JPH01213227A - 軟膏剤及び液剤 - Google Patents
軟膏剤及び液剤Info
- Publication number
- JPH01213227A JPH01213227A JP3862388A JP3862388A JPH01213227A JP H01213227 A JPH01213227 A JP H01213227A JP 3862388 A JP3862388 A JP 3862388A JP 3862388 A JP3862388 A JP 3862388A JP H01213227 A JPH01213227 A JP H01213227A
- Authority
- JP
- Japan
- Prior art keywords
- hyaluronic acid
- salt
- ointment
- antihistaminic agent
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002674 ointment Substances 0.000 title claims abstract description 16
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 33
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 32
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 32
- 239000000739 antihistaminic agent Substances 0.000 claims abstract description 27
- 150000003839 salts Chemical class 0.000 claims abstract description 25
- 239000003883 ointment base Substances 0.000 claims abstract description 6
- 239000007788 liquid Substances 0.000 claims description 17
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims description 14
- 230000001387 anti-histamine Effects 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 10
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 208000003251 Pruritus Diseases 0.000 abstract description 12
- 206010048218 Xeroderma Diseases 0.000 abstract description 12
- 206010021198 ichthyosis Diseases 0.000 abstract description 12
- 229940125715 antihistaminic agent Drugs 0.000 abstract description 10
- DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 abstract description 6
- 229940046978 chlorpheniramine maleate Drugs 0.000 abstract description 6
- 239000000203 mixture Substances 0.000 abstract description 5
- 239000004480 active ingredient Substances 0.000 abstract description 4
- 238000002156 mixing Methods 0.000 abstract description 4
- 206010020649 Hyperkeratosis Diseases 0.000 abstract description 3
- 239000004615 ingredient Substances 0.000 abstract description 2
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 208000001126 Keratosis Diseases 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 230000002500 effect on skin Effects 0.000 abstract 1
- 239000003906 humectant Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 9
- 230000007803 itching Effects 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 230000000052 comparative effect Effects 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 159000000000 sodium salts Chemical class 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 5
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000003020 moisturizing effect Effects 0.000 description 4
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 4
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 4
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 4
- 239000008213 purified water Substances 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 3
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 3
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 3
- 206010015150 Erythema Diseases 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 239000004909 Moisturizer Substances 0.000 description 2
- 206010033733 Papule Diseases 0.000 description 2
- 231100000321 erythema Toxicity 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- 230000001333 moisturizer Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- -1 vaseline Chemical compound 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- RZENSCAUEVAXIQ-UHFFFAOYSA-N 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole;sulfuric acid Chemical compound OS(O)(=O)=O.C1=CC(Cl)=CC=C1CN1C2=CC=CC=C2N=C1CN1CCCC1 RZENSCAUEVAXIQ-UHFFFAOYSA-N 0.000 description 1
- SPCKHVPPRJWQRZ-UHFFFAOYSA-N 2-benzhydryloxy-n,n-dimethylethanamine;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 SPCKHVPPRJWQRZ-UHFFFAOYSA-N 0.000 description 1
- CPHGOBGXZQKCKI-UHFFFAOYSA-N 4,5-diphenyl-1h-imidazole Chemical compound N1C=NC(C=2C=CC=CC=2)=C1C1=CC=CC=C1 CPHGOBGXZQKCKI-UHFFFAOYSA-N 0.000 description 1
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- DBAKFASWICGISY-DASCVMRKSA-N Dexchlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C1([C@H](CCN(C)C)C=2N=CC=CC=2)=CC=C(Cl)C=C1 DBAKFASWICGISY-DASCVMRKSA-N 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Chemical group O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- DUKURNFHYQXCJG-UHFFFAOYSA-N Lewis A pentasaccharide Natural products OC1C(O)C(O)C(C)OC1OC1C(OC2C(C(O)C(O)C(CO)O2)O)C(NC(C)=O)C(OC2C(C(OC3C(OC(O)C(O)C3O)CO)OC(CO)C2O)O)OC1CO DUKURNFHYQXCJG-UHFFFAOYSA-N 0.000 description 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 206010039085 Rhinitis allergic Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 201000010105 allergic rhinitis Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- AEMOLEFTQBMNLQ-WAXACMCWSA-N alpha-D-glucuronic acid Chemical group O[C@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-WAXACMCWSA-N 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 229960000520 diphenhydramine Drugs 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 150000002314 glycerols Chemical class 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 208000037852 mild atopic dermatitis Diseases 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 229950006780 n-acetylglucosamine Drugs 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 229940079889 pyrrolidonecarboxylic acid Drugs 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000036620 skin dryness Effects 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3862388A JPH01213227A (ja) | 1988-02-23 | 1988-02-23 | 軟膏剤及び液剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3862388A JPH01213227A (ja) | 1988-02-23 | 1988-02-23 | 軟膏剤及び液剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH01213227A true JPH01213227A (ja) | 1989-08-28 |
| JPH0546323B2 JPH0546323B2 (https=) | 1993-07-13 |
Family
ID=12530366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3862388A Granted JPH01213227A (ja) | 1988-02-23 | 1988-02-23 | 軟膏剤及び液剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH01213227A (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022036987A (ja) * | 2016-01-04 | 2022-03-08 | アヘンシア プブリカ エンプレサリアル サニタリア ホスピタル デ ポニエンテ | 内視鏡的切除術を使用する粘膜病変の治療のために用いられる組成物 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4786630B2 (ja) * | 2007-11-02 | 2011-10-05 | ロート製薬株式会社 | 皮膚外用剤 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61207310A (ja) * | 1985-03-11 | 1986-09-13 | Shiseido Co Ltd | 皮膚外用剤 |
| JPS61236732A (ja) * | 1985-04-05 | 1986-10-22 | フイデイ−ア・ソシエタ・ペル・アチオニ | 新規医薬組成物 |
| JPS6245336A (ja) * | 1985-08-21 | 1987-02-27 | Toyo Biyuut Kk | 乳化組成物 |
| JPS62110722A (ja) * | 1985-11-06 | 1987-05-21 | Nippon Denso Co Ltd | 内燃機関用空気清浄器 |
-
1988
- 1988-02-23 JP JP3862388A patent/JPH01213227A/ja active Granted
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61207310A (ja) * | 1985-03-11 | 1986-09-13 | Shiseido Co Ltd | 皮膚外用剤 |
| JPS61236732A (ja) * | 1985-04-05 | 1986-10-22 | フイデイ−ア・ソシエタ・ペル・アチオニ | 新規医薬組成物 |
| JPS6245336A (ja) * | 1985-08-21 | 1987-02-27 | Toyo Biyuut Kk | 乳化組成物 |
| JPS62110722A (ja) * | 1985-11-06 | 1987-05-21 | Nippon Denso Co Ltd | 内燃機関用空気清浄器 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022036987A (ja) * | 2016-01-04 | 2022-03-08 | アヘンシア プブリカ エンプレサリアル サニタリア ホスピタル デ ポニエンテ | 内視鏡的切除術を使用する粘膜病変の治療のために用いられる組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0546323B2 (https=) | 1993-07-13 |
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