JPH01164372A - 溶血抑制剤およびこれを配合してなる医療用具 - Google Patents
溶血抑制剤およびこれを配合してなる医療用具Info
- Publication number
- JPH01164372A JPH01164372A JP62321344A JP32134487A JPH01164372A JP H01164372 A JPH01164372 A JP H01164372A JP 62321344 A JP62321344 A JP 62321344A JP 32134487 A JP32134487 A JP 32134487A JP H01164372 A JPH01164372 A JP H01164372A
- Authority
- JP
- Japan
- Prior art keywords
- blood
- medical device
- plasticizer
- acid ester
- citric acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010018910 Haemolysis Diseases 0.000 title claims abstract description 19
- 230000008588 hemolysis Effects 0.000 title claims abstract description 19
- 239000003112 inhibitor Substances 0.000 title claims abstract description 9
- 238000013329 compounding Methods 0.000 title 1
- 210000004369 blood Anatomy 0.000 claims abstract description 35
- 239000008280 blood Substances 0.000 claims abstract description 35
- 239000004014 plasticizer Substances 0.000 claims abstract description 18
- 239000011347 resin Substances 0.000 claims abstract description 13
- 229920005989 resin Polymers 0.000 claims abstract description 13
- 239000012503 blood component Substances 0.000 claims abstract description 5
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Natural products OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 36
- -1 citric acid ester Chemical class 0.000 claims description 21
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 claims description 8
- PGIBJVOPLXHHGS-UHFFFAOYSA-N Di-n-decyl phthalate Chemical group CCCCCCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCCCCC PGIBJVOPLXHHGS-UHFFFAOYSA-N 0.000 claims description 3
- ARCGXLSVLAOJQL-UHFFFAOYSA-N anhydrous trimellitic acid Natural products OC(=O)C1=CC=C(C(O)=O)C(C(O)=O)=C1 ARCGXLSVLAOJQL-UHFFFAOYSA-N 0.000 claims description 3
- PUFGCEQWYLJYNJ-UHFFFAOYSA-N didodecyl benzene-1,2-dicarboxylate Chemical compound CCCCCCCCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCCCCCCC PUFGCEQWYLJYNJ-UHFFFAOYSA-N 0.000 claims description 3
- BSXJTDJJVULBTQ-UHFFFAOYSA-N 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-heptadecafluorononan-1-ol Chemical compound OCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F BSXJTDJJVULBTQ-UHFFFAOYSA-N 0.000 claims description 2
- 239000004804 Butyryltrihexylcitrate Substances 0.000 claims description 2
- TUUQISRYLMFKOG-UHFFFAOYSA-N trihexyl 2-acetyloxypropane-1,2,3-tricarboxylate Chemical group CCCCCCOC(=O)CC(C(=O)OCCCCCC)(OC(C)=O)CC(=O)OCCCCCC TUUQISRYLMFKOG-UHFFFAOYSA-N 0.000 claims description 2
- 210000003743 erythrocyte Anatomy 0.000 abstract description 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract description 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract description 2
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract description 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract description 2
- 239000001257 hydrogen Substances 0.000 abstract description 2
- 238000000465 moulding Methods 0.000 abstract description 2
- 150000002148 esters Chemical class 0.000 abstract 4
- DQJTUDHTMJVQTF-UHFFFAOYSA-N 2-(1-hexoxy-1,3-dioxobutan-2-yl)-2-hydroxybutanedioic acid Chemical group CCCCCCOC(=O)C(C(C)=O)C(O)(C(O)=O)CC(O)=O DQJTUDHTMJVQTF-UHFFFAOYSA-N 0.000 abstract 1
- GWVUTNGDMGTPFE-UHFFFAOYSA-N trihexyl 2-butanoyloxypropane-1,2,3-tricarboxylate Chemical compound CCCCCCOC(=O)CC(C(=O)OCCCCCC)(OC(=O)CCC)CC(=O)OCCCCCC GWVUTNGDMGTPFE-UHFFFAOYSA-N 0.000 abstract 1
- BJQHLKABXJIVAM-UHFFFAOYSA-N Diethylhexyl phthalate Natural products CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC BJQHLKABXJIVAM-UHFFFAOYSA-N 0.000 description 17
- 239000004803 Di-2ethylhexylphthalate Substances 0.000 description 16
- 239000000203 mixture Substances 0.000 description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 230000035699 permeability Effects 0.000 description 4
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 4
- 239000000463 material Substances 0.000 description 3
- 210000002381 plasma Anatomy 0.000 description 3
- 102000001554 Hemoglobins Human genes 0.000 description 2
- 108010054147 Hemoglobins Proteins 0.000 description 2
