JPH0216315B2 - - Google Patents

Info

Publication number
JPH0216315B2
JPH0216315B2 JP56216205A JP21620581A JPH0216315B2 JP H0216315 B2 JPH0216315 B2 JP H0216315B2 JP 56216205 A JP56216205 A JP 56216205A JP 21620581 A JP21620581 A JP 21620581A JP H0216315 B2 JPH0216315 B2 JP H0216315B2
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP56216205A
Other versions
JPS57131791A (en
Inventor
Takao Takatani
Zenzaburo Totsuka
Masayoshi Murata
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB8041626 priority Critical
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of JPS57131791A publication Critical patent/JPS57131791A/en
Publication of JPH0216315B2 publication Critical patent/JPH0216315B2/ja
Anticipated expiration legal-status Critical
Application status is Expired - Lifetime legal-status Critical

Links

JP56216205A 1980-12-31 1981-12-28 Expired - Lifetime JPH0216315B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB8041626 1980-12-31

Publications (2)

Publication Number Publication Date
JPS57131791A JPS57131791A (en) 1982-08-14
JPH0216315B2 true JPH0216315B2 (en) 1990-04-16

Family

ID=10518286

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56216205A Expired - Lifetime JPH0216315B2 (en) 1980-12-31 1981-12-28

Country Status (1)

Country Link
JP (1) JPH0216315B2 (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464467A (en) * 1982-07-26 1984-08-07 Bristol-Myers Company Antitumor antibiotics produced by new streptomyces
AT151760T (en) * 1987-02-23 1997-05-15 Ono Pharmaceutical Co Thiazolidine derivatives
GB9818730D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
JP4824165B2 (en) * 1998-08-27 2011-11-30 スパイロジエン・リミテツド Pyrrolobenzodiazepines
GB9818732D0 (en) * 1998-08-27 1998-10-21 Univ Portsmouth Collection of compounds
US6909006B1 (en) 1999-08-27 2005-06-21 Spirogen Limited Cyclopropylindole derivatives
GB0226593D0 (en) 2002-11-14 2002-12-24 Consultants Ltd Compounds
GB0321295D0 (en) 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
DK1720881T3 (en) 2004-03-01 2013-02-11 Spirogen Sarl 11-Hydroxy-5h- (2,1-c) (1,4) benzodiazepin-5-one derivatives as key intermediates in the preparation of c2-substituted pyrrolobenzodiazepines
GB0404577D0 (en) 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
JP5166861B2 (en) 2004-03-09 2013-03-21 スピロゲン リミティッド Pyrrolobenzodiazepine
GB0819095D0 (en) 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines
EP2393362B1 (en) 2009-02-05 2016-08-24 Immunogen, Inc. Novel benzodiazepine derivatives
AU2015224492B2 (en) * 2009-02-05 2017-04-20 Immunogen, Inc. Novel benzodiazepine derivatives
EP2558475A1 (en) 2010-04-15 2013-02-20 Spirogen Sàrl Pyrrolobenzodiazepines used to treat proliferative diseases
GB201006340D0 (en) 2010-04-15 2010-06-02 Spirogen Ltd Synthesis method and intermediates
US9242013B2 (en) 2010-04-15 2016-01-26 Seattle Genetics Inc. Targeted pyrrolobenzodiazapine conjugates
ES2567418T3 (en) 2011-02-15 2016-04-22 Immunogen Inc Cytotoxic benzodiazepine derivatives
AU2012322933B2 (en) 2011-10-14 2017-02-02 Medimmune Limited Synthesis method and intermediates useful in the preparation of pyrrolobenzodiazepines
JP6393617B2 (en) 2011-10-14 2018-09-19 シアトル ジェネティクス,インコーポレーテッド Pyrrolobenzodiazepine and target conjugates
JP6399930B2 (en) 2011-10-14 2018-10-03 シアトル ジェネティクス,インコーポレーテッド Pyrrolobenzodiazepine and target conjugates
LT2839860T (en) 2012-10-12 2019-07-10 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
PL2906296T3 (en) 2012-10-12 2018-09-28 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
ES2703151T3 (en) 2012-10-12 2019-03-07 Adc Therapeutics Sa Pyrrolobenzodiazepine antibody conjugates
JP6367204B2 (en) 2012-10-12 2018-08-01 メドイミューン・リミテッドMedImmune Limited Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
LT2906251T (en) 2012-10-12 2017-12-11 Adc Therapeutics Sa Pyrrolobenzodiazepine-anti-cd22 antibody conjugates
EP3054986B1 (en) 2013-10-11 2019-03-20 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
EP3054985B1 (en) 2013-10-11 2018-12-26 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
EP3054983B1 (en) 2013-10-11 2019-03-20 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4925956A (en) * 1972-06-29 1974-03-07
JPS4925957A (en) * 1972-06-29 1974-03-07
JPS5283700A (en) * 1976-01-01 1977-07-12 Microbial Chem Res Found Novel antibiotics neothramycin
JPS5337692A (en) * 1976-09-17 1978-04-06 Microbial Chem Res Found Preparation of neosulamycin

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4925956A (en) * 1972-06-29 1974-03-07
JPS4925957A (en) * 1972-06-29 1974-03-07
JPS5283700A (en) * 1976-01-01 1977-07-12 Microbial Chem Res Found Novel antibiotics neothramycin
JPS5337692A (en) * 1976-09-17 1978-04-06 Microbial Chem Res Found Preparation of neosulamycin

Also Published As

Publication number Publication date
JPS57131791A (en) 1982-08-14

Similar Documents

Publication Publication Date Title
CA1261340C (en)
DE3001071C2 (en)
DE3003354C2 (en)
DE3006837C2 (en)
DE3006801C2 (en)
DE3005185C2 (en)
AU82296S (en)
CH656755B (en)
DE3003255C2 (en)
DE3005147C2 (en)
DE3007752C2 (en)
DE3004411C2 (en)
DE3004511C2 (en)
DE3000772C2 (en)
CH655452B (en)
DE3004595C2 (en)
DE3000511C2 (en)
DE3000545C2 (en)
DE3001786C2 (en)
DE3003620C2 (en)
DE3007534C2 (en)
DE3006237C2 (en)
DE3005319C2 (en)
DE3004829C2 (en)
DE3001421C2 (en)