JPH0132207B2 - - Google Patents
Info
- Publication number
- JPH0132207B2 JPH0132207B2 JP1921982A JP1921982A JPH0132207B2 JP H0132207 B2 JPH0132207 B2 JP H0132207B2 JP 1921982 A JP1921982 A JP 1921982A JP 1921982 A JP1921982 A JP 1921982A JP H0132207 B2 JPH0132207 B2 JP H0132207B2
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- glycyrrhizic acid
- berberine chloride
- poe
- castor oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims description 18
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 16
- VKJGBAJNNALVAV-UHFFFAOYSA-M Berberine chloride (TN) Chemical compound [Cl-].C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 VKJGBAJNNALVAV-UHFFFAOYSA-M 0.000 claims description 15
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 claims description 15
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims description 15
- 229960004949 glycyrrhizic acid Drugs 0.000 claims description 15
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims description 15
- 239000001685 glycyrrhizic acid Substances 0.000 claims description 15
- 235000019410 glycyrrhizin Nutrition 0.000 claims description 15
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 15
- 239000007788 liquid Substances 0.000 claims description 12
- 239000004359 castor oil Substances 0.000 claims description 11
- 235000019438 castor oil Nutrition 0.000 claims description 11
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 11
- 239000002736 nonionic surfactant Substances 0.000 claims description 9
- -1 polyoxyethylene Polymers 0.000 claims description 9
- 150000003611 tocopherol derivatives Chemical class 0.000 claims description 5
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 4
- 229930195729 fatty acid Natural products 0.000 claims description 4
- 239000000194 fatty acid Substances 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 238000003756 stirring Methods 0.000 description 11
- 238000009835 boiling Methods 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 5
- 239000002244 precipitate Substances 0.000 description 5
- 239000008213 purified water Substances 0.000 description 5
- 239000012085 test solution Substances 0.000 description 5
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 4
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 229940042585 tocopherol acetate Drugs 0.000 description 4
- 230000007774 longterm Effects 0.000 description 3
- MSCCTZZBYHQMQJ-AZAGJHQNSA-N Tocopheryl nicotinate Chemical compound C([C@@](OC1=C(C)C=2C)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)CC1=C(C)C=2OC(=O)C1=CC=CN=C1 MSCCTZZBYHQMQJ-AZAGJHQNSA-N 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 229950009883 tocopheryl nicotinate Drugs 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 238000010669 acid-base reaction Methods 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1921982A JPS58140014A (ja) | 1982-02-09 | 1982-02-09 | 透明液状医薬組成物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1921982A JPS58140014A (ja) | 1982-02-09 | 1982-02-09 | 透明液状医薬組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS58140014A JPS58140014A (ja) | 1983-08-19 |
| JPH0132207B2 true JPH0132207B2 (ko) | 1989-06-29 |
Family
ID=11993249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1921982A Granted JPS58140014A (ja) | 1982-02-09 | 1982-02-09 | 透明液状医薬組成物 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS58140014A (ko) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0647536B2 (ja) * | 1985-12-24 | 1994-06-22 | ライオン株式会社 | トコフエロ−ル類含有液剤 |
| JP2536786B2 (ja) * | 1989-05-29 | 1996-09-18 | ゼリア新薬工業株式会社 | 安定な点眼剤 |
| US5939050A (en) * | 1997-04-04 | 1999-08-17 | Optiva Corp. | Antimicrobial compositions |
| US6248309B1 (en) | 1997-04-04 | 2001-06-19 | Optiva Corporation | Gums containing antimicrobial agents |
| JP4753448B2 (ja) * | 1999-08-10 | 2011-08-24 | ライオン株式会社 | パルミチン酸レチノール、レチノールの安定化方法及びビタミン類水溶液 |
| JP2004231600A (ja) * | 2003-01-31 | 2004-08-19 | Takemitsu Ishigaki | 皮膚外用剤 |
| CN106074676B (zh) * | 2016-06-14 | 2019-05-24 | 北京大学 | 一种用于治疗ii型糖尿病及其并发症的药物组合 |
| JP7014078B2 (ja) * | 2018-07-25 | 2022-02-01 | ライオン株式会社 | 眼科用組成物及び析出抑制方法 |
-
1982
- 1982-02-09 JP JP1921982A patent/JPS58140014A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS58140014A (ja) | 1983-08-19 |
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