JPH0119366B2 - - Google Patents

Info

Publication number

JPH0119366B2

JPH0119366B2 JP8464682A JP8464682A JPH0119366B2 JP H0119366 B2 JPH0119366 B2 JP H0119366B2 JP 8464682 A JP8464682 A JP 8464682A JP 8464682 A JP8464682 A JP 8464682A JP H0119366 B2 JPH0119366 B2 JP H0119366B2

Authority

JP

Japan

Prior art keywords

target substance

liquid

mixture

pressure

substance

Prior art date

1982-05-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Links

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• 239000013076 target substance Substances 0.000 claims description 47
• 238000002425 crystallisation Methods 0.000 claims description 39
• 230000008025 crystallization Effects 0.000 claims description 34
• 239000007791 liquid phase Substances 0.000 claims description 34
• 239000000203 mixture Substances 0.000 claims description 31
• 239000007788 liquid Substances 0.000 claims description 30
• 239000007790 solid phase Substances 0.000 claims description 30
• 238000000034 method Methods 0.000 claims description 23
• 239000012535 impurity Substances 0.000 claims description 21
• 239000000126 substance Substances 0.000 claims description 11
• RLSSMJSEOOYNOY-UHFFFAOYSA-N m-cresol Chemical compound CC1=CC=CC(O)=C1 RLSSMJSEOOYNOY-UHFFFAOYSA-N 0.000 claims description 10
• IWDCLRJOBJJRNH-UHFFFAOYSA-N p-cresol Chemical compound CC1=CC=C(O)C=C1 IWDCLRJOBJJRNH-UHFFFAOYSA-N 0.000 claims description 10
• 239000007787 solid Substances 0.000 claims description 10
• 230000007423 decrease Effects 0.000 claims description 8
• 230000005496 eutectics Effects 0.000 claims description 8
• 238000002844 melting Methods 0.000 claims description 8
• 230000008018 melting Effects 0.000 claims description 8
• 239000013078 crystal Substances 0.000 claims description 6
• 238000007599 discharging Methods 0.000 claims description 6
• 238000000746 purification Methods 0.000 claims description 6
• 239000000155 melt Substances 0.000 claims description 5
• 230000003247 decreasing effect Effects 0.000 claims description 2
• 239000012071 phase Substances 0.000 claims description 2
• 238000007670 refining Methods 0.000 claims description 2
• 238000011084 recovery Methods 0.000 description 16
• 239000002002 slurry Substances 0.000 description 11
• 230000008859 change Effects 0.000 description 6
• 238000001816 cooling Methods 0.000 description 5
• 230000000052 comparative effect Effects 0.000 description 4
• 238000010586 diagram Methods 0.000 description 4
• 238000002474 experimental method Methods 0.000 description 4
• 238000004062 sedimentation Methods 0.000 description 4
• 239000011550 stock solution Substances 0.000 description 4
• 230000008569 process Effects 0.000 description 3
• 230000000694 effects Effects 0.000 description 2
• 230000005484 gravity Effects 0.000 description 2
• 238000010438 heat treatment Methods 0.000 description 2
• 239000000047 product Substances 0.000 description 2
• 239000002994 raw material Substances 0.000 description 2
• 239000011343 solid material Substances 0.000 description 2
• 239000006228 supernatant Substances 0.000 description 2
• OMOVVBIIQSXZSZ-UHFFFAOYSA-N [6-(4-acetyloxy-5,9a-dimethyl-2,7-dioxo-4,5a,6,9-tetrahydro-3h-pyrano[3,4-b]oxepin-5-yl)-5-formyloxy-3-(furan-3-yl)-3a-methyl-7-methylidene-1a,2,3,4,5,6-hexahydroindeno[1,7a-b]oxiren-4-yl] 2-hydroxy-3-methylpentanoate Chemical compound CC12C(OC(=O)C(O)C(C)CC)C(OC=O)C(C3(C)C(CC(=O)OC4(C)COC(=O)CC43)OC(C)=O)C(=C)C32OC3CC1C=1C=COC=1 OMOVVBIIQSXZSZ-UHFFFAOYSA-N 0.000 description 1
• 238000013459 approach Methods 0.000 description 1
• 150000001875 compounds Chemical class 0.000 description 1
• 239000012141 concentrate Substances 0.000 description 1
• 230000008094 contradictory effect Effects 0.000 description 1
• 238000005265 energy consumption Methods 0.000 description 1
• 238000001125 extrusion Methods 0.000 description 1
• 239000012467 final product Substances 0.000 description 1
• 238000002347 injection Methods 0.000 description 1
• 239000007924 injection Substances 0.000 description 1
• 230000007246 mechanism Effects 0.000 description 1
• NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 description 1
• 230000001376 precipitating effect Effects 0.000 description 1
• 238000001556 precipitation Methods 0.000 description 1
• 238000003825 pressing Methods 0.000 description 1
• 239000012265 solid product Substances 0.000 description 1
• 239000000243 solution Substances 0.000 description 1
• 238000003756 stirring Methods 0.000 description 1
• ADNPLDHMAVUMIW-CUZNLEPHSA-N substance P Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 ADNPLDHMAVUMIW-CUZNLEPHSA-N 0.000 description 1
• 238000011282 treatment Methods 0.000 description 1