JP7815112B2 - ブラシプロドラッグおよびその使用 - Google Patents

ブラシプロドラッグおよびその使用

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Publication number
JP7815112B2
JP7815112B2 JP2022523174A JP2022523174A JP7815112B2 JP 7815112 B2 JP7815112 B2 JP 7815112B2 JP 2022523174 A JP2022523174 A JP 2022523174A JP 2022523174 A JP2022523174 A JP 2022523174A JP 7815112 B2 JP7815112 B2 JP 7815112B2
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Japan
Prior art keywords
substituted
unsubstituted
instance
macromonomer
salt
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JP2022523174A
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English (en)
Japanese (ja)
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JP2022552416A (ja
JP2022552416A5 (https=
JPWO2021076821A5 (https=
Inventor
ジョンソン，エレミヤ，エー．
ジャン，イヴァン
グエン，ハング，ヴァンタイン
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Massachusetts Institute of Technology
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Massachusetts Institute of Technology
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Publication of JPWO2021076821A5 publication Critical patent/JPWO2021076821A5/ja
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/545—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F4/00—Polymerisation catalysts
    • C08F4/42—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors
    • C08F4/72—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors selected from metals not provided for in group C08F4/44
    • C08F4/74—Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors selected from metals not provided for in group C08F4/44 selected from refractory metals
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G61/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G61/02—Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes
    • C08G61/04—Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aliphatic carbon atoms
    • C08G61/06—Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aliphatic carbon atoms prepared by ring-opening of carbocyclic compounds
    • C08G61/08—Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes only aliphatic carbon atoms prepared by ring-opening of carbocyclic compounds of carbocyclic compounds containing one or more carbon-to-carbon double bonds in the ring
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L65/00—Compositions of macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G2261/10—Definition of the polymer structure
    • C08G2261/14—Side-groups
    • C08G2261/142—Side-chains containing oxygen
    • C08G2261/1426—Side-chains containing oxygen containing carboxy groups (COOH) and/or -C(=O)O-moieties
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G2261/10—Definition of the polymer structure
    • C08G2261/14—Side-groups
    • C08G2261/142—Side-chains containing oxygen
    • C08G2261/1428—Side-chains containing oxygen containing acyl groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G2261/10—Definition of the polymer structure
    • C08G2261/14—Side-groups
    • C08G2261/143—Side-chains containing nitrogen
    • C08G2261/1432—Side-chains containing nitrogen containing amide groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G2261/10—Definition of the polymer structure
    • C08G2261/14—Side-groups
    • C08G2261/149—Side-chains having heteroaromatic units
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G2261/30—Monomer units or repeat units incorporating structural elements in the main chain
    • C08G2261/33—Monomer units or repeat units incorporating structural elements in the main chain incorporating non-aromatic structural elements in the main chain
    • C08G2261/332—Monomer units or repeat units incorporating structural elements in the main chain incorporating non-aromatic structural elements in the main chain containing only carbon atoms
    • C08G2261/3324—Monomer units or repeat units incorporating structural elements in the main chain incorporating non-aromatic structural elements in the main chain containing only carbon atoms derived from norbornene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G2261/40—Polymerisation processes
    • C08G2261/41—Organometallic coupling reactions
    • C08G2261/418—Ring opening metathesis polymerisation [ROMP]
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G2261/70—Post-treatment
    • C08G2261/80—Functional group cleavage, e.g. removal of side-chains or protective groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2261/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G2261/90—Applications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polyethers (AREA)
JP2022523174A 2019-10-16 2020-10-15 ブラシプロドラッグおよびその使用 Active JP7815112B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962916036P 2019-10-16 2019-10-16
US62/916,036 2019-10-16
PCT/US2020/055862 WO2021076821A2 (en) 2019-10-16 2020-10-15 Brush prodrugs and uses thereof

Publications (4)

Publication Number Publication Date
JP2022552416A JP2022552416A (ja) 2022-12-15
JP2022552416A5 JP2022552416A5 (https=) 2023-10-24
JPWO2021076821A5 JPWO2021076821A5 (https=) 2023-10-24
JP7815112B2 true JP7815112B2 (ja) 2026-02-17

Family

ID=73455787

Family Applications (1)

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JP2022523174A Active JP7815112B2 (ja) 2019-10-16 2020-10-15 ブラシプロドラッグおよびその使用

Country Status (8)

