JP7792335B2 - 細胞の調節されたアーマリングのための方法及び組成物 - Google Patents

細胞の調節されたアーマリングのための方法及び組成物

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JP7792335B2
JP7792335B2 JP2022535807A JP2022535807A JP7792335B2 JP 7792335 B2 JP7792335 B2 JP 7792335B2 JP 2022535807 A JP2022535807 A JP 2022535807A JP 2022535807 A JP2022535807 A JP 2022535807A JP 7792335 B2 JP7792335 B2 JP 7792335B2
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expression cassette
tumor
promoter
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JPWO2021119539A5 (https=
JP2023506015A5 (https=
JP2023506015A (ja
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アヤラ マルセラ グズマン
ラッセル モリソン ゴードリー
ミシェル エリザベス ハング
ゲイリー リー
ジャック ズ-チャオ リン
ティモシー クワン-タ ル
アセン ボヤノフ ログエフ
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センティ バイオサイエンシズ インコーポレイテッド
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JP2022535807A 2019-12-12 2020-12-11 細胞の調節されたアーマリングのための方法及び組成物 Active JP7792335B2 (ja)

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US201962947427P 2019-12-12 2019-12-12
US62/947,427 2019-12-12
US202063116103P 2020-11-19 2020-11-19
US63/116,103 2020-11-19
PCT/US2020/064688 WO2021119539A1 (en) 2019-12-12 2020-12-11 Method and compositions for regulated armoring of cells

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JP2023506015A JP2023506015A (ja) 2023-02-14
JPWO2021119539A5 JPWO2021119539A5 (https=) 2023-12-19
JP2023506015A5 JP2023506015A5 (https=) 2023-12-19
JP7792335B2 true JP7792335B2 (ja) 2025-12-25

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Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12180296B2 (en) * 2019-01-08 2024-12-31 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Cross species single domain antibodies targeting mesothelin for treating solid tumors
KR20240022575A (ko) * 2021-06-16 2024-02-20 센티 바이오사이언시스, 인코포레이티드 아머링된 키메라 수용체 및 이의 사용 방법
EP4370697A4 (en) * 2021-07-12 2026-02-25 Childrens Hospital Med Ct DIFFERENTIAL EXPRESSION OF CXCR4 ON HEMATOPOIETIC PROGENITOR CELLS COMPARED TO DIRECT ECOTROPISM AND LONG-TERM STEM CELL ENGRAVING
US20240327521A1 (en) * 2021-07-29 2024-10-03 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Synthetic nucleic acid elements for enhancing car t cell efficacy
CA3232972A1 (en) * 2021-10-28 2023-05-04 Steven C. Quay Endoxifen for treatment of cancers
CN118556086A (zh) * 2021-11-09 2024-08-27 美国政府(由卫生和人类服务部的部长所代表) 靶向磷脂酰肌醇蛋白聚糖-3(gpc3)的含有igg4铰链的嵌合抗原受体及其用途
WO2023114910A2 (en) * 2021-12-15 2023-06-22 Senti Biosciences, Inc. Activation responsive promoters and uses thereof
WO2023215724A1 (en) * 2022-05-01 2023-11-09 Factor Bioscience Inc. Methods for reprogramming and gene editing cells
WO2024102943A1 (en) * 2022-11-09 2024-05-16 Senti Biosciences, Inc. Armed chimeric receptors and methods of use thereof
TW202434618A (zh) * 2023-01-09 2024-09-01 美商奧特佩斯生化股份有限公司 經設計之細胞激素組合物及使用方法
AU2024309243A1 (en) 2023-06-27 2026-01-29 Lyell Immunopharma, Inc. Il-12 stability variants
WO2025049866A1 (en) * 2023-08-30 2025-03-06 Senti Biosciences, Inc. Engineered minimal core promoter and uses thereof
WO2025072098A1 (en) * 2023-09-28 2025-04-03 Dna Twopointo Inc. Inducible expression systems
WO2025144762A1 (en) * 2023-12-28 2025-07-03 Immorta Bio, Inc. Reprogrammed cell modulation of cancer microenvironment by tumor homing personalized regenerative cells

