸã
ã¯26ãšã®åå¿ã¯äžè¬ã«ããªãŒãã«ã¯ã©ããåå¿ãš
åŒã°ãããã®ã§ãããéåžžãé©åœãªæº¶åªäžãã«ã€
ã¹é žã®ååšäžã«è¡ãªããããçšãããã溶åªãšã
ãŠã¯ãã®çš®ã®åå¿ã«é垞䜿çšããããã®ãæå©ã«
çšããããäŸãã°äºç¡«åççŽ ãããããã³ãŒã³ã
ã¯ãããã³ãŒã³ããžã¯ããã¡ã¿ã³ããžã¯ãããšã¿
ã³ãããªã¯ãããšã¿ã³ãåå¡©åççŽ ãªã©ãæãã
ãããã«ã€ã¹é žãšããŠãéåžžçšãããããã®ãã
ã¹ãŠäœ¿çšãããäŸãã°å¡©åã¢ã«ãããŠã ãå¡©åäº
éãå¡©åéãå¡©åé«ãäžèåããŠçŽ ãäžããåã
ãŠçŽ ãæ¿ç¡«é žãªã©ãæãããããã«ã€ã¹é žã®äœ¿çš
éã¯é©å®æ±ºå®ããããããéåžžãååç©24ã«å¯Ÿã
ãŠïŒãïŒåã¢ã«çšåºŠã奜ãŸããã¯ïŒãïŒåã¢ã«ã§
ãããååç©25ãŸãã¯26ã®äœ¿çšéã¯ååç©24ã«å¯Ÿ
ããŠãéåžžãå°ãªããšãçã¢ã«ã奜ãŸããã¯çã¢
ã«ãïŒåã¢ã«ã§ãããåå¿æž©åºŠã¯éåžžâ50ã120
âçšåºŠã奜ãŸããã¯ïŒã70âã§ããããŸãåå¿æ
éã¯çšããåæã觊åªãåå¿æž©åºŠãªã©ã«ãã€ãŠã
ç°ãªãããéåžžã30åã24æéçšåºŠã§ããã ããããååç©27ã®ãããåã¯ãéåžžã®è³éŠæ
ååç©ã®ãããååå¿ãšåæ§ã®æ¡ä»¶äžã«è¡ãªã
ããäŸãã°é©åœãªäžæŽ»æ§æº¶åªäžãŸãã¯ç¡æº¶åªäžã«
ãããåå€ãäœçšãããŠè¡ãªããäžæŽ»æ§æº¶åªãšã
ãŠã¯ãäŸãã°é ¢é žãç¡æ°Žé ¢é žãæ¿ç¡«é žãªã©ãæã
ããããŸããããåå€ãšããŠã¯ãäŸãã°çºç ç¡
é žãæ¿ç¡é žãç¡é žãšä»ã®é žïŒç¡«é žãçºç ç¡«é žããª
ã³é žãç¡æ°Žé ¢é žïŒãšã®æ··é žãç¡é žã«ãªãŠã ãç¡é ž
ãããªãŠã ãªã©ã®ã¢ã«ã«ãªéå±ç¡é žå¡©ãšç¡«é žãªã©
ã®é±é žãšã®æ··åç©ãªã©ãæããããã該ãããå
å€ã®äœ¿çšéã¯ååç©27ã«å¯ŸããŠçã¢ã«ä»¥äžãéåžž
éå°éã§ãããåå¿æž©åºŠã¯â10âã宀枩ä»è¿ã奜
ãŸãããïŒåãïŒæéåå¿ãããã ããããååç©28ã¯éå ãéç°ã«ããååç©
13eã«å°ãããããã®åå¿ã¯åèšåå¿åŒâXIã«ã
ããååç©17ã®éå åå¿æ¡ä»¶ãšåæ§ã®æ¡ä»¶äžã«è¡
ãªããããã(i)ã®æ¥è§Šéå æ¹æ³ãçšããå Žåã¯ã
åå¿æž©åºŠã¯ã奜ãŸããã¯ïŒã50âã§ããããŸãå
å¿ç³»å ã«æ°Žé žåãããªãŠã ãæ°Žé žåã«ãªãŠã ãªã©
ã®å¡©åºæ§ååç©ãååšãããããšã«ããåå¿ãæ
å©ã«é²è¡ãããããã«(ii)ã®æ¹æ³ãçšããå Žåã«
ã¯ãéåžžâ50ã100âã«ãããŠåå¿ã¯é²è¡ãã0.5
ã10æéçšåºŠã§åå¿ã¯çµäºãããäŸãã°ãå¡©å第
ïŒé«ãšå¡©é žãšãéå å€ãšããŠçšããå Žåãæå©ã«
ã¯â20ã50âä»è¿ã«ãŠåå¿ãè¡ãªãã®ããããé
å å€ã®äœ¿çšéãšããŠã¯ãåæååç©ã«å¯ŸããŠå°ã
ãšãçã¢ã«éãéåžžã¯çã¢ã«ãïŒåã¢ã«éçšãã
ã®ããããäžèšã®æ¹æ³ã«ãããããåºã®éå ãšå
æã«éç°ããŠååç©13eãããããããã ãã(i)
ã®æ¥è§Šéå 觊åªãçšããå Žåã«ã¯ã«ã«ããã«åºã
éå ãããŠã¡ãã¬ã³ã«å€æãããå Žåããããã
åå¿æ¡ä»¶ãé©åœã«éžæããããšã«ãããã®ãããª
å€æã¯é¿ããããã K0037 K0038 ãåŒäžãR2ïŒR11ããã³ïŒžã¯åèšã«åããR13
ã¯äœçŽã¢ã«ãã«ã瀺ãã äžèšåå¿åŒã«ãããŠååç©29ãšååç©30ãšã®å
å¿ã¯ãéåžžãè±ããã²ã³åæ°ŽçŽ å€ã®ååšäžãŸãã¯
äžååšäžã«é©åœãªæº¶åªäžã§è¡ãªããããè±ããã²
ã³åæ°ŽçŽ å€ãšããŠã¯éåžžå¡©åºæ§ååç©ãçšãã
ããäŸãã°ãããªãšãã«ã¢ãã³ãããªã¡ãã«ã¢ã
ã³ãããªãžã³ããžã¡ãã«ã¢ããªã³ãâã¡ãã«ã¢
ã«ããªã³ãïŒâãžã¡ãã«ã¢ããããªãžã³ãïŒïŒïŒ
âãžã¢ã¶ãã·ã¯ãã4.3.0ãããã³âïŒïŒDBNïŒã
ïŒïŒïŒâãžã¢ã¶ãã·ã¯ãã5.4.0ããŠã³ãã»ã³â
ïŒïŒDBUïŒãïŒïŒïŒâãžã¢ã¶ãã·ã¯ãã2.2.2ããª
ã¯ã¿ã³ïŒDABCOïŒãªã©ã®ææ©å¡©åºãçé žã«ãªãŠ
ã ãçé žãããªãŠã ãçé žæ°ŽçŽ ã«ãªãŠã ãçé žæ°Ž
çŽ ãããªãŠã ãæ°Žé žåãããªãŠã ãæ°Žé žåã«ãªãŠ
ã ãæ°ŽçŽ åãããªãŠã ãæ°ŽçŽ åã«ãªãŠã ãçé ž
éããããªãŠã ã¡ãã©ãŒãããããªãŠã ãšãã©ãŒ
ããªã©ã®ã¢ã«ã«ãªéå±ã¢ã«ã³ã©ãŒããªã©ãæãã
ããããªãåå¿ååç©ã®ååç©30ãéå°éçšããŠ
è±ããã²ã³åæ°ŽçŽ å€ãšããŠå Œçšãããããšãã§ã
ãã溶åªãšããŠã¯å¡©åã¡ãã¬ã³ãã¯ãããã«ã ã
ãžã¯ãã«ãšã¿ã³ãªã©ã®ããã²ã³åççŽ é¡ããã³ãŒ
ã³ããã«ãšã³ããã·ã¬ã³ãªã©ã®è³éŠæçåæ°ŽçŽ
é¡ããžãšãã«ãšãŒãã«ãããã©ããããã©ã³ããž
ã¡ããã·ãšã¿ã³ãªã©ã®ãšãŒãã«é¡ãé ¢é žã¡ãã«ã
é ¢é žãšãã«ãªã©ã®ãšã¹ãã«é¡ããžã¡ãã«ãã«ã ã¢
ããããžã¡ãã«ã¹ã«ããã·ãããããµã¡ãã«ãªã³
é žããªã¢ãããªã©ã®éãããã³æ§æ¥µæ§æº¶åªãããª
ãžã³ãã¢ã»ãã³ãã¢ã»ããããªã«ãããã«ã¡ã¿ã
ãŒã«ããšã¿ããŒã«ããããããŒã«ããã¿ããŒã«ã
ïŒâã¡ããã·âïŒâãã¿ããŒã«ããšãã«ã»ããœã«
ããã¡ãã«ã»ããœã«ããªã©ã®ã¢ã«ã³ãŒã«é¡ãããª
ãžã³ãã¢ã»ãã³ãã¢ã»ããããªã«ãªã©ããŸãã¯ã
ããã®ïŒçš®ä»¥äžã®æ··å溶åªãæãããããååç©
29ãšååç©30ãšã®äœ¿çšå²åã¯ç¹ã«éå®ãããåºç¯
å²ã«éžæãããããéåžžåè ã«å¯ŸããŠåŸè ãå°ãª
ããšãçã¢ã«ã奜ãŸããã¯çã¢ã«ãïŒåã¢ã«çšã
ããããåå¿æž©åºŠã¯éåžžâ30ã180âçšåºŠã奜ãŸ
ããã¯çŽïŒã150âã§ãäžè¬ã«ïŒåã30æéã§å
å¿ã¯å®çµããã ååç©31ã®éç°åå¿ã¯ãé©åœãªæº¶åªäžãŸãã¯ç¡
溶åªäžã«é žã®ååšäžã«è¡ãªããããé žãšããŠã¯ç¹
ã«éå®ãããéåžžã®ææ©é žãŸãã¯ãç¡æ©é žãçšã
ãããäŸãã°å¡©é žãèåæ°ŽçŽ é žãç¡«é žãªã©ã®ç¡æ©
é žãå¡©åã¢ã«ãããŠã ãäžããåããŠçŽ ãåå¡©å
ãã¿ã³ãªã©ã®ã«ã€ã¹é žãã®é žãé ¢é žããšã¿ã³ã¹ã«
ãã³é žãïœâãã«ãšã³ã¹ã«ãã³é žãªã©ã®ææ©é žã
æããããããããã®ãã¡ãå¡©é žãèåæ°ŽçŽ é žã
ç¡«é žãªã©ã®ç¡æ©é žã奜ãŸãããé žã®äœ¿çšéã¯ç¹ã«
éå®ããããéåžžãååç©31ã«å¯ŸããŠå°ãªããšã
çééã奜ãŸããã¯10ã50åééã§ããããŸã溶
åªãšããŠã¯éåžžã®äžæŽ»æ§æº¶åªãçšããããäŸãã°
æ°Žãã¡ã¿ããŒã«ããšã¿ããŒã«ããããããŒã«ãªã©
ã®äœçŽã¢ã«ã³ãŒã«é¡ããžãªããµã³ãããã©ããã
ãã©ã³ãªã©ã®ãšãŒãã«é¡ããã³ãŒã³ããã«ãšã³ã
ãã·ã¬ã³ãªã©ã®è³éŠæçåæ°ŽçŽ é¡ãå¡©åã¡ãã¬
ã³ãã¯ãããã«ã ãåå¡©åççŽ ãªã©ã®ããã²ã³å
çåæ°ŽçŽ é¡ãã¢ã»ãã³ããžã¡ãã«ã¹ã«ããã·ãã
ãžã¡ãã«ãã«ã ã¢ããããããµã¡ãã«ãªã³é žããª
ã¢ãããªã©ã®éãããã³æ§æ¥µæ§æº¶åªãªã©ãæãã
ããããããã®ãã¡ãäœçŽã¢ã«ã³ãŒã«é¡ããšãŒã
ã«é¡ãã¢ã»ãã³ããžã¡ãã«ã¹ã«ããã·ãããžã¡ã
ã«ãã«ã ã¢ããããããµã¡ãã«ãªã³é žããªã¢ãã
ãªã©ã®æ°Žæº¶æ§æº¶åªã奜ãŸããã該åå¿ã¯éåžžïŒã
100âã奜ãŸããã¯å®€æž©ã60âã§è¡ãªãããéåžž
ïŒåãïŒæéçšåºŠã§çµäºããã ãªãã該ååç©13ã13fããã³15ã¯ãåèšåå¿
åŒâããã³ã«ç€ºãããâã¢ã«ãã«åæ¹æ³ãª
ãã³ã«åå¿åŒâããã³ã«ç€ºãããè±æ°ŽçŽ åå¿
ãŸãã¯éå åå¿ãå©çšããæ¹æ³ãªã©ã«ãããåæ§
ã«å¯Ÿå¿ããä»ã®åŒïŒ13ïŒãïŒ13fïŒããã³ïŒ15ïŒ
ã®ååç©ã«å°ãããšãã§ããã ããã«ãåèšåå¿åŒâXIã«ãããäžéäœã§ãã
ååç©ïŒïŒããã³ååç©ïŒãªãã³ã«åèšåå¿åŒâ
ã«ãããåºçºç©è³ªã§ããååç©21ãªã©ã¯äžèš
åå¿åŒâãXIã«ç€ºãããæ¹æ³ã«ãã€ãŠã補
é ãããã K0039 ãåŒäžãR1ïŒïŒžïŒXâ²ããã³ã«ã«ãã¹ããªã«éªš
æ žã®ïŒäœãšïŒäœéã®çµåã¯åèšãšåãã äžèšã®ååç©32ãšååç©25ãŸãã¯26ãšã®åå¿
ã¯ãåèšåå¿åŒâã«ãããååç©24ãšååç©
25ãŸãã¯26ãšã®åå¿ãšåæ§ã®æ¡ä»¶äžã«è¡ãªãã
ãããã ããåå¿æž©åºŠã¯éåžž20ã120âã奜ãŸã
ãã¯40ã70âçšåºŠã§ãåå¿æéã¯åæã觊åªãå
å¿æž©åºŠã«ããç°ãªãããéåžž30åã24æéçšåºŠã§
ããã K0040 ãåŒäžãR1ïŒR2ïŒïŒ¡ïŒïœããã³ã«ã«ãã¹ããª
ã«éªšæ žã®ïŒäœãšïŒäœéã®çµåã¯åèšã«åããR14
ã¯æ°ŽçŽ ååãäœçŽã¢ã«ãã«ãŸãã¯åº
ãšã®åå¿ã¯ãåèšåå¿åŒâã«ãããååç©1a
ãŸãã¯1bã®ååç©ïŒã«ãããšã¹ãã«ååå¿ãšå š
ãåæ§ã®åå¿æ¡ä»¶äžã«è¡ãªãããšãã§ããã 該ãšã¹ãã«åã«ããããããååç©15ãéå ã
ãŠå¯Ÿå¿ããååç©ïŒïŒã«å°ãããšãã§ããããªã
ãã®ååç©ïŒïŒã¯ååç©13ãçŽæ¥éå ããŠããã
ããããããã®éå åå¿ã¯ãéåžžãæ°ŽçŽ åéå å€
ãçšããŠè¡ãªãããããã®æ°ŽçŽ åéå å€ãšããŠ
ã¯ãäŸãã°æ°ŽçŽ åç¡ŒçŽ ãããªãŠã ãæ°ŽçŽ åã¢ã«ã
ããŠã ãªããŠã ããžãã©ã³ãªã©ãæãããããã®
䜿çšéã¯ãéåžžãååç©13ãŸãã¯15ã«å¯ŸããŠå°ãª
ããšãçã¢ã«çšåºŠã奜ãŸããã¯çã¢ã«ãïŒåã¢ã«
ã®ç¯å²ã§ãããæ°ŽçŽ åéå å€ãšããŠæ°ŽçŽ åã¢ã«ã
ããŠã ãªããŠã ãçšããå Žåã«ã¯ååç©13ãŸãã¯
15ãšçééçšããã®ã奜éœåã§ããããã®éå å
å¿ã¯ãéåžžãé©åœãªæº¶åªãäŸãã°æ°Žãã¡ã¿ããŒ
ã«ããšã¿ããŒã«ãã€ãœãããããŒã«ãªã©ã®äœçŽã¢
ã«ã³ãŒã«é¡ãããã©ããããã©ã³ããšãã«ãšãŒã
ã«ããžã°ã©ã€ã ãªã©ã®ãšãŒãã«é¡ãªã©ãçšããçŽ
â60ã50âã奜ãŸããã¯â30ã宀枩ã«ãŠãçŽ10å
éãïŒæéçšåºŠã§è¡ãªãããããªããéå å€ãšã
ãŠæ°ŽçŽ åã¢ã«ãããŠã ãªããŠã ããžãã©ã³ãçšã
ãå Žåã«ã¯ãšãã«ãšãŒãã«ãããã©ããããã©
ã³ããžã°ã©ã€ã ãªã©ã®ç¡æ°Žã®æº¶åªãçšããã®ãã
ãã ååç©ïŒïŒãããã²ã³åããŠååç©ïŒã«å°ãå
å¿ã¯ãéåžžã®æ°Žé žåºã®ããã²ã³ååå¿ã«ãããå
å¿æ¡ä»¶ãããããæ¡çšãããäŸãã°ãé©åœãªäžæŽ»
æ§æº¶åªäžãŸãã¯ç¡æº¶åªã«ãŠååç©ïŒïŒã«ããã²ã³
åå€ãåå¿ãããŠè¡ãªããçšããããããã²ã³å
å€ãšããŠã¯ãäŸãã°å¡©é žãèåæ°ŽçŽ é žãªã©ã®ãã
ã²ã³åæ°ŽçŽ é žãïŒïŒ®âãžãšãã«âïŒïŒïŒïŒïŒâ
ããªã¯ãã«ããã«ã¢ãããäºå¡©åãªã³ãäºèåãª
ã³ããªãã·å¡©åãªã³ãããªãã«ã¯ããªããªã©ãæ
ãããããäžæŽ»æ§æº¶åªãšããŠã¯ãäŸãã°ãžãªããµ
ã³ãããã©ããããã©ã³ãªã©ã®ãšãŒãã«é¡ãã¯ã
ããã«ã ãå¡©åã¡ãã¬ã³ãåå¡©åççŽ ãªã©ã®ãã
ã²ã³åçåæ°ŽçŽ é¡ãªã©ãæãããããååç©ïŒïŒ
ãšããã²ã³åå€ãšã®äœ¿çšå²åã¯ãåè ã«å¯ŸããŠåŸ
è ãå°ãªããšãçã¢ã«ãéåžžã¯éå°éã§ããã該
åå¿ã¯ãéåžžã宀枩ã150âçšåºŠã奜ãŸããã¯å®€
æž©80âã«ãŠãïŒãïŒæéçšåºŠè¡ãªãããã åèšåå¿åŒâXIã«ãããåºçºç©è³ªã®ã«ã«ãã³é ž
ååç©13ããã³ãã®ãšã¹ãã«ååç©15ãäžéšå ¬ç¥
ã§æ°èŠååç©ãå«ã¿ãäŸãã°äžèšåå¿åŒâXIIã
ã§ç€ºãããæ¹æ³ã«ãã補é ã§ããã K0031 ãåŒäžãR2ã¯åèšã«åããR11ã¯æ°ŽçŽ ååãŸã
ã¯äœçŽã¢ã«ãã«ã瀺ãã äžèšåå¿åŒã«ãããŠãååç©17ã®ãããåºã®é
å åå¿ã¯éåžžã®ãããåºã®éå åå¿æ¡ä»¶ãããã
ãæ¡çšãããäŸãã°(i)é©åœãªæº¶åªäžæ¥è§Šéå 觊åª
ãçšããŠéå ãããã(ii)é©åœãªäžæŽ»æ§æº¶åªäžãé
å±ãŸãã¯éå±å¡©ãšé žããããã¯éå±ãŸãã¯éå±å¡©
ãšã¢ã«ã«ãªéå±æ°Žé žåç©ãç¡«åç©ãŸãã¯ã¢ã³ã¢ã
ãŠã å¡©ãªã©ãšã®æ··åç©ãéå å€ãšããŠçšããŠéå
ããããšã«ããè¡ãªãããã (i)ã®æ¥è§Šéå ã«ããå Žåãçšãããã溶åªãšã
ãŠã¯ãäŸãã°æ°Žãé ¢é žãã¡ã¿ããŒã«ããšã¿ããŒ
ã«ãã€ãœãããããŒã«ããã¿ããŒã«ããšãã¬ã³ã°
ãªã³ãŒã«ãªã©ã®ã¢ã«ã³ãŒã«é¡ããžãšãã«ãšãŒã
ã«ããžã¡ãã«ãšãŒãã«ãããã©ããããã©ã³ããž
ãªããµã³ãã¢ãã°ã©ã€ã ããžã°ã©ã€ã ãªã©ã®ãšãŒ
ãã«é¡ããããµã³ãã·ã¯ããããµã³ãªã©ã®çåæ°Ž
çŽ é¡ãé ¢é žã¡ãã«ãé ¢é žãšãã«ãªã©ã®ãšã¹ãã«
é¡ãïŒïŒ®âãžã¡ãã«ãã«ã ã¢ãããªã©ã®éãã
ãã³æ§æ¥µæ§æº¶åªãªã©ãæãããããæ¥è§Šéå 觊åª
ãšããŠã¯ãäŸãã°ãã©ãžãŠã ããã©ãžãŠã é»ãã
ã©ãžãŠã ççŽ ãçœéãé žåçœéãäºã¯ãã é žé ã
ã©ããŒããã±ã«ãªã©ãæãããããããã觊åªã®
䜿çšéã¯ãååç©17ã«å¯ŸããŠ0.02ã1.00åïŒé
éïŒçšããã®ããããåå¿ã¯éåžžâ20ã150âã
奜ãŸããã¯ïŒâã宀枩ä»è¿ãæ°ŽçŽ å§ïŒã10æ°å§ã§
30åã10æéçšåºŠè¡ãªãããã (ii)ã®æ¹æ³ãçšããå Žåã«ã¯ãéå å€ãšããŠéã
äºéãé«ãŸãã¯å¡©å第äžé«ãšå¡©é žãç¡«é žãªã©ã®é±
é žãšã®çµåããéãç¡«é žç¬¬äžéãäºéãŸãã¯é«ãš
æ°Žé žåãããªãŠã ãªã©ã®ã¢ã«ã«ãªéå±æ°Žé žåç©ã
ç¡«åã¢ã³ã¢ããŠã ãªã©ã®ç¡«åç©ãã¢ã³ã¢ãã¢æ°Žã
å¡©åã¢ã³ã¢ããŠã ãªã©ã®ã¢ã³ã¢ããŠã å¡©ãªã©ãšã®
çµåããçšããããã䜿çšãããäžæŽ»æ§æº¶åªãšã
ãŠã¯ãäŸãã°æ°Žãé ¢é žãã¡ã¿ããŒã«ããšã¿ããŒ
ã«ããžãªããµã³ãªã©ãæãããããåå¿æž©åºŠãæ
éã¯çšãããã觊åªã®çš®é¡ã«ããé©å®éžæããã
äŸãã°ç¡«é žç¬¬äžéãšã¢ã³ã¢ãã¢æ°Žãšã®çµåãã®å Ž
åã«ã¯50ã150âä»è¿ã§30åã10æéçšåºŠã§æå©
ã«è¡ãªããããéå å€ã®äœ¿çšéã¯ãéåžžãååç©
17ã«å¯ŸããŠå°ãªããšãçã¢ã«ã奜ãŸããã¯çã¢ã«
ãïŒåã¢ã«ã§ããã ååç©18ãšååç©19ãšã®åå¿ã¯ãå¡©åºæ§ååç©
ã®ååšäžãé©åœãªæº¶åªäžã§è¡ãªãããšãã§ããã
å¡©åºæ§ååç©ãšããŠã¯äŸãã°æ°Žé žåãããªãŠã ã
çé žã«ãªãŠã ãçé žæ°ŽçŽ ãããªãŠã ãçé žæ°ŽçŽ ã«
ãªãŠã ãæ°ŽçŽ åãããªãŠã ããããªãŠã ã¡ãã©ãŒ
ãããããªãŠã ãšãã©ãŒããªã©ã®ç¡æ©å¡©åºãããª
ãšãã«ã¢ãã³ãããªãžã³ãαâãã³ãªã³ãïŒïŒ®
âãžã¡ãã«ã¢ããªã³ãâã¡ãã«ã¢ã«ããªã³ãã
ããªãžã³ããããªãžã³ãªã©ã®ã¢ãã³é¡ãªã©åºç¯å²
ã®ãã®ãçšããããã溶åªãšããŠã¯ãžãªããµã³ã
ããã©ããããã©ã³ãã°ã©ã€ã ããžã°ã©ã€ã ãªã©
ã®ãšãŒãã«é¡ããã«ãšã³ããã·ã¬ã³ãªã©ã®è³éŠæ
çåæ°ŽçŽ é¡ãã¡ã¿ããŒã«ããšã¿ããŒã«ãã€ãœãã
ãããŒã«ãªã©ã®äœçŽã¢ã«ã³ãŒã«é¡ããžã¡ãã«ãã«
ã ã¢ããããžã¡ãã«ã¹ã«ããã·ããªã©ã®æ¥µæ§æº¶åª
ãæãããããåå¿ã¯å®€æž©ã150âã奜ãŸããã¯
60ã120âã«ãŠïŒã24æéçšåºŠè¡ãªããããåå
ç©18ãšååç©19ã®äœ¿çšå²åã¯ç¹ã«å¶éãããªã
ããéåžžåè ã«å¯ŸããŠåŸè ãçã¢ã«ãéå°éã奜
