JP7854941B2 - 細胞分類指標回路およびその使用の方法 - Google Patents
細胞分類指標回路およびその使用の方法Info
- Publication number
- JP7854941B2 JP7854941B2 JP2022562636A JP2022562636A JP7854941B2 JP 7854941 B2 JP7854941 B2 JP 7854941B2 JP 2022562636 A JP2022562636 A JP 2022562636A JP 2022562636 A JP2022562636 A JP 2022562636A JP 7854941 B2 JP7854941 B2 JP 7854941B2
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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- C12N2330/00—Production
- C12N2330/10—Production naturally occurring
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- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/20—Vector systems having a special element relevant for transcription transcription of more than one cistron
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063009736P | 2020-04-14 | 2020-04-14 | |
| US63/009,736 | 2020-04-14 | ||
| PCT/IB2021/000246 WO2021209813A2 (en) | 2020-04-14 | 2021-04-14 | Cell classifier circuits and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023522025A JP2023522025A (ja) | 2023-05-26 |
| JP2023522025A5 JP2023522025A5 (enExample) | 2024-04-25 |
| JP7854941B2 true JP7854941B2 (ja) | 2026-05-07 |
Family
ID=75919340
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022562636A Active JP7854941B2 (ja) | 2020-04-14 | 2021-04-14 | 細胞分類指標回路およびその使用の方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20230133209A1 (enExample) |
| EP (1) | EP4136241A2 (enExample) |
| JP (1) | JP7854941B2 (enExample) |
| KR (1) | KR20230002611A (enExample) |
| CN (1) | CN115702247A (enExample) |
| AU (1) | AU2021256845A1 (enExample) |
| CA (1) | CA3179339A1 (enExample) |
| WO (1) | WO2021209813A2 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021207526A1 (en) | 2020-04-09 | 2021-10-14 | The Regents Of The University Of California | Humanized notch receptors with hinge domain |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080220471A1 (en) | 2005-07-27 | 2008-09-11 | Genentech, Inc. | Vectors and Methods Using Same |
| CN102716498A (zh) | 2012-03-12 | 2012-10-10 | 中山大学肿瘤防治中心 | 一种可高效高特异灭杀p53基因突变型乳腺癌细胞的药物脂质体 |
| JP2015503354A (ja) | 2012-01-04 | 2015-02-02 | レイセオン ビービーエヌ テクノロジーズ コーポレイション | 調節分子−遺伝子エレメント対により提示される遺伝子発現レベルを評価する方法 |
| CN105274059A (zh) | 2015-06-15 | 2016-01-27 | 中山大学肿瘤防治中心 | 两株可稳定传代并保持原特性的乳腺癌干细胞系及其分离方法和应用 |
| US20170145426A1 (en) | 2014-04-30 | 2017-05-25 | Tsinghua University | Modular construction of synthetic gene circuits in mammalian cells using tale transcriptional repressors |
| JP2019508063A (ja) | 2016-01-27 | 2019-03-28 | オンコラス, インコーポレイテッド | 腫瘍溶解性ウイルスベクター及びその使用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6287813B1 (en) * | 1999-04-23 | 2001-09-11 | Cistronics Cell Technology Gmbh | Antibiotic-based gene regulation system |
| KR101016561B1 (ko) * | 2002-02-19 | 2011-02-22 | 다우 아그로사이언시즈 엘엘씨 | 신규한 스피노신 생산 폴리케타이드 신타제 |
| CA2726052A1 (en) * | 2008-06-04 | 2009-12-10 | The Board Of Regents Of The University Of Texas System | Modulation of gene expression through endogenous small rna targeting of gene promoters |
| WO2016095934A2 (en) * | 2014-12-14 | 2016-06-23 | El Abd Hisham Mohamed Magdy | A novel genetic device to engineer cell behavior |
| JP2022513347A (ja) * | 2018-10-11 | 2022-02-07 | アイドゲノーシッシェ テヒニッシェ ホッホシューレ チューリッヒ | 高度にコンパクトな多入力論理ゲートをコードする核酸ベクターを使用して疾患を処置する方法 |
-
2021
- 2021-04-14 AU AU2021256845A patent/AU2021256845A1/en active Pending
- 2021-04-14 WO PCT/IB2021/000246 patent/WO2021209813A2/en not_active Ceased
- 2021-04-14 KR KR1020227039223A patent/KR20230002611A/ko active Pending
- 2021-04-14 EP EP21725810.2A patent/EP4136241A2/en active Pending
- 2021-04-14 CN CN202180040866.3A patent/CN115702247A/zh active Pending
- 2021-04-14 US US17/918,147 patent/US20230133209A1/en active Pending
- 2021-04-14 JP JP2022562636A patent/JP7854941B2/ja active Active
- 2021-04-14 CA CA3179339A patent/CA3179339A1/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080220471A1 (en) | 2005-07-27 | 2008-09-11 | Genentech, Inc. | Vectors and Methods Using Same |
| JP2015503354A (ja) | 2012-01-04 | 2015-02-02 | レイセオン ビービーエヌ テクノロジーズ コーポレイション | 調節分子−遺伝子エレメント対により提示される遺伝子発現レベルを評価する方法 |
| CN102716498A (zh) | 2012-03-12 | 2012-10-10 | 中山大学肿瘤防治中心 | 一种可高效高特异灭杀p53基因突变型乳腺癌细胞的药物脂质体 |
| US20170145426A1 (en) | 2014-04-30 | 2017-05-25 | Tsinghua University | Modular construction of synthetic gene circuits in mammalian cells using tale transcriptional repressors |
| CN105274059A (zh) | 2015-06-15 | 2016-01-27 | 中山大学肿瘤防治中心 | 两株可稳定传代并保持原特性的乳腺癌干细胞系及其分离方法和应用 |
| JP2019508063A (ja) | 2016-01-27 | 2019-03-28 | オンコラス, インコーポレイテッド | 腫瘍溶解性ウイルスベクター及びその使用 |
Non-Patent Citations (1)
| Title |
|---|
| HAEFLIGER B. et al.,Precision multidimentional assay for high-throughput microRNA drug discovery,Nature Communications,2016年,7: 10709 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20230002611A (ko) | 2023-01-05 |
| CA3179339A1 (en) | 2021-10-21 |
| EP4136241A2 (en) | 2023-02-22 |
| CN115702247A (zh) | 2023-02-14 |
| WO2021209813A3 (en) | 2021-12-30 |
| WO2021209813A2 (en) | 2021-10-21 |
| US20230133209A1 (en) | 2023-05-04 |
| JP2023522025A (ja) | 2023-05-26 |
| AU2021256845A1 (en) | 2022-11-24 |
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