JP7797473B2 - 5-ht2a受容体阻害剤又は逆作動薬、その調製方法、及びその用途 - Google Patents
5-ht2a受容体阻害剤又は逆作動薬、その調製方法、及びその用途Info
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- JP7797473B2 JP7797473B2 JP2023504487A JP2023504487A JP7797473B2 JP 7797473 B2 JP7797473 B2 JP 7797473B2 JP 2023504487 A JP2023504487 A JP 2023504487A JP 2023504487 A JP2023504487 A JP 2023504487A JP 7797473 B2 JP7797473 B2 JP 7797473B2
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- branched
- linear
- independently selected
- alkyl
- hydrogen atom
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
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- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
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- C07C275/26—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
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- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
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- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
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- C07C2601/14—The ring being saturated
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025280400A JP2026065019A (ja) | 2020-07-22 | 2025-12-24 | 5-ht2a受容体阻害剤又は逆作動薬、その調製方法、及びその用途 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010708352 | 2020-07-22 | ||
| CN202010708352.8 | 2020-07-22 | ||
| CN202110364023 | 2021-04-03 | ||
| CN202110364023.0 | 2021-04-03 | ||
| PCT/CN2021/107774 WO2022017440A1 (zh) | 2020-07-22 | 2021-07-22 | 5-ht 2a受体抑制剂或反向激动剂及其制备方法和应用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025280400A Division JP2026065019A (ja) | 2020-07-22 | 2025-12-24 | 5-ht2a受容体阻害剤又は逆作動薬、その調製方法、及びその用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023535926A JP2023535926A (ja) | 2023-08-22 |
| JP2023535926A5 JP2023535926A5 (https=) | 2024-07-24 |
| JP7797473B2 true JP7797473B2 (ja) | 2026-01-13 |
Family
ID=79728503
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023504487A Active JP7797473B2 (ja) | 2020-07-22 | 2021-07-22 | 5-ht2a受容体阻害剤又は逆作動薬、その調製方法、及びその用途 |
| JP2025280400A Pending JP2026065019A (ja) | 2020-07-22 | 2025-12-24 | 5-ht2a受容体阻害剤又は逆作動薬、その調製方法、及びその用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025280400A Pending JP2026065019A (ja) | 2020-07-22 | 2025-12-24 | 5-ht2a受容体阻害剤又は逆作動薬、その調製方法、及びその用途 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20230348421A1 (https=) |
| EP (1) | EP4186893A4 (https=) |
| JP (2) | JP7797473B2 (https=) |
| CN (2) | CN114728933B (https=) |
| WO (1) | WO2022017440A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115605202B (zh) | 2020-03-26 | 2025-10-28 | 盐野义制药株式会社 | 具有血清素受体结合活性的芳香族杂环衍生物 |
| US20240083872A1 (en) * | 2020-12-28 | 2024-03-14 | Shionogi & Co., Ltd. | Cyclic amine derivatives having serotonin receptor binding activity |
| AU2023319750A1 (en) * | 2022-08-03 | 2025-02-13 | Luye Innomind Pharma Shijiazhuang Co., Ltd. | 5-ht2a receptor inverse agonist, and preparation method therefor and use thereof |
| CN115850204B (zh) * | 2022-11-26 | 2024-01-19 | 烟台大学 | 四氢苯并噻吩衍生物及其制备方法和应用 |
| WO2025162237A1 (zh) * | 2024-02-02 | 2025-08-07 | 绿叶嘉奥制药石家庄有限公司 | 一种5-ht2a受体反向激动剂的盐型、晶型及其制备方法和应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003516965A (ja) | 1999-12-14 | 2003-05-20 | ソシエテ・ド・コンセイユ・ド・ルシエルシエ・エ・ダアツプリカーション・シヤンテイフイツク・(エス.セー.エール.アー.エス) | 4−アミノピペリジン誘導体及びその医薬としての使用 |
| JP2006516284A (ja) | 2003-01-16 | 2006-06-29 | アカディア ファーマシューティカルズ,インコーポレーテッド | 神経変性疾患用治療薬としての選択的セロトニン2a/2c受容体インバースアゴニスト |
| WO2021193790A1 (ja) | 2020-03-26 | 2021-09-30 | 塩野義製薬株式会社 | セロトニン受容体結合活性を有する芳香族複素環誘導体 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3128280A (en) * | 1959-10-23 | 1964-04-07 | Searle & Co | 1-(alkoxylated/halogenated phenyl)-3-pyridylmethylureas |
| US3829307A (en) * | 1971-04-30 | 1974-08-13 | Stauffer Chemical Co | 1-picolyl-3-phenyl ureas and their utility as herbicides |
| US3991195A (en) * | 1974-05-06 | 1976-11-09 | Stauffer Chemical Company | Method of controlling bacteria |
| DK485176A (da) * | 1975-11-12 | 1977-05-13 | Merck & Co Inc | Fremgangsmade til fremstilling af pyridylurinstoffer |
| RU2002126554A (ru) * | 2000-03-06 | 2004-03-20 | Акадиа Фармасьютикалз, Инк. (Us) | Азациклические соединения для применения при лечении опосредованных серотонином заболеваний |
| CN100509804C (zh) * | 2002-06-24 | 2009-07-08 | 阿卡蒂亚药品公司 | N-取代哌啶衍生物作为血清素受体试剂 |
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| CN116730981B (zh) | 2024-07-02 |
| JP2026065019A (ja) | 2026-04-14 |
| EP4186893A1 (en) | 2023-05-31 |
| JP2023535926A (ja) | 2023-08-22 |
| US20230348421A1 (en) | 2023-11-02 |
| WO2022017440A1 (zh) | 2022-01-27 |
| CN116730981A (zh) | 2023-09-12 |
| EP4186893A4 (en) | 2025-02-05 |
| CN114728933A (zh) | 2022-07-08 |
| CN114728933B (zh) | 2023-06-16 |
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