JPH0254821B2 - - Google Patents

Info

Publication number
JPH0254821B2
JPH0254821B2 JP58009484A JP948483A JPH0254821B2 JP H0254821 B2 JPH0254821 B2 JP H0254821B2 JP 58009484 A JP58009484 A JP 58009484A JP 948483 A JP948483 A JP 948483A JP H0254821 B2 JPH0254821 B2 JP H0254821B2
Authority
JP
Japan
Prior art keywords
urea
benzyl
formula
alkyl
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP58009484A
Other languages
English (en)
Japanese (ja)
Other versions
JPS58134070A (ja
Inventor
Goodon Deburiizu Baan
Yuujin Raajisu Erutsudo
Buraun Konroo Ransamu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of JPS58134070A publication Critical patent/JPS58134070A/ja
Publication of JPH0254821B2 publication Critical patent/JPH0254821B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP58009484A 1982-01-26 1983-01-25 置換尿素及びチオ尿素化合物 Granted JPS58134070A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US342693 1982-01-26
US06/342,693 US4473579A (en) 1982-01-26 1982-01-26 Antiatherosclerotic tetrasubstituted ureas and thioureas
US342698 1982-01-26

Publications (2)

Publication Number Publication Date
JPS58134070A JPS58134070A (ja) 1983-08-10
JPH0254821B2 true JPH0254821B2 (enExample) 1990-11-22

Family

ID=23342884

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58009484A Granted JPS58134070A (ja) 1982-01-26 1983-01-25 置換尿素及びチオ尿素化合物

Country Status (6)

Country Link
US (1) US4473579A (enExample)
JP (1) JPS58134070A (enExample)
BE (1) BE895708A (enExample)
CA (1) CA1291990C (enExample)
PH (1) PH18706A (enExample)
ZA (1) ZA83484B (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4623662A (en) 1985-05-23 1986-11-18 American Cyanamid Company Antiatherosclerotic ureas and thioureas
US5003106A (en) * 1983-07-19 1991-03-26 American Cyanamid Company Antiatherosclerotic ureas and thioureas
DE3636190A1 (de) * 1986-10-24 1988-04-28 Bayer Ag Verfahren zur herstellung von n,n-diaryl-harnstoffen
US4782071A (en) * 1986-11-03 1988-11-01 Warner-Lambert Company Tetrasubstituted urea cholinergic agents
ATE61574T1 (de) * 1987-07-02 1991-03-15 Warner Lambert Co N-((2,6-disubstituierte)-phenyl>-harnstoff und - carbamat-inhibitoren der acyl-coenzym a:cholesterol-acyltransferase.
CN1021819C (zh) * 1988-01-20 1993-08-18 山之内制药株式会社 作为药物有用的双脲衍生物的制备方法
US4868210A (en) * 1988-03-30 1989-09-19 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic compounds and compositions
US4999373A (en) * 1988-03-30 1991-03-12 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic compounds and compositions
US5116848A (en) * 1988-03-30 1992-05-26 Warner-Lambert Company N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents
US5290814A (en) * 1988-11-21 1994-03-01 Burroughs Wellcome Co. Anti-atherosclerotic diaryl compounds
DE3920616A1 (de) * 1989-06-23 1991-01-03 Boehringer Mannheim Gmbh Arzneimittel, enthaltend di-tert.-butylhydroxyphenyl-derivate sowie neue derivate
JPH05310678A (ja) * 1990-01-22 1993-11-22 Mitsubishi Kasei Corp １−フェニルアルキル−３−フェニル尿素誘導体
ES2068497T3 (es) * 1990-03-12 1995-04-16 Yamanouchi Pharma Co Ltd Derivados de urea, su produccion, y composiciones farmaceuticas que los contienen.
US5106873A (en) * 1990-06-26 1992-04-21 Warner-Lambert Company ACAT inhibitors
US5362878A (en) * 1991-03-21 1994-11-08 Pfizer Inc. Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT)
US5401825A (en) * 1993-05-05 1995-03-28 Gould Inc. Styrene type monomers containing substituents thereon, e.g. urea, and polymers and copolymers thereof
US6344476B1 (en) 1997-05-23 2002-02-05 Bayer Corporation Inhibition of p38 kinase activity by aryl ureas
US6187799B1 (en) * 1997-05-23 2001-02-13 Onyx Pharmaceuticals Inhibition of raf kinase activity using aryl ureas
US20080300281A1 (en) * 1997-12-22 2008-12-04 Jacques Dumas Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas
US7517880B2 (en) 1997-12-22 2009-04-14 Bayer Pharmaceuticals Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
US7329670B1 (en) 1997-12-22 2008-02-12 Bayer Pharmaceuticals Corporation Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
US20080269265A1 (en) * 1998-12-22 2008-10-30 Scott Miller Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas
ME00275B (me) * 1999-01-13 2011-02-10 Bayer Corp ω-KARBOKSIARIL SUPSTITUISANI DIFENIL KARBAMIDI KAO INHIBITORI RAF KINAZE
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US7928239B2 (en) 1999-01-13 2011-04-19 Bayer Healthcare Llc Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas
EP1140840B1 (en) 1999-01-13 2006-03-22 Bayer Pharmaceuticals Corp. -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
EP2298311B1 (en) 1999-01-13 2012-05-09 Bayer HealthCare LLC w-Carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors
AU7353300A (en) 1999-09-08 2001-04-10 Guilford Pharmaceuticals Inc. Non-peptidic cyclophilin binding compounds and their use
US7235576B1 (en) 2001-01-12 2007-06-26 Bayer Pharmaceuticals Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
EP1360173A2 (en) 2001-01-25 2003-11-12 Guilford Pharmaceuticals Inc. Trisubstituted carbocyclic cyclophilin binding compounds and their use
US7371763B2 (en) * 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
MXPA04005137A (es) * 2001-12-03 2005-06-03 Bayer Pharmaceuticals Corp Compuestos de aril urea en combinacion con otros agentes citostaticos para el tratamiento de canceres humanos.
DK1580188T3 (da) 2002-02-11 2012-02-06 Bayer Healthcare Llc Forbindelser af arylurea som kinaseinhibitorer
AU2003209119A1 (en) * 2002-02-11 2003-09-04 Bayer Pharmaceuticals Corporation Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors
ES2425739T3 (es) 2002-02-11 2013-10-17 Bayer Healthcare Llc Sorafenib-tosilato para el tratamiento de enfermedades caracterizadas por angiogénesis anormal
EP1533292B1 (en) * 2002-08-30 2007-02-14 Japan Tobacco Inc. Dibenzylamine compound and medicinal use thereof
US7557129B2 (en) 2003-02-28 2009-07-07 Bayer Healthcare Llc Cyanopyridine derivatives useful in the treatment of cancer and other disorders
CA2526636C (en) * 2003-05-20 2012-10-02 Bayer Pharmaceuticals Corporation Diaryl ureas for diseases mediated by pdgfr
BR122016015715B8 (pt) 2003-07-23 2021-05-25 Bayer Healthcare Llc composições farmacêuticas de metilamida de ácido 4[4-[3-(4-cloro-3-trifluorometilfenil)-ureido]-3-fluorofenóxi)-piridina-2-carboxílico

