JP7862413B2 - 四環系オキサゼピン化合物及びその使用 - Google Patents

四環系オキサゼピン化合物及びその使用

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Publication number
JP7862413B2
JP7862413B2 JP2023547523A JP2023547523A JP7862413B2 JP 7862413 B2 JP7862413 B2 JP 7862413B2 JP 2023547523 A JP2023547523 A JP 2023547523A JP 2023547523 A JP2023547523 A JP 2023547523A JP 7862413 B2 JP7862413 B2 JP 7862413B2
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unsubstituted
substituted
pharmaceutically acceptable
alkyl
cancer
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JP2023547523A
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English (en)
Japanese (ja)
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JP2024506029A5 (enExample
JP2024506029A (ja
Inventor
スティーヴン ドー，
ルイス ジェー． ガザード，
サマンサ アリソン グリーン，
マシュー レオ ランドリー，
スシャント マルホトラ，
マイケル シウ，
リーミン チョン，
ユン－シン チョン，
ミンタオ ホー，
チエンフォン シン，
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Genentech Inc
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Genentech Inc
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Publication of JP2024506029A5 publication Critical patent/JP2024506029A5/ja
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2023547523A 2021-02-09 2022-02-07 四環系オキサゼピン化合物及びその使用 Active JP7862413B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN2021076369 2021-02-09
CNPCT/CN2021/076369 2021-02-09
CN2022074435 2022-01-27
CNPCT/CN2022/074435 2022-01-27
PCT/US2022/015407 WO2022173678A1 (en) 2021-02-09 2022-02-07 Tetracyclic oxazepine compounds and uses thereof

Publications (3)

Publication Number Publication Date
JP2024506029A JP2024506029A (ja) 2024-02-08
JP2024506029A5 JP2024506029A5 (enExample) 2025-02-14
JP7862413B2 true JP7862413B2 (ja) 2026-05-19

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023547523A Active JP7862413B2 (ja) 2021-02-09 2022-02-07 四環系オキサゼピン化合物及びその使用

Country Status (11)

Country Link
US (2) US20220281893A1 (enExample)
EP (1) EP4291563A1 (enExample)
JP (1) JP7862413B2 (enExample)
KR (1) KR20230145078A (enExample)
CN (1) CN116867792A (enExample)
AU (1) AU2022218927A1 (enExample)
CA (1) CA3210167A1 (enExample)
IL (1) IL304700A (enExample)
MX (1) MX2023009135A (enExample)
TW (1) TWI824405B (enExample)
WO (1) WO2022173678A1 (enExample)

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TW202440594A (zh) * 2022-12-07 2024-10-16 大陸商北京加科思新藥研發有限公司 稠環化合物及其用途
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AU2022218927A1 (en) 2023-08-03
US20250042919A1 (en) 2025-02-06
IL304700A (en) 2023-09-01
MX2023009135A (es) 2023-08-16
TW202241912A (zh) 2022-11-01
TWI824405B (zh) 2023-12-01
AU2022218927A9 (en) 2024-09-19
WO2022173678A1 (en) 2022-08-18
CA3210167A1 (en) 2022-08-18
US20220281893A1 (en) 2022-09-08
KR20230145078A (ko) 2023-10-17
JP2024506029A (ja) 2024-02-08
CN116867792A (zh) 2023-10-10
EP4291563A1 (en) 2023-12-20

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