JPH0215541B2 - - Google Patents
Info
- Publication number
- JPH0215541B2 JPH0215541B2 JP55128159A JP12815980A JPH0215541B2 JP H0215541 B2 JPH0215541 B2 JP H0215541B2 JP 55128159 A JP55128159 A JP 55128159A JP 12815980 A JP12815980 A JP 12815980A JP H0215541 B2 JPH0215541 B2 JP H0215541B2
- Authority
- JP
- Japan
- Prior art keywords
- thio
- methyl
- acid
- butyramide
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 125000000217 alkyl group Chemical group 0.000 claims description 10
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 6
- 229910052717 sulfur Inorganic materials 0.000 claims description 6
- 125000004434 sulfur atom Chemical group 0.000 claims description 6
- 125000003277 amino group Chemical group 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- 125000003545 alkoxy group Chemical group 0.000 claims description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 4
- 125000002947 alkylene group Chemical group 0.000 claims description 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 3
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 2
- -1 methylene, ethylene, trimethylene, tetramethylene, pentamethylene, hexamethylene, methylmethylene, 2-methyltrimethylene, 2,2-dimethyltrimethylene Chemical group 0.000 description 60
- 238000006243 chemical reaction Methods 0.000 description 39
- 150000001875 compounds Chemical class 0.000 description 37
- 238000000034 method Methods 0.000 description 28
- 150000001412 amines Chemical class 0.000 description 25
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 24
- 239000002904 solvent Substances 0.000 description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 22
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 20
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 15
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 15
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 15
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 15
- 235000019441 ethanol Nutrition 0.000 description 15
- 239000000243 solution Substances 0.000 description 15
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 12
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 239000003795 chemical substances by application Substances 0.000 description 12
- 239000003826 tablet Substances 0.000 description 12
- 239000000203 mixture Substances 0.000 description 10
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 9
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 9
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 9
- 150000007514 bases Chemical class 0.000 description 9
- 229920001223 polyethylene glycol Polymers 0.000 description 9
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 8
- 150000008065 acid anhydrides Chemical class 0.000 description 8
- 238000000921 elemental analysis Methods 0.000 description 8
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 7
- 229920002472 Starch Polymers 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 7
- 239000003699 antiulcer agent Substances 0.000 description 7
- 150000002148 esters Chemical class 0.000 description 7
- 239000000843 powder Substances 0.000 description 7
- 239000008107 starch Substances 0.000 description 7
- 235000019698 starch Nutrition 0.000 description 7
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 7
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 6
- SJRJJKPEHAURKC-UHFFFAOYSA-N N-Methylmorpholine Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 6
- 239000002202 Polyethylene glycol Substances 0.000 description 6
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 238000005886 esterification reaction Methods 0.000 description 6
- 239000007924 injection Substances 0.000 description 6
- 238000002347 injection Methods 0.000 description 6
- 239000008101 lactose Substances 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 238000002844 melting Methods 0.000 description 6
- 230000008018 melting Effects 0.000 description 6
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 6
- 230000035484 reaction time Effects 0.000 description 6
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 5
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 5
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 5
- 150000001244 carboxylic acid anhydrides Chemical class 0.000 description 5
- 239000003054 catalyst Substances 0.000 description 5
- 150000002170 ethers Chemical class 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 239000008103 glucose Substances 0.000 description 5
- 230000002140 halogenating effect Effects 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 239000008096 xylene Substances 0.000 description 5
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 4
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 229920002261 Corn starch Polymers 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
- WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 description 4
- 150000001298 alcohols Chemical class 0.000 description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 4
- 239000008120 corn starch Substances 0.000 description 4
- 229940099112 cornstarch Drugs 0.000 description 4
- 239000013078 crystal Substances 0.000 description 4
- 150000008282 halocarbons Chemical class 0.000 description 4
- 235000019359 magnesium stearate Nutrition 0.000 description 4
- 239000002798 polar solvent Substances 0.000 description 4
- 235000011121 sodium hydroxide Nutrition 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 4
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical class CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 3
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
- 239000005995 Aluminium silicate Substances 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 3
- JLTDJTHDQAWBAV-UHFFFAOYSA-N N,N-dimethylaniline Chemical compound CN(C)C1=CC=CC=C1 JLTDJTHDQAWBAV-UHFFFAOYSA-N 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 238000003436 Schotten-Baumann reaction Methods 0.000 description 3
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 description 3
- 230000002411 adverse Effects 0.000 description 3
- 235000012211 aluminium silicate Nutrition 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 238000006664 bond formation reaction Methods 0.000 description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- 239000000969 carrier Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 238000004440 column chromatography Methods 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 239000012024 dehydrating agentsâ Substances 0.000 description 3
- 239000007884 disintegrant Substances 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- OAYLNYINCPYISS-UHFFFAOYSA-N ethyl acetate;hexane Chemical compound CCCCCC.CCOC(C)=O OAYLNYINCPYISS-UHFFFAOYSA-N 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- GNOIPBMMFNIUFM-UHFFFAOYSA-N hexamethylphosphoric triamide Chemical compound CN(C)P(=O)(N(C)C)N(C)C GNOIPBMMFNIUFM-UHFFFAOYSA-N 0.000 description 3
- 238000006460 hydrolysis reaction Methods 0.000 description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 239000006187 pill Substances 0.000 description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
- 229910000027 potassium carbonate Inorganic materials 0.000 description 3
- 235000011181 potassium carbonates Nutrition 0.000 description 3
- 235000011118 potassium hydroxide Nutrition 0.000 description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 3
- 239000000829 suppository Substances 0.000 description 3
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 description 2
- YOETUEMZNOLGDB-UHFFFAOYSA-N 2-methylpropyl carbonochloridate Chemical compound CC(C)COC(Cl)=O YOETUEMZNOLGDB-UHFFFAOYSA-N 0.000 description 2
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 description 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 229920001543 Laminarin Polymers 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 2
- 229920001214 Polysorbate 60 Polymers 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 235000010419 agar Nutrition 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N beta-monoglyceryl stearate Natural products CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- WTEOIRVLGSZEPR-UHFFFAOYSA-N boron trifluoride Chemical compound FB(F)F WTEOIRVLGSZEPR-UHFFFAOYSA-N 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 229940110456 cocoa butter Drugs 0.000 description 2
- 235000019868 cocoa butter Nutrition 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 description 2
- ZKQFHRVKCYFVCN-UHFFFAOYSA-N ethoxyethane;hexane Chemical compound CCOCC.CCCCCC ZKQFHRVKCYFVCN-UHFFFAOYSA-N 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000007941 film coated tablet Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
- 239000012442 inert solvent Substances 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 150000007529 inorganic bases Chemical class 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- DBTMGCOVALSLOR-VPNXCSTESA-N laminarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1O[C@@H]1[C@@H](O)C(O[C@H]2[C@@H]([C@@H](CO)OC(O)[C@@H]2O)O)O[C@H](CO)[C@H]1O DBTMGCOVALSLOR-VPNXCSTESA-N 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 150000007522 mineralic acids Chemical class 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 229910017604 nitric acid Inorganic materials 0.000 description 2
- WRSAYLZFQLMHKQ-UHFFFAOYSA-N o-methyl butanethioate Chemical compound CCCC(=S)OC WRSAYLZFQLMHKQ-UHFFFAOYSA-N 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 235000005985 organic acids Nutrition 0.000 description 2
- 150000007530 organic bases Chemical class 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 description 2
- 229940093429 polyethylene glycol 6000 Drugs 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 239000011736 potassium bicarbonate Substances 0.000 description 2
- 235000015497 potassium bicarbonate Nutrition 0.000 description 2
