KR20220019794A - 표적화된 유전자 편집 작제물 및 이의 사용 방법 - Google Patents

표적화된 유전자 편집 작제물 및 이의 사용 방법 Download PDF

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KR20220019794A
KR20220019794A KR1020227000857A KR20227000857A KR20220019794A KR 20220019794 A KR20220019794 A KR 20220019794A KR 1020227000857 A KR1020227000857 A KR 1020227000857A KR 20227000857 A KR20227000857 A KR 20227000857A KR 20220019794 A KR20220019794 A KR 20220019794A
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nucleic acid
amino acid
sequence
protein
modified
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Korean (ko)
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아벤시아 산체스-메지아스 가르시아
마르크 구엘 카골
디미트리 이반식 제르마노비치
마리아 팔라로스 마스미차
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우니베르시타트 폼페우 파브라
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Publication of KR20220019794A publication Critical patent/KR20220019794A/ko
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N9/10—Transferases (2.)
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
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    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
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KR1020227000857A 2019-06-11 2020-06-11 표적화된 유전자 편집 작제물 및 이의 사용 방법 Pending KR20220019794A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962860186P 2019-06-11 2019-06-11
US62/860,186 2019-06-11
PCT/IB2020/055507 WO2020250181A1 (en) 2019-06-11 2020-06-11 Targeted gene editing constructs and methods of using the same

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KR20220019794A true KR20220019794A (ko) 2022-02-17

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KR1020227000857A Pending KR20220019794A (ko) 2019-06-11 2020-06-11 표적화된 유전자 편집 작제물 및 이의 사용 방법

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US (1) US20220235379A1 (https=)
EP (1) EP3983541A1 (https=)
JP (1) JP7830129B2 (https=)
KR (1) KR20220019794A (https=)
CN (1) CN114026240A (https=)
AU (1) AU2020290790B2 (https=)
BR (1) BR112021024828A2 (https=)
CA (1) CA3141422A1 (https=)
IL (1) IL288794A (https=)
MX (1) MX2021015157A (https=)
WO (1) WO2020250181A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE212023000154U1 (de) 2022-02-15 2024-12-02 Lg Energy Solution, Ltd. Vorrichtung zum Herstellen einer Sekundärbatterie

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JP7419168B2 (ja) * 2020-06-10 2024-01-22 株式会社東芝 改変型ｐｉｇｇｙＢａｃトランスポゼースのポリペプチド、それをコードするポリヌクレオチド、導入キャリア、キット、細胞のゲノムに目的配列を組込む方法及び細胞製造方法
AU2021403660A1 (en) 2020-12-16 2023-07-06 Universitat Pompeu Fabra Programmable transposases and uses thereof
JP2023553701A (ja) * 2020-12-16 2023-12-25 ウニベルシタット ポンペウ ファブラ 先天性筋ジストロフィーの処置のための治療用ｌａｍａ２ペイロード
EP4341392A4 (en) * 2021-05-14 2025-02-19 Becton Dickinson and Company Multiplexed unbiased nucleic acid amplification method
CA3234642A1 (en) * 2021-10-04 2023-04-13 Poseida Therapeutics, Inc. Transposases and uses thereof
JP2024545923A (ja) * 2021-12-30 2024-12-13 リーゲル セラピューティクス，インコーポレイティッド ナトリウム電位依存性チャネルアルファサブユニット１の発現を調節するための組成物、及びその使用
WO2023141504A2 (en) * 2022-01-19 2023-07-27 Genomeminer, Inc. (Formally Tupac Bio, Inc.) Dcas9-integrase for targeted genome editing
CN116218904B (zh) * 2022-11-03 2025-04-15 国药中生生物技术研究院有限公司 一种可提高工程化细胞外泌体中特定核酸分子载量的方法及其应用
CN118185901B (zh) * 2022-12-12 2025-03-21 北京精缮生物科技有限责任公司 一种PBase蛋白、融合蛋白、核酸和基因整合系统及应用
JP2026511237A (ja) * 2023-03-27 2026-04-10 ベイジン・アストラジェノミクス・テクノロジー・カンパニー，リミテッド 単離されたトランスポザーゼ及びその使用
CN121712899A (zh) * 2023-04-27 2026-03-20 伦斯勒理工学院 用于在真核细胞中准确插入dna序列的重组酶
CN121443733A (zh) 2023-06-01 2026-01-30 英特格拉治疗公司 转座酶及其用途
WO2025212757A2 (en) * 2024-04-03 2025-10-09 Buck Institute For Research On Aging Cas enabled targeted transposition
CN119842638A (zh) * 2025-01-20 2025-04-18 天津大学 融合酶突变体及其在氟代白藜芦醇合成中的应用

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DE60335637D1 (de) * 2002-07-24 2011-02-17 Manoa Biosciences Inc Vektoren auf transposonbasis und verfahren zur integration von nukleinsäuren
WO2013012824A2 (en) * 2011-07-15 2013-01-24 The Johns Hopkins University Trichoplusia ni piggybac transposases with reduced integration activity
US20170114333A1 (en) * 2014-04-11 2017-04-27 The Johns Hopkins University Improvements to eukaryotic transposase mutants and transposon end compositions for modifying nucleic acids and methods for production and use in the generation of sequencing libraries
JP2018513681A (ja) * 2015-03-31 2018-05-31 エクセリゲン サイエンティフィック, インコーポレイテッドExeligen Scientific, Inc. 細胞または生物のゲノムへのＤＮＡ配列の標的化組み込みのためのＣａｓ９レトロウイルスインテグラーゼおよびＣａｓ９レコンビナーゼ系
KR102249982B1 (ko) * 2015-12-14 2021-05-11 게놈프론티어 테라퓨틱스 인코포레이티드 트랜스포존 시스템, 이를 포함한 키트, 및 이들의 용도
WO2018175872A1 (en) * 2017-03-24 2018-09-27 President And Fellows Of Harvard College Methods of genome engineering by nuclease-transposase fusion proteins

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE212023000154U1 (de) 2022-02-15 2024-12-02 Lg Energy Solution, Ltd. Vorrichtung zum Herstellen einer Sekundärbatterie

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MX2021015157A (es) 2022-03-17
JP7830129B2 (ja) 2026-03-16
AU2020290790B2 (en) 2026-02-19
CA3141422A1 (en) 2020-12-17
IL288794A (en) 2022-02-01
AU2020290790A1 (en) 2022-01-27
WO2020250181A1 (en) 2020-12-17
EP3983541A1 (en) 2022-04-20
CN114026240A (zh) 2022-02-08
JP2022540318A (ja) 2022-09-15
US20220235379A1 (en) 2022-07-28
BR112021024828A2 (pt) 2022-01-25

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