JPH0244832B2 - - Google Patents

Info

Publication number
JPH0244832B2
JPH0244832B2 JP63016772A JP1677288A JPH0244832B2 JP H0244832 B2 JPH0244832 B2 JP H0244832B2 JP 63016772 A JP63016772 A JP 63016772A JP 1677288 A JP1677288 A JP 1677288A JP H0244832 B2 JPH0244832 B2 JP H0244832B2
Authority
JP
Japan
Prior art keywords
salt
sorbinil
sorbinyl
fluoro
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP63016772A
Other languages
English (en)
Japanese (ja)
Other versions
JPS63211281A (ja
Inventor
Berkeley Wendell Cue Jr
Philip Dietrich Hammenn
Stephen Sargent Massett
Bernard Shields Moore
Robert John Sysko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PFIZER
Original Assignee
PFIZER
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFIZER filed Critical PFIZER
Publication of JPS63211281A publication Critical patent/JPS63211281A/ja
Publication of JPH0244832B2 publication Critical patent/JPH0244832B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
  • Control Of Turbines (AREA)
  • Engine Equipment That Uses Special Cycles (AREA)
JP63016772A 1982-11-10 1988-01-27 ソルビニルのキニン塩およびその製法 Granted JPS63211281A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US440686 1982-11-10
US440641 1982-11-10
US06/440,641 US4435578A (en) 1982-11-10 1982-11-10 Sorbinil by optical resolution of precursor 6-fluoro-4-ureidochroman-4-carboxylic acid
US440657 1982-11-10

Publications (2)

Publication Number Publication Date
JPS63211281A JPS63211281A (ja) 1988-09-02
JPH0244832B2 true JPH0244832B2 (ref) 1990-10-05

Family

ID=23749580

Family Applications (4)

Application Number Title Priority Date Filing Date
JP58211674A Granted JPS59101491A (ja) 1982-11-10 1983-11-10 ソルビニルの（―）―３―アミノメチルピナン塩およびその製法
JP63016772A Granted JPS63211281A (ja) 1982-11-10 1988-01-27 ソルビニルのキニン塩およびその製法
JP63016774A Granted JPS63211282A (ja) 1982-11-10 1988-01-27 ソルビニルの製造工程における、６−フルオル−４−クロマノンを再生する方法
JP63016773A Granted JPS63211278A (ja) 1982-11-10 1988-01-27 Ｓ−６−フルオル−４−ウレイドクロマン−４−カルボン酸のアミン塩およびその製法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP58211674A Granted JPS59101491A (ja) 1982-11-10 1983-11-10 ソルビニルの（―）―３―アミノメチルピナン塩およびその製法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP63016774A Granted JPS63211282A (ja) 1982-11-10 1988-01-27 ソルビニルの製造工程における、６−フルオル−４−クロマノンを再生する方法
JP63016773A Granted JPS63211278A (ja) 1982-11-10 1988-01-27 Ｓ−６−フルオル−４−ウレイドクロマン−４−カルボン酸のアミン塩およびその製法

Country Status (14)

Country Link
US (1) US4435578A (ref)
EP (1) EP0109232B1 (ref)
JP (4) JPS59101491A (ref)
AT (1) ATE23044T1 (ref)
BG (1) BG45388A3 (ref)
CA (1) CA1202034A (ref)
DE (1) DE3367099D1 (ref)
GT (1) GT198303963A (ref)
HU (1) HU191708B (ref)
IE (1) IE56256B1 (ref)
PH (1) PH18843A (ref)
PL (1) PL143960B1 (ref)
SU (1) SU1282816A3 (ref)
ZA (1) ZA838336B (ref)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3565105D1 (en) * 1984-08-20 1988-10-27 Pfizer Process for the production as asymmetric hydantoins
US4620019A (en) * 1984-08-23 1986-10-28 Pfizer Inc. S-6-fluoro-4-aminochroman-4-carboxylic acid derivatives useful as intermediates for sorbinil
US4551542A (en) * 1984-09-26 1985-11-05 Pfizer Inc. Regeneration of 6-fluoro-4-chromanone from 6-fluoro-4-ureidochroman-4-carboxylic acid
FI870445A7 (fi) 1985-06-14 1987-02-02 Pfizer Välituote asymmetrisen hydantoiinin valmistuksessa.
US4841079A (en) * 1987-08-07 1989-06-20 Pfizer, Inc. Process for the production of asymmetric hydantoins
US5206367A (en) * 1992-02-18 1993-04-27 Pfizer Inc. Preparation of optically active spiro-hydantoins

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117230A (en) 1976-10-18 1978-09-26 Pfizer Inc. Hydantoin derivatives as therapeutic agents
US4130714A (en) 1977-05-23 1978-12-19 Pfizer Inc. Hydantoin therapeutic agents
US4348526A (en) 1980-03-28 1982-09-07 Pfizer Inc. Intermediates in the preparation of chiral hydantoins
US4286098A (en) 1980-03-28 1981-08-25 Pfizer Inc. Process for the preparation of chiral hydantoins

Also Published As

Publication number Publication date
DE3367099D1 (en) 1986-11-27
SU1282816A3 (ru) 1987-01-07
IE832619L (en) 1984-05-10
JPH032866B2 (ref) 1991-01-17
JPS63211278A (ja) 1988-09-02
HUT36124A (en) 1985-08-28
GT198303963A (es) 1985-04-30
JPS63211282A (ja) 1988-09-02
JPS63211281A (ja) 1988-09-02
ZA838336B (en) 1985-06-26
JPH0248555B2 (ref) 1990-10-25
ATE23044T1 (de) 1986-11-15
PH18843A (en) 1985-10-10
PL143960B1 (en) 1988-03-31
EP0109232B1 (en) 1986-10-22
US4435578A (en) 1984-03-06
JPS59101491A (ja) 1984-06-12
EP0109232A1 (en) 1984-05-23
CA1202034A (en) 1986-03-18
BG45388A3 (bg) 1989-05-15
HU191708B (en) 1987-03-30
PL250369A1 (en) 1985-09-24
IE56256B1 (en) 1991-06-05
JPS6344755B2 (ref) 1988-09-06

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