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 2
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 2
- 229940086066 potassium hydrogencarbonate Drugs 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 2
- 235000012239 silicon dioxide Nutrition 0.000 description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 description 2
- 235000017550 sodium carbonate Nutrition 0.000 description 2
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 2
- 229940001584 sodium metabisulfite Drugs 0.000 description 2
- 235000010262 sodium metabisulphite Nutrition 0.000 description 2
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical class O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- 235000012222 talc Nutrition 0.000 description 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 2
- IMNIMPAHZVJRPE-UHFFFAOYSA-N triethylenediamine Chemical compound C1CN2CCN1CC2 IMNIMPAHZVJRPE-UHFFFAOYSA-N 0.000 description 2
- WJKHJLXJJJATHN-UHFFFAOYSA-N triflic anhydride Chemical compound FC(F)(F)S(=O)(=O)OS(=O)(=O)C(F)(F)F WJKHJLXJJJATHN-UHFFFAOYSA-N 0.000 description 2
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 2
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
- 239000002966 varnish Substances 0.000 description 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- ZXSQEZNORDWBGZ-UHFFFAOYSA-N 1,3-dihydropyrrolo[2,3-b]pyridin-2-one Chemical compound C1=CN=C2NC(=O)CC2=C1 ZXSQEZNORDWBGZ-UHFFFAOYSA-N 0.000 description 1
- OGFAWKRXZLGJSK-UHFFFAOYSA-N 1-(2,4-dihydroxyphenyl)-2-(4-nitrophenyl)ethanone Chemical compound OC1=CC(O)=CC=C1C(=O)CC1=CC=C([N+]([O-])=O)C=C1 OGFAWKRXZLGJSK-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- HEWZVZIVELJPQZ-UHFFFAOYSA-N 2,2-dimethoxypropane Chemical compound COC(C)(C)OC HEWZVZIVELJPQZ-UHFFFAOYSA-N 0.000 description 1
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 1
- JVKRKMWZYMKVTQ-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]pyrazol-1-yl]-N-(2-oxo-3H-1,3-benzoxazol-6-yl)acetamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C=1C=NN(C=1)CC(=O)NC1=CC2=C(NC(O2)=O)C=C1 JVKRKMWZYMKVTQ-UHFFFAOYSA-N 0.000 description 1
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
- VKCLBNXEILMXBP-UHFFFAOYSA-N 4-chloro-n-cyclohexyl-n-ethylbutanamide Chemical compound ClCCCC(=O)N(CC)C1CCCCC1 VKCLBNXEILMXBP-UHFFFAOYSA-N 0.000 description 1
- ZVGKPQCCKGLQPB-UHFFFAOYSA-N 5-methyl-3h-1,3,4-oxadiazole-2-thione Chemical compound CC1=NN=C(S)O1 ZVGKPQCCKGLQPB-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 229910015900 BF3 Inorganic materials 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 description 1
- 239000004606 Fillers/Extenders Substances 0.000 description 1
- DCXXMTOCNZCJGO-UHFFFAOYSA-N Glycerol trioctadecanoate Natural products CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 1
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 229920001800 Shellac Polymers 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 244000299461 Theobroma cacao Species 0.000 description 1
- 235000005764 Theobroma cacao ssp. cacao Nutrition 0.000 description 1
- 235000005767 Theobroma cacao ssp. sphaerocarpum Nutrition 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- GHVZOJONCUEWAV-UHFFFAOYSA-N [K].CCO Chemical compound [K].CCO GHVZOJONCUEWAV-UHFFFAOYSA-N 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 229940095564 anhydrous calcium sulfate Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000767 anti-ulcer Effects 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 description 1
- 229940092714 benzenesulfonic acid Drugs 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 235000014121 butter Nutrition 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000001046 cacaotero Nutrition 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 150000001718 carbodiimides Chemical class 0.000 description 1
- PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000003729 cation exchange resin Substances 0.000 description 1
- 229940023913 cation exchange resins Drugs 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 229940125904 compound 1 Drugs 0.000 description 1
- 238000006482 condensation reaction Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229910000365 copper sulfate Inorganic materials 0.000 description 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000000640 cyclooctyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
- 239000002274 desiccant Substances 0.000 description 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
- SBZXBUIDTXKZTM-UHFFFAOYSA-N diglyme Chemical compound COCCOCCOC SBZXBUIDTXKZTM-UHFFFAOYSA-N 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- YWEUIGNSBFLMFL-UHFFFAOYSA-N diphosphonate Chemical compound O=P(=O)OP(=O)=O YWEUIGNSBFLMFL-UHFFFAOYSA-N 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 239000002662 enteric coated tablet Substances 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- XCPXPFNKTCFWTA-UHFFFAOYSA-N ethyl carbonobromidate Chemical compound CCOC(Br)=O XCPXPFNKTCFWTA-UHFFFAOYSA-N 0.000 description 1
- RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000003707 hexyloxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O* 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000000644 isotonic solution Substances 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 244000145841 kine Species 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910000000 metal hydroxide Inorganic materials 0.000 description 1
- 150000004692 metal hydroxides Chemical class 0.000 description 1
- 229910001511 metal iodide Inorganic materials 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- QQHNGZNHRRLNKI-UHFFFAOYSA-N methyl carbonobromidate Chemical compound COC(Br)=O QQHNGZNHRRLNKI-UHFFFAOYSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- XMJHPCRAQCTCFT-UHFFFAOYSA-N methyl chloroformate Chemical compound COC(Cl)=O XMJHPCRAQCTCFT-UHFFFAOYSA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- AGVKXDPPPSLISR-UHFFFAOYSA-N n-ethylcyclohexanamine Chemical compound CCNC1CCCCC1 AGVKXDPPPSLISR-UHFFFAOYSA-N 0.000 description 1
- PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- NMHMNPHRMNGLLB-UHFFFAOYSA-N phloretic acid Chemical compound OC(=O)CCC1=CC=C(O)C=C1 NMHMNPHRMNGLLB-UHFFFAOYSA-N 0.000 description 1
- UXCDUFKZSUBXGM-UHFFFAOYSA-N phosphoric tribromide Chemical compound BrP(Br)(Br)=O UXCDUFKZSUBXGM-UHFFFAOYSA-N 0.000 description 1
- UHZYTMXLRWXGPK-UHFFFAOYSA-N phosphorus pentachloride Chemical compound ClP(Cl)(Cl)(Cl)Cl UHZYTMXLRWXGPK-UHFFFAOYSA-N 0.000 description 1
- DLYUQMMRRRQYAE-UHFFFAOYSA-N phosphorus pentoxide Inorganic materials O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 229920001993 poloxamer 188 Polymers 0.000 description 1
- 229920000137 polyphosphoric acid Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229960003975 potassium Drugs 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 235000007686 potassium Nutrition 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 210000001187 pylorus Anatomy 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- LKZMBDSASOBTPN-UHFFFAOYSA-L silver carbonate Substances [Ag].[O-]C([O-])=O LKZMBDSASOBTPN-UHFFFAOYSA-L 0.000 description 1
- 229910001958 silver carbonate Inorganic materials 0.000 description 1
- 235000020374 simple syrup Nutrition 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
- 235000009518 sodium iodide Nutrition 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 238000009495 sugar coating Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Landscapes
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
æ¬çºæã¯æ°èŠãªã¢ã«ã«ã³é
žèªå°äœããã³ãã®å¡©
ã«é¢ãããæ¬çºæã®ã¢ã«ã«ã³é žèªå°äœã¯æ°èŠåå
ç©ã§ãããäžè¬åŒ ãåŒäžãR1ã¯æ°ŽçŽ ååãäœçŽã¢ã«ãã«åºãŸã
ã¯ã¢ããåºãR2ã¯æ°Žé žåºãäœçŽã¢ã«ã³ãã·åºãŸ
ãã¯åº
ã«é¢ãããæ¬çºæã®ã¢ã«ã«ã³é žèªå°äœã¯æ°èŠåå
ç©ã§ãããäžè¬åŒ ãåŒäžãR1ã¯æ°ŽçŽ ååãäœçŽã¢ã«ãã«åºãŸã
ã¯ã¢ããåºãR2ã¯æ°Žé žåºãäœçŽã¢ã«ã³ãã·åºãŸ
ãã¯åº
ãåŒãã瀺ããR3ããã³R4ã¯åã
æ°ŽçŽ ååãäœçŽã¢ã«ãã«åºãŸãã¯ã·ã¯ãã¢ã«ãã«
åºãã¯äœçŽã¢ã«ãã¬ã³åºã瀺ãããŸããã¯é ž
çŽ ååãç¡«é»ååãŸãã¯ïŒ®âR5ã瀺ããR5ã¯
æ°ŽçŽ ååãŸãã¯äœçŽã¢ã«ãã«åºã瀺ãããã ãã
R1ãæ°ŽçŽ åå瀺ããšãã¯NHã瀺ããR1ã
äœçŽã¢ã«ãã«åºã瀺ããšãã¯ç¡«é»ååã§ãã€ãŠ
ã¯ãªãããR1ãã¢ããåºã瀺ããšãã¯ç¡«é»å
åã瀺ããã ã§è¡šããããã æ¬çºæã®ååç©ã¯ãæ朰çäœçšããã³æ¶çäœçš
ãæããæ朰çå€ããã³æ¶çå€ãšããŠæçšã§ã
ãã æ¬æ现æžã«ãããŠäœçŽã¢ã«ãã«åºãšããŠã¯ãäŸ
ãã°ã¡ãã«ããšãã«ããããã«ãã€ãœãããã«ã
ããã«ãtertâããã«ããã³ãã«ãããã·ã«åºãª
ã©ãäŸç€ºã§ãããã·ã¯ãã¢ã«ãã«åºãšããŠã¯ãäŸ
ãã°ãã·ã¯ããããã«ãã·ã¯ãããã«ãã·ã¯ãã
ã³ãã«ãã·ã¯ãããã·ã«ãã·ã¯ããããã«ãã·ã¯
ããªã¯ãã«ãªã©ãäŸç€ºã§ãããäœçŽã¢ã«ãã¬ã³åº
ãšããŠã¯ãäŸãã°ãã¡ãã¬ã³ããšãã¬ã³ãããªã¡
ãã¬ã³ãããã©ã¡ãã¬ã³ããã³ã¿ã¡ãã¬ã³ããã
ãµã¡ãã¬ã³ãã¡ãã«ã¡ãã¬ã³ïŒâã¡ãã«ããªã¡ã
ã¬ã³ãïŒïŒïŒâãžã¡ãã«ããªã¡ãã¬ã³ãïŒâã¡ã
ã«ããªã¡ãã¬ã³åºãªã©ãæããããäœçŽã¢ã«ã³ã
ã·åºãšããŠã¯ãäŸãã°ãã¡ããã·ããšããã·ãã
ãããã·ãã€ãœããããã·ããããã·ãtertâã
ããã·ããã³ãã«ãªãã·ãããã·ã«ãªãã·åºãªã©
ãäŸç€ºã§ããã æ¬çºæã®ä»£è¡šçãªååç©ãšããŠã¯ãäŸãã°äžèš
ã®ãã®ãæããããã âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâããã«ã¢ããã âã¡ãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâããã«ã¢ãã âã·ã¯ãããã·ã«âïŒâïŒïŒâã¡ãã«âïŒïŒ
ïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâã
ãã«ã¢ãã âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ãšãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâããã«ã¢ãã âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâããããªã³ã¢ãã âã¡ãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâã¢ã»ãã¢ãã âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâãã¬ã«ã¢ãã âã¡ãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâããã¿ã³ã¢ãã âã¡ãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâïŒâã¡ãã«ããã«ã¢ãã âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ããã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâããããªã³ã¢ãã ïŒïŒ®âãžã·ã¯ãããã·ã«âïŒâïŒïŒâã¡ãã«
âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€ã«ïŒã
ãªâããã«ã¢ãã âã·ã¯ãããã·ã«ââã·ã¯ããªã¯ãã«âïŒ
âïŒïŒâã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«
âïŒâã€ã«ïŒããªâããã«ã¢ãã ïŒïŒ®âãžã¡ãã«âïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒ
ïŒâãªããµãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâããã«
ã¢ãã ïŒïŒ®âãžãšãã«âïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒ
ïŒâãªããµãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâããã«
ã¢ãã ïŒïŒ®âãžã€ãœãããã«âïŒâïŒïŒâã¡ãã«â
ïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€ã«ïŒããª
âããã«ã¢ãã ïŒïŒ®âãžããã·ã«âïŒâïŒïŒâã¡ãã«âïŒïŒ
ïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâã
ãã«ã¢ãã âã¡ãã«ââãšãã«âïŒâïŒïŒâã¡ãã«â
ïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€ã«ïŒããª
âããã«ã¢ãã ïŒïŒ®âãžãšãã«âïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒ
ïŒâãªããµãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâãã¬ã«
ã¢ãã ïŒïŒ®âãžãšãã«âïŒâïŒïŒâã€ãœãããã«â
ïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€ã«ïŒããª
âããã«ã¢ãã ïŒïŒ®âãžã¡ãã«âïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒ
ïŒâãªããµãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâïŒâã¡
ãã«ããã«ã¢ãã ïŒïŒ®âãžãšãã«âïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒ
ïŒâãªããµãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâããã
ãªã³ã¢ãã âãšãã«âïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒïŒâ
ãªããµãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâããã«ã¢ã
ã ïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸ
ãŒã«âïŒâã€ã«ïŒããªâããã«ã¢ãã ïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸ
ãŒã«âïŒâã€ã«ïŒããªâé ªé žã¡ãã«ãšã¹ãã« ïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸ
ãŒã«âïŒâã€ã«ïŒããªâããããªã³é žã€ãœããã
ã«ãšã¹ãã« ïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸ
ãŒã«âïŒâã€ã«ïŒããªâåèé žã¡ãã«ãšã¹ãã« ïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸ
ãŒã«âïŒâã€ã«ïŒããªâé ªé ž ïŒâïŒïŒâãšãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸ
ãŒã«âïŒâã€ã«ïŒããªâé ªé ž ïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸ
ãŒã«âïŒâã€ã«ïŒããªâåèé ž âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâããã«ã¢ãã âããã«ââã·ã¯ããªã¯ãã«âïŒâïŒïŒâ
ã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâããã«ã¢ãã âã¡ãã«ââã·ã¯ããã³ãã«âïŒâïŒïŒâ
ã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâããã«ã¢ãã âã¡ãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâããã«ã¢ãã âã·ã¯ãããã·ã«âïŒâïŒïŒâã¢ããâïŒïŒ
ïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâãã
ã«ã¢ãã âã¡ãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâããããªã³ã¢ãã âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâã¢ã»ãã¢ãã âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâã¡ãã«ããã«ã¢ãã âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâããããªã³ã¢ãã ïŒïŒ®âãžã·ã¯ãããã·ã«âïŒâïŒïŒâã¢ãã
âïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒããª
âããã«ã¢ãã ïŒïŒ®âãžã¡ãã«âïŒâïŒïŒâã¢ããâïŒïŒïŒïŒ
ïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâããã«ã¢
ãã ïŒïŒ®âãžãšãã«âïŒâïŒïŒâã¢ããâïŒïŒïŒïŒ
ïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâããã«ã¢
ãã ïŒïŒ®âãžããã·ã«âïŒâïŒïŒâã¢ããâïŒïŒ
ïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâãã
ã«ã¢ãã âã¡ãã«ââãšãã«âïŒâïŒïŒâã¢ããâ
ïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâ
ããã«ã¢ãã ïŒïŒ®âãžãšãã«âïŒâïŒïŒâã¢ããâïŒïŒïŒïŒ
ïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâãã¬ã«ã¢
ãã ïŒïŒ®âãžã¡ãã«âïŒâïŒïŒâã¢ããâïŒïŒïŒïŒ
ïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâïŒâã¡ã
ã«ããã«ã¢ãã ïŒïŒ®âãžãšãã«âïŒâïŒïŒâã¢ããâïŒïŒïŒïŒ
ïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâããããª
ã³ã¢ãã âãšãã«âïŒâïŒïŒâã¢ããâïŒïŒïŒïŒïŒâ
ãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâããã«ã¢ãã ïŒâïŒïŒâã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒ
ã«âïŒâã€ã«ïŒããªâããã«ã¢ãã ïŒâïŒïŒâã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒ
ã«âïŒâã€ã«ïŒããªâé ªé žã¡ãã«ãšã¹ãã« ïŒâïŒïŒâã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒ
ã«âïŒâã€ã«ïŒããªâããããªã³é žã€ãœãããã«
ãšã¹ãã« ïŒâïŒïŒâã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒ
ã«âïŒâã€ã«ïŒããªâé ªé žãšãã«ãšã¹ãã« ïŒâïŒïŒâã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒ
ã«âïŒâã€ã«ïŒããªâåèé žã¡ãã«ãšã¹ãã« ïŒâïŒïŒâã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒ
ã«âïŒâã€ã«ïŒããªâé ªé ž ïŒâïŒïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒ
ããªâé ªé ž âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒïŒ
ïŒâãžã¡ãã«âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâ
ã€ã«ïŒããªâããã«ã¢ãã âããã«ââã·ã¯ããªã¯ãã«âïŒâïŒïŒïŒ
ïŒâãžã¡ãã«âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâ
ã€ã«ïŒããªâããã«ã¢ãã âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ã¡ãã«âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€ã«ïŒ
ããªâããã«ã¢ãã âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒ4Hâ
ïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€ã«ïŒâããã«
ã¢ãã âã¡ãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒïŒ
ïŒâãžãšãã«âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâ
ã€ã«ïŒããªâããã«ã¢ãã âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
tertâããã«âïŒâã¡ãã«âïŒïŒïŒïŒïŒâããªã¢
ãŸãŒã«âïŒâã€ã«ïŒããªâããã«ã¢ãã âã·ã¯ãããã·ã«âïŒâïŒïŒïŒïŒâãžã¡ãã«
âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€ã«ïŒããªâ
ããã«ã¢ãã âã¡ãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒïŒ
ïŒâãžã¡ãã«âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâ
ã€ã«ïŒããªâããããªã³ã¢ãã âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒïŒ
ïŒâãžã¡ãã«âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâ
ã€ã«ïŒããªâã¢ã»ãã¢ãã âã¡ãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒïŒ
ïŒâãžã¡ãã«âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâ
ã€ã«ïŒããªâãã¬ã«ã¢ãã âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒïŒ
ïŒâãžã¡ãã«âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâ
ã€ã«ïŒããªâïŒâã¡ãã«ããã«ã¢ãã ïŒïŒ®âãžã·ã¯ãããã·ã«âïŒâïŒïŒïŒïŒâãž
ã¡ãã«âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€ã«ïŒ
ããªâããã«ã¢ãã ïŒïŒ®âãžã¡ãã«âïŒâïŒïŒïŒïŒâãžã¡ãã«â
ïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€ã«ïŒããªâã
ãã«ã¢ãã ïŒïŒ®âãžãšãã«âïŒâïŒïŒïŒïŒâãžã¡ãã«â
ïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€ã«ïŒããªâã
ãã«ã¢ãã ïŒïŒ®âãžããã·ã«âïŒâïŒïŒïŒïŒâãžã¡ãã«
âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€ã«ïŒããªâ
ããã«ã¢ãã âã¡ãã«ââãšãã«âïŒâïŒïŒïŒïŒâãžã¡
ãã«âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€ã«ïŒã
ãªâããã«ã¢ãã ïŒïŒ®âãžãšãã«âïŒâïŒïŒïŒïŒâãžãšãã«â
ïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€ã«ïŒããªâã
ãã«ã¢ãã ïŒïŒ®âãžã¡ãã«âïŒâïŒ4HâïŒïŒïŒïŒïŒâã
ãªã¢ãŸãŒã«âïŒâã€ã«ïŒããªâããã«ã¢ãã ïŒïŒ®âãžã¡ãã«âïŒâïŒïŒïŒïŒâãžã¡ãã«â
ïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€ã«ïŒããªâïŒ
âã¡ãã«ããã«ã¢ãã ïŒïŒ®âãžã¡ãã«âïŒâïŒ1HâïŒïŒïŒïŒïŒâã
ãªã¢ãŸãŒã«âïŒâã€ã«ïŒããªâããã«ã¢ãã âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒ1Hâ
ïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€ã«ïŒããªãŒã
ãã«ã¢ãã ïŒâïŒïŒïŒïŒâãžã¡ãã«âïŒïŒïŒïŒïŒâããªã¢
ãŸãŒã«âïŒâã€ã«ïŒããªâããã«ã¢ãã ïŒâïŒïŒïŒïŒâãžã¡ãã«âïŒïŒïŒïŒïŒâããªã¢
ãŸãŒã«âïŒâã€ã«ïŒããªâé ªé žã¡ãã«ãšã¹ãã« ïŒâïŒ4HâïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâé ªé žã¡ãã«ãšã¹ãã« ïŒâïŒïŒâã¡ãã«â4HâïŒïŒïŒïŒïŒâããªã¢ãŸ
ãŒã«âïŒâã€ã«ïŒããªâé ªé žãšãã«ãšã¹ãã« ïŒâïŒïŒïŒïŒâãžã¡ãã«âïŒïŒïŒïŒïŒâããªã¢
ãŸãŒã«âïŒâã€ã«ïŒããªâé ªé ž ïŒâïŒ4HâïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâé ªé ž ïŒâïŒïŒïŒïŒâãžãšãã«âïŒïŒïŒïŒïŒâããªã¢
ãŸãŒã«âïŒâã€ã«ïŒããªâé ªé ž ïŒâïŒïŒïŒïŒâãžã¡ãã«âïŒïŒïŒïŒïŒâããªã¢
ãŸãŒã«âïŒâã€ã«ïŒããªâããããªã³é ž ïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«
âïŒâã€ã«ïŒããªâé ªé ž ïŒâïŒïŒâã¡ãã«â4HâïŒïŒïŒïŒïŒâããªã¢ãŸ
ãŒã«âïŒâã€ã«ïŒããªâé ªé ž æ¬çºæã®ååç©ã®ãã¡ãåèšåŒ(1)äžïŒºãïŒNH
ã§ããå Žåã«ã¯äžèšåŒã§ç€ºãããããã«ïŒçš®ã®äº
å€ç°æ§äœãååšãã眮æåºã®çš®é¡ããã®ä¿åç¶
æ ãããªãã¡æº¶æ¶²äžãããã¯åé¢ããç¶æ ãªã©ã«
ããããããã®åœ¢ã§å®å®ã«ååšãããã®ãšèãã
ããããæ¬çºæã¯ããããã¹ãŠã®ç°æ§äœãå å«ã
ãã æ¬çºæã®ååç©ã¯çš®ã ã®æ¹æ³ã§è£œé ãããäŸã
ã°äžèšåå¿åŒâïŒã«ç€ºãããæ¹æ³ã§å®¹æã«è£œé ã
ããã ãåŒäžR1ãR3ãR4ãããã³ïŒºã¯åèšã«åãã äžèšåå¿åŒâïŒã«ç€ºãããæ¹æ³ã¯ãäžè¬åŒ(2)ã§
è¡šããããã«ã«ãã³é žãšäžè¬åŒ(3)ã§è¡šããããã¢
ãã³ãšãéåžžã®ã¢ããçµåçæåå¿ã«ãŠåå¿ãã
ãæ¹æ³ã§ããã äžèšæ¹æ³ã§ã¯äžè¬åŒ(2)ã®ååç©ã«ä»£ããŠããã®
ã«ã«ããã·ã«åºã掻æ§åãããååç©ãçšããŠã
ããããŸããäžè¬åŒ(3)ã®ååç©ã«ä»£ããŠããã®ã¢
ããåºã掻æ§åãããååç©ãçšããŠããããã¢
ããçµåçæåå¿ãšããŠã¯ãå ¬ç¥ã®ã¢ããçµåç
æåå¿ã®æ¡ä»¶ã容æã«é©çšããããšãã§ãããäŸ
ãã°ã(ã€)æ··åé žç¡æ°Žç©æ³ãããªãã¡ã«ã«ãã³é ž(2)
ã«ããã«ã«ãã³é žã¢ã«ãã«ãšã¹ãã«ãåå¿ãããŠ
æ··åé žç¡æ°Žç©ãšããããã«ã¢ãã³(3)ãåå¿ããã
æ¹æ³ã(ã)掻æ§ãšã¹ãã«æ³ãããªãã¡ã«ã«ãã³é ž(2)
ããäŸãã°ïœâãããããšãã«ãšã¹ãã«ãâã
ãããã·ã³ãã¯é žã€ãããšã¹ãã«ãïŒâãããã
ã·ãã³ãŸããªã¢ãŸãŒã«âãšã¹ãã«ãªã©ã®æŽ»æ§ãšã¹
ãã«ãšããããã«ã¢ãã³(3)ãåå¿ãããæ¹æ³ã(ã)
ã«ã«ããžã€ããæ³ãããªãã¡ãã«ã«ãã³é ž(2)ã«ã¢
ãã³(3)ããäŸãã°ãžã·ã¯ãããã·ã«ã«ã«ããžã€ã
ããã«ã«ããã«ãžã€ãããŸãŒã«ãªã©ã®è±æ°Žå€ã®å
åšäžã«è±æ°Žçž®åãããæ¹æ³ã(ã)ã«ã«ãã³é žãã©ã€
ãæ³ãããªãã¡ãã«ã«ãã³é ž(2)ã®ãã©ã€ãååç©
ã«ã¢ãã³(3)ãåå¿ãããæ¹æ³ã(ã)ãã®ä»ã®æ¹æ³ãš
ããŠã«ã«ãã³é ž(2)ããäŸãã°ç¡æ°Žé ¢é žãªã©ã®è±æ°Ž
å€ã«ããã«ã«ãã³é žç¡æ°Žç©ãšããããã«ã¢ãã³(3)
ãåå¿ãããæ¹æ³ãã«ã«ãã³é ž(2)ãšãäŸãã°äœçŽ
ã¢ã«ã³ãŒã«ãšã®ãšã¹ãã«ã«ã¢ãã³(3)ãé«å§æž©äžã«
åå¿ãããæ¹æ³ãªã©ãæããããšãã§ããããã
ãã®ãã¡ã§æ··åé žç¡æ°Žç©æ³ããã³ã«ã«ãã³é žãã©
ã€ãæ³ã奜ãŸãããæ··åé žç¡æ°Žç©æ³ã«ãããŠäœ¿çš
ãããããã«ã«ãã³é žã¢ã«ãã«ãšã¹ãã«ãšããŠã¯
äŸãã°ã¯ããã®é žã¡ãã«ãããã¢ã®é žã¡ãã«ãã¯
ããã®é žãšãã«ãããã¢ã®é žãšãã«ãã¯ããã®é ž
ã€ãœããã«ãªã©ãæãããããæ··åé žç¡æ°Žç©ã¯é
åžžã®ã·ãšããã³âããŠãã³åå¿ã«ããåŸãããã
ããéåžžåé¢ããããšãªãã¢ãã³(3)ãšåå¿ããã
ããšã«ããæ¬çºæååç©ã補é ããããã·ãšãã
ã³ããŠãã³åå¿ã¯å¡©åºæ§ååç©ã®ååšäžã«è¡ãªã
ãããçšããããå¡©åºæ§ååç©ãšããŠã¯ã·ãšãã
ã³âããŠãã³åå¿ã«æ £çšã®ååç©ãçšããããäŸ
ãã°ãããªãšãã«ã¢ãã³ãããªã¡ãã«ã¢ãã³ãã
ãªãžã³ããžã¡ãã«ã¢ããªã³ãâã¡ãã«ã¢ã«ããª
ã³ãïŒïŒïŒâãžã¢ã¶ãã·ã¯ãã4.3.0ãããã³â
ïŒïŒDBNïŒãïŒïŒïŒâãžã¢ã¶ãã·ã¯ãã5.4.0ããŠ
ã³ãã»ã³âïŒïŒDBUïŒãïŒïŒïŒâãžã¢ã¶ãã·ã¯ã
ã2.2.2ããªã¯ã¿ã³ïŒDABCOïŒãªã©ã®ææ©å¡©åºã
çé žã«ãªãŠã ãçé žãããªãŠã ãçé žæ°ŽçŽ ã«ãªãŠ
ã ãçé žæ°ŽçŽ ãããªãŠã ãªã©ã®ç¡æ©å¡©åºãæãã
ããã該åå¿ã¯â20ã100âçšåºŠã奜ãŸããã¯ïŒ
ã50âã«ãããŠè¡ãªãããåå¿æéã¯ïŒåã10æ
éçšåºŠã§è¡ãªããããåŸãããæ··åé žç¡æ°Žç©ãšã¢
ãã³(3)ã®åå¿ã¯â20ã150âçšåºŠã奜ãŸããã¯10
ã50âã«ãããŠè¡ãªãããåå¿æéã¯ïŒåã10æ
éçšåºŠã®æ¡ä»¶äžã«è¡ãªããããæ··åé žç¡æ°Žç©æ³ã¯
äžè¬ã«æº¶åªäžã§è¡ãªããããçšãããã溶åªã¯æ··
åé žç¡æ°Žç©æ³ã«æ £çšã®æº¶åªããããã䜿çšå¯èœã§
ãããå ·äœçã«ã¯å¡©åã¡ãã¬ã³ãã¯ãããã«ã ã
ãžã¯ãããšã¿ã³ãªã©ã®ããã²ã³åçåæ°ŽçŽ é¡ãã
ã³ãŒã³ããã«ãšã³ããã·ã¬ã³ãªã©ã®è³éŠæçåæ°Ž
çŽ é¡ããžãšãã«ãšãŒãã«ãããã©ããããã©ã³ã