Country Link
US (1) US12478683B2 (https=)
EP (1) EP4045562A2 (https=)
JP (1) JP7815112B2 (https=)
KR (1) KR20220085791A (https=)
CN (1) CN114829447A (https=)
AU (1) AU2020368453A1 (https=)
CA (1) CA3154334A1 (https=)
WO (1) WO2021076821A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018067702A1 (en) 2016-10-04 2018-04-12 Massachusetts Institute Of Technology Bottlebrush copolymers and uses thereof
JP7187048B2 (ja) 2017-06-30 2022-12-12 マサチューセッツ インスティテュート オブ テクノロジー 分枝多官能性マクロモノマーおよび関連ポリマーならびにそれらの使用
WO2019006425A1 (en) 2017-06-30 2019-01-03 Massachusetts Institute Of Technology IMAGING AGENTS OF BRUSH ARRAY STAR POLYMERS AND USES THEREOF
EP3774986A1 (en) 2018-04-13 2021-02-17 Massachusetts Institute of Technology Brush prodrugs and uses thereof
EP3837266A1 (en) * 2018-08-17 2021-06-23 Massachusetts Institute of Technology Degradable polymers of a cyclic silyl ether and uses thereof
KR20220085791A (ko) 2019-10-16 2022-06-22 메사추세츠 인스티튜트 오브 테크놀로지 브러시 전구약물 및 그의 용도
WO2021141662A1 (en) 2020-01-10 2021-07-15 Massachusetts Institute Of Technology Proteolysis targeting chimeric molecules (protacs) with functional handles and uses thereof
CN117062852A (zh) 2021-02-01 2023-11-14 麻省理工学院 可再加工的组合物
US12084415B2 (en) 2021-12-20 2024-09-10 Massachusetts Institute Of Technology Biomolecule-polymer-pharmaceutical agent conjugates for delivering the pharmaceutical agent

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003513090A (ja) 1999-11-02 2003-04-08 バジリア ファルマスーチカ アーゲー Ｎ置換カルバモイルオキシアルキルアゾリウム誘導体
JP2013516465A (ja) 2010-01-07 2013-05-13 アルカーメス ファーマ アイルランド リミテッド 第四級アンモニウム塩プロドラッグ
WO2014169073A1 (en) 2013-04-09 2014-10-16 Massachusetts Institute Of Technology Drug delivery polymer and uses thereof
JP2015522028A (ja) 2012-06-27 2015-08-03 アルツハイマーズ・インスティテュート・オブ・アメリカ・インコーポレイテッドＡｌｚｈｅｉｍｅｒ’Ｓ Ｉｎｓｔｉｔｕｔｅ Ｏｆ Ａｍｅｒｉｃａ， Ｉｎｃ． 化合物とその治療用途
JP2020526519A (ja) 2017-06-30 2020-08-31 マサチューセッツ インスティテュート オブ テクノロジー 分枝多官能性マクロモノマーおよび関連ポリマーならびにそれらの使用
JP2022549915A (ja) 2019-09-30 2022-11-29 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー ノッティン－免疫刺激剤複合体ならびに関連組成物および方法

