JP7785284B2 - Ｃｄ３８抗体とｉｃａｍ１抗体およびそれらの使用 - Google Patents

Ｃｄ３８抗体とｉｃａｍ１抗体およびそれらの使用

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Publication number
JP7785284B2
JP7785284B2 JP2021526459A JP2021526459A JP7785284B2 JP 7785284 B2 JP7785284 B2 JP 7785284B2 JP 2021526459 A JP2021526459 A JP 2021526459A JP 2021526459 A JP2021526459 A JP 2021526459A JP 7785284 B2 JP7785284 B2 JP 7785284B2
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seq
present
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sequence
nos
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JP2021526459A
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English (en)
Japanese (ja)
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JP2022507485A (ja
JP2022507485A5 (https=
JPWO2020102777A5 (https=
Inventor
リウ，ビン
チェン，シアオチョン
ビッドリングメイヤー，スコット
ポスト，レナード
スゥ，ヤン
イ，ナムギョン
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University of California San Diego UCSD
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University of California San Diego UCSD
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Publication of JP2022507485A publication Critical patent/JP2022507485A/ja
Publication of JP2022507485A5 publication Critical patent/JP2022507485A5/ja
Publication of JPWO2020102777A5 publication Critical patent/JPWO2020102777A5/ja
Priority to JP2025203085A priority Critical patent/JP2026053336A/ja
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2021526459A 2018-11-16 2019-11-15 Ｃｄ３８抗体とｉｃａｍ１抗体およびそれらの使用 Active JP7785284B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025203085A JP2026053336A (ja) 2018-11-16 2025-11-25 Ｃｄ３８抗体とｉｃａｍ１抗体およびそれらの使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862768566P 2018-11-16 2018-11-16
US62/768,566 2018-11-16
PCT/US2019/061884 WO2020102777A1 (en) 2018-11-16 2019-11-15 Cd38 and icam1 antibodies and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025203085A Division JP2026053336A (ja) 2018-11-16 2025-11-25 Ｃｄ３８抗体とｉｃａｍ１抗体およびそれらの使用

Publications (4)

Publication Number Publication Date
JP2022507485A JP2022507485A (ja) 2022-01-18
JP2022507485A5 JP2022507485A5 (https=) 2022-11-22
JPWO2020102777A5 JPWO2020102777A5 (https=) 2022-11-22
JP7785284B2 true JP7785284B2 (ja) 2025-12-15

Family

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Family Applications (2)

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JP2021526459A Active JP7785284B2 (ja) 2018-11-16 2019-11-15 Ｃｄ３８抗体とｉｃａｍ１抗体およびそれらの使用
JP2025203085A Pending JP2026053336A (ja) 2018-11-16 2025-11-25 Ｃｄ３８抗体とｉｃａｍ１抗体およびそれらの使用

Family Applications After (1)

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JP2025203085A Pending JP2026053336A (ja) 2018-11-16 2025-11-25 Ｃｄ３８抗体とｉｃａｍ１抗体およびそれらの使用

Country Status (5)

Country Link
US (1) US12583932B2 (https=)
EP (1) EP3883967A4 (https=)
JP (2) JP7785284B2 (https=)
CN (2) CN120399084A (https=)
WO (1) WO2020102777A1 (https=)

Families Citing this family (12)

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US12583932B2 (en) 2018-11-16 2026-03-24 Virtuoso Binco, Inc. CD38 and ICAM1 antibodies and uses thereof
US20220411508A1 (en) * 2019-09-09 2022-12-29 The Regents Of The University Of California Compositions and methods for making and using multispecific antibodies
JP2023526605A (ja) * 2020-05-14 2023-06-22 ヴィルトゥオーソ ビンコ，インク． ヒト化ｃｄ３８およびｉｃａｍ１抗体、ならびにそれらの使用
WO2023034416A2 (en) * 2021-09-01 2023-03-09 Virtuoso Binco, Inc. Anti-icam1 antibodies and uses thereof
WO2023055376A1 (en) * 2021-09-30 2023-04-06 Virtuoso Binco, Inc. Multispecific antibodies for targeting cd47 and icam1 and methods of use thereof
KR102711074B1 (ko) * 2021-10-26 2024-10-04 재단법인 아산사회복지재단 암 생존자 유래 항체 및 이의 용도
WO2024207177A1 (en) * 2023-04-04 2024-10-10 Genequantum Healthcare (Suzhou) Co., Ltd. Antibody, linkers, payload, conjugates and applications thereof
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof
US20250288611A1 (en) * 2024-03-04 2025-09-18 AffyImmune Therapeutics Inc. Icam-1 targeted car constructs and methods of treatment
CN118440185B (zh) * 2024-05-22 2024-11-19 宁夏大学 抗bhv-1的重组兔单克隆抗体及双抗体夹心elisa试剂和应用
WO2026038869A1 (ko) * 2024-08-12 2026-02-19 재단법인 아산사회복지재단 암 생존자 유래의 당쇄 특이적 항암 항체
CN119529093B (zh) * 2024-11-29 2026-03-06 武汉爱博泰克生物科技有限公司 一种抗人cd68单克隆抗体及其制备方法和应用

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Also Published As

Publication number Publication date
CN113302207A (zh) 2021-08-24
US20220002432A1 (en) 2022-01-06
WO2020102777A1 (en) 2020-05-22
JP2022507485A (ja) 2022-01-18
JP2026053336A (ja) 2026-03-25
CN113302207B (zh) 2025-05-13
EP3883967A4 (en) 2023-04-19
CN120399084A (zh) 2025-08-01
EP3883967A1 (en) 2021-09-29
US12583932B2 (en) 2026-03-24

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