ãžã¡ããã·ãšã¿ã³ãªã©ã®ãšãŒãã«é¡ãé ¢é žã¡ã
ã«ãé ¢é žãšãã«ãªã©ã®ãšã¹ãã«é¡ããžã¡ãã«ãã«
ã ã¢ããããžã¡ãã«ã¹ã«ããã·ãããããµã¡ãã«
ãªã³é žããªã¢ãããªã©ã®éãããã³æ§æ¥µæ§æº¶åªãª
ã©ãæããããã該æ³ã«ãããã«ã«ãã³é ž(2)ãã
ãã«ã«ãã³é žã¢ã«ãã«ãšã¹ãã«ããã³ã¢ãã³(3)ã®
䜿çšå²åã¯éåžžãã«ã«ãã³é ž(2)ã«å¯ŸããŠããã«ã«
ãã³é žã¢ã«ãã«ãšã¹ãã«ããã³ã¢ãã³(3)ãå°ãªã
ãšãçã¢ã«çšåºŠã奜ãŸããã¯ïŒã1.5åã¢ã«äœ¿çš
ããã ã«ã«ãã³é žãã©ã€ãæ³ã¯ãã«ã«ãã³é ž(2)ã«ãã
ã²ã³åå€ãåå¿ãããŠãã«ã«ãã³é ž(2)ã®ãã©ã€ã
ååç©ãšããã®ã¡ãåŸãããã«ã«ãã³é žãã©ã€ã
ãåé¢ç²Ÿè£œããã¯åé¢ç²Ÿè£œããããšãªããã¢ãã³
(3)ãšåå¿ãããããšã«ããè¡ãªãããã ã«ã«ãã³é ž(2)ãšããã²ã³åå€ãšã®åå¿ã¯ãç¡æº¶
åªã§ããããã¯æº¶åªã®ååšäžã§ãè¡ãªãããã溶
åªãšããŠã¯ãåå¿ã«æªåœ±é¿ãäžããªããã®ã§ãã
ã°äœ¿çšã§ããäŸãã°ããã³ãŒã³ããã«ãšã³ããã·
ã¬ã³ãªã©ã®è³éŠæçåæ°ŽçŽ é¡ãã¯ãããã«ã ãå¡©
åã¡ãã¬ã³ãåå¡©åççŽ ãªã©ã®ããã²ã³åçåæ°Ž
çŽ é¡ããžãªããµã³ãããã©ããããã©ã³ããžãšã
ã«ãšãŒãã«ãªã©ã®ãšãŒãã«é¡ããžã¡ãã«ãã«ã ã¢
ãã³ããžã¡ãã«ã¹ã«ããã·ããªã©ã®éãããã³æ¥µ
æ§æº¶åªãäŸç€ºã§ãããããã²ã³åå€ãšããŠã¯ãã«
ã«ããã·åºã®æ°Žé žåºãããã²ã³ã«å€ããéåžžã®ã
ãã²ã³åå€ã䜿çšã§ããäŸãã°ãå¡©åããªãã«ã
ãªãã·å¡©åãªã³ããªãã·èåãªã³ãäºå¡©åãªã³ã
äºèåãªã³ãªã©ãäŸç€ºã§ããã ã«ã«ãã³é ž(2)ãšããã²ã³åå€ãšã®äœ¿çšå²åã¯ãš
ãã«éå®ããããé©å®éžæãããããç¡æº¶åªäžã§
åå¿ãè¡ãªãå Žåã«ã¯ãéåžžãåè ã«å¯ŸããŠåŸè
ã倧éå°éã溶åªäžã§åå¿ãè¡ãªãå Žåã«ã¯ãé
åžžãåè ã«å¯ŸããŠåŸè ãå°ãªããšãçã¢ã«éçš
床ã奜ãŸããã¯ïŒãïŒåã¢ã«éãçšããã°ããã
ãŸãããã®åå¿æž©åºŠããã³åå¿æéããšãã«éå®
ãããªãããéåžžã宀枩ã100âçšåºŠã奜ãŸãã
ã¯50ã80âã«ãŠ30åãïŒæéçšåºŠã§è¡ãªãããã ã«ã«ãã³é žãã©ã€ããšã¢ãã³(3)ãšåå¿ã¯ãè±ã
ãã²ã³åæ°ŽçŽ å€ã®ååšäžè¡ãªãããããã®è±ãã
ã²ã³åæ°ŽçŽ å€ãšããŠã¯ãéåžžå¡©åºæ§ååç©ãçšã
ããããå¡©åºæ§ååç©ãšããŠã¯å ¬ç¥ã®ãã®ãåºã
䜿çšã§ããäŸãã°ãæ°Žé žåãããªãŠã ãæ°Žé žåã«
ãªãŠã ãçé žãããªãŠã ãçé žã«ãªãŠã ãçé žæ°Ž
çŽ ãããªãŠã ãçé žæ°ŽçŽ ã«ãªãŠã ãçé žéãªã©ã®
ç¡æ©å¡©åºããããªãŠã ãã«ãªãŠã ãªã©ã®ã¢ã«ã«ãª
éå±ããããªãŠã ã¡ãã©ãŒãããããªãŠã ãšãã©
ãŒããªã©ã®ã¢ã«ã³ã©ãŒããããªãšãã«ã¢ãã³ãã
ãªãžã³ãïŒïŒ®âãžã¡ãã«ã¢ããªã³ãâã¡ãã«
ã¢ã«ããªã³ãïŒâãžã¡ãã«ã¢ããããªãžã³ãïŒïŒ
ïŒâãžã¢ã¶ãã·ã¯ãã4.3.0ãããã³âïŒïŒDBNïŒã
ïŒïŒïŒâãžã¢ã¶ãã·ã¯ãã5.4.0ããŠã³ãã»ã³â
ïŒïŒDBUïŒãïŒïŒïŒâãžã¢ã¶ãã·ã¯ãã2.2.2ïŒãª
ã¯ã¿ã³ïŒDABCOïŒãªã©ã®ææ©å¡©åºãæããã
ãããŸãã¢ãã³(3)èªèº«ãéå°ã«çšããŠè±ããã²ã³
åæ°ŽçŽ å€ã«å ŒçšããŠãããã該åå¿ã¯ç¡æº¶åªã§ã
ãããã¯æº¶åªã®ååšäžã§ãè¡ãªããã溶åªãšããŠ
ã¯åå¿ã«æªåœ±é¿ãäžããªãäžæŽ»æ§ã®ãã®ããã¹ãŠ
çšããããäŸãã°ã¯ãããã«ã ãå¡©åã¡ãã¬ã³ã
åå¡©åççŽ ãªã©ã®ããã²ã³åçåæ°ŽçŽ é¡ããžãšã
ã«ãšãŒãã«ãããã©ããããã©ã³ããžãªããµã³ãª
ã©ã®ãšãŒãã«é¡ããã³ãŒã³ããã«ãšã³ããã·ã¬ã³
ãªã©ã®è³éŠæçåæ°ŽçŽ é¡ãé ¢é žã¡ãã«ãé ¢é žãšã
ã«ãªã©ã®ãšã¹ãã«é¡ãïŒïŒ®âãžã¡ãã«ãã«ã ã¢
ããããžã¡ãã«ã¹ã«ãããµã€ãããããµã¡ãã«ãª
ã³é žããªã¢ãããªã©ã®éãããã³æ§æ¥µæ§æº¶åªãªã©
ãæããããã ã«ã«ãã³é žãã©ã€ããšã¢ãã³(3)ã®äœ¿çšå²åã¯ãš
ãã«éå®ãªãé©å®éžæãããããç¡æº¶åªäžã§åå¿
ãè¡ãªãå Žåã«ã¯ãåè ã«å¯ŸããŠåŸè ãé垞倧é
å°éã溶åªäžã§åå¿ãè¡ãªãå Žåã«ã¯ãéåžžãåŸ
è ãå°ãªããšãçã¢ã«éçšåºŠã奜ãŸããã¯ãçã¢
ã«ãïŒåã¢ã«éçšããã°ããããŸããåå¿æž©åºŠã
ãã³åå¿æéããšãã«éå®ãããªãããéåžžãâ
30âã100âçšåºŠã奜ãŸããã¯ãïŒã50âã«ãŠ30
åã12æéçšåºŠã§è¡ãªãããã æ¬çºæã®ååç©(1)ã¯ãäŸãã°åå¿åŒâïŒã«ç€ºã
æ¹æ³ã«ãã€ãŠè£œé ã§ããã ãåŒäžãX1ããã³X2ã®äžæ¹ã¯ããã²ã³ååã
ä»æ¹ã¯ã¡ã«ã«ããåºãŸãã¯åº
åºãã¯äœçŽã¢ã«ãã¬ã³åºã瀺ãããŸããã¯é ž
çŽ ååãç¡«é»ååãŸãã¯ïŒ®âR5ã瀺ããR5ã¯
æ°ŽçŽ ååãŸãã¯äœçŽã¢ã«ãã«åºã瀺ãããã ãã
R1ãæ°ŽçŽ åå瀺ããšãã¯NHã瀺ããR1ã
äœçŽã¢ã«ãã«åºã瀺ããšãã¯ç¡«é»ååã§ãã€ãŠ
ã¯ãªãããR1ãã¢ããåºã瀺ããšãã¯ç¡«é»å
åã瀺ããã ã§è¡šããããã æ¬çºæã®ååç©ã¯ãæ朰çäœçšããã³æ¶çäœçš
ãæããæ朰çå€ããã³æ¶çå€ãšããŠæçšã§ã
ãã æ¬æ现æžã«ãããŠäœçŽã¢ã«ãã«åºãšããŠã¯ãäŸ
ãã°ã¡ãã«ããšãã«ããããã«ãã€ãœãããã«ã
ããã«ãtertâããã«ããã³ãã«ãããã·ã«åºãª
ã©ãäŸç€ºã§ãããã·ã¯ãã¢ã«ãã«åºãšããŠã¯ãäŸ
ãã°ãã·ã¯ããããã«ãã·ã¯ãããã«ãã·ã¯ãã
ã³ãã«ãã·ã¯ãããã·ã«ãã·ã¯ããããã«ãã·ã¯
ããªã¯ãã«ãªã©ãäŸç€ºã§ãããäœçŽã¢ã«ãã¬ã³åº
ãšããŠã¯ãäŸãã°ãã¡ãã¬ã³ããšãã¬ã³ãããªã¡
ãã¬ã³ãããã©ã¡ãã¬ã³ããã³ã¿ã¡ãã¬ã³ããã
ãµã¡ãã¬ã³ãã¡ãã«ã¡ãã¬ã³ïŒâã¡ãã«ããªã¡ã
ã¬ã³ãïŒïŒïŒâãžã¡ãã«ããªã¡ãã¬ã³ãïŒâã¡ã
ã«ããªã¡ãã¬ã³åºãªã©ãæããããäœçŽã¢ã«ã³ã
ã·åºãšããŠã¯ãäŸãã°ãã¡ããã·ããšããã·ãã
ãããã·ãã€ãœããããã·ããããã·ãtertâã
ããã·ããã³ãã«ãªãã·ãããã·ã«ãªãã·åºãªã©
ãäŸç€ºã§ããã æ¬çºæã®ä»£è¡šçãªååç©ãšããŠã¯ãäŸãã°äžèš
ã®ãã®ãæããããã âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâããã«ã¢ããã âã¡ãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâããã«ã¢ãã âã·ã¯ãããã·ã«âïŒâïŒïŒâã¡ãã«âïŒïŒ
ïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâã
ãã«ã¢ãã âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ãšãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâããã«ã¢ãã âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâããããªã³ã¢ãã âã¡ãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâã¢ã»ãã¢ãã âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâãã¬ã«ã¢ãã âã¡ãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâããã¿ã³ã¢ãã âã¡ãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâïŒâã¡ãã«ããã«ã¢ãã âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ããã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâããããªã³ã¢ãã ïŒïŒ®âãžã·ã¯ãããã·ã«âïŒâïŒïŒâã¡ãã«
âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€ã«ïŒã
ãªâããã«ã¢ãã âã·ã¯ãããã·ã«ââã·ã¯ããªã¯ãã«âïŒ
âïŒïŒâã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«
âïŒâã€ã«ïŒããªâããã«ã¢ãã ïŒïŒ®âãžã¡ãã«âïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒ
ïŒâãªããµãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâããã«
ã¢ãã ïŒïŒ®âãžãšãã«âïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒ
ïŒâãªããµãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâããã«
ã¢ãã ïŒïŒ®âãžã€ãœãããã«âïŒâïŒïŒâã¡ãã«â
ïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€ã«ïŒããª
âããã«ã¢ãã ïŒïŒ®âãžããã·ã«âïŒâïŒïŒâã¡ãã«âïŒïŒ
ïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâã
ãã«ã¢ãã âã¡ãã«ââãšãã«âïŒâïŒïŒâã¡ãã«â
ïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€ã«ïŒããª
âããã«ã¢ãã ïŒïŒ®âãžãšãã«âïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒ
ïŒâãªããµãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâãã¬ã«
ã¢ãã ïŒïŒ®âãžãšãã«âïŒâïŒïŒâã€ãœãããã«â
ïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€ã«ïŒããª
âããã«ã¢ãã ïŒïŒ®âãžã¡ãã«âïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒ
ïŒâãªããµãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâïŒâã¡
ãã«ããã«ã¢ãã ïŒïŒ®âãžãšãã«âïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒ
ïŒâãªããµãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâããã
ãªã³ã¢ãã âãšãã«âïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒïŒâ
ãªããµãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâããã«ã¢ã
ã ïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸ
ãŒã«âïŒâã€ã«ïŒããªâããã«ã¢ãã ïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸ
ãŒã«âïŒâã€ã«ïŒããªâé ªé žã¡ãã«ãšã¹ãã« ïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸ
ãŒã«âïŒâã€ã«ïŒããªâããããªã³é žã€ãœããã
ã«ãšã¹ãã« ïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸ
ãŒã«âïŒâã€ã«ïŒããªâåèé žã¡ãã«ãšã¹ãã« ïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸ
ãŒã«âïŒâã€ã«ïŒããªâé ªé ž ïŒâïŒïŒâãšãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸ
ãŒã«âïŒâã€ã«ïŒããªâé ªé ž ïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸ
ãŒã«âïŒâã€ã«ïŒããªâåèé ž âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâããã«ã¢ãã âããã«ââã·ã¯ããªã¯ãã«âïŒâïŒïŒâ
ã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâããã«ã¢ãã âã¡ãã«ââã·ã¯ããã³ãã«âïŒâïŒïŒâ
ã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâããã«ã¢ãã âã¡ãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâããã«ã¢ãã âã·ã¯ãããã·ã«âïŒâïŒïŒâã¢ããâïŒïŒ
ïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâãã
ã«ã¢ãã âã¡ãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâããããªã³ã¢ãã âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâã¢ã»ãã¢ãã âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâã¡ãã«ããã«ã¢ãã âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâããããªã³ã¢ãã ïŒïŒ®âãžã·ã¯ãããã·ã«âïŒâïŒïŒâã¢ãã
âïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒããª
âããã«ã¢ãã ïŒïŒ®âãžã¡ãã«âïŒâïŒïŒâã¢ããâïŒïŒïŒïŒ
ïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâããã«ã¢
ãã ïŒïŒ®âãžãšãã«âïŒâïŒïŒâã¢ããâïŒïŒïŒïŒ
ïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâããã«ã¢
ãã ïŒïŒ®âãžããã·ã«âïŒâïŒïŒâã¢ããâïŒïŒ
ïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâãã
ã«ã¢ãã âã¡ãã«ââãšãã«âïŒâïŒïŒâã¢ããâ
ïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâ
ããã«ã¢ãã ïŒïŒ®âãžãšãã«âïŒâïŒïŒâã¢ããâïŒïŒïŒïŒ
ïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâãã¬ã«ã¢
ãã ïŒïŒ®âãžã¡ãã«âïŒâïŒïŒâã¢ããâïŒïŒïŒïŒ
ïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâïŒâã¡ã
ã«ããã«ã¢ãã ïŒïŒ®âãžãšãã«âïŒâïŒïŒâã¢ããâïŒïŒïŒïŒ
ïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâããããª
ã³ã¢ãã âãšãã«âïŒâïŒïŒâã¢ããâïŒïŒïŒïŒïŒâ
ãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâããã«ã¢ãã ïŒâïŒïŒâã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒ
ã«âïŒâã€ã«ïŒããªâããã«ã¢ãã ïŒâïŒïŒâã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒ
ã«âïŒâã€ã«ïŒããªâé ªé žã¡ãã«ãšã¹ãã« ïŒâïŒïŒâã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒ
ã«âïŒâã€ã«ïŒããªâããããªã³é žã€ãœãããã«
ãšã¹ãã« ïŒâïŒïŒâã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒ
ã«âïŒâã€ã«ïŒããªâé ªé žãšãã«ãšã¹ãã« ïŒâïŒïŒâã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒ
ã«âïŒâã€ã«ïŒããªâåèé žã¡ãã«ãšã¹ãã« ïŒâïŒïŒâã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒ
ã«âïŒâã€ã«ïŒããªâé ªé ž ïŒâïŒïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒ
ããªâé ªé ž âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒïŒ
ïŒâãžã¡ãã«âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâ
ã€ã«ïŒããªâããã«ã¢ãã âããã«ââã·ã¯ããªã¯ãã«âïŒâïŒïŒïŒ
ïŒâãžã¡ãã«âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâ
ã€ã«ïŒããªâããã«ã¢ãã âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
ã¡ãã«âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€ã«ïŒ
ããªâããã«ã¢ãã âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒ4Hâ
ïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€ã«ïŒâããã«
ã¢ãã âã¡ãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒïŒ
ïŒâãžãšãã«âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâ
ã€ã«ïŒããªâããã«ã¢ãã âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâ
tertâããã«âïŒâã¡ãã«âïŒïŒïŒïŒïŒâããªã¢
ãŸãŒã«âïŒâã€ã«ïŒããªâããã«ã¢ãã âã·ã¯ãããã·ã«âïŒâïŒïŒïŒïŒâãžã¡ãã«
âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€ã«ïŒããªâ
ããã«ã¢ãã âã¡ãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒïŒ
ïŒâãžã¡ãã«âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâ
ã€ã«ïŒããªâããããªã³ã¢ãã âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒïŒ
ïŒâãžã¡ãã«âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâ
ã€ã«ïŒããªâã¢ã»ãã¢ãã âã¡ãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒïŒ
ïŒâãžã¡ãã«âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâ
ã€ã«ïŒããªâãã¬ã«ã¢ãã âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒïŒ
ïŒâãžã¡ãã«âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâ
ã€ã«ïŒããªâïŒâã¡ãã«ããã«ã¢ãã ïŒïŒ®âãžã·ã¯ãããã·ã«âïŒâïŒïŒïŒïŒâãž
ã¡ãã«âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€ã«ïŒ
ããªâããã«ã¢ãã ïŒïŒ®âãžã¡ãã«âïŒâïŒïŒïŒïŒâãžã¡ãã«â
ïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€ã«ïŒããªâã
ãã«ã¢ãã ïŒïŒ®âãžãšãã«âïŒâïŒïŒïŒïŒâãžã¡ãã«â
ïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€ã«ïŒããªâã
ãã«ã¢ãã ïŒïŒ®âãžããã·ã«âïŒâïŒïŒïŒïŒâãžã¡ãã«
âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€ã«ïŒããªâ
ããã«ã¢ãã âã¡ãã«ââãšãã«âïŒâïŒïŒïŒïŒâãžã¡
ãã«âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€ã«ïŒã
ãªâããã«ã¢ãã ïŒïŒ®âãžãšãã«âïŒâïŒïŒïŒïŒâãžãšãã«â
ïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€ã«ïŒããªâã
ãã«ã¢ãã ïŒïŒ®âãžã¡ãã«âïŒâïŒ4HâïŒïŒïŒïŒïŒâã
ãªã¢ãŸãŒã«âïŒâã€ã«ïŒããªâããã«ã¢ãã ïŒïŒ®âãžã¡ãã«âïŒâïŒïŒïŒïŒâãžã¡ãã«â
ïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€ã«ïŒããªâïŒ
âã¡ãã«ããã«ã¢ãã ïŒïŒ®âãžã¡ãã«âïŒâïŒ1HâïŒïŒïŒïŒïŒâã
ãªã¢ãŸãŒã«âïŒâã€ã«ïŒããªâããã«ã¢ãã âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒ1Hâ
ïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€ã«ïŒããªãŒã
ãã«ã¢ãã ïŒâïŒïŒïŒïŒâãžã¡ãã«âïŒïŒïŒïŒïŒâããªã¢
ãŸãŒã«âïŒâã€ã«ïŒããªâããã«ã¢ãã ïŒâïŒïŒïŒïŒâãžã¡ãã«âïŒïŒïŒïŒïŒâããªã¢
ãŸãŒã«âïŒâã€ã«ïŒããªâé ªé žã¡ãã«ãšã¹ãã« ïŒâïŒ4HâïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâé ªé žã¡ãã«ãšã¹ãã« ïŒâïŒïŒâã¡ãã«â4HâïŒïŒïŒïŒïŒâããªã¢ãŸ
ãŒã«âïŒâã€ã«ïŒããªâé ªé žãšãã«ãšã¹ãã« ïŒâïŒïŒïŒïŒâãžã¡ãã«âïŒïŒïŒïŒïŒâããªã¢
ãŸãŒã«âïŒâã€ã«ïŒããªâé ªé ž ïŒâïŒ4HâïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâé ªé ž ïŒâïŒïŒïŒïŒâãžãšãã«âïŒïŒïŒïŒïŒâããªã¢
ãŸãŒã«âïŒâã€ã«ïŒããªâé ªé ž ïŒâïŒïŒïŒïŒâãžã¡ãã«âïŒïŒïŒïŒïŒâããªã¢
ãŸãŒã«âïŒâã€ã«ïŒããªâããããªã³é ž ïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«
âïŒâã€ã«ïŒããªâé ªé ž ïŒâïŒïŒâã¡ãã«â4HâïŒïŒïŒïŒïŒâããªã¢ãŸ
ãŒã«âïŒâã€ã«ïŒããªâé ªé ž æ¬çºæã®ååç©ã®ãã¡ãåèšåŒ(1)äžïŒºãïŒNH
ã§ããå Žåã«ã¯äžèšåŒã§ç€ºãããããã«ïŒçš®ã®äº
å€ç°æ§äœãååšãã眮æåºã®çš®é¡ããã®ä¿åç¶
æ ãããªãã¡æº¶æ¶²äžãããã¯åé¢ããç¶æ ãªã©ã«
ããããããã®åœ¢ã§å®å®ã«ååšãããã®ãšèãã
ããããæ¬çºæã¯ããããã¹ãŠã®ç°æ§äœãå å«ã
ãã æ¬çºæã®ååç©ã¯çš®ã ã®æ¹æ³ã§è£œé ãããäŸã
ã°äžèšåå¿åŒâïŒã«ç€ºãããæ¹æ³ã§å®¹æã«è£œé ã
ããã ãåŒäžR1ãR3ãR4ãããã³ïŒºã¯åèšã«åãã äžèšåå¿åŒâïŒã«ç€ºãããæ¹æ³ã¯ãäžè¬åŒ(2)ã§
è¡šããããã«ã«ãã³é žãšäžè¬åŒ(3)ã§è¡šããããã¢
ãã³ãšãéåžžã®ã¢ããçµåçæåå¿ã«ãŠåå¿ãã
ãæ¹æ³ã§ããã äžèšæ¹æ³ã§ã¯äžè¬åŒ(2)ã®ååç©ã«ä»£ããŠããã®
ã«ã«ããã·ã«åºã掻æ§åãããååç©ãçšããŠã
ããããŸããäžè¬åŒ(3)ã®ååç©ã«ä»£ããŠããã®ã¢
ããåºã掻æ§åãããååç©ãçšããŠããããã¢
ããçµåçæåå¿ãšããŠã¯ãå ¬ç¥ã®ã¢ããçµåç
æåå¿ã®æ¡ä»¶ã容æã«é©çšããããšãã§ãããäŸ
ãã°ã(ã€)æ··åé žç¡æ°Žç©æ³ãããªãã¡ã«ã«ãã³é ž(2)
ã«ããã«ã«ãã³é žã¢ã«ãã«ãšã¹ãã«ãåå¿ãããŠ
æ··åé žç¡æ°Žç©ãšããããã«ã¢ãã³(3)ãåå¿ããã
æ¹æ³ã(ã)掻æ§ãšã¹ãã«æ³ãããªãã¡ã«ã«ãã³é ž(2)
ããäŸãã°ïœâãããããšãã«ãšã¹ãã«ãâã
ãããã·ã³ãã¯é žã€ãããšã¹ãã«ãïŒâãããã
ã·ãã³ãŸããªã¢ãŸãŒã«âãšã¹ãã«ãªã©ã®æŽ»æ§ãšã¹
ãã«ãšããããã«ã¢ãã³(3)ãåå¿ãããæ¹æ³ã(ã)
ã«ã«ããžã€ããæ³ãããªãã¡ãã«ã«ãã³é ž(2)ã«ã¢
ãã³(3)ããäŸãã°ãžã·ã¯ãããã·ã«ã«ã«ããžã€ã
ããã«ã«ããã«ãžã€ãããŸãŒã«ãªã©ã®è±æ°Žå€ã®å
åšäžã«è±æ°Žçž®åãããæ¹æ³ã(ã)ã«ã«ãã³é žãã©ã€
ãæ³ãããªãã¡ãã«ã«ãã³é ž(2)ã®ãã©ã€ãååç©
ã«ã¢ãã³(3)ãåå¿ãããæ¹æ³ã(ã)ãã®ä»ã®æ¹æ³ãš
ããŠã«ã«ãã³é ž(2)ããäŸãã°ç¡æ°Žé ¢é žãªã©ã®è±æ°Ž
å€ã«ããã«ã«ãã³é žç¡æ°Žç©ãšããããã«ã¢ãã³(3)
ãåå¿ãããæ¹æ³ãã«ã«ãã³é ž(2)ãšãäŸãã°äœçŽ
ã¢ã«ã³ãŒã«ãšã®ãšã¹ãã«ã«ã¢ãã³(3)ãé«å§æž©äžã«
åå¿ãããæ¹æ³ãªã©ãæããããšãã§ããããã
ãã®ãã¡ã§æ··åé žç¡æ°Žç©æ³ããã³ã«ã«ãã³é žãã©
ã€ãæ³ã奜ãŸãããæ··åé žç¡æ°Žç©æ³ã«ãããŠäœ¿çš
ãããããã«ã«ãã³é žã¢ã«ãã«ãšã¹ãã«ãšããŠã¯
äŸãã°ã¯ããã®é žã¡ãã«ãããã¢ã®é žã¡ãã«ãã¯
ããã®é žãšãã«ãããã¢ã®é žãšãã«ãã¯ããã®é ž
ã€ãœããã«ãªã©ãæãããããæ··åé žç¡æ°Žç©ã¯é
åžžã®ã·ãšããã³âããŠãã³åå¿ã«ããåŸãããã
ããéåžžåé¢ããããšãªãã¢ãã³(3)ãšåå¿ããã
ããšã«ããæ¬çºæååç©ã補é ããããã·ãšãã
ã³ããŠãã³åå¿ã¯å¡©åºæ§ååç©ã®ååšäžã«è¡ãªã
ãããçšããããå¡©åºæ§ååç©ãšããŠã¯ã·ãšãã
ã³âããŠãã³åå¿ã«æ £çšã®ååç©ãçšããããäŸ
ãã°ãããªãšãã«ã¢ãã³ãããªã¡ãã«ã¢ãã³ãã
ãªãžã³ããžã¡ãã«ã¢ããªã³ãâã¡ãã«ã¢ã«ããª
ã³ãïŒïŒïŒâãžã¢ã¶ãã·ã¯ãã4.3.0ãããã³â
ïŒïŒDBNïŒãïŒïŒïŒâãžã¢ã¶ãã·ã¯ãã5.4.0ããŠ
ã³ãã»ã³âïŒïŒDBUïŒãïŒïŒïŒâãžã¢ã¶ãã·ã¯ã
ã2.2.2ããªã¯ã¿ã³ïŒDABCOïŒãªã©ã®ææ©å¡©åºã
çé žã«ãªãŠã ãçé žãããªãŠã ãçé žæ°ŽçŽ ã«ãªãŠ
ã ãçé žæ°ŽçŽ ãããªãŠã ãªã©ã®ç¡æ©å¡©åºãæãã
ããã該åå¿ã¯â20ã100âçšåºŠã奜ãŸããã¯ïŒ
ã50âã«ãããŠè¡ãªãããåå¿æéã¯ïŒåã10æ
éçšåºŠã§è¡ãªããããåŸãããæ··åé žç¡æ°Žç©ãšã¢
ãã³(3)ã®åå¿ã¯â20ã150âçšåºŠã奜ãŸããã¯10
ã50âã«ãããŠè¡ãªãããåå¿æéã¯ïŒåã10æ
éçšåºŠã®æ¡ä»¶äžã«è¡ãªããããæ··åé žç¡æ°Žç©æ³ã¯
äžè¬ã«æº¶åªäžã§è¡ãªããããçšãããã溶åªã¯æ··
åé žç¡æ°Žç©æ³ã«æ £çšã®æº¶åªããããã䜿çšå¯èœã§
ãããå ·äœçã«ã¯å¡©åã¡ãã¬ã³ãã¯ãããã«ã ã
ãžã¯ãããšã¿ã³ãªã©ã®ããã²ã³åçåæ°ŽçŽ é¡ãã
ã³ãŒã³ããã«ãšã³ããã·ã¬ã³ãªã©ã®è³éŠæçåæ°Ž
çŽ é¡ããžãšãã«ãšãŒãã«ãããã©ããããã©ã³ã
ãžã¡ããã·ãšã¿ã³ãªã©ã®ãšãŒãã«é¡ãé ¢é žã¡ã
ã«ãé ¢é žãšãã«ãªã©ã®ãšã¹ãã«é¡ããžã¡ãã«ãã«
ã ã¢ããããžã¡ãã«ã¹ã«ããã·ãããããµã¡ãã«
ãªã³é žããªã¢ãããªã©ã®éãããã³æ§æ¥µæ§æº¶åªãª
ã©ãæããããã該æ³ã«ãããã«ã«ãã³é ž(2)ãã
ãã«ã«ãã³é žã¢ã«ãã«ãšã¹ãã«ããã³ã¢ãã³(3)ã®
䜿çšå²åã¯éåžžãã«ã«ãã³é ž(2)ã«å¯ŸããŠããã«ã«
ãã³é žã¢ã«ãã«ãšã¹ãã«ããã³ã¢ãã³(3)ãå°ãªã
ãšãçã¢ã«çšåºŠã奜ãŸããã¯ïŒã1.5åã¢ã«äœ¿çš
ããã ã«ã«ãã³é žãã©ã€ãæ³ã¯ãã«ã«ãã³é ž(2)ã«ãã
ã²ã³åå€ãåå¿ãããŠãã«ã«ãã³é ž(2)ã®ãã©ã€ã
ååç©ãšããã®ã¡ãåŸãããã«ã«ãã³é žãã©ã€ã
ãåé¢ç²Ÿè£œããã¯åé¢ç²Ÿè£œããããšãªããã¢ãã³
(3)ãšåå¿ãããããšã«ããè¡ãªãããã ã«ã«ãã³é ž(2)ãšããã²ã³åå€ãšã®åå¿ã¯ãç¡æº¶
åªã§ããããã¯æº¶åªã®ååšäžã§ãè¡ãªãããã溶
åªãšããŠã¯ãåå¿ã«æªåœ±é¿ãäžããªããã®ã§ãã
ã°äœ¿çšã§ããäŸãã°ããã³ãŒã³ããã«ãšã³ããã·
ã¬ã³ãªã©ã®è³éŠæçåæ°ŽçŽ é¡ãã¯ãããã«ã ãå¡©
åã¡ãã¬ã³ãåå¡©åççŽ ãªã©ã®ããã²ã³åçåæ°Ž
çŽ é¡ããžãªããµã³ãããã©ããããã©ã³ããžãšã
ã«ãšãŒãã«ãªã©ã®ãšãŒãã«é¡ããžã¡ãã«ãã«ã ã¢
ãã³ããžã¡ãã«ã¹ã«ããã·ããªã©ã®éãããã³æ¥µ
æ§æº¶åªãäŸç€ºã§ãããããã²ã³åå€ãšããŠã¯ãã«
ã«ããã·åºã®æ°Žé žåºãããã²ã³ã«å€ããéåžžã®ã
ãã²ã³åå€ã䜿çšã§ããäŸãã°ãå¡©åããªãã«ã
ãªãã·å¡©åãªã³ããªãã·èåãªã³ãäºå¡©åãªã³ã
äºèåãªã³ãªã©ãäŸç€ºã§ããã ã«ã«ãã³é ž(2)ãšããã²ã³åå€ãšã®äœ¿çšå²åã¯ãš
ãã«éå®ããããé©å®éžæãããããç¡æº¶åªäžã§
åå¿ãè¡ãªãå Žåã«ã¯ãéåžžãåè ã«å¯ŸããŠåŸè
ã倧éå°éã溶åªäžã§åå¿ãè¡ãªãå Žåã«ã¯ãé
åžžãåè ã«å¯ŸããŠåŸè ãå°ãªããšãçã¢ã«éçš
床ã奜ãŸããã¯ïŒãïŒåã¢ã«éãçšããã°ããã
ãŸãããã®åå¿æž©åºŠããã³åå¿æéããšãã«éå®
ãããªãããéåžžã宀枩ã100âçšåºŠã奜ãŸãã
ã¯50ã80âã«ãŠ30åãïŒæéçšåºŠã§è¡ãªãããã ã«ã«ãã³é žãã©ã€ããšã¢ãã³(3)ãšåå¿ã¯ãè±ã
ãã²ã³åæ°ŽçŽ å€ã®ååšäžè¡ãªãããããã®è±ãã
ã²ã³åæ°ŽçŽ å€ãšããŠã¯ãéåžžå¡©åºæ§ååç©ãçšã
ããããå¡©åºæ§ååç©ãšããŠã¯å ¬ç¥ã®ãã®ãåºã
䜿çšã§ããäŸãã°ãæ°Žé žåãããªãŠã ãæ°Žé žåã«
ãªãŠã ãçé žãããªãŠã ãçé žã«ãªãŠã ãçé žæ°Ž
çŽ ãããªãŠã ãçé žæ°ŽçŽ ã«ãªãŠã ãçé žéãªã©ã®
ç¡æ©å¡©åºããããªãŠã ãã«ãªãŠã ãªã©ã®ã¢ã«ã«ãª
éå±ããããªãŠã ã¡ãã©ãŒãããããªãŠã ãšãã©
ãŒããªã©ã®ã¢ã«ã³ã©ãŒããããªãšãã«ã¢ãã³ãã
ãªãžã³ãïŒïŒ®âãžã¡ãã«ã¢ããªã³ãâã¡ãã«
ã¢ã«ããªã³ãïŒâãžã¡ãã«ã¢ããããªãžã³ãïŒïŒ
ïŒâãžã¢ã¶ãã·ã¯ãã4.3.0ãããã³âïŒïŒDBNïŒã
ïŒïŒïŒâãžã¢ã¶ãã·ã¯ãã5.4.0ããŠã³ãã»ã³â
ïŒïŒDBUïŒãïŒïŒïŒâãžã¢ã¶ãã·ã¯ãã2.2.2ïŒãª
ã¯ã¿ã³ïŒDABCOïŒãªã©ã®ææ©å¡©åºãæããã
ãããŸãã¢ãã³(3)èªèº«ãéå°ã«çšããŠè±ããã²ã³
åæ°ŽçŽ å€ã«å ŒçšããŠãããã該åå¿ã¯ç¡æº¶åªã§ã
ãããã¯æº¶åªã®ååšäžã§ãè¡ãªããã溶åªãšããŠ
ã¯åå¿ã«æªåœ±é¿ãäžããªãäžæŽ»æ§ã®ãã®ããã¹ãŠ
çšããããäŸãã°ã¯ãããã«ã ãå¡©åã¡ãã¬ã³ã
åå¡©åççŽ ãªã©ã®ããã²ã³åçåæ°ŽçŽ é¡ããžãšã
ã«ãšãŒãã«ãããã©ããããã©ã³ããžãªããµã³ãª
ã©ã®ãšãŒãã«é¡ããã³ãŒã³ããã«ãšã³ããã·ã¬ã³
ãªã©ã®è³éŠæçåæ°ŽçŽ é¡ãé ¢é žã¡ãã«ãé ¢é žãšã
ã«ãªã©ã®ãšã¹ãã«é¡ãïŒïŒ®âãžã¡ãã«ãã«ã ã¢
ããããžã¡ãã«ã¹ã«ãããµã€ãããããµã¡ãã«ãª
ã³é žããªã¢ãããªã©ã®éãããã³æ§æ¥µæ§æº¶åªãªã©
ãæããããã ã«ã«ãã³é žãã©ã€ããšã¢ãã³(3)ã®äœ¿çšå²åã¯ãš
ãã«éå®ãªãé©å®éžæãããããç¡æº¶åªäžã§åå¿
ãè¡ãªãå Žåã«ã¯ãåè ã«å¯ŸããŠåŸè ãé垞倧é
å°éã溶åªäžã§åå¿ãè¡ãªãå Žåã«ã¯ãéåžžãåŸ
è ãå°ãªããšãçã¢ã«éçšåºŠã奜ãŸããã¯ãçã¢
ã«ãïŒåã¢ã«éçšããã°ããããŸããåå¿æž©åºŠã
ãã³åå¿æéããšãã«éå®ãããªãããéåžžãâ
30âã100âçšåºŠã奜ãŸããã¯ãïŒã50âã«ãŠ30
åã12æéçšåºŠã§è¡ãªãããã æ¬çºæã®ååç©(1)ã¯ãäŸãã°åå¿åŒâïŒã«ç€ºã
æ¹æ³ã«ãã€ãŠè£œé ã§ããã ãåŒäžãX1ããã³X2ã®äžæ¹ã¯ããã²ã³ååã
ä»æ¹ã¯ã¡ã«ã«ããåºãŸãã¯åº
ãåŒãã
瀺ããR1ãR2ãããã³ïŒºã¯åèšã«åãã
åå¿åŒâïŒã«ãããŠãååç©(4)ãšã¢ã«ã«ã³ã«ã«
ãã³é žèªå°äœ(5)ãšã®çž®ååå¿ã¯ãéåžžãå¡©åºæ§å
åç©ãçž®åå€ãšããŠçšããŠè¡ãªããã該瞮åå€ãš
ããŠã¯åèšåå¿åŒâïŒã§ç€ºãããåå¿ã«ãããŠçš
ãããããã®ãšåãå¡©åºæ§ååç©ãæããããã
該åå¿ã¯ç¡æº¶åªã§ããããã¯æº¶åªã®ååšäžã§ãè¡
ãªããã溶åªãšããŠã¯åå¿ã«æªåœ±é¿ãäžããªãäž
掻æ§ãªãã®ããã¹ãŠçšããããäŸãã°ãã¡ã¿ããŒ
ã«ããšã¿ããŒã«ããããããŒã«ããã¿ããŒã«ããš
ãã¬ã³ã°ãªã³ãŒã«ãªã©ã®ã¢ã«ã³ãŒã«é¡ããžãšãã«
ãšãŒãã«ãããã©ããããã©ã³ããžãªããµã³ãã¢
ãã°ã©ã€ã ããžã°ã©ã€ã ãªã©ã®ãšãŒãã«é¡ãã¢ã»
ãã³ãã¡ãã«ãšãã«ã±ãã³ãªã©ã®ã±ãã³é¡ããã³
ãŒã³ããã«ãšã³ããã·ã¬ã³ãªã©ã®è³éŠæçåæ°ŽçŽ
é¡ãé ¢é žã¡ãã«ãé ¢é žãšãã«ãªã©ã®ãšã¹ãã«é¡ã
ïŒïŒ®âãžã¡ãã«ãã«ã ã¢ããããžã¡ãã«ã¹ã«ã
ããµã€ãããããµã¡ãã«ãªã³é žããªã¢ãããªã©ã®
éãããã³æ§æ¥µæ§æº¶åªãªã©ãæããããããŸã該
åå¿ã¯ãšãŠåãããªãŠã ããšãŠåã«ãªãŠã ãªã©ã®
éå±ãšãŠåç©ã®ååšäžã«è¡ãªãã®ãæå©ã§ããã
äžèšæ¹æ³ã«ãããååç©(4)ã«å¯Ÿããååç©(5)ã®äœ¿
çšå²åã¯ãšãã«éå®ããããåºç¯å²ã®äžããé©å®
ã«éžæãããããåå¿ãç¡æº¶åªäžã«è¡ãªãå Žåã«
ã¯ãåè ã«å¯ŸããŠåŸè ãé垞倧éå°éã溶åªäžã§
è¡ãªãå Žåã«ã¯ãéåžžãåè ã«å¯ŸããŠåŸè ãçã¢
ã«ãïŒåã¢ã«çšåºŠã奜ãŸããã¯çã¢ã«ãïŒåã¢ã«
éã«ãŠçšããã®ãæãŸããããŸãããã®åå¿æž©åºŠ
ããšãã«éå®ãããªãããéåžžãâ30âã200âçš
床ã奜ãŸããã¯ïŒã160âã§è¡ãªããããåå¿æ
éã¯éåžžïŒã30æéçšåºŠã§ããã ããã«ãæ¬çºæååç©ã®ãã¡ãR2ãäœçŽã¢ã«
ã³ãã·åºã瀺ãååç©ïŒ1bïŒãããã³R2ãæ°Žé žåº
ã瀺ãååç©(2)ã¯ãäžèšåå¿åŒâïŒã«ç€ºãããš
ããåååç©ãå æ°Žå解åå¿ãŸãã¯ãšã¹ãã«åå
å¿ã«ä»ããããšã«ããçžäºã«å€æã§ããã ãåŒäžãR1ãããã³ïŒºã¯åèšãšåããR5ã¯
äœçŽã¢ã«ãã«åºã瀺ãã ååç©ïŒ1bïŒã®å æ°Žå解åå¿ã¯åžžæ³ã«ããè¡
ãªãããäŸãã°æ°Žé žåãããªãŠã ãæ°Žé žåã«ãªãŠ
ã ãæ°Žé žåããªãŠã ãªã©ã®å¡©åºæ§ååç©ãç¡«é žã
å¡©é žãç¡é žãªã©ã®é±é žãªã©ã®ååšäžã«è¡ãªãã
ãããã®å æ°Žå解åå¿ã¯äžè¬ã«æº¶åªäžã§æå©ã«é²
è¡ããããã®é䜿çšããã溶åªãšããŠã¯åå¿ã«é¢
äžããªããã¹ãŠã®æº¶åªã䜿çšã§ããäŸãã°ãæ°Žã
ã¡ã¿ããŒã«ããšã¿ããŒã«ãã€ãœãããããŒã«ãªã©
ã®äœçŽã¢ã«ã³ãŒã«é¡ã奜ãŸãããåå¿æž©åºŠãšããŠ
ã¯ãšãã«éå®ããããåºãç¯å²ããé©å®éžæãã
ã°ããããé垞宀枩ã150âçšåºŠã奜ãŸããã¯50
ã110âã§åå¿ãè¡ãªãã®ãããã該åå¿ã¯äžè¬
ã«30åã10æéçšåºŠã§çµäºããã ååç©(2)ã®ãšã¹ãã«åã¯åžžæ³ã«ããäœçŽã¢ã«ã³
ãŒã«ãšåå¿ãããããšã«ããéããããéåžžã觊
åªã®ååšäžã§è¡ãªãããããã®é䜿çšããã觊åª
ãšããŠã¯éåžžã®ãšã¹ãã«ååå¿ã«äœ¿çšãããŠãã
ãã®ãåºã䜿çšããåŸãã代衚çãªãã®ãšããŠ
ã¯ãäŸãã°å¡©é žã¬ã¹ãæ¿ç¡«é žããªã³é žãããªãªã³
é žãäžããåããŠçŽ ãéå¡©çŽ é žãªã©ã®ç¡æ©é žãã
ãªãããé ¢é žãããªãããã¡ã¿ã³ã¹ã«ãã³é žãã
ãã¿ã¬ã³ã¹ã«ãã³é žãâãã·ã«é žããã³ãŒã³ã¹
ã«ãã³é žããšã¿ã³ã¹ã¹ã«ãã³é žãªã©ã®ææ©é žãã
ãªãããã¡ã¿ã³ã¹ã«ãã³é žç¡æ°Žç©ãªã©ã®é žç¡æ°Ž