ãŸããã¯çã¢ã«ãïŒåã¢ã«çšããã K0032 ãåŒäžãR2ã¯åèšã«åããã¯äœçŽã¢ã«ãã«
ã瀺ãã äžèšã®åå¿ã¯ãååç©20ãRCOXãŸãã¯
ïŒRCOïŒ2OãåŒäžïŒ²ã¯åèšã«åããã¯ããã²ã³å
åã瀺ãããšåå¿ãããŠãååç©20aã«ããã€ã¥
ããŠå æ°Žå解ããããšã«ããååç©13bãåŸãã
ãšãã§ãããäžè¬åŒïŒ20ïŒãšRCOXãŸãã¯
ïŒRCOïŒ2Oãšã®åå¿ã¯å¡©åºæ§ååç©ã®ååšäžãŸã
ã¯éååšäžã«è¡ãªãããã䜿çšãããå¡©åºæ§åå
ç©ãšããŠã¯äŸãã°éå±ãããªãŠã ãéå±ã«ãªãŠã
ãªã©ã®ã¢ã«ã«ãªéå±ããã³ãããã¢ã«ã«ãªéå±ã®
æ°Žé žåç©ãçé žå¡©ãéçé žå¡©ãããã¯ããªãžã³ã
ãããªãžã³ãªã©ã®è³éŠæã¢ãã³ååç©ãªã©ãæã
ãããã該åå¿ã¯ç¡æº¶åªãããã¯æº¶åªäžã®ããã
ã§ãé²è¡ããã溶åªãšããŠã¯ãäŸãã°ã¢ã»ãã³ã
ã¡ãã«ãšãã«ã±ãã³ãªã©ã®ã±ãã³é¡ããšãŒãã«ã
ãžãªããµã³ãªã©ã®ãšãŒãã«é¡ããã³ãŒã³ããã«ãš
ã³ããã·ã¬ã³ãªã©ã®è³éŠæçåæ°ŽçŽ é¡ãæ°Žãããª
ãžã³ãªã©ãæãããããRCOXãŸãã¯ïŒRCO2ïŒ
ã®ååç©ã®äœ¿çšéã¯ãäžè¬åŒïŒ20ïŒã®ååç©ã«
察ããŠãå°ããšãçã¢ã«çšããããããäžè¬ã«
ã¯ãçã¢ã«ã倧éå°éçšããã®ãããããŸã該å
å¿ã¯ãïŒã200âã§é²è¡ããããäžè¬ã«ã¯ïŒã150
âã§è¡ãªãã®ããããåå¿æéã¯ã0.5ã10æé
çšåºŠã§çµäºããã äžè¬åŒïŒ20aïŒã®å æ°Žå解åå¿ã¯ã氎溶液äžå
æ°Žå解觊åªãäŸãã°æ°Žé žåã«ãªãŠã ãæ°Žé žåãã
ãªãŠã ãªã©ã®ã¢ã«ã«ãªéå±æ°Žé žåç©ãçé žãããª
ãŠã ãçé žã«ãªãŠã ãçé žæ°ŽçŽ ãããªãŠã ãªã©ã®
ç¡æ©ã¢ã«ã«ãªååç©ã®ååšäžã«ãéåžž50ã150âã
奜ãŸããã¯70ã100âã«ãŠ0.5ã10æéçšåºŠå ç±ã
ãŠè¡ãªãããã K0033 ãåŒäžãR1ïŒR2ïŒR10ïŒïŒžïŒïŒ¡ïŒïœããã³ã«ã«
ãã¹ããªã«éªšæ žã®ïŒäœãšïŒäœéã®çµåã¯åèšã«å
ããR12ã¯è³éŠæã¢ãã³æ®åºã瀺ãã äžèšåå¿åŒã«ãããŠãååç©21ãšè³éŠæã¢ãã³
22ãšã®åå¿ã¯ãé©åœãªæº¶åªäžãŸãã¯ç¡æº¶åªäžã«è¡
ãªãããã溶åªãšããŠã¯åå¿ã«æªåœ±é¿ãäžããªã
äžæŽ»æ§ã®ãã®ããã¹ãŠçšããããäŸãã°ã¯ããã
ã«ã ãå¡©åã¡ãã¬ã³ããžã¯ããã¡ã¿ã³ãåå¡©åç
çŽ ãªã©ã®ããã²ã³åçåæ°ŽçŽ é¡ããžãšãã«ãšãŒã
ã«ãããã©ããããã©ã³ããžãªããµã³ããžã¡ãã
ã·ãšã¿ã³ãªã©ã®ãšãŒãã«é¡ãã¡ã¿ããŒã«ããšã¿ã
ãŒã«ãã€ãœãããããŒã«ããã¿ããŒã«ãªã©ã®ã¢ã«
ã³ãŒã«é¡ãé ¢é žã¡ãã«ãé ¢é žãšãã«ãªã©ã®ãšã¹ã
ã«é¡ãNNâãžã¡ãã«ãã«ã ã¢ããããžã¡ãã«ã¹
ã«ãããµã€ãããããµã¡ãã«ãªã³é žããªã¢ãããª
ã©ã®éãããã³æ§æ¥µæ§æº¶åªãã¢ã»ããããªã«ãªã©
ãæãããããè³éŠæã¢ãã³ãšããŠã¯ãããªãž
ã³ããããªã³ãªã©ãäŸç€ºã§ããã該è³éŠæã¢ãã³
ã®äœ¿çšéã¯ãååç©21ã«å¯ŸããŠå°ãªããšãçã¢
ã«ã奜ãŸããã¯å€§éå°éã§çšãããåå¿æž©åºŠã¯50
ã200âã奜ãŸããã¯70ã150âã§ãããïŒã10æ
éçšåºŠã§åå¿ã¯çµäºããã ããããååç©23ã®å æ°Žå解ã¯ãæ°Žäžãæ°Žé žå
ãããªãŠã ãæ°Žé žåã«ãªãŠã ã®ãããªç¡æ©å¡©åºã®
ååšäžã«å®€æž©ã150âã«ãŠïŒã10æéçšåºŠåŠçã
ãŠè¡ãªãããã ãŸãååç©23ã®ååç©14ã«ãããšã¹ãã«åã¯å¡©
åºæ§ååç©ã®ååšäžã溶åªäžãŸãã¯ç¡æº¶åªã«ãŠå
å¿ãããããšã«ããè¡ãªãããã䜿çšããã溶åª
ãšããŠã¯ãäŸãã°å¡©åã¡ãã¬ã³ãã¯ãããã«ã ã
ãžã¯ãããšã¿ã³ãªã©ã®ããã²ã³åçåæ°ŽçŽ é¡ãã
ã³ãŒã³ããã«ãšã³ããã·ã¬ã³ãªã©ã®è³éŠæçåæ°Ž
çŽ é¡ããžãšãã«ãšãŒãã«ãããã©ããããã©ã³ã
ãžãªããµã³ããžã¡ããã·ãšã¿ã³ãªã©ã®ãšãŒãã«
é¡ãïŒïŒ®âãžã¡ãã«ãã«ã ã¢ããããžã¡ãã«ã¹
ã«ããã·ãããããµã¡ãã«ãªã³é žããªã¢ãããªã©
ã®éãããã³æ§æº¶åªãªã©ãäŸç€ºã§ããã䜿çšãã
ãå¡©åºæ§è§ŠåªãšããŠã¯ãäŸãã°ããªãšãã«ã¢ã
ã³ãããªã¡ãã«ã¢ãã³ãããªãžã³ããžã¡ãã«ã¢ã
ãªã³ãâã¡ãã«ã¢ã«ããªã³ãïŒâãžã¡ãã«ã¢ã
ãããªãžã³ãïŒïŒïŒâãžã¢ã¶ãã·ã¯ãã4.3.0ã
ããã³âïŒïŒDBNïŒãïŒïŒïŒâãžã¢ã¶ãã·ã¯ã
ã5.4.0ããŠã³ãã»ã³âïŒïŒDBUïŒãïŒïŒïŒâãžã¢ã¶
ãã·ã¯ãã2.2.2ããªã¯ã¿ã³ïŒDABCOïŒãªã©ã®æ
æ©å¡©åºããã³çé žã«ãªãŠã ãçé žãããªãŠã ãç
é žæ°ŽçŽ ã«ãªãŠã ãçé žæ°ŽçŽ ãããªãŠã ãªã©ã®ç¡æ©
å¡©åºãªã©ãäŸç€ºã§ãããããã§äœ¿çšãããå¡©åºæ§
ååç©ã®äœ¿çšå²åãšããŠã¯ãäžè¬åŒïŒ23ïŒã®åå
ç©ã«å¯ŸããŠãå°ããšãçã¢ã«ã奜ãŸããã¯ïŒã
1.5åã¢ã«é䜿çšããã®ããããäžè¬åŒïŒ14ïŒã®
ååç©ã®äœ¿çšå²åã¯ãäžè¬åŒïŒ23ïŒã®ååç©ã«å¯Ÿ
ããŠãå°ãªããšãçã¢ã«ãé垞倧éå°éã§äœ¿çšã
ãã®ããããåå¿æž©åºŠã¯ãé垞宀枩ã150âã奜
ãŸããã¯50ã100âä»è¿ã§ããã該åå¿ã¯äžè¬ã«
30åã10æéã§çµäºããã K0034 K0035 K0036 ãåŒäžãR11ããã³ïŒžã¯åèšã«åããXâ²ã¯æ°ŽçŽ
ååãŸãã¯ããã²ã³ååã瀺ãã äžèšåå¿åŒã«ãããŠãååç©24ãšååç©25ãŸã
ã¯26ãšã®åå¿ã¯äžè¬ã«ããªãŒãã«ã¯ã©ããåå¿ãš
åŒã°ãããã®ã§ãããéåžžãé©åœãªæº¶åªäžãã«ã€
ã¹é žã®ååšäžã«è¡ãªããããçšãããã溶åªãšã
ãŠã¯ãã®çš®ã®åå¿ã«é垞䜿çšããããã®ãæå©ã«
çšããããäŸãã°äºç¡«åççŽ ãããããã³ãŒã³ã
ã¯ãããã³ãŒã³ããžã¯ããã¡ã¿ã³ããžã¯ãããšã¿
ã³ãããªã¯ãããšã¿ã³ãåå¡©åççŽ ãªã©ãæãã
ãããã«ã€ã¹é žãšããŠãéåžžçšãããããã®ãã
ã¹ãŠäœ¿çšãããäŸãã°å¡©åã¢ã«ãããŠã ãå¡©åäº
éãå¡©åéãå¡©åé«ãäžèåããŠçŽ ãäžããåã
ãŠçŽ ãæ¿ç¡«é žãªã©ãæãããããã«ã€ã¹é žã®äœ¿çš
éã¯é©å®æ±ºå®ããããããéåžžãååç©24ã«å¯Ÿã
ãŠïŒãïŒåã¢ã«çšåºŠã奜ãŸããã¯ïŒãïŒåã¢ã«ã§
ãããååç©25ãŸãã¯26ã®äœ¿çšéã¯ååç©24ã«å¯Ÿ
ããŠãéåžžãå°ãªããšãçã¢ã«ã奜ãŸããã¯çã¢
ã«ãïŒåã¢ã«ã§ãããåå¿æž©åºŠã¯éåžžâ50ã120
âçšåºŠã奜ãŸããã¯ïŒã70âã§ããããŸãåå¿æ
éã¯çšããåæã觊åªãåå¿æž©åºŠãªã©ã«ãã€ãŠã
ç°ãªãããéåžžã30åã24æéçšåºŠã§ããã ããããååç©27ã®ãããåã¯ãéåžžã®è³éŠæ
ååç©ã®ãããååå¿ãšåæ§ã®æ¡ä»¶äžã«è¡ãªã
ããäŸãã°é©åœãªäžæŽ»æ§æº¶åªäžãŸãã¯ç¡æº¶åªäžã«
ãããåå€ãäœçšãããŠè¡ãªããäžæŽ»æ§æº¶åªãšã
ãŠã¯ãäŸãã°é ¢é žãç¡æ°Žé ¢é žãæ¿ç¡«é žãªã©ãæã
ããããŸããããåå€ãšããŠã¯ãäŸãã°çºç ç¡
é žãæ¿ç¡é žãç¡é žãšä»ã®é žïŒç¡«é žãçºç ç¡«é žããª
ã³é žãç¡æ°Žé ¢é žïŒãšã®æ··é žãç¡é žã«ãªãŠã ãç¡é ž
ãããªãŠã ãªã©ã®ã¢ã«ã«ãªéå±ç¡é žå¡©ãšç¡«é žãªã©
ã®é±é žãšã®æ··åç©ãªã©ãæããããã該ãããå
å€ã®äœ¿çšéã¯ååç©27ã«å¯ŸããŠçã¢ã«ä»¥äžãéåžž
éå°éã§ãããåå¿æž©åºŠã¯â10âã宀枩ä»è¿ã奜
ãŸãããïŒåãïŒæéåå¿ãããã ããããååç©28ã¯éå ãéç°ã«ããååç©
13eã«å°ãããããã®åå¿ã¯åèšåå¿åŒâXIã«ã
ããååç©17ã®éå åå¿æ¡ä»¶ãšåæ§ã®æ¡ä»¶äžã«è¡
ãªããããã(i)ã®æ¥è§Šéå æ¹æ³ãçšããå Žåã¯ã
åå¿æž©åºŠã¯ã奜ãŸããã¯ïŒã50âã§ããããŸãå
å¿ç³»å ã«æ°Žé žåãããªãŠã ãæ°Žé žåã«ãªãŠã ãªã©
ã®å¡©åºæ§ååç©ãååšãããããšã«ããåå¿ãæ
å©ã«é²è¡ãããããã«(ii)ã®æ¹æ³ãçšããå Žåã«
ã¯ãéåžžâ50ã100âã«ãããŠåå¿ã¯é²è¡ãã0.5
ã10æéçšåºŠã§åå¿ã¯çµäºãããäŸãã°ãå¡©å第
ïŒé«ãšå¡©é žãšãéå å€ãšããŠçšããå Žåãæå©ã«
ã¯â20ã50âä»è¿ã«ãŠåå¿ãè¡ãªãã®ããããé
å å€ã®äœ¿çšéãšããŠã¯ãåæååç©ã«å¯ŸããŠå°ã
ãšãçã¢ã«éãéåžžã¯çã¢ã«ãïŒåã¢ã«éçšãã
ã®ããããäžèšã®æ¹æ³ã«ãããããåºã®éå ãšå
æã«éç°ããŠååç©13eãããããããã ãã(i)
ã®æ¥è§Šéå 觊åªãçšããå Žåã«ã¯ã«ã«ããã«åºã
éå ãããŠã¡ãã¬ã³ã«å€æãããå Žåããããã
åå¿æ¡ä»¶ãé©åœã«éžæããããšã«ãããã®ãããª
å€æã¯é¿ããããã K0037 K0038 ãåŒäžãR2ïŒR11ããã³ïŒžã¯åèšã«åããR13
ã¯äœçŽã¢ã«ãã«ã瀺ãã äžèšåå¿åŒã«ãããŠååç©29ãšååç©30ãšã®å
å¿ã¯ãéåžžãè±ããã²ã³åæ°ŽçŽ å€ã®ååšäžãŸãã¯
äžååšäžã«é©åœãªæº¶åªäžã§è¡ãªããããè±ããã²
ã³åæ°ŽçŽ å€ãšããŠã¯éåžžå¡©åºæ§ååç©ãçšãã
ããäŸãã°ãããªãšãã«ã¢ãã³ãããªã¡ãã«ã¢ã
ã³ãããªãžã³ããžã¡ãã«ã¢ããªã³ãâã¡ãã«ã¢
ã«ããªã³ãïŒâãžã¡ãã«ã¢ããããªãžã³ãïŒïŒïŒ
âãžã¢ã¶ãã·ã¯ãã4.3.0ãããã³âïŒïŒDBNïŒã
ïŒïŒïŒâãžã¢ã¶ãã·ã¯ãã5.4.0ããŠã³ãã»ã³â
ïŒïŒDBUïŒãïŒïŒïŒâãžã¢ã¶ãã·ã¯ãã2.2.2ããª
ã¯ã¿ã³ïŒDABCOïŒãªã©ã®ææ©å¡©åºãçé žã«ãªãŠ
ã ãçé žãããªãŠã ãçé žæ°ŽçŽ ã«ãªãŠã ãçé žæ°Ž
çŽ ãããªãŠã ãæ°Žé žåãããªãŠã ãæ°Žé žåã«ãªãŠ
ã ãæ°ŽçŽ åãããªãŠã ãæ°ŽçŽ åã«ãªãŠã ãçé ž
éããããªãŠã ã¡ãã©ãŒãããããªãŠã ãšãã©ãŒ
ããªã©ã®ã¢ã«ã«ãªéå±ã¢ã«ã³ã©ãŒããªã©ãæãã
ããããªãåå¿ååç©ã®ååç©30ãéå°éçšããŠ
è±ããã²ã³åæ°ŽçŽ å€ãšããŠå Œçšãããããšãã§ã
ãã溶åªãšããŠã¯å¡©åã¡ãã¬ã³ãã¯ãããã«ã ã
ãžã¯ãã«ãšã¿ã³ãªã©ã®ããã²ã³åççŽ é¡ããã³ãŒ
ã³ããã«ãšã³ããã·ã¬ã³ãªã©ã®è³éŠæçåæ°ŽçŽ
é¡ããžãšãã«ãšãŒãã«ãããã©ããããã©ã³ããž
ã¡ããã·ãšã¿ã³ãªã©ã®ãšãŒãã«é¡ãé ¢é žã¡ãã«ã
é ¢é žãšãã«ãªã©ã®ãšã¹ãã«é¡ããžã¡ãã«ãã«ã ã¢
ããããžã¡ãã«ã¹ã«ããã·ãããããµã¡ãã«ãªã³
é žããªã¢ãããªã©ã®éãããã³æ§æ¥µæ§æº¶åªãããª
ãžã³ãã¢ã»ãã³ãã¢ã»ããããªã«ãããã«ã¡ã¿ã
ãŒã«ããšã¿ããŒã«ããããããŒã«ããã¿ããŒã«ã
ïŒâã¡ããã·âïŒâãã¿ããŒã«ããšãã«ã»ããœã«
ããã¡ãã«ã»ããœã«ããªã©ã®ã¢ã«ã³ãŒã«é¡ãããª
ãžã³ãã¢ã»ãã³ãã¢ã»ããããªã«ãªã©ããŸãã¯ã
ããã®ïŒçš®ä»¥äžã®æ··å溶åªãæãããããååç©
29ãšååç©30ãšã®äœ¿çšå²åã¯ç¹ã«éå®ãããåºç¯
å²ã«éžæãããããéåžžåè ã«å¯ŸããŠåŸè ãå°ãª
ããšãçã¢ã«ã奜ãŸããã¯çã¢ã«ãïŒåã¢ã«çšã
ããããåå¿æž©åºŠã¯éåžžâ30ã180âçšåºŠã奜ãŸ
ããã¯çŽïŒã150âã§ãäžè¬ã«ïŒåã30æéã§å
å¿ã¯å®çµããã ååç©31ã®éç°åå¿ã¯ãé©åœãªæº¶åªäžãŸãã¯ç¡
溶åªäžã«é žã®ååšäžã«è¡ãªããããé žãšããŠã¯ç¹
ã«éå®ãããéåžžã®ææ©é žãŸãã¯ãç¡æ©é žãçšã
ãããäŸãã°å¡©é žãèåæ°ŽçŽ é žãç¡«é žãªã©ã®ç¡æ©
é žãå¡©åã¢ã«ãããŠã ãäžããåããŠçŽ ãåå¡©å
ãã¿ã³ãªã©ã®ã«ã€ã¹é žãã®é žãé ¢é žããšã¿ã³ã¹ã«
ãã³é žãïœâãã«ãšã³ã¹ã«ãã³é žãªã©ã®ææ©é žã
æããããããããã®ãã¡ãå¡©é žãèåæ°ŽçŽ é žã
ç¡«é žãªã©ã®ç¡æ©é žã奜ãŸãããé žã®äœ¿çšéã¯ç¹ã«
éå®ããããéåžžãååç©31ã«å¯ŸããŠå°ãªããšã
çééã奜ãŸããã¯10ã50åééã§ããããŸã溶
åªãšããŠã¯éåžžã®äžæŽ»æ§æº¶åªãçšããããäŸãã°
æ°Žãã¡ã¿ããŒã«ããšã¿ããŒã«ããããããŒã«ãªã©
ã®äœçŽã¢ã«ã³ãŒã«é¡ããžãªããµã³ãããã©ããã
ãã©ã³ãªã©ã®ãšãŒãã«é¡ããã³ãŒã³ããã«ãšã³ã
ãã·ã¬ã³ãªã©ã®è³éŠæçåæ°ŽçŽ é¡ãå¡©åã¡ãã¬
ã³ãã¯ãããã«ã ãåå¡©åççŽ ãªã©ã®ããã²ã³å
çåæ°ŽçŽ é¡ãã¢ã»ãã³ããžã¡ãã«ã¹ã«ããã·ãã
ãžã¡ãã«ãã«ã ã¢ããããããµã¡ãã«ãªã³é žããª
ã¢ãããªã©ã®éãããã³æ§æ¥µæ§æº¶åªãªã©ãæãã
ããããããã®ãã¡ãäœçŽã¢ã«ã³ãŒã«é¡ããšãŒã
ã«é¡ãã¢ã»ãã³ããžã¡ãã«ã¹ã«ããã·ãããžã¡ã
ã«ãã«ã ã¢ããããããµã¡ãã«ãªã³é žããªã¢ãã
ãªã©ã®æ°Žæº¶æ§æº¶åªã奜ãŸããã該åå¿ã¯éåžžïŒã
100âã奜ãŸããã¯å®€æž©ã60âã§è¡ãªãããéåžž
ïŒåãïŒæéçšåºŠã§çµäºããã ãªãã該ååç©13ã13fããã³15ã¯ãåèšåå¿
åŒâããã³ã«ç€ºãããâã¢ã«ãã«åæ¹æ³ãª
ãã³ã«åå¿åŒâããã³ã«ç€ºãããè±æ°ŽçŽ åå¿
ãŸãã¯éå åå¿ãå©çšããæ¹æ³ãªã©ã«ãããåæ§
ã«å¯Ÿå¿ããä»ã®åŒïŒ13ïŒãïŒ13fïŒããã³ïŒ15ïŒ
ã®ååç©ã«å°ãããšãã§ããã ããã«ãåèšåå¿åŒâXIã«ãããäžéäœã§ãã
ååç©ïŒïŒããã³ååç©ïŒãªãã³ã«åèšåå¿åŒâ
ã«ãããåºçºç©è³ªã§ããååç©21ãªã©ã¯äžèš
åå¿åŒâãXIã«ç€ºãããæ¹æ³ã«ãã€ãŠã補
é ãããã K0039 ãåŒäžãR1ïŒïŒžïŒXâ²ããã³ã«ã«ãã¹ããªã«éªš
æ žã®ïŒäœãšïŒäœéã®çµåã¯åèšãšåãã äžèšã®ååç©32ãšååç©25ãŸãã¯26ãšã®åå¿
ã¯ãåèšåå¿åŒâã«ãããååç©24ãšååç©
25ãŸãã¯26ãšã®åå¿ãšåæ§ã®æ¡ä»¶äžã«è¡ãªãã
ãããã ããåå¿æž©åºŠã¯éåžž20ã120âã奜ãŸã
ãã¯40ã70âçšåºŠã§ãåå¿æéã¯åæã觊åªãå
å¿æž©åºŠã«ããç°ãªãããéåžž30åã24æéçšåºŠã§
ããã K0040 ãåŒäžãR1ïŒR2ïŒïŒ¡ïŒïœããã³ã«ã«ãã¹ããª
ã«éªšæ žã®ïŒäœãšïŒäœéã®çµåã¯åèšã«åããR14
ã¯æ°ŽçŽ ååãäœçŽã¢ã«ãã«ãŸãã¯åº
ãåŒã
ã瀺ãã
äžèšåå¿åŒã«ãããŠååç©ïŒïŒãéå
ããŠåå
ç©ïŒã«å°ãåå¿ã¯ãåèšåå¿åŒâXIã«ãããåå
ç©13ãååç©ïŒïŒã«éå ããå Žåãšåæ§ã®éå æ¡
件äžããªãã³ã«åèšåå¿åŒâã«ãããååç©
ïŒâ²ãååç©ïŒâ³ã«å°ãå Žåã®æ¥è§Šéå æ³ãšåæ§ã®
æ¡ä»¶äžã«è¡ãªãããã ååç©ïŒãããã«éå ããŠååç©ïŒïŒã«å°ãæ¹
æ³ã¯ãçš®ã ã®æ¹æ³ãããããäŸãã°æ°ŽçŽ åéå å€
ãçšããéå æ³ã奜é©ã«å©çšããããçšãããã
æ°ŽçŽ åéå å€ãšããŠã¯ãäŸãã°æ°ŽçŽ åã¢ã«ãããŠ
ã ãããªãŠã ãæ°ŽçŽ åããªâtertâãããã·ã¢ã«
ãããŠã ãªããŠã ãæ°ŽçŽ åãžã€ãœããã«ã¢ã«ãã
ãŠã ãæ°ŽçŽ åïŒïŒïŒïŒâãžã¡ãã«âïŒâãžã€ãœã
ããã«ã¡ãã«ïŒããŠçŽ ãïŒïœâC3H7ïŒ
ïŒCH3ïŒ2CBH2ããªã©ãæãããããã®äœ¿çšéã¯ã
éåžžãååç©ïŒã«å¯ŸããŠçééã§ããããã®éå
åå¿ã¯ãäŸãã°ãžãšãã«ãšãŒãã«ãããã©ããã
ãã©ã³ããžã°ã©ã€ã ãªã©ã®é©åœãªæº¶åªäžãéåžžã
â60ã50âçšåºŠã奜ãŸããã¯â30âã宀枩ã«ãŠè¡
