ZA83484B - Antiatherosclerotic substituted ureas and thioureas - Google Patents
Antiatherosclerotic substituted ureas and thioureasInfo
- Publication number
- ZA83484B ZA83484B ZA83484A ZA83484A ZA83484B ZA 83484 B ZA83484 B ZA 83484B ZA 83484 A ZA83484 A ZA 83484A ZA 83484 A ZA83484 A ZA 83484A ZA 83484 B ZA83484 B ZA 83484B
- Authority
- ZA
- South Africa
- Prior art keywords
- antiatherosclerotic
- thioureas
- substituted ureas
- ureas
- substituted
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/342,693 US4473579A (en) | 1982-01-26 | 1982-01-26 | Antiatherosclerotic tetrasubstituted ureas and thioureas |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA83484B true ZA83484B (en) | 1983-10-26 |
Family
ID=23342884
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA83484A ZA83484B (en) | 1982-01-26 | 1983-01-25 | Antiatherosclerotic substituted ureas and thioureas |
Country Status (6)
Country | Link |
---|---|
US (1) | US4473579A (xx) |
JP (1) | JPS58134070A (xx) |
BE (1) | BE895708A (xx) |
CA (1) | CA1291990C (xx) |
PH (1) | PH18706A (xx) |
ZA (1) | ZA83484B (xx) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4623662A (en) | 1985-05-23 | 1986-11-18 | American Cyanamid Company | Antiatherosclerotic ureas and thioureas |
US5003106A (en) * | 1983-07-19 | 1991-03-26 | American Cyanamid Company | Antiatherosclerotic ureas and thioureas |
DE3636190A1 (de) * | 1986-10-24 | 1988-04-28 | Bayer Ag | Verfahren zur herstellung von n,n-diaryl-harnstoffen |
US4782071A (en) * | 1986-11-03 | 1988-11-01 | Warner-Lambert Company | Tetrasubstituted urea cholinergic agents |
EP0297610B1 (en) * | 1987-07-02 | 1991-03-13 | Warner-Lambert Company | N-[(2,6-disubstituted)phenyl]-urea and carbamate inhibitors of acyl-CoA:cholesterol acyl-transferase |
CN1021819C (zh) * | 1988-01-20 | 1993-08-18 | 山之内制药株式会社 | 作为药物有用的双脲衍生物的制备方法 |
US4868210A (en) * | 1988-03-30 | 1989-09-19 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic compounds and compositions |
US4999373A (en) * | 1988-03-30 | 1991-03-12 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic compounds and compositions |
US5116848A (en) * | 1988-03-30 | 1992-05-26 | Warner-Lambert Company | N-(((2,6-disubstituted)phenyl)-n-diarylalkyl)ureas as antihyperlipidemic and antiatherosclerotic agents |
US5290814A (en) * | 1988-11-21 | 1994-03-01 | Burroughs Wellcome Co. | Anti-atherosclerotic diaryl compounds |
DE3920616A1 (de) * | 1989-06-23 | 1991-01-03 | Boehringer Mannheim Gmbh | Arzneimittel, enthaltend di-tert.-butylhydroxyphenyl-derivate sowie neue derivate |
JPH05310678A (ja) * | 1990-01-22 | 1993-11-22 | Mitsubishi Kasei Corp | 1−フェニルアルキル−3−フェニル尿素誘導体 |
DE69105786T2 (de) * | 1990-03-12 | 1995-04-27 | Yamanouchi Pharma Co Ltd | Harnstoffderivate, deren Herstellung sowie diese enthaltende pharmazeutische Zusammensetzungen. |
US5106873A (en) * | 1990-06-26 | 1992-04-21 | Warner-Lambert Company | ACAT inhibitors |
US5362878A (en) * | 1991-03-21 | 1994-11-08 | Pfizer Inc. | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) |
US5401825A (en) * | 1993-05-05 | 1995-03-28 | Gould Inc. | Styrene type monomers containing substituents thereon, e.g. urea, and polymers and copolymers thereof |