ç©ãå¡©åããªãã«ãã¢ã»ãã³ãžã¡ãã«ã¢ã»ã¿ãŒã«
ãªã©ãäŸç€ºã§ãããããã«ã«ããªã³äº€ææš¹èãæ¬
çºæã®è§ŠåªãšããŠçšããããšãã§ããããããã®
觊åªã®äœ¿çšéã¯éåžžçšããããç¯å²ã®ãã®ã§ã
ãããšãã«éå®ãããªãã æ¬åå¿ã¯ç¡æº¶åªãããã¯æº¶åªäžã®ãããã§ãé²
è¡ãããçšãããã溶åªãšããŠã¯ãéåžžã®ãšã¹ã
ã«ååå¿ã«äœ¿çšããã溶åªãæå¹ã«äœ¿çšã§ããå ·
äœçã«ã¯ãã³ãŒã³ããã«ãšã³ããã·ã¬ã³ãªã©ã®è³
éŠæçåæ°ŽçŽ é¡ããžã¯ããã¡ã¿ã³ããžã¯ãããšã¿
ã³ãã¯ãããã«ã ãåå¡©åççŽ ãªã©ã®ããã²ã³å
çåæ°ŽçŽ é¡ããžãšãã«ãšãŒãã«ãããã©ãããã
ã©ã³ããžãªããµã³ããšãã¬ã³ã°ãªã³ãŒã«ã¢ãã¡ã
ã«ãšãŒãã«ãªã©ã®ãšãŒãã«é¡ãæãããããåå
ç©(2)ãšäœçŽã¢ã«ã³ãŒã«ãšã®äœ¿çšå²åã¯ãåºãç¯å²
ã«ãããé©å®ã«éžæããã°ããããæ¬çºæã®ç®ç
ç©ã®çæçãè¯å¥œã«ããããã«ãéåžžãç¡æº¶åªã®
å Žåã«ã¯åè ã«å¯ŸãåŸè ã倧éå°çšãããŸã溶åª
ãçšããå Žåã«ã¯åè ã«å¯ŸãåŸè ãçã¢ã«ãïŒå
ã¢ã«ïŒãšãã«å¥œãŸããã¯çã¢ã«ãïŒåïŒçšããã®
ã奜ãŸããããªãããã®ãšã¹ãã«ååå¿ã«ãããŠ
ã¯ãç¡æ°Žå¡©åã«ã«ã·ãŠã ãç¡æ°Žç¡«é žé ãç¡æ°Žç¡«é ž
ã«ã«ã·ãŠã ãäºé žåãªã³ãªã©ã®ä¹Ÿç¥å€ãçšããŠç
ææ°Žãåå¿ç³»ããé€å»ããããšã«ãããããã«ç
æçãå¢å€§ãããããšãå¯èœã§ãããåå¿æž©åºŠã¯
é©å®éžæããã°ããããšãã«éå®ãããªãããé
åžžãçŽâ20ã200âçšåºŠã®ç¯å²ã§è¡ãªãã®ãããã
ãšãã«çŽïŒã150âçšåºŠã§è¡ãªãã®ã奜ãŸããã
ãŸãåå¿æéã¯åæã®çš®é¡ãåå¿æ¡ä»¶ã«ãããã
äžè¬ã«çŽ10åã20æéã§ããã ããã«æ¬çºæã®ãšã¹ãã«ååå¿ã¯ãååç©(2)ã®
ã«ã«ããã·ã®æŽ»æ§åãããèªå°äœãäŸãã°ãã«ã«
ãã³é žãã©ã€ããã«ã«ãã³é žç¡æ°Žç©ãªã©ãçšãã
ããšãã§ãããã«ã«ãã³é žãã©ã€ããçšããå Žå
ã«ã¯ãåè¿°ã®åå¿åŒâïŒã«ç€ºããã«ã«ãã³é žãã©
ã€ãæ³ã®åå¿æ¡ä»¶ãæ¡çšã§ããããŸããã«ã«ãã³
é žç¡æ°Žç©ãçšããå Žåã«ã¯ãéåžžã®è±æ°Žå€ã«ã
ããã«ã«ãã³é žç¡æ°Žç©ãšããŠãããã«åžžæ³ã«ãã
äœçŽã¢ã«ã³ãŒã«ãåå¿ãããã°ããã äžè¬åŒ(1)ã§è¡šããããååç©ã®ãã¡ãé žæ§åºã
æããååç©ã¯è¬ççã«èš±å®¹ãåŸãå¡©åºæ§ååç©
ãšå¡©ã圢æãåŸãããããå¡©åºæ§ååç©ãšããŠ
ã¯ãäŸãã°æ°Žé žåãããªãŠã ãæ°Žé žåã«ãªãŠã ãª
ã©ã®éå±æ°Žé žåç©ããããªãŠã ã¡ãã©ãŒããã«ãª
ãŠã ãšãã©ãŒããªã©ã®ã¢ã«ã«ãªéå±ã¢ã«ã³ã©ãŒã
ãªã©ãæããããããŸãäžè¬åŒ(1)ã§è¡šããããå
åç©ã®ãã¡ãå¡©åºæ§åºãæããååç©ã¯éåžžã®è¬
ççã«èš±å®¹ãåŸãé žãšå®¹æã«å¡©ã圢æãåŸããã
ããé žãšããŠã¯ãäŸãã°ãç¡«é žãç¡é žãå¡©é žãè
åæ°ŽçŽ é žãªã©ã®ç¡æ©é žãé ¢é žãâãã«ãšã³ã¹ã«
ãã³é žããšã¿ã³ã¹ã«ãã³é žãã·ãŠãŠé žããã¬ã€ã³
é žãã³ãã¯é žãå®æ¯éŠé žãªã©ã®ææ©é žãæããã
ãã ããããŠåŸãããæ¬çºæã®ååç©ã¯ãéåžžçšã
ãããŠããåé¢æ段ã«ãã容æã«åé¢ã粟補ãã
ãããããåé¢æ段ãšããŠã¯æ²æ®¿æ³ãæœåºæ³ãå
çµæ¶æ³ãèžçæ³ãã«ã©ã ã¯ãããã°ã©ãã€ãŸãã¯
ãã¬ãã¯ãã€ãèå±€ã¯ãããã°ã©ãã€ãŒãªã©ãäŸ
瀺ã§ããã æ¬çºæååç©ã¯æ朰çå€ãšããŠæçšã§ãããé
åžžãäžè¬çãªå»è¬è£œå€ã®åœ¢æ ã§çšããããã補å€
ã¯é垞䜿çšãããå å¡«å€ãå¢éå€ãçµåå€ãä»æ¹¿
å€ã厩å£å€ãè¡šé¢æŽ»æ§å€ãæ»æ²¢å€ãªã©ã®åžéå€ã
ããã¯è³Šåœ¢å€ãçšããŠèª¿è£œãããããã®å»è¬è£œå€
ãšããŠã¯åçš®ã®åœ¢æ ãæ²»çç®çã«å¿ããŠéžæã§
ãããã®ä»£è¡šçãªãã®ãšããŠé å€ãäžžå€ãæ£å€ã
液å€ãæžæ¿å€ãä¹³å€ãé¡ç²å€ãã«ãã»ã«å€ãå
å€ã泚å°å€ïŒæ¶²å€ãæžæ¿å€çïŒãªã©ãæããã
ããé å€ã®åœ¢æ ã«æ圢ããã«éããŠã¯ãæ äœãšã
ãŠãã®åéã§åŸæ¥å ¬ç¥ã®ãã®ãåºã䜿çšã§ããäŸ
ãã°ä¹³ç³ãçœç³ãå¡©åãããªãŠã ããããŠç³ãå°¿
çŽ ããã³ãã³ãçé žã«ã«ã·ãŠã ãã«ãªãªã³ãçµæ¶
ã»ã«ããŒã¹ãã±ã€é žãªã©ã®è³Šåœ¢å€ãæ°Žããšã¿ããŒ
ã«ããããããŒã«ãåã·ãããããããŠç³æ¶²ãã
ã³ãã³æ¶²ããŒã©ãã³æº¶æ¶²ãã«ã«ããã·ã¡ãã«ã»ã«
ããŒã¹ãã»ã©ãã¯ãã¡ãã«ã»ã«ããŒã¹ããªã³é žã«
ãªãŠã ãããªããã«ãããªãã³ãªã©ã®çµåå€ã也
ç¥ãã³ãã³ãã¢ã«ã®ã³é žãããªãŠã ãã«ã³ãã³
æ«ãã©ããã©ã³æ«ãçé žæ°ŽçŽ ãããªãŠã ãçé žã«
ã«ã·ãŠã ãããªãªãã·ãšãã¬ã³ãœã«ãã¿ã³èèªé ž
ãšã¹ãã«é¡ãã©ãŠãªã«ç¡«é žãããªãŠã ãã¹ãã¢ãª
ã³é žã¢ãã°ãªã»ãªãããã³ãã³ãä¹³ç³ãªã©åŽ©å£
å€ãçœç³ãã¹ãã¢ãªã³ãã«ã«ãªãã¿ãŒãæ°ŽçŽ æ·»å
æ²¹ãªã©ã®åŽ©å£æå¶å€ã第åçŽã¢ã³ã¢ããŠã å¡©åºã
ã©ãŠãªã«ç¡«é žãããªãŠã ãªã©ã®åžåä¿é²å€ãã°ãª
ã»ãªã³ããã³ãã³ãªã©ã®ä¿æ¹¿å€ããã³ãã³ãä¹³
ç³ãã«ãªãªã³ããã³ããã€ããã³ãã€ãç¶ã±ã€é ž
ãªã©ã®åžçå€ã粟補ã¿ã«ã¯ãã¹ãã¢ãªã³é žå¡©ãã
ãŠé žæ«ãããªãšãã¬ã³ã°ãªã³ãŒã«ãªã©ã®æ»æ²¢å€ãª
ã©ãäŸç€ºã§ãããããã«ãé å€ã¯å¿ èŠã«å¿ãéåžž
ã®å€ç®ãæœããé å€ãäŸãã°ç³è¡£é ããŒã©ãã³è¢«
å é ãè žæº¶è¢«é ããã€ã«ã ã³ãŒãã€ã³ã°é ããã
ã¯äºéé ãå€å±€é ãšããããšãã§ãããäžžå€ã®åœ¢
æ ã«æ圢ããã«éããŠã¯ãæ äœãšããŠãã®åéã§
åŸæ¥å ¬ç¥ã®ãã®ãåºã䜿çšã§ããäŸãã°ããããŠ
ç³ãä¹³ç³ããã³ãã³ãã«ã«ãªèã硬åæ€ç©æ²¹ãã«
ãªãªã³ãã¿ã«ã¯ãªã©ã®è³Šåœ¢å€ãã¢ã©ãã¢ãŽã æ«ã
ãã©ã¬ã³ãæ«ããŒã©ãã³ããšã¿ããŒã«ãªã©ã®çµå
å€ãã©ããã©ã³ãã«ã³ãã³ãªã©ã®åŽ©å£å€ãªã©ãäŸ
瀺ã§ãããåå€ã®åœ¢æ ã«æ圢ããã«éããŠã¯ãæ
äœãšããŠåŸæ¥å ¬ç¥ã®ãã®ãåºã䜿çšã§ããäŸãã°
ããªãšãã¬ã³ã°ãªã³ãŒã«ãã«ã«ãªèãé«çŽã¢ã«ã³
ãŒã«ãé«çŽã¢ã«ã³ãŒã«ã®ãšã¹ãã«é¡ããŒã©ãã³ã
ååæã°ãªã»ã©ã€ããªã©ãæããããšãã§ããã
泚å°å€ãšããŠèª¿è£œãããå Žåã«ã¯ã液å€ããã³æž
æ¿å€ã¯æ®ºèããããã€è¡æ¶²ãšç匵ã§ããã®ã奜ãŸ
ãããããã液å€ãä¹³å€ããã³æžæ¿å€ã®åœ¢æ ã«æ
圢ããã®ã«éããŠã¯ãçšéå€ãšããŠãã®åéã«ã
ããŠæ £çšãããŠãããã®ããã¹ãŠäœ¿çšã§ããäŸã
ã°æ°Žããšãã«ã¢ã«ã³ãŒã«ããããã¬ã³ã°ãªã³ãŒ
ã«ããšããã·åã€ãœã¹ãã¢ãªã«ã¢ã«ã³ãŒã«ãããª
ãªãã·åã€ãœã¹ãã¢ãªã«ã¢ã«ã³ãŒã«ãããªãªãã·
ãšãã¬ã³ãœã«ãã¿ã³èèªé žãšã¹ãã«é¡ãªã©ãæã
ãããšãã§ããããªãããã®å Žåç匵æ§ã®æº¶æ¶²ã
調補ããã«å åãªéã®é£å¡©ããããŠç³ãããã¯ã°
ãªã»ãªã³ãæ朰çå€äžã«å«æããããŠãããããŸ
ãéåžžã®æº¶è§£è£å©å€ãç·©è¡å€ãç¡çåå€ãªã©ãã
æŽã«å¿ èŠã«å¿ããŠçè²å€ãä¿åå€ãéŠæã颚å³
å€ãçå³å€ãªã©ãä»ã®å»è¬åã該治çå€äžã«å«æ
ããããŠãããã æ¬çºæã®æ朰çå€äžã«å«æãããã¹ãæ¬çºæã®
ååç©ã®éã¯ãšãã«éå®ãããåºç¯å²ã«éžæãã
ãããéåžžå šçµæç©äžïŒã70ééïŒ ã奜ãŸããã¯
ïŒã50ééïŒ ã§ããã æ¬çºæã®æ朰çå€ã®æäžæ¹æ³ã¯ãšãã«å¶éã¯ãª
ããå皮補å€åœ¢æ ãæ£è ã®å¹Žä»€ãæ§å¥ãã®ä»ã®æ¡
件ãçŸæ£ã®çšåºŠãªã©ã«å¿ããæ¹æ³ã§æäžãããã
äŸãã°é å€ãäžžå€ã液å€ãæžæ¿å€ãä¹³å€ãé¡ç²å€
ããã³ã«ãã»ã«å€ã®å Žåã«ã¯çµå£æäžãããããŸ
ã泚å°å€ã®å Žåã«ã¯åç¬ã§ãããã¯ãããŠç³ãã¢
ããé žãªã©ã®éåžžã®è£æ¶²ãšæ··åããŠéèå æäžã
ããããã«ã¯å¿ èŠã«å¿ããŠåç¬ã§çèå ãç®å ã
ç®äžãããã¯è ¹è å æäžããããåå€ã®å Žåã«ã¯
çŽè žå æäžãããã æ¬çºæã®æ朰çå€ã®æäžéã¯çšæ³ãæ£è ã®å¹Ž
什ãæ§å¥ãã®ä»ã®æ¡ä»¶ãçŸæ£ã®çšåºŠãªã©ã«ããé©
å®éžæãããããéåžžæ¬çºæååç©ã®éã¯ïŒæ¥åœ
ãäœéïŒKgåœã0.6ã50mgãšããã®ãããããŸãã
æäžåäœåœ¢æ äžã«æå¹æåã10ã1000mgå«æãã
ããã®ãããã è¬çè©Šéš äžè¬åŒ(1)ã§è¡šããããååç©ã®è¬ç掻æ§ããè
液åæ³æå¶äœçšãæ€å®ããæãäžè¬åŒãªè©Šéšæ³ã§
ããã·ãšã€ã»ã©ããã®å¹œéçµçŽ®æ³ã«åŸã€ãŠè©Šéšã
ãããã®è©Šéšã«ã¯äœé170ïœã®ååŸã®ãŠã€ã¹ã¿ãŒ
ç³»éæ§ã©ããã䜿çšããã該ã©ããã24æé絶é£
ããã幜éçµçŽ®30ååã«è©Šéšãããã¹ååç©
ïŒ100mgïŒKgïŒãåäºæè žå æäžããçµçŽ®ïŒæéåŸ
ã«è液éãç·é žåºŠããã³ããã·ã³æŽ»æ§ã枬å®ã
ããççé£å¡©æ°ŽæäžçŸ€ãïŒãšããŠæå¶çãïŒ ã§æ±
ããããã®çµæãäžèšç¬¬ïŒè¡šã«ç€ºãã ãªããè¡šäžã«ãããæå¶çïŒïŒ ïŒã®è©äŸ¡ã¯äžèš
ã®ãšããã§ããã ïŒïŒ10ã50ïŒ æªæº ïŒïŒïŒ50ïŒ ä»¥äž äŸè©Šååç© ïŒ ïŒ®âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒ
âã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒ
âã€ã«ïŒããªâããã«ã¢ãã ïŒ ïŒ®âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒ
âã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâ
ã€ã«ïŒããªâããã«ã¢ãã ïŒ ïŒ®âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒïŒ
ïŒâãžã¡ãã«âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒ
âã€ã«ïŒããªâããã«ã¢ãã
ãã³é žèªå°äœ(5)ãšã®çž®ååå¿ã¯ãéåžžãå¡©åºæ§å
åç©ãçž®åå€ãšããŠçšããŠè¡ãªããã該瞮åå€ãš
ããŠã¯åèšåå¿åŒâïŒã§ç€ºãããåå¿ã«ãããŠçš
ãããããã®ãšåãå¡©åºæ§ååç©ãæããããã
該åå¿ã¯ç¡æº¶åªã§ããããã¯æº¶åªã®ååšäžã§ãè¡
ãªããã溶åªãšããŠã¯åå¿ã«æªåœ±é¿ãäžããªãäž
掻æ§ãªãã®ããã¹ãŠçšããããäŸãã°ãã¡ã¿ããŒ
ã«ããšã¿ããŒã«ããããããŒã«ããã¿ããŒã«ããš
ãã¬ã³ã°ãªã³ãŒã«ãªã©ã®ã¢ã«ã³ãŒã«é¡ããžãšãã«
ãšãŒãã«ãããã©ããããã©ã³ããžãªããµã³ãã¢
ãã°ã©ã€ã ããžã°ã©ã€ã ãªã©ã®ãšãŒãã«é¡ãã¢ã»
ãã³ãã¡ãã«ãšãã«ã±ãã³ãªã©ã®ã±ãã³é¡ããã³
ãŒã³ããã«ãšã³ããã·ã¬ã³ãªã©ã®è³éŠæçåæ°ŽçŽ
é¡ãé ¢é žã¡ãã«ãé ¢é žãšãã«ãªã©ã®ãšã¹ãã«é¡ã
ïŒïŒ®âãžã¡ãã«ãã«ã ã¢ããããžã¡ãã«ã¹ã«ã
ããµã€ãããããµã¡ãã«ãªã³é žããªã¢ãããªã©ã®
éãããã³æ§æ¥µæ§æº¶åªãªã©ãæããããããŸã該
åå¿ã¯ãšãŠåãããªãŠã ããšãŠåã«ãªãŠã ãªã©ã®
éå±ãšãŠåç©ã®ååšäžã«è¡ãªãã®ãæå©ã§ããã
äžèšæ¹æ³ã«ãããååç©(4)ã«å¯Ÿããååç©(5)ã®äœ¿
çšå²åã¯ãšãã«éå®ããããåºç¯å²ã®äžããé©å®
ã«éžæãããããåå¿ãç¡æº¶åªäžã«è¡ãªãå Žåã«
ã¯ãåè ã«å¯ŸããŠåŸè ãé垞倧éå°éã溶åªäžã§
è¡ãªãå Žåã«ã¯ãéåžžãåè ã«å¯ŸããŠåŸè ãçã¢
ã«ãïŒåã¢ã«çšåºŠã奜ãŸããã¯çã¢ã«ãïŒåã¢ã«
éã«ãŠçšããã®ãæãŸããããŸãããã®åå¿æž©åºŠ
ããšãã«éå®ãããªãããéåžžãâ30âã200âçš
床ã奜ãŸããã¯ïŒã160âã§è¡ãªããããåå¿æ
éã¯éåžžïŒã30æéçšåºŠã§ããã ããã«ãæ¬çºæååç©ã®ãã¡ãR2ãäœçŽã¢ã«
ã³ãã·åºã瀺ãååç©ïŒ1bïŒãããã³R2ãæ°Žé žåº
ã瀺ãååç©(2)ã¯ãäžèšåå¿åŒâïŒã«ç€ºãããš
ããåååç©ãå æ°Žå解åå¿ãŸãã¯ãšã¹ãã«åå
å¿ã«ä»ããããšã«ããçžäºã«å€æã§ããã ãåŒäžãR1ãããã³ïŒºã¯åèšãšåããR5ã¯
äœçŽã¢ã«ãã«åºã瀺ãã ååç©ïŒ1bïŒã®å æ°Žå解åå¿ã¯åžžæ³ã«ããè¡
ãªãããäŸãã°æ°Žé žåãããªãŠã ãæ°Žé žåã«ãªãŠ
ã ãæ°Žé žåããªãŠã ãªã©ã®å¡©åºæ§ååç©ãç¡«é žã
å¡©é žãç¡é žãªã©ã®é±é žãªã©ã®ååšäžã«è¡ãªãã
ãããã®å æ°Žå解åå¿ã¯äžè¬ã«æº¶åªäžã§æå©ã«é²
è¡ããããã®é䜿çšããã溶åªãšããŠã¯åå¿ã«é¢
äžããªããã¹ãŠã®æº¶åªã䜿çšã§ããäŸãã°ãæ°Žã
ã¡ã¿ããŒã«ããšã¿ããŒã«ãã€ãœãããããŒã«ãªã©
ã®äœçŽã¢ã«ã³ãŒã«é¡ã奜ãŸãããåå¿æž©åºŠãšããŠ
ã¯ãšãã«éå®ããããåºãç¯å²ããé©å®éžæãã
ã°ããããé垞宀枩ã150âçšåºŠã奜ãŸããã¯50
ã110âã§åå¿ãè¡ãªãã®ãããã該åå¿ã¯äžè¬
ã«30åã10æéçšåºŠã§çµäºããã ååç©(2)ã®ãšã¹ãã«åã¯åžžæ³ã«ããäœçŽã¢ã«ã³
ãŒã«ãšåå¿ãããããšã«ããéããããéåžžã觊
åªã®ååšäžã§è¡ãªãããããã®é䜿çšããã觊åª
ãšããŠã¯éåžžã®ãšã¹ãã«ååå¿ã«äœ¿çšãããŠãã
ãã®ãåºã䜿çšããåŸãã代衚çãªãã®ãšããŠ
ã¯ãäŸãã°å¡©é žã¬ã¹ãæ¿ç¡«é žããªã³é žãããªãªã³
é žãäžããåããŠçŽ ãéå¡©çŽ é žãªã©ã®ç¡æ©é žãã
ãªãããé ¢é žãããªãããã¡ã¿ã³ã¹ã«ãã³é žãã
ãã¿ã¬ã³ã¹ã«ãã³é žãâãã·ã«é žããã³ãŒã³ã¹
ã«ãã³é žããšã¿ã³ã¹ã¹ã«ãã³é žãªã©ã®ææ©é žãã
ãªãããã¡ã¿ã³ã¹ã«ãã³é žç¡æ°Žç©ãªã©ã®é žç¡æ°Ž
ç©ãå¡©åããªãã«ãã¢ã»ãã³ãžã¡ãã«ã¢ã»ã¿ãŒã«
ãªã©ãäŸç€ºã§ãããããã«ã«ããªã³äº€ææš¹èãæ¬
çºæã®è§ŠåªãšããŠçšããããšãã§ããããããã®
觊åªã®äœ¿çšéã¯éåžžçšããããç¯å²ã®ãã®ã§ã
ãããšãã«éå®ãããªãã æ¬åå¿ã¯ç¡æº¶åªãããã¯æº¶åªäžã®ãããã§ãé²
è¡ãããçšãããã溶åªãšããŠã¯ãéåžžã®ãšã¹ã
ã«ååå¿ã«äœ¿çšããã溶åªãæå¹ã«äœ¿çšã§ããå ·
äœçã«ã¯ãã³ãŒã³ããã«ãšã³ããã·ã¬ã³ãªã©ã®è³
éŠæçåæ°ŽçŽ é¡ããžã¯ããã¡ã¿ã³ããžã¯ãããšã¿
ã³ãã¯ãããã«ã ãåå¡©åççŽ ãªã©ã®ããã²ã³å
çåæ°ŽçŽ é¡ããžãšãã«ãšãŒãã«ãããã©ãããã
ã©ã³ããžãªããµã³ããšãã¬ã³ã°ãªã³ãŒã«ã¢ãã¡ã
ã«ãšãŒãã«ãªã©ã®ãšãŒãã«é¡ãæãããããåå
ç©(2)ãšäœçŽã¢ã«ã³ãŒã«ãšã®äœ¿çšå²åã¯ãåºãç¯å²
ã«ãããé©å®ã«éžæããã°ããããæ¬çºæã®ç®ç
ç©ã®çæçãè¯å¥œã«ããããã«ãéåžžãç¡æº¶åªã®
å Žåã«ã¯åè ã«å¯ŸãåŸè ã倧éå°çšãããŸã溶åª
ãçšããå Žåã«ã¯åè ã«å¯ŸãåŸè ãçã¢ã«ãïŒå
ã¢ã«ïŒãšãã«å¥œãŸããã¯çã¢ã«ãïŒåïŒçšããã®
ã奜ãŸããããªãããã®ãšã¹ãã«ååå¿ã«ãããŠ
ã¯ãç¡æ°Žå¡©åã«ã«ã·ãŠã ãç¡æ°Žç¡«é žé ãç¡æ°Žç¡«é ž
ã«ã«ã·ãŠã ãäºé žåãªã³ãªã©ã®ä¹Ÿç¥å€ãçšããŠç
ææ°Žãåå¿ç³»ããé€å»ããããšã«ãããããã«ç
æçãå¢å€§ãããããšãå¯èœã§ãããåå¿æž©åºŠã¯
é©å®éžæããã°ããããšãã«éå®ãããªãããé
åžžãçŽâ20ã200âçšåºŠã®ç¯å²ã§è¡ãªãã®ãããã
ãšãã«çŽïŒã150âçšåºŠã§è¡ãªãã®ã奜ãŸããã
ãŸãåå¿æéã¯åæã®çš®é¡ãåå¿æ¡ä»¶ã«ãããã
äžè¬ã«çŽ10åã20æéã§ããã ããã«æ¬çºæã®ãšã¹ãã«ååå¿ã¯ãååç©(2)ã®
ã«ã«ããã·ã®æŽ»æ§åãããèªå°äœãäŸãã°ãã«ã«
ãã³é žãã©ã€ããã«ã«ãã³é žç¡æ°Žç©ãªã©ãçšãã
ããšãã§ãããã«ã«ãã³é žãã©ã€ããçšããå Žå
ã«ã¯ãåè¿°ã®åå¿åŒâïŒã«ç€ºããã«ã«ãã³é žãã©
ã€ãæ³ã®åå¿æ¡ä»¶ãæ¡çšã§ããããŸããã«ã«ãã³
é žç¡æ°Žç©ãçšããå Žåã«ã¯ãéåžžã®è±æ°Žå€ã«ã
ããã«ã«ãã³é žç¡æ°Žç©ãšããŠãããã«åžžæ³ã«ãã
äœçŽã¢ã«ã³ãŒã«ãåå¿ãããã°ããã äžè¬åŒ(1)ã§è¡šããããååç©ã®ãã¡ãé žæ§åºã
æããååç©ã¯è¬ççã«èš±å®¹ãåŸãå¡©åºæ§ååç©
ãšå¡©ã圢æãåŸãããããå¡©åºæ§ååç©ãšããŠ
ã¯ãäŸãã°æ°Žé žåãããªãŠã ãæ°Žé žåã«ãªãŠã ãª
ã©ã®éå±æ°Žé žåç©ããããªãŠã ã¡ãã©ãŒããã«ãª
ãŠã ãšãã©ãŒããªã©ã®ã¢ã«ã«ãªéå±ã¢ã«ã³ã©ãŒã
ãªã©ãæããããããŸãäžè¬åŒ(1)ã§è¡šããããå
åç©ã®ãã¡ãå¡©åºæ§åºãæããååç©ã¯éåžžã®è¬
ççã«èš±å®¹ãåŸãé žãšå®¹æã«å¡©ã圢æãåŸããã
ããé žãšããŠã¯ãäŸãã°ãç¡«é žãç¡é žãå¡©é žãè
åæ°ŽçŽ é žãªã©ã®ç¡æ©é žãé ¢é žãâãã«ãšã³ã¹ã«