ãªããã10åéãïŒæéã§çµäºããã K0042 ãåŒäžãR2ïŒïŒ¡ïŒïœããã³ïŒžã¯åèšã«åãã äžèšåå¿åŒã«ãããååç©ïŒïŒã®éç°åå¿ã¯ã
åèšåå¿åŒâã«ãããååç©11ã®éç°åå¿ãšå
æ§ã®æ¡ä»¶äžã«è¡ãªããããŸãååç©ïŒïŒããåå
ç©9bã«å°ãåå¿ãåèšåå¿åŒâã«ãããåå
ç©12ããååç©6aãããåå¿ãšåãæ¡ä»¶äžã«è¡
ãªãããã K0043 ãåŒäžãR2ããã³ã¯åèšã«åãã äžèšåå¿åŒã«ãããŠãååç©37ã®ããã²ã³åå
å¿ã¯ãé©åœãªæº¶åªäžååç©37ãããã²ã³åå€ã§åŠ
çããŠè¡ãªããããçšããããããã²ã³åå€ãšã
ãŠã¯äŸãã°å¡©çŽ ãèçŽ ãªã©ã®ããã²ã³ååãâ
ããã¢ã³ãã¯é žã€ãããâã¯ããã³ãã¯é žã€ã
ããªã©ã®ïŒ®âããã²ãã³ãã¯é žã€ãããå¡©åã¹ã«
ããªã«ãå¡©åé ãèåé ãªã©ã®ããã²ã³åé ãªã©
ãæããããã溶åªãšããŠã¯ãžã¯ããã¡ã¿ã³ããž
ã¯ãããšã¿ã³ãã¯ãããã«ã ãåå¡©åççŽ ãªã©ã®
ããã²ã³åçåæ°ŽçŽ é¡ããžãšãã«ãšãŒãã«ããã
ã©ããããã©ã³ããžãªããµã³ãªã©ã®ãšãŒãã«é¡ã
é ¢é žãªã©ãäŸç€ºã§ããããã®ããã²ã³åå€ã®äœ¿çš
éã¯ãååç©37ã«å¯ŸããŠçã¢ã«ãéå°éã奜ãŸã
ãã¯çã¢ã«ã1.2åã¢ã«ã§ããã該åå¿ã¯éåžžïŒ
âã溶åªã®æ²žç¹ä»è¿ã奜ãŸããã¯å®€æž©ã40âã§ã
ããéåžžïŒã10æéçšåºŠã§çµäºããããªãããã®
åå¿ã«éé žåãã³ãŸã€ã«ãéé žåæ°ŽçŽ ãªã©ã®éé ž
åç©ã®ãããªã©ãžã«ã«åå¿éå§å€ãçšããŠãã
ãã ååç©38ãéç°ãããŠååç©9cã«å°ãåå¿ã¯é©
åœãªæº¶åªäžçž®åå€ã®ååšäžã«è¡ãªããããçšãã
ããçž®åå€ãšããŠã¯ãäŸãã°äºé žåãªã³ãããå
æ°ŽçŽ ãç¡«é žãããªãªã³é žãå¡©åã¢ã«ãããŠã ãå¡©
åäºéãªã©ã®ã«ã€ã¹é žãªã©ãæããããã溶åªãš
ããŠã¯ã¯ãããã«ã ããžã¯ããã¡ã¿ã³ãïŒïŒïŒâ
ãžã¯ãããšã¿ã³ãªã©ã®ããã²ã³åçåæ°ŽçŽ é¡ããž
ãšãã«ãšãŒãã«ããžãªããµã³ãªã©ã®ãšãŒãã«é¡ã
ããããã³ãŒã³ãã¯ãããã³ãŒã³ãªã©ã®è³éŠæç
åæ°ŽçŽ é¡ãªã©ãäŸç€ºã§ãããååç©38ãšçž®åå€ãš
ã®äœ¿çšå²åã¯ç¹ã«éå®ãããªãããéåžžãåè ã«
察ããŠåŸè ãçã¢ã«ã10åã¢ã«ã奜ãŸããã¯ïŒã
ïŒåã¢ã«ãšããã®ãããããã®åå¿ã¯ãéåžžã50
ã250âã奜ãŸããã¯70ã200âã«ãŠ20åãïŒæé
çšåºŠè¡ãªãããã K0044 ãåŒäžãR1ïŒR2ïŒïŒžïŒïŒ¡ïŒïœããã³ã«ã«ãã¹
ããªã«éªšæ žã®ïŒäœãšïŒäœéã®çµåã¯åèšã«åãã
R15ã¯äœçŽã¢ã«ã«ãã€ã«ã瀺ãã äžèšåå¿åŒã«ãããååç©ïŒãšååç©39ãšã®å
å¿ã¯ã奜ãŸããã¯å¡©åºæ§ååç©ãè±ããã²ã³åæ°Ž
çŽ å€ãšããŠçšããé©åœãªæº¶åªäžã宀枩ã200âã
奜ãŸããã¯å®€æž©ã150âã«ãŠæ°æéã15æéçšåºŠ
è¡ãªããããçšãããã溶åªãšããŠã¯ãäŸãã°ã¡
ã¿ããŒã«ããšã¿ããŒã«ãã€ãœãããããŒã«ãªã©ã®
äœçŽã¢ã«ã³ãŒã«é¡ããžãšãã«ãšãŒãã«ãããã©ã
ãããã©ã³ããžãªããµã³ããšãã¬ã³ã°ãªã³ãŒã«ã¢
ãã¡ãã«ãšãŒãã«ããžãšãã¬ã³ã°ãªã³ãŒã«ãžã¡ã
ã«ãšãŒãã«ãªã©ã®ãšãŒãã«é¡ããã³ãŒã³ããã«ãš
ã³ããã·ã¬ã³ãªã©ã®è³éŠæçåæ°ŽçŽ é¡ãã¢ã»ã
ã³ãã¡ãã«ãšãã«ã±ãã³ãªã©ã®ã±ãã³é¡ããžã¡ã
ã«ãã«ã ã¢ããããžã¡ãã«ã¹ã«ããã·ãããããµ
ã¡ãã«ããªã³é žããªã¢ãããç¡æ°Žé ¢é žãªã©ãæã
ããããå¡©åºæ§ååç©ãšããŠã¯ãäŸãã°æ°Žé žåã
ããªãŠã ãæ°Žé žåã«ãªãŠã ãçé žãããªãŠã ãç
é žã«ãªãŠã ãçé žæ°ŽçŽ ãããªãŠã ãçé žæ°ŽçŽ ã«ãª
ãŠã ãçé žéãªã©ã®ç¡æ©å¡©åºããããªãŠã ãã«ãª
ãŠã ãªã©ã®ã¢ã«ã«ãªéå±ããããªãŠã ã¢ãããæ°Ž
çŽ åãããªãŠã ããããªãŠã ã¡ãã©ãŒãããããª
ãŠã ãšãã©ãŒããã«ãªãŠã ãšãã©ãŒããªã©ã®ã¢ã«
ã³ã©ãŒããããªãšãã«ã¢ãã³ãããªãããã«ã¢ã
ã³ãããªãžã³ããããªã³ãïŒïŒ®âãžã¡ãã«ã¢ã
ãªã³ãâã¡ãã«ã¢ã«ããªã³ãªã©ã®ç¬¬äžçŽã¢ãã³
é¡ãæãããããäžèšåå¿ã«ãããŠåå¿ä¿é²å€ãš
ããŠãšãŠåã«ãªãŠã ããšãŠåãããªãŠã ãªã©ã®ãš
ãŠåã¢ã«ã«ãªéå±ãçšããŠããããååç©ïŒãšå
åç©39ãšã®äœ¿çšå²åã¯ç¹ã«å¶éãããªãããé
åžžãåè ã«å¯ŸããŠåŸè ãå°ãªããšãçã¢ã«ã奜ãŸ
ããã¯ïŒãïŒã¢ã«çšåºŠã§ããã ããããååç©40ãå æ°Žå解ããã°ååç©ïŒïŒ
ã«å°ãããããã®å æ°Žå解åå¿ã¯ãäŸãã°å¡©é žã
èåæ°ŽçŽ é žãªã©ã®ããã²ã³åæ°ŽçŽ é žé¡ãç¡«é žããª
ã³é žãªã©ã®é±é žé¡ãæ°Žé žåã«ãªãŠã ãæ°Žé žåãã
ãªãŠã ãªã©ã®ã¢ã«ã«ãªéå±æ°Žé žåç©ãçé žãããª
ãŠã ãçé žã«ãªãŠã ãçé žæ°ŽçŽ ãããªãŠã ãªã©ã®
ã¢ã«ã«ãªéå±çé žå¡©ãŸãã¯éçé žå¡©ãªã©ã®ååšäž
ã«ãéåžžã50ã150âã奜ãŸããã¯70ã100âã«ãŠ
ïŒã24æéçšåºŠå ç±åå¿ããããšã«ããè¡ãªãã
ãã ãªãããããååç©ïŒããã³ïŒïŒã¯ãåèšåå¿
åŒâããã³ã«ç€ºãããâã¢ã«ãã«åæ³ãªã
ã³ã«åå¿åŒâããã³ã«ç€ºãããè±æ°ŽçŽ åå¿ãŸ
ãã¯éå åå¿ãå©çšããæ¹æ³ãªã©ã«ãããåæ§ã«
ä»ã®åŒ(9)ãŸãã¯ïŒ16ïŒã®ååç©ã«å°ãããšãã§ã
ãã åèšåå¿åŒâXIã®ååç©13ã¯ãäŸãã°ãäžèšå
å¿åŒâXIIã®æ¹æ³ã«ãã€ãŠã補é ãããã K0045 K0046 ãåŒäžãR1ïŒR2ïŒïŒ¡ããã³ã«ã«ãã¹ããªã«éªš
æ žã®ïŒäœãšïŒäœã®çµåã¯åèšã«åããR16ã¯äœçŽ
ã¢ã«ãã«åºãnâ²ã¯ïŒã瀺ãã ååç©ïŒïŒãšååç©ïŒïŒãšã®åå¿ã¯ãåèšåå¿
åŒâã«ãããååç©ïŒãšååç©10ãšã®åå¿ãšå
æ§ã®æ¡ä»¶äžã«è¡ãªããããååç©ïŒïŒã®å æ°Žå解
åå¿ã¯ãåèšåå¿åŒâã«ãããååç©ïŒã®å æ°Ž
å解åå¿ãšåæ§ã®æ¡ä»¶äžã§è¡ãªãããã ååç©ïŒïŒãšããŠã¯ãäŸãã°ã·ã¢ã³åã«ãªãŠ
ã ãã·ã¢ã³åãããªãŠã ãã·ã¢ã³åéãã·ã¢ã³å
é ãã·ã¢ã³åã«ã«ã·ãŠã ãªã©ãæãããããåå
ç©ïŒïŒãšååç©ïŒïŒãšã®åå¿ã¯ãé©åœãªæº¶åªäžã§
è¡ãªããããçšãããã溶åªãšããŠã¯ãäŸãã°
æ°Žãã¡ã¿ããŒã«ããšã¿ããŒã«ãã€ãœãããããŒã«
ãªã©ã®äœçŽã¢ã«ã«ããŒã«é¡ããŸãã¯æ°ŽãšäœçŽã¢ã«
ã«ããŒã«é¡ãšã®æ··å溶åªãæãããããååç©ïŒ
ïŒã®äœ¿çšéã¯ãååç©ïŒïŒã«å¯ŸããŠå°ãªããšãç
ã¢ã«ã奜ãŸããã¯ïŒã1.5åã¢ã«ã§ããã該åå¿
ã¯é垞宀枩ã150âã奜ãŸããã¯50ã120âä»è¿
ã§ã30åã10æéçšåºŠè¡ãªãããã ãŸãååç©ïŒïŒã®å æ°Žå解åå¿ãäžèšååç©ïŒ
ã®å æ°Žå解åå¿ãšåæ§ã®æ¡ä»¶äžã«è¡ãªãããã ãŸãååç©13â²ã®ææã®ççŽ æ°ã®ãã®ã¯ãåèš
åå¿åŒâXIã®åå¿ããã³åå¿åŒâXIIã®åå¿ã®å¢
ççŽ åå¿ãé©å®çµåããŠç¹°è¿ãããšã«ããåŸãã
ãã æ¬çºæã®ååç©ïŒã¯ãŸãäžèšã®åå¿åŒã®
æ¹æ³ã«ãã€ãŠã補é ãããã K0047 K0048 ãåŒäžãR1ïŒR2ïŒR4â²ïŒR16ïŒïŒ¡ïŒnâ²ïŒïŒžïŒ
Xâ²ããã³ã«ã«ãã¹ããªã«éªšæ žã®ïŒäœããã³ïŒäœ
ã®çµåã¯åèšã«åãã ååç©41ãšååç©46ã®åå¿ã¯ãåèšåå¿åŒâ
ã«ãããååç©ïŒãšååç©10ãšã®åå¿ãšåæ§ã®æ¡
件äžã§è¡ãªããããååç©47ã®å æ°Žå解åå¿ã¯å
èšåå¿åŒâã«ãããååç©ïŒã®å æ°Žå解åå¿ãš
åæ§ã®æ¡ä»¶äžã«è¡ãªãããã ååç©48ãšååç©49ãšã®åå¿ã¯æº¶åªäžãŸãã¯ç¡
溶åªã§ãå¡©åºæ§ååç©ã®ååšäžã«è¡ãªããããçš
ãããã溶åªãšããŠã¯ããžãªããµã³ãããã©ãã
ããã©ã³ããšãã¬ã³ã°ãªã³ãŒã«ããžã¡ãã«ãšãŒã
ã«ããžãšãã«ãšãŒãã«ãªã©ã®ãšãŒãã«é¡ããã³ãŒ
ã³ããã«ãšã³ããã·ã¬ã³ãªã©ã®è³éŠæçåæ°ŽçŽ
é¡ãã¡ã¿ããŒã«ããšã¿ããŒã«ãã€ãœãããããŒã«
ãªã©ã®ã¢ã«ã³ãŒã«é¡ããžã¡ãã«ãã«ã ã¢ããããž
ã¡ãã«ã¹ã«ããã·ãããããµã¡ãã«ãªã³é žããªã¢
ãããã¢ã»ãã³ãªã©ã®æ¥µæ§æº¶åªãªã©ãæããã
ãã䜿çšãããå¡©åºæ§è§ŠåªãšããŠã¯ãçé žã«ãªãŠ
ã ãçé žãããªãŠã ãæ°Žé žåãããªãŠã ãæ°Žé žå
ã«ãªãŠã ãçé žæ°ŽçŽ ãããªãŠã ãçé žæ°ŽçŽ ã«ãªãŠ
ã ããããªãŠã ã¢ãããæ°ŽçŽ åãããªãŠã ãªã©ã®
ç¡æ©å¡©åºãããªãšãã«ã¢ãã³ãããªãããã«ã¢ã
ã³ãããªãžã³ããããªã³ãªã©ã®ææ©å¡©åºãæãã
ããã該åå¿ã¯é垞宀枩ã200âã奜ãŸããã¯å®€
æž©ã150âã§ãïŒã30æéçšåºŠè¡ãªãããããŸã
åå¿ç³»ã«ãšãŠåã«ãªãŠã ãŸãã¯ãšãŠåãããªãŠã
ãªã©ã®ã¢ã«ã«ãªéå±ãšãŠåç©ããããµã¡ãã«ãªã³
é žããªã¢ãããªã©ãå ããããšã«ããåå¿ã容æ
ã«é²è¡ãããäžèšåå¿ã«ãããååç©49ã®äœ¿çšå²
åã¯ãååç©48ã«å¯ŸããŠãéåžžãçã¢ã«ã倧éå°
éã奜ãŸããã¯çã¢ã«ãïŒåã¢ã«ã§ããã æ¬çºæååç©ã¯æ朰çå€ãšããŠæçšã§ãããé
åžžãäžè¬çãªå»è¬è£œå€ã®åœ¢æ ã§çšããããã補å€
ã¯é垞䜿çšãããå å¡«å€ãå¢éå€ãçµåå€ãä»æ¹¿
å€ã厩å£å€ãè¡šé¢æŽ»æ§å€ãæ»æ²¢å€ãªã©ã®çšéå€ã
ããã¯è³Šåœ¢å€ãçšããŠèª¿è£œãããããã®å»è¬è£œå€
ãšããŠã¯åçš®ã®åœ¢æ ãæ²»çç®çã«å¿ããŠéžæã§
ãããã®ä»£è¡šçãªãã®ãšããŠé å€ãäžžå€ãæ£å€ã
液å€ãæžæ¿å€ãä¹³å€ãé¡ç²å€ãã«ãã»ã«å€ãå
å€ã泚å°å€ïŒæ¶²å€ãæžæ¿å€çïŒãªã©ãæããã
ããé å€ã®åœ¢æ ã«æ圢ããã«éããŠã¯ãæ äœãšã
ãŠãã®åéã§åŸæ¥å ¬ç¥ã®ãã®ãåºã䜿çšã§ããäŸ
ãã°ä¹³ç³ãçœç³ãå¡©åãããªãŠã ããããŠç³ãå°¿
çŽ ããã³ãã³ãçé žã«ã«ã·ãŠã ãã«ãªãªã³ãçµæ¶
ã»ã«ããŒã¹ãã±ã€é žãªã©ã®è³Šåœ¢å€ãæ°Žããšã¿ããŒ
ã«ããããããŒã«ãåã·ãããããããŠç³æ¶²ãã
ã³ãã³æ¶²ããŒã©ãã³æº¶æ¶²ãã«ã«ããã·ã¡ãã«ã»ã«
ããŒã¹ãã»ã©ãã¯ãã¡ãã«ã»ã«ããŒã¹ããªã³é žã«
ãªãŠã ãããªããã«ãããªãã³ãªã©ã®çµåå€ã也
ç¥ãã³ãã³ãã¢ã«ã®ã³é žãããªãŠã ãã«ã³ãã³
æ«ãã©ããã©ã³æ«ãçé žæ°ŽçŽ ãããªãŠã ãçé žã«
ã«ã·ãŠã ãããªãªãã·ãšãã¬ã³ãœã«ãã¿ã³èèªé ž
ãšã¹ãã«é¡ãã©ãŠãªã«ç¡«é žãããªãŠã ãã¹ãã¢ãª
ã³é žã¢ãã°ãªã»ãªãããã³ãã³ãä¹³ç³ãªã©ã®åŽ©å£
å€ãçœç³ãã¹ãã¢ãªã³ãã«ã«ãªãã¿ãŒãæ°ŽçŽ æ·»å
æ²¹ãªã©ã®åŽ©å£æå¶å€ã第åçŽã¢ã³ã¢ããŠã å¡©åºã
ã©ãŠãªã«ç¡«é žãããªãŠã ãªã©ã®åžåä¿é²å€ãã°ãª
ã»ãªã³ããã³ãã³ãªã©ã®ä¿æ¹¿å€ããã³ãã³ãä¹³
ç³ãã«ãªãªã³ããã³ããã€ããã³ãã€ãç¶ã±ã€é ž
ãªã©ã®åžçå€ã粟補ã¿ã«ã¯ãã¹ãã¢ãªã³é žå¡©ãã
ãŠé žæ«ãããªãšãã¬ã³ã°ãªã³ãŒã«ãªã©ã®æ»æ²¢å€ãª
ã©ãäŸç€ºã§ãããããã«é å€ã¯å¿ èŠã«å¿ãéåžžã®
å€ç®ãæœããé å€ãäŸãã°ç³è¡£é ããŒã©ãã³è¢«å
é ãè žæº¶è¢«é ããã€ã«ã ã³ãŒãã€ã³ã°é ãããã¯
äºéé ãå€å±€é ãšããããšãã§ãããäžžå€ã®åœ¢æ
ã«æ圢ããã«éããŠã¯ãæ äœãšããŠãã®åéã§åŸ
æ¥å ¬ç¥ã®ãã®ãåºã䜿çšã§ããäŸãã°ããããŠ
ç³ãä¹³ç³ããã³ãã³ãã«ã«ãªèã硬åæ€ç©æ²¹ãã«
ãªãªã³ãã¿ã«ã¯ãªã©ã®è³Šåœ¢å€ãã¢ã©ãã¢ãŽã æ«ã
ãã©ã¬ã³ãæ«ããŒã©ãã³ããšã¿ããŒã«ãªã©ã®çµå
å€ãã©ããã©ã³ãã«ã³ãã³ãªã©ã®åŽ©å£å€ãªã©ãäŸ
瀺ã§ãããåå€ã®åœ¢æ ã«æ圢ããã«éããŠã¯ãæ
äœãšããŠåŸæ¥å ¬ç¥ã®ãã®ãåºã䜿çšã§ããäŸãã°
ããªãšãã¬ã³ã°ãªã³ãŒã«ãã«ã«ãªèãé«çŽã¢ã«ã³
ãŒã«ãé«çŽã¢ã«ã³ãŒã«ã®ãšã¹ãã«é¡ããŒã©ãã³ã
ååæã°ãªã»ã©ã€ããªã©ãæããããšãã§ããã
泚å°å€ãšããŠèª¿è£œãããå Žåã«ã¯ã液å€ããã³æž
æ¿å€ã¯æ®ºèããããã€è¡æ¶²ãšç匵ã§ããã®ã奜ãŸ
ãããããã液å€ãä¹³å€ããã³æžæ¿å€ã®åœ¢æ ã«æ
圢ããã®ã«éããŠã¯ãçšéå€ãšããŠãã®åéã«ã
ããŠæ £çšãããŠãããã®ããã¹ãŠäœ¿çšã§ããäŸã
ã°æ°Žããšãã«ã¢ã«ã³ãŒã«ããããã¬ã³ã°ãªã³ãŒ
ã«ããšããã·åã€ãœã¹ãã¢ãªã«ã¢ã«ã³ãŒã«ãããª
ãªãã·åã€ãœã¹ãã¢ãªã«ã¢ã«ã³ãŒã«ãããªãªãã·
ãšãã¬ã³ãœã«ãã¿ã³èèªé žãšã¹ãã«é¡ãªã©ãæã
ãããšãã§ããããªãããã®å Žåç匵æ§ã®æº¶æ¶²ã
調補ããã«å åãªéã®é£å¡©ããããŠç³ãããã¯ã°
ãªã»ãªã³ãæ朰çå€äžã«å«æããããŠãããããŸ
ãéåžžã®æº¶è§£è£å©å€ãç·©è¡å€ãç¡çåå€ãªã©ãã
æŽã«å¿ èŠã«å¿ããŠçè²å€ãä¿åå€ãéŠæã颚å³
å€ãçå³å€ãªã©ãä»ã®å»è¬åã該治çå€äžã«å«æ
ããããŠãããã æ¬çºæã®æ朰çå€äžã«å«æãããã¹ãæ¬çºæã®
ååç©ã®éã¯ãšãã«éå®ãããåºç¯å²ã«éžæãã
ãããéåžžå šçµæç©äžïŒã70ééïŒ ã奜ãŸããã¯
ïŒã50ééïŒ ã§ããã æ¬çºæã®æ朰çå€ã®æäžæ¹æ³ã«ã¯ãšãã«å¶éã¯
ãªããå皮補å€åœ¢æ ãæ£è ã®å¹Žä»€ãæ§å¥ãã®ä»ã®
æ¡ä»¶ãçŸæ£ã®çšåºŠãªã©ã«å¿ããæ¹æ³ã§æäžãã
ããäŸãã°é å€ãäžžå€ã液å€ãæžæ¿å€ãä¹³å€ãé¡
ç²å€ããã³ã«ãã»ã«å€ã®å Žåã«ã¯çµå£æäžãã
ãããŸã泚å°å€ã®å Žåã«ã¯åç¬ã§ãããã¯ãããŠ
ç³ãã¢ããé žãªã©ã®éåžžã®è£æ¶²ãšæ··åããŠéèå
æäžãããããã«ã¯å¿ èŠã«å¿ããŠåç¬ã§çèå ã
ç®å ãç®äžãããã¯è ¹è å æäžããããåå€ã®å Ž
åã«ã¯çŽè žå æäžãããã æ¬çºæã®æ朰çå€ã®æäžéã¯çšæ³ãæ£è ã®å¹Ž
什ãæ§å¥ãã®ä»ã®æ¡ä»¶ãçŸæ£ã®çšåºŠãªã©ã«ããé©
å®éžæãããããéåžžæ¬çºæååç©ã®éã¯ïŒæ¥åœ
ãäœéïŒKgåœã0.6ã50mgãšããã®ãããããŸãã
æäžåäœåœ¢æ äžã«æå¹æåã10ã1000mgå«æãã
ããã®ãããã ã€ãã«åèäŸããã³å®æœäŸãæããŠæ¬çºæãã
ãã«å ·äœçã«èª¬æããããæ¬çºæã¯ãããã«éå®
ããããã®ã§ã¯ãªãã åèäŸ ïŒ ïœâã¢ããå®æ¯éŠé ž100ïœããšãŒãã«ïŒã«æž
æ¿ãã宀枩ãæ¹æäžãβâãšããã·ã¢ã¯ãªã«é žã¯
ãã©ã€ã44.6ïœã滎äžããããã®æ··åç©ã40âã§
ïŒæéåå¿åŸãæåºç©ãåãããçµæ¶ãïŒåæ°Ž
æŽã也ç¥ããã¡ã¿ããŒã«ããåçµæ¶ããŠç¡è²ç¶¿ç¶
æ¶ã®ïœâã«ã«ããã·ââïŒÎ²âãšããã·ã¢ã¯ãª
ãã€ã«ïŒã¢ããªã³60ïœãåŸããèç¹200.5ã202.0
â åèäŸ ïŒ ïŒâããšãã«ããããªã³é žã¡ãã«50ïœãã¯ãã
ã¢ã»ãã«ã¯ãã©ã€ã51.6ïœããã³ãžã¯ããã¡ã¿ã³
250mlã®æ··åç©ãïŒâã«å·åŽãããïŒã10âã§æ¹
æäžãå¡©åã¢ã«ãããŠã 122ïœãåŸã ã«å ããã
ãã®åŸå®€æž©ã§ïŒæéæ¹æããã宀枩ã§äžå€æŸçœ®
åŸãåå¿æ··åç©ãæ°·âæ¿å¡©é žäžã«æ³šããã¯ããã