- KRADHMIOFJQKEZ-UHFFFAOYSA-N Tri-2-ethylhexyl trimellitate Chemical compound CCCCC(CC)COC(=O)C1=CC=C(C(=O)OCC(CC)CCCC)C(C(=O)OCC(CC)CCCC)=C1 KRADHMIOFJQKEZ-UHFFFAOYSA-N 0.000 description 2
- 125000005907 alkyl ester group Chemical group 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 125000005590 trimellitic acid group Chemical class 0.000 description 2
- BJQHLKABXJIVAM-BGYRXZFFSA-N 1-o-[(2r)-2-ethylhexyl] 2-o-[(2s)-2-ethylhexyl] benzene-1,2-dicarboxylate Chemical compound CCCC[C@H](CC)COC(=O)C1=CC=CC=C1C(=O)OC[C@H](CC)CCCC BJQHLKABXJIVAM-BGYRXZFFSA-N 0.000 description 1
- 239000004808 2-ethylhexylester Substances 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- MQIUGAXCHLFZKX-UHFFFAOYSA-N Di-n-octyl phthalate Chemical compound CCCCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCCC MQIUGAXCHLFZKX-UHFFFAOYSA-N 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- DROMNWUQASBTFM-UHFFFAOYSA-N dinonyl benzene-1,2-dicarboxylate Chemical compound CCCCCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCCCC DROMNWUQASBTFM-UHFFFAOYSA-N 0.000 description 1
- DISZQMPRUTYNJL-UHFFFAOYSA-N ditetradecyl benzene-1,2-dicarboxylate Chemical compound CCCCCCCCCCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCCCCCCCCC DISZQMPRUTYNJL-UHFFFAOYSA-N 0.000 description 1
- QQVHEQUEHCEAKS-UHFFFAOYSA-N diundecyl benzene-1,2-dicarboxylate Chemical compound CCCCCCCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCCCCCC QQVHEQUEHCEAKS-UHFFFAOYSA-N 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
- 210000004623 platelet-rich plasma Anatomy 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000003761 preservation solution Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000002889 tridecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Landscapes
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Materials For Medical Uses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62321344A JPH01164372A (ja) | 1987-12-21 | 1987-12-21 | 溶血抑制剤およびこれを配合してなる医療用具 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62321344A JPH01164372A (ja) | 1987-12-21 | 1987-12-21 | 溶血抑制剤およびこれを配合してなる医療用具 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH01164372A true JPH01164372A (ja) | 1989-06-28 |
| JPH038778B2 JPH038778B2 (no) | 1991-02-06 |
Family
ID=18131534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62321344A Granted JPH01164372A (ja) | 1987-12-21 | 1987-12-21 | 溶血抑制剤およびこれを配合してなる医療用具 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH01164372A (no) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0422363A (ja) * | 1990-05-17 | 1992-01-27 | Nissho Corp | 血小板保存用バッグおよびそれを用いた複合バッグ |
| JPH05501157A (ja) * | 1989-10-13 | 1993-03-04 | トラステイーズ・オブ・ボストン・ユニバーシテイ | 付着性タンパク質に対するリガンド／抗リガンドアッセイ法 |
| JPH07323073A (ja) * | 1994-05-31 | 1995-12-12 | Terumo Corp | 血小板バッグおよびバッグ連結体 |
| JPH08117316A (ja) * | 1994-10-25 | 1996-05-14 | Nippon Sekijiyuujishiya | 血液成分保存容器および容器連結体 |
| JPH09215727A (ja) * | 1995-12-04 | 1997-08-19 | Jms Co Ltd | 医療用容器 |
| JPH10176089A (ja) * | 1996-12-17 | 1998-06-30 | Jms Co Ltd | 医療用容器 |
| JP2006239026A (ja) * | 2005-03-01 | 2006-09-14 | Terumo Corp | ポリ塩化ビニル樹脂製医療用具 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60259264A (ja) * | 1984-06-07 | 1985-12-21 | テルモ株式会社 | 医療用具 |
-
1987
- 1987-12-21 JP JP62321344A patent/JPH01164372A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60259264A (ja) * | 1984-06-07 | 1985-12-21 | テルモ株式会社 | 医療用具 |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05501157A (ja) * | 1989-10-13 | 1993-03-04 | トラステイーズ・オブ・ボストン・ユニバーシテイ | 付着性タンパク質に対するリガンド／抗リガンドアッセイ法 |
| JPH0422363A (ja) * | 1990-05-17 | 1992-01-27 | Nissho Corp | 血小板保存用バッグおよびそれを用いた複合バッグ |
| JPH07323073A (ja) * | 1994-05-31 | 1995-12-12 | Terumo Corp | 血小板バッグおよびバッグ連結体 |
| JPH08117316A (ja) * | 1994-10-25 | 1996-05-14 | Nippon Sekijiyuujishiya | 血液成分保存容器および容器連結体 |
| JPH09215727A (ja) * | 1995-12-04 | 1997-08-19 | Jms Co Ltd | 医療用容器 |
| JPH10176089A (ja) * | 1996-12-17 | 1998-06-30 | Jms Co Ltd | 医療用容器 |
| JP2006239026A (ja) * | 2005-03-01 | 2006-09-14 | Terumo Corp | ポリ塩化ビニル樹脂製医療用具 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH038778B2 (no) | 1991-02-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EXPY | Cancellation because of completion of term |