JP7797473B2 - 5-ht2a受容体阻害剤又は逆作動薬、その調製方法、及びその用途 - Google Patents

5-ht2a受容体阻害剤又は逆作動薬、その調製方法、及びその用途

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JP7797473B2
JP7797473B2 JP2023504487A JP2023504487A JP7797473B2 JP 7797473 B2 JP7797473 B2 JP 7797473B2 JP 2023504487 A JP2023504487 A JP 2023504487A JP 2023504487 A JP2023504487 A JP 2023504487A JP 7797473 B2 JP7797473 B2 JP 7797473B2
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linear
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hydrogen atom
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JP2023535926A (ja
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張睿
葉亮
馬明旭
王文艶
代玉森
田京偉
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嘉奥制薬(石家庄)有限公司
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JP2023504487A 2020-07-22 2021-07-22 5-ht2a受容体阻害剤又は逆作動薬、その調製方法、及びその用途 Active JP7797473B2 (ja)

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CN202010708352 2020-07-22
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PCT/CN2021/107774 WO2022017440A1 (zh) 2020-07-22 2021-07-22 5-ht 2a受体抑制剂或反向激动剂及其制备方法和应用

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CN115605202B (zh) 2020-03-26 2025-10-28 盐野义制药株式会社 具有血清素受体结合活性的芳香族杂环衍生物
US20240083872A1 (en) * 2020-12-28 2024-03-14 Shionogi & Co., Ltd. Cyclic amine derivatives having serotonin receptor binding activity
AU2023319750A1 (en) * 2022-08-03 2025-02-13 Luye Innomind Pharma Shijiazhuang Co., Ltd. 5-ht2a receptor inverse agonist, and preparation method therefor and use thereof
CN115850204B (zh) * 2022-11-26 2024-01-19 烟台大学 四氢苯并噻吩衍生物及其制备方法和应用
WO2025162237A1 (zh) * 2024-02-02 2025-08-07 绿叶嘉奥制药石家庄有限公司 一种5-ht2a受体反向激动剂的盐型、晶型及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003516965A (ja) 1999-12-14 2003-05-20 ソシエテ・ド・コンセイユ・ド・ルシエルシエ・エ・ダアツプリカーション・シヤンテイフイツク・(エス.セー.エール.アー.エス) 4−アミノピペリジン誘導体及びその医薬としての使用
JP2006516284A (ja) 2003-01-16 2006-06-29 アカディア ファーマシューティカルズ,インコーポレーテッド 神経変性疾患用治療薬としての選択的セロトニン2a/2c受容体インバースアゴニスト
WO2021193790A1 (ja) 2020-03-26 2021-09-30 塩野義製薬株式会社 セロトニン受容体結合活性を有する芳香族複素環誘導体

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3128280A (en) * 1959-10-23 1964-04-07 Searle & Co 1-(alkoxylated/halogenated phenyl)-3-pyridylmethylureas
US3829307A (en) * 1971-04-30 1974-08-13 Stauffer Chemical Co 1-picolyl-3-phenyl ureas and their utility as herbicides
US3991195A (en) * 1974-05-06 1976-11-09 Stauffer Chemical Company Method of controlling bacteria
DK485176A (da) * 1975-11-12 1977-05-13 Merck & Co Inc Fremgangsmade til fremstilling af pyridylurinstoffer
RU2002126554A (ru) * 2000-03-06 2004-03-20 Акадиа Фармасьютикалз, Инк. (Us) Азациклические соединения для применения при лечении опосредованных серотонином заболеваний
CN100509804C (zh) * 2002-06-24 2009-07-08 阿卡蒂亚药品公司 N-取代哌啶衍生物作为血清素受体试剂
US20050261278A1 (en) * 2004-05-21 2005-11-24 Weiner David M Selective serotonin receptor inverse agonists as therapeutics for disease
US20120183600A1 (en) * 2007-01-16 2012-07-19 Chien-Hung Chen Novel composition for treating metabolic syndrome and other conditions
WO2008141057A1 (en) * 2007-05-08 2008-11-20 Auspex Pharmaceuticals, Inc. Deuterated pimavanserin 1- (4-flu0r0benzyl) -3- (4-isobutoxybenzyl) -1- ( l-methyl-piperidin-4-yl) -urea
WO2009039461A2 (en) * 2007-09-21 2009-03-26 Acadia Pharmaceuticals, Inc. N-substituted piperidine derivatives as serotonin receptor agents
JP5567483B2 (ja) * 2007-10-09 2014-08-06 ダウ アグロサイエンシィズ エルエルシー 殺虫性置換アジニル誘導体
WO2010111353A1 (en) * 2009-03-25 2010-09-30 Acadia Pharmaceuticals, Inc. N-substituted piperidine derivatives as serotonin receptor agents
WO2010141696A1 (en) * 2009-06-04 2010-12-09 Dara Biosciences, Inc. Methods of treating or preventing psoriasis, and/or alzheimer's disease using indane acetic acid derivatives
WO2014144130A2 (en) * 2013-03-15 2014-09-18 Als Mountain Llc Pharmaceutical composition comprising an ampk activator and a serotonergic agent and methods of use thereof
TWI703130B (zh) * 2014-03-07 2020-09-01 瑞士商赫爾辛保健股份有限公司 對位取代的不對稱脲及其醫療用途
WO2017172757A1 (en) * 2016-03-29 2017-10-05 Acadia Pharmaceuticals Inc. 5-ht2a serotonin receptor inverse agonists or antagonists for use in reducing amyloid-beta peptides and accumulation of amyloid plaques
CN109111385B (zh) * 2017-06-23 2023-06-30 上海翰森生物医药科技有限公司 5-ht2a受体抑制剂及其制备方法和应用
SG11202001062XA (en) * 2017-08-21 2020-03-30 Acadia Pharm Inc Compounds, salts thereof and methods for treatment of diseases
WO2019040106A2 (en) * 2017-08-21 2019-02-28 Acadia Pharmaceuticals Inc. COMPOUNDS, RELATED SALTS AND METHODS FOR THE TREATMENT OF DISEASES
CN113214141B (zh) * 2020-01-21 2022-04-08 瀚远医药有限公司 5ht2a受体拮抗剂及其制备和应用
AU2023319750A1 (en) * 2022-08-03 2025-02-13 Luye Innomind Pharma Shijiazhuang Co., Ltd. 5-ht2a receptor inverse agonist, and preparation method therefor and use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003516965A (ja) 1999-12-14 2003-05-20 ソシエテ・ド・コンセイユ・ド・ルシエルシエ・エ・ダアツプリカーション・シヤンテイフイツク・(エス.セー.エール.アー.エス) 4−アミノピペリジン誘導体及びその医薬としての使用
JP2006516284A (ja) 2003-01-16 2006-06-29 アカディア ファーマシューティカルズ,インコーポレーテッド 神経変性疾患用治療薬としての選択的セロトニン2a/2c受容体インバースアゴニスト
WO2021193790A1 (ja) 2020-03-26 2021-09-30 塩野義製薬株式会社 セロトニン受容体結合活性を有する芳香族複素環誘導体

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Bioorganic & Medicinal Chemistry Letters,2010年,Vol.20(7),p.2359-2364
RN;2320273-97-8, 2307356-42-7, 2306720-81-8, 2108752-69-6,DATABASE REGISTRY [ONLINE],2019年05月29日,Retrieved from STN,検索日:19 MAY 2025

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