JP7802077B2 - ウラシル化合物の製造方法 - Google Patents
ウラシル化合物の製造方法Info
- Publication number
- JP7802077B2 JP7802077B2 JP2023534782A JP2023534782A JP7802077B2 JP 7802077 B2 JP7802077 B2 JP 7802077B2 JP 2023534782 A JP2023534782 A JP 2023534782A JP 2023534782 A JP2023534782 A JP 2023534782A JP 7802077 B2 JP7802077 B2 JP 7802077B2
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- unsubstituted
- represented
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C07D239/16—Nitrogen atoms not forming part of a nitro radical acylated on said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021115884 | 2021-07-13 | ||
| JP2021115884 | 2021-07-13 | ||
| JP2021131516 | 2021-08-12 | ||
| JP2021131516 | 2021-08-12 | ||
| PCT/JP2022/027185 WO2023286719A1 (ja) | 2021-07-13 | 2022-07-11 | ウラシル化合物の製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2023286719A1 JPWO2023286719A1 (https=) | 2023-01-19 |
| JP7802077B2 true JP7802077B2 (ja) | 2026-01-19 |
Family
ID=84919396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023534782A Active JP7802077B2 (ja) | 2021-07-13 | 2022-07-11 | ウラシル化合物の製造方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20240317692A1 (https=) |
| EP (1) | EP4371978A4 (https=) |
| JP (1) | JP7802077B2 (https=) |
| WO (1) | WO2023286719A1 (https=) |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014533287A (ja) | 2011-11-14 | 2014-12-11 | セファロン、インク． | ＡＸＬおよびｃ−ＭＥＴキナーゼ阻害剤としてのウラシル誘導体 |
| JP2016522263A (ja) | 2013-06-21 | 2016-07-28 | マイオカーディア，インク | 心臓状態に対するピリミジンジオン化合物 |
| JP2017500362A (ja) | 2013-12-26 | 2017-01-05 | イグナイタ インコーポレイテッド | ピラゾロ［１，５−ａ］ピリジン誘導体およびその使用方法 |
| WO2018122559A1 (en) | 2016-12-29 | 2018-07-05 | Redag Crop Protection Ltd | Agricultural chemicals |
| WO2019213340A1 (en) | 2018-05-03 | 2019-11-07 | Bristol-Myers Squibb Company | Uracil derivatives as mer-axl inhibitors |
| JP2020535168A (ja) | 2017-09-27 | 2020-12-03 | インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ | Ｔａｍ阻害剤として有用なピロロトリアジン誘導体の塩 |
| JP2021504367A (ja) | 2017-11-24 | 2021-02-15 | 南京明徳新薬研発有限公司Ｍｅｄｓｈｉｎｅ Ｄｉｓｃｏｖｅｒｙ Ｉｎｃ． | ｃ−ＭＥＴ／ＡＸＬ阻害剤としてのウラシル系化合物 |
| US20210077492A1 (en) | 2019-09-17 | 2021-03-18 | The Trustees Of Indiana University | Methods and compositions of treating pancreatic cancer |
| WO2021085389A1 (ja) | 2019-10-28 | 2021-05-06 | 日本曹達株式会社 | ２，６－ジオキソ－３，６－ジヒドロピリミジン化合物並びに農園芸用殺菌剤、殺線虫剤、および医療用・動物用抗真菌剤 |
| JP2021512055A (ja) | 2018-01-17 | 2021-05-13 | 南京薬捷安康生物科技有限公司 | Ｔａｍファミリーキナーゼ／及びｃｓｆ１ｒキナーゼ阻害剤及びその用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2687415A (en) * | 1952-04-03 | 1954-08-24 | Nepera Chemical Co Inc | 4-substituted-2-chloro-5-benzylpyrimidine compounds |
| WO2006135763A2 (en) * | 2005-06-09 | 2006-12-21 | The Johns Hopkins University | Inhibitors of dna repair enzymes and methods of use thereof |
| JP2021115884A (ja) | 2020-01-22 | 2021-08-10 | 株式会社ジェイテクト | 四輪駆動車 |
| JP7500988B2 (ja) | 2020-02-21 | 2024-06-18 | ヤマハ株式会社 | 鍵盤楽器のソステヌート機構、鍵盤楽器 |
| JPWO2023017699A1 (https=) * | 2021-08-12 | 2023-02-16 |
-
2022
- 2022-07-11 JP JP2023534782A patent/JP7802077B2/ja active Active
- 2022-07-11 EP EP22842063.4A patent/EP4371978A4/en active Pending
- 2022-07-11 WO PCT/JP2022/027185 patent/WO2023286719A1/ja not_active Ceased
- 2022-07-11 US US18/577,779 patent/US20240317692A1/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014533287A (ja) | 2011-11-14 | 2014-12-11 | セファロン、インク． | ＡＸＬおよびｃ−ＭＥＴキナーゼ阻害剤としてのウラシル誘導体 |
| JP2016522263A (ja) | 2013-06-21 | 2016-07-28 | マイオカーディア，インク | 心臓状態に対するピリミジンジオン化合物 |
| JP2017500362A (ja) | 2013-12-26 | 2017-01-05 | イグナイタ インコーポレイテッド | ピラゾロ［１，５−ａ］ピリジン誘導体およびその使用方法 |
| WO2018122559A1 (en) | 2016-12-29 | 2018-07-05 | Redag Crop Protection Ltd | Agricultural chemicals |
| JP2020535168A (ja) | 2017-09-27 | 2020-12-03 | インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ | Ｔａｍ阻害剤として有用なピロロトリアジン誘導体の塩 |
| JP2021504367A (ja) | 2017-11-24 | 2021-02-15 | 南京明徳新薬研発有限公司Ｍｅｄｓｈｉｎｅ Ｄｉｓｃｏｖｅｒｙ Ｉｎｃ． | ｃ−ＭＥＴ／ＡＸＬ阻害剤としてのウラシル系化合物 |
| JP2021512055A (ja) | 2018-01-17 | 2021-05-13 | 南京薬捷安康生物科技有限公司 | Ｔａｍファミリーキナーゼ／及びｃｓｆ１ｒキナーゼ阻害剤及びその用途 |
| WO2019213340A1 (en) | 2018-05-03 | 2019-11-07 | Bristol-Myers Squibb Company | Uracil derivatives as mer-axl inhibitors |
| US20210077492A1 (en) | 2019-09-17 | 2021-03-18 | The Trustees Of Indiana University | Methods and compositions of treating pancreatic cancer |
| WO2021085389A1 (ja) | 2019-10-28 | 2021-05-06 | 日本曹達株式会社 | ２，６－ジオキソ－３，６－ジヒドロピリミジン化合物並びに農園芸用殺菌剤、殺線虫剤、および医療用・動物用抗真菌剤 |
Non-Patent Citations (1)
| Title |
|---|
| Boiteau, JEAN-GUY, et al.，An efficient multi-component synthesis of N-1-alkylated 5-nitrouracils from α-amino acids，Tetrahedron Letters，2016年，Vol.57(22)，p.2367-2371 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2023286719A1 (ja) | 2023-01-19 |
| EP4371978A4 (en) | 2025-09-10 |
| EP4371978A1 (en) | 2024-05-22 |
| JPWO2023286719A1 (https=) | 2023-01-19 |
| US20240317692A1 (en) | 2024-09-26 |
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