ã«ã ã§æœåºãããã¯ãããã«ã å±€ãæ°ŽæŽã也ç¥ã
ãŠãã¯ãããã«ã ãçå»ãããæ®æž£ã«ã€ãœããã
ã«ãšãŒãã«ãå ããŠçµæ¶åããçµæ¶ãåãããš
ã¿ããŒã«ããåçµæ¶ããŠç¡è²éç¶æ¶ã®ïŒâïŒïŒâ
ã¯ããã¢ã»ãã«ããšãã«ïŒããããªã³é žã¡ãã«
53.4ïœãåŸããèç¹90.0ã92.0â åèäŸ ïŒ ïŒâïŒïŒâã¯ããã¢ã»ãã«ããšãã«ïŒããããª
ã³é žã¡ãã«36.26ïœãæ¿ç¡«é ž300mlã«æº¶è§£ããçºç
ç¡é žïŒïœïŒ1.52ïŒ20.9ïœãæ°·æ°Žå·äžæ¹æããªãã
滎äžããã宀枩ã§ïŒæéæ¹æããã®ã¡ãåå¿æ··å
ç©ãæ°·æ°Žäžã«æ³šããã¯ãããã«ã ã§æœåºãããã¯
ãããã«ã å±€ãæ°ŽæŽã也ç¥åŸãã¯ãããã«ã ãç
å»ãããæ®æž£ãã·ãªã«ã²ã«ã«ã©ã ã¯ãããã°ã©ã
ã€ã§ç²Ÿè£œãããšãŒãã«ãå ããŠçµæ¶åãããçµæ¶
ãåããã¡ã¿ããŒã«ããåçµæ¶ããŠæ·¡é»è²ããª
ãºã æ¶ã®ïŒâïŒïŒâã«ã«ããã·âïŒâãããããš
ãã«ïŒããããªã³é žã¡ãã«26.7ïœãåŸããèç¹
120.0ã122.0â åèäŸ ïŒ ã¯ããã¢ã»ãã«ã¯ãã©ã€ã467ïœã®ãžã¯ããã¡
ã¿ã³400ml溶液ã«30â以äžã§æ¹æäžãå¡©åã¢ã«ã
ããŠã 735ïœã1/3ã¥ã€å ããã次ã«å枩床ã»æ¹æ
äžã«ã«ãã¹ããªã«200ïœãå ããããã®æ··å液ã
ïŒæéå ç±éæµããã®ã¡ãåå¿æ··åç©ãæ°·âæ¿å¡©
é žäžã«æ³šããæåºããçµæ¶ãåããããããã¡
ã¿ããŒã«ãç±ã¡ã¿ããŒã«ã§æŽæµããŠïŒâã¯ããã¢
ã»ãã«ã«ã«ãã¹ããªã«153ïœãåŸããæ¯æ¶²ãæ¿çž®
也åºããæ®æž£ãã·ãªã«ã²ã«ã«ã©ã ã¯ãããã°ã©ã
ã€ã§ç²Ÿè£œããã¡ã¿ããŒã«ããåçµæ¶ããŠæ·¡é»è²é
ç¶æ¶ã®ïŒâã¯ããã¢ã»ãã«ã«ã«ãã¹ããªã«35.41
ïœãåŸããèç¹177.5ã179.0â åèäŸ ïŒ ïŒâã¯ããã¢ã»ãã«ã«ã«ãã¹ããªã«30ïœãšããª
ãžã³300mlãæ··åãã80ã90âã§2.5æéå ç±æ¹æ
ãããåå¿æ¶²ãæ°·æ°Žå·ããæåºããçµæ¶ãå
ãããšãŒãã«ã§æŽæµåŸãã¡ã¿ããŒã«ããåçµæ¶ã
ãŠç¡è²éç¶æ¶ã®ïŒâïŒÎ±âããªãžããŠã ã¢ã»ãã«ïŒ
ã«ã«ãã¹ããªã«ã¯ãã©ã€ã40.85ïœãåŸããèç¹
261.5ã264.0âïŒåè§£ïŒ åèäŸ ïŒ ïœâã¢ããå®æ¯éŠé žã¡ãã«29.5ïœã®ãžãšãã«ãš
ãŒãã«300ml溶液ã«ãæ¹æäž17ã27âã§Î²âãšã
ãã·ã¢ã¯ãªã«é žã¯ãã©ã€ã11.53ïœã滎äžããã
滎äžåŸã宀枩ã§ïŒæéæ¹æããæåºæ¶ãåã
ãããšãŒãã«æŽæµåŸãç²çµæ¶ãã¯ãããã«ã ã«æº¶
解ãã0.5Nå¡©é žã飜åçé žæ°ŽçŽ ãããªãŠã ã飜
åé£å¡©æ°Žã§æŽæµããã也ç¥åŸãã¯ãããã«ã ãç
å»ããæ®æž£ãã·ãªã«ã²ã«ã«ã©ã ã¯ãããã°ã©ãã€
ã§ç²Ÿè£œããã€ãã§ã¡ã¿ããŒã«ããåçµæ¶ããŠãç¡
è²ããªãºã ç¶æ¶ã®13.63ïœã®ïœâã¡ããã·ã«ã«ã
ãã«ââïŒÎ²âãšããã·ã¢ã¯ãªãã€ã«ïŒã¢ããª
ã³ãåŸããèç¹108ã110â åèäŸ ïŒ (a) ïŒâïŒÎ±âã¯ããã¢ã»ãã«ïŒã«ã«ãã¹ããªã«
60ïœãããªãžã³0.5Kgã«æžæ¿ãã80ã90âã§ïŒ
æéæ¹æããç¶ããŠæ°·å·äžïŒæéæ¹æãããæ
åºæ¶ãåããã¡ã¿ããŒã«ããåçµæ¶ããŠç¡è²
éç¶æ¶ã®ïŒâïŒÎ±âããªãžããŠã ã¢ã»ãã«ïŒã«
ã«ãã¹ããªã«ã¯ãã©ã€ã1/2æ°Žåç©70ïœãåŸãã
èç¹300âä»¥äž (b) ïŒâïŒÎ±âããªãžããŠã ã¢ã»ãã«ïŒã«ã«ãã¹
ããªã«ã¯ãã©ã€ã69.7ïœããã³æ°Žé žåãããªãŠ
ã 65ïœãæ°Ž0.6ã«æº¶è§£ãã60ã70âã§ïŒæé
æ¹æãããæ°·å·äžãåå¿æ··åç©ã«æ¿å¡©é žãå ã
ãŠãPHâïŒãšãããæåºæ¶ãåããDMFã
ãåçµæ¶ããŠæ·¡è¶è²ç²æ«ç¶æ¶ã®ïŒâã«ã«ããã·
ã«ã«ãã¹ããªã«41.4ïœãåŸããèç¹300âä»¥äž åèäŸ ïŒ åèäŸïŒãšåæ§ã«ããŠé©åœãªåºçºåæãçšããŠ
以äžã®ååç©ãåŸãã ïŒâã«ã«ããã·âïŒïŒïŒâãžãããã«ã«ãã¹ã
ãªã«ãæ·¡é»è²ç²æ«ç¶æ¶ïŒãžã¡ãã«ãã«ã ã¢ããïŒ
èç¹300âä»¥äž ïŒâã«ã«ããã·ã«ã«ãã¹ããªã«ãç¡è²éç¶æ¶
ïŒã¡ã¿ããŒã«âã¯ãããã«ã ïŒãèç¹320â以äžã
NMRïŒDMSOïŒÎŽ6.57ïŒd.JïŒ9.5Hzã1HïŒã7.25
ïŒïœïŒïŒªïŒ8.0Hzã1HïŒã7.94ïŒïœïŒïœïŒïŒªïŒ8.0Hzã
1.5Hzã1HïŒã7.98ïŒïœïŒïŒªïŒ9.5Hzã1HïŒã8.14
ïŒïœïŒïœïŒïŒªïŒ8.0Hzã1.5Hzã1HïŒ åèäŸ ïŒ ïŒâã«ã«ããã·âïŒïŒïŒâãžãããã«ã«ãã¹ã
ãªã«10ïœããã³ïŒ®âããããã·ã³ãã¯é žã€ãã
6.0ïœããžãªããµã³200mlã«æžæ¿ããããã€ãã«æ°·
å·æ¹æäžããžã·ã¯ãããã·ã«ã«ã«ããžã€ãã12.4
ïœã®50mlãžãªããµã³æº¶æ¶²ã滎äžããããã®æ··å液
ã90âã§ïŒæéå ç±æ¹æãããåå¿çµäºåŸã宀枩
ãŸã§æŸå·ããæåºæ¶ãå»ãã液ãæ¿çž®ä¹Ÿåº
ãããã®æ®æž£ããžã¡ãã«ãã«ã ã¢ããâãšã¿ããŒ
ã«ããåçµæ¶ããŠç¡è²ãªã³çç¶æ¶ã®ã³ãã¯é žã€ã
ãïŒïŒïŒâãžãããã«ã«ãã¹ããªã«âïŒâã«ã«ã
ãã·ã¬ãŒã10.8ïœãåŸããèç¹234.5ã236â åèäŸ 10 ïœâã«ã«ããã·ââïŒÎ²âãšããã·ã¢ã¯ãªã
ã€ã«ïŒã¢ããªã³ïŒïœãæ¿ç¡«é ž80mlã«å ãã宀枩ã§
ïŒæéãç¶ããŠ50âã§ïŒæéæ¹æãããåå¿æ¶²ã
æ°·äžã«æ³šãã10Næ°Žé žåãããªãŠã 氎溶液ã§PHïŒ
ãïŒã«èª¿æŽãããæåºæ¶ãåããæ°ŽæŽããŠ
DMFããåçµæ¶ããŠæ·¡é»è²ç²æ«ç¶æ¶ã®ïŒâã«ã«
ããã·ã«ã«ãã¹ãã«4.26ïœãåŸããèç¹320â以
äž NMRïŒDMSOïŒÎŽ6.58ïŒd.JïŒ9.5Hzã1HïŒã7.40
ã7.80ïŒïœïŒ3HïŒã8.69ïŒïœïŒïŒªïŒ9.5Hzã1HïŒ åèäŸ 11 ïŒâïŒïŒâã«ã«ããã·âïŒâãããããšãã«ïŒ
ããããªã³é žã¡ãã«ïŒïœã2.226Næ°Žé žåãããª
ãŠã ã¡ã¿ããŒã«æº¶æ¶²8.87mlãã¡ã¿ããŒã«100mlã
ãã³ïŒïŒ PdâïŒ50ïŒ å«æ°ŽïŒïŒïœãæ··åããåžž
æž©ãåžžå§ã§æ¥è§Šéå ããã觊åªãå»ããæ¯æ¶²ã«
æ¿å¡©é žãå ãPHâïŒã«èª¿æŽããæåºããçµæ¶ã
åããç¡è²éç¶æ¶ã®ã¡ã¿ããŒã«ããåçµæ¶ããŠã
ïŒâã«ã«ããã·âïŒïŒïŒâãžãããã«ã«ãã¹ããª
ã«3.62ïœãåŸããèç¹320âä»¥äž NMRïŒDMSOïŒÎŽ2.33ã2.60ïŒïœã2HïŒã2.77ã
3.05ïŒïœïŒ2HïŒã7.21ïŒïœïŒïŒªïŒ8.5Hzã1HïŒã7.38
ã7.53ïŒïœã2HïŒã10.15ïŒïœã1HïŒ åèäŸ 12 ïœâã¡ããã·ã«ã«ããã«ââïŒÎ²âãšããã·
ã¢ã¯ãã€ã«ïŒã¢ããªã³10ïœãæ¿ç¡«é ž100mläžã«
åŸã ã«å ãã宀枩ã§ïŒæéã45âã§ïŒæéæ¹æã
ããåå¿æ¶²ãæ°·äžã«æ³šããæåºæ¶ãåãæ°ŽæŽã
ããåŸãããç²çµæ¶ãã¡ã¿ããŒã«âã¯ãããã«ã
ã§åçµæ¶ããŠã6.97ïœã®ïŒâã¡ããã·ã«ã«ããã«
ã«ã«ãã¹ããªã«ãåŸããèç¹277.5ã279.0â åèäŸ 13 ïŒâã«ã«ããã·ã«ã«ãã¹ããªã«ïŒïœãæ°Ž30mlã«
æžæ¿ããããã«10Næ°Žé žåãããªãŠã 氎溶液ãå
ããŠçµæ¶ã溶解ããã溶液ã«10ïŒ PtâC500mgã
å ããŠãæ°ŽçŽ å§ïŒãïŒKgïŒcm2ã70âã§æ¥è§Šéå ã
ããåå¿åŸã觊åªãå»ãã液ã«æ¿å¡©é žãå ã
ãŠãPHâïŒãšããæåºæ¶ãåããã¡ã¿ããŒã«ã
ãåçµæ¶ããŠç¡è²éç¶æ¶ã®ïŒâã«ã«ããã·âïŒïŒ
ïŒâãžãããã«ã«ãã¹ããªã«820mgãåŸããèç¹
309ã311â åèäŸ 14 ïŒâã«ã«ããã·ã«ã«ãã¹ããªã«ïŒïœãã¡ã¿ããŒ
ã«100mlã«æžæ¿ããå¡©é žã¬ã¹ãããã«ããŠé£œåã
ãã®ã¡ãïŒæééæµãããåå¿æ¶²ãåéã«ãªããŸ
ã§æ¿çž®ããæåºããçµæ¶ãåãããã·ãªã«ã²ã«
ã«ã©ã ã¯ãããã°ã©ãã€ã§ç²Ÿè£œãã次ãã§ã¡ã¿ã
ãŒã«âã¯ãããã«ã ããåçµæ¶ããŠç¡è²ç²æ«ç¶æ¶
ã®ïŒâã¡ããã·ã«ã«ããã«ã«ã«ãã¹ããªã«230mg
ãåŸããèç¹277.5ã279â åèäŸ 15 ïŒâïŒÎ±âããªãžããŠã ã¢ã»ãã«ïŒã«ã«ãã¹ã
ãªã«ã¯ãã©ã€ãïŒïœãã¡ã¿ããŒã«20mlã«æº¶è§£ãã
ããã«1.01ïœã®DBUãå ããïŒæééæµããã
åå¿æ¶²ãæ¿çž®ä¹Ÿåºããæ®æž£ã«æ°Žãã¯ãããã«ã ã
1Nå¡©é žãå ãããã¯ãããã«ã å±€ãæ°Žã飜åç
é žæ°ŽçŽ ãããªãŠã 氎溶液ã飜åé£å¡©æ°Žã®é ã«æŽæµ
åŸã也ç¥ãããã¯ãããã«ã ãçå»ããåŸããã
æ®æž£ãã·ãªã«ã²ã«ã«ã©ã ã¯ãããã°ã©ãã€ã§ç²Ÿè£œ
ããã€ãã§ã¡ã¿ããŒã«ããåçµæ¶ããŠç¡è²éç¶æ¶
ã®ïŒâã¡ããã·ã«ã«ããã«ã«ã«ãã¹ããªã«130mg
ãåŸããèç¹140ã142â åèäŸ 16 ïŒâãã«ãã«ã«ã«ãã¹ããªã«34ïœãã¡ã¿ããŒã«
800mlã«æžæ¿ãããæ°·å·æ¹æäžãæ°ŽçŽ åããŠçŽ ã
ããªãŠã 7.4ïœãå°éãã€æ·»å ãããæ°·å·äžãïŒ
æéæ¹æãè¡ãªããæåºæ¶ãåããã¡ã¿ããŒã«
ããåçµæ¶ããŠç¡è²ããªãºã ç¶ã®ïŒâããããã·
ã¡ãã«ã«ã«ãã¹ããªã«33.2ïœãåŸããèç¹238ã
239.5â åèäŸ 17 æ°ŽçŽ åãªããŠã ã¢ã«ãããŠã 16ïœã也ç¥ããã©
ããããã©ã³200mlã«æžæ¿ããã宀枩ã§æ¹æããª
ããïŒâã¡ããã·ã«ã«ããã«ã«ã«ãã¹ããªã«16ïœ
ãæ·»å ããã宀枩ã§ïŒæéæ¹æãããé ¢é žãšãã«
ã滎äžããéå°ã®æ°ŽçŽ åãªããŠã ã¢ã«ãããŠã ã
å解ãããããã«æ°Žãå ããã®ã¡ãæžå§æ¿çž®ã
ããæ®æž£ã«åžç¡«é žãå ããæåºæ¶ãåããã¡ã¿
ããŒã«ããåçµæ¶ããŠç¡è²ããªãºã ç¶ã®ïŒâãã
ããã·ã¡ãã«ã«ã«ãã¹ããªã«3.7ïœãåŸããèç¹
238ã239.5â åèäŸ 18ã22a åèäŸ16ããã³17ãšåæ§ã«ããŠé©åœãªåºçºåæ
ãçšããŠæ¬¡è¡šã®ååç©ãåŸãã
ç©ïŒã«å°ãåå¿ã¯ãåèšåå¿åŒâXIã«ãããåå
ç©13ãååç©ïŒïŒã«éå ããå Žåãšåæ§ã®éå æ¡
件äžããªãã³ã«åèšåå¿åŒâã«ãããååç©
ïŒâ²ãååç©ïŒâ³ã«å°ãå Žåã®æ¥è§Šéå æ³ãšåæ§ã®
æ¡ä»¶äžã«è¡ãªãããã ååç©ïŒãããã«éå ããŠååç©ïŒïŒã«å°ãæ¹
æ³ã¯ãçš®ã ã®æ¹æ³ãããããäŸãã°æ°ŽçŽ åéå å€
ãçšããéå æ³ã奜é©ã«å©çšããããçšãããã
æ°ŽçŽ åéå å€ãšããŠã¯ãäŸãã°æ°ŽçŽ åã¢ã«ãããŠ
ã ãããªãŠã ãæ°ŽçŽ åããªâtertâãããã·ã¢ã«
ãããŠã ãªããŠã ãæ°ŽçŽ åãžã€ãœããã«ã¢ã«ãã
ãŠã ãæ°ŽçŽ åïŒïŒïŒïŒâãžã¡ãã«âïŒâãžã€ãœã
ããã«ã¡ãã«ïŒããŠçŽ ãïŒïœâC3H7ïŒ
ïŒCH3ïŒ2CBH2ããªã©ãæãããããã®äœ¿çšéã¯ã
éåžžãååç©ïŒã«å¯ŸããŠçééã§ããããã®éå
åå¿ã¯ãäŸãã°ãžãšãã«ãšãŒãã«ãããã©ããã
ãã©ã³ããžã°ã©ã€ã ãªã©ã®é©åœãªæº¶åªäžãéåžžã
â60ã50âçšåºŠã奜ãŸããã¯â30âã宀枩ã«ãŠè¡
ãªããã10åéãïŒæéã§çµäºããã K0042 ãåŒäžãR2ïŒïŒ¡ïŒïœããã³ïŒžã¯åèšã«åãã äžèšåå¿åŒã«ãããååç©ïŒïŒã®éç°åå¿ã¯ã
åèšåå¿åŒâã«ãããååç©11ã®éç°åå¿ãšå
æ§ã®æ¡ä»¶äžã«è¡ãªããããŸãååç©ïŒïŒããåå
ç©9bã«å°ãåå¿ãåèšåå¿åŒâã«ãããåå
ç©12ããååç©6aãããåå¿ãšåãæ¡ä»¶äžã«è¡
ãªãããã K0043 ãåŒäžãR2ããã³ã¯åèšã«åãã äžèšåå¿åŒã«ãããŠãååç©37ã®ããã²ã³åå
å¿ã¯ãé©åœãªæº¶åªäžååç©37ãããã²ã³åå€ã§åŠ
çããŠè¡ãªããããçšããããããã²ã³åå€ãšã
ãŠã¯äŸãã°å¡©çŽ ãèçŽ ãªã©ã®ããã²ã³ååãâ
ããã¢ã³ãã¯é žã€ãããâã¯ããã³ãã¯é žã€ã
ããªã©ã®ïŒ®âããã²ãã³ãã¯é žã€ãããå¡©åã¹ã«
ããªã«ãå¡©åé ãèåé ãªã©ã®ããã²ã³åé ãªã©
ãæããããã溶åªãšããŠã¯ãžã¯ããã¡ã¿ã³ããž
ã¯ãããšã¿ã³ãã¯ãããã«ã ãåå¡©åççŽ ãªã©ã®
ããã²ã³åçåæ°ŽçŽ é¡ããžãšãã«ãšãŒãã«ããã
ã©ããããã©ã³ããžãªããµã³ãªã©ã®ãšãŒãã«é¡ã
é ¢é žãªã©ãäŸç€ºã§ããããã®ããã²ã³åå€ã®äœ¿çš
éã¯ãååç©37ã«å¯ŸããŠçã¢ã«ãéå°éã奜ãŸã
ãã¯çã¢ã«ã1.2åã¢ã«ã§ããã該åå¿ã¯éåžžïŒ
âã溶åªã®æ²žç¹ä»è¿ã奜ãŸããã¯å®€æž©ã40âã§ã
ããéåžžïŒã10æéçšåºŠã§çµäºããããªãããã®
åå¿ã«éé žåãã³ãŸã€ã«ãéé žåæ°ŽçŽ ãªã©ã®éé ž
åç©ã®ãããªã©ãžã«ã«åå¿éå§å€ãçšããŠãã
ãã ååç©38ãéç°ãããŠååç©9cã«å°ãåå¿ã¯é©
åœãªæº¶åªäžçž®åå€ã®ååšäžã«è¡ãªããããçšãã
ããçž®åå€ãšããŠã¯ãäŸãã°äºé žåãªã³ãããå
æ°ŽçŽ ãç¡«é žãããªãªã³é žãå¡©åã¢ã«ãããŠã ãå¡©
åäºéãªã©ã®ã«ã€ã¹é žãªã©ãæããããã溶åªãš
ããŠã¯ã¯ãããã«ã ããžã¯ããã¡ã¿ã³ãïŒïŒïŒâ
ãžã¯ãããšã¿ã³ãªã©ã®ããã²ã³åçåæ°ŽçŽ é¡ããž
ãšãã«ãšãŒãã«ããžãªããµã³ãªã©ã®ãšãŒãã«é¡ã
ããããã³ãŒã³ãã¯ãããã³ãŒã³ãªã©ã®è³éŠæç
åæ°ŽçŽ é¡ãªã©ãäŸç€ºã§ãããååç©38ãšçž®åå€ãš
ã®äœ¿çšå²åã¯ç¹ã«éå®ãããªãããéåžžãåè ã«
察ããŠåŸè ãçã¢ã«ã10åã¢ã«ã奜ãŸããã¯ïŒã
ïŒåã¢ã«ãšããã®ãããããã®åå¿ã¯ãéåžžã50
ã250âã奜ãŸããã¯70ã200âã«ãŠ20åãïŒæé
çšåºŠè¡ãªãããã K0044 ãåŒäžãR1ïŒR2ïŒïŒžïŒïŒ¡ïŒïœããã³ã«ã«ãã¹
ããªã«éªšæ žã®ïŒäœãšïŒäœéã®çµåã¯åèšã«åãã
R15ã¯äœçŽã¢ã«ã«ãã€ã«ã瀺ãã äžèšåå¿åŒã«ãããååç©ïŒãšååç©39ãšã®å
å¿ã¯ã奜ãŸããã¯å¡©åºæ§ååç©ãè±ããã²ã³åæ°Ž
çŽ å€ãšããŠçšããé©åœãªæº¶åªäžã宀枩ã200âã
奜ãŸããã¯å®€æž©ã150âã«ãŠæ°æéã15æéçšåºŠ
è¡ãªããããçšãããã溶åªãšããŠã¯ãäŸãã°ã¡
ã¿ããŒã«ããšã¿ããŒã«ãã€ãœãããããŒã«ãªã©ã®
äœçŽã¢ã«ã³ãŒã«é¡ããžãšãã«ãšãŒãã«ãããã©ã
ãããã©ã³ããžãªããµã³ããšãã¬ã³ã°ãªã³ãŒã«ã¢
ãã¡ãã«ãšãŒãã«ããžãšãã¬ã³ã°ãªã³ãŒã«ãžã¡ã
ã«ãšãŒãã«ãªã©ã®ãšãŒãã«é¡ããã³ãŒã³ããã«ãš
ã³ããã·ã¬ã³ãªã©ã®è³éŠæçåæ°ŽçŽ é¡ãã¢ã»ã
ã³ãã¡ãã«ãšãã«ã±ãã³ãªã©ã®ã±ãã³é¡ããžã¡ã
ã«ãã«ã ã¢ããããžã¡ãã«ã¹ã«ããã·ãããããµ
ã¡ãã«ããªã³é žããªã¢ãããç¡æ°Žé ¢é žãªã©ãæã
ããããå¡©åºæ§ååç©ãšããŠã¯ãäŸãã°æ°Žé žåã
ããªãŠã ãæ°Žé žåã«ãªãŠã ãçé žãããªãŠã ãç
é žã«ãªãŠã ãçé žæ°ŽçŽ ãããªãŠã ãçé žæ°ŽçŽ ã«ãª
ãŠã ãçé žéãªã©ã®ç¡æ©å¡©åºããããªãŠã ãã«ãª
ãŠã ãªã©ã®ã¢ã«ã«ãªéå±ããããªãŠã ã¢ãããæ°Ž
çŽ åãããªãŠã ããããªãŠã ã¡ãã©ãŒãããããª
ãŠã ãšãã©ãŒããã«ãªãŠã ãšãã©ãŒããªã©ã®ã¢ã«
ã³ã©ãŒããããªãšãã«ã¢ãã³ãããªãããã«ã¢ã
ã³ãããªãžã³ããããªã³ãïŒïŒ®âãžã¡ãã«ã¢ã
ãªã³ãâã¡ãã«ã¢ã«ããªã³ãªã©ã®ç¬¬äžçŽã¢ãã³
é¡ãæãããããäžèšåå¿ã«ãããŠåå¿ä¿é²å€ãš
ããŠãšãŠåã«ãªãŠã ããšãŠåãããªãŠã ãªã©ã®ãš
ãŠåã¢ã«ã«ãªéå±ãçšããŠããããååç©ïŒãšå
åç©39ãšã®äœ¿çšå²åã¯ç¹ã«å¶éãããªãããé
