SG11202108398YA - Anti-claudin 18 antibodies and methods of use thereof - Google Patents
Anti-claudin 18 antibodies and methods of use thereofInfo
- Publication number
- SG11202108398YA SG11202108398YA SG11202108398YA SG11202108398YA SG11202108398YA SG 11202108398Y A SG11202108398Y A SG 11202108398YA SG 11202108398Y A SG11202108398Y A SG 11202108398YA SG 11202108398Y A SG11202108398Y A SG 11202108398YA SG 11202108398Y A SG11202108398Y A SG 11202108398YA
- Authority
- SG
- Singapore
- Prior art keywords
- claudin
- antibodies
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/828—Stomach
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/852—Pancreas
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962800359P | 2019-02-01 | 2019-02-01 | |
| US201962891925P | 2019-08-26 | 2019-08-26 | |
| PCT/US2020/016459 WO2020160560A2 (en) | 2019-02-01 | 2020-02-03 | Anti-claudin 18 antibodies and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202108398YA true SG11202108398YA (en) | 2021-08-30 |
Family
ID=71842386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202108398YA SG11202108398YA (en) | 2019-02-01 | 2020-02-03 | Anti-claudin 18 antibodies and methods of use thereof |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US11407828B2 (https=) |
| EP (1) | EP3917564A4 (https=) |
| JP (1) | JP7840511B2 (https=) |
| KR (1) | KR20210134321A (https=) |
| CN (1) | CN113645996B (https=) |
| CA (1) | CA3128502A1 (https=) |
| SG (1) | SG11202108398YA (https=) |
| WO (1) | WO2020160560A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11643455B2 (en) | 2018-04-13 | 2023-05-09 | Albert Einstein College Of Medicine | High-affinity Mycobacterium tuberculosis capsule-specific human monoclonal antibody |
| KR20210110339A (ko) * | 2018-12-28 | 2021-09-07 | 난징 진스크립트 바이오테크 컴퍼니 리미티드 | 클라우딘18.2 결합 모이어티 및 그 용도 |
| SG11202108398YA (en) * | 2019-02-01 | 2021-08-30 | Novarock Biotherapeutics Ltd | Anti-claudin 18 antibodies and methods of use thereof |
| AU2021354827A1 (en) * | 2020-09-30 | 2023-06-01 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Pharmaceutical composition comprising antibody-drug conjugate, and use of pharmaceutical composition |
| EP4252782A4 (en) * | 2020-11-30 | 2025-12-10 | Cspc Megalith Biopharmaceutical Co Ltd | ANTI-CLDN18.2 ANTIBODY, DRUG CONJUGATE, RELATED PREPARATION METHOD AND ASSOCIATED USE |
| WO2022122709A1 (en) | 2020-12-07 | 2022-06-16 | Sotio Biotech A.S. | Antibody-drug conjugates based on humanized cldn18.2 antibodies |
| US20240101650A1 (en) * | 2020-12-15 | 2024-03-28 | Albert Einstein College Of Medicine | High-Affinity Mycobacterium Tuberculosis Capsule-Specific Human Monoclonal Antibody |
| US20240043937A1 (en) * | 2020-12-22 | 2024-02-08 | Bertis Inc | Method for determining subtype of pancreatic ductal adenocarcinoma, and subtype determination kit |
| TW202241519A (zh) | 2020-12-23 | 2022-11-01 | 捷克商舒迪安生物技術公司 | 腫瘤特異性密連蛋白１８﹒２抗體藥物結合物 |
| WO2022206975A1 (zh) * | 2021-04-02 | 2022-10-06 | 原启生物科技(上海)有限责任公司 | Cldn18.2抗原结合蛋白及其用途 |
| US12600774B2 (en) * | 2021-05-31 | 2026-04-14 | Shijiazhuang Yiling Pharmaceutical Co., Ltd. | Monoclonal antibodies against CLDN18.2 and Fc-engineered versions thereof |
| US20250251400A1 (en) | 2021-11-05 | 2025-08-07 | American Diagnostics & Therapy, Llc (Adxrx) | Monoclonal Antibodies Against Carcinoembryonic Antigens, and Their Uses |