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1071685A (en) 1909-04-29 1913-09-02 New Jersey Patent Co Apparatus for producing duplicate sound-records.
US3337598A (en) 1962-03-05 1967-08-22 Dow Chemical Co 2-methyl-2-phenyl-1, 3-dioxa-2-silacyclohept-5-ene
US3256308A (en) 1962-03-05 1966-06-14 Dow Chemical Co 2-methyl-1, 3-dioxa-2-sila-cyclohept-5-ene
DE2263509C2 (de) * 1972-12-27 1981-12-24 Rudolf Dr. 6380 Bad Homburg Kürner Deodorant
JPS56154493A (en) 1980-04-30 1981-11-30 Shionogi & Co Ltd Novel platinum complex
US4510136A (en) 1981-06-24 1985-04-09 E. I. Du Pont De Nemours And Company Fungicidal 1,2,4-triazole derivatives
JPH05112739A (ja) 1991-10-18 1993-05-07 Nippon Oil & Fats Co Ltd 塗料組成物
US5811515A (en) 1995-06-12 1998-09-22 California Institute Of Technology Synthesis of conformationally restricted amino acids, peptides, and peptidomimetics by catalytic ring closing metathesis
AU767185B2 (en) 1998-03-23 2003-11-06 President And Fellows Of Harvard College Synthesis of compounds and libraries of compounds
US7049373B2 (en) 1999-08-06 2006-05-23 Carnegie Mellon University Process for preparation of graft polymers
US6812238B1 (en) 1999-11-02 2004-11-02 Basilea Pharmaceutica Ag N-substituted carbamoyloxyalkyl-azolium derivatives
JP4162491B2 (ja) 2001-01-25 2008-10-08 アメリカ合衆国 ボロン酸化合物製剤
AU2002303164A1 (en) 2001-03-23 2002-10-08 Protarga, Inc. Fatty amine drug conjugates
ES2269761T3 (es) 2001-04-30 2007-04-01 The Regents Of The University Of Michigan Estructuras organometalicas isorreticulares, procedimiento para su formacion, y diseño sistematico del calibre de poros y funcionalidad de los mismos, con aplicacion para el almacenamiento de gases.
FR2824832B1 (fr) 2001-05-16 2005-05-27 Oreal Polymeres hydrosolubles a squelette hydrosoluble et a unites laterales a lcst, leur procede de preparation, compositions aqueuses les contenant, et leur utilisation dans le domaine cosmetique
US7297290B2 (en) 2003-08-08 2007-11-20 The Board Of Regents Of The University And Community College System Of Nevada Nanostructured magnetorheological fluids and gels
US20050214250A1 (en) 2003-11-06 2005-09-29 Harris J M Method of preparing carboxylic acid functionalized polymers
TW200618820A (en) 2004-11-05 2006-06-16 Alza Corp Liposome formulations of boronic acid compounds
KR100754378B1 (ko) 2006-09-04 2007-08-31 삼성에스디아이 주식회사 실란 화합물을 포함하는 유기전해액 및 리튬 전지
CN101679021B (zh) 2007-03-02 2014-04-30 伊利诺伊大学评议会 药物颗粒送递
WO2010047765A2 (en) 2008-10-20 2010-04-29 Massachussetts Institute Of Technology Nanostructures for drug delivery
CN101412792B (zh) 2008-12-01 2010-08-25 南开大学 一种珠状高分子酰化试剂的合成方法
WO2011084849A1 (en) * 2010-01-07 2011-07-14 Alkermes, Inc. Diaryldiazepine prodrugs for the treatment of neurological and psychological disorders
US8765098B2 (en) 2010-03-30 2014-07-01 International Business Machines Corporation Star polymers, methods of preparation thereof, and uses thereof
AU2011255647A1 (en) 2010-05-18 2012-11-15 Cerulean Pharma Inc. Compositions and methods for treatment of autoimmune and other diseases
US20140193342A1 (en) 2011-06-10 2014-07-10 The Regents Of The University Of California Enzyme directed assembly of particle theranostics
WO2013010676A2 (en) 2011-07-20 2013-01-24 Ecole Nationale Superieure De Chimie De Rennes Supported ionic liquid phase catalyst
HK1205156A1 (en) 2012-01-31 2015-12-11 Cerulean Pharma Inc. Cyclodextrin-based polymers for therapeutic delivery
US9045579B2 (en) 2012-03-13 2015-06-02 California Institute Of Technology Periodic nanostructures from self assembled wedge-type block-copolymers
US9382387B2 (en) 2012-03-13 2016-07-05 California Institute Of Technology Rapid self-assembly of block copolymers to photonic crystals
HK1211832A1 (zh) 2012-05-07 2016-10-14 The General Hospital Corporation 用於癌症療法的抗高血壓藥物的新穎配方及用法
US9410186B2 (en) 2012-07-11 2016-08-09 Nubad Llc Methods and compositions related to nucleic acid binding assays
KR20120113694A (ko) 2012-09-28 2012-10-15 한양대학교 산학협력단 생체적합성 매개 고분자와의 화학적 결합을 이용한 분자 영상화 시스템
US9447220B2 (en) 2012-11-19 2016-09-20 Rohm And Haas Electronic Materials Llc Self-assembled structures, method of manufacture thereof and articles comprising the same
CN103819486B (zh) 2014-01-27 2016-08-17 承德医学院 标记血清糖原磷酸化酶浓度水平的光亲和标记探针分子、其制备方法及医药用途
EP3102585B1 (en) 2014-02-03 2021-05-19 Ohio State Innovation Foundation Boronic acid esters and pharmaceutical formulations thereof
US9447129B2 (en) 2014-02-07 2016-09-20 Massachusetts Institute Of Technology Suprametallogels and uses thereof
