JP7808029B2 - 心血管石灰化の治療、進行の抑制、または予防における使用のためのイノシトールリン酸化合物 - Google Patents

心血管石灰化の治療、進行の抑制、または予防における使用のためのイノシトールリン酸化合物

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Publication number
JP7808029B2
JP7808029B2 JP2022516283A JP2022516283A JP7808029B2 JP 7808029 B2 JP7808029 B2 JP 7808029B2 JP 2022516283 A JP2022516283 A JP 2022516283A JP 2022516283 A JP2022516283 A JP 2022516283A JP 7808029 B2 JP7808029 B2 JP 7808029B2
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Prior art keywords
calcification
pharmaceutical composition
weeks
inositol
subject
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JP2022516283A
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English (en)
Japanese (ja)
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JPWO2021094331A5 (https=
JP2023500020A5 (https=
JP2023500020A (ja
Inventor
ベスタルド，フアン ペレロ
ロカ，カロリーナ サルセド
レイネス，ミゲル・ダビド フェレール
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ビフォー （インターナショナル） リミテッド
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A61K31/6615—Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2022516283A 2019-11-11 2020-11-10 心血管石灰化の治療、進行の抑制、または予防における使用のためのイノシトールリン酸化合物 Active JP7808029B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19382990.0 2019-11-11
EP19382990.0A EP3818983A1 (en) 2019-11-11 2019-11-11 Inositol phosphate compounds for use in treating, inhibiting the progression, or preventing cardiovascular calcification
PCT/EP2020/081674 WO2021094331A1 (en) 2019-11-11 2020-11-10 Inositol phosphate compounds for use in treating, inhibiting the progression, or preventing cardiovascular calcification

Publications (4)

Publication Number Publication Date
JP2023500020A JP2023500020A (ja) 2023-01-04
JPWO2021094331A5 JPWO2021094331A5 (https=) 2023-10-26
JP2023500020A5 JP2023500020A5 (https=) 2023-10-26
JP7808029B2 true JP7808029B2 (ja) 2026-01-28

Family

ID=68610132

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022516283A Active JP7808029B2 (ja) 2019-11-11 2020-11-10 心血管石灰化の治療、進行の抑制、または予防における使用のためのイノシトールリン酸化合物

Country Status (10)

Country Link
US (2) US20220339171A1 (https=)
EP (2) EP3818983A1 (https=)
JP (1) JP7808029B2 (https=)
KR (1) KR20220099957A (https=)
CN (1) CN114585367A (https=)
AU (1) AU2020381775B2 (https=)
CA (1) CA3156023A1 (https=)
IL (1) IL292118B1 (https=)
MX (1) MX2022004971A (https=)
WO (1) WO2021094331A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018445164B2 (en) * 2018-10-11 2025-05-29 Vifor (International) Ltd. Inositol phosphates for the treatment of ectopic calcification
CN113712976B (zh) * 2021-10-21 2023-02-24 中国人民解放军海军军医大学 小分子化合物肌醇六磷酸酯钠水合物在制备抗SARS-CoV-2药物中的应用
WO2024047037A1 (en) 2022-08-30 2024-03-07 ETH Zürich Compositions for parenteral sustained release delivery of hydrophilic drugs
US20250217970A1 (en) * 2023-12-28 2025-07-03 Case Western Reserve University Risk prediction of heart failure

