CN115087466A - 用于细胞的调控装甲的方法和组合物 - Google Patents

用于细胞的调控装甲的方法和组合物 Download PDF

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CN115087466A
CN115087466A CN202080096411.9A CN202080096411A CN115087466A CN 115087466 A CN115087466 A CN 115087466A CN 202080096411 A CN202080096411 A CN 202080096411A CN 115087466 A CN115087466 A CN 115087466A
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optionally
cells
expression cassette
acp
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M·古兹曼·阿亚拉
R·M·戈德莱
M·E·鸿
G·李
J·T-C·林
T·K-T·卢
A·B·罗格弗
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Senti Biosciences Inc
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Senti Biosciences Inc
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CN202080096411.9A 2019-12-12 2020-12-11 用于细胞的调控装甲的方法和组合物 Pending CN115087466A (zh)

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Application Number Priority Date Filing Date Title
US201962947427P 2019-12-12 2019-12-12
US62/947,427 2019-12-12
US202063116103P 2020-11-19 2020-11-19
US63/116,103 2020-11-19
PCT/US2020/064688 WO2021119539A1 (en) 2019-12-12 2020-12-11 Method and compositions for regulated armoring of cells

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Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12180296B2 (en) * 2019-01-08 2024-12-31 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Cross species single domain antibodies targeting mesothelin for treating solid tumors
KR20240022575A (ko) * 2021-06-16 2024-02-20 센티 바이오사이언시스, 인코포레이티드 아머링된 키메라 수용체 및 이의 사용 방법
EP4370697A4 (en) * 2021-07-12 2026-02-25 Childrens Hospital Med Ct DIFFERENTIAL EXPRESSION OF CXCR4 ON HEMATOPOIETIC PROGENITOR CELLS COMPARED TO DIRECT ECOTROPISM AND LONG-TERM STEM CELL ENGRAVING
US20240327521A1 (en) * 2021-07-29 2024-10-03 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Synthetic nucleic acid elements for enhancing car t cell efficacy
CA3232972A1 (en) * 2021-10-28 2023-05-04 Steven C. Quay Endoxifen for treatment of cancers
CN118556086A (zh) * 2021-11-09 2024-08-27 美国政府(由卫生和人类服务部的部长所代表) 靶向磷脂酰肌醇蛋白聚糖-3（gpc3）的含有igg4铰链的嵌合抗原受体及其用途
WO2023114910A2 (en) * 2021-12-15 2023-06-22 Senti Biosciences, Inc. Activation responsive promoters and uses thereof
WO2023215724A1 (en) * 2022-05-01 2023-11-09 Factor Bioscience Inc. Methods for reprogramming and gene editing cells
WO2024102943A1 (en) * 2022-11-09 2024-05-16 Senti Biosciences, Inc. Armed chimeric receptors and methods of use thereof
TW202434618A (zh) * 2023-01-09 2024-09-01 美商奧特佩斯生化股份有限公司 經設計之細胞激素組合物及使用方法
AU2024309243A1 (en) 2023-06-27 2026-01-29 Lyell Immunopharma, Inc. Il-12 stability variants
WO2025049866A1 (en) * 2023-08-30 2025-03-06 Senti Biosciences, Inc. Engineered minimal core promoter and uses thereof
WO2025072098A1 (en) * 2023-09-28 2025-04-03 Dna Twopointo Inc. Inducible expression systems
WO2025144762A1 (en) * 2023-12-28 2025-07-03 Immorta Bio, Inc. Reprogrammed cell modulation of cancer microenvironment by tumor homing personalized regenerative cells

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103038343A (zh) * 2010-03-23 2013-04-10 英特瑞克斯顿股份有限公司 条件表达治疗蛋白的载体，包含所述载体的宿主细胞，及其应用
CN104520331A (zh) * 2012-06-01 2015-04-15 美国政府(由卫生和人类服务部的部长所代表) 磷脂酰肌醇蛋白聚糖3的高亲和力单克隆抗体及其用途
CN108350058A (zh) * 2015-04-08 2018-07-31 诺华股份有限公司 Cd20疗法、cd22疗法和与cd19嵌合抗原受体(car)表达细胞的联合疗法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2479254A1 (en) * 2005-08-24 2012-07-25 The Scripps Research Institute Translation enhancer-element dependent vector systems
US20130158098A1 (en) 2010-06-21 2013-06-20 The Board Of Trustees Of The Leland Standford Junior University Alkenyl Substituted Cycloaliphatic Compounds as Chemical Inducers of Proximity
CN103772506A (zh) 2012-10-22 2014-05-07 北京唯尚立德生物科技有限公司 一种“转录激活子样效应因子-功能基团-雌激素受体”功能蛋白及其应用
US10550379B2 (en) 2015-06-29 2020-02-04 The Board Of Trustees Of The Leland Stanford Junior University Degron fusion constructs and methods for controlling protein production
US10266844B2 (en) * 2015-07-31 2019-04-23 California Institute Of Technology Activity-dependent expression of nucleic acids
JP7500195B2 (ja) * 2016-08-23 2024-06-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア タンパク質分解により切断可能なキメラポリペプチド及びそれらの使用方法
CN110291200B (zh) 2016-12-12 2024-05-14 西雅图儿童医院（Dba西雅图儿童研究所） 对哺乳动物细胞中转基因表达的药剂配体诱导具有增大的灵敏度的嵌合转录因子变异体
KR20190102259A (ko) * 2017-01-10 2019-09-03 인트렉손 코포레이션 신규의 유전자 스위치 발현 시스템을 통한 폴리펩티드의 발현 조절
CN111683962B (zh) * 2017-11-10 2025-05-16 美国政府(由卫生和人类服务部的部长所代表) 靶向肿瘤抗原的嵌合抗原受体
IL275462B2 (en) * 2017-12-22 2026-01-01 Genentech Inc Targeted integration of nucleic acids
CA3138576A1 (en) 2019-05-16 2020-11-19 Trustees Of Boston University Regulated synthetic gene expression systems

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103038343A (zh) * 2010-03-23 2013-04-10 英特瑞克斯顿股份有限公司 条件表达治疗蛋白的载体，包含所述载体的宿主细胞，及其应用
CN104520331A (zh) * 2012-06-01 2015-04-15 美国政府(由卫生和人类服务部的部长所代表) 磷脂酰肌醇蛋白聚糖3的高亲和力单克隆抗体及其用途
CN108350058A (zh) * 2015-04-08 2018-07-31 诺华股份有限公司 Cd20疗法、cd22疗法和与cd19嵌合抗原受体(car)表达细胞的联合疗法

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