JP7848179B2 - リン脂質 - Google Patents

リン脂質

Info

Publication number
JP7848179B2
JP7848179B2 JP2023505328A JP2023505328A JP7848179B2 JP 7848179 B2 JP7848179 B2 JP 7848179B2 JP 2023505328 A JP2023505328 A JP 2023505328A JP 2023505328 A JP2023505328 A JP 2023505328A JP 7848179 B2 JP7848179 B2 JP 7848179B2
Authority
JP
Japan
Prior art keywords
phospholipid
acid
lipid particles
lipid
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2023505328A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2022190967A1 (https=
Inventor
康治 冨田
雄希 井上
綾乃 横内
尚文 深田
典之 前田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Fine Chemical Co Ltd
Original Assignee
Nippon Fine Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Fine Chemical Co Ltd filed Critical Nippon Fine Chemical Co Ltd
Publication of JPWO2022190967A1 publication Critical patent/JPWO2022190967A1/ja
Application granted granted Critical
Publication of JP7848179B2 publication Critical patent/JP7848179B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2023505328A 2021-03-09 2022-03-01 リン脂質 Active JP7848179B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2021037573 2021-03-09
JP2021037573 2021-03-09
PCT/JP2022/008670 WO2022190967A1 (ja) 2021-03-09 2022-03-01 リン脂質

Publications (2)

Publication Number Publication Date
JPWO2022190967A1 JPWO2022190967A1 (https=) 2022-09-15
JP7848179B2 true JP7848179B2 (ja) 2026-04-20

Family

ID=83227160

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023505328A Active JP7848179B2 (ja) 2021-03-09 2022-03-01 リン脂質

Country Status (5)

Country Link
US (1) US20230295199A1 (https=)
EP (1) EP4306531A4 (https=)
JP (1) JP7848179B2 (https=)
CN (1) CN116234538A (https=)
WO (1) WO2022190967A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120712274A (zh) * 2023-02-14 2025-09-26 静冈县公立大学法人 pH响应性磷脂

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005247750A (ja) 2004-03-04 2005-09-15 Takemoto Oil & Fat Co Ltd リン脂質誘導体及び遺伝子導入キャリア
WO2018190017A1 (ja) 2017-04-11 2018-10-18 日本精化株式会社 核酸導入用脂質誘導体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE787457A (fr) * 1971-08-14 1973-02-12 Basf Ag Derives de l'acide chloro-2-ethanephosphonique
DE2752553C2 (de) * 1977-11-24 1985-07-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Neue phospholipidartige Verbindungen, ihre Verwendung zur Herstellung von Pflanzenhybriden und Verfahren zu ihrer Herstellung
JPS6041494A (ja) * 1983-04-11 1985-03-05 Meito Sangyo Kk 酵素法リン脂質一級アルコ−ル誘導体の製法
DE10207177A1 (de) * 2002-02-19 2003-09-04 Novosom Ag Fakultativ kationische Lipide
WO2019005830A1 (en) * 2017-06-26 2019-01-03 Fordoz Pharma Corp. NANOSOME FORMULATIONS OF APREPITANT AND METHODS AND APPLICATIONS THEREOF

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005247750A (ja) 2004-03-04 2005-09-15 Takemoto Oil & Fat Co Ltd リン脂質誘導体及び遺伝子導入キャリア
WO2018190017A1 (ja) 2017-04-11 2018-10-18 日本精化株式会社 核酸導入用脂質誘導体

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ASAI, T. et al.，Dicetyl phosphate-tetraethylenepentamine-based liposomes for systemic siRNA delivery，Bioconjugate Chemistry，2011年，Vol. 22, No. 3，pp. 429-435
NAGATA, T. et al.，Fusion of plant protoplasts induced by a positively charged synthetic phospholipid，Zeitschrift fuer Naturforschung, C: Journal of Biosciences，Vol. 34C, No. 5-6，1979年，pp. 460-462
冨田 康治 他，ピペラジン骨格を有する新規機能性脂質の開発，第３６回日本ＤＤＳ学会学術集会プログラム予稿集，第３６回日本ＤＤＳ学会学術集会組織委員会，2020年08月10日，p. 197

Also Published As

Publication number Publication date
US20230295199A1 (en) 2023-09-21
EP4306531A1 (en) 2024-01-17
JPWO2022190967A1 (https=) 2022-09-15
WO2022190967A1 (ja) 2022-09-15
CN116234538A (zh) 2023-06-06
EP4306531A4 (en) 2025-02-19

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