US6344476B1 (en) | 1997-05-23 | 2002-02-05 | Bayer Corporation | Inhibition of p38 kinase activity by aryl ureas |
US6187799B1 (en) * | 1997-05-23 | 2001-02-13 | Onyx Pharmaceuticals | Inhibition of raf kinase activity using aryl ureas |
US7329670B1 (en) * | 1997-12-22 | 2008-02-12 | Bayer Pharmaceuticals Corporation | Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas |
US20080300281A1 (en) * | 1997-12-22 | 2008-12-04 | Jacques Dumas | Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas |
US7517880B2 (en) | 1997-12-22 | 2009-04-14 | Bayer Pharmaceuticals Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
US20080269265A1 (en) * | 1998-12-22 | 2008-10-30 | Scott Miller | Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas |
RU2319693C9 (ru) * | 1999-01-13 | 2008-08-20 | Байер Копэрейшн | Производные мочевины (варианты), фармацевтическая композиция (варианты) и способ лечения заболевания, связанного с ростом раковых клеток (варианты) |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
WO2000042012A1 (en) | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS |
US7928239B2 (en) | 1999-01-13 | 2011-04-19 | Bayer Healthcare Llc | Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas |
EP1158985B1 (en) | 1999-01-13 | 2011-12-28 | Bayer HealthCare LLC | OMEGA-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS |
JP2003508512A (ja) | 1999-09-08 | 2003-03-04 | ギルフォード ファーマシュウティカルズ インコーポレイテッド | 非ペプチド性サイクロフィリン結合化合物とその用途 |
US7235576B1 (en) | 2001-01-12 | 2007-06-26 | Bayer Pharmaceuticals Corporation | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
EP1360173A2 (en) | 2001-01-25 | 2003-11-12 | Guilford Pharmaceuticals Inc. | Trisubstituted carbocyclic cyclophilin binding compounds and their use |
US7371763B2 (en) * | 2001-04-20 | 2008-05-13 | Bayer Pharmaceuticals Corporation | Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas |
ES2275931T5 (es) * | 2001-12-03 | 2018-10-23 | Bayer Healthcare Llc | Compuestos de aril-urea en combinación con otros agentes citostáticos o citotóxicos para tratamiento de cánceres humanos |
ATE529406T1 (de) | 2002-02-11 | 2011-11-15 | Bayer Healthcare Llc | Aryl-harnstoffe als kinase inhibitoren |
AU2003209119A1 (en) | 2002-02-11 | 2003-09-04 | Bayer Pharmaceuticals Corporation | Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors |
WO2003068228A1 (en) | 2002-02-11 | 2003-08-21 | Bayer Pharmaceuticals Corporation | Aryl ureas with angiogenesis inhibiting activity |
PT1533292E (pt) * | 2002-08-30 | 2007-05-31 | Japan Tobacco Inc | Compostos de dibenzilamina e sua utilização farmacêutica. |
UY28213A1 (es) | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
MXPA05012486A (es) * | 2003-05-20 | 2006-07-03 | Bayer Pharmaceuticals Corp | Diaril ureas para enfermedades mediadas por pdgfr. |
UA84156C2 (ru) | 2003-07-23 | 2008-09-25 | Байер Фармасьютикалс Корпорейшн | Фторозамещённая омега-карбоксиарилдифенилмочевина для лечения и профилактики болезней и состояний |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL212631A (xx) * | 1949-12-06 | |||
US2867520A (en) * | 1956-11-23 | 1959-01-06 | Monsanto Chemicals | 1-(chloraryl) 3-alkyl 3-alkynyl urea |
US2993930A (en) * | 1958-03-18 | 1961-07-25 | Midwest Research Inst | Tetra-substituted ureas |
