JP7825613B2 - オリゴ核酸化合物の製造方法 - Google Patents
オリゴ核酸化合物の製造方法Info
- Publication number
- JP7825613B2 JP7825613B2 JP2023517605A JP2023517605A JP7825613B2 JP 7825613 B2 JP7825613 B2 JP 7825613B2 JP 2023517605 A JP2023517605 A JP 2023517605A JP 2023517605 A JP2023517605 A JP 2023517605A JP 7825613 B2 JP7825613 B2 JP 7825613B2
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkyl
- phosphoryl
- morpholin
- dimethylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021076609 | 2021-04-28 | ||
| JP2021076609 | 2021-04-28 | ||
| PCT/JP2022/019139 WO2022230954A1 (ja) | 2021-04-28 | 2022-04-27 | オリゴ核酸化合物の製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2022230954A1 JPWO2022230954A1 (https=) | 2022-11-03 |
| JPWO2022230954A5 JPWO2022230954A5 (https=) | 2025-01-22 |
| JP7825613B2 true JP7825613B2 (ja) | 2026-03-06 |
Family
ID=83848560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023517605A Active JP7825613B2 (ja) | 2021-04-28 | 2022-04-27 | オリゴ核酸化合物の製造方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20240254158A1 (https=) |
| EP (1) | EP4332111A4 (https=) |
| JP (1) | JP7825613B2 (https=) |
| KR (1) | KR20240004559A (https=) |
| CN (1) | CN117279926A (https=) |
| AU (1) | AU2022266379A1 (https=) |
| CA (1) | CA3218264A1 (https=) |
| WO (1) | WO2022230954A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3244382A1 (en) * | 2021-12-27 | 2025-02-26 | Nippon Shinyaku Co., Ltd. | PROCESS FOR THE PRODUCTION OF OLIGONUCLEIC ACID COMPOUNDS |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005028494A1 (ja) | 2003-09-02 | 2005-03-31 | Takeshi Wada | ５'-ホスフィチル化モノマーおよびh-ホスホネートオリゴヌクレオチド誘導体の製造方法 |
| WO2012043730A1 (ja) | 2010-09-30 | 2012-04-05 | 日本新薬株式会社 | モルホリノ核酸誘導体 |
| WO2014189142A1 (ja) | 2013-05-24 | 2014-11-27 | 味の素株式会社 | モルフォリノオリゴヌクレオチドの製造方法 |
| WO2019216433A1 (ja) | 2018-05-10 | 2019-11-14 | 日本新薬株式会社 | オリゴ核酸化合物の製造方法 |
| WO2021095875A1 (ja) | 2019-11-13 | 2021-05-20 | 日本新薬株式会社 | オリゴ核酸化合物の製造方法 |
| WO2021095874A1 (ja) | 2019-11-13 | 2021-05-20 | 日本新薬株式会社 | オリゴ核酸化合物の製造方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3398378B2 (ja) | 1989-12-20 | 2003-04-21 | アンチビラルス・インコーポレイテツド | リン含有キラルインターサブユニットリンケージを有する非電荷モルホリノ―基体ポリマー |
| MX2010004955A (es) | 2007-11-15 | 2010-06-30 | Avi Biopharma Inc | Metodo de sintesis de oligomeros de morfolina. |
| JP5548852B2 (ja) | 2009-05-29 | 2014-07-16 | 国立大学法人東京農工大学 | 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法 |
| EP2816053B1 (en) | 2012-02-17 | 2021-03-24 | Ajinomoto Co., Inc. | Base-protected oligonucleotide |
| EP2921499B1 (en) | 2012-11-14 | 2020-01-22 | Takeda Pharmaceutical Company Limited | Method for liquid-phase synthesis of nucleic acids |
| JP6673211B2 (ja) | 2014-10-14 | 2020-03-25 | 味の素株式会社 | モルフォリノオリゴヌクレオチドの製造方法 |
| US12012427B2 (en) * | 2019-10-31 | 2024-06-18 | Indian Association For The Cultivation Of Science | Synthesis of Fmoc-protected morpholino monomers and their use in the synthesis of morpholino oligomer |
-
2022
- 2022-04-27 US US18/288,057 patent/US20240254158A1/en active Pending
- 2022-04-27 AU AU2022266379A patent/AU2022266379A1/en active Pending
- 2022-04-27 EP EP22795867.5A patent/EP4332111A4/en active Pending
- 2022-04-27 CA CA3218264A patent/CA3218264A1/en active Pending
- 2022-04-27 WO PCT/JP2022/019139 patent/WO2022230954A1/ja not_active Ceased
- 2022-04-27 KR KR1020237039847A patent/KR20240004559A/ko active Pending
- 2022-04-27 CN CN202280031612.XA patent/CN117279926A/zh active Pending
- 2022-04-27 JP JP2023517605A patent/JP7825613B2/ja active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005028494A1 (ja) | 2003-09-02 | 2005-03-31 | Takeshi Wada | ５'-ホスフィチル化モノマーおよびh-ホスホネートオリゴヌクレオチド誘導体の製造方法 |
| WO2012043730A1 (ja) | 2010-09-30 | 2012-04-05 | 日本新薬株式会社 | モルホリノ核酸誘導体 |
| WO2014189142A1 (ja) | 2013-05-24 | 2014-11-27 | 味の素株式会社 | モルフォリノオリゴヌクレオチドの製造方法 |
| WO2019216433A1 (ja) | 2018-05-10 | 2019-11-14 | 日本新薬株式会社 | オリゴ核酸化合物の製造方法 |
| WO2021095875A1 (ja) | 2019-11-13 | 2021-05-20 | 日本新薬株式会社 | オリゴ核酸化合物の製造方法 |
| WO2021095874A1 (ja) | 2019-11-13 | 2021-05-20 | 日本新薬株式会社 | オリゴ核酸化合物の製造方法 |
Non-Patent Citations (1)
| Title |
|---|
| Tetrahedron Letters，2015年，Vol.56，pp.4565-4568，corrigendum（2018, Vol.59, pp.1974-1975)及びSupplementary Materialを含む。 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA3218264A1 (en) | 2022-11-03 |
| CN117279926A (zh) | 2023-12-22 |
| EP4332111A1 (en) | 2024-03-06 |
| AU2022266379A1 (en) | 2023-11-09 |
| WO2022230954A1 (ja) | 2022-11-03 |
| EP4332111A4 (en) | 2025-04-23 |
| JPWO2022230954A1 (https=) | 2022-11-03 |
| US20240254158A1 (en) | 2024-08-01 |
| KR20240004559A (ko) | 2024-01-11 |
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