ãã³é žããšã¿ã³ã¹ã«ãã³é žãã·ãŠãŠé žããã¬ã€ã³
é žãã³ãã¯é žãå®æ¯éŠé žãªã©ã®ææ©é žãæããã
ãã ããããŠåŸãããæ¬çºæã®ååç©ã¯ãéåžžçšã
ãããŠããåé¢æ段ã«ãã容æã«åé¢ã粟補ãã
ãããããåé¢æ段ãšããŠã¯æ²æ®¿æ³ãæœåºæ³ãå
çµæ¶æ³ãèžçæ³ãã«ã©ã ã¯ãããã°ã©ãã€ãŸãã¯
ãã¬ãã¯ãã€ãèå±€ã¯ãããã°ã©ãã€ãŒãªã©ãäŸ
瀺ã§ããã æ¬çºæååç©ã¯æ朰çå€ãšããŠæçšã§ãããé
åžžãäžè¬çãªå»è¬è£œå€ã®åœ¢æ ã§çšããããã補å€
ã¯é垞䜿çšãããå å¡«å€ãå¢éå€ãçµåå€ãä»æ¹¿
å€ã厩å£å€ãè¡šé¢æŽ»æ§å€ãæ»æ²¢å€ãªã©ã®åžéå€ã
ããã¯è³Šåœ¢å€ãçšããŠèª¿è£œãããããã®å»è¬è£œå€
ãšããŠã¯åçš®ã®åœ¢æ ãæ²»çç®çã«å¿ããŠéžæã§
ãããã®ä»£è¡šçãªãã®ãšããŠé å€ãäžžå€ãæ£å€ã
液å€ãæžæ¿å€ãä¹³å€ãé¡ç²å€ãã«ãã»ã«å€ãå
å€ã泚å°å€ïŒæ¶²å€ãæžæ¿å€çïŒãªã©ãæããã
ããé å€ã®åœ¢æ ã«æ圢ããã«éããŠã¯ãæ äœãšã
ãŠãã®åéã§åŸæ¥å ¬ç¥ã®ãã®ãåºã䜿çšã§ããäŸ
ãã°ä¹³ç³ãçœç³ãå¡©åãããªãŠã ããããŠç³ãå°¿
çŽ ããã³ãã³ãçé žã«ã«ã·ãŠã ãã«ãªãªã³ãçµæ¶
ã»ã«ããŒã¹ãã±ã€é žãªã©ã®è³Šåœ¢å€ãæ°Žããšã¿ããŒ
ã«ããããããŒã«ãåã·ãããããããŠç³æ¶²ãã
ã³ãã³æ¶²ããŒã©ãã³æº¶æ¶²ãã«ã«ããã·ã¡ãã«ã»ã«
ããŒã¹ãã»ã©ãã¯ãã¡ãã«ã»ã«ããŒã¹ããªã³é žã«
ãªãŠã ãããªããã«ãããªãã³ãªã©ã®çµåå€ã也
ç¥ãã³ãã³ãã¢ã«ã®ã³é žãããªãŠã ãã«ã³ãã³
æ«ãã©ããã©ã³æ«ãçé žæ°ŽçŽ ãããªãŠã ãçé žã«
ã«ã·ãŠã ãããªãªãã·ãšãã¬ã³ãœã«ãã¿ã³èèªé ž
ãšã¹ãã«é¡ãã©ãŠãªã«ç¡«é žãããªãŠã ãã¹ãã¢ãª
ã³é žã¢ãã°ãªã»ãªãããã³ãã³ãä¹³ç³ãªã©åŽ©å£
å€ãçœç³ãã¹ãã¢ãªã³ãã«ã«ãªãã¿ãŒãæ°ŽçŽ æ·»å
æ²¹ãªã©ã®åŽ©å£æå¶å€ã第åçŽã¢ã³ã¢ããŠã å¡©åºã
ã©ãŠãªã«ç¡«é žãããªãŠã ãªã©ã®åžåä¿é²å€ãã°ãª
ã»ãªã³ããã³ãã³ãªã©ã®ä¿æ¹¿å€ããã³ãã³ãä¹³
ç³ãã«ãªãªã³ããã³ããã€ããã³ãã€ãç¶ã±ã€é ž
ãªã©ã®åžçå€ã粟補ã¿ã«ã¯ãã¹ãã¢ãªã³é žå¡©ãã
ãŠé žæ«ãããªãšãã¬ã³ã°ãªã³ãŒã«ãªã©ã®æ»æ²¢å€ãª
ã©ãäŸç€ºã§ãããããã«ãé å€ã¯å¿ èŠã«å¿ãéåžž
ã®å€ç®ãæœããé å€ãäŸãã°ç³è¡£é ããŒã©ãã³è¢«
å é ãè žæº¶è¢«é ããã€ã«ã ã³ãŒãã€ã³ã°é ããã
ã¯äºéé ãå€å±€é ãšããããšãã§ãããäžžå€ã®åœ¢
æ ã«æ圢ããã«éããŠã¯ãæ äœãšããŠãã®åéã§
åŸæ¥å ¬ç¥ã®ãã®ãåºã䜿çšã§ããäŸãã°ããããŠ
ç³ãä¹³ç³ããã³ãã³ãã«ã«ãªèã硬åæ€ç©æ²¹ãã«
ãªãªã³ãã¿ã«ã¯ãªã©ã®è³Šåœ¢å€ãã¢ã©ãã¢ãŽã æ«ã
ãã©ã¬ã³ãæ«ããŒã©ãã³ããšã¿ããŒã«ãªã©ã®çµå
å€ãã©ããã©ã³ãã«ã³ãã³ãªã©ã®åŽ©å£å€ãªã©ãäŸ
瀺ã§ãããåå€ã®åœ¢æ ã«æ圢ããã«éããŠã¯ãæ
äœãšããŠåŸæ¥å ¬ç¥ã®ãã®ãåºã䜿çšã§ããäŸãã°
ããªãšãã¬ã³ã°ãªã³ãŒã«ãã«ã«ãªèãé«çŽã¢ã«ã³
ãŒã«ãé«çŽã¢ã«ã³ãŒã«ã®ãšã¹ãã«é¡ããŒã©ãã³ã
ååæã°ãªã»ã©ã€ããªã©ãæããããšãã§ããã
泚å°å€ãšããŠèª¿è£œãããå Žåã«ã¯ã液å€ããã³æž
æ¿å€ã¯æ®ºèããããã€è¡æ¶²ãšç匵ã§ããã®ã奜ãŸ
ãããããã液å€ãä¹³å€ããã³æžæ¿å€ã®åœ¢æ ã«æ
圢ããã®ã«éããŠã¯ãçšéå€ãšããŠãã®åéã«ã
ããŠæ £çšãããŠãããã®ããã¹ãŠäœ¿çšã§ããäŸã
ã°æ°Žããšãã«ã¢ã«ã³ãŒã«ããããã¬ã³ã°ãªã³ãŒ
ã«ããšããã·åã€ãœã¹ãã¢ãªã«ã¢ã«ã³ãŒã«ãããª
ãªãã·åã€ãœã¹ãã¢ãªã«ã¢ã«ã³ãŒã«ãããªãªãã·
ãšãã¬ã³ãœã«ãã¿ã³èèªé žãšã¹ãã«é¡ãªã©ãæã
ãããšãã§ããããªãããã®å Žåç匵æ§ã®æº¶æ¶²ã
調補ããã«å åãªéã®é£å¡©ããããŠç³ãããã¯ã°
ãªã»ãªã³ãæ朰çå€äžã«å«æããããŠãããããŸ
ãéåžžã®æº¶è§£è£å©å€ãç·©è¡å€ãç¡çåå€ãªã©ãã
æŽã«å¿ èŠã«å¿ããŠçè²å€ãä¿åå€ãéŠæã颚å³
å€ãçå³å€ãªã©ãä»ã®å»è¬åã該治çå€äžã«å«æ
ããããŠãããã æ¬çºæã®æ朰çå€äžã«å«æãããã¹ãæ¬çºæã®
ååç©ã®éã¯ãšãã«éå®ãããåºç¯å²ã«éžæãã
ãããéåžžå šçµæç©äžïŒã70ééïŒ ã奜ãŸããã¯
ïŒã50ééïŒ ã§ããã æ¬çºæã®æ朰çå€ã®æäžæ¹æ³ã¯ãšãã«å¶éã¯ãª
ããå皮補å€åœ¢æ ãæ£è ã®å¹Žä»€ãæ§å¥ãã®ä»ã®æ¡
件ãçŸæ£ã®çšåºŠãªã©ã«å¿ããæ¹æ³ã§æäžãããã
äŸãã°é å€ãäžžå€ã液å€ãæžæ¿å€ãä¹³å€ãé¡ç²å€
ããã³ã«ãã»ã«å€ã®å Žåã«ã¯çµå£æäžãããããŸ
ã泚å°å€ã®å Žåã«ã¯åç¬ã§ãããã¯ãããŠç³ãã¢
ããé žãªã©ã®éåžžã®è£æ¶²ãšæ··åããŠéèå æäžã
ããããã«ã¯å¿ èŠã«å¿ããŠåç¬ã§çèå ãç®å ã
ç®äžãããã¯è ¹è å æäžããããåå€ã®å Žåã«ã¯
çŽè žå æäžãããã æ¬çºæã®æ朰çå€ã®æäžéã¯çšæ³ãæ£è ã®å¹Ž
什ãæ§å¥ãã®ä»ã®æ¡ä»¶ãçŸæ£ã®çšåºŠãªã©ã«ããé©
å®éžæãããããéåžžæ¬çºæååç©ã®éã¯ïŒæ¥åœ
ãäœéïŒKgåœã0.6ã50mgãšããã®ãããããŸãã
æäžåäœåœ¢æ äžã«æå¹æåã10ã1000mgå«æãã
ããã®ãããã è¬çè©Šéš äžè¬åŒ(1)ã§è¡šããããååç©ã®è¬ç掻æ§ããè
液åæ³æå¶äœçšãæ€å®ããæãäžè¬åŒãªè©Šéšæ³ã§
ããã·ãšã€ã»ã©ããã®å¹œéçµçŽ®æ³ã«åŸã€ãŠè©Šéšã
ãããã®è©Šéšã«ã¯äœé170ïœã®ååŸã®ãŠã€ã¹ã¿ãŒ
ç³»éæ§ã©ããã䜿çšããã該ã©ããã24æé絶é£
ããã幜éçµçŽ®30ååã«è©Šéšãããã¹ååç©
ïŒ100mgïŒKgïŒãåäºæè žå æäžããçµçŽ®ïŒæéåŸ
ã«è液éãç·é žåºŠããã³ããã·ã³æŽ»æ§ã枬å®ã
ããççé£å¡©æ°ŽæäžçŸ€ãïŒãšããŠæå¶çãïŒ ã§æ±
ããããã®çµæãäžèšç¬¬ïŒè¡šã«ç€ºãã ãªããè¡šäžã«ãããæå¶çïŒïŒ ïŒã®è©äŸ¡ã¯äžèš
ã®ãšããã§ããã ïŒïŒ10ã50ïŒ æªæº ïŒïŒïŒ50ïŒ ä»¥äž äŸè©Šååç© ïŒ ïŒ®âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒ
âã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒ
âã€ã«ïŒããªâããã«ã¢ãã ïŒ ïŒ®âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒ
âã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâ
ã€ã«ïŒããªâããã«ã¢ãã ïŒ ïŒ®âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒïŒ
ïŒâãžã¡ãã«âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒ
âã€ã«ïŒããªâããã«ã¢ãã
ãè¡šã
ã€ãã«å®æœäŸããããŠæ¬çºæã®ååç©ããã³ã
ã®è£œæ³ãå ·äœçã«èª¬æããã å®æœäŸ ïŒ ïŒâã¡ãã«âïŒâã¡ã«ã«ããâïŒïŒïŒïŒïŒâãª
ããµãžã¢ãŸãŒã«1.2ïœãšïŒ®âãšãã«ââã·ã¯ã
ããã·ã«âïŒâã¯ãã«ããã«ã¢ãã2.3ïœãšãã¢
ã»ãã³50mlã«æº¶è§£ãããããã«çé žã«ãªãŠã 1.4
ïœãå ããŠïŒæééæµãè¡ãªããã¢ã»ãã³ãçå»
åŸæ®æž£ã«æ°Žãå ãã¯ãããã«ã ã§æœåºãããã¯ã
ããã«ã 溶液ã飜åé£å¡©æ°Žã§æŽæµããç¡«é žãã°ã
ã·ãŠã ã§ä¹Ÿç¥ãããã¯ãããã«ã ãçå»ããæ®æž£
ãã«ã©ã ã¯ãããã°ã©ãã€ïŒã¡ã«ã¯è£œãããŒãŒã«
ã²ã«60ïŒã§ç²Ÿè£œããããããµã³âãšãŒãã«ïŒïŒïŒ
ïŒïŒã§æº¶åºããŠãç¡è²æ¶²äœã®ïŒ®âãšãã«ââã·
ã¯ãããã·ã«âïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒïŒâ
ãªããµãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâããã«ã¢ã
ã1.3ïœãåŸããn18 DïŒ1.5252 å çŽ åæå€ïŒC15H25N3O2Sãšã㊠èšç®å€ïŒïŒ ïŒïŒïŒ£ïŒ57.85ïŒïŒšïŒ8.09ïŒïŒ®ïŒ13.49 åæå€ïŒïŒ ïŒïŒïŒ£ïŒ57.96ïŒïŒšïŒ8.16ïŒïŒ®ïŒ13.56 å®æœäŸïŒãïŒ å®æœäŸïŒãšåæ§ã«ããŠäžèšååç©ãåŸãã (2)âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒ
âã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâããã«ã¢ãããç¡è²ç²ç¶æ¶ïŒãããµã³
âé ¢é žãšãã«ããåçµæ¶ïŒãèç¹126ã127.5â å çŽ åæå€ïŒC14H24N4OS2ãšã㊠èšç®å€ïŒïŒ ïŒïŒïŒ£ïŒ51.19ïŒïŒšïŒ7.36ïŒïŒ®ïŒ17.06 åæå€ïŒïŒ ïŒïŒïŒ£ïŒ51.18ïŒïŒšïŒ7.38ïŒïŒ®ïŒ17.01 (3)ïŒïŒ®âãžãšãã«âïŒâïŒïŒâã¢ããâïŒïŒ
ïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâãã
ã«ã¢ãããç¡è²éç¶æ¶ïŒé ¢é žãšãã«ïŒãèç¹77.5
ã79â å çŽ åæå€ïŒC10H18N4OS2ãšã㊠èšç®å€ïŒïŒ ïŒïŒïŒ£ïŒ43.77ïŒïŒšïŒ6.61ïŒïŒ®ïŒ20.42 åæå€ïŒïŒ ïŒïŒïŒ£ïŒ43.51ïŒïŒšïŒ6.40ïŒïŒ®ïŒ20.42 (4)âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒïŒ
ïŒâãžã¡ãã«âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâ
ã€ã«ïŒããªâããã«ã¢ãããæ·¡é»è²æ¶²äœãn28.5 DïŒ
1.5299 å çŽ åæå€ïŒC16H28N4OSãšã㊠èšç®å€ïŒïŒ ïŒïŒïŒ£ïŒ59.22ïŒïŒšïŒ8.70ïŒïŒ®ïŒ17.27 åæå€ïŒïŒ ïŒïŒïŒ£ïŒ59.29ïŒïŒšïŒ8.81ïŒïŒ®ïŒ17.38 (5)âã¡ãã«ââã·ã¯ãããã·ã«âïŒâïŒ1H
âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€ã«ïŒããªâ
ããã«ã¢ãããç¡è²æ¶²äœãn18 DïŒ1.5394 å çŽ åæå€ïŒC14H24N4OSãšã㊠èšç®å€ïŒïŒ ïŒïŒïŒ£ïŒ56.73ïŒïŒšïŒ8.16ïŒïŒ®ïŒ18.90 åæå€ïŒïŒ ïŒïŒïŒ£ïŒ56.82ïŒïŒšïŒ8.23ïŒïŒ®ïŒ19.02 (6)ïŒâïŒïŒâã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸ
ãŒã«âïŒâã€ã«ïŒããªâé ªé žã¡ãã«ãšã¹ãã«ãç¡
è²ç²ç¶æ¶ïŒãããµã³âé ¢é žãšãã«ããåçµæ¶ïŒã
èç¹101ã102.5â å çŽ åæå€ïŒC7H11N3O2S2ãšã㊠èšç®å€ïŒïŒ ïŒïŒïŒ£ïŒ36.04ïŒïŒšïŒ4.75ïŒïŒ®ïŒ18.01 åæå€ïŒïŒ ïŒïŒïŒ£ïŒ36.33ïŒïŒšïŒ4.65ïŒïŒ®ïŒ18ïŒ
39 å®æœäŸ ïŒ ïŒâïŒïŒâã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒ
ã«âïŒâã€ã«ïŒããªâé ªé žã¡ãã«ãšã¹ãã«10ïœã
20ïŒ å¡©é ž150mlã«æº¶è§£ãã济枩90âã§ïŒæéæ¹æ
ãè¡ãªããæžå§äžã§ä¹Ÿåºããæ®æž£ã«æ°Žãå ããæ°Ž
é žåãããªãŠã ã§PHïŒãšãããå·åŽåŸãæåºæ¶ã
åãæ°ŽæŽããæ°Žããåçµæ¶ãè¡ãªã€ãŠç¡è²é±ç
ç¶ã®ïŒâïŒïŒâã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸ
ãŒã«âïŒâã€ã«ïŒããªâé ªé žïŒïœãåŸããèç¹
190ã192â å çŽ åæå€ïŒC6H9N3O2S2ãšã㊠èšç®å€ïŒïŒ ïŒïŒïŒ£ïŒ32.87ïŒïŒšïŒ4.14ïŒïŒ®ïŒ19.16 åæå€ïŒïŒ ïŒïŒïŒ£ïŒ33.05ïŒïŒšïŒ4.42ïŒïŒ®ïŒ19.55 å®æœäŸ ïŒ ïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸ
ãŒã«âïŒâã€ã«ïŒããªâé ªé žïŒïœãããã©ããã
ãã©ã³50mlã«æº¶è§£ããããªãšãã«ã¢ãã³1.1ïœã
å ãããããã«æ°·å·æ¹æããªããã¯ãã«ã®é žã€ãœ
ããã«1.5ïœã滎äžãã30åæ¹æãè¡ãªãããã
ã«å®€æž©æ¹æäžãâãšãã«âã·ã¯ãããã·ã«ã¢ã
ã³1.5ïœã滎äžãã宀枩ã§ïŒæéæ¹æãè¡ãªãã
ããã©ããããã©ã³ãçå»åŸãæ®æž£ã«æ°Žãå ãã
ã¯ãããã«ã ã§æœåºãããã¯ãããã«ã 溶液ã飜
åéæ¹æ°Žããã³é£œåé£å¡©æ°Žã§æŽæµããç¡«é žãã°ã
ã·ãŠã ã§ä¹Ÿç¥ãããã¯ãããã«ã ãçå»ããæ®æž£
ãã«ã©ã ã¯ãããã°ã©ãã€ã§ç²Ÿè£œããããããµã³
âãšãŒãã«ïŒïŒïŒïŒïŒã§æº¶åºããŠç¡è²æ¶²äœã®ïŒ®â
ãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâã¡ãã«
âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€ã«ïŒã
ãªâããã«ã¢ãã1.0ïœãåŸããn18 DïŒ1.5252 å çŽ åæå€ïŒC15H25N3O2Sãšã㊠èšç®å€ïŒïŒ ïŒïŒïŒ£ïŒ57.85ïŒïŒšïŒ8.09ïŒïŒ®ïŒ13.49 åæå€ïŒïŒ ïŒïŒïŒ£ïŒ57.96ïŒïŒšïŒ8.16ïŒïŒ®ïŒ13.56 å®æœäŸïŒã12 å®æœäŸïŒãšåæ§ã«ããŠäžèšã®ååç©ãåŸãã (9)âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒ
âã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâããã«ã¢ãããç¡è²ç²ç¶æ¶ïŒãããµã³
âé ¢é žãšãã«ïŒãèç¹126ã127.5â (10)ïŒïŒ®âãžãšãã«âïŒâïŒïŒâã¢ããâïŒïŒ
ïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâãã
ã«ã¢ãããç¡è²éç¶æ¶ïŒé ¢é žãšãã«ïŒãèç¹77.5
ã79â (11)âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒïŒ
ïŒâãžã¡ãã«âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâ
ã€ã«ïŒããªâããã«ã¢ãããæ·¡é»è²æ¶²äœãn28.5 DïŒ
1.5299 (12)âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒ1H
âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€ã«ïŒããªâ
ããã«ã¢ãããç¡è²æ¶²äœãn18 DïŒ1.5394 補å€äŸ ïŒ ïŒ®âãšãã«ââã·ã¯ãããã·ã«âïŒâ ïŒïŒâã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã« âïŒâã€ã«ïŒããªâããã«ã¢ãã 150ïœ ã¢ãã»ã«ïŒåæšåãæåæ(æ ª)è£œïŒ 40ïœ ã³ãŒã³ã¹ã¿ãŒã 30ïœ ã¹ãã¢ãªã³é žãã°ãã·ãŠã ïŒïœ ããããã·ãããã«ã¡ãã«ã»ã«ããŒã¹ 10ïœ ããªãšãã¬ã³ã°ãªã³ãŒã«6000 ïŒïœ ããã·æ²¹ 40ïœ ã¡ã¿ããŒã« 40ïœ æ¬çºæååç©ãã¢ãã»ã«ãã³ãŒã³ã¹ã¿ãŒããã
ã³ã¹ãã¢ãªã³é žãã°ãã·ãŠã ãæ··åç 磚åŸãç³è¡£
R10mmã®ããã§æé ãããåŸãããé å€ãããã
ãã·ãããã«ã¡ãã«ã»ã«ããŒã¹ãããªãšãã¬ã³ã°
ãªã³ãŒã«â6000ãããã·æ²¹ããã³ã¡ã¿ããŒã«ãã
ãããã€ã«ã ã³ãŒãã€ã³ã°å€ã§è¢«èŠãè¡ãªããã€
ã«ã ã³ãŒãã€ã³ã°é ã補é ããã 補å€äŸ ïŒ ïŒâïŒïŒâã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸ ãŒã«âïŒâã€ã«ïŒããªâé ªé žã¡ãã« ãšã¹ãã« 150ïœ ã¯ãšã³é ž 1.0ïœ ã©ã¯ããŒã¹ 33.5ïœ ãªã³é žäºã«ã«ã·ãŠã 70.0ïœ ãã«ãããã¯ïŒŠâ68 30.0ïœ ã©ãŠãªã«ç¡«é žãããªãŠã 15.0ïœ ããªããã«ãããªãã³ 15.0ïœ ããªãšãã¬ã³ã°ãªã³ãŒã« ïŒã«ã«ãã¯ãã¯ã¹1500ïŒ 4.5ïœ ããªãšãã¬ã³ã°ãªã³ãŒã« ïŒã«ã«ãã¯ãã¯ã¹6000ïŒ 45.0ïœ ã³ãŒã³ã¹ã¿ãŒã 30.0ïœ ä¹Ÿç¥ã©ãŠãªã«ç¡«é žãããªãŠã 3.0ïœ ä¹Ÿç¥ã¹ãã¢ãªã³é žãã°ãã·ãŠã 3.0ïœ ãšã¿ããŒã« é©é æ¬çºæååç©ãã¯ãšã³é žãã©ã¯ããŒã¹ããªã³é ž
äºã«ã«ã·ãŠã ããã«ãããã¯ïŒŠâ68ããã³ã©ãŠãª
ã«ç¡«é žãããªãŠã ãæ··åããã äžèšæ··åç©ãNo.60ã¹ã¯ãªãŒã³ã§ãµãããããªã
ãã«ãããªãã³ãã«ã«ãã¯ãã¯ã¹1500ããã³6000
ãå«ãã¢ã«ã³ãŒã«æ§æº¶æ¶²ã§æ¹¿åŒç²ç¶åãããå¿ èŠ
ã«å¿ããŠã¢ã«ã³ãŒã«ãæ·»å ããŠç²æ«ãããŒã¹ãç¶
å¡ã«ãããã³ãŒã³ã¹ã¿ãŒããæ·»å ããåäžãªç²å
ã圢æããããŸã§æ··åãç¶ãããNo.10ã¹ã¯ãªãŒã³
ãééããããã¬ã€ã«å ¥ã100âã®ãªãŒãã³ã§12
ã14æé也ç¥ããã也ç¥ç²åãNo.16ã¹ã¯ãªãŒã³ã§
ãµããã也ç¥ã©ãŠãªã«ç¡«é žãããªãŠã ããã³ä¹Ÿç¥
ã¹ãã¢ãªã³é žãã°ãã·ãŠã ãå ãæ··åããæé æ©
ã§ææã®åœ¢ç¶ã«å§çž®ããã äžèšã®è¯éšãã¯ãã¹ã§åŠçããã¿ã«ã¯ãæ£åžã
湿æ°ã®åžåãé²æ¢ãããè¯éšã®åšå²ã«äžå¡ãå±€ã
被èŠãããå æçšã®ããã«ååãªåæ°ã®ã¯ãã¹è¢«