åžžãåè ã«å¯ŸããŠåŸè ãå°ãªããšãçã¢ã«ã奜ãŸ
ããã¯ïŒãïŒã¢ã«çšåºŠã§ããã ããããååç©40ãå æ°Žå解ããã°ååç©ïŒïŒ
ã«å°ãããããã®å æ°Žå解åå¿ã¯ãäŸãã°å¡©é žã
èåæ°ŽçŽ é žãªã©ã®ããã²ã³åæ°ŽçŽ é žé¡ãç¡«é žããª
ã³é žãªã©ã®é±é žé¡ãæ°Žé žåã«ãªãŠã ãæ°Žé žåãã
ãªãŠã ãªã©ã®ã¢ã«ã«ãªéå±æ°Žé žåç©ãçé žãããª
ãŠã ãçé žã«ãªãŠã ãçé žæ°ŽçŽ ãããªãŠã ãªã©ã®
ã¢ã«ã«ãªéå±çé žå¡©ãŸãã¯éçé žå¡©ãªã©ã®ååšäž
ã«ãéåžžã50ã150âã奜ãŸããã¯70ã100âã«ãŠ
ïŒã24æéçšåºŠå ç±åå¿ããããšã«ããè¡ãªãã
ãã ãªãããããååç©ïŒããã³ïŒïŒã¯ãåèšåå¿
åŒâããã³ã«ç€ºãããâã¢ã«ãã«åæ³ãªã
ã³ã«åå¿åŒâããã³ã«ç€ºãããè±æ°ŽçŽ åå¿ãŸ
ãã¯éå åå¿ãå©çšããæ¹æ³ãªã©ã«ãããåæ§ã«
ä»ã®åŒ(9)ãŸãã¯ïŒ16ïŒã®ååç©ã«å°ãããšãã§ã
ãã åèšåå¿åŒâXIã®ååç©13ã¯ãäŸãã°ãäžèšå
å¿åŒâXIIã®æ¹æ³ã«ãã€ãŠã補é ãããã K0045 K0046 ãåŒäžãR1ïŒR2ïŒïŒ¡ããã³ã«ã«ãã¹ããªã«éªš
æ žã®ïŒäœãšïŒäœã®çµåã¯åèšã«åããR16ã¯äœçŽ
ã¢ã«ãã«åºãnâ²ã¯ïŒã瀺ãã ååç©ïŒïŒãšååç©ïŒïŒãšã®åå¿ã¯ãåèšåå¿
åŒâã«ãããååç©ïŒãšååç©10ãšã®åå¿ãšå
æ§ã®æ¡ä»¶äžã«è¡ãªããããååç©ïŒïŒã®å æ°Žå解
åå¿ã¯ãåèšåå¿åŒâã«ãããååç©ïŒã®å æ°Ž
å解åå¿ãšåæ§ã®æ¡ä»¶äžã§è¡ãªãããã ååç©ïŒïŒãšããŠã¯ãäŸãã°ã·ã¢ã³åã«ãªãŠ
ã ãã·ã¢ã³åãããªãŠã ãã·ã¢ã³åéãã·ã¢ã³å
é ãã·ã¢ã³åã«ã«ã·ãŠã ãªã©ãæãããããåå
ç©ïŒïŒãšååç©ïŒïŒãšã®åå¿ã¯ãé©åœãªæº¶åªäžã§
è¡ãªããããçšãããã溶åªãšããŠã¯ãäŸãã°
æ°Žãã¡ã¿ããŒã«ããšã¿ããŒã«ãã€ãœãããããŒã«
ãªã©ã®äœçŽã¢ã«ã«ããŒã«é¡ããŸãã¯æ°ŽãšäœçŽã¢ã«
ã«ããŒã«é¡ãšã®æ··å溶åªãæãããããååç©ïŒ
ïŒã®äœ¿çšéã¯ãååç©ïŒïŒã«å¯ŸããŠå°ãªããšãç
ã¢ã«ã奜ãŸããã¯ïŒã1.5åã¢ã«ã§ããã該åå¿
ã¯é垞宀枩ã150âã奜ãŸããã¯50ã120âä»è¿
ã§ã30åã10æéçšåºŠè¡ãªãããã ãŸãååç©ïŒïŒã®å æ°Žå解åå¿ãäžèšååç©ïŒ
ã®å æ°Žå解åå¿ãšåæ§ã®æ¡ä»¶äžã«è¡ãªãããã ãŸãååç©13â²ã®ææã®ççŽ æ°ã®ãã®ã¯ãåèš
åå¿åŒâXIã®åå¿ããã³åå¿åŒâXIIã®åå¿ã®å¢
ççŽ åå¿ãé©å®çµåããŠç¹°è¿ãããšã«ããåŸãã
ãã æ¬çºæã®ååç©ïŒã¯ãŸãäžèšã®åå¿åŒã®
æ¹æ³ã«ãã€ãŠã補é ãããã K0047 K0048 ãåŒäžãR1ïŒR2ïŒR4â²ïŒR16ïŒïŒ¡ïŒnâ²ïŒïŒžïŒ
Xâ²ããã³ã«ã«ãã¹ããªã«éªšæ žã®ïŒäœããã³ïŒäœ
ã®çµåã¯åèšã«åãã ååç©41ãšååç©46ã®åå¿ã¯ãåèšåå¿åŒâ
ã«ãããååç©ïŒãšååç©10ãšã®åå¿ãšåæ§ã®æ¡
件äžã§è¡ãªããããååç©47ã®å æ°Žå解åå¿ã¯å
èšåå¿åŒâã«ãããååç©ïŒã®å æ°Žå解åå¿ãš
åæ§ã®æ¡ä»¶äžã«è¡ãªãããã ååç©48ãšååç©49ãšã®åå¿ã¯æº¶åªäžãŸãã¯ç¡
溶åªã§ãå¡©åºæ§ååç©ã®ååšäžã«è¡ãªããããçš
ãããã溶åªãšããŠã¯ããžãªããµã³ãããã©ãã
ããã©ã³ããšãã¬ã³ã°ãªã³ãŒã«ããžã¡ãã«ãšãŒã
ã«ããžãšãã«ãšãŒãã«ãªã©ã®ãšãŒãã«é¡ããã³ãŒ
ã³ããã«ãšã³ããã·ã¬ã³ãªã©ã®è³éŠæçåæ°ŽçŽ
é¡ãã¡ã¿ããŒã«ããšã¿ããŒã«ãã€ãœãããããŒã«
ãªã©ã®ã¢ã«ã³ãŒã«é¡ããžã¡ãã«ãã«ã ã¢ããããž
ã¡ãã«ã¹ã«ããã·ãããããµã¡ãã«ãªã³é žããªã¢
ãããã¢ã»ãã³ãªã©ã®æ¥µæ§æº¶åªãªã©ãæããã
ãã䜿çšãããå¡©åºæ§è§ŠåªãšããŠã¯ãçé žã«ãªãŠ
ã ãçé žãããªãŠã ãæ°Žé žåãããªãŠã ãæ°Žé žå
ã«ãªãŠã ãçé žæ°ŽçŽ ãããªãŠã ãçé žæ°ŽçŽ ã«ãªãŠ
ã ããããªãŠã ã¢ãããæ°ŽçŽ åãããªãŠã ãªã©ã®
ç¡æ©å¡©åºãããªãšãã«ã¢ãã³ãããªãããã«ã¢ã
ã³ãããªãžã³ããããªã³ãªã©ã®ææ©å¡©åºãæãã
ããã該åå¿ã¯é垞宀枩ã200âã奜ãŸããã¯å®€
æž©ã150âã§ãïŒã30æéçšåºŠè¡ãªãããããŸã
åå¿ç³»ã«ãšãŠåã«ãªãŠã ãŸãã¯ãšãŠåãããªãŠã
ãªã©ã®ã¢ã«ã«ãªéå±ãšãŠåç©ããããµã¡ãã«ãªã³
é žããªã¢ãããªã©ãå ããããšã«ããåå¿ã容æ
ã«é²è¡ãããäžèšåå¿ã«ãããååç©49ã®äœ¿çšå²
åã¯ãååç©48ã«å¯ŸããŠãéåžžãçã¢ã«ã倧éå°
éã奜ãŸããã¯çã¢ã«ãïŒåã¢ã«ã§ããã æ¬çºæååç©ã¯æ朰çå€ãšããŠæçšã§ãããé
åžžãäžè¬çãªå»è¬è£œå€ã®åœ¢æ ã§çšããããã補å€
ã¯é垞䜿çšãããå å¡«å€ãå¢éå€ãçµåå€ãä»æ¹¿
å€ã厩å£å€ãè¡šé¢æŽ»æ§å€ãæ»æ²¢å€ãªã©ã®çšéå€ã
ããã¯è³Šåœ¢å€ãçšããŠèª¿è£œãããããã®å»è¬è£œå€
ãšããŠã¯åçš®ã®åœ¢æ ãæ²»çç®çã«å¿ããŠéžæã§
ãããã®ä»£è¡šçãªãã®ãšããŠé å€ãäžžå€ãæ£å€ã
液å€ãæžæ¿å€ãä¹³å€ãé¡ç²å€ãã«ãã»ã«å€ãå
å€ã泚å°å€ïŒæ¶²å€ãæžæ¿å€çïŒãªã©ãæããã
ããé å€ã®åœ¢æ ã«æ圢ããã«éããŠã¯ãæ äœãšã
ãŠãã®åéã§åŸæ¥å ¬ç¥ã®ãã®ãåºã䜿çšã§ããäŸ
ãã°ä¹³ç³ãçœç³ãå¡©åãããªãŠã ããããŠç³ãå°¿
çŽ ããã³ãã³ãçé žã«ã«ã·ãŠã ãã«ãªãªã³ãçµæ¶
ã»ã«ããŒã¹ãã±ã€é žãªã©ã®è³Šåœ¢å€ãæ°Žããšã¿ããŒ
ã«ããããããŒã«ãåã·ãããããããŠç³æ¶²ãã
ã³ãã³æ¶²ããŒã©ãã³æº¶æ¶²ãã«ã«ããã·ã¡ãã«ã»ã«
ããŒã¹ãã»ã©ãã¯ãã¡ãã«ã»ã«ããŒã¹ããªã³é žã«
ãªãŠã ãããªããã«ãããªãã³ãªã©ã®çµåå€ã也
ç¥ãã³ãã³ãã¢ã«ã®ã³é žãããªãŠã ãã«ã³ãã³
æ«ãã©ããã©ã³æ«ãçé žæ°ŽçŽ ãããªãŠã ãçé žã«
ã«ã·ãŠã ãããªãªãã·ãšãã¬ã³ãœã«ãã¿ã³èèªé ž
ãšã¹ãã«é¡ãã©ãŠãªã«ç¡«é žãããªãŠã ãã¹ãã¢ãª
ã³é žã¢ãã°ãªã»ãªãããã³ãã³ãä¹³ç³ãªã©ã®åŽ©å£
å€ãçœç³ãã¹ãã¢ãªã³ãã«ã«ãªãã¿ãŒãæ°ŽçŽ æ·»å
æ²¹ãªã©ã®åŽ©å£æå¶å€ã第åçŽã¢ã³ã¢ããŠã å¡©åºã
ã©ãŠãªã«ç¡«é žãããªãŠã ãªã©ã®åžåä¿é²å€ãã°ãª
ã»ãªã³ããã³ãã³ãªã©ã®ä¿æ¹¿å€ããã³ãã³ãä¹³
ç³ãã«ãªãªã³ããã³ããã€ããã³ãã€ãç¶ã±ã€é ž
ãªã©ã®åžçå€ã粟補ã¿ã«ã¯ãã¹ãã¢ãªã³é žå¡©ãã
ãŠé žæ«ãããªãšãã¬ã³ã°ãªã³ãŒã«ãªã©ã®æ»æ²¢å€ãª
ã©ãäŸç€ºã§ãããããã«é å€ã¯å¿ èŠã«å¿ãéåžžã®
å€ç®ãæœããé å€ãäŸãã°ç³è¡£é ããŒã©ãã³è¢«å
é ãè žæº¶è¢«é ããã€ã«ã ã³ãŒãã€ã³ã°é ãããã¯
äºéé ãå€å±€é ãšããããšãã§ãããäžžå€ã®åœ¢æ
ã«æ圢ããã«éããŠã¯ãæ äœãšããŠãã®åéã§åŸ
æ¥å ¬ç¥ã®ãã®ãåºã䜿çšã§ããäŸãã°ããããŠ
ç³ãä¹³ç³ããã³ãã³ãã«ã«ãªèã硬åæ€ç©æ²¹ãã«
ãªãªã³ãã¿ã«ã¯ãªã©ã®è³Šåœ¢å€ãã¢ã©ãã¢ãŽã æ«ã
ãã©ã¬ã³ãæ«ããŒã©ãã³ããšã¿ããŒã«ãªã©ã®çµå
å€ãã©ããã©ã³ãã«ã³ãã³ãªã©ã®åŽ©å£å€ãªã©ãäŸ
瀺ã§ãããåå€ã®åœ¢æ ã«æ圢ããã«éããŠã¯ãæ
äœãšããŠåŸæ¥å ¬ç¥ã®ãã®ãåºã䜿çšã§ããäŸãã°
ããªãšãã¬ã³ã°ãªã³ãŒã«ãã«ã«ãªèãé«çŽã¢ã«ã³
ãŒã«ãé«çŽã¢ã«ã³ãŒã«ã®ãšã¹ãã«é¡ããŒã©ãã³ã
ååæã°ãªã»ã©ã€ããªã©ãæããããšãã§ããã
泚å°å€ãšããŠèª¿è£œãããå Žåã«ã¯ã液å€ããã³æž
æ¿å€ã¯æ®ºèããããã€è¡æ¶²ãšç匵ã§ããã®ã奜ãŸ
ãããããã液å€ãä¹³å€ããã³æžæ¿å€ã®åœ¢æ ã«æ
圢ããã®ã«éããŠã¯ãçšéå€ãšããŠãã®åéã«ã
ããŠæ £çšãããŠãããã®ããã¹ãŠäœ¿çšã§ããäŸã
ã°æ°Žããšãã«ã¢ã«ã³ãŒã«ããããã¬ã³ã°ãªã³ãŒ
ã«ããšããã·åã€ãœã¹ãã¢ãªã«ã¢ã«ã³ãŒã«ãããª
ãªãã·åã€ãœã¹ãã¢ãªã«ã¢ã«ã³ãŒã«ãããªãªãã·
ãšãã¬ã³ãœã«ãã¿ã³èèªé žãšã¹ãã«é¡ãªã©ãæã
ãããšãã§ããããªãããã®å Žåç匵æ§ã®æº¶æ¶²ã
調補ããã«å åãªéã®é£å¡©ããããŠç³ãããã¯ã°
ãªã»ãªã³ãæ朰çå€äžã«å«æããããŠãããããŸ
ãéåžžã®æº¶è§£è£å©å€ãç·©è¡å€ãç¡çåå€ãªã©ãã
æŽã«å¿ èŠã«å¿ããŠçè²å€ãä¿åå€ãéŠæã颚å³
å€ãçå³å€ãªã©ãä»ã®å»è¬åã該治çå€äžã«å«æ
ããããŠãããã æ¬çºæã®æ朰çå€äžã«å«æãããã¹ãæ¬çºæã®
ååç©ã®éã¯ãšãã«éå®ãããåºç¯å²ã«éžæãã
ãããéåžžå šçµæç©äžïŒã70ééïŒ ã奜ãŸããã¯
ïŒã50ééïŒ ã§ããã æ¬çºæã®æ朰çå€ã®æäžæ¹æ³ã«ã¯ãšãã«å¶éã¯
ãªããå皮補å€åœ¢æ ãæ£è ã®å¹Žä»€ãæ§å¥ãã®ä»ã®
æ¡ä»¶ãçŸæ£ã®çšåºŠãªã©ã«å¿ããæ¹æ³ã§æäžãã
ããäŸãã°é å€ãäžžå€ã液å€ãæžæ¿å€ãä¹³å€ãé¡
ç²å€ããã³ã«ãã»ã«å€ã®å Žåã«ã¯çµå£æäžãã
ãããŸã泚å°å€ã®å Žåã«ã¯åç¬ã§ãããã¯ãããŠ
ç³ãã¢ããé žãªã©ã®éåžžã®è£æ¶²ãšæ··åããŠéèå
æäžãããããã«ã¯å¿ èŠã«å¿ããŠåç¬ã§çèå ã
ç®å ãç®äžãããã¯è ¹è å æäžããããåå€ã®å Ž
åã«ã¯çŽè žå æäžãããã æ¬çºæã®æ朰çå€ã®æäžéã¯çšæ³ãæ£è ã®å¹Ž
什ãæ§å¥ãã®ä»ã®æ¡ä»¶ãçŸæ£ã®çšåºŠãªã©ã«ããé©
å®éžæãããããéåžžæ¬çºæååç©ã®éã¯ïŒæ¥åœ
ãäœéïŒKgåœã0.6ã50mgãšããã®ãããããŸãã
æäžåäœåœ¢æ äžã«æå¹æåã10ã1000mgå«æãã
ããã®ãããã ã€ãã«åèäŸããã³å®æœäŸãæããŠæ¬çºæãã
ãã«å ·äœçã«èª¬æããããæ¬çºæã¯ãããã«éå®
ããããã®ã§ã¯ãªãã åèäŸ ïŒ ïœâã¢ããå®æ¯éŠé ž100ïœããšãŒãã«ïŒã«æž
æ¿ãã宀枩ãæ¹æäžãβâãšããã·ã¢ã¯ãªã«é žã¯
ãã©ã€ã44.6ïœã滎äžããããã®æ··åç©ã40âã§
ïŒæéåå¿åŸãæåºç©ãåãããçµæ¶ãïŒåæ°Ž
æŽã也ç¥ããã¡ã¿ããŒã«ããåçµæ¶ããŠç¡è²ç¶¿ç¶
æ¶ã®ïœâã«ã«ããã·ââïŒÎ²âãšããã·ã¢ã¯ãª
ãã€ã«ïŒã¢ããªã³60ïœãåŸããèç¹200.5ã202.0
â åèäŸ ïŒ ïŒâããšãã«ããããªã³é žã¡ãã«50ïœãã¯ãã
ã¢ã»ãã«ã¯ãã©ã€ã51.6ïœããã³ãžã¯ããã¡ã¿ã³
250mlã®æ··åç©ãïŒâã«å·åŽãããïŒã10âã§æ¹
æäžãå¡©åã¢ã«ãããŠã 122ïœãåŸã ã«å ããã
ãã®åŸå®€æž©ã§ïŒæéæ¹æããã宀枩ã§äžå€æŸçœ®
åŸãåå¿æ··åç©ãæ°·âæ¿å¡©é žäžã«æ³šããã¯ããã
ã«ã ã§æœåºãããã¯ãããã«ã å±€ãæ°ŽæŽã也ç¥ã
ãŠãã¯ãããã«ã ãçå»ãããæ®æž£ã«ã€ãœããã
ã«ãšãŒãã«ãå ããŠçµæ¶åããçµæ¶ãåãããš
ã¿ããŒã«ããåçµæ¶ããŠç¡è²éç¶æ¶ã®ïŒâïŒïŒâ
ã¯ããã¢ã»ãã«ããšãã«ïŒããããªã³é žã¡ãã«
53.4ïœãåŸããèç¹90.0ã92.0â åèäŸ ïŒ ïŒâïŒïŒâã¯ããã¢ã»ãã«ããšãã«ïŒããããª
ã³é žã¡ãã«36.26ïœãæ¿ç¡«é ž300mlã«æº¶è§£ããçºç
ç¡é žïŒïœïŒ1.52ïŒ20.9ïœãæ°·æ°Žå·äžæ¹æããªãã
滎äžããã宀枩ã§ïŒæéæ¹æããã®ã¡ãåå¿æ··å
ç©ãæ°·æ°Žäžã«æ³šããã¯ãããã«ã ã§æœåºãããã¯
ãããã«ã å±€ãæ°ŽæŽã也ç¥åŸãã¯ãããã«ã ãç
å»ãããæ®æž£ãã·ãªã«ã²ã«ã«ã©ã ã¯ãããã°ã©ã
ã€ã§ç²Ÿè£œãããšãŒãã«ãå ããŠçµæ¶åãããçµæ¶
ãåããã¡ã¿ããŒã«ããåçµæ¶ããŠæ·¡é»è²ããª
ãºã æ¶ã®ïŒâïŒïŒâã«ã«ããã·âïŒâãããããš
ãã«ïŒããããªã³é žã¡ãã«26.7ïœãåŸããèç¹
120.0ã122.0â åèäŸ ïŒ ã¯ããã¢ã»ãã«ã¯ãã©ã€ã467ïœã®ãžã¯ããã¡
ã¿ã³400ml溶液ã«30â以äžã§æ¹æäžãå¡©åã¢ã«ã
ããŠã 735ïœã1/3ã¥ã€å ããã次ã«å枩床ã»æ¹æ
äžã«ã«ãã¹ããªã«200ïœãå ããããã®æ··å液ã
ïŒæéå ç±éæµããã®ã¡ãåå¿æ··åç©ãæ°·âæ¿å¡©
é žäžã«æ³šããæåºããçµæ¶ãåããããããã¡
ã¿ããŒã«ãç±ã¡ã¿ããŒã«ã§æŽæµããŠïŒâã¯ããã¢
ã»ãã«ã«ã«ãã¹ããªã«153ïœãåŸããæ¯æ¶²ãæ¿çž®
也åºããæ®æž£ãã·ãªã«ã²ã«ã«ã©ã ã¯ãããã°ã©ã
ã€ã§ç²Ÿè£œããã¡ã¿ããŒã«ããåçµæ¶ããŠæ·¡é»è²é
ç¶æ¶ã®ïŒâã¯ããã¢ã»ãã«ã«ã«ãã¹ããªã«35.41
ïœãåŸããèç¹177.5ã179.0â åèäŸ ïŒ ïŒâã¯ããã¢ã»ãã«ã«ã«ãã¹ããªã«30ïœãšããª
ãžã³300mlãæ··åãã80ã90âã§2.5æéå ç±æ¹æ
ãããåå¿æ¶²ãæ°·æ°Žå·ããæåºããçµæ¶ãå
ãããšãŒãã«ã§æŽæµåŸãã¡ã¿ããŒã«ããåçµæ¶ã
ãŠç¡è²éç¶æ¶ã®ïŒâïŒÎ±âããªãžããŠã ã¢ã»ãã«ïŒ
ã«ã«ãã¹ããªã«ã¯ãã©ã€ã40.85ïœãåŸããèç¹
261.5ã264.0âïŒåè§£ïŒ åèäŸ ïŒ ïœâã¢ããå®æ¯éŠé žã¡ãã«29.5ïœã®ãžãšãã«ãš
ãŒãã«300ml溶液ã«ãæ¹æäž17ã27âã§Î²âãšã
ãã·ã¢ã¯ãªã«é žã¯ãã©ã€ã11.53ïœã滎äžããã
滎äžåŸã宀枩ã§ïŒæéæ¹æããæåºæ¶ãåã
ãããšãŒãã«æŽæµåŸãç²çµæ¶ãã¯ãããã«ã ã«æº¶
解ãã0.5Nå¡©é žã飜åçé žæ°ŽçŽ ãããªãŠã ã飜
åé£å¡©æ°Žã§æŽæµããã也ç¥åŸãã¯ãããã«ã ãç
å»ããæ®æž£ãã·ãªã«ã²ã«ã«ã©ã ã¯ãããã°ã©ãã€
ã§ç²Ÿè£œããã€ãã§ã¡ã¿ããŒã«ããåçµæ¶ããŠãç¡
è²ããªãºã ç¶æ¶ã®13.63ïœã®ïœâã¡ããã·ã«ã«ã
ãã«ââïŒÎ²âãšããã·ã¢ã¯ãªãã€ã«ïŒã¢ããª
ã³ãåŸããèç¹108ã110â åèäŸ ïŒ (a) ïŒâïŒÎ±âã¯ããã¢ã»ãã«ïŒã«ã«ãã¹ããªã«
60ïœãããªãžã³0.5Kgã«æžæ¿ãã80ã90âã§ïŒ
æéæ¹æããç¶ããŠæ°·å·äžïŒæéæ¹æãããæ
åºæ¶ãåããã¡ã¿ããŒã«ããåçµæ¶ããŠç¡è²
éç¶æ¶ã®ïŒâïŒÎ±âããªãžããŠã ã¢ã»ãã«ïŒã«
ã«ãã¹ããªã«ã¯ãã©ã€ã1/2æ°Žåç©70ïœãåŸãã
èç¹300âä»¥äž (b) ïŒâïŒÎ±âããªãžããŠã ã¢ã»ãã«ïŒã«ã«ãã¹
ããªã«ã¯ãã©ã€ã69.7ïœããã³æ°Žé žåãããªãŠ
ã 65ïœãæ°Ž0.6ã«æº¶è§£ãã60ã70âã§ïŒæé
æ¹æãããæ°·å·äžãåå¿æ··åç©ã«æ¿å¡©é žãå ã
ãŠãPHâïŒãšãããæåºæ¶ãåããDMFã
ãåçµæ¶ããŠæ·¡è¶è²ç²æ«ç¶æ¶ã®ïŒâã«ã«ããã·
ã«ã«ãã¹ããªã«41.4ïœãåŸããèç¹300âä»¥äž åèäŸ ïŒ åèäŸïŒãšåæ§ã«ããŠé©åœãªåºçºåæãçšããŠ
以äžã®ååç©ãåŸãã ïŒâã«ã«ããã·âïŒïŒïŒâãžãããã«ã«ãã¹ã
ãªã«ãæ·¡é»è²ç²æ«ç¶æ¶ïŒãžã¡ãã«ãã«ã ã¢ããïŒ
èç¹300âä»¥äž ïŒâã«ã«ããã·ã«ã«ãã¹ããªã«ãç¡è²éç¶æ¶
ïŒã¡ã¿ããŒã«âã¯ãããã«ã ïŒãèç¹320â以äžã
NMRïŒDMSOïŒÎŽ6.57ïŒd.JïŒ9.5Hzã1HïŒã7.25
ïŒïœïŒïŒªïŒ8.0Hzã1HïŒã7.94ïŒïœïŒïœïŒïŒªïŒ8.0Hzã
1.5Hzã1HïŒã7.98ïŒïœïŒïŒªïŒ9.5Hzã1HïŒã8.14
ïŒïœïŒïœïŒïŒªïŒ8.0Hzã1.5Hzã1HïŒ åèäŸ ïŒ ïŒâã«ã«ããã·âïŒïŒïŒâãžãããã«ã«ãã¹ã