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL212631A (enExample) * 1949-12-06
US2867520A (en) * 1956-11-23 1959-01-06 Monsanto Chemicals 1-(chloraryl) 3-alkyl 3-alkynyl urea
US2993930A (en) * 1958-03-18 1961-07-25 Midwest Research Inst Tetra-substituted ureas
US3277061A (en) * 1963-07-01 1966-10-04 Union Oil Co Carbonylation of amines and substituted ureas derived therefrom
US3326663A (en) * 1964-09-25 1967-06-20 Shell Oil Co Herbicidal phenylureas
FR1471681A (enExample) * 1965-03-25 1967-05-25
US3897493A (en) * 1971-09-13 1975-07-29 Stauffer Chemical Co Meta-anilide urea compositions and their utility as herbicides
JPS5224104B2 (enExample) * 1974-10-07 1977-06-29
JPS5312844A (en) * 1976-07-20 1978-02-04 Nippon Tokushu Noyaku Seizo Kk Nn44halogenobenzyllnnmethyl*or nonsubstitutedd*cycloalkylln**phenylurea or thiourea compounds* their preparation and fungicides containing the same as active constituents
DE3027253C2 (de) * 1980-07-18 1982-11-04 Degussa Ag, 6000 Frankfurt Verfahren zur Herstellung von Wasserstoffperoxid
JPS6032447A (ja) * 1983-08-03 1985-02-19 Nec Corp 群別２線式搬送回線の折返し回路

Also Published As

Publication number Publication date
JPS58134070A (ja) 1983-08-10
PH18706A (en) 1985-09-05
BE895708A (fr) 1983-07-26
ZA83484B (en) 1983-10-26
CA1291990C (en) 1991-11-12
US4473579A (en) 1984-09-25

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