CN114555188A - 治疗apoc3相关疾病和病症的方法 - Google Patents

治疗apoc3相关疾病和病症的方法 Download PDF

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Publication number
CN114555188A
CN114555188A CN202080069368.7A CN202080069368A CN114555188A CN 114555188 A CN114555188 A CN 114555188A CN 202080069368 A CN202080069368 A CN 202080069368A CN 114555188 A CN114555188 A CN 114555188A
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dose
pharmaceutical composition
apoc3
apoc3 rnai
drug substance
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CN202080069368.7A
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Chinese (zh)
Inventor
B·D·吉文
J·C·哈米尔顿
S·梅尔奎斯特
李珍
朱锐
裴涛
S·肯纳
S·王
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Arrowhead Pharmaceuticals Inc
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Arrowhead Pharmaceuticals Inc
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CN202080069368.7A 2019-08-05 2020-08-04 治疗apoc3相关疾病和病症的方法 Pending CN114555188A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962883046P 2019-08-05 2019-08-05
US62/883046 2019-08-05
US201962936559P 2019-11-17 2019-11-17
US62/936559 2019-11-17
US202062970613P 2020-02-05 2020-02-05
US62/970613 2020-02-05
PCT/US2020/044879 WO2021026150A1 (en) 2019-08-05 2020-08-04 Methods for the treatment of apoc3-related diseases and disorders

Publications (1)

Publication Number Publication Date
CN114555188A true CN114555188A (zh) 2022-05-27

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CN202080069368.7A Pending CN114555188A (zh) 2019-08-05 2020-08-04 治疗apoc3相关疾病和病症的方法

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US (1) US20220152079A1 (https=)
EP (1) EP4010075A4 (https=)
JP (2) JP7829478B2 (https=)
KR (1) KR20220044551A (https=)
CN (1) CN114555188A (https=)
CA (1) CA3147725A1 (https=)
MX (1) MX2022001460A (https=)
TW (1) TW202120104A (https=)
WO (1) WO2021026150A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024245381A1 (zh) 2023-06-01 2024-12-05 广东东阳光药业股份有限公司 一种新型的双链siRNA、其缀合物及其用途

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201901841TA (en) * 2016-09-02 2019-03-28 Arrowhead Pharmaceuticals Inc Targeting ligands
CN114934074A (zh) * 2022-06-01 2022-08-23 北京大学 一种ApoC3基因敲除仓鼠模型的构建方法
KR20260032888A (ko) * 2024-08-30 2026-03-10 올릭스 주식회사 APOC3 유전자를 표적으로 하는 RNAi 제제 및 이의 용도

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
KR101383006B1 (ko) * 2009-02-10 2014-04-08 아마린 파마, 인크. 고중성지방혈증 치료 방법
MX390699B (es) * 2011-06-21 2025-03-21 Alnylam Pharmaceuticals Inc Composiciones y metodos para inhibicion de genes para apolipoproteina c-iii (apoc3).
EP2723758B1 (en) * 2011-06-21 2018-06-20 Alnylam Pharmaceuticals, Inc. Angiopoietin-like 3 (angptl3) irna compostions and methods of use thereof
JP2017535552A (ja) * 2014-11-17 2017-11-30 アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用方法
WO2018112320A1 (en) * 2016-12-16 2018-06-21 Alnylam Pharmaceuticals, Inc. Methods for treating or preventing ttr-associated diseases using transthyretin (ttr) irna compositions
CN120330183A (zh) * 2017-06-02 2025-07-18 波涛生命科学有限公司 寡核苷酸组合物及其使用方法
KR20240161202A (ko) * 2017-09-11 2024-11-12 애로우헤드 파마슈티컬스 인코포레이티드 아포지단백질 C-III (APOC3)의 발현을 억제하기 위한 RNAi 작용제 및 조성물
EP3719127A4 (en) * 2017-12-01 2021-10-20 Suzhou Ribo Life Science Co., Ltd. NUCLEIC ACID, COMPOSITION AND CONJUGATE WITH IT, MANUFACTURING METHOD AND USE

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024245381A1 (zh) 2023-06-01 2024-12-05 广东东阳光药业股份有限公司 一种新型的双链siRNA、其缀合物及其用途

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MX2022001460A (es) 2022-02-22
WO2021026150A1 (en) 2021-02-11
AU2020324974A1 (en) 2022-02-24
CA3147725A1 (en) 2021-02-11
KR20220044551A (ko) 2022-04-08
JP2022543136A (ja) 2022-10-07
JP7829478B2 (ja) 2026-03-13
EP4010075A4 (en) 2023-11-15
TW202120104A (zh) 2021-06-01
JP2025061882A (ja) 2025-04-11
US20220152079A1 (en) 2022-05-19
EP4010075A1 (en) 2022-06-15

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