ãªã«10ïœããã³ïŒ®âããããã·ã³ãã¯é žã€ãã
6.0ïœããžãªããµã³200mlã«æžæ¿ããããã€ãã«æ°·
å·æ¹æäžããžã·ã¯ãããã·ã«ã«ã«ããžã€ãã12.4
ïœã®50mlãžãªããµã³æº¶æ¶²ã滎äžããããã®æ··å液
ã90âã§ïŒæéå ç±æ¹æãããåå¿çµäºåŸã宀枩
ãŸã§æŸå·ããæåºæ¶ãå»ãã液ãæ¿çž®ä¹Ÿåº
ãããã®æ®æž£ããžã¡ãã«ãã«ã ã¢ããâãšã¿ããŒ
ã«ããåçµæ¶ããŠç¡è²ãªã³çç¶æ¶ã®ã³ãã¯é žã€ã
ãïŒïŒïŒâãžãããã«ã«ãã¹ããªã«âïŒâã«ã«ã
ãã·ã¬ãŒã10.8ïœãåŸããèç¹234.5ã236â åèäŸ 10 ïœâã«ã«ããã·ââïŒÎ²âãšããã·ã¢ã¯ãªã
ã€ã«ïŒã¢ããªã³ïŒïœãæ¿ç¡«é ž80mlã«å ãã宀枩ã§
ïŒæéãç¶ããŠ50âã§ïŒæéæ¹æãããåå¿æ¶²ã
æ°·äžã«æ³šãã10Næ°Žé žåãããªãŠã 氎溶液ã§PHïŒ
ãïŒã«èª¿æŽãããæåºæ¶ãåããæ°ŽæŽããŠ
DMFããåçµæ¶ããŠæ·¡é»è²ç²æ«ç¶æ¶ã®ïŒâã«ã«
ããã·ã«ã«ãã¹ãã«4.26ïœãåŸããèç¹320â以
äž NMRïŒDMSOïŒÎŽ6.58ïŒd.JïŒ9.5Hzã1HïŒã7.40
ã7.80ïŒïœïŒ3HïŒã8.69ïŒïœïŒïŒªïŒ9.5Hzã1HïŒ åèäŸ 11 ïŒâïŒïŒâã«ã«ããã·âïŒâãããããšãã«ïŒ
ããããªã³é žã¡ãã«ïŒïœã2.226Næ°Žé žåãããª
ãŠã ã¡ã¿ããŒã«æº¶æ¶²8.87mlãã¡ã¿ããŒã«100mlã
ãã³ïŒïŒ PdâïŒ50ïŒ å«æ°ŽïŒïŒïœãæ··åããåžž
æž©ãåžžå§ã§æ¥è§Šéå ããã觊åªãå»ããæ¯æ¶²ã«
æ¿å¡©é žãå ãPHâïŒã«èª¿æŽããæåºããçµæ¶ã
åããç¡è²éç¶æ¶ã®ã¡ã¿ããŒã«ããåçµæ¶ããŠã
ïŒâã«ã«ããã·âïŒïŒïŒâãžãããã«ã«ãã¹ããª
ã«3.62ïœãåŸããèç¹320âä»¥äž NMRïŒDMSOïŒÎŽ2.33ã2.60ïŒïœã2HïŒã2.77ã
3.05ïŒïœïŒ2HïŒã7.21ïŒïœïŒïŒªïŒ8.5Hzã1HïŒã7.38
ã7.53ïŒïœã2HïŒã10.15ïŒïœã1HïŒ åèäŸ 12 ïœâã¡ããã·ã«ã«ããã«ââïŒÎ²âãšããã·
ã¢ã¯ãã€ã«ïŒã¢ããªã³10ïœãæ¿ç¡«é ž100mläžã«
åŸã ã«å ãã宀枩ã§ïŒæéã45âã§ïŒæéæ¹æã
ããåå¿æ¶²ãæ°·äžã«æ³šããæåºæ¶ãåãæ°ŽæŽã
ããåŸãããç²çµæ¶ãã¡ã¿ããŒã«âã¯ãããã«ã
ã§åçµæ¶ããŠã6.97ïœã®ïŒâã¡ããã·ã«ã«ããã«
ã«ã«ãã¹ããªã«ãåŸããèç¹277.5ã279.0â åèäŸ 13 ïŒâã«ã«ããã·ã«ã«ãã¹ããªã«ïŒïœãæ°Ž30mlã«
æžæ¿ããããã«10Næ°Žé žåãããªãŠã 氎溶液ãå
ããŠçµæ¶ã溶解ããã溶液ã«10ïŒ PtâC500mgã
å ããŠãæ°ŽçŽ å§ïŒãïŒKgïŒcm2ã70âã§æ¥è§Šéå ã
ããåå¿åŸã觊åªãå»ãã液ã«æ¿å¡©é žãå ã
ãŠãPHâïŒãšããæåºæ¶ãåããã¡ã¿ããŒã«ã
ãåçµæ¶ããŠç¡è²éç¶æ¶ã®ïŒâã«ã«ããã·âïŒïŒ
ïŒâãžãããã«ã«ãã¹ããªã«820mgãåŸããèç¹
309ã311â åèäŸ 14 ïŒâã«ã«ããã·ã«ã«ãã¹ããªã«ïŒïœãã¡ã¿ããŒ
ã«100mlã«æžæ¿ããå¡©é žã¬ã¹ãããã«ããŠé£œåã
ãã®ã¡ãïŒæééæµãããåå¿æ¶²ãåéã«ãªããŸ
ã§æ¿çž®ããæåºããçµæ¶ãåãããã·ãªã«ã²ã«
ã«ã©ã ã¯ãããã°ã©ãã€ã§ç²Ÿè£œãã次ãã§ã¡ã¿ã
ãŒã«âã¯ãããã«ã ããåçµæ¶ããŠç¡è²ç²æ«ç¶æ¶
ã®ïŒâã¡ããã·ã«ã«ããã«ã«ã«ãã¹ããªã«230mg
ãåŸããèç¹277.5ã279â åèäŸ 15 ïŒâïŒÎ±âããªãžããŠã ã¢ã»ãã«ïŒã«ã«ãã¹ã
ãªã«ã¯ãã©ã€ãïŒïœãã¡ã¿ããŒã«20mlã«æº¶è§£ãã
ããã«1.01ïœã®DBUãå ããïŒæééæµããã
åå¿æ¶²ãæ¿çž®ä¹Ÿåºããæ®æž£ã«æ°Žãã¯ãããã«ã ã
1Nå¡©é žãå ãããã¯ãããã«ã å±€ãæ°Žã飜åç
é žæ°ŽçŽ ãããªãŠã 氎溶液ã飜åé£å¡©æ°Žã®é ã«æŽæµ
åŸã也ç¥ãããã¯ãããã«ã ãçå»ããåŸããã
æ®æž£ãã·ãªã«ã²ã«ã«ã©ã ã¯ãããã°ã©ãã€ã§ç²Ÿè£œ
ããã€ãã§ã¡ã¿ããŒã«ããåçµæ¶ããŠç¡è²éç¶æ¶
ã®ïŒâã¡ããã·ã«ã«ããã«ã«ã«ãã¹ããªã«130mg
ãåŸããèç¹140ã142â åèäŸ 16 ïŒâãã«ãã«ã«ã«ãã¹ããªã«34ïœãã¡ã¿ããŒã«
800mlã«æžæ¿ãããæ°·å·æ¹æäžãæ°ŽçŽ åããŠçŽ ã
ããªãŠã 7.4ïœãå°éãã€æ·»å ãããæ°·å·äžãïŒ
æéæ¹æãè¡ãªããæåºæ¶ãåããã¡ã¿ããŒã«
ããåçµæ¶ããŠç¡è²ããªãºã ç¶ã®ïŒâããããã·
ã¡ãã«ã«ã«ãã¹ããªã«33.2ïœãåŸããèç¹238ã
239.5â åèäŸ 17 æ°ŽçŽ åãªããŠã ã¢ã«ãããŠã 16ïœã也ç¥ããã©
ããããã©ã³200mlã«æžæ¿ããã宀枩ã§æ¹æããª
ããïŒâã¡ããã·ã«ã«ããã«ã«ã«ãã¹ããªã«16ïœ
ãæ·»å ããã宀枩ã§ïŒæéæ¹æãããé ¢é žãšãã«
ã滎äžããéå°ã®æ°ŽçŽ åãªããŠã ã¢ã«ãããŠã ã
å解ãããããã«æ°Žãå ããã®ã¡ãæžå§æ¿çž®ã
ããæ®æž£ã«åžç¡«é žãå ããæåºæ¶ãåããã¡ã¿
ããŒã«ããåçµæ¶ããŠç¡è²ããªãºã ç¶ã®ïŒâãã
ããã·ã¡ãã«ã«ã«ãã¹ããªã«3.7ïœãåŸããèç¹
238ã239.5â åèäŸ 18ã22a åèäŸ16ããã³17ãšåæ§ã«ããŠé©åœãªåºçºåæ
ãçšããŠæ¬¡è¡šã®ååç©ãåŸãã
ãè¡šã
ãè¡šã
åèäŸ 23
ïŒâããããã·ã¡ãã«ã«ã«ãã¹ããªã«ïŒïœã«47
ïŒ èåæ°ŽçŽ é ž50mlãå ããŠã70ã80âã§ïŒæéæ¹
æãããå·åŸãæåºæ¶ãåããã¡ã¿ããŒã«ãã
åçµæ¶ããŠç¡è²éç¶ã®ïŒâããã ã¡ãã«ã«ã«ãã¹
ããªã«ïŒïœãåŸããèç¹218.5ã219âïŒåè§£ïŒ åèäŸ 24 ïŒâããããã·ã¡ãã«ã«ã«ãã¹ããªã«ïŒïœãã¯
ãããã«ã 100mlã«æžæ¿ããã宀枩ã§æ¹æããªã
ãå¡©åããªãã«ïŒïœã®ã¯ãããã«ã 20ml溶液ã滎
äžããã宀枩ã§ïŒæéæ¹æãããæžå§æ¿çž®ããæ®
枣ãã¡ã¿ããŒã«ããåçµæ¶ããŠç¡è²éç¶ã®ïŒâã¯
ãã«ã¡ãã«ã«ã«ãã¹ããªã«2.9ïœãåŸããèç¹204
ã205â åèäŸ 25 ïŒâã¯ãã«âïŒâã¯ãã«ã¡ãã«ãããªã³2.8ïœ
ãé ¢é ž30mlã«æº¶è§£ããïŒæééæµãè¡ãªããåå¿
液ãæ°Žã«ãããæåºæ¶ãåãããã¡ã¿ããŒã«ã
ãåçµæ¶ããŠç¡è²éç¶ã®ïŒâã¯ãã«ã¡ãã«ã«ã«ã
ã¹ããªã«2.1ïœãåŸããèç¹204ã205â åèäŸ 26ã39 åèäŸ23ã25ãšåæ§ã«ããŠé©åœãªåºçºåæãçš
ããŠæ¬¡è¡šã®ååç©ãåŸãã
ïŒ èåæ°ŽçŽ é ž50mlãå ããŠã70ã80âã§ïŒæéæ¹
æãããå·åŸãæåºæ¶ãåããã¡ã¿ããŒã«ãã
åçµæ¶ããŠç¡è²éç¶ã®ïŒâããã ã¡ãã«ã«ã«ãã¹
ããªã«ïŒïœãåŸããèç¹218.5ã219âïŒåè§£ïŒ åèäŸ 24 ïŒâããããã·ã¡ãã«ã«ã«ãã¹ããªã«ïŒïœãã¯
ãããã«ã 100mlã«æžæ¿ããã宀枩ã§æ¹æããªã
ãå¡©åããªãã«ïŒïœã®ã¯ãããã«ã 20ml溶液ã滎
äžããã宀枩ã§ïŒæéæ¹æãããæžå§æ¿çž®ããæ®
枣ãã¡ã¿ããŒã«ããåçµæ¶ããŠç¡è²éç¶ã®ïŒâã¯
ãã«ã¡ãã«ã«ã«ãã¹ããªã«2.9ïœãåŸããèç¹204
ã205â åèäŸ 25 ïŒâã¯ãã«âïŒâã¯ãã«ã¡ãã«ãããªã³2.8ïœ
ãé ¢é ž30mlã«æº¶è§£ããïŒæééæµãè¡ãªããåå¿
液ãæ°Žã«ãããæåºæ¶ãåãããã¡ã¿ããŒã«ã
ãåçµæ¶ããŠç¡è²éç¶ã®ïŒâã¯ãã«ã¡ãã«ã«ã«ã
ã¹ããªã«2.1ïœãåŸããèç¹204ã205â åèäŸ 26ã39 åèäŸ23ã25ãšåæ§ã«ããŠé©åœãªåºçºåæãçš
ããŠæ¬¡è¡šã®ååç©ãåŸãã
ãè¡šã
ãè¡šã
åèäŸ 40
ãããªãŠã 1.5ïœãšä¹Ÿç¥ãšã¿ããŒã«150mlãšãã
ãããªãŠã ãšãã©ãŒããã€ãããããã«ã¢ã»ãã¢
ããããã³é žãžãšãã«12ïœãå ããŠå®€æž©ã§ïŒæé
æ¹æãããïŒâããã ã¡ãã«ã«ã«ãã¹ããªã«12ïœ
ãå ããŠãïŒæééæµãè¡ãªãããšã¿ããŒã«ãç
å»ããæ®æž£ã«æ°Žãå ããæåºæ¶ãåããããšã¿
ããŒã«ããåçµæ¶ããŠç¡è²ããªãºã ç¶ã®ãšãã«ïŒ
âã¢ã»ãã¢ããâïŒâã«ã«ããšããã·âïŒâïŒïŒ
âãããã³âïŒâã€ã«ïŒããããªããŒã13ïœãåŸ
ããèç¹224ã226âïŒåè§£ïŒ åèäŸ 41ã58 åèäŸ40ãšåæ§ã«ããŠé©åœãªåºçºåæãçšããŠ
次衚ã®ååç©ãåŸãã
ãããªãŠã ãšãã©ãŒããã€ãããããã«ã¢ã»ãã¢
ããããã³é žãžãšãã«12ïœãå ããŠå®€æž©ã§ïŒæé
æ¹æãããïŒâããã ã¡ãã«ã«ã«ãã¹ããªã«12ïœ
ãå ããŠãïŒæééæµãè¡ãªãããšã¿ããŒã«ãç
å»ããæ®æž£ã«æ°Žãå ããæåºæ¶ãåããããšã¿
ããŒã«ããåçµæ¶ããŠç¡è²ããªãºã ç¶ã®ãšãã«ïŒ
âã¢ã»ãã¢ããâïŒâã«ã«ããšããã·âïŒâïŒïŒ
âãããã³âïŒâã€ã«ïŒããããªããŒã13ïœãåŸ
ããèç¹224ã226âïŒåè§£ïŒ åèäŸ 41ã58 åèäŸ40ãšåæ§ã«ããŠé©åœãªåºçºåæãçšããŠ
次衚ã®ååç©ãåŸãã
ãè¡šã
ãè¡šã
åèäŸ 59
ãšãã«ïŒâã¢ã»ãã¢ããâïŒâã«ã«ããšããã·
âïŒâïŒïŒâãããã³âïŒâã€ã«ïŒããããªããŒ
ã5.6ïœãããã©ããããã©ã³150mlã«æº¶è§£ããã
ããã«å®€æž©ã§æ¹æããªãã50ïŒ æ²¹æ§æ°ŽçŽ ãããªãŠ
ã 0.8ïœãå ããããšãŠåã¡ãã«4.5ïœã滎äžãã
宀枩ã§ïŒæéæ¹æãããæžå§æ¿çž®ããæ®æž£ãæ°Žã«
ãããŠæåºæ¶ãåããããšã¿ããŒã«æ°Žããåçµ
æ¶ããŠç¡è²é±çç¶ã®ãšãã«ïŒâã¢ã»ãã¢ããâïŒ
âã«ã«ããšããã·âïŒâïŒïŒâã¡ãã«âïŒâãã
ãã³âïŒâã€ã«ïŒããããªããŒã3.5ïœãåŸãã
èç¹190.5ã192â äžèšåèäŸ59ãšåæ§ã«ããŠåèšåèäŸ45ïŒ48ïŒ
51ïŒ52ããã³57ã®ååç©ãåŸãã åèäŸ 60 æ°ŽçŽ åãªããŠã ã¢ã«ãããŠã 1.9ïœã也ç¥ãã
ã©ããããã©ã³100mlã«æžæ¿ãããããã«å®€æž©ã§
æ¹æããªããïŒâã«ã«ããã·ã«ã«ãã¹ããªã«1.9
ïœãæ·»å ããã宀枩ã§ïŒæ©æ¹æãè¡ãªããéå°ã®
æ°ŽçŽ åãªããŠã ã¢ã«ãããŠã ããé ¢é žãšãã«ã滎
äžããŠå解ãããåžç¡«é žãå ããŠé žæ§ãšãããã
ããããããã©ã³ãæžå§çå»åŸãæåºããŠããçµ
æ¶ãåãããã¡ã¿ããŒã«ããåçµæ¶ããŠç¡è²ã
ãªãºã ç¶ã®ïŒâããããã·ã¡ãã«ã«ã«ãã¹ããªã«
0.5ïœãåŸããèç¹238ã239.5âã äžèšåèäŸ60ãšåæ§ã«ããŠé©åœãªåºçºåæãçš
ããŠãåèšåèäŸ18ã22ã®ååç©ãåŸãã åèäŸ 61 ã¢ã»ãé ¢é žã¢ããªã30ïœãã¯ãããã«ã 30mlã«
溶解ãããããã«å®€æž©ã§æ¹æããªããèçŽ 27ïœã®
ã¯ãããã«ã 30ml溶液ã滎äžããã滎äžåŸã30å
éæµãè¡ãªããæžå§æ¿çž®ããæ®æž£ãæ¿ç¡«é ž70mläž
ã«æ¹æããªããæ·»å ãããå æž©ã70ã75âã«ä¿ã¡
ãªããå ãã95âã§30åæ¹æãããåå¿æ¶²ãæ°·æ°Ž
ã«ãããŠæåºæ¶ãåãããã¡ã¿ããŒã«âã¯ãã
ãã«ã ããåçµæ¶ããŠç¡è²éç¶ã®ïŒâããã ã¡ã
ã«ã«ã«ãã¹ããªã«20ïœãåŸããèç¹265ã266â äžèšåèäŸ61ãšåæ§ã«ããŠãé©åœãªåºçºåæã
çšããŠåèšåèäŸ23ïŒ24ïŒ26ã28ããã³30ã37ã®
ååç©ãåŸãã åèäŸ 62 ïŒâã¯ãã«ã¡ãã«âïŒâã¡ããã·ã«ã«ãã¹ããª
ã«2.2ïœãç¡æ°Žé ¢é ž20mlã«æº¶è§£ãããããã«é ¢é ž
ã«ãªãŠã 12ïœãå ããŠã60ã70âã§ïŒæéæ¹æã
è¡ãªããåå¿æ¶²ãæ°·æ°Žã«ãããŠãæåºæ¶ãåã
ããã¢ã»ãã³ããåçµæ¶ããŠãç¡è²ããªãºã ç¶ã®
ïŒâã¢ã»ããã·ã¡ãã«âïŒâã¡ããã·ã«ã«ãã¹ã
ãªã«ïŒïœãåŸããèç¹166ã168â åèäŸ 63 ïŒâã¢ã»ããã·ã¡ãã«ã«ã«ãã¹ããªã«ïŒïœãæ°Ž
é žåãããªãŠã 0.6ïœãå«ãã¡ã¿ããŒã«30mlã«æº¶
解ããïŒæééæµãè¡ãªããã¡ã¿ããŒã«ãçå»
åŸãæ®æž£ã«æ°Žãå ããæåºæ¶ãåãããã¢ã»ã
ã³ããåçµæ¶ããŠæ·¡é»è²éç¶ã®ïŒâããããã·ã¡
ãã«âïŒâã¡ããã·ã«ã«ãã¹ããªã«1.3ïœãåŸãã
èç¹196ã197â äžèšåèäŸ63ãšåæ§ã«ããŠé©åœãªåºçºåæãçš
ããŠãåèäŸ16ããã³19ã22ã®ååç©ãåŸãã åèäŸ 64 (a) åã€å£ãã©ã¹ã³ã«æ°Ž175mlãšç¡«é žç¬¬äžéïŒæ°Ž
åç©10.5ïœãæ¿å¡©é ž0.5mlããã³ïœâãããã
ã³ãºã¢ã«ãããïŒïœãã¯ããã氎溶äžã§90âã«
å ç±ãããæ¹æããªããæ¿ã¢ã³ã¢ãã¢æ°Ž25mlã
äžåºŠã«å ãããããã«ïŒåæ¯ã«ã¢ã³ã¢ãã¢æ°Ž30
mlãïŒåºŠã«åããŠå ãããæ·»å çµäºåŸãçŽã¡ã«
æ°Žèžæ°èžçãè¡ãªããç液250mlãäºåºŠéããã
æåã®ç液ãå·åŽããæåºæ¶ãåãããæ¯æ¶²
ãšäºçªç®ã®ç液ãããããŠãé£å¡©ã§é£œåãããš
ãŒãã«æœåºãè¡ãªãããšãŒãã«æº¶æ¶²ã¯ç¡«é žãã
ãªãŠã ã§ä¹Ÿç¥ãããšãŒãã«ãçå»ãããæ®æž£ãš
ããã®çµæ¶ãšãããããŠä¹Ÿç¥ããé»è²é±çç¶ã®
ïœâã¢ãããã³ãºã¢ã«ããã2.9ïœãåŸããè
ç¹38ã39â (b) ããã³é žïŒïœãããªãžã³15mlã«æº¶è§£ãããã
ãã«ïœâã¢ãããã³ãºã¢ã«ããã1.2ïœãšãã
ãªãžã³ïŒmlãšãå ãã90âã§ïŒæéæ¹æããã
åå¿æ¶²ãå¡©é žæ°Žæº¶æ¶²ã«ãããŠæåºæ¶ãåã
ããã¡ã¿ããŒã«âã¯ãããã«ã ããåçµæ¶ããŠ
ç¡è²éç¶ã®ïŒâã«ã«ããã·ã«ã«ãã¹ããªã«1.2
ïœãåŸããèç¹300âä»¥äž åèäŸ 65 ã€ãµãã³60ïœã«ç¡æ°Žé ¢é ž140mlãå ããŠïŒæé
éæµãè¡ãªããå·åŸãæåºæ¶ãåãããšãŒãã«
ã§æŽæµããâã¢ã»ãã«ã€ãµãã³58ïœãåŸãã æ°Žé žåãããªãŠã 30ïœãæ°Ž1.5ã«æº¶è§£ããã
ããã«äžèšïŒ®âã¢ã»ãã«ã€ãµãã³58ïœãå ããŠïŒ
æééæµãè¡ãªãããããå·åŽãã掻æ§çãå
ãã30åéæµãããç±æ掻æ§çãå»ãããæ¯æ¶²
ãå·åŽããïŒèŠå®å¡©é žã§PHïŒãïŒãšãããæåºã
ãŠããçµæ¶ãåããæ°Žã§æŽæµåŸã也ç¥ããŠãïŒ
âã«ã«ããã·ã«ã«ãã¹ããªã«45ïœãåŸããèç¹
300âä»¥äž åèäŸ 66 (a) ïŒïŒ®âãžã¡ãã«ãã«ã ã¢ãã96mlã«æ°·å·æ¹
æäžããªãã·å¡©åãªã³322mlã滎äžãããåæž©
床ã§ã¢ã»ãã¢ããªã67.5ïœãå ãã75âã§18.5
æéæ¹æãè¡ãªããåå¿æ¶²ãæ°·ã«ãããŠæåºæ¶
ãåãã也ç¥ãããé ¢é žãšãã«ããåçµæ¶ã
ãŠé»è²éç¶ã®ïŒâã¯ãã«âïŒâãã«ãã«ã«ã«ã
ã¹ããªã«55.2ïœãåŸããèç¹149ã151â (b) ïŒâã¯ãã«âïŒâãã«ãã«ãããªã³37ïœã«ïŒ
èŠå®å¡©é ž600mlãå ããŠïŒæééæµãããå·åŸã
æåºæ¶ãåãããšã¿ããŒã«âã¯ãããã«ã ã
ãåçµæ¶ããŠæ·¡é»è²éç¶æ¶ã®ïŒâãã«ãã«ã«ã«
ãã¹ããªã«34ïœãåŸããèç¹308ã309â (c) ïŒâãã«ãã«ã«ã«ãã¹ããªã«2.7ïœãããã©
ããããã©ã³150mlã«æº¶ãããããã«å®€æž©ã§æ¹
æããªãã50ïŒ æ²¹æ§æ°ŽçŽ åãããªãŠã 0.8ïœã
å ããããšãŠåã¡ãã«4.5ïœã滎äžãã宀枩ã§
ïŒæéæ¹æãããæžå§æ¿çž®ããæ®æž£ãæ°Žã«ãã
ãŠæåºæ¶ãåãããããããšã¿ããŒã«ããå
çµæ¶ããŠé»è€è²éç¶æ¶ã®ïŒâã¡ãã«âïŒâãã«
ãã«ã«ã«ãã¹ããªã«1.7ïœãåŸããèç¹211ã
214â åèäŸ 67 ïŒïŒ®âãžã¡ãã«ãã«ã ã¢ãã11.6mlã«ïŒâã§
æ¹æããªãããªãã·å¡©åãªã³64.4mlã滎äžããã
å枩床ã§ïŒ®âããšãã«âïŒâã¯ãã«ããããªã³ã¢
ãã18.4ïœãå ããã75ã80âã§10æéæ¹æã
ããåå¿æ¶²ããããŠãæåºæ¶ãåããããšã¿ã
ãŒã«ããåçµæ¶ããŠç¡è²ããªãºã ç¶ã®ïŒâã¯ãã«
