JPH0216315B2 - - Google Patents

Info

Publication number
JPH0216315B2
JPH0216315B2 JP56216205A JP21620581A JPH0216315B2 JP H0216315 B2 JPH0216315 B2 JP H0216315B2 JP 56216205 A JP56216205 A JP 56216205A JP 21620581 A JP21620581 A JP 21620581A JP H0216315 B2 JPH0216315 B2 JP H0216315B2
Authority
JP
Japan
Prior art keywords
compound
group
formula
general formula
lower alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP56216205A
Other languages
English (en)
Japanese (ja)
Other versions
JPS57131791A (en
Inventor
Takao Takatani
Zenzaburo Totsuka
Masayoshi Murata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of JPS57131791A publication Critical patent/JPS57131791A/ja
Publication of JPH0216315B2 publication Critical patent/JPH0216315B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP56216205A 1980-12-31 1981-12-28 Benzodiazepine derivative and its preparation Granted JPS57131791A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8041626 1980-12-31

Publications (2)

Publication Number Publication Date
JPS57131791A JPS57131791A (en) 1982-08-14
JPH0216315B2 true JPH0216315B2 (enEXAMPLES) 1990-04-16

Family

ID=10518286

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56216205A Granted JPS57131791A (en) 1980-12-31 1981-12-28 Benzodiazepine derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS57131791A (enEXAMPLES)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464467A (en) * 1982-07-26 1984-08-07 Bristol-Myers Company Antitumor antibiotics produced by new streptomyces
DK1193270T3 (da) 1998-08-27 2003-09-15 Spirogen Ltd Pyrrolobenzodiazepiner
GB9818730D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
GB9818732D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collection of compounds
US6909006B1 (en) 1999-08-27 2005-06-21 Spirogen Limited Cyclopropylindole derivatives
GB0226593D0 (en) 2002-11-14 2002-12-24 Consultants Ltd Compounds
GB0321295D0 (en) 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
GB0404577D0 (en) 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
ES2381858T3 (es) 2004-03-01 2012-06-01 Spirogen Limited Derivados de 11-hidroxi-5H-pirrolo[2,1-C][1,4]benzodiazepin-5-ona como intermedios clave para la preparación de pirrolobenzodiazepinas sustituidas en C2
EP1723152B1 (en) 2004-03-09 2015-02-11 Spirogen Sàrl Pyrrolobenzodiazepines
GB0819095D0 (en) 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
MX2011008328A (es) 2009-02-05 2011-11-04 Immunogen Inc Derivados novedosos de benzodiacepina.
AU2015224492B2 (en) * 2009-02-05 2017-04-20 Immunogen, Inc. Novel benzodiazepine derivatives
GB201006340D0 (en) 2010-04-15 2010-06-02 Spirogen Ltd Synthesis method and intermediates
EP2789622B1 (en) 2010-04-15 2017-03-01 MedImmune Limited Pyrrolobenzodiazepines used to treat proliferative diseases
KR101772354B1 (ko) 2010-04-15 2017-08-28 시애틀 지네틱스, 인크. 표적화된 피롤로벤조디아제핀 접합체
IL279304B (en) 2011-02-15 2022-07-01 Immunogen Inc Method for producing an indolinobenzodiazepine
EP2753178B1 (en) 2011-10-14 2017-12-06 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
CN108164551A (zh) 2011-10-14 2018-06-15 西雅图基因公司 吡咯并苯并二氮杂卓和靶向结合物
EP2751076B1 (en) 2011-10-14 2018-04-25 MedImmune Limited Synthesis method and intermediates useful in the preparation of pyrrolobenzodiazepines
CA2887899C (en) 2012-10-12 2020-03-31 Adc Therapeutics Sarl Pyrrolobenzodiazepine-anti-cd22 antibody conjugates
HRP20180945T1 (hr) 2012-10-12 2018-08-10 Adc Therapeutics Sa Konjugati protutijelo-pirolobenzodiazepin
JP6270859B2 (ja) 2012-10-12 2018-01-31 エイディーシー・セラピューティクス・エス・アー・エール・エルＡｄｃ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｓａｒｌ ピロロベンゾジアゼピン−抗体結合体
EP2906298B1 (en) 2012-10-12 2018-10-03 ADC Therapeutics SA Pyrrolobenzodiazepine-antibody conjugates
ME02055B (me) 2012-10-12 2015-05-20 Medimmune Ltd Pirolobenzodiazepini i njihovi konjugati
US10736903B2 (en) 2012-10-12 2020-08-11 Medimmune Limited Pyrrolobenzodiazepine-anti-PSMA antibody conjugates
ES2660029T3 (es) 2012-10-12 2018-03-20 Medimmune Limited Conjugados de anticuerpo-pirrolobenzodiazepinas
US9745303B2 (en) 2012-10-12 2017-08-29 Medimmune Limited Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
EP3054985B1 (en) 2013-10-11 2018-12-26 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
WO2015052532A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
US9956299B2 (en) 2013-10-11 2018-05-01 Medimmune Limited Pyrrolobenzodiazepine—antibody conjugates
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
US10780096B2 (en) 2014-11-25 2020-09-22 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
HRP20210979T1 (hr) 2017-02-08 2021-09-17 Adc Therapeutics Sa Konjugati pirolobenzodiazepin-protutijelo
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
PT3612537T (pt) 2017-04-18 2022-08-29 Medimmune Ltd Conjugados de pirrolobenzodiazepina
BR112019021880A2 (pt) 2017-04-20 2020-06-02 Adc Therapeutics Sa Terapia de combinação com conjugado anticorpo anti-axl-droga
BR112019026564A2 (pt) 2017-06-14 2020-06-30 Adc Therapeutics Sa regimes de dosagem para a administração de um adc anti-cd19
WO2019034764A1 (en) 2017-08-18 2019-02-21 Medimmune Limited CONJUGATES OF PYRROLOBENZODIAZEPINE
KR20200061376A (ko) 2017-09-29 2020-06-02 다이이찌 산쿄 가부시키가이샤 항체-피롤로벤조디아제핀 유도체 콘쥬게이트
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
SG11202108900WA (en) 2019-03-15 2021-09-29 Medimmune Ltd Azetidobenzodiazepine dimers and conjugates comprising them for use in the treatment of cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5752521B2 (enEXAMPLES) * 1972-06-29 1982-11-08
JPS5345703B2 (enEXAMPLES) * 1972-06-29 1978-12-08
JPS5283700A (en) * 1976-01-01 1977-07-12 Microbial Chem Res Found Novel antibiotics neothramycin
JPS604835B2 (ja) * 1976-09-17 1985-02-06 財団法人微生物化学研究会 ネオスラマイシンの製造法

Also Published As

Publication number Publication date
JPS57131791A (en) 1982-08-14

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