JPH0133120B2 - - Google Patents

Info

Publication number
JPH0133120B2
JPH0133120B2 JP58145419A JP14541983A JPH0133120B2 JP H0133120 B2 JPH0133120 B2 JP H0133120B2 JP 58145419 A JP58145419 A JP 58145419A JP 14541983 A JP14541983 A JP 14541983A JP H0133120 B2 JPH0133120 B2 JP H0133120B2
Authority
JP
Japan
Prior art keywords
residue
neocarzinostatin
formula
ncs
maleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP58145419A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6075499A (ja
Inventor
Hiroshi Maeda
Ryunosuke Kanamaru
Nakao Ishida
Toshihiko Yoshitake
Minoru Ueda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KAYAKU KK
KURARE KK
YAMANOCHI SEIYAKU KK
Original Assignee
KAYAKU KK
KURARE KK
YAMANOCHI SEIYAKU KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KAYAKU KK, KURARE KK, YAMANOCHI SEIYAKU KK filed Critical KAYAKU KK
Priority to JP58145419A priority Critical patent/JPS6075499A/ja
Priority to CA000459768A priority patent/CA1241640A/en
Priority to AT84305414T priority patent/ATE44035T1/de
Priority to EP84305414A priority patent/EP0136792B1/en
Priority to DE8484305414T priority patent/DE3478689D1/de
Publication of JPS6075499A publication Critical patent/JPS6075499A/ja
Priority to US06/911,456 priority patent/US4762885A/en
Publication of JPH0133120B2 publication Critical patent/JPH0133120B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP58145419A 1983-08-08 1983-08-08 ネオカルチノスタチン誘導体及びその製造法 Granted JPS6075499A (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP58145419A JPS6075499A (ja) 1983-08-08 1983-08-08 ネオカルチノスタチン誘導体及びその製造法
CA000459768A CA1241640A (en) 1983-08-08 1984-07-26 Neocarzinostatin derivatives and a process for manufacturing the same
AT84305414T ATE44035T1 (de) 1983-08-08 1984-08-08 Derivate des neocarzinostatins und verfahren zu deren herstellung.
EP84305414A EP0136792B1 (en) 1983-08-08 1984-08-08 Neocarzinostatin derivatives and a process for manufacturing the same
DE8484305414T DE3478689D1 (en) 1983-08-08 1984-08-08 Neocarzinostatin derivatives and a process for manufacturing the same
US06/911,456 US4762885A (en) 1983-08-08 1986-09-25 Neocarzinostatin derivatives and a process for manufacturing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58145419A JPS6075499A (ja) 1983-08-08 1983-08-08 ネオカルチノスタチン誘導体及びその製造法

Publications (2)

Publication Number Publication Date
JPS6075499A JPS6075499A (ja) 1985-04-27
JPH0133120B2 true JPH0133120B2 (enExample) 1989-07-11

Family

ID=15384811

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58145419A Granted JPS6075499A (ja) 1983-08-08 1983-08-08 ネオカルチノスタチン誘導体及びその製造法

Country Status (6)

Country Link
US (1) US4762885A (enExample)
EP (1) EP0136792B1 (enExample)
JP (1) JPS6075499A (enExample)
AT (1) ATE44035T1 (enExample)
CA (1) CA1241640A (enExample)
DE (1) DE3478689D1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2556865B2 (ja) * 1986-09-19 1996-11-27 山之内製薬株式会社 ネオカルチノスタチン誘導体の非注射投与用組成物
US5389366A (en) * 1986-09-19 1995-02-14 Yamanouchi Pharmaceutical Co., Ltd. Neocarzinostatin derivative composition for oral administration
CA1327161C (en) * 1987-09-01 1994-02-22 Mitsugu Kobayashi Lyophilized pharmaceutical composition of neocarzinostatin derivative
US7682630B2 (en) * 2003-05-26 2010-03-23 Hiroshi Maeda Antitumor agent and process for producing the same
WO2006080171A1 (ja) 2005-01-31 2006-08-03 Effector Cell Institute, Inc. 免疫増強剤
CA2933838A1 (en) 2013-11-19 2015-05-28 Hiroshi Maeda Derivative of styrene-maleic acid copolymer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3085994A (en) * 1959-10-30 1963-04-16 Sinclair Research Inc Chain terminated copolymer of styrene and maleic anhydride of low solution viscosity
US3121043A (en) * 1960-05-11 1964-02-11 Scient Associates Inc Sustained release pharmaceutical preparation and methods for making same
US3245933A (en) * 1960-05-19 1966-04-12 Sinclair Research Inc Styrene-maleic anhydride copolymers cross-linked with aliphatic polyhydroxy compounds
JPS6017206B2 (ja) * 1977-03-24 1985-05-01 浩 前田 ネオカルチノスタチン誘導体の製造法
DE3367921D1 (en) * 1982-02-27 1987-01-15 Kuraray Co Neocarzinostatin complexes, a method for producing the same, and an antitumor agent containing said complexes as an active component

Also Published As

Publication number Publication date
EP0136792A2 (en) 1985-04-10
JPS6075499A (ja) 1985-04-27
ATE44035T1 (de) 1989-06-15
CA1241640A (en) 1988-09-06
DE3478689D1 (en) 1989-07-20
EP0136792B1 (en) 1989-06-14
EP0136792A3 (en) 1985-12-18
US4762885A (en) 1988-08-09

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