èŠãè¡ãªããé å€ãå®å šã«äžžããã€æ»ãã«ããã
ãã«ãããã«äžå¡å±€ããã³å¹³æ»è¢«èŠãé©çšãã
ããææã®è²åãåŸããããŸã§çè²è¢«èŠãè¡ãª
ãã也ç¥åŸã被èŠé å€ã磚ããŠåäžãªå æ²¢ã®é å€
ã«ããã 補å€äŸ ïŒ ïŒ®âãšãã«ââã·ã¯ãããã·ã«âïŒâ ïŒïŒïŒïŒâãžã¡ãã«âïŒïŒïŒïŒïŒâããªã¢ãŸ ãŒã«âïŒâã€ã«ïŒããªâããã«ã¢ãã ïŒïœ ããªãšãã¬ã³ã°ãªã³ãŒã« ïŒååéïŒ4000ïŒ 0.3ïœ å¡©åãããªãŠã 0.9ïœ ããªãªãã·ãšãã¬ã³ãœã«ãã¿ã³ ã¢ããªã¬ãŒã 0.4ïœ ã¡ã¿éäºç¡«é žãããªãŠã 0.1ïœ ã¡ãã«âãã©ãã³ 0.18ïœ ãããã«âãã©ãã³ 0.02ïœ æ³šå°çšèžçæ°Ž 100ml äžèšãã©ãã³é¡ãã¡ã¿éäºç¡«é žãããªãŠã ãã
ã³å¡©åãããªãŠã ãæ¹æããªãã80âã§äžèšã®çŽ
åéã®èžçæ°Žã«æº¶è§£ãããåŸããã溶液ã40âãŸ
ã§å·åŽããæ¬çºæååç©ãã€ãã«ããªãšãã¬ã³ã°
ãªã³ãŒã«ããã³ããªãªãã·ãšãã¬ã³ãœã«ãã¿ã³ã¢
ããªã¬ãšãŒãããã®æº¶æ¶²äžã«æº¶è§£ããã次ã«ãã®
溶液ã«æ³šå°çšèžçæ°Žãå ããŠæçµã®å®¹éã«èª¿è£œ
ããé©åœãªãã€ã«ã¿ãŒããŒããŒãçšããŠæ» èé
ããããšã«ããæ» èããŠã泚å°å€ã調補ããã
ã®è£œæ³ãå ·äœçã«èª¬æããã å®æœäŸ ïŒ ïŒâã¡ãã«âïŒâã¡ã«ã«ããâïŒïŒïŒïŒïŒâãª
ããµãžã¢ãŸãŒã«1.2ïœãšïŒ®âãšãã«ââã·ã¯ã
ããã·ã«âïŒâã¯ãã«ããã«ã¢ãã2.3ïœãšãã¢
ã»ãã³50mlã«æº¶è§£ãããããã«çé žã«ãªãŠã 1.4
ïœãå ããŠïŒæééæµãè¡ãªããã¢ã»ãã³ãçå»
åŸæ®æž£ã«æ°Žãå ãã¯ãããã«ã ã§æœåºãããã¯ã
ããã«ã 溶液ã飜åé£å¡©æ°Žã§æŽæµããç¡«é žãã°ã
ã·ãŠã ã§ä¹Ÿç¥ãããã¯ãããã«ã ãçå»ããæ®æž£
ãã«ã©ã ã¯ãããã°ã©ãã€ïŒã¡ã«ã¯è£œãããŒãŒã«
ã²ã«60ïŒã§ç²Ÿè£œããããããµã³âãšãŒãã«ïŒïŒïŒ
ïŒïŒã§æº¶åºããŠãç¡è²æ¶²äœã®ïŒ®âãšãã«ââã·
ã¯ãããã·ã«âïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒïŒâ
ãªããµãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâããã«ã¢ã
ã1.3ïœãåŸããn18 DïŒ1.5252 å çŽ åæå€ïŒC15H25N3O2Sãšã㊠èšç®å€ïŒïŒ ïŒïŒïŒ£ïŒ57.85ïŒïŒšïŒ8.09ïŒïŒ®ïŒ13.49 åæå€ïŒïŒ ïŒïŒïŒ£ïŒ57.96ïŒïŒšïŒ8.16ïŒïŒ®ïŒ13.56 å®æœäŸïŒãïŒ å®æœäŸïŒãšåæ§ã«ããŠäžèšååç©ãåŸãã (2)âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒ
âã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâããã«ã¢ãããç¡è²ç²ç¶æ¶ïŒãããµã³
âé ¢é žãšãã«ããåçµæ¶ïŒãèç¹126ã127.5â å çŽ åæå€ïŒC14H24N4OS2ãšã㊠èšç®å€ïŒïŒ ïŒïŒïŒ£ïŒ51.19ïŒïŒšïŒ7.36ïŒïŒ®ïŒ17.06 åæå€ïŒïŒ ïŒïŒïŒ£ïŒ51.18ïŒïŒšïŒ7.38ïŒïŒ®ïŒ17.01 (3)ïŒïŒ®âãžãšãã«âïŒâïŒïŒâã¢ããâïŒïŒ
ïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâãã
ã«ã¢ãããç¡è²éç¶æ¶ïŒé ¢é žãšãã«ïŒãèç¹77.5
ã79â å çŽ åæå€ïŒC10H18N4OS2ãšã㊠èšç®å€ïŒïŒ ïŒïŒïŒ£ïŒ43.77ïŒïŒšïŒ6.61ïŒïŒ®ïŒ20.42 åæå€ïŒïŒ ïŒïŒïŒ£ïŒ43.51ïŒïŒšïŒ6.40ïŒïŒ®ïŒ20.42 (4)âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒïŒ
ïŒâãžã¡ãã«âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâ
ã€ã«ïŒããªâããã«ã¢ãããæ·¡é»è²æ¶²äœãn28.5 DïŒ
1.5299 å çŽ åæå€ïŒC16H28N4OSãšã㊠èšç®å€ïŒïŒ ïŒïŒïŒ£ïŒ59.22ïŒïŒšïŒ8.70ïŒïŒ®ïŒ17.27 åæå€ïŒïŒ ïŒïŒïŒ£ïŒ59.29ïŒïŒšïŒ8.81ïŒïŒ®ïŒ17.38 (5)âã¡ãã«ââã·ã¯ãããã·ã«âïŒâïŒ1H
âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€ã«ïŒããªâ
ããã«ã¢ãããç¡è²æ¶²äœãn18 DïŒ1.5394 å çŽ åæå€ïŒC14H24N4OSãšã㊠èšç®å€ïŒïŒ ïŒïŒïŒ£ïŒ56.73ïŒïŒšïŒ8.16ïŒïŒ®ïŒ18.90 åæå€ïŒïŒ ïŒïŒïŒ£ïŒ56.82ïŒïŒšïŒ8.23ïŒïŒ®ïŒ19.02 (6)ïŒâïŒïŒâã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸ
ãŒã«âïŒâã€ã«ïŒããªâé ªé žã¡ãã«ãšã¹ãã«ãç¡
è²ç²ç¶æ¶ïŒãããµã³âé ¢é žãšãã«ããåçµæ¶ïŒã
èç¹101ã102.5â å çŽ åæå€ïŒC7H11N3O2S2ãšã㊠èšç®å€ïŒïŒ ïŒïŒïŒ£ïŒ36.04ïŒïŒšïŒ4.75ïŒïŒ®ïŒ18.01 åæå€ïŒïŒ ïŒïŒïŒ£ïŒ36.33ïŒïŒšïŒ4.65ïŒïŒ®ïŒ18ïŒ
39 å®æœäŸ ïŒ ïŒâïŒïŒâã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒ
ã«âïŒâã€ã«ïŒããªâé ªé žã¡ãã«ãšã¹ãã«10ïœã
20ïŒ å¡©é ž150mlã«æº¶è§£ãã济枩90âã§ïŒæéæ¹æ
ãè¡ãªããæžå§äžã§ä¹Ÿåºããæ®æž£ã«æ°Žãå ããæ°Ž
é žåãããªãŠã ã§PHïŒãšãããå·åŽåŸãæåºæ¶ã
åãæ°ŽæŽããæ°Žããåçµæ¶ãè¡ãªã€ãŠç¡è²é±ç
ç¶ã®ïŒâïŒïŒâã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸ
ãŒã«âïŒâã€ã«ïŒããªâé ªé žïŒïœãåŸããèç¹
190ã192â å çŽ åæå€ïŒC6H9N3O2S2ãšã㊠èšç®å€ïŒïŒ ïŒïŒïŒ£ïŒ32.87ïŒïŒšïŒ4.14ïŒïŒ®ïŒ19.16 åæå€ïŒïŒ ïŒïŒïŒ£ïŒ33.05ïŒïŒšïŒ4.42ïŒïŒ®ïŒ19.55 å®æœäŸ ïŒ ïŒâïŒïŒâã¡ãã«âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸ
ãŒã«âïŒâã€ã«ïŒããªâé ªé žïŒïœãããã©ããã
ãã©ã³50mlã«æº¶è§£ããããªãšãã«ã¢ãã³1.1ïœã
å ãããããã«æ°·å·æ¹æããªããã¯ãã«ã®é žã€ãœ
ããã«1.5ïœã滎äžãã30åæ¹æãè¡ãªãããã
ã«å®€æž©æ¹æäžãâãšãã«âã·ã¯ãããã·ã«ã¢ã
ã³1.5ïœã滎äžãã宀枩ã§ïŒæéæ¹æãè¡ãªãã
ããã©ããããã©ã³ãçå»åŸãæ®æž£ã«æ°Žãå ãã
ã¯ãããã«ã ã§æœåºãããã¯ãããã«ã 溶液ã飜
åéæ¹æ°Žããã³é£œåé£å¡©æ°Žã§æŽæµããç¡«é žãã°ã
ã·ãŠã ã§ä¹Ÿç¥ãããã¯ãããã«ã ãçå»ããæ®æž£
ãã«ã©ã ã¯ãããã°ã©ãã€ã§ç²Ÿè£œããããããµã³
âãšãŒãã«ïŒïŒïŒïŒïŒã§æº¶åºããŠç¡è²æ¶²äœã®ïŒ®â
ãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒâã¡ãã«
âïŒïŒïŒïŒïŒâãªããµãžã¢ãŸãŒã«âïŒâã€ã«ïŒã
ãªâããã«ã¢ãã1.0ïœãåŸããn18 DïŒ1.5252 å çŽ åæå€ïŒC15H25N3O2Sãšã㊠èšç®å€ïŒïŒ ïŒïŒïŒ£ïŒ57.85ïŒïŒšïŒ8.09ïŒïŒ®ïŒ13.49 åæå€ïŒïŒ ïŒïŒïŒ£ïŒ57.96ïŒïŒšïŒ8.16ïŒïŒ®ïŒ13.56 å®æœäŸïŒã12 å®æœäŸïŒãšåæ§ã«ããŠäžèšã®ååç©ãåŸãã (9)âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒ
âã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€
ã«ïŒããªâããã«ã¢ãããç¡è²ç²ç¶æ¶ïŒãããµã³
âé ¢é žãšãã«ïŒãèç¹126ã127.5â (10)ïŒïŒ®âãžãšãã«âïŒâïŒïŒâã¢ããâïŒïŒ
ïŒïŒïŒâãã¢ãžã¢ãŸãŒã«âïŒâã€ã«ïŒããªâãã
ã«ã¢ãããç¡è²éç¶æ¶ïŒé ¢é žãšãã«ïŒãèç¹77.5
ã79â (11)âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒïŒïŒ
ïŒâãžã¡ãã«âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâ
ã€ã«ïŒããªâããã«ã¢ãããæ·¡é»è²æ¶²äœãn28.5 DïŒ
1.5299 (12)âãšãã«ââã·ã¯ãããã·ã«âïŒâïŒ1H
âïŒïŒïŒïŒïŒâããªã¢ãŸãŒã«âïŒâã€ã«ïŒããªâ
ããã«ã¢ãããç¡è²æ¶²äœãn18 DïŒ1.5394 補å€äŸ ïŒ ïŒ®âãšãã«ââã·ã¯ãããã·ã«âïŒâ ïŒïŒâã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸãŒã« âïŒâã€ã«ïŒããªâããã«ã¢ãã 150ïœ ã¢ãã»ã«ïŒåæšåãæåæ(æ ª)è£œïŒ 40ïœ ã³ãŒã³ã¹ã¿ãŒã 30ïœ ã¹ãã¢ãªã³é žãã°ãã·ãŠã ïŒïœ ããããã·ãããã«ã¡ãã«ã»ã«ããŒã¹ 10ïœ ããªãšãã¬ã³ã°ãªã³ãŒã«6000 ïŒïœ ããã·æ²¹ 40ïœ ã¡ã¿ããŒã« 40ïœ æ¬çºæååç©ãã¢ãã»ã«ãã³ãŒã³ã¹ã¿ãŒããã
ã³ã¹ãã¢ãªã³é žãã°ãã·ãŠã ãæ··åç 磚åŸãç³è¡£
R10mmã®ããã§æé ãããåŸãããé å€ãããã
ãã·ãããã«ã¡ãã«ã»ã«ããŒã¹ãããªãšãã¬ã³ã°
ãªã³ãŒã«â6000ãããã·æ²¹ããã³ã¡ã¿ããŒã«ãã
ãããã€ã«ã ã³ãŒãã€ã³ã°å€ã§è¢«èŠãè¡ãªããã€
ã«ã ã³ãŒãã€ã³ã°é ã補é ããã 補å€äŸ ïŒ ïŒâïŒïŒâã¢ããâïŒïŒïŒïŒïŒâãã¢ãžã¢ãŸ ãŒã«âïŒâã€ã«ïŒããªâé ªé žã¡ãã« ãšã¹ãã« 150ïœ ã¯ãšã³é ž 1.0ïœ ã©ã¯ããŒã¹ 33.5ïœ ãªã³é žäºã«ã«ã·ãŠã 70.0ïœ ãã«ãããã¯ïŒŠâ68 30.0ïœ ã©ãŠãªã«ç¡«é žãããªãŠã 15.0ïœ ããªããã«ãããªãã³ 15.0ïœ ããªãšãã¬ã³ã°ãªã³ãŒã« ïŒã«ã«ãã¯ãã¯ã¹1500ïŒ 4.5ïœ ããªãšãã¬ã³ã°ãªã³ãŒã« ïŒã«ã«ãã¯ãã¯ã¹6000ïŒ 45.0ïœ ã³ãŒã³ã¹ã¿ãŒã 30.0ïœ ä¹Ÿç¥ã©ãŠãªã«ç¡«é žãããªãŠã 3.0ïœ ä¹Ÿç¥ã¹ãã¢ãªã³é žãã°ãã·ãŠã 3.0ïœ ãšã¿ããŒã« é©é æ¬çºæååç©ãã¯ãšã³é žãã©ã¯ããŒã¹ããªã³é ž
äºã«ã«ã·ãŠã ããã«ãããã¯ïŒŠâ68ããã³ã©ãŠãª
ã«ç¡«é žãããªãŠã ãæ··åããã äžèšæ··åç©ãNo.60ã¹ã¯ãªãŒã³ã§ãµãããããªã
ãã«ãããªãã³ãã«ã«ãã¯ãã¯ã¹1500ããã³6000
ãå«ãã¢ã«ã³ãŒã«æ§æº¶æ¶²ã§æ¹¿åŒç²ç¶åãããå¿ èŠ
ã«å¿ããŠã¢ã«ã³ãŒã«ãæ·»å ããŠç²æ«ãããŒã¹ãç¶
å¡ã«ãããã³ãŒã³ã¹ã¿ãŒããæ·»å ããåäžãªç²å
ã圢æããããŸã§æ··åãç¶ãããNo.10ã¹ã¯ãªãŒã³
ãééããããã¬ã€ã«å ¥ã100âã®ãªãŒãã³ã§12
ã14æé也ç¥ããã也ç¥ç²åãNo.16ã¹ã¯ãªãŒã³ã§
ãµããã也ç¥ã©ãŠãªã«ç¡«é žãããªãŠã ããã³ä¹Ÿç¥
ã¹ãã¢ãªã³é žãã°ãã·ãŠã ãå ãæ··åããæé æ©
ã§ææã®åœ¢ç¶ã«å§çž®ããã äžèšã®è¯éšãã¯ãã¹ã§åŠçããã¿ã«ã¯ãæ£åžã
湿æ°ã®åžåãé²æ¢ãããè¯éšã®åšå²ã«äžå¡ãå±€ã
被èŠãããå æçšã®ããã«ååãªåæ°ã®ã¯ãã¹è¢«
èŠãè¡ãªããé å€ãå®å šã«äžžããã€æ»ãã«ããã
ãã«ãããã«äžå¡å±€ããã³å¹³æ»è¢«èŠãé©çšãã
ããææã®è²åãåŸããããŸã§çè²è¢«èŠãè¡ãª
ãã也ç¥åŸã被èŠé å€ã磚ããŠåäžãªå æ²¢ã®é å€
ã«ããã 補å€äŸ ïŒ ïŒ®âãšãã«ââã·ã¯ãããã·ã«âïŒâ ïŒïŒïŒïŒâãžã¡ãã«âïŒïŒïŒïŒïŒâããªã¢ãŸ ãŒã«âïŒâã€ã«ïŒããªâããã«ã¢ãã ïŒïœ ããªãšãã¬ã³ã°ãªã³ãŒã« ïŒååéïŒ4000ïŒ 0.3ïœ å¡©åãããªãŠã 0.9ïœ ããªãªãã·ãšãã¬ã³ãœã«ãã¿ã³ ã¢ããªã¬ãŒã 0.4ïœ ã¡ã¿éäºç¡«é žãããªãŠã 0.1ïœ ã¡ãã«âãã©ãã³ 0.18ïœ ãããã«âãã©ãã³ 0.02ïœ æ³šå°çšèžçæ°Ž 100ml äžèšãã©ãã³é¡ãã¡ã¿éäºç¡«é žãããªãŠã ãã
ã³å¡©åãããªãŠã ãæ¹æããªãã80âã§äžèšã®çŽ
åéã®èžçæ°Žã«æº¶è§£ãããåŸããã溶液ã40âãŸ
ã§å·åŽããæ¬çºæååç©ãã€ãã«ããªãšãã¬ã³ã°
ãªã³ãŒã«ããã³ããªãªãã·ãšãã¬ã³ãœã«ãã¿ã³ã¢
ããªã¬ãšãŒãããã®æº¶æ¶²äžã«æº¶è§£ããã次ã«ãã®
溶液ã«æ³šå°çšèžçæ°Žãå ããŠæçµã®å®¹éã«èª¿è£œ
ããé©åœãªãã€ã«ã¿ãŒããŒããŒãçšããŠæ» èé
ããããšã«ããæ» èããŠã泚å°å€ã調補ããã
Claims (1)
- ãç¹èš±è«æ±ã®ç¯å²ã ïŒ äžè¬åŒ ãåŒäžãR1ã¯æ°ŽçŽ ååãäœçŽã¢ã«ãã«åºãŸã
ã¯ã¢ããåºãR2ã¯æ°Žé žåºãäœçŽã¢ã«ã³ãã·åºãŸ
ãã¯åºãåŒãã瀺ããR3ããã³R4ã¯åã æ°ŽçŽ ååãäœçŽã¢ã«ãã«åºãŸãã¯ã·ã¯ãã¢ã«ãã«
åºãã¯äœçŽã¢ã«ãã¬ã³åºã瀺ãããŸããã¯é ž
çŽ ååãç¡«é»ååãŸãã¯ïŒ®âR5ã瀺ããR5ã¯
æ°ŽçŽ ååãŸãã¯äœçŽã¢ã«ãã«åºã瀺ãããã ãã
R1ãæ°ŽçŽ ååã瀺ããšãã¯NHã瀺ããR1
ãäœçŽã¢ã«ãã«åºã瀺ããšãã¯ç¡«é»ååã§ãã€
ãŠã¯ãªãããR1ãã¢ããåºã瀺ããšãã¯ç¡«é»
ååã瀺ãã ã§è¡šããããã¢ã«ã«ã³é žèªå°äœããã³ãã®å¡©ã
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55128159A JPS5750973A (en) | 1980-09-16 | 1980-09-16 | Alkane acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55128159A JPS5750973A (en) | 1980-09-16 | 1980-09-16 | Alkane acid derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5750973A JPS5750973A (en) | 1982-03-25 |
JPH0215541B2 true JPH0215541B2 (ja) | 1990-04-12 |
Family
ID=14977838
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP55128159A Granted JPS5750973A (en) | 1980-09-16 | 1980-09-16 | Alkane acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5750973A (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5670526A (en) * | 1995-12-21 | 1997-09-23 | Otsuka Pharmaceutical Co., Ltd. | 1,3,4-oxadiazoles |
-
1980
- 1980-09-16 JP JP55128159A patent/JPS5750973A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS5750973A (en) | 1982-03-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2645962B2 (ja) | ã¢ã³ã®ãªãã³ã·ã³ïœïœæ®æäœçšãæããè€çŽ ç°ååç© | |
WO1995024410A1 (fr) | Derive de diester phosphonique | |
EP0597112A1 (en) | Novel imidazole derivative, pharmaceutical use thereof, and intermediate therefor | |
JPS6338026B2 (ja) | ||
JP3295277B2 (ja) | æè çŸæ£å€åã³ãã³ãºã€ãããŸãŒã«èªå°äœ | |
JPH06135946A (ja) | ãã©ãžã³èªå°äœ | |
JPH04211684A (ja) | ãã³ãŸãã©ã³é¡ | |
JP2002501056A (ja) | ãããªã¯ã¹éå±ãããã€ããŒãŒé»å®³è¬ãšããŠã®ïŒïŒïŒïŒïŒïŒïŒâããã©ãããâïŒïœâïŒïŒïŒïŒœâãã³ãŸãžã¢ãŒãã³âïŒâãããããµã é ž | |
JPH0665664B2 (ja) | ã¢ã«ãã¢ã³ããªãžã³èªå°äœ | |
JPH0215541B2 (ja) | ||
JPH0223546B2 (ja) | ||
JPS6254308B2 (ja) | ||
JPH01132582A (ja) | ããã©ããããã©ã³ã®ïŒïŒïŒâäºçœ®æèªå°äœ | |
JPH0114911B2 (ja) | ||
JPH04297466A (ja) | ããã©ãŸãŒã«èªå°äœåã³å»è¬ | |
JPH0156068B2 (ja) | ||
JP2531962B2 (ja) | ãã³ãŸãããç°èªå°äœ | |
JPS6338988B2 (ja) | ||
JPH07157485A (ja) | çž®åããªããžãã³èªå°äœåã³ããããå«æããã¢ã³ãžãªãã³ã·ã³ïœïœæ®æå€ | |
JPS6328066B2 (ja) | ||
KR840001577B1 (ko) | í ížëŒì¡ž ì ë첎ì ì ì¡°ë°©ë² | |
AU2017348598B2 (en) | Crystalline form of (1R,2R)-2-[4-(3-methyl-1H-pyrazol-5-yl)benzoyl]-N- (4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-3- yl)cyclohexanecarboxamide | |
JPH09136873A (ja) | ã¢ã«ãã«ããªãã¿ã³é žèªå°äœåã³è èçŸæ£çšå€ | |
JPH09301972A (ja) | âïŒïŒâ眮æâã¢ã¶ã·ã¯ãã¢ã«ã«ã³âïŒâã€ã«ïŒã«ã«ãããµããèªå°äœåã³ãããå«æããå»è¬çµæç© | |
JPS62240677A (ja) | ã«ã«ãã¹ããªã«èªå°äœ |