CN116234538A - 磷脂 - Google Patents

磷脂 Download PDF

Info

Publication number
CN116234538A
CN116234538A CN202280006255.1A CN202280006255A CN116234538A CN 116234538 A CN116234538 A CN 116234538A CN 202280006255 A CN202280006255 A CN 202280006255A CN 116234538 A CN116234538 A CN 116234538A
Authority
CN
China
Prior art keywords
phospholipid
acid
lipid
present
hydrocarbon group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202280006255.1A
Other languages
English (en)
Chinese (zh)
Inventor
富田康治
井上雄希
横内绫乃
深田尚文
前田典之
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Fine Chemical Co Ltd
Original Assignee
Nippon Fine Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Fine Chemical Co Ltd filed Critical Nippon Fine Chemical Co Ltd
Publication of CN116234538A publication Critical patent/CN116234538A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202280006255.1A 2021-03-09 2022-03-01 磷脂 Pending CN116234538A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2021037573 2021-03-09
JP2021-037573 2021-03-09
PCT/JP2022/008670 WO2022190967A1 (ja) 2021-03-09 2022-03-01 リン脂質

Publications (1)

Publication Number Publication Date
CN116234538A true CN116234538A (zh) 2023-06-06

Family

ID=83227160

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280006255.1A Pending CN116234538A (zh) 2021-03-09 2022-03-01 磷脂

Country Status (5)

Country Link
US (1) US20230295199A1 (https=)
EP (1) EP4306531A4 (https=)
JP (1) JP7848179B2 (https=)
CN (1) CN116234538A (https=)
WO (1) WO2022190967A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120712274A (zh) * 2023-02-14 2025-09-26 静冈县公立大学法人 pH响应性磷脂

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE787457A (fr) * 1971-08-14 1973-02-12 Basf Ag Derives de l'acide chloro-2-ethanephosphonique
DE2752553C2 (de) * 1977-11-24 1985-07-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Neue phospholipidartige Verbindungen, ihre Verwendung zur Herstellung von Pflanzenhybriden und Verfahren zu ihrer Herstellung
JPS6041494A (ja) * 1983-04-11 1985-03-05 Meito Sangyo Kk 酵素法リン脂質一級アルコ−ル誘導体の製法
DE10207177A1 (de) * 2002-02-19 2003-09-04 Novosom Ag Fakultativ kationische Lipide
JP4442864B2 (ja) 2004-03-04 2010-03-31 竹本油脂株式会社 リン脂質誘導体及び遺伝子導入キャリア
CN110506047B (zh) 2017-04-11 2022-06-17 日本精化株式会社 核酸导入用脂质衍生物
WO2019005830A1 (en) * 2017-06-26 2019-01-03 Fordoz Pharma Corp. NANOSOME FORMULATIONS OF APREPITANT AND METHODS AND APPLICATIONS THEREOF

Also Published As

Publication number Publication date
US20230295199A1 (en) 2023-09-21
EP4306531A1 (en) 2024-01-17
JPWO2022190967A1 (https=) 2022-09-15
WO2022190967A1 (ja) 2022-09-15
JP7848179B2 (ja) 2026-04-20
EP4306531A4 (en) 2025-02-19

Similar Documents

Publication Publication Date Title
EP3239132B1 (en) Cationic lipid
CN107406396B (zh) 阳离子性脂质
CN111902397A (zh) 改进了细胞内动力学的阳离子脂质
EP4400107A1 (en) Ionizable liposome, preparation thereof, and application thereof in gene delivery
KR20140136047A (ko) 약물 송달 제어용 경폐 투여 리포좀
KR102758330B1 (ko) 황화물을 포함하는 이온화 가능한 지질 및 이를 포함하는 지질나노입자
EP4556000A1 (en) Lyophilized composition of nucleic-acid-loaded lipid nanoparticles
US11034708B2 (en) Lipid derivative for nucleic acid introduction
EP2140870B1 (en) Prompt nucleic acid delivery carrier composition
CN116234538A (zh) 磷脂
JP7748394B2 (ja) リン脂質
KR20240082389A (ko) 생분해성 이황화 결합을 포함하는 이온화 가능한 지질 및 이를 포함하는 지질나노입자
WO2025011532A1 (en) Lipid compounds for delivery of therapeutic agents and preparation method and its use thereof
CN118164866A (zh) 阳离子脂质化合物及其组合物和应用
JP2024084059A (ja) リン脂質
JP2002535251A (ja) 癌治療のための新規化合物
EP4667475A1 (en) Ph-responsive phospholipid
CN101176721B (zh) 六甲蜜胺脂质体及其制备方法
CN121909024A (zh) 包封有核酸的配体修饰脂质纳米颗粒的制造方法
WO2026084761A2 (en) Conformationally tunable lipid compositions and therapeutic uses thereof
CN116284006A (zh) 可电离脂质化合物、包含其的脂质载体及应用
JP2018024699A (ja) 脂質粒子および核酸送達キャリア
HK1139041B (en) Prompt nucleic acid delivery carrier composition

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination