JP7851562B2 - ステロイドのヒドロキシ化方法 - Google Patents

ステロイドのヒドロキシ化方法

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Publication number
JP7851562B2
JP7851562B2 JP2022552804A JP2022552804A JP7851562B2 JP 7851562 B2 JP7851562 B2 JP 7851562B2 JP 2022552804 A JP2022552804 A JP 2022552804A JP 2022552804 A JP2022552804 A JP 2022552804A JP 7851562 B2 JP7851562 B2 JP 7851562B2
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Japan
Prior art keywords
acid
group
colan
dehydrogenase
dihydroxy
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JP2022552804A
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English (en)
Japanese (ja)
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JP2023516682A5 (https=
JP2023516682A (ja
Inventor
シュタウニッヒ、ニコール
オリビエ ドンスバッハ、カイ
Original Assignee
アンニッキ ゲーエムベーハー
ファーマツェル・ゲーエムベーハー
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Publication of JP2023516682A5 publication Critical patent/JP2023516682A5/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/14—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (1.14.14)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Steroid Compounds (AREA)
JP2022552804A 2020-03-06 2021-03-05 ステロイドのヒドロキシ化方法 Active JP7851562B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20161537.4 2020-03-06
EP20161537.4A EP3875597A1 (de) 2020-03-06 2020-03-06 Verfahren zur hydroxylierung von steroiden
PCT/EP2021/055615 WO2021176066A1 (de) 2020-03-06 2021-03-05 Verfahren zur hydroxylierung von steroiden

Publications (3)

Publication Number Publication Date
JP2023516682A JP2023516682A (ja) 2023-04-20
JP2023516682A5 JP2023516682A5 (https=) 2023-06-16
JP7851562B2 true JP7851562B2 (ja) 2026-04-27

Family

ID=69780053

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022552804A Active JP7851562B2 (ja) 2020-03-06 2021-03-05 ステロイドのヒドロキシ化方法

Country Status (5)

Country Link
US (1) US12601000B2 (https=)
EP (2) EP3875597A1 (https=)
JP (1) JP7851562B2 (https=)
KR (1) KR20220152553A (https=)
WO (1) WO2021176066A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117025709A (zh) * 2023-07-31 2023-11-10 华南理工大学 一种细胞色素p450酶联合细胞色素p450还原酶在合成熊去氧胆酸中的应用
NL2035768B1 (en) * 2023-09-08 2024-07-04 Centrient Pharmaceuticals Netherlands B V Method for hydroxylation of bile acids or analogues thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021176068A1 (de) 2020-03-06 2021-09-10 Pharmazell Gmbh Verfahren zur hydroxylierung von steroiden

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102002518B (zh) * 2010-10-28 2015-05-13 浙江大学 一种酶羟化3β-胆固醇乙酸酯制备7β-羟基-3β胆固醇乙酸酯的方法
CN109154016B (zh) * 2017-12-29 2021-11-16 邦泰生物工程(深圳)有限公司 一种化学-酶法制备熊去氧胆酸的方法
GB201819209D0 (en) * 2018-11-26 2019-01-09 Hypha Discovery Ltd Biocatalytic techniques

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021176068A1 (de) 2020-03-06 2021-09-10 Pharmazell Gmbh Verfahren zur hydroxylierung von steroiden

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
永田 清，"チトクロムＰ－４５０を介した薬物代謝"，日本薬理学雑誌，2009年，第134巻, 第3号，p.146－148

Also Published As

Publication number Publication date
US20240209410A1 (en) 2024-06-27
KR20220152553A (ko) 2022-11-16
EP3875597A1 (de) 2021-09-08
WO2021176066A1 (de) 2021-09-10
EP4114961A1 (de) 2023-01-11
US12601000B2 (en) 2026-04-14
JP2023516682A (ja) 2023-04-20

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