IL293570A - Method and compositions for regulated cell armoring - Google Patents

Method and compositions for regulated cell armoring

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Publication number
IL293570A
IL293570A IL293570A IL29357022A IL293570A IL 293570 A IL293570 A IL 293570A IL 293570 A IL293570 A IL 293570A IL 29357022 A IL29357022 A IL 29357022A IL 293570 A IL293570 A IL 293570A
Authority
IL
Israel
Prior art keywords
domain
optionally
expression cassette
acp
cell
Prior art date
Application number
IL293570A
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English (en)
Hebrew (he)
Original Assignee
Senti Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senti Biosciences Inc filed Critical Senti Biosciences Inc
Publication of IL293570A publication Critical patent/IL293570A/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • A61K35/14—Blood; Artificial blood
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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IL293570A 2019-12-12 2020-12-11 Method and compositions for regulated cell armoring IL293570A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962947427P 2019-12-12 2019-12-12
US202063116103P 2020-11-19 2020-11-19
PCT/US2020/064688 WO2021119539A1 (en) 2019-12-12 2020-12-11 Method and compositions for regulated armoring of cells

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IL293570A true IL293570A (en) 2022-08-01

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IL293570A IL293570A (en) 2019-12-12 2020-12-11 Method and compositions for regulated cell armoring

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US (1) US20230011052A1 (https=)
EP (1) EP4072596A4 (https=)
JP (1) JP7792335B2 (https=)
KR (1) KR20220115602A (https=)
CN (1) CN115087466A (https=)
AU (1) AU2020399805A1 (https=)
CA (1) CA3160614A1 (https=)
IL (1) IL293570A (https=)
TW (1) TW202136507A (https=)
WO (1) WO2021119539A1 (https=)

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US12180296B2 (en) * 2019-01-08 2024-12-31 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Cross species single domain antibodies targeting mesothelin for treating solid tumors
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