JP7830129B2 - 標的遺伝子編集構築物およびそれを使用する方法 - Google Patents

標的遺伝子編集構築物およびそれを使用する方法

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JP7830129B2
JP7830129B2 JP2021574234A JP2021574234A JP7830129B2 JP 7830129 B2 JP7830129 B2 JP 7830129B2 JP 2021574234 A JP2021574234 A JP 2021574234A JP 2021574234 A JP2021574234 A JP 2021574234A JP 7830129 B2 JP7830129 B2 JP 7830129B2
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nucleic acid
dna
cells
sequence
protein
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JP2022540318A (ja
JP2022540318A5 (https=
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ガルシア，アベンシア サンチェス－メヒアズ
カルゴル，マルク グエル
ジェルマノヴィッチ，ディミトリエ イヴァンチッチ
パジャーレス，マスミーチャ，マリア
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ウニベルシタット ポンペウ ファブラ
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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    • C07K2319/00—Fusion polypeptide
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    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
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    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
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  • Crystallography & Structural Chemistry (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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  • Enzymes And Modification Thereof (AREA)
JP2021574234A 2019-06-11 2020-06-11 標的遺伝子編集構築物およびそれを使用する方法 Active JP7830129B2 (ja)

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US201962860186P 2019-06-11 2019-06-11
US62/860,186 2019-06-11
PCT/IB2020/055507 WO2020250181A1 (en) 2019-06-11 2020-06-11 Targeted gene editing constructs and methods of using the same

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JP2022540318A JP2022540318A (ja) 2022-09-15
JP2022540318A5 JP2022540318A5 (https=) 2023-07-19
JP7830129B2 true JP7830129B2 (ja) 2026-03-16

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US (1) US20220235379A1 (https=)
EP (1) EP3983541A1 (https=)
JP (1) JP7830129B2 (https=)
KR (1) KR20220019794A (https=)
CN (1) CN114026240A (https=)
AU (1) AU2020290790B2 (https=)
BR (1) BR112021024828A2 (https=)
CA (1) CA3141422A1 (https=)
IL (1) IL288794A (https=)
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JP7419168B2 (ja) * 2020-06-10 2024-01-22 株式会社東芝 改変型ｐｉｇｇｙＢａｃトランスポゼースのポリペプチド、それをコードするポリヌクレオチド、導入キャリア、キット、細胞のゲノムに目的配列を組込む方法及び細胞製造方法
AU2021403660A1 (en) 2020-12-16 2023-07-06 Universitat Pompeu Fabra Programmable transposases and uses thereof
JP2023553701A (ja) * 2020-12-16 2023-12-25 ウニベルシタット ポンペウ ファブラ 先天性筋ジストロフィーの処置のための治療用ｌａｍａ２ペイロード
EP4341392A4 (en) * 2021-05-14 2025-02-19 Becton Dickinson and Company Multiplexed unbiased nucleic acid amplification method
CA3234642A1 (en) * 2021-10-04 2023-04-13 Poseida Therapeutics, Inc. Transposases and uses thereof
JP2024545923A (ja) * 2021-12-30 2024-12-13 リーゲル セラピューティクス，インコーポレイティッド ナトリウム電位依存性チャネルアルファサブユニット１の発現を調節するための組成物、及びその使用
WO2023141504A2 (en) * 2022-01-19 2023-07-27 Genomeminer, Inc. (Formally Tupac Bio, Inc.) Dcas9-integrase for targeted genome editing
KR20230122932A (ko) 2022-02-15 2023-08-22 주식회사 엘지에너지솔루션 이차전지 제조장치 및 이를 이용하는 이차전지 제조방법
CN116218904B (zh) * 2022-11-03 2025-04-15 国药中生生物技术研究院有限公司 一种可提高工程化细胞外泌体中特定核酸分子载量的方法及其应用
CN118185901B (zh) * 2022-12-12 2025-03-21 北京精缮生物科技有限责任公司 一种PBase蛋白、融合蛋白、核酸和基因整合系统及应用
JP2026511237A (ja) * 2023-03-27 2026-04-10 ベイジン・アストラジェノミクス・テクノロジー・カンパニー，リミテッド 単離されたトランスポザーゼ及びその使用
CN121712899A (zh) * 2023-04-27 2026-03-20 伦斯勒理工学院 用于在真核细胞中准确插入dna序列的重组酶
CN121443733A (zh) 2023-06-01 2026-01-30 英特格拉治疗公司 转座酶及其用途
WO2025212757A2 (en) * 2024-04-03 2025-10-09 Buck Institute For Research On Aging Cas enabled targeted transposition
CN119842638A (zh) * 2025-01-20 2025-04-18 天津大学 融合酶突变体及其在氟代白藜芦醇合成中的应用

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WO2018175872A1 (en) 2017-03-24 2018-09-27 President And Fellows Of Harvard College Methods of genome engineering by nuclease-transposase fusion proteins

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JP2018513681A (ja) 2015-03-31 2018-05-31 エクセリゲン サイエンティフィック, インコーポレイテッドExeligen Scientific, Inc. 細胞または生物のゲノムへのＤＮＡ配列の標的化組み込みのためのＣａｓ９レトロウイルスインテグラーゼおよびＣａｓ９レコンビナーゼ系
WO2018175872A1 (en) 2017-03-24 2018-09-27 President And Fellows Of Harvard College Methods of genome engineering by nuclease-transposase fusion proteins

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MX2021015157A (es) 2022-03-17
AU2020290790B2 (en) 2026-02-19
CA3141422A1 (en) 2020-12-17
IL288794A (en) 2022-02-01
KR20220019794A (ko) 2022-02-17
AU2020290790A1 (en) 2022-01-27
WO2020250181A1 (en) 2020-12-17
EP3983541A1 (en) 2022-04-20
CN114026240A (zh) 2022-02-08
JP2022540318A (ja) 2022-09-15
US20220235379A1 (en) 2022-07-28
BR112021024828A2 (pt) 2022-01-25

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