JP7829478B2 - Ａｐｏｃ３関連疾患および障害の処置のための方法 - Google Patents

Ａｐｏｃ３関連疾患および障害の処置のための方法

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JP7829478B2
JP7829478B2 JP2022506919A JP2022506919A JP7829478B2 JP 7829478 B2 JP7829478 B2 JP 7829478B2 JP 2022506919 A JP2022506919 A JP 2022506919A JP 2022506919 A JP2022506919 A JP 2022506919A JP 7829478 B2 JP7829478 B2 JP 7829478B2
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apoc3
dose
approximately
pharmaceutical composition
apoc3 rnai
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JP2022543136A (ja
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Inventor
ブルース ディー． ギブン，
ジェイムズ シー． ハミルトン，
ステイシー メルクイスト，
ゼン リ，
ルイ ジュー，
タオ ペイ，
スティーブン カナー，
ソ ウォン，
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アローヘッド ファーマシューティカルズ インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61K9/0012—Galenical forms characterised by the site of application
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    • C12N2310/30—Chemical structure
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  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Zoology (AREA)
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  • Obesity (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2022506919A 2019-08-05 2020-08-04 Ａｐｏｃ３関連疾患および障害の処置のための方法 Active JP7829478B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025012194A JP2025061882A (ja) 2019-08-05 2025-01-28 Ａｐｏｃ３関連疾患および障害の処置のための方法

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962883046P 2019-08-05 2019-08-05
US62/883,046 2019-08-05
US201962936559P 2019-11-17 2019-11-17
US62/936,559 2019-11-17
US202062970613P 2020-02-05 2020-02-05
US62/970,613 2020-02-05
PCT/US2020/044879 WO2021026150A1 (en) 2019-08-05 2020-08-04 Methods for the treatment of apoc3-related diseases and disorders

Related Child Applications (1)

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JP2025012194A Division JP2025061882A (ja) 2019-08-05 2025-01-28 Ａｐｏｃ３関連疾患および障害の処置のための方法

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JP2022543136A JP2022543136A (ja) 2022-10-07
JP2022543136A5 JP2022543136A5 (https=) 2023-08-14
JP7829478B2 true JP7829478B2 (ja) 2026-03-13

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JP2022506919A Active JP7829478B2 (ja) 2019-08-05 2020-08-04 Ａｐｏｃ３関連疾患および障害の処置のための方法
JP2025012194A Pending JP2025061882A (ja) 2019-08-05 2025-01-28 Ａｐｏｃ３関連疾患および障害の処置のための方法

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US (1) US20220152079A1 (https=)
EP (1) EP4010075A4 (https=)
JP (2) JP7829478B2 (https=)
KR (1) KR20220044551A (https=)
CN (1) CN114555188A (https=)
CA (1) CA3147725A1 (https=)
MX (1) MX2022001460A (https=)
TW (1) TW202120104A (https=)
WO (1) WO2021026150A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201901841TA (en) * 2016-09-02 2019-03-28 Arrowhead Pharmaceuticals Inc Targeting ligands
CN114934074A (zh) * 2022-06-01 2022-08-23 北京大学 一种ApoC3基因敲除仓鼠模型的构建方法
AU2024280172A1 (en) 2023-06-01 2025-12-04 Sunshine Lake Pharma Co., Ltd. Novel double-stranded sirna, conjugate thereof, and use thereof
KR20260032888A (ko) * 2024-08-30 2026-03-10 올릭스 주식회사 APOC3 유전자를 표적으로 하는 RNAi 제제 및 이의 용도

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014524738A (ja) 2011-06-21 2014-09-25 アルナイラム ファーマシューティカルズ， インコーポレイテッド アンジオポエチン様３（ＡＮＧＰＴＬ３）ｉＲＮＡ組成物及びその使用方法
JP2017535552A (ja) 2014-11-17 2017-11-30 アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用方法
WO2018223073A1 (en) 2017-06-02 2018-12-06 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof
WO2019105419A1 (zh) 2017-12-01 2019-06-06 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途

Family Cites Families (4)

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Publication number Priority date Publication date Assignee Title
KR101383006B1 (ko) * 2009-02-10 2014-04-08 아마린 파마, 인크. 고중성지방혈증 치료 방법
MX390699B (es) * 2011-06-21 2025-03-21 Alnylam Pharmaceuticals Inc Composiciones y metodos para inhibicion de genes para apolipoproteina c-iii (apoc3).
WO2018112320A1 (en) * 2016-12-16 2018-06-21 Alnylam Pharmaceuticals, Inc. Methods for treating or preventing ttr-associated diseases using transthyretin (ttr) irna compositions
KR20240161202A (ko) * 2017-09-11 2024-11-12 애로우헤드 파마슈티컬스 인코포레이티드 아포지단백질 C-III (APOC3)의 발현을 억제하기 위한 RNAi 작용제 및 조성물

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014524738A (ja) 2011-06-21 2014-09-25 アルナイラム ファーマシューティカルズ， インコーポレイテッド アンジオポエチン様３（ＡＮＧＰＴＬ３）ｉＲＮＡ組成物及びその使用方法
JP2017535552A (ja) 2014-11-17 2017-11-30 アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用方法
WO2018223073A1 (en) 2017-06-02 2018-12-06 Wave Life Sciences Ltd. Oligonucleotide compositions and methods of use thereof
WO2019105419A1 (zh) 2017-12-01 2019-06-06 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途

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Publication number Publication date
MX2022001460A (es) 2022-02-22
CN114555188A (zh) 2022-05-27
WO2021026150A1 (en) 2021-02-11
AU2020324974A1 (en) 2022-02-24
CA3147725A1 (en) 2021-02-11
KR20220044551A (ko) 2022-04-08
JP2022543136A (ja) 2022-10-07
EP4010075A4 (en) 2023-11-15
TW202120104A (zh) 2021-06-01
JP2025061882A (ja) 2025-04-11
US20220152079A1 (en) 2022-05-19
EP4010075A1 (en) 2022-06-15

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