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130158098A1 (en) 2010-06-21 2013-06-20 The Board Of Trustees Of The Leland Standford Junior University Alkenyl Substituted Cycloaliphatic Compounds as Chemical Inducers of Proximity
JP2013527753A (ja) 2010-03-23 2013-07-04 イントレキソン コーポレーション 治療タンパク質を条件的に発現するベクター、該ベクターを含む宿主細胞およびそれらの使用
CN103772506A (zh) 2012-10-22 2014-05-07 北京唯尚立德生物科技有限公司 一种“转录激活子样效应因子-功能基团-雌激素受体”功能蛋白及其应用
WO2018111763A1 (en) 2016-12-12 2018-06-21 Seattle Children's Hospital (dba Seattle Children's Research Institute) Chimeric transcription factor variants with augmented sensitivity to drug ligand induction of transgene expression in mammalian cells
US20180179509A1 (en) 2015-06-29 2018-06-28 The Board Of Trustees Of The Leland Stanford Junior University Degron fusion constructs and methods for controlling protein production
JP2022532236A (ja) 2019-05-16 2022-07-13 トラスティーズ オブ ボストン ユニバーシティ 調節された合成遺伝子発現システム

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2479254A1 (en) * 2005-08-24 2012-07-25 The Scripps Research Institute Translation enhancer-element dependent vector systems
SG11201407972RA (en) * 2012-06-01 2015-01-29 Us Health High-affinity monoclonal antibodies to glypican-3 and use thereof
MX2017012939A (es) * 2015-04-08 2018-05-22 Novartis Ag Terapias cd20, terapias cd22 y terapias de combinacion con una celula que expresa un receptor quimerico de antigeno (car) de cd19.
US10266844B2 (en) * 2015-07-31 2019-04-23 California Institute Of Technology Activity-dependent expression of nucleic acids
JP7500195B2 (ja) * 2016-08-23 2024-06-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア タンパク質分解により切断可能なキメラポリペプチド及びそれらの使用方法
KR20190102259A (ko) * 2017-01-10 2019-09-03 인트렉손 코포레이션 신규의 유전자 스위치 발현 시스템을 통한 폴리펩티드의 발현 조절
CN111683962B (zh) * 2017-11-10 2025-05-16 美国政府(由卫生和人类服务部的部长所代表) 靶向肿瘤抗原的嵌合抗原受体
IL275462B2 (en) * 2017-12-22 2026-01-01 Genentech Inc Targeted integration of nucleic acids

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013527753A (ja) 2010-03-23 2013-07-04 イントレキソン コーポレーション 治療タンパク質を条件的に発現するベクター、該ベクターを含む宿主細胞およびそれらの使用
US20130158098A1 (en) 2010-06-21 2013-06-20 The Board Of Trustees Of The Leland Standford Junior University Alkenyl Substituted Cycloaliphatic Compounds as Chemical Inducers of Proximity
CN103772506A (zh) 2012-10-22 2014-05-07 北京唯尚立德生物科技有限公司 一种“转录激活子样效应因子-功能基团-雌激素受体”功能蛋白及其应用
US20180179509A1 (en) 2015-06-29 2018-06-28 The Board Of Trustees Of The Leland Stanford Junior University Degron fusion constructs and methods for controlling protein production
WO2018111763A1 (en) 2016-12-12 2018-06-21 Seattle Children's Hospital (dba Seattle Children's Research Institute) Chimeric transcription factor variants with augmented sensitivity to drug ligand induction of transgene expression in mammalian cells
JP2022532236A (ja) 2019-05-16 2022-07-13 トラスティーズ オブ ボストン ユニバーシティ 調節された合成遺伝子発現システム

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Conor L. JACOBS et al.,Nature Methods,2018年,Vol. 15, No. 7,pp. 523-526 (pp. 1-20)
Elliot P. TAGUE et al.,Nature Methods,2018年,Vol. 15, No. 7,pp. 519-522 (pp. 1-15)

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