US3277061A (en) * | 1963-07-01 | 1966-10-04 | Union Oil Co | Carbonylation of amines and substituted ureas derived therefrom |
US3326663A (en) * | 1964-09-25 | 1967-06-20 | Shell Oil Co | Herbicidal phenylureas |
GB1143802A (xx) * | 1965-03-25 | |||
US3897493A (en) * | 1971-09-13 | 1975-07-29 | Stauffer Chemical Co | Meta-anilide urea compositions and their utility as herbicides |
JPS5224104B2 (xx) * | 1974-10-07 | 1977-06-29 | ||
JPS5312844A (en) * | 1976-07-20 | 1978-02-04 | Nippon Tokushu Noyaku Seizo Kk | Nn44halogenobenzyllnnmethyl*or nonsubstitutedd*cycloalkylln**phenylurea or thiourea compounds* their preparation and fungicides containing the same as active constituents |
DE3027253C2 (de) * | 1980-07-18 | 1982-11-04 | Degussa Ag, 6000 Frankfurt | Verfahren zur Herstellung von Wasserstoffperoxid |
JPS6032447A (ja) * | 1983-08-03 | 1985-02-19 | Nec Corp | 群別2線式搬送回線の折返し回路 |
-
1982
- 1982-01-26 US US06/342,693 patent/US4473579A/en not_active Expired - Fee Related
- 1982-12-01 CA CA000416765A patent/CA1291990C/en not_active Expired - Fee Related
-
1983
- 1983-01-21 PH PH28412A patent/PH18706A/en unknown
- 1983-01-25 JP JP58009484A patent/JPS58134070A/ja active Granted
- 1983-01-25 ZA ZA83484A patent/ZA83484B/xx unknown
- 1983-01-26 BE BE0/209971A patent/BE895708A/fr not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PH18706A (en) | 1985-09-05 |
CA1291990C (en) | 1991-11-12 |
JPS58134070A (ja) | 1983-08-10 |
US4473579A (en) | 1984-09-25 |
JPH0254821B2 (xx) | 1990-11-22 |
BE895708A (fr) | 1983-07-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA83484B (en) | Antiatherosclerotic substituted ureas and thioureas | |
AU537096B2 (en) | N-phenyl-n-benzoyl ureas and thioureas | |
DE3372859D1 (en) | 2,5-dihalogenbenzoyl ureas and thioureas, processes for their preparation and their use as pesticides | |
DE3373901D1 (en) | Sulfonyl ureas | |
IL63094A0 (en) | Substituted ureas and thioureas | |
PH24216A (en) | Antihyperlipidemic and antiatherosclerotic urea and carbamate compounds | |
DE3365991D1 (en) | 2,4-dihalogenbenzoyl ureas and thioureas, processes for their preparation and their use as pesticides | |
GB2113684B (en) | Antiatherosclerotic substituted ureas and thioureas | |
GB2058072B (en) | N-benzoyl-n'-pyridyloxy phenyl ureas and thioureas | |
GB8417126D0 (en) | Antiatherosclerotic ureas and thioureas | |
EP0103537A3 (en) | N-arylsulfonyl-n'-triazolyl urea | |
GB8305735D0 (en) | Ergolinyl ureas | |
DE3374559D1 (en) | Pesticidal 1-(alkyl-phenoxyaryl)-3-benzoyl ureas and process for preparation | |
PH15979A (en) | Isoureas and isothioureas | |
ZA837309B (en) | Herbicidal ureas and process for preparation | |
DE3469343D1 (en) | Antiatherosclerotic agent | |
AU544977B2 (en) | Ureas and thioureas for cardiac arrhythma | |
GB8415124D0 (en) | (3-aryl-5-isothiazolyl)ureas | |
AU544976B2 (en) | Ureas or thioureas substituted by amino and sulfur groups | |
AU547406B2 (en) | 5-t-butyl-3-pyrazolyl carbomates and ureas | |
ZA807458B (en) | Agricutural ureas and isoureas | |
MW2783A1 (en) | Novel pesticidal 1-(alkylphenoxyaryl)-3-benzoyl ureas and process for preparation | |
JPS5791919A (en) | Antiatherosclerotic and compound | |
MX9202872A (es) | Ureas y tioureas antiateroscleroticas. | |
IE791319L (en) | Isoureas and isothioureas |