AU2015247817C1 (en) 2014-04-14 2022-02-10 Arvinas Operations, Inc. Imide-based modulators of proteolysis and associated methods of use
US9822216B2 (en) 2014-07-25 2017-11-21 Wisconsin Alumni Research Foundation Microphase separation of block copolymer bottlebrushes
US10980744B2 (en) 2014-08-08 2021-04-20 The Regents Of The University Of California High density peptide polymers
CN106715437A (zh) 2014-08-08 2017-05-24 达纳-法伯癌症研究所股份有限公司 二氮杂环庚烷衍生物及其用途
US10153513B2 (en) 2015-03-09 2018-12-11 California Institute Of Technology Triblock brush block copolymers
WO2016172386A1 (en) 2015-04-21 2016-10-27 The Regents Of The University Of California Enzyme-responsive nanoparticles
US10201803B2 (en) 2015-06-09 2019-02-12 The Regents Of The University Of California Polymer-metal organic framework materials and methods of using the same
CN106310289B (zh) * 2015-06-24 2020-10-13 天津键凯科技有限公司 一种聚乙二醇和麻醉药的结合物及其制备方法
US20200078468A1 (en) 2016-04-13 2020-03-12 Tarveda Therapeutics, Inc. Neurotensin receptor binding conjugates and formulations thereof
TWI759301B (zh) 2016-05-24 2022-04-01 美商安美基公司 聚乙二醇化卡非佐米化合物
WO2017214337A1 (en) 2016-06-07 2017-12-14 Massachusetts Institute Of Technology Drug delivery polymers and uses thereof
US10793683B2 (en) 2016-07-27 2020-10-06 Massachusetts Institute Of Technology Block co-poly(metal organic nanostructures) (BCPMONs) and uses thereof
WO2018039577A1 (en) 2016-08-26 2018-03-01 Massachusetts Institute Of Technology Bottlebrush polymers and uses thereof
WO2018067702A1 (en) 2016-10-04 2018-04-12 Massachusetts Institute Of Technology Bottlebrush copolymers and uses thereof
WO2018073790A1 (en) 2016-10-20 2018-04-26 Pfizer Inc. Therapeutic particles with peptide boronic acid or boronate ester compounds and methods of making and using same
WO2018106738A1 (en) 2016-12-05 2018-06-14 Massachusetts Institute Of Technology Brush-arm star polymers, conjugates and particles, and uses thereof
US11040958B2 (en) 2017-02-17 2021-06-22 Wuhan Ll Science And Technology Development Co., Ltd. Triazole antimicrobial derivative, pharmaceutical composition and use thereof
CN108727581A (zh) 2017-04-18 2018-11-02 华东师范大学 以苯硼酸酯为连接单元的两亲性喜树碱高分子前药及其制备方法和应用
US10894854B2 (en) 2017-05-01 2021-01-19 Florida State University Research Foundation, Inc. Functional bottlebrush polymers
WO2019006425A1 (en) 2017-06-30 2019-01-03 Massachusetts Institute Of Technology IMAGING AGENTS OF BRUSH ARRAY STAR POLYMERS AND USES THEREOF
US10973847B2 (en) 2017-06-30 2021-04-13 Massachusetts Institute Of Technology Core-to-surface polymerization for the synthesis of star polymers and uses thereof
EP3774986A1 (en) 2018-04-13 2021-02-17 Massachusetts Institute of Technology Brush prodrugs and uses thereof
WO2019201123A1 (zh) 2018-04-20 2019-10-24 四川科伦博泰生物医药股份有限公司 一种多功能化合物、其制备方法及其在医药上的应用
EP3837266A1 (en) 2018-08-17 2021-06-23 Massachusetts Institute of Technology Degradable polymers of a cyclic silyl ether and uses thereof
WO2020160102A1 (en) 2019-01-29 2020-08-06 Colorado State University Research Foundation Group transfer polymerization for the production of functional monomers
AU2020278465B2 (en) 2019-05-20 2026-04-23 Dana-Farber Cancer Institute, Inc. Boronic ester prodrugs and uses thereof
KR20220085791A (ko) 2019-10-16 2022-06-22 메사추세츠 인스티튜트 오브 테크놀로지 브러시 전구약물 및 그의 용도
EP4058501A1 (en) 2019-11-15 2022-09-21 Massachusetts Institute of Technology Functional oligomers and functional polymers including hydroxylated polymers and conjugates thereof and uses thereof
WO2021141662A1 (en) 2020-01-10 2021-07-15 Massachusetts Institute Of Technology Proteolysis targeting chimeric molecules (protacs) with functional handles and uses thereof
US12084415B2 (en) 2021-12-20 2024-09-10 Massachusetts Institute Of Technology Biomolecule-polymer-pharmaceutical agent conjugates for delivering the pharmaceutical agent

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003513090A (ja) 1999-11-02 2003-04-08 バジリア ファルマスーチカ アーゲー Ｎ置換カルバモイルオキシアルキルアゾリウム誘導体
JP2013516465A (ja) 2010-01-07 2013-05-13 アルカーメス ファーマ アイルランド リミテッド 第四級アンモニウム塩プロドラッグ
JP2015522028A (ja) 2012-06-27 2015-08-03 アルツハイマーズ・インスティテュート・オブ・アメリカ・インコーポレイテッドＡｌｚｈｅｉｍｅｒ’Ｓ Ｉｎｓｔｉｔｕｔｅ Ｏｆ Ａｍｅｒｉｃａ， Ｉｎｃ． 化合物とその治療用途
WO2014169073A1 (en) 2013-04-09 2014-10-16 Massachusetts Institute Of Technology Drug delivery polymer and uses thereof
JP2020526519A (ja) 2017-06-30 2020-08-31 マサチューセッツ インスティテュート オブ テクノロジー 分枝多官能性マクロモノマーおよび関連ポリマーならびにそれらの使用
JP2022549915A (ja) 2019-09-30 2022-11-29 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー ノッティン－免疫刺激剤複合体ならびに関連組成物および方法

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