| EP4534103A1 (en) * | 2022-05-31 | 2025-04-09 | CSPC Megalith Biopharmaceutical Co., Ltd. | Pharmaceutical composition of recombinant anti-human cldn18.2 monoclonal antibody-mmae conjugate |
| CN117777288A (zh) * | 2022-09-29 | 2024-03-29 | 南京博望医药科技有限公司 | 抗密蛋白18.2的抗体 |
| KR20240101987A (ko) * | 2022-12-23 | 2024-07-03 | 주식회사 와이바이오로직스 | 클라우딘-18.2에 특이적으로 결합하는 단클론항체 및 이의 용도 |
| TW202434307A (zh) | 2023-01-18 | 2024-09-01 | 大陸商泰勵生物科技（上海）有限公司 | 抗體偶聯藥物及其用途 |
| WO2024211459A1 (en) * | 2023-04-04 | 2024-10-10 | Zai Lab (Shanghai) Co., Ltd | Use of anti-claudin antibody for cancer treatment based on certain biomarkers |
| CN118530349B (zh) * | 2024-06-03 | 2025-04-11 | 华中农业大学 | 一株可中和猪轮状病毒不同血清型毒株的单克隆抗体 |
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| KR20210050547A (ko) | 2018-08-27 | 2021-05-07 | 난징 산홈 팔마세우티칼 컴퍼니 리미티드 | 항-클라우딘18.2 항체 및 이의 용도 |
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| CN109762067B (zh) | 2019-01-17 | 2020-02-28 | 北京天广实生物技术股份有限公司 | 结合人Claudin 18.2的抗体及其用途 |
| SG11202108398YA (en) * | 2019-02-01 | 2021-08-30 | Novarock Biotherapeutics Ltd | Anti-claudin 18 antibodies and methods of use thereof |
| WO2020205331A1 (en) | 2019-03-29 | 2020-10-08 | Phanes Therapeutics, Inc. | Humanized anti-claudin 18.2 chimeric antigen receptors and uses thereof |
| KR20210148216A (ko) | 2019-04-01 | 2021-12-07 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 항-클라우딘 18.2 항체 및 이의 응용 |
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| CA3136281C (en) | 2019-05-30 | 2024-06-25 | Shandong Boan Biotechnology Co., Ltd. | Antibody or chimeric antigen receptor which targets claudin 18.2 |
| KR102773187B1 (ko) | 2019-07-12 | 2025-02-27 | 퓨쳐진 바이오파머쓰티컬 (베이징) 코., 엘티디. | Cldn18.2 항체 및 이의 용도 |
| KR102777693B1 (ko) | 2019-07-17 | 2025-03-07 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | Claudin18 항체 및 암 치료 방법 |
| JP7767270B2 (ja) * | 2019-08-20 | 2025-11-11 | スーチョウ トランセンタ セラピューティクス カンパニー，リミテッド | 新規抗ｃｌｄｎ１８．２抗体 |
-
2020
- 2020-02-03 SG SG11202108398YA patent/SG11202108398YA/en unknown
- 2020-02-03 WO PCT/US2020/016459 patent/WO2020160560A2/en not_active Ceased
- 2020-02-03 JP JP2021544859A patent/JP7840511B2/ja active Active
- 2020-02-03 CN CN202080025850.0A patent/CN113645996B/zh active Active
- 2020-02-03 KR KR1020217027503A patent/KR20210134321A/ko active Pending
- 2020-02-03 US US17/427,909 patent/US11407828B2/en active Active
- 2020-02-03 EP EP20748335.5A patent/EP3917564A4/en active Pending
- 2020-02-03 CA CA3128502A patent/CA3128502A1/en active Pending
-
2022
- 2022-06-22 US US17/846,709 patent/US20230067757A1/en active Pending
- 2022-07-13 US US17/864,335 patent/US20230272063A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20230272063A1 (en) | 2023-08-31 |
| JP2022519118A (ja) | 2022-03-18 |
| WO2020160560A3 (en) | 2020-09-17 |
| EP3917564A4 (en) | 2022-12-21 |
| CN113645996A (zh) | 2021-11-12 |
| KR20210134321A (ko) | 2021-11-09 |
| US20220041712A1 (en) | 2022-02-10 |
| WO2020160560A2 (en) | 2020-08-06 |
| CA3128502A1 (en) | 2020-08-06 |
| JP7840511B2 (ja) | 2026-04-06 |
| AU2020217012A1 (en) | 2021-08-19 |
| US20230067757A1 (en) | 2023-03-02 |
| CN113645996B (zh) | 2024-04-02 |
| US11407828B2 (en) | 2022-08-09 |
| EP3917564A2 (en) | 2021-12-08 |
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