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140271915A1 (en) 2013-03-15 2014-09-18 Laboratoris Sanifit, S.L. Use of derivatives containing c-o-p bonds in patients with kidney failure
JP2016514119A (ja) 2013-03-15 2016-05-19 ラボラトリス サニフィット，エセ．エレ． 腎不全を患っている患者におけるｃ−ｏ−ｐ結合を含む誘導体の使用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5007790A (en) 1989-04-11 1991-04-16 Depomed Systems, Inc. Sustained-release oral drug dosage form
ATE173159T1 (de) 1992-03-25 1998-11-15 Depomed Systems Inc Auf hydroxyethylzellulose basierende oralen arzneidosisformen mit verzoegerter wirkstoffabgabe
US5582837A (en) 1992-03-25 1996-12-10 Depomed, Inc. Alkyl-substituted cellulose-based sustained-release oral drug dosage forms
WO1997047285A1 (en) 1996-06-10 1997-12-18 Depomed, Inc. Gastric-retentive oral controlled drug delivery system with enhanced retention properties
US5972389A (en) 1996-09-19 1999-10-26 Depomed, Inc. Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter
CA2290624C (en) 1997-06-06 2006-12-05 John W. Shell Gastric-retentive oral drug dosage forms for controlled release of highly soluble drugs
US6635280B2 (en) 1997-06-06 2003-10-21 Depomed, Inc. Extending the duration of drug release within the stomach during the fed mode
CA2389236A1 (en) 1999-11-02 2001-05-10 Depomed, Inc. Pharmacological inducement of the fed mode for enhanced drug administration to the stomach
ES2270982T3 (es) 2000-02-04 2007-04-16 Depomed, Inc. Forma de dosificacion de nucleo y carcasa que se aproxima a una liberacion del farmaco de orden cero.
US6488962B1 (en) 2000-06-20 2002-12-03 Depomed, Inc. Tablet shapes to enhance gastric retention of swellable controlled-release oral dosage forms
US6451808B1 (en) 2000-10-17 2002-09-17 Depomed, Inc. Inhibition of emetic effect of metformin with 5-HT3 receptor antagonists
JP2004532259A (ja) 2001-05-29 2004-10-21 デポメッド ディベロップメント リミティド 胃食道逆流症及び夜間に胃酸分泌が回復する現象の治療方法
US6723340B2 (en) 2001-10-25 2004-04-20 Depomed, Inc. Optimal polymer mixtures for gastric retentive tablets
CA2409552A1 (en) 2001-10-25 2003-04-25 Depomed, Inc. Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract
TWI312285B (en) 2001-10-25 2009-07-21 Depomed Inc Methods of treatment using a gastric retained gabapentin dosage
US20030091630A1 (en) 2001-10-25 2003-05-15 Jenny Louie-Helm Formulation of an erodible, gastric retentive oral dosage form using in vitro disintegration test data
JP2005508358A (ja) 2001-10-25 2005-03-31 デポメド・インコーポレイテッド 胃滞留型ロサルタン投与量を用いる治療方法
US6682759B2 (en) 2002-02-01 2004-01-27 Depomed, Inc. Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs
ES2232302B1 (es) 2003-11-07 2006-08-01 Universitat De Les Illes Balears Myo-inositol hexafosfato para uso topico.
ES2288126B2 (es) 2006-06-01 2009-07-06 Universitat De Les Illes Balears Utilizacion de fitato como agente inhibidor de la disolucion de cristales de sales calcicas para la prevencion o tratamiento de la osteoporosis.
ES2332636B1 (es) 2008-08-06 2011-02-10 Universitat De Les Illes Balears Composicion de liquido de dialisis.
CN105949234B (zh) 2011-09-29 2018-07-10 苏黎世联邦理工学院 用于治疗艰难梭菌感染的药物化合物
EP2579036A1 (en) 2011-10-06 2013-04-10 Laboratorios Sanifit, S.L. Method for the direct detection and/or quantification of at least one compound with a molecular weight of at least 200
DK3386994T3 (da) 2015-12-11 2020-01-13 Eth Zuerich 4,6-di-(o-thiophosphat)-inositol-1,2,3,5-tetra-o-sulfat mod c. difficile-infektion
EA037572B1 (ru) 2015-12-11 2021-04-15 Этх Цюрих Производные инозитола для применения в патологической кристаллизации

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140271915A1 (en) 2013-03-15 2014-09-18 Laboratoris Sanifit, S.L. Use of derivatives containing c-o-p bonds in patients with kidney failure
JP2016514119A (ja) 2013-03-15 2016-05-19 ラボラトリス サニフィット，エセ．エレ． 腎不全を患っている患者におけるｃ−ｏ−ｐ結合を含む誘導体の使用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
British Journal of Clinical Pharmacology，2018年，Vol.84，p.2867-2876
Journal of Nephrology，2019年08月10日，Vol.32，p.811-821

Also Published As

Publication number Publication date
US20250295676A1 (en) 2025-09-25
IL292118A (en) 2022-06-01
IL292118B1 (en) 2026-04-01
AU2020381775A1 (en) 2022-04-14
WO2021094331A1 (en) 2021-05-20
EP4058030A1 (en) 2022-09-21
AU2020381775B2 (en) 2026-03-26
KR20220099957A (ko) 2022-07-14
US20220339171A1 (en) 2022-10-27
CA3156023A1 (en) 2021-05-20
CN114585367A (zh) 2022-06-03
EP3818983A1 (en) 2021-05-12
JP2023500020A (ja) 2023-01-04
MX2022004971A (es) 2022-06-08

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