âïŒâã¯ãã«ã¡ãã«ãããªã³6.7ïœãåŸããèç¹
116ã118â åèäŸ 68 ïŒâãã«ãã«ã«ã«ãã¹ããªã«17ïœãâã¢ã»ã
ã«ã°ãªã·ã³18ïœãç¡æ°Žé ¢é žãããªãŠã ïŒïœããã³
ç¡æ°Žé ¢é ž100mlãšã110âã§å æž©ããŠåäžæº¶æ¶²ãš
ããããã«1.5æééæµãããå·åŽåŸãå·æ°Žã«å
ããæåºæ¶ãåãããå·æ°Žã§æŽæµãããšã¿ããŒ
ã«âã¯ãããã«ã ããåçµæ¶ããŠïŒâïŒïŒïŒïŒâ
ãžãããâïŒâãªããœâãããªãªãã³ïŒâïŒâã¡
ãã«âïŒâãªããµãŸãã³ã»1/2H2O10ïœãåŸãã
èç¹275ã277âïŒåè§£ïŒ åèäŸ 69ã70 åèäŸ65ãšåæ§ã«ããŠé©åœãªåºçºç©è³ªãçšããŠ
次衚ã®ååç©ãåŸãã
âïŒâïŒïŒâãããã³âïŒâã€ã«ïŒããããªããŒ
ã5.6ïœãããã©ããããã©ã³150mlã«æº¶è§£ããã
ããã«å®€æž©ã§æ¹æããªãã50ïŒ æ²¹æ§æ°ŽçŽ ãããªãŠ
ã 0.8ïœãå ããããšãŠåã¡ãã«4.5ïœã滎äžãã
宀枩ã§ïŒæéæ¹æãããæžå§æ¿çž®ããæ®æž£ãæ°Žã«
ãããŠæåºæ¶ãåããããšã¿ããŒã«æ°Žããåçµ
æ¶ããŠç¡è²é±çç¶ã®ãšãã«ïŒâã¢ã»ãã¢ããâïŒ
âã«ã«ããšããã·âïŒâïŒïŒâã¡ãã«âïŒâãã
ãã³âïŒâã€ã«ïŒããããªããŒã3.5ïœãåŸãã
èç¹190.5ã192â äžèšåèäŸ59ãšåæ§ã«ããŠåèšåèäŸ45ïŒ48ïŒ
51ïŒ52ããã³57ã®ååç©ãåŸãã åèäŸ 60 æ°ŽçŽ åãªããŠã ã¢ã«ãããŠã 1.9ïœã也ç¥ãã
ã©ããããã©ã³100mlã«æžæ¿ãããããã«å®€æž©ã§
æ¹æããªããïŒâã«ã«ããã·ã«ã«ãã¹ããªã«1.9
ïœãæ·»å ããã宀枩ã§ïŒæ©æ¹æãè¡ãªããéå°ã®
æ°ŽçŽ åãªããŠã ã¢ã«ãããŠã ããé ¢é žãšãã«ã滎
äžããŠå解ãããåžç¡«é žãå ããŠé žæ§ãšãããã
ããããããã©ã³ãæžå§çå»åŸãæåºããŠããçµ
æ¶ãåãããã¡ã¿ããŒã«ããåçµæ¶ããŠç¡è²ã
ãªãºã ç¶ã®ïŒâããããã·ã¡ãã«ã«ã«ãã¹ããªã«
0.5ïœãåŸããèç¹238ã239.5âã äžèšåèäŸ60ãšåæ§ã«ããŠé©åœãªåºçºåæãçš
ããŠãåèšåèäŸ18ã22ã®ååç©ãåŸãã åèäŸ 61 ã¢ã»ãé ¢é žã¢ããªã30ïœãã¯ãããã«ã 30mlã«
溶解ãããããã«å®€æž©ã§æ¹æããªããèçŽ 27ïœã®
ã¯ãããã«ã 30ml溶液ã滎äžããã滎äžåŸã30å
éæµãè¡ãªããæžå§æ¿çž®ããæ®æž£ãæ¿ç¡«é ž70mläž
ã«æ¹æããªããæ·»å ãããå æž©ã70ã75âã«ä¿ã¡
ãªããå ãã95âã§30åæ¹æãããåå¿æ¶²ãæ°·æ°Ž
ã«ãããŠæåºæ¶ãåãããã¡ã¿ããŒã«âã¯ãã
ãã«ã ããåçµæ¶ããŠç¡è²éç¶ã®ïŒâããã ã¡ã
ã«ã«ã«ãã¹ããªã«20ïœãåŸããèç¹265ã266â äžèšåèäŸ61ãšåæ§ã«ããŠãé©åœãªåºçºåæã
çšããŠåèšåèäŸ23ïŒ24ïŒ26ã28ããã³30ã37ã®
ååç©ãåŸãã åèäŸ 62 ïŒâã¯ãã«ã¡ãã«âïŒâã¡ããã·ã«ã«ãã¹ããª
ã«2.2ïœãç¡æ°Žé ¢é ž20mlã«æº¶è§£ãããããã«é ¢é ž
ã«ãªãŠã 12ïœãå ããŠã60ã70âã§ïŒæéæ¹æã
è¡ãªããåå¿æ¶²ãæ°·æ°Žã«ãããŠãæåºæ¶ãåã
ããã¢ã»ãã³ããåçµæ¶ããŠãç¡è²ããªãºã ç¶ã®
ïŒâã¢ã»ããã·ã¡ãã«âïŒâã¡ããã·ã«ã«ãã¹ã
ãªã«ïŒïœãåŸããèç¹166ã168â åèäŸ 63 ïŒâã¢ã»ããã·ã¡ãã«ã«ã«ãã¹ããªã«ïŒïœãæ°Ž
é žåãããªãŠã 0.6ïœãå«ãã¡ã¿ããŒã«30mlã«æº¶
解ããïŒæééæµãè¡ãªããã¡ã¿ããŒã«ãçå»
åŸãæ®æž£ã«æ°Žãå ããæåºæ¶ãåãããã¢ã»ã
ã³ããåçµæ¶ããŠæ·¡é»è²éç¶ã®ïŒâããããã·ã¡
ãã«âïŒâã¡ããã·ã«ã«ãã¹ããªã«1.3ïœãåŸãã
èç¹196ã197â äžèšåèäŸ63ãšåæ§ã«ããŠé©åœãªåºçºåæãçš
ããŠãåèäŸ16ããã³19ã22ã®ååç©ãåŸãã åèäŸ 64 (a) åã€å£ãã©ã¹ã³ã«æ°Ž175mlãšç¡«é žç¬¬äžéïŒæ°Ž
åç©10.5ïœãæ¿å¡©é ž0.5mlããã³ïœâãããã
ã³ãºã¢ã«ãããïŒïœãã¯ããã氎溶äžã§90âã«
å ç±ãããæ¹æããªããæ¿ã¢ã³ã¢ãã¢æ°Ž25mlã
äžåºŠã«å ãããããã«ïŒåæ¯ã«ã¢ã³ã¢ãã¢æ°Ž30
mlãïŒåºŠã«åããŠå ãããæ·»å çµäºåŸãçŽã¡ã«
æ°Žèžæ°èžçãè¡ãªããç液250mlãäºåºŠéããã
æåã®ç液ãå·åŽããæåºæ¶ãåãããæ¯æ¶²
ãšäºçªç®ã®ç液ãããããŠãé£å¡©ã§é£œåãããš
ãŒãã«æœåºãè¡ãªãããšãŒãã«æº¶æ¶²ã¯ç¡«é žãã
ãªãŠã ã§ä¹Ÿç¥ãããšãŒãã«ãçå»ãããæ®æž£ãš
ããã®çµæ¶ãšãããããŠä¹Ÿç¥ããé»è²é±çç¶ã®
ïœâã¢ãããã³ãºã¢ã«ããã2.9ïœãåŸããè
ç¹38ã39â (b) ããã³é žïŒïœãããªãžã³15mlã«æº¶è§£ãããã
ãã«ïœâã¢ãããã³ãºã¢ã«ããã1.2ïœãšãã
ãªãžã³ïŒmlãšãå ãã90âã§ïŒæéæ¹æããã
åå¿æ¶²ãå¡©é žæ°Žæº¶æ¶²ã«ãããŠæåºæ¶ãåã
ããã¡ã¿ããŒã«âã¯ãããã«ã ããåçµæ¶ããŠ
ç¡è²éç¶ã®ïŒâã«ã«ããã·ã«ã«ãã¹ããªã«1.2
ïœãåŸããèç¹300âä»¥äž åèäŸ 65 ã€ãµãã³60ïœã«ç¡æ°Žé ¢é ž140mlãå ããŠïŒæé
éæµãè¡ãªããå·åŸãæåºæ¶ãåãããšãŒãã«
ã§æŽæµããâã¢ã»ãã«ã€ãµãã³58ïœãåŸãã æ°Žé žåãããªãŠã 30ïœãæ°Ž1.5ã«æº¶è§£ããã
ããã«äžèšïŒ®âã¢ã»ãã«ã€ãµãã³58ïœãå ããŠïŒ
æééæµãè¡ãªãããããå·åŽãã掻æ§çãå
ãã30åéæµãããç±æ掻æ§çãå»ãããæ¯æ¶²
ãå·åŽããïŒèŠå®å¡©é žã§PHïŒãïŒãšãããæåºã
ãŠããçµæ¶ãåããæ°Žã§æŽæµåŸã也ç¥ããŠãïŒ
âã«ã«ããã·ã«ã«ãã¹ããªã«45ïœãåŸããèç¹
300âä»¥äž åèäŸ 66 (a) ïŒïŒ®âãžã¡ãã«ãã«ã ã¢ãã96mlã«æ°·å·æ¹
æäžããªãã·å¡©åãªã³322mlã滎äžãããåæž©
床ã§ã¢ã»ãã¢ããªã67.5ïœãå ãã75âã§18.5
æéæ¹æãè¡ãªããåå¿æ¶²ãæ°·ã«ãããŠæåºæ¶
ãåãã也ç¥ãããé ¢é žãšãã«ããåçµæ¶ã
ãŠé»è²éç¶ã®ïŒâã¯ãã«âïŒâãã«ãã«ã«ã«ã
ã¹ããªã«55.2ïœãåŸããèç¹149ã151â (b) ïŒâã¯ãã«âïŒâãã«ãã«ãããªã³37ïœã«ïŒ
èŠå®å¡©é ž600mlãå ããŠïŒæééæµãããå·åŸã
æåºæ¶ãåãããšã¿ããŒã«âã¯ãããã«ã ã
ãåçµæ¶ããŠæ·¡é»è²éç¶æ¶ã®ïŒâãã«ãã«ã«ã«
ãã¹ããªã«34ïœãåŸããèç¹308ã309â (c) ïŒâãã«ãã«ã«ã«ãã¹ããªã«2.7ïœãããã©
ããããã©ã³150mlã«æº¶ãããããã«å®€æž©ã§æ¹
æããªãã50ïŒ æ²¹æ§æ°ŽçŽ åãããªãŠã 0.8ïœã
å ããããšãŠåã¡ãã«4.5ïœã滎äžãã宀枩ã§
ïŒæéæ¹æãããæžå§æ¿çž®ããæ®æž£ãæ°Žã«ãã
ãŠæåºæ¶ãåãããããããšã¿ããŒã«ããå
çµæ¶ããŠé»è€è²éç¶æ¶ã®ïŒâã¡ãã«âïŒâãã«
ãã«ã«ã«ãã¹ããªã«1.7ïœãåŸããèç¹211ã
214â åèäŸ 67 ïŒïŒ®âãžã¡ãã«ãã«ã ã¢ãã11.6mlã«ïŒâã§
æ¹æããªãããªãã·å¡©åãªã³64.4mlã滎äžããã
å枩床ã§ïŒ®âããšãã«âïŒâã¯ãã«ããããªã³ã¢
ãã18.4ïœãå ããã75ã80âã§10æéæ¹æã
ããåå¿æ¶²ããããŠãæåºæ¶ãåããããšã¿ã
ãŒã«ããåçµæ¶ããŠç¡è²ããªãºã ç¶ã®ïŒâã¯ãã«
âïŒâã¯ãã«ã¡ãã«ãããªã³6.7ïœãåŸããèç¹
116ã118â åèäŸ 68 ïŒâãã«ãã«ã«ã«ãã¹ããªã«17ïœãâã¢ã»ã
ã«ã°ãªã·ã³18ïœãç¡æ°Žé ¢é žãããªãŠã ïŒïœããã³
ç¡æ°Žé ¢é ž100mlãšã110âã§å æž©ããŠåäžæº¶æ¶²ãš
ããããã«1.5æééæµãããå·åŽåŸãå·æ°Žã«å
ããæåºæ¶ãåãããå·æ°Žã§æŽæµãããšã¿ããŒ
ã«âã¯ãããã«ã ããåçµæ¶ããŠïŒâïŒïŒïŒïŒâ
ãžãããâïŒâãªããœâãããªãªãã³ïŒâïŒâã¡
ãã«âïŒâãªããµãŸãã³ã»1/2H2O10ïœãåŸãã
èç¹275ã277âïŒåè§£ïŒ åèäŸ 69ã70 åèäŸ65ãšåæ§ã«ããŠé©åœãªåºçºç©è³ªãçšããŠ
次衚ã®ååç©ãåŸãã
ãè¡šã
å®æœäŸ ïŒ
ãšãã«ïŒâã¢ã»ãã¢ããâïŒâã«ã«ããã·âïŒ
âïŒïŒâãããã³âïŒâã€ã«ïŒããããªããŒãïŒ
ïœã«20ïŒ å¡©é ž150mlãå ããŠïŒæééæµãè¡ãªãã
æžå§æ¿çž®ããæ®æž£ããšã¿ããŒã«âæ°Žããåçµæ¶ã
ãŠç¡è²ããªãºã ç¶ã®ïŒâã¢ããâïŒâïŒïŒâãã
ãã³âïŒâã€ã«ïŒããããªã³é žå¡©é žå¡©äžæ°Žåç©
3.2ïœãåŸããèç¹220ã225âïŒåè§£ïŒ å®æœäŸ ïŒ ïŒâã¢ããâïŒâïŒïŒâãããã³âïŒâã€ã«ïŒ
ããããªã³é žå¡©é žå¡©1.6ïœãšçé žã«ãªãŠã 2.4ïœãš
ãã¢ã»ãã³60mlãšæ°Ž30mlãšã«æº¶è§£ãããããã«æ°·
å·æ¹æããªããå¡©åïœâã¯ãã«ãã³ãŸã€ã«1.2ïœ
ã®ã¢ã»ãã³10ml溶液ã滎äžãããæ°·å·äžïŒæéæ¹
æãããã¢ã»ãã³ãçå»åŸãæ®æž£ã«æ°Žãå ããŠäž
溶ç©ãå»ããã液ãå¡©é žã§é žæ§ãšããæåºçµ
æ¶ãåããããšã¿ããŒã«âæ°Žããåçµæ¶ããŠã
çœè²ç²æ«ç¶ã®ïŒâïŒïŒâã¯ãã«ãã³ãŸã€ã«ã¢ããïŒ
âïŒâïŒïŒâãããã³âïŒâã€ã«ïŒããããªã³é ž
1.5ïœãåŸããèç¹270ã271.5âïŒåè§£ïŒ å®æœäŸ ïŒ ïŒâã¢ããâïŒâïŒïŒâã¡ããã·âïŒâããã
ã³âïŒâã€ã«ïŒããããªã³é žå¡©é žå¡©1.5ïœãæ°Žé ž
åãããªãŠã 0.8ïœã®æ°Ž25ml溶液ã«æº¶è§£ãããæ°·
å·äžå¡©åïœâã¯ãã«ãã³ãŸã€ã«ïŒïœã滎äžããæ¹
æãããèå±€ã¯ãããã°ã©ãã€ã«ããåæãæ¶å€±
ãããŸã§ïŒ®âæ°Žé žåãããªãŠã 氎溶液ããã³é žã¯
ããªããé©æå ãããåå¿çµäºåŸãå¡©é žé žæ§ãš
ããæåºæ¶ãåããããšãŒãã«ã§æŽæµããã®
ã¡ãã¡ã¿ããŒã«âæ°Žããåçµæ¶ããŠãé»è²ç²æ«ç¶
ã®ïŒâïŒïŒâã¯ãã«ãã³ãŸã€ã«ã¢ããïŒâïŒâïŒïŒ
âã¡ããã·âïŒâãããã³âïŒâã€ã«ïŒããããª
ã³é ž0.7ïœãåŸããèç¹234.5ã236âïŒåè§£ïŒ å®æœäŸ ïŒ ïŒâã¢ããâïŒâïŒïŒâããããã·âïŒâãã
ãã³âïŒâã€ã«ïŒããããªã³é žå¡©é žå¡©ïŒïœãïŒâ
ã¡ãã«âïŒâãããªãã³50mlã«æžæ¿ããïŒâïŒïŒ
âã¯ãã«ãã³ãŸã€ã«ïŒãã³ãºãªããµãŸãªã³âïŒâ
ããªã³2.2ïœãå ããŠå®€æž©ã§ïŒæ¥éæ¹æãããå
å¿æ¶²ãæ°·æ°Žã«ãããŠãæåºæ¶ãåãããçµæ¶ã
âæ°Žé žåãããªãŠã 氎溶液ã«æº¶è§£åŸã10ïŒ å¡©é ž
ã§é žæ§ãšããæåºæ¶ãåãããçµæ¶ã也ç¥åŸã
ã¯ãããã«ã ã§æŽæµãããã¡ã¿ããŒã«âæ°Žããå
çµæ¶ããŠæ·¡é»è²ç²æ«ç¶ã®ïŒâïŒïŒâã¯ãã«ãã³ãŸ
ã€ã«ã¢ããïŒâïŒâïŒïŒâããããã·âïŒâããã
ã³âïŒâã€ã«ïŒããããªã³é ž1.5ïœãåŸããèç¹
223ã227âïŒåè§£ïŒ å®æœäŸ ïŒ ïŒâã¢ããâïŒâïŒïŒâãããã³âïŒâã€ã«ïŒ
ããããªã³é ž1.2ïœãDCC1.3ïœããã³ïœâã¯ãã«
å®æ¯éŠé ž1.0ïœããžãªããµã³10mlã«æžæ¿ããã60
ã70âã§ïŒæéæ¹æãããåå¿çµäºåŸã溶åªãç
å»ãããšãŒãã«ãå ããŠæåºæ¶ãå»ããã液
ãæ¿çž®åŸãæ®æž£ã«ã¯ãããã«ã ãå ããŠæº¶è§£ãã
æ°Žããã³é£œåé£å¡©æ°Žã§æŽæµãããç¡«é žãããªãŠã
ã§ä¹Ÿç¥åŸã溶åªãçå»ããããšã¿ããŒã«âæ°Žãã
åçµæ¶ããŠãçœè²ç²æ«ç¶ã®ïŒâïŒïŒâã¯ãã«ãã³
ãŸã€ã«ã¢ããïŒâïŒâïŒïŒâãããã³âïŒâã€ã«ïŒ
ããããªã³é ž350mgãåŸãã èç¹270ã271.5âïŒåè§£ïŒ å®æœäŸ ïŒ ïŒâã¢ããâïŒâïŒïŒâãããã³âïŒâã€ã«ïŒ
ããããªã³é ž1.2ïœããã³ããªãšãã«ã¢ãã³0.8ml
ãããã©ããããã©ã³10mlã«æžæ¿ããã宀枩æ¹æ
äžã«ãžãšãã«ã¯ãããã¹ããšãŒã1.0ïœã®ããã©
ããããã©ã³10ml溶液ã滎äžãã宀枩ã§ïŒæéæ¹
æããããã®ãã®ã«ïœâã¯ãã«å®æ¯éŠé ž1.0ïœã®
ããã©ããããã©ã³10ml溶液ã滎äžãã宀枩ã§ã
ãã«10æéæ¹æãããåå¿çµäºåŸãæåºæ¶ãå»
ãã液ãæ¿çž®ããŠãæ®æž£ã«é£œåéãœãŠã泚ãã
ã¯ãããã«ã æœåºãããææ©å±€ãæ°Žããã³é£œåé£
å¡©æ°Žã§æŽæµããç¡«é žãããªãŠã ã§ä¹Ÿç¥åŸã溶åªã
çå»ããããšã¿ããŒã«âæ°Žããåçµæ¶ããŠãçœè²
ç²æ«ç¶ã®ïŒâïŒïŒâã¯ãã«ãã³ãŸã€ã«ã¢ããïŒâïŒ
âïŒïŒâãããã³âïŒâã€ã«ïŒããããªã³é ž0.9ïœ
ãåŸããèç¹270ã271.5âïŒåè§£ïŒ å®æœäŸ ïŒ ïœâã¯ãã«å®æ¯éŠé ž4.84ïœããã³ããªãšãã«ã¢
ãã³ïŒmlã®ãžã¡ãã«ãã«ã ã¢ãã50ml溶液ã«ãã€
ãœããã«ã¯ãããã«ã¡ãŒã3.87ïœã®ãžã¡ãã«ãã«
ã ã¢ããïŒml溶液ã滎äžããã宀枩ã§30åéæ¹æ
åŸãïŒâã¢ããâïŒâïŒïŒâãããã³âïŒâã€ã«ïŒ
ããããªã³é ž6.03ïœã®ãžã¡ãã«ãã«ã ã¢ããïŒml
溶液ã滎äžãã宀枩ã§30åãç¶ããŠ50ã60âã§ïŒ
æéæ¹æãããåå¿æ··åç©ãå€éã®é£œåé£å¡©æ°Žã«
泚ã蟌ã¿ãã¯ãããã«ã æœåºããæ°ŽæŽåŸä¹Ÿç¥ã
ãã溶åªãçå»ããŠåŸãããç²çµæ¶ããšã¿ããŒã«
âæ°Žããåçµæ¶ããŠãçœè²ç²æ«ç¶ã®ïŒâïŒïŒâã¯
ãã«ãã³ãŸã€ã«ã¢ããïŒâïŒâïŒïŒâãããã³âïŒ
âã€ã«ïŒããããªã³é ž3.7ïœãåŸããèç¹270ã
271.5âïŒåè§£ïŒ å®æœäŸ ïŒ ãšã¿ããŒã«100mlã«ãšãã«ïœâã¯ãã«ãã³ãŸãš
ãŒã1.66ïœããããªãŠã ãšãã©ãŒã0.5ïœããã³
ïŒâã¢ããâïŒâïŒïŒâãããã³âïŒâã€ã«ïŒã
ãããªã³é ž2.09ïœãå ããŠãªãŒãã¯ã¬ãŒãäžã
110æ°å§ã140ã150âã«ãŠïŒæéåå¿ããããå·
åŸãåå¿æ¶²ãæžå§äžæ¿çž®ããæ®æž£ãã¯ãããã«ã
200mlã«æº¶è§£ãããïŒïŒ çé žã«ãªãŠã 氎溶液ãåž
å¡©é žããã³æ°Žã§é 次æŽæµåŸãç¡«é žãããªãŠã ã§ä¹Ÿ
ç¥ãã溶åªãçå»ãããšã¿ããŒã«æ°Žããåçµæ¶ã
ãŠãçœè²ç²æ«ç¶ã®ïŒâïŒïŒâã¯ãã«ãã³ãŸã€ã«ã¢
ããïŒâïŒâïŒïŒâãããã³âïŒâã€ã«ïŒããããª
ã³é ž300mgãåŸããèç¹270ã271.5âïŒåè§£ïŒ å®æœäŸ ïŒã32 å®æœäŸïŒãšåæ§ã«ããŠãé©åœãªåºçºåæãçšã
ãŠã次衚ã®ååç©ãåŸãã
âïŒïŒâãããã³âïŒâã€ã«ïŒããããªããŒãïŒ
ïœã«20ïŒ å¡©é ž150mlãå ããŠïŒæééæµãè¡ãªãã
æžå§æ¿çž®ããæ®æž£ããšã¿ããŒã«âæ°Žããåçµæ¶ã
ãŠç¡è²ããªãºã ç¶ã®ïŒâã¢ããâïŒâïŒïŒâãã
ãã³âïŒâã€ã«ïŒããããªã³é žå¡©é žå¡©äžæ°Žåç©
3.2ïœãåŸããèç¹220ã225âïŒåè§£ïŒ å®æœäŸ ïŒ ïŒâã¢ããâïŒâïŒïŒâãããã³âïŒâã€ã«ïŒ
ããããªã³é žå¡©é žå¡©1.6ïœãšçé žã«ãªãŠã 2.4ïœãš
ãã¢ã»ãã³60mlãšæ°Ž30mlãšã«æº¶è§£ãããããã«æ°·
å·æ¹æããªããå¡©åïœâã¯ãã«ãã³ãŸã€ã«1.2ïœ
ã®ã¢ã»ãã³10ml溶液ã滎äžãããæ°·å·äžïŒæéæ¹
æãããã¢ã»ãã³ãçå»åŸãæ®æž£ã«æ°Žãå ããŠäž
溶ç©ãå»ããã液ãå¡©é žã§é žæ§ãšããæåºçµ
æ¶ãåããããšã¿ããŒã«âæ°Žããåçµæ¶ããŠã
çœè²ç²æ«ç¶ã®ïŒâïŒïŒâã¯ãã«ãã³ãŸã€ã«ã¢ããïŒ
âïŒâïŒïŒâãããã³âïŒâã€ã«ïŒããããªã³é ž
1.5ïœãåŸããèç¹270ã271.5âïŒåè§£ïŒ å®æœäŸ ïŒ ïŒâã¢ããâïŒâïŒïŒâã¡ããã·âïŒâããã
ã³âïŒâã€ã«ïŒããããªã³é žå¡©é žå¡©1.5ïœãæ°Žé ž
