CA3160614A1 - Method and compositions for regulated armoring of cells - Google Patents

Method and compositions for regulated armoring of cells Download PDF

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Publication number
CA3160614A1
CA3160614A1 CA3160614A CA3160614A CA3160614A1 CA 3160614 A1 CA3160614 A1 CA 3160614A1 CA 3160614 A CA3160614 A CA 3160614A CA 3160614 A CA3160614 A CA 3160614A CA 3160614 A1 CA3160614 A1 CA 3160614A1
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domain
optionally
cell
expression cassette
acp
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CA3160614A
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English (en)
French (fr)
Inventor
Marcela GUZMAN AYALA
Russell Morrison GORDLEY
Michelle Elizabeth Hung
Gary Lee
Jack Tzu-Chiao LIN
Timothy Kuan-Ta Lu
Assen Boyanov ROGUEV
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Senti Biosciences Inc
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Senti Biosciences Inc
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Publication of CA3160614A1 publication Critical patent/CA3160614A1/en
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
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    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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CA3160614A 2019-12-12 2020-12-11 Method and compositions for regulated armoring of cells Pending CA3160614A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962947427P 2019-12-12 2019-12-12
US62/947,427 2019-12-12
US202063116103P 2020-11-19 2020-11-19
US63/116,103 2020-11-19
PCT/US2020/064688 WO2021119539A1 (en) 2019-12-12 2020-12-11 Method and compositions for regulated armoring of cells

Publications (1)

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CA3160614A1 true CA3160614A1 (en) 2021-06-17

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CA3160614A Pending CA3160614A1 (en) 2019-12-12 2020-12-11 Method and compositions for regulated armoring of cells

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US (1) US20230011052A1 (https=)
EP (1) EP4072596A4 (https=)
JP (1) JP7792335B2 (https=)
KR (1) KR20220115602A (https=)
CN (1) CN115087466A (https=)
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CA (1) CA3160614A1 (https=)
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