JP7840511B2 - 抗クローディン１８抗体及びそれらの使用の方法 - Google Patents

抗クローディン１８抗体及びそれらの使用の方法

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Publication number
JP7840511B2
JP7840511B2 JP2021544859A JP2021544859A JP7840511B2 JP 7840511 B2 JP7840511 B2 JP 7840511B2 JP 2021544859 A JP2021544859 A JP 2021544859A JP 2021544859 A JP2021544859 A JP 2021544859A JP 7840511 B2 JP7840511 B2 JP 7840511B2
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seq
sequence
antibody
light chain
heavy chain
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JP2022519118A (ja
JP2022519118A5 (https=
Inventor
ハン リー，
ミン レイ，
イー ペイ，
ハイチュン フアン，
Original Assignee
石▲薬▼集▲団▼巨石生物制▲薬▼有限公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/80—Vaccine for a specifically defined cancer
    • A61K2039/828—Stomach
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/80—Vaccine for a specifically defined cancer
    • A61K2039/852—Pancreas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2021544859A 2019-02-01 2020-02-03 抗クローディン１８抗体及びそれらの使用の方法 Active JP7840511B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962800359P 2019-02-01 2019-02-01
US62/800,359 2019-02-01
US201962891925P 2019-08-26 2019-08-26
US62/891,925 2019-08-26
PCT/US2020/016459 WO2020160560A2 (en) 2019-02-01 2020-02-03 Anti-claudin 18 antibodies and methods of use thereof

Publications (3)

Publication Number Publication Date
JP2022519118A JP2022519118A (ja) 2022-03-18
JP2022519118A5 JP2022519118A5 (https=) 2023-01-30
JP7840511B2 true JP7840511B2 (ja) 2026-04-06

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JP2021544859A Active JP7840511B2 (ja) 2019-02-01 2020-02-03 抗クローディン１８抗体及びそれらの使用の方法

Country Status (8)

Country Link
US (3) US11407828B2 (https=)
EP (1) EP3917564A4 (https=)
JP (1) JP7840511B2 (https=)
KR (1) KR20210134321A (https=)
CN (1) CN113645996B (https=)
CA (1) CA3128502A1 (https=)
SG (1) SG11202108398YA (https=)
WO (1) WO2020160560A2 (https=)

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WO2022206975A1 (zh) * 2021-04-02 2022-10-06 原启生物科技(上海)有限责任公司 Cldn18.2抗原结合蛋白及其用途
US12600774B2 (en) * 2021-05-31 2026-04-14 Shijiazhuang Yiling Pharmaceutical Co., Ltd. Monoclonal antibodies against CLDN18.2 and Fc-engineered versions thereof
US20250251400A1 (en) 2021-11-05 2025-08-07 American Diagnostics & Therapy, Llc (Adxrx) Monoclonal Antibodies Against Carcinoembryonic Antigens, and Their Uses
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KR20240101987A (ko) * 2022-12-23 2024-07-03 주식회사 와이바이오로직스 클라우딘-18.2에 특이적으로 결합하는 단클론항체 및 이의 용도
TW202434307A (zh) 2023-01-18 2024-09-01 大陸商泰勵生物科技（上海）有限公司 抗體偶聯藥物及其用途
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Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2018006882A1 (zh) 2016-07-08 2018-01-11 科济生物医药（上海）有限公司 抗密蛋白18a2的抗体及其应用

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US20230272063A1 (en) 2023-08-31
JP2022519118A (ja) 2022-03-18
WO2020160560A3 (en) 2020-09-17
EP3917564A4 (en) 2022-12-21
SG11202108398YA (en) 2021-08-30
CN113645996A (zh) 2021-11-12
KR20210134321A (ko) 2021-11-09
US20220041712A1 (en) 2022-02-10
WO2020160560A2 (en) 2020-08-06
CA3128502A1 (en) 2020-08-06
AU2020217012A1 (en) 2021-08-19
US20230067757A1 (en) 2023-03-02
CN113645996B (zh) 2024-04-02
US11407828B2 (en) 2022-08-09
EP3917564A2 (en) 2021-12-08

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