åãããªãŠã 0.8ïœã®æ°Ž25ml溶液ã«æº¶è§£ãããæ°·
å·äžå¡©åïœâã¯ãã«ãã³ãŸã€ã«ïŒïœã滎äžããæ¹
æãããèå±€ã¯ãããã°ã©ãã€ã«ããåæãæ¶å€±
ãããŸã§ïŒ®âæ°Žé žåãããªãŠã 氎溶液ããã³é žã¯
ããªããé©æå ãããåå¿çµäºåŸãå¡©é žé žæ§ãš
ããæåºæ¶ãåããããšãŒãã«ã§æŽæµããã®
ã¡ãã¡ã¿ããŒã«âæ°Žããåçµæ¶ããŠãé»è²ç²æ«ç¶
ã®ïŒâïŒïŒâã¯ãã«ãã³ãŸã€ã«ã¢ããïŒâïŒâïŒïŒ
âã¡ããã·âïŒâãããã³âïŒâã€ã«ïŒããããª
ã³é ž0.7ïœãåŸããèç¹234.5ã236âïŒåè§£ïŒ å®æœäŸ ïŒ ïŒâã¢ããâïŒâïŒïŒâããããã·âïŒâãã
ãã³âïŒâã€ã«ïŒããããªã³é žå¡©é žå¡©ïŒïœãïŒâ
ã¡ãã«âïŒâãããªãã³50mlã«æžæ¿ããïŒâïŒïŒ
âã¯ãã«ãã³ãŸã€ã«ïŒãã³ãºãªããµãŸãªã³âïŒâ
ããªã³2.2ïœãå ããŠå®€æž©ã§ïŒæ¥éæ¹æãããå
å¿æ¶²ãæ°·æ°Žã«ãããŠãæåºæ¶ãåãããçµæ¶ã
âæ°Žé žåãããªãŠã 氎溶液ã«æº¶è§£åŸã10ïŒ å¡©é ž
ã§é žæ§ãšããæåºæ¶ãåãããçµæ¶ã也ç¥åŸã
ã¯ãããã«ã ã§æŽæµãããã¡ã¿ããŒã«âæ°Žããå
çµæ¶ããŠæ·¡é»è²ç²æ«ç¶ã®ïŒâïŒïŒâã¯ãã«ãã³ãŸ
ã€ã«ã¢ããïŒâïŒâïŒïŒâããããã·âïŒâããã
ã³âïŒâã€ã«ïŒããããªã³é ž1.5ïœãåŸããèç¹
223ã227âïŒåè§£ïŒ å®æœäŸ ïŒ ïŒâã¢ããâïŒâïŒïŒâãããã³âïŒâã€ã«ïŒ
ããããªã³é ž1.2ïœãDCC1.3ïœããã³ïœâã¯ãã«
å®æ¯éŠé ž1.0ïœããžãªããµã³10mlã«æžæ¿ããã60
ã70âã§ïŒæéæ¹æãããåå¿çµäºåŸã溶åªãç
å»ãããšãŒãã«ãå ããŠæåºæ¶ãå»ããã液
ãæ¿çž®åŸãæ®æž£ã«ã¯ãããã«ã ãå ããŠæº¶è§£ãã
æ°Žããã³é£œåé£å¡©æ°Žã§æŽæµãããç¡«é žãããªãŠã
ã§ä¹Ÿç¥åŸã溶åªãçå»ããããšã¿ããŒã«âæ°Žãã
åçµæ¶ããŠãçœè²ç²æ«ç¶ã®ïŒâïŒïŒâã¯ãã«ãã³
ãŸã€ã«ã¢ããïŒâïŒâïŒïŒâãããã³âïŒâã€ã«ïŒ
ããããªã³é ž350mgãåŸãã èç¹270ã271.5âïŒåè§£ïŒ å®æœäŸ ïŒ ïŒâã¢ããâïŒâïŒïŒâãããã³âïŒâã€ã«ïŒ
ããããªã³é ž1.2ïœããã³ããªãšãã«ã¢ãã³0.8ml
ãããã©ããããã©ã³10mlã«æžæ¿ããã宀枩æ¹æ
äžã«ãžãšãã«ã¯ãããã¹ããšãŒã1.0ïœã®ããã©
ããããã©ã³10ml溶液ã滎äžãã宀枩ã§ïŒæéæ¹
æããããã®ãã®ã«ïœâã¯ãã«å®æ¯éŠé ž1.0ïœã®
ããã©ããããã©ã³10ml溶液ã滎äžãã宀枩ã§ã
ãã«10æéæ¹æãããåå¿çµäºåŸãæåºæ¶ãå»
ãã液ãæ¿çž®ããŠãæ®æž£ã«é£œåéãœãŠã泚ãã
ã¯ãããã«ã æœåºãããææ©å±€ãæ°Žããã³é£œåé£
å¡©æ°Žã§æŽæµããç¡«é žãããªãŠã ã§ä¹Ÿç¥åŸã溶åªã
çå»ããããšã¿ããŒã«âæ°Žããåçµæ¶ããŠãçœè²
ç²æ«ç¶ã®ïŒâïŒïŒâã¯ãã«ãã³ãŸã€ã«ã¢ããïŒâïŒ
âïŒïŒâãããã³âïŒâã€ã«ïŒããããªã³é ž0.9ïœ
ãåŸããèç¹270ã271.5âïŒåè§£ïŒ å®æœäŸ ïŒ ïœâã¯ãã«å®æ¯éŠé ž4.84ïœããã³ããªãšãã«ã¢
ãã³ïŒmlã®ãžã¡ãã«ãã«ã ã¢ãã50ml溶液ã«ãã€
ãœããã«ã¯ãããã«ã¡ãŒã3.87ïœã®ãžã¡ãã«ãã«
ã ã¢ããïŒml溶液ã滎äžããã宀枩ã§30åéæ¹æ
åŸãïŒâã¢ããâïŒâïŒïŒâãããã³âïŒâã€ã«ïŒ
ããããªã³é ž6.03ïœã®ãžã¡ãã«ãã«ã ã¢ããïŒml
溶液ã滎äžãã宀枩ã§30åãç¶ããŠ50ã60âã§ïŒ
æéæ¹æãããåå¿æ··åç©ãå€éã®é£œåé£å¡©æ°Žã«
泚ã蟌ã¿ãã¯ãããã«ã æœåºããæ°ŽæŽåŸä¹Ÿç¥ã
ãã溶åªãçå»ããŠåŸãããç²çµæ¶ããšã¿ããŒã«
âæ°Žããåçµæ¶ããŠãçœè²ç²æ«ç¶ã®ïŒâïŒïŒâã¯
ãã«ãã³ãŸã€ã«ã¢ããïŒâïŒâïŒïŒâãããã³âïŒ
âã€ã«ïŒããããªã³é ž3.7ïœãåŸããèç¹270ã
271.5âïŒåè§£ïŒ å®æœäŸ ïŒ ãšã¿ããŒã«100mlã«ãšãã«ïœâã¯ãã«ãã³ãŸãš
ãŒã1.66ïœããããªãŠã ãšãã©ãŒã0.5ïœããã³
ïŒâã¢ããâïŒâïŒïŒâãããã³âïŒâã€ã«ïŒã
ãããªã³é ž2.09ïœãå ããŠãªãŒãã¯ã¬ãŒãäžã
110æ°å§ã140ã150âã«ãŠïŒæéåå¿ããããå·
åŸãåå¿æ¶²ãæžå§äžæ¿çž®ããæ®æž£ãã¯ãããã«ã
200mlã«æº¶è§£ãããïŒïŒ çé žã«ãªãŠã 氎溶液ãåž
å¡©é žããã³æ°Žã§é 次æŽæµåŸãç¡«é žãããªãŠã ã§ä¹Ÿ
ç¥ãã溶åªãçå»ãããšã¿ããŒã«æ°Žããåçµæ¶ã
ãŠãçœè²ç²æ«ç¶ã®ïŒâïŒïŒâã¯ãã«ãã³ãŸã€ã«ã¢
ããïŒâïŒâïŒïŒâãããã³âïŒâã€ã«ïŒããããª
ã³é ž300mgãåŸããèç¹270ã271.5âïŒåè§£ïŒ å®æœäŸ ïŒã32 å®æœäŸïŒãšåæ§ã«ããŠãé©åœãªåºçºåæãçšã
ãŠã次衚ã®ååç©ãåŸãã
ãè¡šã
ãè¡šã
å®æœäŸ 33
ïŒâã¢ããâïŒâïŒïŒâãšãã«âïŒâãããã³
âïŒâã€ã«ïŒããããªã³é žå¡©é žå¡©3.0ïœãšçé žã«
ãªãŠã 5.5ïœãšãã¢ã»ãã³100mlãšæ°Ž50mlãšã«æº¶è§£
ãããããã«ãæ°·å·æ¹æäžãå¡©åïœâã¯ãã«ãã³
ãŸã€ã«2.2ïœã滎äžããïŒæéæ¹æãããã¢ã»ã
ã³ãçå»åŸãæ®çç©ãæ°Žã§ããããŠå¡©é žã§é žæ§ãš
ãããæåºæ¶ããšã¿ããŒã«âæ°Žããåçµæ¶ããã®
ã¡ãæ°Žé žåãããªãŠã ïŒïœãå«ãã¡ã¿ããŒã«100
mlãšæ°Ž50mlã«æº¶è§£ãããæ¿å¡©é žã§é žæ§ãšããå·èµ
庫ã«æŸçœ®ãããæåºæ¶ãåããŠçœè²ç²æ«ã®ïŒâ
ïŒïŒâã¯ãã«ãã³ãŸã€ã«ã¢ããïŒâïŒâïŒïŒâãšã
ã«âïŒâãããã³âïŒâã€ã«ïŒããããªã³é žæ°Žå
ç©2.4ïœãåŸããèç¹263ã264.5âïŒå解ïŒã
NMRïŒDMSOïŒÎŽïŒ1.17ïŒ3H.t.JïŒïŒHzïŒã3.00ã
3.70ïŒ2HïŒïœïŒã4.18ïŒ2HïŒïœïŒïŒªïŒïŒHzïŒã4.50
ã5.80ïŒ1HïŒïœïŒã6.53ïŒ1HïŒïœïŒã7.10ã8.00
ïŒ8HïŒïœïŒã8.88ïŒ1HïŒïœïŒïŒªïŒ7.5HzïŒ å®æœäŸ 34ã127 å®æœäŸïŒããã³ïŒãïŒãšåæ§ã«ããŠé©åœãªåºçº
åæãçšããŠæ¬¡è¡šã®ååç©ãåŸãã
âïŒâã€ã«ïŒããããªã³é žå¡©é žå¡©3.0ïœãšçé žã«
ãªãŠã 5.5ïœãšãã¢ã»ãã³100mlãšæ°Ž50mlãšã«æº¶è§£
ãããããã«ãæ°·å·æ¹æäžãå¡©åïœâã¯ãã«ãã³
ãŸã€ã«2.2ïœã滎äžããïŒæéæ¹æãããã¢ã»ã
ã³ãçå»åŸãæ®çç©ãæ°Žã§ããããŠå¡©é žã§é žæ§ãš
ãããæåºæ¶ããšã¿ããŒã«âæ°Žããåçµæ¶ããã®
ã¡ãæ°Žé žåãããªãŠã ïŒïœãå«ãã¡ã¿ããŒã«100
mlãšæ°Ž50mlã«æº¶è§£ãããæ¿å¡©é žã§é žæ§ãšããå·èµ
庫ã«æŸçœ®ãããæåºæ¶ãåããŠçœè²ç²æ«ã®ïŒâ
ïŒïŒâã¯ãã«ãã³ãŸã€ã«ã¢ããïŒâïŒâïŒïŒâãšã
ã«âïŒâãããã³âïŒâã€ã«ïŒããããªã³é žæ°Žå
ç©2.4ïœãåŸããèç¹263ã264.5âïŒå解ïŒã
NMRïŒDMSOïŒÎŽïŒ1.17ïŒ3H.t.JïŒïŒHzïŒã3.00ã
3.70ïŒ2HïŒïœïŒã4.18ïŒ2HïŒïœïŒïŒªïŒïŒHzïŒã4.50
ã5.80ïŒ1HïŒïœïŒã6.53ïŒ1HïŒïœïŒã7.10ã8.00
ïŒ8HïŒïœïŒã8.88ïŒ1HïŒïœïŒïŒªïŒ7.5HzïŒ å®æœäŸ 34ã127 å®æœäŸïŒããã³ïŒãïŒãšåæ§ã«ããŠé©åœãªåºçº
åæãçšããŠæ¬¡è¡šã®ååç©ãåŸãã
ãè¡šã
Claims (1)
- ãç¹èš±è«æ±ã®ç¯å²ã ïŒ äžè¬åŒ K0006 åŒäžãR1ã¯æ°ŽçŽ ååãäœçŽã¢ã«ãã«åºãäœ
çŽã¢ã«ã±ãã«åºãäœçŽã¢ã«ããã«åºãŸãã¯ããšã
ã«äœçŽã¢ã«ãã«åºïŒR2ã¯æ°ŽçŽ ååãæ°Žé žåºãäœ
çŽã¢ã«ãã«åºãŸãã¯äœçŽã¢ã«ã³ãã·åºïŒR3ã¯æ°Ž
é žåºãã·ã¯ãã¢ã«ãã«ç°äžã«çœ®æåºãæããã·ã¯
ãã¢ã«ãã«äœçŽã¢ã«ãã«ã¢ããåºïŒè©²ã·ã¯ãã¢ã«
ãã«ç°äžã®çœ®æåºã¯ã«ã«ããã·åºãŸãã¯äœçŽã¢ã«
ã³ãã·ã«ã«ããã«åºã§ããïŒïŒR4ã¯æ°ŽçŽ ååãŸã
ã¯åºâCOR6ïŒR6ã¯çœ®æåºãšããŠã¢ããäœçŽã¢ã«
ãã«åºãæããããšã®ããã·ã¯ãã¢ã«ãã«åºãã
ãšãã«ç°äžã«çœ®æåºãšããŠããã²ã³ååãäœçŽã¢
ã«ãã«åºãäœçŽã¢ã«ã³ãã·åºããããåºãæ°Žé žåº
ããã³ã¢ããåºããéžã°ããåºã®ïŒãïŒåãæã
ãããšã®ããããšãã«åºãããšãã«ç°äžã«çœ®æåº
ãšããŠããã²ã³ååãæããããšã®ããããšãã«
äœçŽã¢ã«ãã«åºããŸãã¯äœçŽã¢ã«ãã«ãã¢ãŸãªã«
åºãããªãžã«åºãŸãã¯ããªã«åºããéžã°ããäžé£œ
åè€çŽ ç°åºïŒïŒR5ã¯æ°ŽçŽ ååãŸãã¯çœ®æåºãšããŠ
ããã²ã³ååãæããããšãã«ã¹ã«ããã«åºïŒïŒ¡
ã¯äœçŽã¢ã«ãã¬ã³åºïŒïœã¯ïŒã瀺ãã眮æåºã®åŒ
ãåŒãã«ãããâCHã ã¯âCHïŒïŒ£ãŸãã¯âCH2âCHãæå³ãã
ãã€ãã®çœ®æåºã®çœ®æäœçœ®ã¯ã«ã«ãã¹ããªã«éªšæ Œ
ã®ïŒïŒïŒïŒïŒãŸãã¯ïŒäœã®ããããã§ããããŸã
ã«ã«ãã¹ããªã«éªšæ Œã®ïŒäœãšïŒäœéã®çµåã¯äžé
çµåãŸãã¯äºéçµåã瀺ãã ã§ç€ºãããã«ã«ãã¹ããªã«èªå°äœãŸãã¯ãã®å¡©ã
掻æ§æåãšããŠå«æããããšãç¹åŸŽãšããæ朰ç
å€ã ïŒ è©²æŽ»æ§æåããåŒ K0008 瀺ãããååç©ã§ããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒ
ã®æ朰çå€ã
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP58126498A JPS6019767A (ja) | 1983-07-11 | 1983-07-11 | ã«ã«ãã¹ããªã«èªå°äœãæå¹æåãšããæ朰çå€ |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP58126498A JPS6019767A (ja) | 1983-07-11 | 1983-07-11 | ã«ã«ãã¹ããªã«èªå°äœãæå¹æåãšããæ朰çå€ |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1109540A Division JPH01308258A (ja) | 1989-04-27 | 1989-04-27 | ã«ã«ãã¹ããªã«èªå°äœ |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS6019767A JPS6019767A (ja) | 1985-01-31 |
JPH0261923B2 true JPH0261923B2 (ja) | 1990-12-21 |
Family
ID=14936690
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP58126498A Granted JPS6019767A (ja) | 1983-07-11 | 1983-07-11 | ã«ã«ãã¹ããªã«èªå°äœãæå¹æåãšããæ朰çå€ |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6019767A (ja) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2812998B2 (ja) * | 1989-08-14 | 1998-10-22 | 倧å¡è£œè¬ æ ªåŒäŒç€Ÿ | èçæ²»çå€ |
KR100818965B1 (ko) * | 2000-10-02 | 2008-04-04 | ììŒ íë§ìí°ì¹Ž ì.ëžìŽ. | ëì¬ìê·¹ì± êžë£šíë©ìŽíž ìì©ì²Ž êžžíì |
KR100669823B1 (ko) | 2001-02-20 | 2007-01-17 | 겜ëì ìœ ì£Œìíì¬ | 2-(4-íŽë¡ë¡ë²€ì¡°ìŒìë¯žë ž)-3-[2(1ïœ)-íŽëëŠ¬ë Œ-4-ìŒ]íë¡íŒìšì°ì ì ì¡°ë°©ë² ë° ê·ž ì€ê°ì²Ž |
US7718805B2 (en) | 2004-12-01 | 2010-05-18 | Otsuka Pharmaceutical Co., Ltd. | Process for preparing rebamipide |
JP3892894B2 (ja) | 2005-04-28 | 2007-03-14 | 倧å¡è£œè¬æ ªåŒäŒç€Ÿ | ã«ã«ãã¹ããªã«ååç©ã®è£œé æ³ |
CN102153512B (zh) * | 2011-03-07 | 2013-03-27 | æ±è¥¿ååè¯äžæéèŽ£ä»»å ¬åž | ç巎掟ç¹äžéŽäœçå¶å€æ¹æ³ |
SA113340675B1 (ar) | 2012-06-26 | 2015-08-16 | استÙØŽ. ÙÙ.Ø ÙÙ٠تد | أدÙÙØ© رÙؚا٠ÙؚاÙد تØضÙرÙØ© جدÙØ¯Ø©Ø Ø·Ø±ÙÙØ© تØضÙرÙا Ùاستخدا٠Ùا |
CN103113294B (zh) * | 2013-03-11 | 2016-04-27 | æµæ±è¿åå¥è¯äžæéèŽ£ä»»å ¬åž | ç巎掟ç¹çåææ¹æ³ |
KR102132162B1 (ko) * | 2013-12-25 | 2020-07-10 | ìŒì§ì ìœì£Œìíì¬ | ì ê· ë ë°ë¯žíŒë ì 구첎ì ìŒ ë° ìŽì ì©ë |
-
1983
- 1983-07-11 JP JP58126498A patent/JPS6019767A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6019767A (ja) | 1985-01-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2005278962B2 (en) | Isoindolin-1-one derivatives | |
US5767283A (en) | 7-Amino-1H-indoles | |
US5708020A (en) | Arylalkyl(thio)amides | |
JPS6293274A (ja) | æ°èŠã¢ããèªå°äœåã³ãã®è£œæ³ | |
US5506252A (en) | Substituted N-heteroaryl and N-aryl-1,2-diaminocyclobutene-3,4-diones | |
DE3324034A1 (de) | Carbostyrilderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten | |
IE913477A1 (en) | Indole derivatives as antiallergy and antiinflammatory agents | |
KR20000064716A (ko) | ìœíì ìŒë¡ì ì©ííí©ë¬Œ | |
JP2009512670A (ja) | ççã®æ²»çã«æçšãªãã©ãŸãŒã«ååç© | |
GB2177393A (en) | Benzimidazole derivatives | |
JPH0261923B2 (ja) | ||
JPS6320226B2 (ja) | ||
NZ224240A (en) | Indole and isoindoline derivatives, preparation and pharmaceutical compositions thereof | |
KR20010102580A (ko) | ëŽë¡í€ë-1 ìì©ì²Ž êžžíì ë¡ììïœ-(2-íë-4-ìë¯žë ž-ë¶íž)-1-ëíížì믞ë | |
JPH0564141B2 (ja) | ||
JPS6335623B2 (ja) | ||
US5354864A (en) | 3-(9-acridinylamino)-5-hydroxymethylaniline derivatives as anticancer agents | |
JPH059429B2 (ja) | ||
US20090088463A1 (en) | Pyrazoles Useful in the Treatment of Inflammation | |
JPS63141969A (ja) | æ°èŠã€ãããŸâã«èªå°äœ | |
JPH0328425B2 (ja) | ||
JPH0565273A (ja) | ã«ã«ãã¹ããªã«èªå°äœ | |
CZ365192A3 (en) | Cyclic derivatives of aminophenylacetic acid, process of their preparation and medicaments based thereon | |
CA2111460C (en) | Tetrahydrobenzazepine derivatives which inhibit lipoxygenase | |
JP2961291B2 (ja) | ãã³ãŸãããç°ååç© |